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https://www.readbyqxmd.com/read/29446647/management-of-multi-casualty-incidents-in-mountain-rescue-evidence-based-guidelines-of-the-international-commission-for-mountain-emergency-medicine-icar-medcom
#1
Marc Blancher, François Albasini, Fidel Elsensohn, Ken Zafren, Natalie Hölzl, Kyle McLaughlin, Albert R Wheeler, Steven Roy, Hermann Brugger, Mike Greene, Peter Paal
Blancher, Marc, François Albasini, Fidel Elsensohn, Ken Zafren, Natalie Hölzl, Kyle McLaughlin, Albert R. Wheeler III, Steven Roy, Hermann Brugger, Mike Greene, and Peter Paal. Management of multi-casualty incidents in mountain rescue. High Alt Med Biol. 00:000-000, 2018. INTRODUCTION: Multi-Casualty Incidents (MCI) occur in mountain areas. Little is known about the incidence and character of such events, and the kind of rescue response. Therefore, the International Commission for Mountain Emergency Medicine (ICAR MEDCOM) set out to provide recommendations for the management of MCI in mountain areas...
February 15, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29444191/restoration-of-services-in-disrupted-infrastructure-systems-a-network-science-approach
#2
Aybike Ulusan, Ozlem Ergun
Due to the ubiquitous nature of disruptive extreme events, functionality of the critical infrastructure systems (CIS) is constantly at risk. In case of a disruption, in order to minimize the negative impact to the society, service networks operating on the CIS should be restored as quickly as possible. In this paper, we introduce a novel network science inspired measure to quantify the criticality of components within a disrupted service network and develop a restoration heuristic (Cent-Restore) that prioritizes restoration efforts based on this measure...
2018: PloS One
https://www.readbyqxmd.com/read/29443906/a-single-rf-emitter-based-indoor-navigation-method-for-autonomous-service-robots
#3
Tyrone Sherwin, Mikala Easte, Andrew Tzer-Yeu Chen, Kevin I-Kai Wang, Wenbin Dai
Location-aware services are one of the key elements of modern intelligent applications. Numerous real-world applications such as factory automation, indoor delivery, and even search and rescue scenarios require autonomous robots to have the ability to navigate in an unknown environment and reach mobile targets with minimal or no prior infrastructure deployment. This research investigates and proposes a novel approach of dynamic target localisation using a single RF emitter, which will be used as the basis of allowing autonomous robots to navigate towards and reach a target...
February 14, 2018: Sensors
https://www.readbyqxmd.com/read/29425965/the-small-heat-shock-proteins-especially-hspb4-and-hspb5-are-promising-protectants-in-neurodegenerative-diseases
#4
REVIEW
Zhihui Zhu, Georg Reiser
Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain have been observed to be related to the pathology of neurodegenerative diseases, including Parkinson's, Alzheimer's, Alexander's disease, multiple sclerosis, and human immunodeficiency virus-associated dementia. Specifically, sHsps interact with misfolding and damaging protein aggregates, like Glial fibrillary acidic protein in AxD, β-amyloid peptides aggregates in Alzheimer's disease, Superoxide dismutase 1 in Amyotrophic lateral sclerosis and cytosine-adenine-guanine/polyglutamine (CAG/PolyQ) in Huntington's disease, Spinocerebellar ataxia type 3, Spinal-bulbar muscular atrophy, to reduce the toxicity or increase the clearance of these protein aggregates...
February 6, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29422373/international-commission-for-mountain-emergency-medicine-consensus-guidelines-for-on-site-management-and-transport-of-patients-in-canyoning-incidents
#5
REVIEW
Giacomo Strapazzon, Oliver Reisten, Fabien Argenone, Ken Zafren, Greg Zen-Ruffinen, Gordon L Larsen, Inigo Soteras
Canyoning is a recreational activity that has increased in popularity in the last decade in Europe and North America, resulting in up to 40% of the total search and rescue costs in some geographic locations. The International Commission for Mountain Emergency Medicine convened an expert panel to develop recommendations for on-site management and transport of patients in canyoning incidents. The goal of the current review is to provide guidance to healthcare providers and canyoning rescue professionals about best practices for rescue and medical treatment through the evaluation of the existing best evidence, focusing on the unique combination of remoteness, water exposure, limited on-site patient management options, and technically challenging terrain...
February 5, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29421799/an-international-genetic-survey-of-breed-specific-diseases-in-working-dogs-from-the-united-states-israel-and-poland
#6
Lisa G Shaffer, Christina J Ramirez, Patricia Phelps, Maya Aviram, Marta Walczak, Gila Kahila Bar-Gal, Blake C Ballif
Genetic diseases occur in breeds used for law enforcement. As important team members, dogs are expected to operate at peak performance for several years and are significant investments for both the initial purchase and extensive, specialized training. Previous studies have not focused on causes for retirement or euthanasia as genetic (inherited) versus acquired (environmental). We performed direct mutational analysis for breed-specific conditions on samples from 304 dogs including 267 law enforcement (122 US, 87 Israeli, and 58 Polish) and 37 search and rescue dogs...
February 9, 2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29412086/an-ultralightweight-and-living-legged-robot
#7
Tat Thang Vo Doan, Melvin Y W Tan, Xuan Hien Bui, Hirotaka Sato
In this study, we describe the most ultralightweight living legged robot to date that makes it a strong candidate for a search and rescue mission. The robot is a living beetle with a wireless electronic backpack stimulator mounted on its thorax. Inheriting from the living insect, the robot employs a compliant body made of soft actuators, rigid exoskeletons, and flexure hinges. Such structure would allow the robot to easily adapt to any complex terrain due to the benefit of soft interface, self-balance, and self-adaptation of the insect without any complex controller...
February 2018: Soft Robotics
https://www.readbyqxmd.com/read/29407346/associations-between-nurse-education-and-experience-and-the-risk-of-mortality-and-adverse-events-in-acute-care-hospitals-a-systematic-review-of-observational-studies
#8
REVIEW
Li-Anne Audet, Patricia Bourgault, Christian M Rochefort
OBJECTIVES: To provide knowledge from the summarization of the evidence on the: a) associations between nurse education and experience and the occurrence of mortality and adverse events in acute care hospitals, and; b) benefits to patients and organizations of the recent Institute of Medicine's recommendation that 80% of registered nurses should be educated at the baccalaureate degree by 2020. DATA SOURCES: A systematic search of English and French literature was conducted in six electronic databases: 1) Medline, 2) PubMed, 3) CINAHL, 4) Scopus, 5) Campbell, and 6) Cochrane databases...
January 31, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29406173/analgesic-efficacy-of-bilateral-superficial-cervical-plexus-block-for-thyroid-surgery-meta-analysis-and-systematic-review
#9
REVIEW
D Mayhew, N Sahgal, R Khirwadkar, J M Hunter, A Banerjee
BACKGROUND: Thyroid surgery is moderately painful, but is increasingly being considered as a day-case procedure. Bilateral superficial cervical plexus block (BSCPB) provides an adjuvant technique to facilitate this approach, but there is great evidential heterogeneity in randomised controlled trials (RCTs) about its use. METHODS: A systematic search, critical appraisal, and analysis of RCTs was performed. Trials investigating preoperative or postoperative BSCPB compared with control in patients undergoing thyroid surgery via neck incision were included...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29402361/-meta-analysis-of-the-effects-between-endotracheal-intubation-and-laryngeal-mask-airway-for-patients-with-out-of-hospital-cardiac-arrest
#10
Xiangjun Tao, Wei Gu, Xiaojuan Liu, Kaisheng Dong, Ying Wang, Shu Ding
OBJECTIVE: To comprehensively evaluate the resuscitation effect of endotracheal intubation (ETI) ventilation and laryngeal mask airway (LMA) for out-of-hospital cardiac arrest (OHCA). METHODS: Databases such as Cochrane Library, PubMed, Embase, Ebsco, Elsevier, OVID, Springer, Proquest, and China biomedical literature database (CBMdisc), CNKI, Wanfang database, Chinese Science and Technology Journal Full-text Database, VIP Chinese biomedical journal database were searched from the establishment of literature database to December 2017 to study the difference of effects between ETI and LMA for patients with OHCA...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29401643/review-of-non-respiratory-non-cancer-physical-health-conditions-from-exposure-to-the-world-trade-center-disaster
#11
REVIEW
Lisa M Gargano, Kimberly Mantilla, Monique Fairclough, Shengchao Yu, Robert M Brackbill
After the World Trade Center attacks on 11 September 2001 (9/11), multiple cohorts were developed to monitor the health outcomes of exposure. Respiratory and cancer effects have been covered at length. This current study sought to review the literature on other physical conditions associated with 9/11-exposure. Researchers searched seven databases for literature published in English from 2002 to October 2017, coded, and included articles for health condition outcome, population, 9/11-exposures, and comorbidity...
February 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29395284/safety-and-efficacy-of-intravenous-lidocaine-for-pain-management-in-the-emergency-department-a-systematic-review
#12
REVIEW
Lucas Oliveira J E Silva, Kristin Scherber, Daniel Cabrera, Sergey Motov, Patricia J Erwin, Colin P West, M Hassan Murad, M Fernanda Bellolio
STUDY OBJECTIVE: We evaluate the safety and efficacy of intravenous lidocaine in adult patients with acute and chronic pain who are undergoing pain management in the emergency department (ED). METHODS: We searched Ovid CENTRAL, Ovid EMBASE, and Ovid MEDLINE databases for randomized controlled trials and observational studies from inception to January 2017. Efficacy outcomes included reduction in pain scores from baseline to postintervention and need for rescue analgesia...
January 29, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29391776/efficacy-and-side-effects-of-intravenous-theophylline-in-acute-asthma-a-systematic-review-and-meta-analysis
#13
Gulixian Mahemuti, Hui Zhang, Jing Li, Nueramina Tieliwaerdi, Lili Ren
Background and objective: Theophylline has been used for decades to treat both acute and chronic asthma. Despite its longevity in the practitioner's formulary, no detailed meta-analysis has been performed to determine the conditions, including concomitant medications, under which theophylline should be used for acute exacerbations of asthma. We aimed to quantify the usefulness and side effects of theophylline with or without ethylene diamine (aminophylline) in acute asthma, with particular emphasis on patient subgroups, such as children, adults, and concomitant medications...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29343579/identification-of-poxvirus-genome-uncoating-and-dna-replication-factors-with-mutually-redundant-roles
#14
Baoming Liu, Debasis Panda, Jorge D Mendez-Rios, Sundar Ganesan, Linda S Wyatt, Bernard Moss
Genome uncoating is essential for replication of most viruses. For poxviruses, the process is divided into two stages: removal of the envelope allowing early gene expression, and breaching of the core wall allowing DNA release, replication and late gene expression. Subsequent studies showed that the host proteasome and the viral D5 protein, which has an essential role in DNA replication, are required for vaccinia virus (VACV) genome uncoating. In a search for additional VACV uncoating proteins, we noted a report that described a defect in DNA replication and late expression when the gene encoding a 68 kDa ankyrin-repeat/F box protein (68k-ank), associated with the cellular SCF ubiquitin ligase complex, was deleted from the attenuated modified vaccinia virus Ankara (MVA)...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29330711/boosting-tendon-repair-interplay-of-cells-growth-factors-and-scaffold-free-and-gel-based-carriers
#15
REVIEW
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G Pfeifer, Denitsa Docheva
BACKGROUND: Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers. Surgical treatment includes suture or transplantation of autograft, allograft or xenograft, and these serve as the most common technique for rescuing tendon injuries...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29330464/eltrombopag-versus-romiplostim-in-treatment-of-children-with-persistent-or-chronic-immune-thrombocytopenia-a-systematic-review-incorporating-an-indirect-comparison-meta-analysis
#16
Jiaxing Zhang, Yi Liang, Yuan Ai, Xiaosi Li, Juan Xie, Youping Li, Wenyi Zheng, Rui He
In absence of direct comparison, we conducted an indirect-comparison meta-analysis to evaluate the efficacy and safety of thrombopoietin-receptor agonists(TPO-RAs) in treatment of pediatric persistent or chronic immune thrombocytopenia(ITP). PubMed, Embase, Cochrane Library, Clinical Trials.gov, China National Knowledge Infrastructure, and Chinese Biomedical Literature Database were searched from their earliest records to May 2017. Randomized controlled trials comparing the TPO-RAs with placebo in pediatric ITP were included...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318581/prostanoids-for-critical-limb-ischaemia
#17
REVIEW
Valeria Vietto, Juan Va Franco, Victoria Saenz, Denise Cytryn, Jose Chas, Agustín Ciapponi
BACKGROUND: Peripheral arterial occlusive disease (PAOD) is a common cause of morbidity and mortality due to cardiovascular disease in the general population. Although numerous treatments have been adopted for patients at different disease stages, no option other than amputation is available for patients presenting with critical limb ischaemia (CLI) unsuitable for rescue or reconstructive intervention. In this regard, prostanoids have been proposed as a therapeutic alternative, with the aim of increasing blood supply to the limb with occluded arteries through their vasodilatory, antithrombotic, and anti-inflammatory effects...
January 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29311004/use-of-a-parabolic-microphone-to-detect-hidden-subjects-in-search-and-rescue
#18
Nathaniel L Bowditch, Stanley K Searing, Jeffrey A Thomas, Peggy K Thompson, Jacqueline N Tubis, Sylvia P Bowditch
INTRODUCTION: This study compares a parabolic microphone to unaided hearing in detecting and comprehending hidden callers at ranges of 322 to 2510 m. METHODS: Eight subjects were placed 322 to 2510 m away from a central listening point. The subjects were concealed, and their calling volume was calibrated. In random order, subjects were asked to call the name of a state for 5 minutes. Listeners with parabolic microphones and others with unaided hearing recorded the direction of the call (detection) and name of the state (comprehension)...
January 5, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29275086/a-game-theory-approach-for-assessing-risk-value-and-deploying-search-and-rescue-resources-after-devastating-tsunamis
#19
Cheng-Kuang Wu
The current early-warning system and tsunami protection measures tend to fall short because they always underestimate the level of destruction, and it is difficult to predict the level of damage by a devastating tsunami on uncertain targets. As we know, the key to minimizing the total number of fatalities after a disaster is the deployment of search and rescue efforts in the first few hours. However, the resources available to the affected districts for emergency response may be limited. This study proposes two game theoretic models that are designed for search-and-rescue resource allocation...
December 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/29245999/long-non-coding-rnas-for-osteosarcoma-in-the-mouse-a-meta-analysis
#20
Shaopu Hu, Junli Chang, Yimian Li, Wenyi Wang, Edward C Zou, Mengyao Guo, Qi Shi, Yongjun Wang, Yanping Yang
Osteosarcoma, one of the most common primary bone malignances, is a leading cause of cancer death among children and adolescents. Recently, growing studies have found that long non-coding RNAs (lncRNAs) can interfere with the expression of various genes, and participate in the occurrence and development of malignancies. The purpose of this study is to evaluate the potential functions of lncRNAs as diagnostic biomarkers and therapeutic targets for osteosarcoma in mice, thus to direct the strict design for the future preclinical experiments and clinical trials...
November 21, 2017: Oncotarget
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