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Matej Podbregar, Ana Ursula Gavric, Eva Podbregar, Hugon Mozina, Sebastian Stefanovic
BACKGROUND: Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. PATIENTS AND METHODS: Twenty-four chronic anaemic haematology patients were included...
December 1, 2016: Radiology and Oncology
Nassim Nasseri, Stefan Kleiser, Daniel Ostojic, Tanja Karen, Martin Wolf
Change of muscle tissue oxygen saturation (StO2), due to exercise, measured by near infrared spectroscopy (NIRS) is known to be lower for subjects with higher adipose tissue thickness. This is most likely not physiological but caused by the superficial fat and adipose tissue. In this paper we assessed, in vitro, the influence of adipose tissue thickness on muscle StO2, measured by NIRS oximeters. We measured StO2 of a liquid phantom by 3 continuous wave (CW) oximeters (Sensmart Model X-100 Universal Oximetry System, INVOS 5100C, and OxyPrem v1...
November 1, 2016: Biomedical Optics Express
Kevin Steenhaut, Koen Lapage, Thierry Bové, Stefan De Hert, Annelies Moerman
An increasing number of NIRS devices are used to provide measurements of peripheral tissue oxygen saturation (StO2). The aim of the present study is to test the hypothesis that despite technological differences between devices, similar trend values will be obtained during a vascular occlusion test. The devices compared are NIRO-200NX, which measures StO2 and oxyhemoglobin by spatially resolved spectroscopy and the Beer-Lambert law, respectively, and INVOS 5100C and Foresight Elite, which both measure StO2 with the Beer-Lambert law, enhanced with the spatial resolution technique...
November 22, 2016: Journal of Clinical Monitoring and Computing
Kaitlin M McLay, Federico Y Fontana, Josh P Nederveen, Donald H Paterson, Silvia Pogliaghi, Juan M Murias
We thank Tremblay and King for their interest in our publication (McLay et al., 2016a), which has since been followed up with studies by McLay et al. (McLay et al., 2016c, 2016b). In these studies, it is suggested that the near-infrared spectroscopy (NIRS)-derived measure of tissue oxygen saturation (StO2 ), specifically the reperfusion rate (Slope 2) following a brief period of ischemia, can be easily applied as a reliable, non-invasive measure of vascular reactivity (McLay et al., 2016a, 2016c, 2016b)...
November 11, 2016: Experimental Physiology
Rogério B Corvino, Harry B Rossiter, Thiago Loch, Jéssica C Martins, Fabrizio Caputo
PURPOSE: We aimed to identify a blood flow restriction (BFR) endurance exercise protocol that would both maximize cardiopulmonary and metabolic strain, and minimize the perception of effort. METHODS: Twelve healthy males (23 ± 2 years, 75 ± 7 kg) performed five different exercise protocols in randomized order: HI, high-intensity exercise starting at 105% of the incremental peak power (P peak); I-BFR30, intermittent BFR at 30% P peak; C-BFR30, continuous BFR at 30% P peak; CON30, control exercise without BFR at 30% P peak; I-BFR0, intermittent BFR during unloaded exercise...
November 8, 2016: European Journal of Applied Physiology
S Suzuki, E E Castrillon, T Arima, Y Kitagawa, P Svensson
Myofascial pain associated with temporomandibular disorders has often been linked to pathological muscle hyperactivity. As a result, localised disturbances of intramuscular blood flow could lead to a lower level of oxygen distribution, hypoxia and microcirculatory changes. To assess haemodynamic changes in the masseter muscle during sustained elevated muscle activity (SEMA). Sixteen healthy participants performed thirty 1-min bouts of SEMA with intervals of 1-min 'rest' periods between the bouts on a bite force transducer device...
December 2016: Journal of Oral Rehabilitation
Abele Donati, Elisa Damiani, Roberta Domizi, Claudia Scorcella, Andrea Carsetti, Stefania Tondi, Valentina Monaldi, Erica Adrario, Rocco Romano, Paolo Pelaia, Mervyn Singer
BACKGROUND: Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared spectroscopy (NIRS) with a vascular occlusion test (VOT). METHODS: Prospective observational study in critically ill adults admitted to a 12-bed intensive care unit (ICU) of a University Hospital...
October 1, 2016: Critical Care: the Official Journal of the Critical Care Forum
Samuel Valable, Aurélien Corroyer-Dulmont, Ararat Chakhoyan, Lucile Durand, Jérôme Toutain, Didier Divoux, Louisa Barré, Eric T MacKenzie, Edwige Petit, Myriam Bernaudin, Omar Touzani, Emmanuel L Barbier
The partial pressure in oxygen remains challenging to map in the brain. Two main strategies exist to obtain surrogate measures of tissue oxygenation: the tissue saturation studied by magnetic resonance imaging (StO2-MRI) and the identification of hypoxia by a positron emission tomography (PET) biomarker with 3-[(18)F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([(18)F]-FMISO) as the leading radiopharmaceutical. Nonetheless, a formal validation of StO2-MRI against FMISO-PET has not been performed. The objective of our studies was to compare the two approaches in (a) the normal rat brain when the rats were submitted to hypoxemia; (b) animals implanted with four tumour types differentiated by their oxygenation...
October 4, 2016: Journal of Cerebral Blood Flow and Metabolism
Justin J Skowno, Jonathan S Karpelowsky, Nicola R Watts, David G Little
BACKGROUND: Vascular complications following pediatric liver transplantation occur in 8-10% of cases, and no continuous, non-invasive monitoring for this problem exists. Near infrared spectroscopy (NIRS) allows non-invasive, continuous, transcutaneous assessment of hemoglobin oxygenation (StO2 ) 1-4 cm below the skin surface. AIMS: We hypothesized that transcutaneous NIRS would be able to detect severe hepatic ischemia, and tested this in an animal model using 15-20 kg and 5-7 kg juvenile pigs...
December 2016: Paediatric Anaesthesia
Tarik Delko, Henry Hoffmann, Marko Kraljevic, Raoul A Droeser, Lincoln Rothwell, Daniel Oertli, Urs Zingg
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has become a very popular surgical treatment for the treatment of morbidly obese patients. Staple line leaks are the major cause of severe morbidity. Reasons for leaks might be hyperpressure (mechanical theory) or hypoperfusion (vascular theory) of the narrow gastric tube. This study assessed microperfusion patterns of the stomach during LSG using visible light spectroscopy (VLS), a method to measure tissue oxygenation (saturated O2 (StO2))...
September 19, 2016: Obesity Surgery
R P E Boezeman, B P Becx, D A F van den Heuvel, Ç Ünlü, J A Vos, J P P M de Vries
OBJECTIVE: Near-infrared spectroscopy (NIRS) non-invasively determines tissue oxygen saturation (Sto2) in muscle tissue. Its application to monitor real time hemodynamic changes during percutaneous transluminal angioplasty (PTA) and Sto2 changes in feet 4 weeks after PTA was evaluated. METHODS: This study included 14 patients with critical limb ischemia (CLI, six patients Rutherford classification Stage IV, two patients Stage V, and six patients Stage VI). In patients with arterial ulcers, NIRS optodes were placed near the ulcer of the diseased foot (Optode 1), and at the same spot at the contralateral foot (Optode 2)...
September 7, 2016: European Journal of Vascular and Endovascular Surgery
Jonathon Bryce Olenczak, Daniel Murariu, Keita Ikeda, Robert H Thiele, Chris A Campbell
Background Flap monitoring with near-infrared spectroscopy (NIRS) facilitates early detection of vascular compromise. However, standard NIRS devices that employ two wavelengths of light to assess tissue oxygenation (StO2) are susceptible to artifact from background noise and demonstrate significant variability in the clinical setting. As the number of wavelengths detected by a NIRS device is increased, the precision of StO2 measurements can be improved and additional chromophores other than oxyhemoglobin and deoxyhemoglobin can be measured...
August 19, 2016: Journal of Reconstructive Microsurgery
Zhihai Qiu, Guangping Yao, Defu Chen, Ying Wang, Ying Gu, Buhong Li
Characterizing port wine stains (PWS) with its optical parameters [i.e. absorption coefficient (μ a) and reduced scattering coefficient (μ s')] and microvascular parameters [i.e. blood volume fraction (BVF), mean vessel diameter (MVD), and oxygen saturation (StO2)] is extremely important for elucidating the mechanisms for its light-based treatments, such as pulsed dye laser and photodynamic therapy. In this study, a customized diffuse reflectance spectroscopy (DRS) probe with an appropriate source-detector distance was used to measure the diffuse reflectance spectra of PWS lesions in clinical practice...
2016: Advances in Experimental Medicine and Biology
Yasuhisa Kaneko, Ryotaro Kime, Eiji Furuya, Ayumi Sakamoto, Toshihito Katsumura
Muscle tissue oxygenation is a critical issue in muscle complications such as pain, exhaustion, stiffness, or fatigue during and after exercise. The aim of this study was to investigate whether the changes of muscle tissue oxygenation could be observed at both erector spinae muscle at S1 level and gastrocnemius during and after acupuncture stimulation to ipsilateral erector spinae at S1 level. The subjects were ten healthy males. Muscle oxygenation was monitored by near infrared spectroscopy (NIRS), and the probes were placed on the right side of the erector spinae muscle at S1 level (Guanyuanshu, BL26) and the belly of the gastrocnemius on the right (Chengjin, BL56)...
2016: Advances in Experimental Medicine and Biology
Shiho Yamabata, Hirokazu Shiraishi, Mai Munechika, Hideki Fukushima, Yoshiyuki Fukuoka, Tatsuya Hojo, Takeshi Shirayama, Motoyuki Horii, Satoaki Matoba, Toshikazu Kubo
OBJECTIVES: We investigated the effects of electrical stimulation therapy on cutaneous and muscle blood flow in critical limb ischemia patients following regenerative therapy. METHODS: Three groups were studied: 10 healthy young subjects, 10 elderly subjects, and 7 critical limb ischemia patients after regenerative therapy. After 5 min rest, electrical stimulation was applied at 5 Hz on the tibialis anterior muscle for 10 min. We estimated the relative changes in oxyhemoglobin and total hemoglobin compared to the basal values at rest (Δ[HbO2], Δ[Hbtot]), which reflected the blood flow in the skin and muscle layer, and we simultaneously measured the tissue O2 saturation (StO2) throughout the electrical stimulation and recovery phase by near-infrared spectroscopy...
2016: SAGE Open Medicine
Ligia Simões Braga Boisserand, Benjamin Lemasson, Lydiane Hirschler, Anaïck Moisan, Violaine Hubert, Emmanuel L Barbier, Chantal Rémy, Olivier Detante
Recent advances in MRI methodology, such as microvascular and brain oxygenation (StO2) imaging, may prove useful in obtaining information about the severity of the acute stroke. We assessed the potential of StO2 to detect the ischaemic core in the acute phase compared to apparent diffusion coefficient and to predict the final necrosis. Sprague-Dawley rats (n = 38) were imaged during acute stroke (D0) and 21 days after (D21). A multiparametric MRI protocol was performed at 4.7T to characterize brain damage within three region of interest: 'LesionD0' (diffusion), 'Mismatch' representing penumbra (perfusion/diffusion) and 'Hypoxia' (voxels < 40% of StO2 within the region of interest LesionD0)...
July 27, 2016: Journal of Cerebral Blood Flow and Metabolism
Kaitlin M McLay, James E Gilbertson, Silvia Pogliaghi, Donald H Paterson, Juan M Murias
The reperfusion rate of near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2 ) represent vascular responsiveness. This study examined if the reperfusion slope of StO2 is sensitive to different ischemic conditions (i.e., a dose-response) and if differences exist between two groups of different fitness levels. Nine healthy trained (T; Age: 25 ± 3 yr; VO2max : 63.4 ± 6.7 ml kg(-1)  min(-1) ) and nine healthy untrained (UT; Age: 21 ± 1 yr; VO2max : 46.6 ± 2.5 ml kg(-1)  min(-1) ) men performed a series of vascular occlusion tests of different durations (30 s, 1 min, 2 min, 3 min, and 5 min), each separated by 30 min...
July 18, 2016: Experimental Physiology
Jarich W Spliethoff, Lisanne L de Boer, Mark A J Meier, Warner Prevoo, Jeroen de Jong, Torre M Bydlon, Henricus J C M Sterenborg, Jacobus A Burgers, Benno H W Hendriks, Theodoor J M Ruers
OBJECTIVES: Difficulties in obtaining a representative tissue sample are a major obstacle in timely selecting the optimal treatment for patients with lung cancer or other malignancies. Having a modality to provide needle guidance and confirm the biopsy site selection could be of great clinical benefit, especially when small masses are targeted. The objective of this study was to evaluate whether diffuse reflectance spectroscopy (DRS) at the tip of a core biopsy needle can be used for biopsy site confirmation in real time, thereby enabling optimized biopsy acquisition and improving diagnostic capability...
August 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
J Kolbenschlag, A Sogorski, N Kapalschinski, K Harati, M Lehnhardt, A Daigeler, T Hirsch, O Goertz
BACKGROUND: Surgical flaps have become safe and reliable tools in the reconstructive armamentarium. However, total flap loss rates of up to 25% and partial flap loss rates up to 36% are reported in the literature, most often due to insufficient perfusion and the resulting hypoxia. Therefore, a reliable, non-invasive and effective way to improve the microcirculation of surgical flaps is desirable. Remote Ischemic Conditioning (RIC) is the repeated application of non-damaging cycles of ischemia and reperfusion on an organ remote to the tissue to be conditioned...
July 5, 2016: Plastic and Reconstructive Surgery
O Shannon, M Barlow, L Duckworth, D R Woods, T Barker, A Grindrod, A Griffiths, J P O'Hara
The purpose of this study was to assess the reliability of a pre-loaded 1 500-m treadmill time trial, conducted in moderate normobaric hypoxia. 8 trained runners/triathletes (24±3 years, 73.2±8.1 kg, 182.5±6.5 cm, altitude specific V˙O2max: 52.9±5.5 ml·kg(-1)·min(-1)) completed 3 trials (the first as a familiarisation), involving 2, 15-min running bouts at 45% and 65% V˙O2max, respectively, and a 1 500-m time trial in moderate normobaric hypoxia equivalent to a simulated altitude of 2 500 m (FiO2~15%)...
September 2016: International Journal of Sports Medicine
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