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Nephropathy, diabetes, hypertension, CKD

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https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#1
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29190866/-chronic-kidney-disease-in-mexico-and-its-relation-with-heavy-metals
#2
Nancy Libertad Chávez-Gómez, Alejandro Cabello-López, Rodrigo Gopar-Nieto, Guadalupe Aguilar-Madrid, Kennia Stephanie Marin-López, Maricruz Aceves-Valdez, Carmina Jiménez-Ramírez, María Cruz-Angulo, Cuauhtémoc Arturo Juárez-Pérez
Chronic kidney disease (CKD) is a public health problem in Mexico, causing 25% of deaths related to diabetes mellitus (DM) and 28% related to hypertensive heart disease. In 2008 CKD reached the highest incidence of end-stage renal disease in the world. Diabetes mellitus is the main risk factor associated with CKD in Mexican population; however, heavy metals such as lead, arsenic, cadmium and mercury have been associated to nephropathies. In Mexico there are still high levels of these compounds in occupational and environmental settings; therefore, chronic exposures to these metals persist...
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29127556/nationwide-multicenter-kidney-biopsy-study-of-japanese-patients-with-hypertensive-nephrosclerosis
#3
Kengo Furuichi, Miho Shimizu, Yukio Yuzawa, Akinori Hara, Tadashi Toyama, Hiroshi Kitamura, Yoshiki Suzuki, Hiroshi Sato, Noriko Uesugi, Yoshifumi Ubara, Junichi Hoshino, Satoshi Hisano, Yoshihiko Ueda, Shinichi Nishi, Hitoshi Yokoyama, Tomoya Nishino, Kentaro Kohagura, Daisuke Ogawa, Koki Mise, Yugo Shibagaki, Kenjiro Kimura, Masakazu Haneda, Hirofumi Makino, Seiichi Matsuo, Takashi Wada
BACKGROUND: Nephrosclerosis is an increasingly reason for dialysis in Japan. However, kidney biopsy specimens for hypertensive nephrosclerosis are very limited; thus, the pathologic evaluation of hypertensive nephrosclerosis currently remains unclear. METHODS: Clinical and pathologic data of a total of 184 biopsy-confirmed hypertensive nephrosclerosis patients were collected from 13 centers throughout Japan. Seven pathological findings were assessed in this study...
November 11, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29106632/cost-effectiveness-of-screening-type-2-diabetes-patients-for-chronic-kidney-disease-progression-with-the-ckd273-urinary-peptide-classifier-as-compared-to-urinary-albumin-excretion
#4
Elena Critselis, Antonia Vlahou, Vianda S Stel, Rachael L Morton
Background: In type 2 diabetes mellitus (T2DM) patients, chronic kidney disease (CKD) progression may occur without detectable changes in urinary albumin excretion (UAE) rate. A new urinary peptide classifier (CKD273) has exhibited greater ability to detect CKD progression, however, its cost-effectiveness remains unknown. This study evaluated the cost-effectiveness of screening for CKD progression with the CKD273 classifier, as compared to UAE, in diabetic patients. Methods: A decision-analytic Markov model was developed to estimate costs and health outcomes [including overall survival and quality-adjusted life years (QALYs)] from a health system perspective for adopting a new annual screening strategy based on the CKD273 classifier as compared to annual UAE-based screening in a hypothetical cohort of T2DM patients...
July 3, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28993503/myh9-e1841k-mutation-augments-proteinuria-and-podocyte-injury-and-migration
#5
Sylvia Cechova, Fan Dong, Fang Chan, Michael J Kelley, Phillip Ruiz, Thu H Le
Intronic variants of the MYH9 gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle cell disease-associated nephropathy. However, the causal functional variants of MYH9 have remained elusive. Rare missense mutations in MYH9 cause macrothrombocytopenia and are occasionally associated with development of nephropathy. The E1841K mutation is among the common MYH9 missense mutations and has been associated with nephropathy in some carriers...
October 9, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28989092/advanced-liver-fibrosis-but-not-steatosis-is-independently-associated-with-albuminuria-in-chinese-patients-with-type-2-diabetes
#6
Ming-Wai Yeung, Grace Lai-Hung Wong, Kai Chow Choi, Andrea On-Yan Luk, Raymond Kwok, Sally She-Ting Shu, Anthony Wing-Hung Chan, Eric Siu Him Lau, Ronald Ching Wan Ma, Henry Lik-Yuen Chan, Juliana Chung-Ngor Chan, Vincent Wai-Sun Wong, Alice Pik-Shan Kong
BACKGROUND & AIMS: Increasing evidence suggests that non-alcoholic fatty liver disease (NAFLD) may be an independent risk factor for chronic kidney disease (CKD). Given the high prevalence of NAFLD among patients with diabetes who are also at risk of CKD, we aimed to investigate the association between NAFLD and albuminuria, a marker commonly found in diabetic nephropathy. METHODS: This study included a cohort of Chinese patients with type 2 diabetes from the Hong Kong Diabetes Registry recruited between March 2013 and May 2014...
October 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28869129/-characteristics-and-cardiovascular-events-in-a-general-population-included-in-the-ricarto-riesgo-cardiovascular-toledo-study-data-from-the-first-1-500-individuals-included-in-the-study
#7
G C Rodríguez-Roca, A Segura-Fragoso, A Villarín-Castro, F J Alonso-Moreno, L Rodríguez-Padial, M L Rodríguez-García, J A Fernández-Conde, G A Rojas-Martelo, A Menchén-Herreros, C Escobar-Cervantes, J Fernández-Martín, L M Artigao-Rodenas, J A Carbayo-Herencia, J Hernández-Moreno
INTRODUCTION: The aim of this study was to assess cardiovascular risk (CVR) by investigating the prevalence of CVR factors (CVRF), target organ damage (TOD), and cardiovascular disease (CVD) in general population of the health area of Toledo, Spain. MATERIAL AND METHODS: Epidemiological and observational study that analysed a sample from the general population aged 18years or older, randomly selected from a database of health cards stratified by age and gender. Clinical history, physical examination, and complementary tests were performed...
August 28, 2017: Semergen
https://www.readbyqxmd.com/read/28860163/proximal-tubular-cannabinoid-1-receptor-regulates-obesity-induced-ckd
#8
Shiran Udi, Liad Hinden, Brian Earley, Adi Drori, Noa Reuveni, Rivka Hadar, Resat Cinar, Alina Nemirovski, Joseph Tam
Obesity-related structural and functional changes in the kidney develop early in the course of obesity and occur independently of hypertension, diabetes, and dyslipidemia. Activating the renal cannabinoid-1 receptor (CB1R) induces nephropathy, whereas CB1R blockade improves kidney function. Whether these effects are mediated via a specific cell type within the kidney remains unknown. Here, we show that specific deletion of CB1R in the renal proximal tubule cells did not protect the mice from obesity, but markedly attenuated the obesity-induced lipid accumulation in the kidney and renal dysfunction, injury, inflammation, and fibrosis...
August 31, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28834376/nephropathies
#9
EDITORIAL
A Westphal, S Reuter, R Mrowka
No abstract text is available yet for this article.
November 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28820061/renin-angiotensin-system-and-cytokines-in-chronic-kidney-disease-clinical-and-experimental-evidence
#10
Ariadna Andrade Saldanha da Silva, Thiago Ruiz Prestes, Amanda Oliveira Lauar, Beranardo Bahia Finotti, Ana Cristina Simões e Silva
Chronic kidney disease (CKD) has become a major public health problem in Brazil and worldwide. There are many causes of CKD, being the congenital anomalies of the kidney and urinary tract and the glomerular diseases very common in pediatric patients, while diabetic nephropathy, CKD due to chronic arterial hypertension and glomerular diseases are predominant in adult patients. Many endogenous mediators have been related to the pathophysiology of CKD, being relevant the effects of the renin-angiotensin system (RAS) and the immune-inflammatory mediators including cytokines...
August 18, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28750501/the-current-management-of-kidney-disease-in-the-elderly
#11
Agnieszka Perkowska-Ptasinska, Dominika Deborska-Materkowska, Magdalena Durlik
CKD, diabetes and cardiovascular disease constitute three interrelated conditions of strong public health relevance. Elderly individuals account for the largest and the most rapidly growing age segment of the ESRD population. The elderly are affected by the same types of kidney diseases as younger individuals, but aging itself is associated with a gradual reduction in eGFR, which leads to the diminishment of the functional reserve and makes an individual more vulnerable to injurious effects of hypertension, cardiovascular disease, diabetes, and drugs' toxicity...
July 27, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28722618/clinical-evidence-of-acute-mesoamerican-nephropathy
#12
Rebecca S B Fischer, Sreedhar Mandayam, Denis Chavarria, Chandan Vangala, Melissa S Nolan, Linda L Garcia, Lesbia Palma, Felix Garcia, Ramón García-Trabanino, Kristy O Murray
Mesoamerican nephropathy (MeN), an epidemic of unexplained kidney disease in Central America, affects mostly young, healthy individuals. Its etiology is a mystery that requires urgent investigation. Largely described as a chronic kidney disease (CKD), no acute clinical scenario has been characterized. An understanding of the early disease process could elucidate an etiology and guide treatment and prevention efforts. We sought to document the earliest clinical signs in patients with suspected MeN in a high-risk population in Nicaragua...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28701959/renal-oxygenation-in-the-pathophysiology-of-chronic-kidney-disease
#13
REVIEW
Zhi Zhao Liu, Alexander Bullen, Ying Li, Prabhleen Singh
Chronic kidney disease (CKD) is a significant health problem associated with high morbidity and mortality. Despite significant research into various pathways involved in the pathophysiology of CKD, the therapeutic options are limited in diabetes and hypertension induced CKD to blood pressure control, hyperglycemia management (in diabetic nephropathy) and reduction of proteinuria, mainly with renin-angiotensin blockade therapy. Recently, renal oxygenation in pathophysiology of CKD progression has received a lot of interest...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28667063/translational-science-in-chronic-kidney-disease
#14
REVIEW
Maria Dolores Sanchez-Niño, Ana B Sanz, Adrian M Ramos, Marta Ruiz-Ortega, Alberto Ortiz
The KDIGO definition of chronic kidney disease (CKD) allowed a more detailed characterization of CKD causes, epidemiology and consequences. The picture that has emerged is worrisome from the point of view of translation. CKD was among the fastest growing causes of death in the past 20 years in age-adjusted terms. The gap between recent advances and the growing worldwide mortality appears to result from sequential roadblocks that limit the flow from basic research to clinical development (translational research type 1, T1), from clinical development to clinical practice (translational research T2) and result in deficient widespread worldwide implementation of already available medical advances (translational research T3)...
July 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28643820/does-wealth-make-health-cherchez-la-renal-replacement-therapy
#15
COMMENT
Maria D Sanchez-Niño, Alberto Ortiz
In this issue of CKJ, McQuarrie et al. have explored the relationship between socioeconomic status and outcomes among Scottish patients with a renal biopsy diagnosis of primary glomerulonephritis. Patients in the lower socioeconomic category had a twofold higher risk of death. No significant differences were observed on progression to end-stage renal disease (ESRD) requiring renal replacement therapy (RRT), suggesting that overall medical management was appropriate for all socioeconomic categories. The findings are significant since they come from an ethnically homogeneous population with free access to healthcare; they also relate to a specific aetiology of chronic kidney disease (CKD) expected to be less dependent on unhealthy lifestyles than other more frequent aetiologies that dominate studies of CKD in general, such as diabetic or hypertensive nephropathy...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28469119/blood-pressure-variation-and-its-correlates-among-patients-undergoing-hemodialysis-for-renal-failure-in-benin-city-nigeria
#16
Enajite I Okaka, Chimezie G Okwuonu
BACKGROUND: Blood pressure (BP) variation is commonly encountered during hemodialysis (HD) procedure. Both intradialysis hypotension and hypertension have implications for outcome of treatment and overall morbidity and mortality of the patients. METHODOLOGY: A retrospective study was carried out in the dialysis unit of a tertiary health institution in Benin City among patients who had HD for acute kidney injury (AKI) or chronic kidney disease (CKD) over a 3-year period...
April 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28426518/pathophysiologic-insight-into-mesoamerican-nephropathy
#17
Magdalena Madero, Fernando E García-Arroyo, Laura-Gabriela Sánchez-Lozada
PURPOSE OF REVIEW: Mesoamerican nephropathy (MeN) is an emerging pathophysiological entity of Chronic kidney desease (CKD) not related to traditional risk factors (diabetes and hypertension) that have caused thousands of deaths in Central America, mainly in sugarcane workers. The focus of this review is to discuss the risk factors and probable mechanisms involved in the initiation and progression of this devastating disease. RECENT FINDINGS: Frequent episodes of subclinical Acute kidney injury caused by repetitive heat stress, dehydration, and strenuous work have been regarded as the main risk factors for MeN...
July 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28413960/circulating-ace2-in-cardiovascular-and-kidney-diseases
#18
Lidia Anguiano, Marta Riera, Julio Pascual, María José Soler
Angiotensin converting enzyme(ACE) 2 is a homologue of ACE that catalyzes the conversion of Angiotensin(Ang) II into Ang1-7, which induces vasodilation, anti-fibrotic, anti-proliferative and anti-inflammatory effects. Given that ACE2 counterbalances the effects of Ang II, it has been proposed as a biomarker in kidney disease patients. Circulating ACE2 has been studied in human and experimental studies under physiological and pathological conditions and different techniques have been assessed to determine its enzymatic activity...
April 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28355395/obesity-and-kidney-disease
#19
Geraldo Bezerra da Silva Junior, Ana Carla Sobral Novaes Bentes, Elizabeth De Francesco Daher, Sheila Maria Alvim de Matos
Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity are important risk factors for chronic kidney disease (CKD). Obesity influences CKD development, among other factors, because it predisposes to diabetic nephropathy, hypertensive nephrosclerosis and focal and segmental glomerulosclerosis. Excess weight and obesity are associated with hemodynamic, structural and histological renal changes, in addition to metabolic and biochemical alterations that lead to kidney disease...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28340010/non-proteinuric-rather-than-proteinuric-renal-diseases-are-the-leading-cause-of-end-stage-kidney-disease
#20
MULTICENTER STUDY
Davide Bolignano, Carmine Zoccali
Proteinuria is a distinguishing feature in primary and secondary forms of chronic glomerulonephritis, which contribute to no more than the 20% of the end-stage kidney disease (ESKD) population. The contribution of non-proteinuric nephropathies to the global ESKD burden is still poorly focused and scarce research efforts are dedicated to the elucidation of risk factors and mechanistic pathways triggering ESKD in these diseases. We abstracted information on proteinuria in the main renal diseases other than glomerulonephritides that may evolve into ESKD...
April 1, 2017: Nephrology, Dialysis, Transplantation
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