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https://www.readbyqxmd.com/read/27915092/acupuncture-ameliorates-inflammatory-response-in-a-chronic-unpredictable-stress-rat-model-of-depression
#1
Jun Lu, Run-Hui Shao, Shu-Ying Jin, Li Hu, Ya Tu, Jian-You Guo
Depression is one of the most common psychiatric disorders. Chronic inflammatory response has been viewed as a key factor in depression. Acupuncture in Chinese medicine has been shown to be an effective treatment for depression. In the present study, we investigated the mechanism underlying antidepressant effect of acupuncture. The rats were subjected to chronic unpredictable mild stress (CUMS) for 28days to induce depressive-like behaviors. Acupuncture treatment was applied once every other day during the 28-day stress period...
November 30, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27910216/capillary-electrophoresis-as-tool-for-diastereomeric-separation-in-a-trichilia-catigua-fraction
#2
Ana Luiza Sereia, Renata Longhini, Gisely Cristiny Lopes, João Carlos Palazzo de Mello
INTRODUCTION: The tree Trichilia catigua, popularly known as "catuaba", shows several biological activities and has emerged as a potential source of new drugs. Considering that more than 10 species are known under the same popular name, regulatory agencies require more rigorous quality control of this medicinal plant. OBJECTIVE: To develop and validate a methodology using capillary electrophoresis (CE) with ultraviolet (UV) detection for analysing polyphenols in the ethyl-acetate fraction (EAF) of Trichilia catigua...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27905929/smoking-cessation-programmes-using-traditional-medicine-in-korea
#3
Soobin Jang, Yu Lee Park, Ju Ah Lee, Kyeong Han Kim, Eun-Kyoung Lee, Seung-Ho Sun, Yong-Cheol Shin, Seong-Gyu Ko, Sunju Park
BACKGROUND: There are growing interests in using various methods including traditional and complementary medicines (T&CM) for tobacco control. The study aimed to introduce how traditional Korean medicine (TKM) applied to smoking cessation programmes in Korea and to show the detail information of each programme for designing other smoke cessation programmes. METHODS: Reports of the smoke cessation programmes in Korea were searched on March 10th, 2016, from the webpages of the related agencies and the databases: the Ministry of Health and Welfare, the Korea Health Foundation, the Association of Korean Medicine, PubMed, Google scholar, the RISS, the KISS, the NDSL, and the OASIS...
December 1, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#4
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896909/homeless-patients-perceptions-about-using-cell-phones-to-manage-medications-and-attend-appointments
#5
Leticia R Moczygemba, Lauren S Cox, Samantha A Marks, Margaret A Robinson, Jean-Venable R Goode, Nellie Jafari
OBJECTIVES: The objectives of this study were to (1) describe homeless persons' access and use of cell phones and their perceptions about using cell phone alerts to help manage medications and attend health care appointments and (2) identify demographic characteristics, medication use and appointment history and perceptions associated with interest in receiving cell phone alerts to manage medications and appointments. METHODS: A cross-sectional survey was conducted in 2013 at a homeless clinic in Virginia...
November 29, 2016: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27890390/world-association-of-sleep-medicine-wasm-2016-standards-for-recording-and-scoring-leg-movements-in-polysomnograms-developed-by-a-joint-task-force-from-the-international-and-the-european-restless-legs-syndrome-study-groups-irlssg-and-eurlssg
#6
R Ferri, S Fulda, R P Allen, M Zucconi, O Bruni, S Chokroverty, L Ferini-Strambi, B Frauscher, D Garcia-Borreguero, M Hirshkowitz, B Högl, Y Inoue, A Jahangir, M Manconi, C L Marcus, D L Picchietti, G Plazzi, J W Winkelman, R S Zak
This report presents the results of the work by a joint task force of the International and European Restless Legs Syndrome Study Groups and World Association of Sleep Medicine that revised and updated the current standards for recording and scoring leg movements (LM) in polysomnographic recordings (PSG). First, the background of the decisions made and the explanations of the new rules are reported and then specific standard rules are presented for recording, detecting, scoring and reporting LM activity in PSG...
November 7, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27887680/emergency-video-telemedicine-consultation-for-newborn-resuscitations-the-mayo-clinic-experience
#7
Jennifer L Fang, Christopher A Collura, Robert V Johnson, Garth F Asay, William A Carey, Douglas P Derleth, Tara R Lang, Beth L Kreofsky, Christopher E Colby
OBJECTIVE: To describe the Mayo Clinic experience with emergency video telemedicine consultations for high-risk newborn deliveries. PATIENTS AND METHODS: From March 26, 2013, through December 31, 2015, the Division of Neonatal Medicine offered newborn telemedicine consultations to 6 health system sites. A wireless tablet running secure video conferencing software was used by the local care teams. Descriptive data were collected on all consultations. After each telemedicine consult, a survey was sent to the neonatologist and referring provider to assess the technology, teamwork, and user satisfaction...
December 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27885674/gender-differences-in-the-use-of-complementary-and-alternative-medicine-and-their-association-with-moderate-mental-distress-in-u-s-adults-with-migraines-severe-headaches
#8
Taeho Greg Rhee, Ila M Harris
OBJECTIVE: We examined whether the prevalence of complementary and alternative medicine (CAM) use varies by gender, and assessed the interaction of gender and CAM use on moderate mental distress (MMD) in U.S. adults with migraines/severe headaches. METHODS: We used data from the 2012 National Health Interview Survey, which represents non-institutionalized U.S. adults with migraines/severe headaches (n = 4645 unweighted). Using a cross-sectional design with survey sampling techniques, we conducted descriptive analyses for prevalence of CAM use by gender...
November 25, 2016: Headache
https://www.readbyqxmd.com/read/27876685/efficacy-of-mobile-serious-games-in-increasing-hiv-risk-perception-in-swaziland-a-randomized-control-trial-sgprev-trial-research-protocol
#9
Bhekumusa Wellington Lukhele, Patou Musumari, Christina El-Saaidi, Teeranee Techasrivichien, S Pilar Suguimoto, Masako Ono Kihara, Masahiro Kihara
BACKGROUND: The human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) continue to be a major public health problem in Sub-Saharan Africa (SSA), particularly in Swaziland, which has the highest HIV prevalence in this region. A wide range of strategies and interventions have been used to promote behavior change, though almost all such interventions have involved mass media. Therefore, innovative behavior change strategies beyond mass media communication are urgently needed...
November 22, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27876084/a-trial-to-determine-whether-septic-shock-reversal-is-quicker-in-pediatric-patients-randomized-to-an-early-goal-directed-fluid-sparing-strategy-versus-usual-care-squeeze-study-protocol-for-a-pilot-randomized-controlled-trial
#10
Melissa J Parker, Lehana Thabane, Alison Fox-Robichaud, Patricia Liaw, Karen Choong
BACKGROUND: Current pediatric septic shock resuscitation guidelines from the American College of Critical Care Medicine focus on the early and goal-directed administration of intravascular fluid followed by vasoactive medication infusions for persistent and fluid-refractory shock. However, accumulating adult and pediatric data suggest that excessive fluid administration is associated with worse patient outcomes and even increased risk of death. The optimal amount of intravascular fluid required in early pediatric septic shock resuscitation prior to the initiation of vasoactive support remains unanswered...
November 22, 2016: Trials
https://www.readbyqxmd.com/read/27870694/does-intrasession-concurrent-strength-and-aerobic-training-order-influence-training-induced-explosive-strength-and-v-combining-dot-above-o2max-in-prepubescent-children
#11
Ana R Alves, Carlos C Marta, Henrique P Neiva, Mikel Izquierdo, Mário C Marques
Alves, AR, Marta, C, Neiva, HP, Izquierdo, M, and Marques, MC. Does intrasession concurrent strength and aerobic training order influence training-induced explosive strength and V[Combining Dot Above]O2max in prepubescent children?. J Strength Cond Res 30(12): 3267-3277, 2016-The aim of this study was to analyze the interference of strength and aerobic training order over an 8-week period on explosive skills and maximal oxygen uptake (V[Combining Dot Above]O2max) in prepubescent children. One hundred twenty-eight prepubescent children aged 10-11 years (10...
December 0: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27870322/information-literacy-advocates-developing-student-skills-through-a-peer-support-approach
#12
Ruth Curtis
Since 2013/2014, an Information Literacy Advocates (ILA) scheme has been running at the University of Nottingham as an extracurricular module on the Nottingham Advantage Award programme. The Information Literacy Advocates scheme, which recruits medicine and health sciences students in their second year or above, aims to facilitate development of information literacy skills and confidence, as well as communication, organisation and teamwork, through the provision of peer support. Previous research indicates peer assistance effectively enhances such skills and is valued by fellow students who welcome the opportunity to approach more experienced students for help...
December 2016: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/27864253/macquarie-surgical-innovation-identification-tool-msiit-a-study-protocol-for-a-usability-and-pilot-test
#13
Brette Blakely, Amanda Selwood, Wendy A Rogers, Robyn Clay-Williams
INTRODUCTION: Medicine relies on innovation to continually improve. However, innovation is potentially risky, and not all innovations are successful. Therefore, it is important to identify innovations prospectively and provide support, to make innovation as safe and effective as possible. The Macquarie Surgical Innovation Identification Tool (MSIIT) is a simple checklist designed as a practical tool for hospitals to identify planned surgical innovations. This project aims to test the usability and pilot the use of the MSIIT in a surgical setting...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27864203/implementation-of-a-multidisciplinary-pharmacogenomics-clinic-in-a-community-health-system
#14
Henry M Dunnenberger, Matthew Biszewski, Gillian C Bell, Annette Sereika, Holley May, Samuel G Johnson, Peter J Hulick, Janardan Khandekar
PURPOSE: The development and implementation of a multidisciplinary pharmacogenomics clinic within the framework of an established community-based medical genetics program are described. SUMMARY: Pharmacogenomics is an important component of precision medicine that holds considerable promise for pharmacotherapy optimization. As part of the development of a health system-wide integrated pharmacogenomics program, in early 2015 Northshore University Health-System established a pharmacogenomics clinic run by a multidisciplinary team including a medical geneticist, a pharmacist, a nurse practitioner, and genetic counselors...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27860475/-new-diagnostic-imaging-technique-shear-wave-elastography
#15
M Zemanová
Shear wave elastography (SWE) is a new non-invasive diagnostic imaging technique, that maps the elastic properties of tissues. Nowadays this modality develops increasingly in medicine across its disciplines and opens a new era of high-quality ultrasound examination because it increases the specificity and thus improves diagnostic assurance. This method is similar to manual palpation, shows elastic properties of biological tissues and provides a kind of reconstruction of the internal structure of soft tissues based on measurement of the response of tissue compression...
2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/27846471/the-impact-of-training-informal-health-care-providers-in-india-a-randomized-controlled-trial
#16
Jishnu Das, Abhijit Chowdhury, Reshmaan Hussam, Abhijit V Banerjee
Health care providers without formal medical qualifications provide more than 70% of all primary care in rural India. Training these informal providers may be one way to improve the quality of care where few alternatives exist. We report on a randomized controlled trial assessing a program that provided 72 sessions of training over 9 months to 152 informal providers (out of 304). Using standardized patients ("mystery clients"), we assessed clinical practice for three different conditions to which both providers and trainers were blinded during the intervention, representative of the range of conditions that these providers normally diagnose and treat...
October 7, 2016: Science
https://www.readbyqxmd.com/read/27816544/low-health-literacy-flashcards-mobile-video-reinforcement-to-improve-medication-adherence-in-patients-on-oral-diabetes-heart-failure-and-hypertension-medications
#17
Denise L Yeung, Kristin S Alvarez, Marissa E Quinones, Christopher A Clark, George H Oliver, Carlos A Alvarez, Adeola O Jaiyeola
OBJECTIVE: To design and investigate a pharmacist-run intervention using low health literacy flashcards and a smartphone-activated quick response (QR) barcoded educational flashcard video to increase medication adherence and disease state understanding. DESIGN: Prospective, matched, quasi-experimental design. SETTING: County health system in Dallas, Texas. PARTICIPANTS: Sixty-eight primary care patients prescribed targeted heart failure, hypertension, and diabetes medications INTERVENTION: Low health literacy medication and disease specific flashcards, which were also available as QR-coded online videos, were designed for the intervention patients...
November 2, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27806673/sprint-performance-and-mechanical-outputs-computed-with-an-iphone-app-comparison-with-existing-reference-methods
#18
Natalia Romero-Franco, Pedro Jiménez-Reyes, Adrián Castaño-Zambudio, Fernando Capelo-Ramírez, Juan José Rodríguez-Juan, Jorge González-Hernández, Francisco Javier Toscano-Bendala, Víctor Cuadrado-Peñafiel, Carlos Balsalobre-Fernández
The purpose of this study was to assess validity and reliability of sprint performance outcomes measured with an iPhone application (named: MySprint) and existing field methods (i.e. timing photocells and radar gun). To do this, 12 highly trained male sprinters performed 6 maximal 40-m sprints during a single session which were simultaneously timed using 7 pairs of timing photocells, a radar gun and a newly developed iPhone app based on high-speed video recording. Several split times as well as mechanical outputs computed from the model proposed by Samozino et al...
November 3, 2016: European Journal of Sport Science
https://www.readbyqxmd.com/read/27802918/high-throughput-assay-for-quantification-of-the-plasma-concentrations-of-thiopental-using-automated-solid-phase-extraction-spe-directly-coupled-to-lc-ms-ms-instrumentation
#19
Seyed Mojtaba Moosavi, Kiran Shekar, John Fraser, Maree T Smith, Sussan Ghassabian
Most previous assays for thiopental are time-consuming due to laborious sample extraction steps prior to analysis using gas chromatography or high pressure liquid chromatography. Here, we describe the first high-throughput liquid chromatography - tandem mass spectrometry (LC-MS/MS) method for quantification of thiopental concentrations in samples of human plasma. Robotic on-line solid phase extraction (SPE) was used to elute the analytes of interest from samples of human plasma (50μL) loaded onto C18 SPE cartridges to which were added aliquots (50μL) of internal standard solution (thiopental-d5 100ng/mL) and 0...
October 27, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27802024/faster-algorithms-for-isomer-network-generation
#20
Dheivya Thiagarajan, Dinesh P Mehta
Isomer networks provide a mechanism to understand and interpret relationships between organic molecules with applications in medicinal chemistry and drug design. The extraction of isomer networks is a time and data-intensive computation (e.g., we have experimentally determined the space required for the computation of a set of 25 isomers of Nicotine to be 205 MB. Extrapolating this, we have projected the computation to require 8 TB of storage for a set of 1,050,219 isomers of nicotine). In this paper we describe our efforts to improve the network extraction process by using the symmetry present in most molecules to reduce runtime and memory and streamlining the algorithm used for the detection of duplicate dnNames...
November 1, 2016: Journal of Chemical Information and Modeling
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