Montse Guardiola, Pere Rehues, Núria Amigó, Francisco Arrieta, Manuel Botana, José A Gimeno-Orna, Josefa Girona, José Ignacio Martínez-Montoro, Emilio Ortega, Antonio Pérez-Pérez, Víctor Sánchez-Margalet, Juan Pedro-Botet, Josep Ribalta
The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between dyslipidaemia and atherosclerosis in T2DM is complex, and our contention is that a deeper understanding of lipoprotein composition and functionality, the vehicle that delivers cholesterol to the artery, will provide insight for improving our understanding of the hidden cardiovascular risk of diabetes...
April 13, 2024: European Journal of Clinical Investigation