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Jing Xu, Lin-Jiang Chen, Jian Yu, Han-Jing Wang, Fan Zhang, Qiong Liu, Jing Wu
Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an important role in the pathogenesis of DR. AGEs can exert their deleterious effects by acting directly to induce aberrant crosslinking of extracellular matrix proteins, to increase vascular stiffness, altering vascular structure and function. Moreover, AGEs binding to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal barrier (BRB), the end result of all these events is damage to the neural and vascular components of the retina...
July 19, 2018: Cellular Physiology and Biochemistry
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu
BACKGROUND/AIMS: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR). Sirt1, a prominent anti-aging player, plays pivotal roles in the DDR. However, few studies have examined alternative splicing with DNA damage in neural stem cells (NSCs) and, in essence, nothing is known about whether SIRT1 regulates alternative splicing. Hence, we investigated the potential involvement of Sirt1-mediated alternative splicing in the NSC DDR...
July 19, 2018: Cellular Physiology and Biochemistry
Francisco J Amaro-Gahete, Alejandro De-la-O, Lucas Jurado-Fasoli, Andrea Espuch-Oliver, Lidia Robles-Gonzalez, Ginés Navarro-Lomas, Tomás de Haro, Pedro Femia, Manuel J Castillo, Angel Gutierrez
Aims: The secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults...
September 2018: Contemporary Clinical Trials Communications
Christian Carpéné, Héctor Pejenaute, Raquel Del Moral, Nathalie Boulet, Elizabeth Hijona, Fernando Andrade, Maria Jesùs Villanueva-Millán, Leixuri Aguirre, José Miguel Arbones-Mainar
Phenolic compounds are among the most investigated herbal remedies, as is especially the case for resveratrol. Many reports have shown its anti-aging properties and the ability to reduce obesity and diabetes induced by high-fat diet in mice. However, such beneficial effects hardly translate from animal models to humans. The scientific community has therefore tested whether other plant phenolic compounds may surpass the effects of resveratrol. In this regard, it has been reported that piceatannol reproduces in rodents the anti-obesity actions of its parent polyphenol...
July 17, 2018: International Journal of Molecular Sciences
Sabina Ranjit, Benjamin J Patters, Kelli A Gerth, Sanjana Haque, Sanjeev Chaudhary, Santosh Kumar
Introduction HIV-1-infected smokers are at risk of oxidative damage to neuronal cells in the central nervous system by both HIV-1 and cigarette smoke. Since neurons have a weak antioxidant defense system, they mostly depend on glial cells, particularly astrocytes, for protection against oxidative damage and neurotoxicity. Astrocytes augment the neuronal antioxidant system by supplying cysteine-containing products for glutathione synthesis, antioxidant enzymes such as SOD and catalase, glucose for antioxidant regeneration via the pentose-phosphate pathway, and by recycling of ascorbic acid...
July 17, 2018: Expert Opinion on Therapeutic Targets
Muhammad Fakhar, Najumuddin, Mehreen Gul, Sajid Rashid
Klotho is an anti-aging protein that is engaged in the suppression of canonical WNT signaling. In this study, we investigated the expression pattern of human WNTs and Klotho in the pancreatic cancer. In the cancerous cells, WNT-1 exhibited much higher expression as compared to other WNTs, while no WNT expression was detected in the normal tissue. In contrast, Klotho expression was significantly low in the cancerous tissue. Based on these observations, we intended to explore Klotho binding to WNT-1 and cystein-rich domains (CRDs) of Frizzled (FZD) homologs through molecular docking and dynamics simulation assays...
July 7, 2018: Biophysical Chemistry
Feifei Liu, Hang Ma, Guihua Wang, Weixi Liu, Navindra P Seeram, Yu Mu, Yingjie Xu, Xueshi Huang, Liya Li
Published data suggest that dietary-derived phenolics exert beneficial effects against hyperglycemia-mediated diseases, such as diabetes, through inhibiting the formation of advanced glycation endproducts (AGEs) and carbohydrate hydrolyzing enzyme activities. In the course of our investigation on the edible berry, Eugenia jambolana (known as Jamun), 21 phenolics (1-21) were isolated and identified from its seeds. Among these, one compound (1) is new and eleven compounds (3, 6, 9-13, 17, and 19-21) are being reported from E...
July 16, 2018: Food & Function
Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Maat, Katsuyoshi Matsunami
ETHNOPHARMACOLOGICAL RELEVANCE: Temu giring, the rhizome of Curcuma heyneana Valeton & Zipj (C. heyneana), is native to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and body freshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer and antiinflammatory. AIM OF THE STUDY: The purpose of this study was to determine the antiaging activity of C. heyneana to prove its traditional use...
July 3, 2018: Journal of Ethnopharmacology
Laxmi Rathor, Rakesh Pandey
Oxidative damage is accrual of molecular deterioration from reactive oxygen species (ROS) while decrease in generation of ROS is related with free radical scavenging enzymes. Boerhaavia diffusa L. (Nyctaginaceae) derived novel molecule Boeravinone B (BOB) possesses a variety of pharmacological activities, yet their anti-aging potential has not been explored. The aim of the present study was to elucidate the mechanism of BOB mediated oxidative stress resistance and lifespan extension in Caenorhabditis elegans...
July 9, 2018: Experimental Gerontology
Hongyan Zhang, Zhaoyang Wang, Yanyan Li, Jiaojiao Han, Chenxi Cui, Chenyang Lu, Jun Zhou, Lingzhi Cheong, Ye Li, Tingting Sun, Dijun Zhang, Xiurong Su
Our previous work indicated that a mixture of tuna oil and algae oil treatment in male mice effectively relieved D-galactose (D-gal)-induced aging and resulted in gut microbiota alterations, and that the best anti-aging effects were observed for a tuna oil to algae oil ratio of 1:2. However, the possibility of a sex-based difference in the anti-aging effect of the tuna oil and algae oil mixture or gut microbiota variation, has rarely been investigated. In this study, the anti-aging effect of an oil mixture (1:2) in male and female mice was measured, and oil treatment improved the learning and cognition of mice that were damaged by D-gal, increased the activities of anti-oxidative enzymes, and decreased the level of MDA, which acted as a hallmark of oxidative damage to lipids...
2018: Frontiers in Aging Neuroscience
Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Hirotaka Kito, Aoi Matsubara, Mizuki Kaneda, Yu Katsuyama, Hayato Naka-Kaneda
Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic approach for geriatric disorders. The molecular mechanisms underlying age-related dysfunctions of specific types of adult tissue stem cells (TSCs) have been studied, and various microRNAs were recently reported to be involved. However, the central roles of microRNAs in stem cell aging remain unclear. Interest in this area was sparked by murine heterochronic parabiosis experiments, which demonstrated that systemic factors can restore the functions of TSCs...
2018: Inflammation and Regeneration
Eun Byeol Lee, Jun Hyeong Kim, Yeong Jee Kim, Yun Jeong Noh, Su Jin Kim, In Hyun Hwang, Dae Keun Kim
Aging is a key risk factor for many diseases, understanding the mechanism of which is becoming more important for drug development given the fast-growing aging population. In the course of our continued efforts to discover anti-aging natural products, the active constituent 6-shogaol was isolated from Zingiber officinale Roscoe. The chemical structure of 6-shogaol was identified by comparison of its NMR data with literature values. The lifespan-extending effect of 6-shogaol was observed in a dose-dependent manner in Caenorhabditis elegans that has been widely used as a model organism for human aging studies...
July 6, 2018: Archives of Pharmacal Research
Hellen E Ahrens, Judith Huettemeister, Manuel Schmidt, Christoph Kaether, Julia von Maltzahn
BACKGROUND: Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regeneration. METHODS: Here we investigate the functional role of the anti-aging hormone Klotho for muscle stem cell function after cardiotoxin-induced injury of skeletal muscle using a klotho hypomorphic mouse line, which is characterized by a premature aging phenotype...
July 4, 2018: Skeletal Muscle
L P Arantes, M L Machado, D C Zamberlan, T L da Silveira, T C da Silva, I B M da Cruz, E E Ribeiro, M Aschner, F A A Soares
Guarana (Paullinia cupana) is habitually ingested by people in the Amazon region and is a key ingredient in various energy drinks consumed worldwide. Extension in longevity and low prevalence of chronic age-related diseases have been associated to habitual intake of guarana. Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; however, the mechanisms involved in its effects are not clear. Herein, we investigated the putative pathways that regulate the effects of guarana ethanolic extract (GEE) on lifespan using C...
July 2, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Hosakatte Niranjana Murthy, Vijayalaxmi S Dandin, So-Young Park, Kee-Yoeup Paek
Ginseng (Panax ginseng C. A. Meyer, Family Araliaceae) is one of the major medicinal and nutraceutical plants, which is native to oriental region. It is used worldwide as a popular herbal medicine because of its pharmacological effects like anti-oxidative, anti aging, anti-cancer, adaptogenic, and other health-improving activities. Chief components of ginseng identified till date are ginsenosides, a group of saponins with triterpenoid structure. Ginseng is cultivated under controlled conditions, and for harvesting of fully grown roots of the plant, the cultivation takes long duration of about 5-7 years and cultivated ginseng roots are inferior in quality and ginsenoside content...
July 3, 2018: Applied Microbiology and Biotechnology
Xiao-Na Hu, Jiao-Feng Wang, Yi-Qin Huang, Zheng Wang, Fang-Yuan Dong, Hai-Fen Ma, Zhi-Jun Bao
Objective: This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells. Methods: L-02 cells were treated with a FFA mixture (oleate/palmitate, at 3:0, 2:1, 1:1, 1:2 and 0:3 ratios) at different concentrations. Cell viability and fat accumulation rate were assessed by a Cell Counting Kit 8 and Nile Red staining, respectively. The mixture with the highest cell viability and fat accumulation rate was selected to continue with the following experiment...
2018: PeerJ
Stanislovas S Jankauskas, Denis N Silachev, Nadezhda V Andrianova, Irina B Pevzner, Ljubava D Zorova, Vasily A Popkov, Egor Y Plotnikov, Dmitry B Zorov
The anti-aging strategy is one of the main challenges of the modern biomedical science. The term "aging" covers organisms, cells, cellular organelles and their constituents. In general term, aging system admits the existence of nonfunctional structures which by some reasons have not been removed by a clearing system, e.g., through autophagy/mitophagy marking and destroying unwanted cells or mitochondria. This directly relates to the old kidney which normal functioning is critical for the viability of the organism...
July 2, 2018: Cell Cycle
Yujuan Li, Shiyuan Wang, Yizhou Xin, Mengmeng Zheng, Fangxue Xu, Xiaozhi Xi, Hui Cao, Xiaowei Cui, Hong Guo, Chunchao Han
Herbal cosmetics are the focus of attention nowadays, they have various therapeutics, including, anti-oxidant, anti-radiation, anti-aging, anti-inflammatory. Maca contains polysaccharides, phenolics, alkaloids, minerals and amino acids, which is said to suitable component for cosmetics due to the single action or synergy action. The review summarized the existed and potential therapeutic effects of maca ingredients in cosmetics. And compared to the marketed cosmetics, maca cosmetics have the merits of mild, low-toxicity and the clear relationship efficacy...
2018: Journal of Oleo Science
Handan Melike Dönertaş, Matías Fuentealba Valenzuela, Linda Partridge, Janet M Thornton
Ageing is the largest risk factor for a variety of non-communicable diseases. Model organism studies have shown that genetic and chemical perturbations can extend both life- and health-span. Ageing is a complex process, with parallel and interacting mechanisms contributing to its aetiology, posing a challenge for the discovery of new pharmacological candidates to ameliorate its effects. In this study, instead of a target-centric approach, we adopt a systems level drug repurposing methodology to discover drugs that could combat ageing in human brain...
June 30, 2018: Aging Cell
Gregorio Peron, Stefano Dall'Acqua, Stefania Sut
An UPLC-HR-MS metabolomics approach was used to study the effects of a 49-days oral supplementation with Polygonum cuspidatum extract in healthy rats. Multivariate analysis allowed to observe significant differences in the excretion of several markers between treated animals and control group. Among the others, the amounts of N-methyl-2-pyridone-5-carboxamide (2PY) and phenylacetylglycine (PAG) were reduced in the treated group compared to control. These compounds have been previously considered as markers of aging...
June 27, 2018: Fitoterapia
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