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https://www.readbyqxmd.com/read/28585358/muscle-microcirculation-alterations-and-relation-to-dipping-status-in-newly-diagnosed-untreated-patients-with-arterial-hypertension-a-pilot-study
#1
Georgios Tzanis, Stavros Dimopoulos, Chris Manetos, Eleni Koroboki, Efstathios Manios, Ioannis Vasileiadis, Nikolaos Zakopoulos, Serafim Nanas
OBJECTIVE: The importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with Near Infrared Spectroscopy (NIRS), a non-invasive method that evaluates microcirculation. METHODS: We evaluated 34 subjects, 17 patients with AH (13 males, 49±13y, BMI: 26±2 kg/m(2) ) and 17 healthy controls (12 males, 49±15y, BMI: 25±3 kg/m(2) )...
June 5, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28582335/a-prospective-clinical-trial-comparing-visible-light-spectroscopy-to-handheld-doppler-for-postoperative-free-tissue-transfer-monitoring
#2
Alexander F Mericli, James Wren, Patrick B Garvey, Jun Liu, Charles E Butler, Jesse C Selber
BACKGROUND: Early detection of compromised free flap perfusion is critical. A common modality of thrombosis detection, physical exam augmented with hand-held Doppler, only provides intermittent data and is insensitive to venous compromise. Visible light spectroscopy (VLS) provides continuous, non-invasive evaluation of tissue perfusion. We hypothesized that VLS is a more sensitive and specific monitoring method for early detection of post-operative flap compromise than intermittent, hand-held Doppler and clinical exam...
June 1, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28553990/investigating-the-effects-of-cerebrospinal-fluid-removal-on-cerebral-blood-flow-and-oxidative-metabolism-in-infants-with-post-hemorrhagic-ventricular-dilatation
#3
Peter J McLachlan, Jessica Kishimoto, Mamadou Diop, Daniel Milej, David S C Lee, Sandrine de Ribaupierre, Keith St Lawrence
BackgroundPost-hemorrhagic ventricular dilatation (PHVD) is predictive of mortality and morbidity among very-low-birth-weight preterm infants. Impaired cerebral blood flow (CBF) due to elevated intracranial pressure (ICP) is believed to be a contributing factor.MethodsA hyperspectral near-infrared spectroscopy (NIRS) method of measuring CBF and the cerebral metabolic rate of oxygen (CMRO2) was used to investigate perfusion and metabolism changes in patients receiving a ventricular tap (VT) based on clinical management...
June 14, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28514777/direct-measurement-of-tissue-oxygenation-in-neonates-via-resonance-raman-spectroscopy-a-pilot-study
#4
Anjali Iyengar, Andrew Gaillardetz, Hocine Tighiouart, Betsabee Castillo, Padraic Romfh, Jonathan M Davis
BACKGROUND: The ability to monitor tissue oxygenation in neonates remains a challenge due to limited blood supply and the reliance on invasive procedures. Resonance Raman spectroscopy noninvasively measures tissue oxygenation (RRS-StO2). Peripheral tissue oxygenation using this novel technology has not been described in neonates. OBJECTIVES: To examine the relationship between short-term RRS-StO2 measurements and central venous saturation (ScvO2) and pulse oximetry (SpO2) in preterm and term neonates...
May 18, 2017: Neonatology
https://www.readbyqxmd.com/read/28455779/microvascular-reactivity-measured-by-vascular-occlusion-test-is-an-independent-predictor-for-postoperative-bleeding-in-patients-undergoing-cardiac-surgery
#5
Karam Nam, Hyung-Min Oh, Chang-Hoon Koo, Tae Kyong Kim, Youn Joung Cho, Deok Man Hong, Yunseok Jeon
The purpose of the study is to investigate the relationship between microvascular reactivity and postoperative bleeding in cardiac surgery. The authors retrospectively analyzed a prospectively collected registry of cardiac surgery patients. Data from 154 patients enrolled in the registry were analyzed. A linear mixed model was performed to evaluate the association between the amount of postoperative chest tube output (CTO, milliliter, repeatedly measured at 0-8, 8-24, and 24-48 h) and tissue oxygen saturation (StO2) recovery slope (%/s) measured by vascular occlusion test (VOT) at skin closure...
April 28, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28374103/a-validation-method-for-near-infrared-spectroscopy-based-tissue-oximeters-for-cerebral-and-somatic-tissue-oxygen-saturation-measurements
#6
Paul B Benni, David MacLeod, Keita Ikeda, Hung-Mo Lin
We describe the validation methodology for the NIRS based FORE-SIGHT ELITE(®) (CAS Medical Systems, Inc., Branford, CT, USA) tissue oximeter for cerebral and somatic tissue oxygen saturation (StO2) measurements for adult subjects submitted to the United States Food and Drug Administration (FDA) to obtain clearance for clinical use. This validation methodology evolved from a history of NIRS validations in the literature and FDA recommended use of Deming regression and bootstrapping statistical validation methods...
April 3, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28360433/use-of-near-infrared-spectroscopy-nirs-in-cerebral-tissue-oxygenation-monitoring-in-neonates
#7
Rene Gumulak, Lucia Casnocha Lucanova, Mirko Zibolen
Near-infrared spectroscopy (NIRS) is a technology capable of non-invasive, continuous measuring of regional tissue oxygen saturation (StO2). StO2 represents a state of hemodynamic stability, which is influenced by many factors. Extensive research has been done in the field of measuring StO2 of various organs. The current clinical availability of several NIRS-based devices reflects an important development in prevention, detection and correction of discrepancy in oxygen delivery to the brain and vital organs...
March 30, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28343815/soft-tissue-oxygen-saturation-to-predict-admission-from-the-emergency-department-a-prospective-observational-study
#8
William T Davis, Josh Lospinso, Robert M Barnwell, John Hughes, Steven G Schauer, Thomas B Smith, Michael D April
OBJECTIVE: We evaluated a soft tissue oxygen saturation (Sto2) measurement at triage for predicting admission to the hospital in adults presenting to the emergency department (ED) in addition to data routinely gathered at triage. METHODS: This was a prospective, observational, single center study of adults presenting to the ED for evaluation. Research assistants obtained thenar eminence Sto2 measurements on subjects in ED triage. ED providers not involved in the study then made all management and disposition decisions...
March 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28340289/remote-ischaemic-conditioning-decreases-blood-flow-and-improves-oxygen-extraction-in-patients-with-early-complex-regional-pain-syndrome
#9
T Hegelmaier, N Kumowski, T Mainka, J Vollert, O Goertz, M Lehnhardt, P K Zahn, C Maier, J Kolbenschlag
BACKGROUND: Remote ischaemic conditioning (RIC) is the cyclic application of non-damaging ischaemia leading to an increased tissue perfusion, among others triggered by NO (monoxide). Complex regional pain syndrome (CRPS) is known to have vascular alterations such as increased blood shunting and decreased NO blood-levels, which in turn lead to decreased tissue perfusion. We therefore hypothesized that RIC could improve tissue perfusion in CRPS. METHOD: In this proof-of-concept study, RIC was applied in the following groups: in 21 patients with early CRPS with a clinical history less than a year, in 20 age/sex-matched controls and in 12 patients with unilateral nerve lesions via a tourniquet on the unaffected/non-dominant upper limb...
March 24, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28327077/regional-muscle-tissue-saturation-is-an-indicator-of-global-inadequate-circulation-during-cardiopulmonary-bypass-a-randomized-porcine-study-using-muscle-intestinal-and-brain-tissue-metabolomics
#10
Sisse Anette Thomassen, Benedict Kjærgaard, Preben Sørensen, Jan Jesper Andreasen, Anders Larsson, Bodil Steen Rasmussen
BACKGROUND: Muscle tissue saturation (StO2) measured with near-infrared spectroscopy has generally been considered a measurement of the tissue microcirculatory condition. However, we hypothesized that StO2 could be more regarded as a fast and reliable measure of global than of regional circulatory adequacy and tested this with muscle, intestinal and brain metabolomics at normal and two levels of low cardiopulmonary bypass blood flow rates in a porcine model. METHODS: Twelve 80 kg pigs were connected to normothermic cardiopulmonary bypass with a blood flow of 60 mL/kg/min for one hour, reduced randomly to 47...
April 2017: Perfusion
https://www.readbyqxmd.com/read/28270997/in-vivo-imaging-of-hepatic-hemodynamics-and-light-scattering-property-during-ischemia-reperfusion-in-rats-based-on-spectrocolorimetry
#11
Sharmin Akter, Satoko Kawauchi, Shunichi Sato, Suefumi Aosasa, Junji Yamamoto, Izumi Nishidate
A red-green-blue camera-based imaging method is proposed for estimating spatial maps of concentrations of oxyhemoglobin (CHbO), deoxyhemoglobin (CHbR), total hemoglobin (CHbT), tissue oxygen saturation (StO2), and scattering power (b) in liver tissue. Hemodynamic responses to hepatic ischemia-reperfusion of in vivo rat liver tissues induced by portal triad occlusion were evaluated. Upon portal triad occlusion, this method yielded images of decreased CHbO, CHbT, StO2, and b, and increased CHbR followed by a progressive increase in CHbO and StO2 during reperfusion...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28206993/hemodynamic-effects-of-sodium-bicarbonate-administration
#12
A C Katheria, M K Brown, K Hassan, D M Poeltler, D A Patel, V K Brown, J B Sauberan
OBJECTIVE: To describe the hemodynamic changes that occur with sodium bicarbonate (NaHCO3) administration in premature neonates. STUDY DESIGN: This retrospective study included premature neonates 23 to 31+6 weeks of gestational age who underwent continuous cardiac and cerebral monitoring as participants in prospective trials at our institution, and who received NaHCO3 infused over 30 min in the first 24 h of life. Blood pressure (BP), heart rate, cardiac output (CO), SpO2 and cerebral oximetry (StO2) were captured every 2 s...
February 16, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28151429/the-influence-of-adipose-tissue-on-spatially-resolved-near-infrared-spectroscopy-derived-skeletal-muscle-oxygenation-the-extent-of-the-problem
#13
Victor M Niemeijer, Jasper P Jansen, Thomas van Dijk, Ruud F Spee, Eduard J Meijer, Hareld M C Kemps, Pieter F F Wijn
OBJECTIVE: Near-infrared spectroscopy (NIRS) measurements of tissue oxygen saturation (StO2) are useful for the assessment of skeletal muscle perfusion and function during exercise, however, they are influenced by overlying skin and adipose tissue. This study explored the extent and nature of the influence of adipose tissue thickness (ATT) on StO2. APPROACH: NIR spatially resolved spectroscopy (SRS) derived oxygenation was measured on vastus lateralis in 56 patients with chronic heart failure (CHF) and 20 healthy control (HC) subjects during rest and moderate intensity exercise with simultaneous assessment of oxygen uptake kinetics (τ [Formula: see text])...
February 2, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28093233/changes-in-vascular-responsiveness-during-a-hyperglycemia-challenge-measured-by-near-infrared-spectroscopy-vascular-occlusion-test
#14
Rogério Nogueira Soares, Raylene A Reimer, Juan Manuel Murias
BACKGROUND: Postprandial hyperglycemia is associated with impaired vascular responsiveness. Recent studies have established the use of a near-infrared spectroscopy (NIRS)-derived approach, combined with a vascular occlusion test (VOT), to examine vascular responsiveness within the microvasculature in normoglycemia. The aim of this study was to examine whether this NIRS-VOT technique could detect differences in vascular responsiveness following a hyperglycemic challenge. METHODS AND RESULTS: Fourteen young healthy individuals participated in the study...
May 2017: Microvascular Research
https://www.readbyqxmd.com/read/28027790/the-impact-of-red-blood-cell-storage-duration-on-tissue-oxygenation-in-cardiac-surgery
#15
Christopher P Stowell, Glenn Whitman, Suzanne Granger, Hernando Gomez, Susan F Assmann, Michael J Massey, Nathan I Shapiro, Marie E Steiner, Elliott Bennett-Guerrero
OBJECTIVE: Although storage alters red blood cells, several recent, randomized trials found no differences in clinical outcomes between patients transfused with red blood cells stored for shorter versus longer periods of time. The objective of this study was to see whether storage impairs the in vivo ability of erythrocytes to traverse the microcirculation and deliver oxygen at the tissue level. METHODS: A subset of subjects from a clinical trial of cardiac surgery patients randomized to receive transfusions of red blood cells stored ≤10 days or ≥21 days were assessed for thenar eminence and cerebral tissue hemoglobin oxygen saturation (StO2) via the use of near-infrared spectroscopy and sublingual microvascular blood flow via side-stream darkfield videomicroscopy...
March 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28008565/broadband-near-infrared-spectroscopy-can-detect-cyanide-induced-cytochrome-aa3-inhibition-in-rats-a-proof-of-concept-study
#16
Robert H Thiele, Keita Ikeda, Yunzhen Wang, Raquel R Bartz, Zhiyi Zuo
PURPOSE: Clinically available near-infrared spectroscopy (NIRS) devices use two to five wavelengths of light to measure the relative amounts of oxyhemoglobin and deoxyhemoglobin in tissue to determine tissue hemoglobin oxygen saturation (StO2). In addition to StO2, broadband NIRS devices (using hundreds of wavelengths of light) may be able to measure the oxidation state of mitochondrial cytochrome aa3 (Cytox) which reflects the subcellular energetic state. We hypothesize that broadband NIRS devices can measure Cytox independent of changes in hemoglobin saturation...
April 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/27986837/greater-v%C3%AB-o2peak-is-correlated-with-greater-skeletal-muscle-deoxygenation-amplitude-and-hemoglobin-concentration-within-individual-muscles-during-ramp-incremental-cycle-exercise
#17
Dai Okushima, David C Poole, Thomas J Barstow, Harry B Rossiter, Narihiko Kondo, T Scott Bowen, Tatsuro Amano, Shunsaku Koga
It is axiomatic that greater aerobic fitness (V˙O2peak) derives from enhanced perfusive and diffusive O2 conductances across active muscles. However, it remains unknown how these conductances might be reflected by regional differences in fractional O2 extraction (i.e., deoxy [Hb+Mb] and tissue O2 saturation [StO2]) and diffusive O2 potential (i.e., total[Hb+Mb]) among muscles spatially heterogeneous in blood flow, fiber type, and recruitment (vastus lateralis, VL; rectus femoris, RF). Using quantitative time-resolved near-infrared spectroscopy during ramp cycling in 24 young participants (V˙O2peak range: ~37...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/27983541/effect-of-increasing-mean-arterial-blood-pressure-on-microcirculation-in-patients-with-cardiogenic-shock-supported-by-extracorporeal-membrane-oxygenation
#18
Zhongtao Du, Zaishen Jia, Jinhong Wang, Zhichen Xing, Chunjing Jiang, Bo Xu, Xiaofang Yang, Feng Yang, Na Miao, Jialin Xing, Hong Wang, Ming Jia, Xiaotong Hou
BACKGROUND: Little is known about the effect of mean arterial blood pressure (MAP) augmentation on the microcirculation in cardiogenic-shock patients with peripheral veno-arterial extracorporeal membrane oxygenation (ECMO) support. We investigated the effect of increasing MAP on the microcirculation in cardiogenic-shock patients with ECMO support. METHODS: A single-center prospective observational study under taken in ICU patients undergoing ECMO support for post-cardiotomy cardiogenic shock was carried out...
December 14, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27932292/graduated-compression-stockings-does-not-decrease-walking-capacity-and-muscle-oxygen-saturation-during-6-minute-walk-test-in-intermittent-claudication-patients
#19
Bruno Remígio Cavalcante, Raphael Mendes Ritti-Dias, Antônio Henrique Germano Soares, Wagner Jorge Ribeiro Domingues, Glauco Fernandes Saes, Flávio Henrique Duarte, Aline de Paula da Cruz, Nelson Wolosker, Pedro Puech-Leão, Gabriel Grizzo Cucato, Antonio Eduardo Zerati
BACKGROUND: We analyze the effects of graduated compression stoking (GCS) on walking capacity and oxygen saturation in intermittent claudication (IC) patients. METHODS: Eighteen patients with IC performed the 6-minute walking test in 2 conditions in random order: GCS or placebo sock. Onset claudication distance and total walking distance were obtained. The calf muscle oxygen saturation was continuously monitored before, during, and after 6-minute walk test. Comparisons of the walking capacity and StO2 parameters between GCS and placebo conditions were analyzed by Wilcoxon rank-sum test...
December 5, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27904454/red-blood-cell-transfusion-and-skeletal-muscle-tissue-oxygenation-in-anaemic-haematologic-outpatients
#20
Matej Podbregar, Ana Ursula Gavric, Eva Podbregar, Hugon Mozina, Sebastian Stefanovic
BACKGROUND: Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. PATIENTS AND METHODS: Twenty-four chronic anaemic haematology patients were included...
December 1, 2016: Radiology and Oncology
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