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https://www.readbyqxmd.com/read/29661044/dmek-versus-dsaek-for-fuchs-endothelial-dystrophy-a-meta-analysis
#1
Raquel Esteves Marques, Paulo Silva Guerra, David Cordeiro Sousa, Ana Inês Gonçalves, Ana Miguel Quintas, Walter Rodrigues
PURPOSE: To compare the safety and efficacy profiles of Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in adult patients with Fuchs' endothelial dystrophy. METHODS: Electronic database search on MEDLINE and CENTRAL from inception to August 2017. We included all comparative studies of DMEK versus DSAEK in patients with diagnosed Fuchs' endothelial dystrophy. Studies assessing rescue procedures were excluded to minimize bias...
April 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29648815/peptidomimetic-based-multi-domain-targeting-offers-critical-evaluation-of-a%C3%AE-structure-and-toxic-function
#2
Sunil Kumar, Anja Henning, Mazin Magzoub, Andrew D Hamilton
The processes associated with the conversion of amyloid beta (Aβ) into intractable amyloid fibers are considered to be pivotal events in Alzheimer's disease (AD). The prevailing hypothesis stipulates that the pre-amyloid oligomers of Aβ are the main culprits associated with the onset and progression of AD, which has prompted efforts to search for therapeutic agents with the ability to inhibit Aβ oligomerization and amyloidogenesis. However, the lack of clinical progress is impeded by the limited structural information about the neurotoxic oligomers...
April 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29615073/advanced-airway-management-in-hoist-and-longline-operations-in-mountain-hems-considerations-in-austere-environments-a-narrative-review-this-review-is-endorsed-by-the-international-commission-for-mountain-emergency-medicine-icar-medcom
#3
REVIEW
Urs Pietsch, Jürgen Knapp, Oliver Kreuzer, Ludwig Ney, Giacomo Strapazzon, Volker Lischke, Roland Albrecht, Patrick Phillips, Simon Rauch
BACKGROUND: Providing sufficient oxygenation and ventilation is of paramount importance for the survival of emergency patients. Therefore, advanced airway management is one of the core tasks for every rescue team. Endotracheal intubation is the gold standard to secure the airway in the prehospital setting. This review aims to highlight special considerations for advanced airway management preceding human external cargo (HEC) evacuations. METHODS: We systematically searched MEDLINE, EMBASE, and PubMed in August 2017 for articles on airway management and ventilation in patients before hoist or longline operation in HEMS...
April 3, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29611607/the-epidemiology-of-operations-performed-by-the-national-sea-rescue-institute-of-south-africa-over-a-5-year-period
#4
Elaine Erasmus, Cleeve Robertson, Daniel Jacobus van Hoving
BACKGROUND: Injuries remain a major contributor of morbidity and mortality worldwide, with drowning accounting for 7% of all injury-related deaths with rates of between 4 and 8 per 100,000. The African region has death rates comparable to most low-income countries. Non-fatal drowning in Africa remains unquantified but it is estimated to be ten times higher than the fatal drowning rate. Timely search and rescue, initial resuscitation and rapid transportation to definitive care play a crucial role in preventing injury- related morbidity and mortality...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29605259/gene-expression-profiling-coupled-with-connectivity-map-database-mining-reveals-potential-therapeutic-drugs-for-hirschsprung-disease
#5
Shang-Jie Xiao, Xiao-Chun Zhu, Hua Deng, Wei-Ping Zhou, Wen-Yi Yang, Li-Ke Yuan, Jiang-Yu Zhang, Song Tian, Lu Xu, Liang Zhang, Hui-Min Xia
BACKGROUND: Hirschsprung disease (HD) is a congenital intestinal anomaly resulting from a failure to form enteric ganglia in the lower bowel. Surgery is the main therapeutic strategy, although neural stem cell transplantation has recently shown promise. However, HD remains a challenging disorder to treat. Our aim was to identify drugs that could counteract the dysregulated pathways in HD and could thus be potential novel therapies. METHODS: We used microarray analysis to identify genes differentially expressed in ganglionic and aganglionic bowel samples from eight children with HD...
March 4, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29601182/sniffing-entrapped-humans-with-sensor-arrays
#6
Andreas T Güntner, Nicolay J Pineau, Paweł Mochalski, Helmut Wiesenhofer, Agapios Agapiou, Christopher A Mayhew, Sotiris E Pratsinis
Earthquakes are lethal natural disasters frequently burying people alive under collapsed buildings. Tracking entrapped humans from their unique volatile chemical signature with hand-held devices would accelerate urban search and rescue (USaR) efforts. Here, a pilot study is presented with compact and orthogonal sensor arrays to detect the breath- and skin-emitted metabolic tracers acetone, ammonia, isoprene, CO2 , and relative humidity (RH), all together serving as sign of life. It consists of three nanostructured metal-oxide sensors (Si-doped WO3 , Si-doped MoO3 , and Ti-doped ZnO), each specifically tailored at the nanoscale for highly sensitive and selective tracer detection along with commercial CO2 and humidity sensors...
April 5, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29597147/caffeic-acid-phenethyl-ester-down-regulates-claudin-2-expression-at-the-transcriptional-and-post-translational-levels-and-enhances-chemosensitivity-to-doxorubicin-in-lung-adenocarcinoma-a549-cells
#7
Hiroyuki Sonoki, Asami Tanimae, Takumi Furuta, Satoshi Endo, Toshiyuki Matsunaga, Kenji Ichihara, Akira Ikari
Claudin-2 is highly expressed in human lung adenocarcinoma cells and involved in the promotion of proliferation. Here, we searched for a compound, which can decrease claudin-2 expression using lung adenocarcinoma A549 cells. In the screening using compounds included in royal jelly and propolis, the protein level of claudin-2 was dose-dependently decreased by caffeic acid phenethyl ester (CAPE), whereas the mRNA level and promoter activity were only decreased by 50 μM CAPE. These results suggest that CAPE down-regulates claudin-2 expression mediated by two different mechanisms...
March 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29596105/attention-health-care-leaders-literature-review-deems-baccalaureate-nurses-improve-patient-outcomes
#8
Deborah O'Brien, Mary Knowlton, Ramona Whichello
AIM: This review of studies conducted since the 2011 publication of the Institute of Medicine (IOM) report "The Future of Nursing: Leading Change, Advancing Health" evaluates the current state of evidence showing an association between an increased ratio of BSN-prepared nursing staff and improved patient outcomes. BACKGROUND: The IOM established a nationwide goal to increase the number of BSN nurses to 80 percent by 2020 to meet the challenges seen in today's health care environment...
March 28, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29596095/dexamethasone-as-an-adjuvant-for-caudal-blockade-in-pediatric-surgical-patients-a-systematic-review-and-meta-analysis
#9
Matthew A Chong, Daniel J Szoke, Nicolas M Berbenetz, Cheng Lin
BACKGROUND: Caudal block is commonly used to provide postoperative analgesia after pediatric surgery in the lower abdomen. Typically administered as a single-shot technique, 1 limitation of this block is the short duration of analgesia. To overcome this, dexamethasone has been used as an adjuvant to prolong block duration. However, there are concerns about steroid-related morbidity and the optimal route of dexamethasone administration (eg, caudal or intravenous) is unknown. METHODS: We conducted a systematic review and random-effects meta-analysis of randomized controlled trials recruiting pediatric surgical patients receiving a caudal block for surgical anesthesia or postoperative analgesia...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29593072/a-strategy-to-isolate-modifiers-of-caenorhabditis-elegans-lethal-mutations-investigating-the-endoderm-specifying-ability-of-the-intestinal-differentiation-gata-factor-elt-2
#10
Tobias Wiesenfahrt, Jingjie Duanmu, Frances Snider, Don Moerman, Vinci Au, Erica Li-Leger, Stephane Flibotte, Dylan M Parker, Craig J Marshall, Erin Osborne Nishimura, Paul E Mains, James D McGhee
The ELT-2 GATA factor normally functions in differentiation of the C. elegans endoderm, downstream of endoderm specification. We have previously shown that, if ELT-2 is expressed sufficiently early, it is also able to specify the endoderm and to replace all other members of the core GATA-factor transcriptional cascade (END-1, END-3, ELT-7). However, such rescue requires multiple copies (and presumably overexpression) of the end-1p::elt-2 cDNA transgene; a single copy of the transgene does not rescue. We have made this observation the basis of a genetic screen to search for genetic modifiers that allow a single copy of the end-1p::elt-2 cDNA transgene to rescue the lethality of the end-1 end-3 double mutant...
March 28, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29584923/rescue-therapy-for-procedural-complications-associated-with-deployment-of-flow-diverting-devices-in-cerebral-aneurysms
#11
Fawaz Al-Mufti, Krishna Amuluru, Eric R Cohen, Vikas Patel, Mohammad El-Ghanem, Ethan Wajswol, Vincent Dodson, Sarmad Al-Marsoummi, Neil Majmundar, Neha S Dangayach, Rolla Nuoman, Chirag D Gandhi
Flow diverting devices (FDDs) have revolutionized the treatment of morphologically complex intracranial aneurysms such as wide-necked, giant, or fusiform aneurysms. Although FDDs are extremely effective, they carry a small yet significant risk of intraprocedural complications. As the implementation of these devices increases, the ability to predict and rapidly treat complications, especially those that are iatrogenic or intraprocedural in nature, is becoming increasingly more necessary.Our objective in this paper is to provide a descriptive summary of the various types of intraprocedural complications that may occur during FDDs deployment and how they may best be treated...
March 22, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29573961/impact-of-dosage-timing-of-once-daily-inhaled-corticosteroids-in-asthma-a-systematic-review-and-meta-analysis
#12
Jae-Uk Song, Hye Kyeong Park, Jonghoo Lee
BACKGROUND: Once-daily inhaled corticosteroids (ICSs) are widely used as first-line therapy in patients with asthma. OBJECTIVE: To compare the efficacy of ICSs administered once daily in the morning or evening as determined by lung function. METHODS: Medline, Embase, and the Cochrane Central Register were searched for relevant clinical trials. The primary outcome was lung function assessed as trough forced expiratory volume in 1 second and peak expiratory flow at end point...
March 21, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29556876/functional-analysis-razip1-transporter-of-the-zip-family-from-the-ectomycorrhizal-zn-accumulating-russula-atropurpurea
#13
Tereza Leonhardt, Jan Sácký, Pavel Kotrba
A search of R. atropurpurea transcriptome for sequences encoding the transporters of the Zrt-, Irt-like Protein (ZIP) family, which are in eukaryotes integral to Zn supply into cytoplasm, allowed the identification of RaZIP1 cDNA with a predicted product belonging to ZIP I subfamily; it was subjected to functional studies in mutant Saccharomyces cerevisiae strains. The expression of RaZIP1, but not RaZIP1H208A or RaZIP1H232A mutants lacking conserved-among-ZIPs transmembrane histidyls, complemented Zn uptake deficiency in zrt1Δzrt2Δ yeasts...
March 19, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29551528/challenges-of-military-health-service-support-in-mountain-warfare
#14
REVIEW
Raimund Lechner, Thomas Küpper, Markus Tannheimer
INTRODUCTION: History is full of examples of the influence of the mountain environment on warfare. The aim of this article is to identify the main environmental hazards and summarize countermeasures to mitigate the impact of this unique environment. METHODS: A selective PubMed and Internet search was conducted. Additionally, we searched bibliographies for useful supplemental literature and included the recommendations of the leading mountain medicine and wilderness medicine societies...
March 16, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29547887/an-evaluation-of-navy-en-route-care-training-using-a-high-fidelity-medical-simulation-scenario-of-interfacility-patient-transport
#15
Christine A DeForest, Virginia Blackman, John E Alex, Lauren Reeves, Alejandra Mora, Crystal Perez, Joseph Maddry, Domenique Selby, Benjamin Walrath
Introduction: Military prehospital and en route care (ERC) directly impacts patient morbidity and mortality. Provider knowledge and skills are critical variables in the effectiveness of ERC. No Navy doctrine defines provider choice for patient transport or requires standardized provider training. Frequently, Search and Rescue Medical Technicians (SMTs) and Navy Nurses (ERC RNs) are tasked with this mission though physicians have also been used. Navy ERC provider training varies greatly by professional role...
March 14, 2018: Military Medicine
https://www.readbyqxmd.com/read/29547491/prophylactic-probiotics-for-cancer-therapy-induced-diarrhoea-a-meta-analysis
#16
Hannah R Wardill, Ysabella Z A Van Sebille, Matthew A Ciorba, Joanne M Bowen
PURPOSE OF REVIEW: Strong preclinical data support prophylactic probiotics as an effective preventive strategy for diarrhoea secondary to anticancer therapies. To determine the composite evidence that this approach translates to the clinic, we performed a meta-analysis of randomized controlled trials (RCTs) of prophylactic probiotics for the prevention of cancer therapy induced diarrhoea. RECENT FINDINGS: A three-step search strategy was used to identify relevant studies (1 June 2000-1 June 2017) investigating probiotic intervention for diarrhoea secondary to any cancer therapy (cytotoxic, targeted and immunotherapies)...
March 14, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29542112/laryngeal-mask-airway-versus-bag-mask-ventilation-or-endotracheal-intubation-for-neonatal-resuscitation
#17
REVIEW
Mosarrat J Qureshi, Manoj Kumar
BACKGROUND: Providing effective positive pressure ventilation is considered to be the single most important component of successful neonatal resuscitation. Ventilation is frequently initiated manually with bag and face mask (BMV) followed by endotracheal intubation if respiratory depression continues. These techniques may be difficult to perform successfully resulting in prolonged resuscitation or neonatal asphyxia. The laryngeal mask airway (LMA) may achieve initial ventilation and successful resuscitation faster than a bag-mask device or endotracheal intubation...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29533427/benefit-of-critical-care-flight-paramedic-trained-search-and-rescue-corpsmen-in-treatment-of-severely-injured-aviators
#18
Ryan W Snow, Wayne Papalski, John Siedler, Brendon Drew, Benjamin Walrath
During routine aircraft start-up procedures at a US Naval Air Station, an aviation mishap occurred, resulting in the pilot suffering a traumatic brain injury and the copilot acquiring bilateral hemopneumothoraces, a ruptured diaphragm, and hepatic and splenic contusions. The care of both patients, including at point of injury and en route to the closest trauma center, is presented. This case demonstrates a benefit from advanced life-saving interventions and critical care skills beyond the required scope of practice of search and rescue medical technicians as dictated by relevant instructions...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/29525230/seroprevalence-of-leptospirosis-in-working-dogs
#19
S F Lau, J Y Wong, K H Khor, M A Roslan, M S Abdul Rahman, S K Bejo, R Radzi, A R Bahaman
Working dogs are canine animals that have been trained to assist human beings in carrying out various tasks. They help in guarding property, performing rescues, assisting the visually impaired or physically handicapped, searching for drugs, explosives, and others. Leptospirosis is one of the most widespread zoonotic diseases in the world and a commonly occurring disease of the tropics and subtropics. In Malaysia, all working dogs are normally vaccinated with serovars, Pomona, Icterohaemorrhagiae, Canicola, and Grippotyphosa based on protocols recommended from other countries...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29523018/aromatherapy-for-treatment-of-postoperative-nausea-and-vomiting
#20
REVIEW
Sonia Hines, Elizabeth Steels, Anne Chang, Kristen Gibbons
BACKGROUND: Postoperative nausea and vomiting (PONV) is a common, unpleasant phenomenon and current therapies are not always effective for all patients. Aromatherapy has been suggested as an addition to the available treatment strategies. This review was originally published in 2012 and updated in 2017. OBJECTIVES: The main objective was to establish the efficacy and safety of aromatherapy comparable to standard pharmacological treatments for PONV in adults and children...
March 10, 2018: Cochrane Database of Systematic Reviews
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