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https://www.readbyqxmd.com/read/29349812/drug-promotion-practices-a-review
#1
Nilan T Jacob
Over the years, the pharmaceutical industry has been at the forefront of research and innovation in drug discovery and development. The process of drug discovery extending from pre-clinical studies to multi-centric clinical trials and post-marketing phase is a costly affair running into billions of dollars. On the flip side, not all investigational molecules clear the trial phases and get approved; which puts pressure on the manufacturers to maximise the profit from approved drugs. It is in this key area, the practice of drug promotion plays its role...
January 18, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29346701/identifying-prevalence-and-characteristics-of-behavioral-health-education-in-family-medicine-clerkships-a-cera-study
#2
Mario P DeMarco, Renée M Betancourt, Kelly M Everard, Kent D W Bream
BACKGROUND AND OBJECTIVES: Many patients with behavioral health disorders do not seek or receive adequate care for their conditions. Among those that do, most will receive care in a primary care setting. To best meet this need, clinicians will need to demonstrate proficiency of behavioral health skills and evidence-based practices. We sought to explore the degree to which these skills are being taught in family medicine clerkships. METHODS: The Council of Academic Family Medicine's (CAFM) Educational Research Alliance (CERA) 2016 survey of clerkship directors (CDs) was sent to 141 CDs at US and Canadian medical schools with a required family medicine run course...
January 2018: Family Medicine
https://www.readbyqxmd.com/read/29338240/biki-life-sciences-a-new-suite-for-molecular-dynamics-and-related-methods-in-drug-discovery
#3
Sergio Decherchi, Giovanni Bottegoni, Andrea Spitaleri, Walter Rocchia, Andrea Cavalli
In this paper, we introduce the BiKi Life Sciences suite. This software makes it easy for computational medicinal chemists to run ad hoc molecular dynamics protocols in a novel and task-oriented environment; as a notebook, BiKi keeps memory of any activity together with dependencies among them. It offers unique accelerated protein-ligand binding/unbinding methods, and other useful tools to gain actionable knowledge from MD simulations and to simplify the drug discovery process.
January 17, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29337562/physiologically-based-pharmacokinetic-modeling-in-lead-optimization-ii-rational-bioavailability-design-by-global-sensitivity-analysis-to-identify-properties-affecting-bioavailability
#4
Pankaj R Daga, Michael B Bolger, Ian Haworth, Robert Daniel Clark, Eric J Martin
When medicinal chemists need to improve oral bioavailability (%F) during lead optimization, they systematically modify compound properties mainly based on their own experience and general rules of thumb. However, at least a dozen properties can influence %F, and the difficulty of multi-parameter optimization for such complex non-linear processes grows combinatorially with the number of variables. Furthermore, strategies can be in conflict. For example, adding a polar or charged group will generally increase solubility but decrease permeability...
January 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29335822/emergency-department-throughput-an-intervention
#5
Nowreen Haq, Rona Stewart-Corral, Eric Hamrock, Jamie Perin, Waseem Khaliq
Shortening emergency department (ED) boarding time and managing hospital bed capacity by expediting the inpatient discharge process have been challenging for hospitals nationwide. The objective of this study is was to explore the effect of an innovative prospective intervention on hospital workflow, specifically on early inpatient discharges and the ED boarding time. The intervention consisted of a structured nursing "admission discharge transfer" (ADT) protocol receiving new admissions from the ED and helping out floor nursing with early discharges...
January 15, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29331859/development-of-a-method-to-determine-axitinib-lapatinib-and-afatinib-in-plasma-by-micellar-liquid-chromatography-and-validation-by-the-european-medicines-agency-guidelines
#6
Jaume Albiol-Chiva, Josep Esteve-Romero, Juan Peris-Vicente
A method based on micellar liquid chromatography to quantify the tyrosine kinase inhibitors axitinib, lapatinib and afatinib in plasma is reported. The sample pretreatment was a simple 1/5-dilution in a pure micellar solution, filtration and direct injection, without requiring extraction or purification steps. The three drugs were resolved from the matrix in 17min, using an aqueous solution of 0.07M sodium dodecyl sulfate - 6.0% 1-pentanol, buffered at pH7 with 0.01M phosphate salt as mobile phase, running under isocratic mode at 1mL/min through a C18 column...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29327122/understanding-qi-running-in-the-meridians-as-interstitial-fluid-flowing-via-interstitial-space-of-low-hydraulic-resistance
#7
Wei-Bo Zhang, De-Xian Jia, Hong-Yan Li, Yu-Long Wei, Huang Yan, Peng-Na Zhao, Fei-Fei Gu, Guang-Jun Wang, Yan-Ping Wang
Qi, blood and the meridians are fundamental concepts in Chinese medicine (CM), which are components of the human body and maintain physiological function. Pathological changes of qi, blood and meridians may lead to discomfort and disease. Treatment with acupuncture or herbal medicine aims to regulate qi and blood so as to recover normal function of the meridians. This paper explores the nature of qi as well as compares and correlates them with the structures of the human body. We propose a conceptualization of qi as being similar to the interstitial flfl uid, and the meridians as being similar to interstitial space of low hydraulic resistance in the body...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29325605/establishment-of-detection-antibodies-brrs-batch-4-for-in-vitro-potency-assay-of%C3%A2-hepatitis-a-vaccines-by-elisa
#8
S Morgeaux, A Koy, I Manniam, E Regourd, P Variot, A Costanzo
The European Pharmacopoeia (Ph. Eur.) standard ELISA method for determination of antigen content of hepatitis A vaccines (HAV) requires specific coating and detection Biological Reference Reagents (BRRs). The 3rd batch of detection antibodies BRRs was established in 2015 for use in conjunction with the Ph. Eur. general chapter 2.7.14 'Assay of hepatitis A vaccine'. Stocks of these BRRs were running low and therefore the European Directorate for the Quality of Medicines & HealthCare (EDQM) organised a collaborative study to qualify replacement batches...
2018: Pharmeuropa Bio & Scientific Notes
https://www.readbyqxmd.com/read/29322848/inpatient-satisfaction-at-different-public-sector-hospitals-of-a-metropolitan-city-in-pakistan-a-comparative-cross-sectional-study
#9
Mehwish Hussain, Rehana Rehman, Zia Ikramuddin, Nava Asad, Ayesha Farooq
OBJECTIVE: To observe inpatient satisfaction at different public sector hospitals of Karachi, Pakistan. METHODS: A cross sectional study was carried out during 2010-2012 in four major public sector hospitals of Karachi. A total of 710 patients completed the study. Responses were gathered in a self-structured questionnaire that comprised of four dimensions of satisfaction with doctor, staff, administration and treatment. Average Score of each dimension was taken and compared using one way analysis of variance...
January 11, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29320925/self-perceived-and-actual-motor-competence-in-young-british-children
#10
Michael J Duncan, Victoria Jones, Wesley O'Brien, Lisa M Barnett, Emma L J Eyre
Children's perception of their own motor competence is an important correlate of their actual motor competence. The current study is the first to examine this association in British children and the first to use both product and process measures of actual motor competence. A total of 258 children (139 boys and 119 girls; aged 4 to 7 years, Mean = 5.6, SD = .96) completed measures of self-perceived motor competence using the Pictorial Scale for Perceived Movement Competence in Young Children. Children were classified as "Low," "Medium," or "High" perceived competence based on tertile analysis...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29319285/when-traditional-chinese-medicine-runs-on-whatsapp%C3%A2
#11
Monica Corazza, Giulia Toni, Annarosa Virgili, Alessandro Borghi
No abstract text is available yet for this article.
February 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29306971/trauma-care-in-german-speaking-countries-have-changes-in-the-curricula-led-to-changes-in-practice-after-10%C3%A2-years
#12
Sarah Kuhn-Régnier, Michael Stickel, Björn-Christian Link, Henning Fischer, Reto Babst, Frank J P Beeres
PURPOSE: Traditionally, in the German-speaking countries, trauma patients are treated by general surgeons specialized in trauma surgery known as the Unfallchirurg. Over the last decade, a trend towards a lower influence of surgeons and a higher influence of subspecialties in the emergency department has been noted. With additional transformations in the health care system towards highly specialized medicine and the arising of new (sub-) specialties, diversification in the management of the trauma patient appears to occur...
January 6, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29305045/integrative-medicine-or-infiltrative-pseudoscience
#13
Ben Li, Thomas L Forbes, John Byrne
Evidence-based medicine, first described in 1992, offers a clear, systematic, and scientific approach to the practice of medicine. Recently, the non-evidence-based practice of complementary and alternative medicine (CAM) has been increasing in the United States and around the world, particularly at medical institutions known for providing rigorous evidence-based care. The use of CAM may cause harm to patients through interactions with evidence-based medications or if patients choose to forego evidence-based care...
January 2, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29303043/-the-best-laid-schemes-o-mice-an-men-a-workshop-to-teach-the-application-of-evidence-based-medicine-in-low-and-middle-income-countries
#14
Rakesh Narendra Modi, Laura Chapman, Camille Gajria, Eugene Yee Hing Tang
Background Evidence-Based Medicine (EBM) is often an ideal, with beginnings in positivist science. More recent relativism, rights and ethics have challenged a binary view of EBM. Medical volunteering is a paradigm as GPs and trainees often run EBM projects in low- and middle-income countries (LMICs), which require significant contextual adaptation. We created a workshop to enable GPs and GP trainees to reflect on and plan for the factors important in the application of EBM in LMICs. We describe the first running at the 21st WONCA Europe Conference...
January 5, 2018: Education for Primary Care
https://www.readbyqxmd.com/read/29298301/mapping-of-global-scientific-research-in-comorbidity-and-multimorbidity-a-cross-sectional-analysis
#15
Ferrán Catalá-López, Adolfo Alonso-Arroyo, Matthew J Page, Brian Hutton, Rafael Tabarés-Seisdedos, Rafael Aleixandre-Benavent
BACKGROUND: The management of comorbidity and multimorbidity poses major challenges to health services around the world. Analysis of scientific research in comorbidity and multimorbidity is limited in the biomedical literature. This study aimed to map global scientific research in comorbidity and multimorbidity to understand the maturity and growth of the area during the past decades. METHODS AND FINDINGS: This was a cross-sectional analysis of the Web of Science...
2018: PloS One
https://www.readbyqxmd.com/read/29294701/elevated-risky-sexual-behaviors-among-sexual-minority-girls-indirect-risk-pathways-through-peer-victimization-and-heavy-drinking
#16
Sarah S Dermody, Mark Friedman, Deena J Chisolm, Chad M Burton, Michael P Marshal
Sexual minority girls (SMGs), compared with heterosexual females, are more likely to report negative sexual outcomes including earlier age of sexual intercourse debut, more lifetime and recent sexual partners, pregnancy involvement, and sex while intoxicated. Data describing the mechanisms related to these health disparities are limited. The purpose of this study was therefore to longitudinally assess the roles of sexual minority-related peer victimization and heavy episodic drinking (HED) as mediators of the relation between sexual minority status and sexual outcomes...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29287263/simultaneous-quantification-of-fluoxetine-and-norfluoxetine-in-colostrum-and-mature-human-milk-using-a-2-dimensional-liquid-chromatography-tandem-mass-spectrometry-system
#17
Bianca Rebelo Lopes, Neila Maria Cassiano, Daniela Miarelli Carvalho, Elaine Christine Dantas Moisés, Quezia Bezerra Cass
A two-dimensional liquid chromatography system coupled to triple quadrupole tandem mass spectrometer (2D LC-MS/MS) was employed for the determination of fluoxetine (FLU) and norfluoxetine (N-FLU) in colostrum and mature milk by direct sample injection. With a run time of 12 min representing a gain in throughput analysis, the validated methods furnished selectivity, extraction efficiency, accuracy, and precision in accordance with the criteria preconized by the European Medicines Agency guidelines. With a linear range of 3...
December 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29286534/fitness-training-for-cardiorespiratory-conditioning-after-traumatic-brain-injury
#18
REVIEW
Leanne Hassett, Anne M Moseley, Alison R Harmer
BACKGROUND: Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. OBJECTIVES: The primary objective of this updated review was to evaluate whether fitness training improves cardiorespiratory fitness in people who have sustained a TBI. The secondary objectives were to evaluate whether fitness training improves body function and structure (physical and cognitive impairments, psychological responses resulting from the injury), activity limitations and participation restrictions in people who have sustained a TBI as well as to evaluate its safety, acceptance, feasibility and suitability...
December 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29281931/mutagenicity-anticancer-activity-and-blood-brain-barrier-similarity-and-dissimilarity-of-molecular-alerts
#19
Andrey A Toropov, Alla P Toropova, Emilio Benfenati, Mario Salmona
The aim of the present work is an attempt to define computable measure of similarity between different endpoints. The similarity of structural alerts of different biochemical endpoints can be used to solve tasks of medicinal chemistry. Optimal descriptors are a tool to build up models for different endpoints. The optimal descriptor is calculated with simplified molecular input-line entry system (SMILES). A group of elements (single symbol or pair of symbols) can represent any SMILES. Each element of SMILES can be represented by so-called correlation weight i...
December 27, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29273671/how-is-defensive-medicine-understood-and-experienced-in-a-primary-care-setting-a-qualitative-focus-group-study-among-danish-general-practitioners
#20
Elisabeth Assing Hvidt, Jesper Lykkegaard, Line Bjørnskov Pedersen, Kjeld Møller Pedersen, Anders Munck, Merethe Kousgaard Andersen
OBJECTIVES: Recent years have witnessed a progressive increase in defensive medicine (DM) in several Western welfare countries. In Danish primary and secondary care, documentation on the extent of DM is lacking. Before investigating the extent of DM, we wanted to explore how the phenomenon is understood and experienced in the context of general practice in Denmark. The objective of the study was to describe the phenomenon of DM as understood and experienced by Danish general practitioners (GPs)...
December 21, 2017: BMJ Open
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