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Shunichi Suzuki, Eduardo Enrique Castrillon-Watanabe, Taro Arima, Yoshimasa Kitagawa, Peter Svensson
BACKGROUND: Myofascial pain associated with temporomandibular disorders has often been linked to pathological muscle hyperactivity. As a result, localized disturbances of intramuscular blood flow could lead to a lower level of oxygen distribution, hypoxia and microcirculatory changes. AIM: To assess hemodynamic changes in the masseter muscle during sustained elevated muscle activity (SEMA). MATERIALS AND METHODS: Sixteen healthy participants performed thirty 1-minute bouts of SEMA with intervals of 1-minute "rest" periods between the bouts on a bite force transducer device...
October 15, 2016: Journal of Oral Rehabilitation
Abele Donati, Elisa Damiani, Roberta Domizi, Claudia Scorcella, Andrea Carsetti, Stefania Tondi, Valentina Monaldi, Erica Adrario, Rocco Romano, Paolo Pelaia, Mervyn Singer
BACKGROUND: Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared spectroscopy (NIRS) with a vascular occlusion test (VOT). METHODS: Prospective observational study in critically ill adults admitted to a 12-bed intensive care unit (ICU) of a University Hospital...
October 1, 2016: Critical Care: the Official Journal of the Critical Care Forum
Samuel Valable, Aurélien Corroyer-Dulmont, Ararat Chakhoyan, Lucile Durand, Jérôme Toutain, Didier Divoux, Louisa Barré, Eric T MacKenzie, Edwige Petit, Myriam Bernaudin, Omar Touzani, Emmanuel L Barbier
The partial pressure in oxygen remains challenging to map in the brain. Two main strategies exist to obtain surrogate measures of tissue oxygenation: the tissue saturation studied by magnetic resonance imaging (StO2-MRI) and the identification of hypoxia by a positron emission tomography (PET) biomarker with 3-[(18)F]fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([(18)F]-FMISO) as the leading radiopharmaceutical. Nonetheless, a formal validation of StO2-MRI against FMISO-PET has not been performed. The objective of our studies was to compare the two approaches in (a) the normal rat brain when the rats were submitted to hypoxemia; (b) animals implanted with four tumour types differentiated by their oxygenation...
October 4, 2016: Journal of Cerebral Blood Flow and Metabolism
Justin J Skowno, Jonathan S Karpelowsky, Nicola R Watts, David G Little
BACKGROUND: Vascular complications following pediatric liver transplantation occur in 8-10% of cases, and no continuous, non-invasive monitoring for this problem exists. Near infrared spectroscopy (NIRS) allows non-invasive, continuous, transcutaneous assessment of hemoglobin oxygenation (StO2 ) 1-4 cm below the skin surface. AIMS: We hypothesized that transcutaneous NIRS would be able to detect severe hepatic ischemia, and tested this in an animal model using 15-20 kg and 5-7 kg juvenile pigs...
September 24, 2016: Paediatric Anaesthesia
Tarik Delko, Henry Hoffmann, Marko Kraljevic, Raoul A Droeser, Lincoln Rothwell, Daniel Oertli, Urs Zingg
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has become a very popular surgical treatment for the treatment of morbidly obese patients. Staple line leaks are the major cause of severe morbidity. Reasons for leaks might be hyperpressure (mechanical theory) or hypoperfusion (vascular theory) of the narrow gastric tube. This study assessed microperfusion patterns of the stomach during LSG using visible light spectroscopy (VLS), a method to measure tissue oxygenation (saturated O2 (StO2))...
September 19, 2016: Obesity Surgery
R P E Boezeman, B P Becx, D A F van den Heuvel, Ç Ünlü, J A Vos, J P P M de Vries
OBJECTIVE: Near-infrared spectroscopy (NIRS) non-invasively determines tissue oxygen saturation (Sto2) in muscle tissue. Its application to monitor real time hemodynamic changes during percutaneous transluminal angioplasty (PTA) and Sto2 changes in feet 4 weeks after PTA was evaluated. METHODS: This study included 14 patients with critical limb ischemia (CLI, six patients Rutherford classification Stage IV, two patients Stage V, and six patients Stage VI). In patients with arterial ulcers, NIRS optodes were placed near the ulcer of the diseased foot (Optode 1), and at the same spot at the contralateral foot (Optode 2)...
September 7, 2016: European Journal of Vascular and Endovascular Surgery
Jonathon Bryce Olenczak, Daniel Murariu, Keita Ikeda, Robert H Thiele, Chris A Campbell
Background Flap monitoring with near-infrared spectroscopy (NIRS) facilitates early detection of vascular compromise. However, standard NIRS devices that employ two wavelengths of light to assess tissue oxygenation (StO2) are susceptible to artifact from background noise and demonstrate significant variability in the clinical setting. As the number of wavelengths detected by a NIRS device is increased, the precision of StO2 measurements can be improved and additional chromophores other than oxyhemoglobin and deoxyhemoglobin can be measured...
August 19, 2016: Journal of Reconstructive Microsurgery
Zhihai Qiu, Guangping Yao, Defu Chen, Ying Wang, Ying Gu, Buhong Li
Characterizing port wine stains (PWS) with its optical parameters [i.e. absorption coefficient (μ a) and reduced scattering coefficient (μ s')] and microvascular parameters [i.e. blood volume fraction (BVF), mean vessel diameter (MVD), and oxygen saturation (StO2)] is extremely important for elucidating the mechanisms for its light-based treatments, such as pulsed dye laser and photodynamic therapy. In this study, a customized diffuse reflectance spectroscopy (DRS) probe with an appropriate source-detector distance was used to measure the diffuse reflectance spectra of PWS lesions in clinical practice...
2016: Advances in Experimental Medicine and Biology
Yasuhisa Kaneko, Ryotaro Kime, Eiji Furuya, Ayumi Sakamoto, Toshihito Katsumura
Muscle tissue oxygenation is a critical issue in muscle complications such as pain, exhaustion, stiffness, or fatigue during and after exercise. The aim of this study was to investigate whether the changes of muscle tissue oxygenation could be observed at both erector spinae muscle at S1 level and gastrocnemius during and after acupuncture stimulation to ipsilateral erector spinae at S1 level. The subjects were ten healthy males. Muscle oxygenation was monitored by near infrared spectroscopy (NIRS), and the probes were placed on the right side of the erector spinae muscle at S1 level (Guanyuanshu, BL26) and the belly of the gastrocnemius on the right (Chengjin, BL56)...
2016: Advances in Experimental Medicine and Biology
Shiho Yamabata, Hirokazu Shiraishi, Mai Munechika, Hideki Fukushima, Yoshiyuki Fukuoka, Tatsuya Hojo, Takeshi Shirayama, Motoyuki Horii, Satoaki Matoba, Toshikazu Kubo
OBJECTIVES: We investigated the effects of electrical stimulation therapy on cutaneous and muscle blood flow in critical limb ischemia patients following regenerative therapy. METHODS: Three groups were studied: 10 healthy young subjects, 10 elderly subjects, and 7 critical limb ischemia patients after regenerative therapy. After 5 min rest, electrical stimulation was applied at 5 Hz on the tibialis anterior muscle for 10 min. We estimated the relative changes in oxyhemoglobin and total hemoglobin compared to the basal values at rest (Δ[HbO2], Δ[Hbtot]), which reflected the blood flow in the skin and muscle layer, and we simultaneously measured the tissue O2 saturation (StO2) throughout the electrical stimulation and recovery phase by near-infrared spectroscopy...
2016: SAGE Open Medicine
Ligia Simões Braga Boisserand, Benjamin Lemasson, Lydiane Hirschler, Anaïck Moisan, Violaine Hubert, Emmanuel L Barbier, Chantal Rémy, Olivier Detante
Recent advances in MRI methodology, such as microvascular and brain oxygenation (StO2) imaging, may prove useful in obtaining information about the severity of the acute stroke. We assessed the potential of StO2 to detect the ischaemic core in the acute phase compared to apparent diffusion coefficient and to predict the final necrosis. Sprague-Dawley rats (n = 38) were imaged during acute stroke (D0) and 21 days after (D21). A multiparametric MRI protocol was performed at 4.7T to characterize brain damage within three region of interest: 'LesionD0' (diffusion), 'Mismatch' representing penumbra (perfusion/diffusion) and 'Hypoxia' (voxels < 40% of StO2 within the region of interest LesionD0)...
July 27, 2016: Journal of Cerebral Blood Flow and Metabolism
Kaitlin M McLay, James E Gilbertson, Silvia Pogliaghi, Donald H Paterson, Juan M Murias
The reperfusion rate of near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2 ) represent vascular responsiveness. This study examined if the reperfusion slope of StO2 is sensitive to different ischemic conditions (i.e., a dose-response) and if differences exist between two groups of different fitness levels. Nine healthy trained (T; Age: 25 ± 3 yr; VO2max : 63.4 ± 6.7 ml kg(-1)  min(-1) ) and nine healthy untrained (UT; Age: 21 ± 1 yr; VO2max : 46.6 ± 2.5 ml kg(-1)  min(-1) ) men performed a series of vascular occlusion tests of different durations (30 s, 1 min, 2 min, 3 min, and 5 min), each separated by 30 min...
July 18, 2016: Experimental Physiology
Jarich W Spliethoff, Lisanne L de Boer, Mark A J Meier, Warner Prevoo, Jeroen de Jong, Torre M Bydlon, Henricus J C M Sterenborg, Jacobus A Burgers, Benno H W Hendriks, Theodoor J M Ruers
OBJECTIVES: Difficulties in obtaining a representative tissue sample are a major obstacle in timely selecting the optimal treatment for patients with lung cancer or other malignancies. Having a modality to provide needle guidance and confirm the biopsy site selection could be of great clinical benefit, especially when small masses are targeted. The objective of this study was to evaluate whether diffuse reflectance spectroscopy (DRS) at the tip of a core biopsy needle can be used for biopsy site confirmation in real time, thereby enabling optimized biopsy acquisition and improving diagnostic capability...
August 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
J Kolbenschlag, A Sogorski, N Kapalschinski, K Harati, M Lehnhardt, A Daigeler, T Hirsch, O Goertz
BACKGROUND: Surgical flaps have become safe and reliable tools in the reconstructive armamentarium. However, total flap loss rates of up to 25% and partial flap loss rates up to 36% are reported in the literature, most often due to insufficient perfusion and the resulting hypoxia. Therefore, a reliable, non-invasive and effective way to improve the microcirculation of surgical flaps is desirable. Remote Ischemic Conditioning (RIC) is the repeated application of non-damaging cycles of ischemia and reperfusion on an organ remote to the tissue to be conditioned...
July 5, 2016: Plastic and Reconstructive Surgery
O Shannon, M Barlow, L Duckworth, D R Woods, T Barker, A Grindrod, A Griffiths, J P O'Hara
The purpose of this study was to assess the reliability of a pre-loaded 1 500-m treadmill time trial, conducted in moderate normobaric hypoxia. 8 trained runners/triathletes (24±3 years, 73.2±8.1 kg, 182.5±6.5 cm, altitude specific V˙O2max: 52.9±5.5 ml·kg(-1)·min(-1)) completed 3 trials (the first as a familiarisation), involving 2, 15-min running bouts at 45% and 65% V˙O2max, respectively, and a 1 500-m time trial in moderate normobaric hypoxia equivalent to a simulated altitude of 2 500 m (FiO2~15%)...
September 2016: International Journal of Sports Medicine
Marie-Laurence Guye, Cyrus Motamed, Sarah Chemam, Nicolas Leymarie, Stéphanie Suria, Grégoire Weil
BACKGROUND: Patients undergoing free-flap reconstruction after head and neck cancer may develop free flap complications. In the perioperative period, haemoglobin content and oxygen tissue Saturation (StO2) measured directly on the free flap reflect peripheral tissue oxygenation. However, in this type of surgery, StO2 cannot always be applied directly or proximate to the free flap. The aim of this study was to assess the possible value of StO2 measured at the thenar eminence and other 24 hour perioperative factors on free flap complications...
June 16, 2016: Anaesthesia, Critical Care & Pain Medicine
Yi-Ping Chang, Kao-Shang Shih, Hongsen Chiang, Hsiao-Li Ma, Leou-Chyr Lin, Wei-Chen Peng, Che-Sheng Wen, Hsing-Kuo Wang
BACKGROUND: Early microcirculatory responses after experimental tenotomy are critical to the healing of tendons and their ultimate tensile strength. The effects of changes in microcirculation on the outcomes of tendon healing, however, have not been determined. OBJECTIVES: To assess microcirculation values in injured Achilles tendons in the first 3 months after surgical repair and to correlate the inter-limb microcirculatory changes with functional outcomes at 3 and 6 months after surgery...
June 16, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Michael Stuart Green, Sankalp Sehgal, Rayhan Tariq
Standard hemodynamic monitoring such as blood pressure and pulse oximetry may only provide a crude estimation of organ perfusion in the critical care setting. Near-infrared spectroscopy (NIRS) is based on the same principle as a pulse oximeter and allows continuous noninvasive monitoring of hemoglobin oxygenation and deoxygenation and thus tissue saturation "StO2" This review aims to provide an overview of NIRS technology principles and discuss its current clinical use in the critical care setting. The study selection was performed using the PubMed database to find studies that investigated the use of NIRS in both the critical care setting and in the intensive care unit...
September 2016: Seminars in Cardiothoracic and Vascular Anesthesia
Hiroshi Akima, Ryosuke Ando
INTRODUCTION: The purpose of this study was to assess oxygenation and neuromuscular activation of the quadriceps femoris muscle group, including the vastus intermedius (VI), during a fatiguing contraction. METHODS: Eleven healthy men performed an isometric knee extension at 50% of the maximum voluntary contraction until failure. Near-infrared spectroscopy was used to measure tissue oxygen saturation (StO2 ), and surface electromyography was used to quantify the median frequency (MF) of the four individual quadriceps femoris muscles...
May 19, 2016: Clinical Physiology and Functional Imaging
Diego Orbegozo Cortés, Lokmane Rahmania, Marian Irazabal, Carlos Santacruz, Vito Fontana, Daniel De Backer, Jacques Creteur, Jean-Louis Vincent
BACKGROUND: Acute respiratory distress syndrome (ARDS) is associated with vascular endothelial dysfunction. The resultant microvascular reactivity can be assessed non-invasively using near-infrared spectroscopy (NIRS) and a vascular occlusion test (VOT) and changes have been correlated with severity of organ dysfunction and mortality in other critically ill populations. We used NIRS to study the presence of microcirculatory alterations in patients with ARDS. METHODS: We studied 27 healthy volunteers and 32 ARDS patients admitted to our intensive care department...
2016: Respiratory Research
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