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Nephropathy, diabetes, hypertension, CKD

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https://www.readbyqxmd.com/read/27884230/the-kidney-in-hypertension
#1
REVIEW
Hillel Sternlicht, George L Bakris
Hypertension is the second most common cause of chronic kidney disease (CKD) and is a potentiator of kidney failure when accompanying disease. CKD is a common cause of resistant hypertension. Nephropathy progression has dramatically slowed over the past 3 decades from an average of 8 to between 2-3 mL/min per year regardless of diabetes status. The incidence of very high albuminuria as well as progression from high albuminuria very high albuminuria has substantially decreased over the past 3 decades. This improvement relates to better blood pressure control using agents that slow nephropathy as well as better glycemic and cholesterol control...
January 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/27833523/role-of-cytogenetic-biomarkers-in-management-of-chronic-kidney-disease-patients-a-review
#2
REVIEW
Zeba Khan, Manoj Pandey, Ravindra M Samartha
Chronic kidney disease (CKD) is much more common than people recognize, and habitually goes undetected and undiagnosed until the disease is well advanced or when their kidney functions is down to 25% of normal function. Genetic and non-genetic factors contribute to cause CKD. Non-genetic factors include hypertension, High level of DNA damage due to the production of reactive oxygen species and nucleic acid oxidation has been reported in CKD patients. Main genetic factor which causes CKD is diabetic nephropathy...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27809790/fatal-outcomes-among-patients-on-maintenance-haemodialysis-in-sub-saharan-africa-a-10-year-audit-from-the-douala-general-hospital-in-cameroon
#3
Marie Patrice Halle, Gloria Ashuntantang, Francois Folefack Kaze, Christian Takongue, Andre-Pascal Kengne
BACKGROUND: End-Stage Renal disease (ESRD) is associated with increased morbidity and mortality. We assessed the occurrence, time-trend and determinants of fatal outcomes of haemodialysis-treated ESRD patients over a 10-year period in a major referral hospital in Cameroon. METHODS: Medical records of ESRD patients who started chronic haemodialysis at the Douala General Hospital between 2002 and 2012 were reviewed. Baseline characteristics and fatal outcomes on dialysis were recorded...
November 3, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27754167/sy-12-3-are-ras-inhibitors-necessary-for-all-patients-with-diabetes-and-chronic-kidney-disease
#4
Shokei Kim-Mitsuyama
There is accumulating evidence that RAS inhibitors not only reduce blood pressure, but also exert pleiotropic effects, including a renoprotective effect, amelioration of insulin resistance, reduction in onset of diabetes, and suppression of cardiovascular remodelling,. However, the definite benefit of RAS inhibition in treatment of hypertension with CKD or DM is not conclusive. We previously performed the OlmeSartan and Calcium Antagonists Randomized (OSCAR) study comparing the preventive effect of high-dose ARB therapy versus ARB plus CCB combination therapy on cardiovascular morbidity and mortality in 1164 Japanese elderly hypertensive patients with baseline type 2 diabetes and/or CVD (Am J Med (2012))...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754015/br-04-1management-of-treatment-resistant-hypertension
#5
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753857/sp-01-1-aldosterone-antagonists-for-the-treatment-of-hypertensive-nephropathy
#6
Toshiro Fujita
The aldosterone/mineralocorticoid receptor (MR) pathway regulate renal excretory function and control BP. Notably, we identified Rac1 as a novel ligand-independent modulator of MR (Nat Med 2008), and found involvement of the Rac1-MR pathway in rodent models of salt-sensitive hypertension (JCI 2011). In the clinical trial (EVALUATE study), effects of MR antagonist on urinary albumin excretion were assessed in 304 hypertensive CKD patients receiving renin-angiotensin system (RAS) inhibitors and sub-grouped according to the estimated dietary salt intake (Lancet Endo & Diabetes 2014)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27721548/prescribing-patterns-of-medicines-in-chronic-kidney-disease-patients-on-maintenance-hemodialysis
#7
Sourav Chakraborty, Saugata Ghosh, Avishek Banerjea, Radha Raman De, Avijit Hazra, Swapan Kumar Mandal
OBJECTIVES: To study medicine prescribing pattern for chronic kidney disease (CKD) patients on maintenance hemodialysis. MATERIALS AND METHODS: This prospective observational study was conducted in hemodialysis unit of a teaching hospital with adult CKD patients on maintenance hemodialysis. Patients' clinical profile, drug-use pattern, and medication-related problem data were captured in a structured case report form and the data were analyzed descriptively. Adherence level was assessed by Morisky Medication-Taking Adherence Scale 4-item...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27649693/vegan-vegetarian-low-protein-supplemented-diets-in-pregnant-ckd-patients-fifteen-years-of-experience
#8
Rossella Attini, Filomena Leone, Silvia Parisi, Federica Fassio, Irene Capizzi, Valentina Loi, Loredana Colla, Maura Rossetti, Martina Gerbino, Stefania Maxia, Maria Grazia Alemanno, Fosca Minelli, Ettore Piccoli, Elisabetta Versino, Marilisa Biolcati, Paolo Avagnina, Antonello Pani, Gianfranca Cabiddu, Tullia Todros, Giorgina B Piccoli
BACKGROUND: Pregnancy in women with advanced CKD becoming increasingly common. However, experience with low-protein diets in CKD patients in pregnancy is still limited. Aim of this study is to review the results obtained over the last 15 years with moderately restricted low-protein diets in pregnant CKD women (combining: CKD stages 3-5, proteinuria: nephrotic at any time, or > =1 g/24 at start or referral; nephrotic in previous pregnancy). CKD patients on unrestricted diets were employed for comparison...
September 20, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27643122/sy-12-3-are-ras-inhibitors-necessary-for-all-patients-with-diabetes-and-chronic-kidney-disease
#9
Shokei Kim-Mitsuyama
There is accumulating evidence that RAS inhibitors not only reduce blood pressure, but also exert pleiotropic effects, including a renoprotective effect, amelioration of insulin resistance, reduction in onset of diabetes, and suppression of cardiovascular remodelling,. However, the definite benefit of RAS inhibition in treatment of hypertension with CKD or DM is not conclusive. We previously performed the OlmeSartan and Calcium Antagonists Randomized (OSCAR) study comparing the preventive effect of high-dose ARB therapy versus ARB plus CCB combination therapy on cardiovascular morbidity and mortality in 1164 Japanese elderly hypertensive patients with baseline type 2 diabetes and/or CVD (Am J Med (2012))...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643094/sp-01-1-aldosterone-antagonists-for-the-treatment-of-hypertensive-nephropathy
#10
Toshiro Fujita
The aldosterone/mineralocorticoid receptor (MR) pathway regulate renal excretory function and control BP. Notably, we identified Rac1 as a novel ligand-independent modulator of MR (Nat Med 2008), and found involvement of the Rac1-MR pathway in rodent models of salt-sensitive hypertension (JCI 2011). In the clinical trial (EVALUATE study), effects of MR antagonist on urinary albumin excretion were assessed in 304 hypertensive CKD patients receiving renin-angiotensin system (RAS) inhibitors and sub-grouped according to the estimated dietary salt intake (Lancet Endo & Diabetes 2014)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642926/br-04-1management-of-treatment-resistant-hypertension
#11
David John Webb
Treatment-resistant hypertension (TRH) is defined as the failure to achieve an office BP target of <140/90 mmHg (<130/80 mmHg in patients with chronic kidney disease (CKD) or diabetes) in patients with hypertension (HT), despite adherence to at least 3 antihypertensive medications at optimal tolerated doses, ideally including a diuretic (Calhoun et al., Circulation 2008). TRH identifies patients with hard-to-treat HT, who might benefit from specialist investigation and treatment. Although some studies put the prevalence of TRH as >10%, these levels may be inflated by white-coat hypertension and poor adherence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27548687/patiromer-the-first-potassium-binder-approved-in-over-50-years
#12
Betty N Vu, Alyssa Mae De Castro, David Shottland, William H Frishman, Angela Cheng-Lai
For over 50 years, there have been limited options for the management of hyperkalemia, especially among patients with chronic kidney disease (CKD), diabetic nephropathy, hypertension, and heart failure, who were receiving concomitant renin-angiotensin-aldosterone system (RAAS) inhibitor therapy. Hyperkalemia is a potential, life-threatening electrolyte abnormality that frequently challenges clinicians from maximizing the mortality benefit and organ-protective properties of RAAS inhibitors especially in CKD and heart failure populations...
November 2016: Cardiology in Review
https://www.readbyqxmd.com/read/27520943/emerging-therapeutics-for-the-treatment-of-diabetic-nephropathy
#13
REVIEW
Jehrod Brenneman, Jon Hill, Steve Pullen
Diabetic nephropathy (DN) is the most common pathology contributing to the development of chronic kidney disease (CKD). DN caused by hypertension and unmitigated inflammation in diabetics, renders the kidneys unable to perform normally, and leads to renal fibrosis and organ failure. The increasing global prevalence of DN has been directly attributed to rising incidences of Type II diabetes, and is now the largest non-communicable cause of death worldwide. Despite the high morbidity, successful new treatments for DN are lacking...
September 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27508628/-op-2b-09-patients-with-advanced-kidney-disease-and-nephroangiosclerosis-might-not-benefit-of-strict-blood-pressure-control
#14
S Vettoretti, L Caldiroli, V Azzini, R Meazza, A Villarini, M Marcucci, C Alfieri, P Messa
OBJECTIVE: Blood pressure (BP) targets in chronic kidney disease (CKD) may differ in accordance with the etiology of CKD. We investigated if BP targets recommended by 2013 ESH guidelines for CKD patients are equally effective in subjects with nephroangiosclerosis (NAS+) respect to those with other nephropathies (NAS-). DESIGN AND METHOD: We analyzed 148 hypertensive patients with CKD (stages 3b-4), NAS+ (n = 66) and NAS- (n = 82). We collected at two visits: anamnesis, BP, blood and 24 h urinary samples...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27397961/chronic-kidney-disease-in-nigeria-late-presentation-is-still-the-norm
#15
Oluseyi A Adejumo, Ayodeji A Akinbodewa, Enajite I Okaka, Oladimeji E Alli, Ifedayo F Ibukun
BACKGROUND: Chronic kidney disease (CKD) has become a public health problem in Nigeria. Efforts are being geared toward early diagnosis and prevention of CKD. This study involved the evaluation of the referral pattern and mode of presentation of CKD patients at first contact in a tertiary health institution. PATIENTS AND METHODS: Patients' records over an 18 month period were retrieved and the following information extracted: Sociodemographic data, referral hospital, mode of presentation, etiology of CKD, packed cell volume, blood pressure, and estimated glomerular filtration rate (GFR) at first presentation...
May 2016: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/27310973/prevalence-awareness-and-treatment-of-anemia-in-chinese-patients-with-nondialysis-chronic-kidney-disease-first-multicenter-cross-sectional-study
#16
Ya Li, Hao Shi, Wei-Ming Wang, Ai Peng, Geng-Ru Jiang, Jin-Yuan Zhang, Zhao-Hui Ni, Li-Qun He, Jian-Ying Niu, Nian-Song Wang, Chang-Lin Mei, Xu-Dong Xu, Zhi-Yong Guo, Wei-Jie Yuan, Hai-Dong Yan, Yue-Yi Deng, Chen Yu, Jun Cen, Yun Zhang, Nan Chen
This was the first multicenter, cross-sectional survey to assess the prevalence of anemia, patient awareness, and treatment status in China. Data of patients with chronic kidney disease (CKD; age, 18-75 years; both out- and inpatients) from 25 hospitals in Shanghai, seeking medical treatment at the nephrology department, were collected between July 1, 2012 and August 31, 2012. The prevalence, awareness, and treatment of anemia in patients with nondialysis CKD (ND-CKD) were assessed. Anemia was defined as serum hemoglobin (Hb) levels ≤12 g/dL in women and ≤13 g/dL in men...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27209436/incidence-mortality-and-prevalence-of-end-stage-chronic-renal-disease-in-the-bajo-lempa-region-of-el-salvador-a-ten-year-community-registry
#17
Ramón García-Trabanino, Carolina Hernández, Adrián Rosa, Jesús Domínguez Alonso
: The Bajo Lempa is an impoverished rural coastal region of El Salvador affected by the chronic kidney disease (CKD) epidemic known as Mesoamerican nephropathy. The local community organisation Fondo Social de Emergencia para la Salud (FSES) (Emergency social fund for health) is helping to fight the epidemic in 42 communities of the region (19,223 inhabitants; average age 26.7 years; 48.5% male; 40.2% <18 years). OBJECTIVES: To report annual rates of end-stage renal disease (ESRD) incidence and patient mortality in these communities during a 10-year period (2004-2013), and the prevalence of patients receiving renal replacement therapy (RRT) as of 31 December 2013...
May 18, 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27152261/soy-based-renoprotection
#18
REVIEW
Nancy J McGraw, Elaine S Krul, Elizabeth Grunz-Borgmann, Alan R Parrish
Chronic kidney disease (CKD) is a significant public health problem as risk factors such as advanced age, obesity, hypertension and diabetes rise in the global population. Currently there are no effective pharmacologic treatments for this disease. The role of diet is important for slowing the progression of CKD and managing symptoms in later stages of renal insufficiency. While low protein diets are generally recommended, maintaining adequate levels of intake is critical for health. There is an increasing appreciation that the source of protein may also be important...
May 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27151892/climate-change-and-the-emergent-epidemic-of-ckd-from-heat-stress-in-rural-communities-the-case-for-heat-stress-nephropathy
#19
Jason Glaser, Jay Lemery, Balaji Rajagopalan, Henry F Diaz, Ramón García-Trabanino, Gangadhar Taduri, Magdalena Madero, Mala Amarasinghe, Georgi Abraham, Sirirat Anutrakulchai, Vivekanand Jha, Peter Stenvinkel, Carlos Roncal-Jimenez, Miguel A Lanaspa, Ricardo Correa-Rotter, David Sheikh-Hamad, Emmanuel A Burdmann, Ana Andres-Hernando, Tamara Milagres, Ilana Weiss, Mehmet Kanbay, Catharina Wesseling, Laura Gabriela Sánchez-Lozada, Richard J Johnson
Climate change has led to significant rise of 0.8°C-0.9°C in global mean temperature over the last century and has been linked with significant increases in the frequency and severity of heat waves (extreme heat events). Climate change has also been increasingly connected to detrimental human health. One of the consequences of climate-related extreme heat exposure is dehydration and volume loss, leading to acute mortality from exacerbations of pre-existing chronic disease, as well as from outright heat exhaustion and heat stroke...
August 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27097221/beneficial-effects-of-sarpogrelate-and-rosuvastatin-in-high-fat-diet-streptozotocin-induced-nephropathy-in-mice
#20
Dong-Hyun Kim, Bo-Hyun Choi, Sae-Kwang Ku, Jeong-Hyeon Park, Euichaul Oh, Mi-Kyoung Kwak
Chronic kidney disease (CKD) is a major complication of metabolic disorders such as diabetes mellitus, obesity, and hypertension. Comorbidity of these diseases is the factor exacerbating CKD progression. Statins are commonly used in patients with metabolic disorders to decrease the risk of cardiovascular complications. Sarpogrelate, a selective antagonist of 5-hydroxytryptamine (5-HT) 2A receptor, inhibits platelet aggregation and is used to improve peripheral circulation in diabetic patients. Here, we investigated the effects of sarpogrelate and rosuvastatin on CKD in mice that were subjected to a high fat diet (HFD) for 22 weeks and a single low dose of streptozotocin (STZ, 40 mg/kg)...
2016: PloS One
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