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Anti-aging

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https://www.readbyqxmd.com/read/28538817/in-vitro-and-cellular-activities-of-the-selected-fruits-residues-for-skin-aging-treatment
#1
Nattaya Lourith, Mayuree Kanlayavattanakul, Puxvadee Chaikul, Chaisak Chansriniyom, Pichaporn Bunwatcharaphansakun
Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2 •- scavenging (IC50 = 27.44 ± 0.09) than those of litchi and rambutan (IC50 = 29.57 ± 0.30 and 39.49 ± 0.52 μg/ml, respectively) and the quercetin standard (IC50 = 31.88 ± 0.15 μg/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88...
May 22, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28527408/subcellular-localization-based-comparative-study-on-radioresistant-bacteria-a-novel-approach-to-mine-proteins-involve-in-radioresistance
#2
Divya Vishambra, Malay Srivastava, Kamal Dev, Varun Jaiswal
Radioresistant bacteria (RRB) are among the most radioresistant organisms and has a unique role in evolution. Along with the evolutionary role, radioresistant organisms play important role in paper industries, bioremediation, vaccine development and possibility in anti-aging and anti-cancer treatment. The study of radiation resistance in RRB was mainly focused on cytosolic mechanisms such as DNA repair mechanism, cell cleansing activity and high antioxidant activity. Although it was known that protein localized on outer areas of cell play role in resistance towards extreme condition but the mechanisms/proteins localized on the outer area of cells are not studied for radioresistance...
May 10, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#3
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
May 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28524092/marine-fish-proteins-and-peptides-for-cosmeceuticals-a-review
#4
REVIEW
Jayachandran Venkatesan, Sukumaran Anil, Se-Kwon Kim, Min Suk Shim
Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industries due to their broad spectrum of bioactivities, including antioxidant, antimicrobial, and anti-aging activities. Recently, the development of cosmeceuticals using marine fish-derived proteins and peptides obtained from chemical or enzymatical hydrolysis of fish processing by-products has increased rapidly owing to their activities in antioxidation and tissue regeneration...
May 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28518407/nad-a-big-player-in-cardiac-and-skeletal-muscle-remodeling-and-aging
#5
REVIEW
Pankaj Chaturvedi, Suresh C Tyagi
In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and antiaging molecule. A paper in science by Zhang et al (2016) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al (2002) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al (2002) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure...
May 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28515343/kidney-heart-and-brain-three-organs-targeted-by-ageing-and-glycation
#6
REVIEW
Marie Frimat, Maité Daroux, Rachel Litke, Rémi Nevière, Frédéric J Tessier, Eric Boulanger
Advanced glycation end-product (AGE) is the generic term for a heterogeneous group of derivatives arising from a non-enzymatic reaction between reducing sugars and proteins. In recent years, evidence has accumulated that incriminates AGEs in pathogenic processes associated with both chronic hyperglycaemia and age-related diseases. Regardless of their exogenous or endogenous origin, the accumulation of AGEs and their derivatives could promote accelerated ageing by leading to protein modifications and activating several inflammatory signalling pathways via AGE-specific receptors...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28515006/two-dimensional-multi-heart-cutting-centrifugal-partition-chromatography-liquid-chromatography-for-the-preparative-isolation-of-antioxidants-from-edelweiss-plant
#7
Léa Marlot, Magali Batteau, Marie-Claire Escofet, Sylvie Nuccio, Véronique Coquoin, René De Vaumas, Karine Faure
The Edelweiss plant has been recognized as a very valuable source of anti-aging principles due to its composition of antioxidants compounds: leontopodic acid A and 3,5-dicaffeoylquinic acid. In this work, off-line multi-heart cutting CPC-LC separation was set up at industrial scale in order to isolate and produce new high quality reference material of these two antioxidants from Edelweiss. For this purpose, CPC and HPLC methods were developed and optimized at laboratory scale and a comprehensive CPCxHPLC analysis of the crude extract was established...
April 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28509378/evaluation-of-the-skin-phototoxicity-and-photosensitivity-of-honeybee-venom
#8
Sang Mi Han, In Phyo Hong, Soon Ok Woo, Se Gun Kim, He Rye Jang, Kwan Kyu Park
OBJECTIVE: Bee (Apis mellifera L.) venom (BV) has been used as a cosmetic ingredient owing to its anti-aging, anti-inflammatory, and antibacterial effects. The aim of this study was to assess the skin safety of BV. METHODS: For this purpose, skin phototoxicity and sensitization tests were conducted in healthy male Hartley guinea pigs. The animals were divided into three groups (n=5) for the phototoxicity test: G1 (negative control), G2 (BV gel treatment), and G3 (positive control)...
May 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28506900/chinese-materia-medica-used-in-medicinal-diets
#9
Fang Tan, Yalin Chen, Xiaolei Tan, Yunyun Ma, Yong Peng
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal diets have a history of more than 2000 years. Locally referred to as yaoshan (Chinese: ), a medicinal diet is understood in China as a dietary product that combines herbs and food with the purpose of preventing and treating diseases or improving health under the guidance of traditional Chinese medicine theory. Medicinal diets are used in Chinese people's daily life and in specialized restaurants. Hundreds of Chinese materia medica (CMM) are used in medicinal diets; however, a comprehensive evaluation of medicinal diets is lacking...
May 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28506610/decreased-serum-sirtuin-1-in-chronic-obstructive-pulmonary-disease
#10
Satoru Yanagisawa, Andriana I Papaioannou, Anastasia Papaporfyriou, Jonathan Baker, Chaitanya Vuppusetty, Stelios Loukides, Peter J Barnes, Kazuhiro Ito
BACKGROUND: The protein deacetylase sirtuin-1 (SIRT1) is an anti-aging molecule that is decreased in the lung from patients with chronic obstructive pulmonary disease (COPD). Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 levels have not yet been reported in patients with COPD. METHODS: Serum SIRT1 was measured by Western blotting, and relative ratio of band density in samples against that of a positive control were calculated. RESULTS: Several molecular sizes of SIRT1, including 120kDa (actual size) and fragments (102, 75kDa) were quantified by Western blotting...
May 12, 2017: Chest
https://www.readbyqxmd.com/read/28503972/molecular-mechanisms-of-anti-oxidant-and-anti-aging-effects-induced-by-convallatoxin-in-caenorhabditis-elegans
#11
Jia Xu, Youming Guo, Tianzhuo Sui, Qifei Wang, Yue Zhang, Ruining Zhang, Mingyang Wang, Shuwen Guan, Liping Wang
Convallatoxin is widely used as a cardiac glycoside in acute and chronic congestive heart-failure and paroxysmal tachycardia, with many effects and underlying protective mechanisms on inflammation and cellular proliferation. However, convallatoxin has not been investigated in its antioxidant effects and lifespan extension in Caenorhabditis elegans. In this study, we found that convallatoxin (20 μM) could significantly prolong the lifespan of wild-type C. elegans up to 16.3% through daf-16, but not sir-2.1 signaling and increased thermotolerance and resistance to paraquat-induced oxidative stress...
May 14, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28498360/meristem-plant-cells-as-a-sustainable-source-of-redox-actives-for-skin-rejuvenation
#12
REVIEW
Liudmila G Korkina, Wolfgang Mayer, Chiara de Luca
Recently, aggressive advertisement claimed a "magic role" for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc.), a protective/adaptive response initiates the biosynthesis of secondary metabolites...
May 12, 2017: Biomolecules
https://www.readbyqxmd.com/read/28492484/the-potential-of-triterpenoids-from-loquat-leaves-eriobotrya-japonica-for-prevention-and-treatment-of-skin-disorder
#13
Hui Tan, Tamrakar Sonam, Kuniyoshi Shimizu
The leaves of loquat (Eriobotrya japonica) possess high medicinal value and have been used as traditional medicines. However, there are no evidence-based studies on the skin-care effects of E. japonica leaves. To explore new biological activities of E. japonica leaves against skin disorder and to gain a better understanding of the chemical components associated with bioactivities, we evaluated 18 triterpenoids from E. japonica leaves on anti-melanogenesis, anti-acne, anti-allergy and anti-aging activities. Our results revealed that eight compounds showed anti-melanogenesis activity, of which ursolic acid (1) and maslinic acid (7) were the most potent with the similar selective index to that of arbutin...
May 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28484937/effects-of-ganoderma-lucidum-shell-broken-spore-on-oxidative-stress-of-the-rabbit-urinary-bladder-using-an-in-vivo-model-of-ischemia-reperfusion
#14
Robert M Levin, Li Xia, Wu Wei, Catherine Schuler, Robert E Leggett, Alpha D-Y Lin
Oxidative stress plays an important role in specific disease pathophysiology and the aging process. In the history of human kind, many herbs were utilized for disease prevention and anti-aging treatment. However, there are few direct evidences provided by modern laboratory technology. The current study was designed to evaluate Ganoderma Lucidum's (GL) ability to reduce the damage from in vivo ischemia/reperfusion (I/R) using a rabbit model of I/R that has been effectively utilized to prove the effects of drugs and supplements to reduce oxidative stress...
May 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28484906/the-ethics-of-anti-aging-clinical-trials
#15
Parker Crutchfield
Interventions aiming to slow, stop, or reverse the aging process are starting to enter clinical trials. Though this line of research is nascent, it has the potential to not only prevent prolonged human suffering, but also to extend human well-being. As this line of research develops, it is important to understand the ethical constraints of conducting such research. This paper discusses some of these constraints. In particular, it discusses the ethical difficulties of conducting this research in a way that would produce reliable data regarding the effectiveness of an anti-aging intervention...
May 8, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28477727/gh-and-ageing-pitfalls-and-new-insights
#16
REVIEW
Andrzej Bartke, Justin Darcy
The interrelationships of growth hormone (GH) actions and aging are complex and incompletely understood. The very pronounced age-related decline in GH secretion together with benefits of GH therapy in individuals with congenital or adult GH deficiency (GHD) prompted interest in GH as an anti-aging agent. However, the benefits of treatment of normal elderly subjects with GH appear to be marginal and counterbalanced by worrisome side effects. In laboratory mice, genetic GH deficiency or resistance leads to a remarkable extension of longevity accompanied by signs of delayed and/or slower aging...
February 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28475885/proteostatic-and-metabolic-control-of-stemness
#17
REVIEW
Laura García-Prat, Pedro Sousa-Victor, Pura Muñoz-Cánoves
Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting profoundly different regulatory mechanisms within distinct stem cell types. In recent years, evidence linking metabolism, mitochondrial dynamics, and protein homeostasis (proteostasis) as fundamental regulators of stem cell function has emerged. Here, we discuss new insights into how these networks control potency, self-renewal, differentiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and muscle stem cells and implications for anti-aging research...
May 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28475881/eyeing-the-fountain-of-youth
#18
Magali Saint-Geniez, Mariana Aparecida B Rosales
Stem cell-based disease modeling is an emerging technology for the mechanistic study and therapeutic screening of complex ocular pathologies. In this issue of Cell Stem Cell, Saini et al. (2017) show that iPSC-derived RPE cells from age-related macular degeneration patients express increased levels of pro-inflammatory factors that can be normalized by the anti-aging drug nicotinamide.
May 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28474484/hyaluronan-keeps-mesenchymal-stem-cells-quiescent-and-maintains-the-differentiation-potential-over-time
#19
Tzyy Yue Wong, Chiung-Hsin Chang, Chen-Hsiang Yu, Lynn L H Huang
Hyaluronan (HA), an abundant polysaccharide found in human bodies, plays a role in the mesenchymal stem cells (MSCs) maintenance. We had previously found that HA prolonged the lifespan, and prevented the cellular aging of murine adipose-derived stromal cells. Recently, we had also summarized the potential pathways associated with HA regulation in human MSCs. In this study, we used the human placenta-derived MSCs (PDMSC) to investigate the effectiveness of HA in maintaining the PDMSC. We found that coating the culture surface coated with 30 μg cm(-2) of HA (C) led to cluster growth of PDMSC, and maintained a higher number of PDMSC in quiescence compared to those grown on the normal tissue culture surface (T)...
June 2017: Aging Cell
https://www.readbyqxmd.com/read/28468030/higher-dheas-levels-associated-with-long-term-practicing-of-tai-chi
#20
Hung-Min Lai, Mark Shui-Yu Liu, Ting-Ju Lin, Ying-Lan Tsai, Eileen Jea Chien
Tai Chi has many benefits for middle-aged/older individuals including improvements to muscle strength and various body lipid components. DHEAS and testosterone have anti-obesity/anti-aging characteristics and also improve libido, vitality and immunity levels. Thus, the aim of the present study was to investigate the differences between middle-aged Tai Chi practitioners (n = 17) and sedentary individuals (n = 17) in terms of leg strength, blood levels of cholesterol, triglyceride, HDL, as well as DHEAS, testosterone and cortisol...
April 30, 2017: Chinese Journal of Physiology
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