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https://www.readbyqxmd.com/read/29772188/hamstring-and-ankle-flexibility-deficits-are-weak-risk-factors-for-hamstring-injury-in-professional-soccer-players-a-prospective-cohort-study-of-438-players-including-78-injuries
#1
Nicol van Dyk, Abdulaziz Farooq, Roald Bahr, Erik Witvrouw
BACKGROUND: Hamstring injuries remain a significant injury burden in sports such as soccer that involve high-speed running. It has repeatedly been identified as the most common noncontact injury in elite male soccer, representing 12% of all injuries. As the incidence of hamstring injuries remains high, investigations are aimed at better understanding how to prevent hamstring injuries. Stretching to improve flexibility is commonly used in elite-level sports, but risk factor studies have reported contradicting results, leading to unclear conclusions regarding flexibility as a risk factor for hamstring injuries...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29765261/depression-in-medical-students-current-insights
#2
REVIEW
Fiona Moir, Jill Yielder, Jasmine Sanson, Yan Chen
Medical students are exposed to multiple factors during their academic and clinical study that have been shown to contribute to high levels of depression, anxiety, and stress. The purpose of this article was to explore the issue of depression in the medical student population, including prevalence, causes, and key issues, along with suggestions for early identification and support from one medical school in New Zealand. After establishing that the prevalence of depression is higher for medical students than the general population, the key issues explored include assessment used in the program, characteristics of the student population (such as Type A personality and perfectionism), resilience, selection procedures, students' motivation, and the nature of the clinical environment...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29755558/antiparasitic-activity-and-essential-oil-chemical-analysis-of-the-piper-tuberculatum-jacq-fruit
#3
Valterlúcio Dos Santos Sales, Álefe Brito Monteiro, Gyllyandeson de Araújo Delmondes, Emmily Petícia do Nascimento, Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo, Cristina Kelly de Souza Rodrigues, Josefa Fernanda Evangelista de Lacerda, Cícera Norma Fernandes, Maysa de Oliveira Barbosa, Adamo Xenofonte Brasil, Saulo Relison Tintino, Maria Celeste Vega Gomez, Cathia Coronel, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf
With the increase of neglected diseases such as leishmaniasis and Chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. Thus, this study was performed to investigate the antiparasitic activity of the essential oil from the fruits of Piper tuberculatum Jacq, against lines of Leishmania braziliensis (MHOM/CO/88/UA301), Leishmania infantum (MHOM/ES/92/BCN83) and Trypanosoma cruzi (LC-B5 clone). Before running protocols, an analysis of the chemical composition of essential oil was conducted, which presented monoterpenes and sesquiterpenes...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29753299/homeopathic-prevention-and-management-of-epidemic-diseases
#4
Jennifer Jacobs
BACKGROUND:  Homeopathy has been used to treat epidemic diseases since the time of Hahnemann, who used Belladonna to treat scarlet fever. Since then, several approaches using homeopathy for epidemic diseases have been proposed, including individualization, combination remedies, genus epidemicus, and isopathy. METHODS:  The homeopathic research literature was searched to find examples of each of these approaches and to evaluate which were effective. RESULTS:  There is good experimental evidence for each of these approaches...
May 12, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29750922/legal-aspects-of-sleep-medicine-in-the-21-st-century
#5
REVIEW
Saiprakash B Venkateshiah, Romy Hoque, Nancy A Collop
Multiple manifestations of sleep disorders may interact with the law making it important to increase awareness of such interactions among clinicians. Patients with excessive sleepiness may have civil (and in some states criminal) liability if they fall asleep while driving and cause a motor vehicle accident. Employers may be held vicariously liable due to the actions of sleepy employees. Hence awareness of causes of excessive sleepiness such as sleep deprivation and OSA is increasing among trucking, railroad, and other safety sensitive occupations...
May 8, 2018: Chest
https://www.readbyqxmd.com/read/29746359/evaluation-of-a-focused-cardiac-ultrasound-protocol-in-a-pediatric-emergency-department
#6
Antonio Riera, Bevin Weeks, Beth L Emerson, Lei Chen
OBJECTIVES: The objective of this study was to evaluate the implementation of a focused cardiac ultrasound (FoCUS) protocol in a pediatric emergency department (PED). METHODS: We conducted a cross-sectional, observational, quality improvement project in a PED of an urban tertiary care children's hospital. A FoCUS protocol was collaboratively developed by pediatric cardiology and pediatric emergency medicine. This included a reference document with definitions, indications, image acquisition guidelines, and interpretation expectations...
May 9, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29745662/eucommia-ulmoides-oliver-a-potential-feedstock-for-bioactive-products
#7
Ming-Qiang Zhu, Run-Cang Sun
Eucommia ulmoides Oliver (EUO), a traditional Chinese herb, contains a variety of bioactive chemicals including lignans, iridoids, phenolics, steroids, terpenoids, flavonoids, etc. These bioactive chemicals possess the effective function in nourishing liver and kidney and regulating blood pressure. The composition of bioactive chemicals extracted from EUO vary to the different functional parts (leaves, seeds, bark and staminate flower) and planting models. The bioactive parts of EUO are widely utilized as raw materials for medicine and food, powdery extracts, herbal foumulations and tinctured extracts...
May 10, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29744235/strategic-combination-of-isocratic-and-gradient-elution-for-simultaneous-separation-of-polar-compounds-in-traditional-chinese-medicines-by-hplc
#8
Mei-Tuo Zhang, Xiao-Xue Ye, Wei Lan, Yan-Ling Yang, Tsunghsueh Wu, Yu-Sang Li, He-Bin Tang
A simple high-performance liquid chromatography (HPLC) method for the simultaneous separation of the highly polar and weakly polar components of traditional Chinese medicines was developed via a strategic combination of isocratic and gradient elution methods. Liu-Shen-Wan and Liu-Wei-Di-Huang-Wan were used as representative examples of traditional Chinese medicines. This is the first time that 6 components of varying degrees of polarity in Liu-Shen-Wan had been successfully resolved in a single chromatographic run using an ultraviolet-visible detector with a fixed wavelength of 296 nm...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29740521/satisfaction-with-healthcare-received-at-an-interprofessional-student-run-free-clinic-invested-in-training-the-next-generation-of-healthcare-professionals
#9
Karen B Lu, Bryan Thiel, Christopher A Atkins, Anand Desai, Ariel Botwin, Michael R Povlow, Judith Simms-Cendan, Magdalena Pasarica
Most medical schools in the United States have an associated student-run free clinic (SRFC) providing medical care to the underserved population around the campus. SRFCs provide students with opportunities to practice history-taking and diagnosis skills. There have been a few studies that have evaluated patient satisfaction within SRFCs; however, these studies report limited aspects of care within these clinics. This study hopes to determine the levels of satisfaction with clinical staff and operations and to ensure that the medical needs of patients are being met...
March 7, 2018: Curēus
https://www.readbyqxmd.com/read/29738168/-umbilicus-application-of-huobi-powder-for-ed-with-kidney-deficiency-dampness-a-randomized-controlled-clinical-trial
#10
Run-Biao Dong, Guang-Sen Li, De-Gui Chang, Jian Cai, Qu An
Objective: To prove the clinical efficacy of umbilicus application of Huobi Powder for the treatment of erectile dysfunction (ED) with the traditional Chinese medicine (TCM) syndrome of kidney deficiency dampness by related clinical indexes. METHODS: This randomized controlled double-blind clinical study included 72 ED patients with the TCM syndrome of kidney deficiency dampness treated by 12-hour application of Huobi Powder (the trial group, n = 36) or placebo (the control group, n = 36) to the umbilicus qd for 28 consecutive days...
November 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29736398/educational-software-applied-in-teaching-electrocardiogram-a-systematic-review
#11
REVIEW
Paulo A I Pontes, Rafael O Chaves, Roberto C Castro, Érica F de Souza, Marcos C R Seruffo, Carlos R L Francês
Background: The electrocardiogram (ECG) is the most used diagnostic tool in medicine; in this sense, it is essential that medical undergraduates learn how to interpret it correctly while they are still on training. Naturally, they go through classic learning (e.g., lectures and speeches). However, they are not often efficiently trained in analyzing ECG results. In this regard, methodologies such as other educational support tools in medical practice, such as educational software, should be considered a valuable approach for medical training purposes...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29735394/dorzagliatin-monotherapy-in-chinese-patients-with-type-2-diabetes-a-dose-ranging-randomised-double-blind-placebo-controlled-phase-2-study
#12
Dalong Zhu, Shenglian Gan, Yu Liu, Jianhua Ma, Xiaolin Dong, Weihong Song, Jiao'e Zeng, Guixia Wang, Wenjuan Zhao, Qiu Zhang, Yukun Li, Hui Fang, Xiaofeng Lv, Yongquan Shi, Haoming Tian, Linong Ji, Xin Gao, Lihui Zhang, Yuqian Bao, Minxiang Lei, Ling Li, Longyi Zeng, Xiaoying Li, Xinghua Hou, Yu Zhao, Tianxin Hu, Xiaoyun Ge, Guiyu Zhao, Yongguo Li, Yi Zhang, Li Chen
BACKGROUND: Glucokinase acts as a glucose sensor in the pancreas and a glucose processor in the liver, and has a central role in glucose homoeostasis. Dorzagliatin is a new, dual-acting, allosteric glucokinase activator that targets both pancreatic and hepatic glucokinases. Dorzagliatin has good pharmacokinetic and pharmacodynamic properties in humans, and provides effective 24-h glycaemic control and improves glucose sensitivity in patients with type 2 diabetes. We aimed to assess the efficacy and safety of dorzagliatin monotherapy at different doses in Chinese patients with type 2 diabetes...
May 4, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#13
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29725956/use-of-prophylactic-saccharomyces-boulardii-to-prevent-clostridium-difficile-infection-in-hospitalized-patients-a-controlled-prospective-intervention-study
#14
Jeppe West Carstensen, Mahtab Chehri, Kristian Schønning, Steen Christian Rasmussen, Jacob Anhøj, Nina Skavlan Godtfredsen, Christian Østergaard Andersen, Andreas Munk Petersen
Clostridium difficile infection (CDI) is a common complication to antibiotic use. Saccharomyces boulardii has shown effect as a prophylactic agent. We aimed to evaluate the efficacy of S. boulardii in preventing CDI in unselected hospitalized patients treated with antibiotics. We conducted a 1 year controlled prospective intervention study aiming to prescribe Sacchaflor (S. boulardii 5 × 109 , Pharmaforce ApS) twice daily to hospitalized patients treated with antibiotics. Comparable departments from three other hospitals in our region were included as controls...
May 3, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29718579/a-simulation-approach-for-power-calculation-in-large-cohort-studies-based-on-multistate-models
#15
Bastian Jenny, Jan Beyersmann, Martin Schumacher
Realistic power calculations for large cohort studies and nested case control studies are essential for successfully answering important and complex research questions in epidemiology and clinical medicine. For this, we provide a methodical framework for general realistic power calculations via simulations that we put into practice by means of an R-based template. We consider staggered recruitment and individual hazard rates, competing risks, interaction effects, and the misclassification of covariates. The study cohort is assembled with respect to given age-, gender-, and community distributions...
May 2, 2018: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/29718389/an-update-on-pug-rest-restful-interface-for-programmatic-access-to-pubchem
#16
Sunghwan Kim, Paul A Thiessen, Tiejun Cheng, Bo Yu, Evan E Bolton
PubChem (https://pubchem.ncbi.nlm.nih.gov) is one of the largest open chemical information resources available. It currently receives millions of unique users per month on average, serving as a key resource for many research fields such as cheminformatics, chemical biology, medicinal chemistry, and drug discovery. PubChem provides multiple programmatic access routes to its data and services. One of them is PUG-REST, a Representational State Transfer (REST)-like web service interface to PubChem. On average, PUG-REST receives more than a million requests per day from tens of thousands of unique users...
April 30, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29717714/multi-position-data-collection-and-dynamic-beam-sizing-recent-improvements-to-the-automatic-data-collection-algorithms-on-massif-1
#17
Olof Svensson, Maciej Gilski, Didier Nurizzo, Matthew W Bowler
Macromolecular crystallography is now a mature and widely used technique that is essential in the understanding of biology and medicine. Increases in computing power combined with robotics have not only enabled large numbers of samples to be screened and characterized but have also enabled better decisions to be taken on data collection itself. This led to the development of MASSIF-1 at the ESRF, the first beamline in the world to run fully automatically while making intelligent decisions taking user requirements into account...
May 1, 2018: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29714573/a-pilot-experiment-in-responding-to-individual-patient-requests-for-compassionate-use-of-an-unapproved-drug-the-compassionate-use-advisory-committee-compac
#18
Arthur Caplan, Alison Bateman-House, Joanne Waldstreicher, Lisa Fedor, Ramana Sonty, Tito Roccia, Jon Ukropec, Rick Jansson
BACKGROUND: Janssen Research & Development, LLC, part of the Janssen pharmaceutical companies of Johnson & Johnson, and NYU School of Medicine partnered to establish the Compassionate Use Advisory Committee (CompAC) to evaluate the use of an independent, external, expert committee in ensuring transparent, fair, beneficent, evidence-based, and patient-focused compassionate access to investigational medicines, a public health challenge that has been an ongoing issue for over 3 decades...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29706894/high-performance-agent-based-modeling-applied-to-vocal-fold-inflammation-and-repair
#19
Nuttiiya Seekhao, Caroline Shung, Joseph JaJa, Luc Mongeau, Nicole Y K Li-Jessen
Fast and accurate computational biology models offer the prospect of accelerating the development of personalized medicine. A tool capable of estimating treatment success can help prevent unnecessary and costly treatments and potential harmful side effects. A novel high-performance Agent-Based Model (ABM) was adopted to simulate and visualize multi-scale complex biological processes arising in vocal fold inflammation and repair. The computational scheme was designed to organize the 3D ABM sub-tasks to fully utilize the resources available on current heterogeneous platforms consisting of multi-core CPUs and many-core GPUs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29704060/breast-cancer-patients-satisfaction-with-individual-therapy-goals-and-treatment-in-a-standardized-integrative-medicine-consultancy-service
#20
Carolin C Hack, Sophia Antoniadis, Janina Hackl, Hanna Langemann, Judith Schwitulla, Peter A Fasching, Matthias W Beckmann, Anna-Katharin Theuser
PURPOSE: Complementary medicine services are nowadays usually quite heterogeneous, and little information is available on standards for running an integrative medicine consultancy service. This study aimed to assess patients' satisfaction with a standardized treatment service on integrative medicine. METHODS: Using a cross-sectional design, 75 breast cancer patients from the integrative medicine consultancy service at the University Breast Center for Franconia were evaluated between January 2016 and March 2017...
April 27, 2018: Archives of Gynecology and Obstetrics
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