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https://www.readbyqxmd.com/read/29346183/near-infrared-spectroscopy-to-predict-organ-failure-and-outcome-in-sepsis-the-assessing-risk-in-sepsis-using-a-tissue-oxygen-saturation-aristos-study
#1
Stephen P J Macdonald, Frances B Kinnear, Glenn Arendts, Kwok M Ho, Daniel M Fatovich
OBJECTIVES: Sepsis is acute organ dysfunction in the setting of infection. An accurate diagnosis is important to guide treatment and disposition. Tissue oxygen saturation (StO2) can be estimated noninvasively by near-infrared spectroscopy (NIRS), and may be an indicator of microcirculatory dysfunction in early sepsis. We aimed to determine the utility of StO2 for sepsis recognition and outcome prediction among patients presenting to the emergency department (ED) with infection. PATIENTS AND METHODS: A multicentre, prospective, observational cohort study recruited patients who were being admitted to hospital with infection...
January 17, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29261592/whole-blood-and-hextend-bookends-of-modern-tactical-combat-casualty-care-field-resuscitation-and-starting-point-for-multi-functional-resuscitation-fluid-development
#2
Forest R Sheppard, Thomas A Mitchell, Antoni R Macko, Darren M Fryer, Leasha J Schaub, Kassandra M Ozuna, Jacob J Glaser
BACKGROUND: Hemorrhage is the leading cause of preventable death in traumatically injured civilian and military populations. Pre-hospital resuscitation largely relies on crystalloid and colloid intra-vascular expansion, as whole blood and component blood therapy are logistically arduous. In this experiment, we evaluated the bookends of Tactical Combat Casualty Care Guidelines recommendations of pre-hospital resuscitation with Hextend and whole blood in a controlled hemorrhagic shock model within non-human primates, as means of a multi-functional resuscitative fluid development...
December 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29233190/microvascular-effects-of-intravenous-esmolol-in-patients-with-normal-cardiac-function-undergoing-postoperative-atrial-fibrillation-a-prospective-pilot-study-in-cardiothoracic-surgery
#3
William Fornier, Matthias Jacquet-Lagrèze, Thomas Collenot, Priscilla Teixeira, Philippe Portran, Rémi Schweizer, Michel Ovize, Jean-Luc Fellahi
BACKGROUND: Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic instability. Microcirculatory effects of POAF and esmolol have not yet been investigated. We hypothesized that POAF without hemodynamic instability would induce microvascular dysfunction which could be reversed by intravenous esmolol. METHODS: Twenty-five cardiothoracic surgical patients with POAF were included in the study...
December 12, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29188096/cerebral-time-domain-nirs-reproducibility-analysis-optical-properties-hemoglobin-species-and-tissue-oxygen-saturation-in-a-cohort-of-adult-subjects
#4
Giacomo Giacalone, Marta Zanoletti, Davide Contini, Rebecca Re, Lorenzo Spinelli, Luisa Roveri, Alessandro Torricelli
The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO2) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29175135/a-systematic-review-of-near-infrared-spectroscopy-in-flap-monitoring-current-basic-and-clinical-evidence-and-prospects
#5
REVIEW
Yu Kagaya, Shimpei Miyamoto
BACKGROUND: Near-infrared spectroscopy (NIRS) has been reported to be a reliable non-invasive modality for free flap monitoring; however, the history of its application in flap monitoring is short, and there is no definite consensus regarding its use at present. OBJECTIVES: The aim of this review is to clarify the evidence related to post-operative flap monitoring using NIRS and examine its appropriateness and usability. MATERIALS AND METHODS: The PubMed and Web of Science databases were searched using the strings "flap monitoring AND near-infrared spectroscopy" and "flap monitoring AND tissue oxygen saturation," with a study period from inception to December 31, 2016...
November 22, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29114952/age-related-microvascular-dysfunction-novel-insight-from-near-infrared-spectroscopy
#6
Ryan Rosenberry, Madison Munson, Susie Chung, T Jake Samuel, Jordan Patik, Wesley J Tucker, Mark J Haykowsky, Michael D Nelson
Near-infrared spectroscopy (NIRS) has emerged as a promising tool to evaluate vascular reactivity in vivo. Whether this approach can be used to assess age-related impairments in microvascular function has not been tested. Tissue oxygen saturation (StO2 ) post-occlusion recovery kinetics were measured in two distinct age groups (<35 year and >65 years) using NIRS placed over the flexor digitorum profundus. Key end-points included: (1) the desaturation rate during cuff occlusion; (2) the lowest StO2  value obtained during ischemia (StO2min ); (3) StO2  reperfusion rate; (4) the highest StO2  value reached after cuff release (StO2max ); and (5) the reactive hyperemia area under the curve (AUC)...
November 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29113960/lesion-oxygenation-associates-with-clinical-outcomes-in-premalignant-and-early-stage-head-and-neck-tumors-treated-on-a-phase-1-trial-of-photodynamic-therapy
#7
Peter H Ahn, Jarod C Finlay, Shannon M Gallagher-Colombo, Harry Quon, Bert W O'Malley, Gregory S Weinstein, Ara Chalian, Kelly Malloy, Thomas Sollecito, Martin Greenberg, Charles B Simone, Sally McNulty, Alexander Lin, Timothy C Zhu, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Keith A Cengel, Theresa M Busch
BACKGROUND: We report on a Phase 1 trial of photodynamic therapy (PDT) for superficial head and neck (H&N) lesions. Due to known oxygen dependencies of PDT, translational measurements of lesion hemoglobin oxygen saturation (StO2) and blood volume (tHb) were studied for associations with patient outcomes. METHODS: PDT with aminolevulinc acid (ALA) and escalating light doses was evaluated for high-grade dysplasia, carcinoma-in-situ, and microinvasive carcinomas of the H&N...
November 4, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29084009/microvascular-reactivity-assessed-by-near-infrared-spectroscopy-and-a-vascular-occlusion-test-is-associated-with-patient-outcomes-following-cardiac-surgery-a-prospective-observational-study
#8
Ethan Butler, Sajeev Mahendran, John Nguyen, Anders Aneman
BACKGROUND: Microvascular dysfunction in patients admitted to the ICU following cardiac surgery may be related to perioperative complications and increased resource utilisation even in the presence of acceptable systemic haemodynamic variables. OBJECTIVES: To assess the relationship between microvascular impairment using peripheral near-infrared spectroscopy at ICU admission and 6 h postadmission and the duration of mechanical ventilatory support, length of stay in ICU and in hospital...
October 27, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29066597/muscle-oxygenation-profiles-between-active-and-inactive-muscles-with-nitrate-supplementation-under-hypoxic-exercise
#9
Masahiro Horiuchi, Junko Endo, Shohei Dobashi, Yoko Handa, Masataka Kiuchi, Katsuhiro Koyama
Whether dietary nitrate supplementation improves exercise performance or not is still controversial. While redistribution of sufficient oxygen from inactive to active muscles is essential for optimal exercise performance, no study investigated the effects of nitrate supplementation on muscle oxygenation profiles between active and inactive muscles. Nine healthy males performed 25 min of submaximal (heart rate ~140 bpm; EXsub) and incremental cycling (EXmax) until exhaustion under three conditions: (A) normoxia without drink; (B) hypoxia (FiO2 = 13...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/28954987/tissue-oxygenation-index-reflects-changes-in-forearm-blood-flow-after-brief-ischemia
#10
Hiroyuki Kinoshita, Takahiko Akahori, Emi Nakamura, Hazuki Okawa, Shinji Kawahito, Hiroshi Kitahata, Yoshihiro Fujiwara
Whether the near-infrared spectroscopy (NIRS) technology correctly detects the changes in oxygenation related to ischemia and reperfusion of organs and tissues other than brain remains unclear. The present study examined how different tissue oxygenation parameters derived from NIRS reflect the changes in the forearm blood flow (FBF) according to the brief ischemia and the subsequent reperfusion, and whether values of these parameters move in parallel with the medial and lateral sides of FBF. Thirteen volunteers underwent the prospective observational study...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28931323/near-infrared-spectroscopy-can-detect-differences-in-vascular-responsiveness-to-a-hyperglycaemic-challenge-in-individuals-with-obesity-compared-to-normal-weight-individuals
#11
Rogério Nogueira Soares, Raylene A Reimer, Zaid Alenezi, Patricia K Doyle-Baker, Juan Manuel Murias
OBJECTIVE: To examine whether the near-infrared spectroscopy combined with vascular occlusion test technique could detect differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity. METHODS: A total of 16 normal-weight individuals (body mass index, 21.3 ± 1.7 kg/m(2)) and 13 individuals with obesity (body mass index, 34.4 ± 2.0 kg/m(2)) were submitted to five vascular occlusion tests (Pre, 30, 60, 90 and 120 min after glucose challenge)...
September 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28930916/peripheral-muscle-near-infrared-spectroscopy-nirs-variables-are-altered-early-in-septic-shock
#12
Diego Orbegozo, Fuhong Su, Keliang Xie, Lokmane Rahmania, Fabio Silvio Taccone, Daniel De Backer, Jean-Louis Vincent, Jacques Creteur
BACKGROUND: Non-invasive evaluation of muscle perfusion using near infrared spectroscopy (NIRS) coupled with a vascular occlusion test (VOT) may provide an early and simple marker of altered perfusion and microcirculatory function in sepsis. OBJECTIVE: To compare the time-course of NIRS-derived variables with systemic measures of perfusion in an experimental model of peritonitis. METHODS: Peritonitis was induced in eight anesthetized, mechanically ventilated, adult sheep (24-34 Kg), by injecting autologous feces into the peritoneal cavity...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28885215/hyperspectral-imaging-as-a-novel-diagnostic-tool-in-microcirculation-of-wounds
#13
Georg Daeschlein, Inga Langner, Thomas Wild, Sebastian von Podewils, Claudia Sicher, Thomas Kiefer, Michael Jünger
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic wound management it is of utmost importance to realize and parametrize wound bed perfusion to verify actual, and plan further treatment by noninvasive diagnostics. Up to now monitoring is based on visual inspection of wounds as conventionally practiced over more than decades. The main problems of visual inspection are the lack of standardization and comparability because of interindividual variations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28854512/cerebral-oxygenation-and-desaturations-in-preterm-infants-a-longitudinal-data-analysis
#14
Benjamin Mayer, Moritz Pohl, Helmut D Hummler, Manuel B Schmid
OBJECTIVE: Hypoxemic episodes commonly occur in very preterm infants and may be associated with several adverse effects. Cerebral tissue oxygen saturation (StO2) as measured by near infrared spectroscopy (NIRS) may be a useful measure to assess brain oxygenation. However, knowledge on variability of StO2 is limited in preterm infants at this time, so StO2 dependency on arterial oxygenation (SpO2) and heart rate (HR) was assessed in preterm infants using statistical methods of time series analysis...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28819691/hypoxia-affects-tissue-oxygenation-differently-in-the-thigh-and-calf-muscles-during-incremental-running
#15
Takuya Osawa, Takuma Arimitsu, Hideyuki Takahashi
PURPOSE: The present study was performed to determine the impact of hypoxia on working muscle oxygenation during incremental running, and to compare tissue oxygenation between the thigh and calf muscles. METHODS: Nine distance runners and triathletes performed incremental running tests to exhaustion under normoxic and hypoxic conditions (fraction of inspired oxygen = 0.15). Peak pulmonary oxygen uptake ([Formula: see text]) and tissue oxygen saturation (StO2) were measured simultaneously in both the vastus lateralis and medial gastrocnemius...
October 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28717916/colon-perfusion-patterns-during-colorectal-resection-using-visible-light-spectroscopy
#16
Henry Hoffmann, Tarik Delko, Philipp Kirchhoff, Rachel Rosenthal, Juliane Schäfer, Marko Kraljević, Christoph Kettelhack
BACKGROUND: The impact of blood supply to the anastomosis on development of anastomotic leakage is still a matter of debate. Considering that bowel perfusion may be affected by manipulation during surgery, perfusion assessment of the anastomosis alone may be of limited value. We propose perfusion assessment at different time points during surgery to explore the dynamics of bowel perfusion during colorectal resection and its impact on outcome. METHODS: In this prospective cohort study, patients undergoing elective colorectal resection were eligible...
November 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28715342/quantitative-evaluation-of-rehabilitation-effect-on-peripheral-circulation-of-diabetic-foot
#17
Yao-Kuang Huang, Chang-Cheng Chang, Pin-Xing Lin, Bor-Shyh Lin
Diabetics may encounter different foot problems, which easily lead to infection, ulcers, and increased risk of amputation due to nerve or vascular injury. In order to reduce the risk of amputation, Buerger's exercise is one of the frequently used rehabilitation to improve the blood circulation in the lower limbs. However, it is difficult to evaluate the rehabilitation efficiency of Buerger's exercise objectively. In this study, a novel non-invasively optical system was developed to non-invasively monitor the change of the foot blood circulation before and after long-term Buerger's exercise...
July 13, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28702902/oxygenation-status-in-chronic-leg-ulcer-after-topical-hemoglobin-application-may-act-as-a-surrogate-marker-to-find-the-best-treatment-strategy-and-to-avoid-ineffective-conservative-long-term-therapy
#18
Maximilian Petri, Ingo Stoffels, Klaus Griewank, Jithin Jose, Peter Engels, Andrea Schulz, Harald Pötzschke, Philipp Jansen, Dirk Schadendorf, Joachim Dissemond, Joachim Klode
PURPOSE: Chronic leg ulcers can be a challenge to treat and long-term therapy a significant cost factor in western public health budgets. Objective wound assessment assays enabling selection of appropriate wound therapy regimes would be desirable. Oxygenation status in ulcer tissue has obtained increased attention as a relevant factor in wound healing. To increase oxygenation in wounds, a topical hemoglobin spray was developed. Although favorable results have been noted, the link between clinical efficacy and the mode of action has not been demonstrated...
July 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28693932/muscle-tissue-saturation-compared-with-muscle-tissue-perfusion-during-low-blood-flows-an-experimental-study
#19
Sisse Anette Thomassen, Benedict Kjærgaard, Aage Kristian Olsen Alstrup, Ole Lajord Munk, Jørgen Frøkiær, Anders Larsson, Bodil Steen Rasmussen
OBJECTIVE: To investigate whether changes in muscle tissue perfusion measured with positron emission tomography would be reflected by parallel changes in muscle tissue oxygen saturation (StO2) measured using near-infrared spectroscopy during high and low blood flow levels achieved using cardiopulmonary bypass (CPB) in an animal model. DESIGN: A prospective, randomized study. SETTING: Research laboratory, single institution. PARTICIPANTS: Eight pigs (69-71 kg)...
March 22, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28685457/physiological-effects-of-continuous-colored-light-exposure-on-mayer-wave-activity-in-cerebral-hemodynamics-a-functional-near-infrared-spectroscopy-fnirs-study
#20
A J Metz, S D Klein, F Scholkmann, U Wolf
We are increasingly exposed to colored light, but its impact on human physiology is not yet extensively investigated. In the present study we aimed to determine the effects of colored light on human cerebral Mayer wave activity (MWA). We measured oxy- ([O2Hb]), deoxy- ([HHb]), total hemoglobin ([tHb]) concentrations and tissue oxygen saturation (StO2) by functional near-infrared spectroscopy (fNIRS) in the left and right pre-frontal cortex (L-PFC, R-PFC) of 17 subjects (median age: 29 years, 6 women). In a randomized crossover design subjects were exposed to blue, red, green, and yellow LED light for 10 min...
2017: Advances in Experimental Medicine and Biology
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