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https://www.readbyqxmd.com/read/28717916/colon-perfusion-patterns-during-colorectal-resection-using-visible-light-spectroscopy
#1
Henry Hoffmann, Tarik Delko, Philipp Kirchhoff, Rachel Rosenthal, Juliane Schäfer, Marko Kraljević, Christoph Kettelhack
BACKGROUND: The impact of blood supply to the anastomosis on development of anastomotic leakage is still a matter of debate. Considering that bowel perfusion may be affected by manipulation during surgery, perfusion assessment of the anastomosis alone may be of limited value. We propose perfusion assessment at different time points during surgery to explore the dynamics of bowel perfusion during colorectal resection and its impact on outcome. METHODS: In this prospective cohort study, patients undergoing elective colorectal resection were eligible...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28715342/quantitative-evaluation-of-rehabilitation-effect-on-peripheral-circulation-of-diabetic-foot
#2
Yao-Kuang Huang, Chang-Cheng Chang, Pin-Xing Lin, Bor-Shyh Lin
Diabetics may encounter different foot problems, which easily lead to infection, ulcers, and increased risk of amputation due to nerve or vascular injury. In order to reduce the risk of amputation, Buerger's exercise is one of the frequently used rehabilitation to improve the blood circulation in the lower limbs. However, it is difficult to evaluate the rehabilitation efficiency of Buerger's exercise objectively. In this study, a novel non-invasively optical system was developed to non-invasively monitor the change of the foot blood circulation before and after long-term Buerger's exercise...
July 13, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28702902/oxygenation-status-in-chronic-leg-ulcer-after-topical-hemoglobin-application-may-act-as-a-surrogate-marker-to-find-the-best-treatment-strategy-and-to-avoid-ineffective-conservative-long-term-therapy
#3
Maximilian Petri, Ingo Stoffels, Klaus Griewank, Jithin Jose, Peter Engels, Andrea Schulz, Harald Pötzschke, Philipp Jansen, Dirk Schadendorf, Joachim Dissemond, Joachim Klode
PURPOSE: Chronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained increased attention as a relevant factor in wound healing. To increase oxygenation in wounds, a topical hemoglobin spray was developed. Although favorable results have been noted, the link between clinical efficacy and the mode of action has not been demonstrated...
July 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28693932/muscle-tissue-saturation-compared-with-muscle-tissue-perfusion-during-low-blood-flows-an-experimental-study
#4
Sisse Anette Thomassen, Benedict Kjærgaard, Aage Kristian Olsen Alstrup, Ole Lajord Munk, Jørgen Frøkiær, Anders Larsson, Bodil Steen Rasmussen
OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model. DESIGN: A prospective, randomized study. SETTING: Research laboratory, single institution. PARTICIPANTS: Eight pigs (69-71 kg)...
March 22, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28685457/physiological-effects-of-continuous-colored-light-exposure-on-mayer-wave-activity-in-cerebral-hemodynamics-a-functional-near-infrared-spectroscopy-fnirs-study
#5
A J Metz, S D Klein, F Scholkmann, U Wolf
We are increasingly exposed to colored light, but its impact on human physiology is not yet extensively investigated. In the present study we aimed to determine the effects of colored light on human cerebral Mayer wave activity (MWA). We measured oxy- ([O2Hb]), deoxy- ([HHb]), total hemoglobin ([tHb]) concentrations and tissue oxygen saturation (StO2) by functional near-infrared spectroscopy (fNIRS) in the left and right pre-frontal cortex (L-PFC, R-PFC) of 17 subjects (median age: 29 years, 6 women). In a randomized crossover design subjects were exposed to blue, red, green, and yellow LED light for 10 min...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685454/delayed-onset-of-reoxygenation-in-inactive-muscles-after-high-intensity-exercise
#6
Takuya Osawa, Keisuke Shiose, Hideyuki Takahashi
Oxygenation, measured by near-infrared spectroscopy (NIRS), in inactive muscles decreases during high-intensity exercise because of the decrease of oxygen supply. However, there have been few reports regarding recovery of inactive muscle oxygenation after exercise. This study was performed to examine reoxygenation in the biceps brachii muscle (BB) after supramaximal cycling exercise. Six active young male volunteers (age: 22  ±  3 years, peak oxygen uptake (VO2peak): 53.8  ±  5.4 mL/kg/min, mean  ±  S...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28685423/dorsiflexor-muscle-oxygenation-during-low-moderate-and-submaximal-sustained-isometric-contraction
#7
Adkham Paiziev, Martin Wolf, Fikrat Kerimov
Sustained isometric contractions of skeletal muscles produce intramuscular pressures that lead to blood flow restriction. Thus, we have the paradox of rising O2 demand due to muscle activity and at the same time reduced blood flow. The aim was to assess muscle oxygenation during sustained isometric low (30%), moderate (60%) and submaximal [90% of maximal voluntary contraction (MVC)] contraction of the dorsiflexor muscle. Experiments were conducted on the dominant (right) leg of 8 male students (age 19 ± 2 years, weight 75 ± 6 kg)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28684191/effects-of-oral-sodium-nitrate-on-forearm-blood-flow-oxygenation-and-exercise-performance-during-acute-exposure-to-hypobaric-hypoxia-4300%C3%A2-m
#8
Heath G Gasier, Anthony R Reinhold, Allison R Loiselle, Shawn E Soutiere, David M Fothergill
A reduction in oxygen transport contributes to impaired exercise capacity at high altitude. Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance. In a double-blind, randomized crossover study, 10 healthy subjects (9 males and 1 female) performed continuous (CGrip) and repeated rhythmic (RGrip) isometric forearm exercise until task failure in normobaric normoxia (NN), 2...
July 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28683458/oral-nitrate-increases-microvascular-reactivity-and-the-number-of-visible-perfused-microvessels-in-healthy-volunteers
#9
Louis Kolb, Diego Orbegozo, Jacques Creteur, Jean-Charles Preiser, Jean-Louis Vincent, Daniel De Backer
Nitric oxide (NO) plays an important role in controlling microcirculatory function, but the effects of exogenous administration of nitrate (NO3-) on the microcirculation have not been well studied. We evaluated whether NO3- could influence the microvascular response to hypoxia in 17 healthy volunteers. We used a vascular occlusion test (VOT) to assess the response of near-infrared spectroscopy-derived indexes to hypoxic stress before and 2 h 15 min after oral administration of 800 mg potassium nitrate. We also monitored changes in the sublingual microcirculation using side-stream dark-field (SDF) video microscopy...
July 7, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28666929/fluid-responsiveness-after-cardiac-surgery-fracas-a-prospective-observational-study-using-peripheral-near-infrared-spectroscopy
#10
Ethan Butler, John Nguyen, Sajeev Mahendran, Anders Aneman
OBJECTIVES: To describe tissue oxygen saturation (StO2) in response to a vascular occlusion test using thenar eminence and forearm near-infrared spectroscopy (NIRS) and the association with volume responsiveness after cardiac surgery. DESIGN: Single-center, prospective, observational cohort study. SETTING: Cardiothoracic intensive care unit. PARTICIPANTS: Seventy-six post-cardiac surgical adults. INTERVENTIONS: Immediately before and 10 minutes after a 250-to-500 mL fluid bolus, StO2 was measured in response to a vascular occlusion test to calculate tissue deoxygenation (Rdes) and reoxygenation (Rres) rates...
March 18, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28663381/a-study-of-clinical-and-physiological-relations-of-daily-physical-activity-in-precapillary-pulmonary-hypertension
#11
Marios Panagiotou, Martin Kevin Johnson, Zafeiris Louvaris, Julien Steven Baker, Alistair Colin Church, Andrew J Peacock, Ioannis Vogiatzis
Daily physical activity is reduced in precapillary pulmonary hypertension (PH) but the underlying mechanisms are inadequately explored. We sought to investigate clinical and physiological relations of daily physical activity and profile differences between less and more active patients with precapillary PH. A prospective, cross-sectional study of 20 patients with precapillary PH who undertook a) a comprehensive clinical assessment, b) a preliminary treadmill test, c) 7-day monitoring of daily walking intensity with triaxial accelerometry and d) a personalized treadmill test corresponding to the individual patient mean daily walking intensity with real-time physiological measurements...
June 29, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28585358/muscle-microcirculation-alterations-and-relation-to-dipping-status-in-newly-diagnosed-untreated-patients-with-arterial-hypertension-a-pilot-study
#12
Georgios Tzanis, Stavros Dimopoulos, Chris Manetos, Eleni Koroboki, Efstathios Manios, Ioannis Vasileiadis, Nikolaos Zakopoulos, Serafim Nanas
OBJECTIVE: The importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with Near Infrared Spectroscopy (NIRS), a non-invasive method that evaluates microcirculation. METHODS: We evaluated 34 subjects, 17 patients with AH (13 males, 49±13y, BMI: 26±2 kg/m(2) ) and 17 healthy controls (12 males, 49±15y, BMI: 25±3 kg/m(2) )...
June 5, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28582335/a-prospective-clinical-trial-comparing-visible-light-spectroscopy-to-handheld-doppler-for-postoperative-free-tissue-transfer-monitoring
#13
Alexander F Mericli, James Wren, Patrick B Garvey, Jun Liu, Charles E Butler, Jesse C Selber
BACKGROUND: Early detection of compromised free flap perfusion is critical. A common modality of thrombosis detection, physical exam augmented with hand-held Doppler, only provides intermittent data and is insensitive to venous compromise. Visible light spectroscopy (VLS) provides continuous, non-invasive evaluation of tissue perfusion. We hypothesized that VLS is a more sensitive and specific monitoring method for early detection of post-operative flap compromise than intermittent, hand-held Doppler and clinical exam...
June 1, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28553990/investigating-the-effects-of-cerebrospinal-fluid-removal-on-cerebral-blood-flow-and-oxidative-metabolism-in-infants-with-post-hemorrhagic-ventricular-dilatation
#14
Peter J McLachlan, Jessica Kishimoto, Mamadou Diop, Daniel Milej, David S C Lee, Sandrine de Ribaupierre, Keith St Lawrence
BackgroundPost-hemorrhagic ventricular dilatation (PHVD) is predictive of mortality and morbidity among very-low-birth-weight preterm infants. Impaired cerebral blood flow (CBF) due to elevated intracranial pressure (ICP) is believed to be a contributing factor.MethodsA hyperspectral near-infrared spectroscopy (NIRS) method of measuring CBF and the cerebral metabolic rate of oxygen (CMRO2) was used to investigate perfusion and metabolism changes in patients receiving a ventricular tap (VT) based on clinical management...
June 14, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28514777/direct-measurement-of-tissue-oxygenation-in-neonates-via-resonance-raman-spectroscopy-a-pilot-study
#15
Anjali Iyengar, Andrew Gaillardetz, Hocine Tighiouart, Betsabee Castillo, Padraic Romfh, Jonathan M Davis
BACKGROUND: The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures. Resonance Raman spectroscopy noninvasively measures tissue oxygenation (RRS-StO2). Peripheral tissue oxygenation using this novel technology has not been described in neonates. OBJECTIVES: To examine the relationship between short-term RRS-StO2 measurements and central venous saturation (ScvO2) and pulse oximetry (SpO2) in preterm and term neonates...
May 18, 2017: Neonatology
https://www.readbyqxmd.com/read/28455779/microvascular-reactivity-measured-by-vascular-occlusion-test-is-an-independent-predictor-for-postoperative-bleeding-in-patients-undergoing-cardiac-surgery
#16
Karam Nam, Hyung-Min Oh, Chang-Hoon Koo, Tae Kyong Kim, Youn Joung Cho, Deok Man Hong, Yunseok Jeon
The purpose of the study is to investigate the relationship between microvascular reactivity and postoperative bleeding in cardiac surgery. The authors retrospectively analyzed a prospectively collected registry of cardiac surgery patients. Data from 154 patients enrolled in the registry were analyzed. A linear mixed model was performed to evaluate the association between the amount of postoperative chest tube output (CTO, milliliter, repeatedly measured at 0-8, 8-24, and 24-48 h) and tissue oxygen saturation (StO2) recovery slope (%/s) measured by vascular occlusion test (VOT) at skin closure...
April 28, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28374103/a-validation-method-for-near-infrared-spectroscopy-based-tissue-oximeters-for-cerebral-and-somatic-tissue-oxygen-saturation-measurements
#17
Paul B Benni, David MacLeod, Keita Ikeda, Hung-Mo Lin
We describe the validation methodology for the NIRS based FORE-SIGHT ELITE(®) (CAS Medical Systems, Inc., Branford, CT, USA) tissue oximeter for cerebral and somatic tissue oxygen saturation (StO2) measurements for adult subjects submitted to the United States Food and Drug Administration (FDA) to obtain clearance for clinical use. This validation methodology evolved from a history of NIRS validations in the literature and FDA recommended use of Deming regression and bootstrapping statistical validation methods...
April 3, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28360433/use-of-near-infrared-spectroscopy-nirs-in-cerebral-tissue-oxygenation-monitoring-in-neonates
#18
Rene Gumulak, Lucia Casnocha Lucanova, Mirko Zibolen
Near-infrared spectroscopy (NIRS) is a technology capable of non-invasive, continuous measuring of regional tissue oxygen saturation (StO2). StO2 represents a state of hemodynamic stability, which is influenced by many factors. Extensive research has been done in the field of measuring StO2 of various organs. The current clinical availability of several NIRS-based devices reflects an important development in prevention, detection and correction of discrepancy in oxygen delivery to the brain and vital organs...
March 30, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28343815/soft-tissue-oxygen-saturation-to-predict-admission-from-the-emergency-department-a-prospective-observational-study
#19
William T Davis, Josh Lospinso, Robert M Barnwell, John Hughes, Steven G Schauer, Thomas B Smith, Michael D April
OBJECTIVE: We evaluated a soft tissue oxygen saturation (Sto2) measurement at triage for predicting admission to the hospital in adults presenting to the emergency department (ED) in addition to data routinely gathered at triage. METHODS: This was a prospective, observational, single center study of adults presenting to the ED for evaluation. Research assistants obtained thenar eminence Sto2 measurements on subjects in ED triage. ED providers not involved in the study then made all management and disposition decisions...
March 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28340289/remote-ischaemic-conditioning-decreases-blood-flow-and-improves-oxygen-extraction-in-patients-with-early-complex-regional-pain-syndrome
#20
T Hegelmaier, N Kumowski, T Mainka, J Vollert, O Goertz, M Lehnhardt, P K Zahn, C Maier, J Kolbenschlag
BACKGROUND: Remote ischaemic conditioning (RIC) is the cyclic application of non-damaging ischaemia leading to an increased tissue perfusion, among others triggered by NO (monoxide). Complex regional pain syndrome (CRPS) is known to have vascular alterations such as increased blood shunting and decreased NO blood-levels, which in turn lead to decreased tissue perfusion. We therefore hypothesized that RIC could improve tissue perfusion in CRPS. METHOD: In this proof-of-concept study, RIC was applied in the following groups: in 21 patients with early CRPS with a clinical history less than a year, in 20 age/sex-matched controls and in 12 patients with unilateral nerve lesions via a tourniquet on the unaffected/non-dominant upper limb...
March 24, 2017: European Journal of Pain: EJP
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