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https://www.readbyqxmd.com/read/28522250/ppargamma-agonists-rescue-increased-phosphorylation-of-fgf14-at-s226-in-the-tg2576-mouse-model-of-alzheimer-s-disease
#1
Wei-Chun J Hsu, Norelle Wildburger, Sigmund J Haidacher, Miroslav N Nenov, Oluwarotimi Folorunso, Aditya K Singh, Brent C Chesson, Whitney F Franklin, Ibdanelo Cortez, Rovshan G Sadygov, Kelly T Dineley, Jai Rudra, Giulio Taglialatela, Cheryl F Lichti, Larry Denner, Fernanda Laezza
BACKGROUND: Cognitive impairment in humans with Alzheimer's disease (AD) and in animal models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARγ) agonists, such as rosiglitazone (RSG). Previously, we demonstrated that in the Tg2576 animal model of AD, RSG treatment rescued cognitive deficits and reduced aberrant activity of granule neurons in the dentate gyrus (DG), an area critical for memory formation...
May 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28516471/topical-non-steroidal-anti-inflammatory-drugs-for-analgesia-in-traumatic-corneal-abrasions
#2
REVIEW
Abel Wakai, John G Lawrenson, Annali L Lawrenson, Yongjun Wang, Michael D Brown, Michael Quirke, Omar Ghandour, Ryan McCormick, Cathal D Walsh, Ahmed Amayem, Eddy Lang, Nick Harrison
BACKGROUND: Traumatic corneal abrasions are relatively common and there is a lack of consensus about analgesia in their management. It is therefore important to document the clinical efficacy and safety profile of topical ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs) in the management of traumatic corneal abrasions. OBJECTIVES: To identify and evaluate all randomised controlled trials (RCTs) comparing the use of topical NSAIDs with placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions (including corneal abrasions arising from foreign body removal), to reduce pain, and its effects on healing time...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28499685/ultrasound-in-the-royal-danish-air-force-search-and-rescue-helicopter-2-case-reports
#3
René Christian Bleeg
No abstract text is available yet for this article.
May 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28496395/a-relative-quantitative-positive-negative-ion-switching-method-for-untargeted-lipidomics-via-high-resolution-lc-ms-ms-from-any-biological-source
#4
Susanne B Breitkopf, Stéphane J H Ricoult, Min Yuan, Ying Xu, David A Peake, Brendan D Manning, John M Asara
INTRODUCTION: Advances in high-resolution mass spectrometry have created renewed interest for studying global lipid biochemistry in disease and biological systems. OBJECTIVES: Here, we present an untargeted 30 min. LC-MS/MS platform that utilizes positive/negative polarity switching to perform unbiased data dependent acquisitions (DDA) via higher energy collisional dissociation (HCD) fragmentation to profile more than 1000-1500 lipid ions mainly from methyl-tert-butyl ether (MTBE) or chloroform:methanol extractions...
March 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28482883/rescue-medication-use-as-a-patient-reported-outcome-in-copd-a-systematic-review-and-regression-analysis
#5
Yogesh Suresh Punekar, Sheetal Sharma, Ankit Pahwa, Jitender Takyar, Ian Naya, Paul W Jones
BACKGROUND: Reducing rescue medication use is a guideline-defined goal of asthma treatment, however, little is known about the validity of rescue medicine use as a marker of symptoms in chronic obstructive pulmonary disease (COPD). To improve patient outcomes, greater insight is needed into the relationship between rescue medication use and alternative COPD outcomes. METHODS: A systematic search of electronic databases (Embase®, MEDLINE® and Cochrane CENTRAL) was conducted from database start to 26 May, 2015...
May 8, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28481285/a-novel-real-time-reference-key-frame-scan-matching-method
#6
Haytham Mohamed, Adel Moussa, Mohamed Elhabiby, Naser El-Sheimy, Abu Sesay
Unmanned aerial vehicles represent an effective technology for indoor search and rescue operations. Typically, most indoor missions' environments would be unknown, unstructured, and/or dynamic. Navigation of UAVs in such environments is addressed by simultaneous localization and mapping approach using either local or global approaches. Both approaches suffer from accumulated errors and high processing time due to the iterative nature of the scan matching method. Moreover, point-to-point scan matching is prone to outlier association processes...
May 7, 2017: Sensors
https://www.readbyqxmd.com/read/28473200/thermal-desorption-comprehensive-two-dimensional-gas-chromatography-coupled-to-variable-energy-electron-ionization-time-of-flight-mass-spectrometry-for-monitoring-subtle-changes-in-volatile-organic-compound-profiles-of-human-blood
#7
Lena M Dubois, Katelynn A Perrault, Pierre-Hugues Stefanuto, Stefan Koschinski, Matthew Edwards, Laura McGregor, Jean-François Focant
Blood is a matrix with high potential for forensic investigations and human rescue. Its volatile signature can be used in search exercises to locate injured or deceased individuals. Little is known, however, about the volatile organic compound (VOC) profile of blood, except that it is complex and varies while blood ages. In the present study, we used thermal desorption (TD) and comprehensive two-dimensional gas chromatography (GCxGC) coupled to variable-energy electron ionization time-of-flight mass spectrometry (TOFMS) to monitor VOC signatures of human blood...
April 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28470851/effectiveness-of-curcuminoids-in-the-treatment-of-knee-osteoarthritis-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#8
Igho J Onakpoya, Elizabeth A Spencer, Rafael Perera, Carl J Heneghan
AIM: To critically appraise and evaluate the evidence for effectiveness of curcuminoids in the treatment of osteoarthritis (OA) in adults. METHODS: We conducted electronic searches in Medline, Embase, AMED, Cinahl and the Cochrane library. We included randomized controlled trials (RCTs) that investigated the effectiveness of orally-administered curcuminoids in OA in adults, and assessed risk of bias using the Cochrane risk of bias criteria. We used a random-effect model for meta-analysis...
May 4, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28468386/non-line-of-sight-tracking-of-people-at-long-range
#9
Susan Chan, Ryan E Warburton, Genevieve Gariepy, Jonathan Leach, Daniele Faccio
A remote-sensing system that can determine the position of hidden objects has applications in many critical real-life scenarios, such as search and rescue missions and safe autonomous driving. Previous work has shown the ability to range and image objects hidden from the direct line of sight, employing advanced optical imaging technologies aimed at small objects at short range. In this work we demonstrate a long-range tracking system based on single laser illumination and single-pixel single-photon detection...
May 1, 2017: Optics Express
https://www.readbyqxmd.com/read/28467434/a-concept-for-optimizing-avalanche-rescue-strategies-using-a-monte-carlo-simulation-approach
#10
Ingrid Reiweger, Manuel Genswein, Peter Paal, Jürg Schweizer
Recent technical and strategical developments have increased the survival chances for avalanche victims. Still hundreds of people, primarily recreationists, get caught and buried by snow avalanches every year. About 100 die each year in the European Alps-and many more worldwide. Refining concepts for avalanche rescue means to optimize the procedures such that the survival chances are maximized in order to save the greatest possible number of lives. Avalanche rescue includes several parameters related to terrain, natural hazards, the people affected by the event, the rescuers, and the applied search and rescue equipment...
2017: PloS One
https://www.readbyqxmd.com/read/28455583/neurotoxicity-after-high-dose-methotrexate-mtx-is-adequately-explained-by-insufficient-folinic-acid-rescue
#11
REVIEW
Ian Joseph Cohen
PURPOSE: To challenge the view that the dose of folinic acid rescue after high-dose methotrexate (MTX) has no significance in the prevention of neurotoxicity and to present the minority view that neurotoxicity can be prevented by an adequate dose of folinic acid, without compromising treatment results. Several fallacies that led to the misunderstanding of post MTX neurotoxicity are presented. METHODS: Data mining using search engines was used to find relevant publications, and an e-mail survey of more than 60 authors of articles in this field was performed...
April 28, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28431195/feeding-behavior-and-activity-budget-of-the-southern-yellow-cheeked-crested-gibbons-nomascus-gabriellae-in-a-lowland-tropical-forest
#12
Thanh H Bach, Jin Chen, Minh D Hoang, Kingsly C Beng, Van T Nguyen
The southern yellow-cheeked crested gibbon (Nomascus gabriellae), an endangered species native to Vietnam and Cambodia, lives exclusively in undisturbed tropical forests and depends primarily on ripe fruit for food. Although this species is highly threatened, its ecology and conservation status remain relatively unknown. In order to understand how this heavily frugivorous primate adapts to the seasonal fluctuation of fruit resources in the forest, we collected feeding behavior and ranging activity data on one group of southern yellow-cheeked crested gibbons in Cat Tien National Park, Vietnam, over 1-year period...
April 21, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28428030/complement-inhibition-with-eculizumab-for-thrombotic-microangiopathy-rescues-a-living-donor-kidney-transplant-in-a-patient-with-antiphospholipid-antibody-syndrome
#13
Praveen Ramakrishnan Geethakumari, Patrick Mille, Rakesh Gulati, Srikanth Nagalla
Antiphospholipid antibody syndrome (APS) is an enigmatic heterogeneous disorder despite several revelations in its pathobiology. Renal transplantation in patients with APS has been notoriously difficult due to the high risk of development of thrombotic microangiopathy (TMA), which is often refractory to conventional treatment modalities such as aggressive anticoagulation and plasmapheresis. We describe a case of a 58-year-old male with secondary APS undergoing living unrelated renal transplantation for end-stage renal disease from lupus nephritis...
March 10, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28425829/effects-of-dexmedetomidine-versus-midazolam-for-premedication-in-paediatric-anaesthesia-with-sevoflurane-a-meta-analysis
#14
Ji-Feng Feng, Xiao-Xia Wang, Yan-Yan Lu, Deng-Ge Pang, Wei Peng, Jian-Lan Mo
Background Dexmedetomidine (DEX), an α2-adrenergic receptor agonist, produces ideal sedation and early postoperative recovery for premedication in paediatric surgery, reducing preoperative anxiety and facilitating smooth induction of anaesthesia. We performed a meta-analysis to compare the effects of DEX and midazolam (MDZ) in paediatric anaesthesia with sevoflurane. Methods PubMed, Ovid, Web of Science, and Public Health Management Corporation were searched through December 2016 for randomized controlled trials (RCTs) that compared DEX and MDZ in children undergoing sevoflurane anaesthesia...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28413270/the-effect-of-perioperative-esmolol-on-early-postoperative-pain-a-systematic-review-and-meta-analysis
#15
REVIEW
Richard Watts, Venkatesan Thiruvenkatarajan, Marni Calvert, Graeme Newcombe, Roelof M van Wijk
Esmolol has been shown to improve postoperative pain and reduce opioid requirements. The aim of this systematic review was to evaluate the effect of perioperative esmolol as an adjunct on early postoperative pain intensity, recovery profile, and anesthetic requirement. Databases were searched for randomized placebo-controlled trials evaluating the effects of esmolol during general anesthesia. Primary outcomes were related to early postoperative pain whereas secondary outcomes were related to emergence time, postoperative nausea and vomiting, and intraoperative anesthetic requirement...
January 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28409393/stereotactic-radiosurgery-vs-fractionated-radiotherapy-for-tumor-control-in-vestibular-schwannoma-patients-a-systematic-review
#16
REVIEW
Oscar Persson, Jiri Bartek, Netanel Ben Shalom, Theresa Wangerid, Asgeir Store Jakola, Petter Förander
OBJECTIVE: Repeated controlled studies have revealed that stereotactic radiosurgery is better than microsurgery for patients with vestibular schwannoma (VS) <3 cm in need of intervention. In this systematic review we aimed to compare results from single-fraction stereotactic radiosurgery (SRS) to fractionated stereotactic radiotherapy (FSRT) for patients with VS. DATA SOURCES AND ELIGIBILITY CRITERIA: We systematically searched MEDLINE, Web of Science, Embase and Cochrane and screened relevant articles for references...
June 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28407197/autologous-hematopoietic-stem-cell-transplantation-following-high-dose-chemotherapy-for-nonrhabdomyosarcoma-soft-tissue-sarcomas
#17
REVIEW
Frank Peinemann, Heike Enk, Lesley A Smith
BACKGROUND: Soft tissue sarcomas (STS) are a highly heterogeneous group of rare malignant solid tumors. Nonrhabdomyosarcoma soft tissue sarcomas (NRSTS) comprise all STS except rhabdomyosarcoma. In people with advanced local or metastatic disease, autologous hematopoietic stem cell transplantation (HSCT) applied after high-dose chemotherapy (HDCT) is a planned rescue therapy for HDCT-related severe hematologic toxicity. The rationale for this update is to determine whether any randomized controlled trials (RCTs) have been conducted and to clarify whether HDCT followed by autologous HSCT has a survival advantage...
April 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28394263/elevating-expression-of-mecp2-t158m-rescues-dna-binding-and-rett-syndrome-like-phenotypes
#18
Janine M Lamonica, Deborah Y Kwon, Darren Goffin, Polina Fenik, Brian S Johnson, Yue Cui, Hengyi Guo, Sigrid Veasey, Zhaolan Zhou
Mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome (RTT), a neurological disorder affecting cognitive development, respiration, and motor function. Genetic restoration of MeCP2 expression reverses RTT-like phenotypes in mice, highlighting the need to search for therapeutic approaches. Here, we have developed knockin mice recapitulating the most common RTT-associated missense mutation, MeCP2 T158M. We found that the T158M mutation impaired MECP2 binding to methylated DNA and destabilized MeCP2 protein in an age-dependent manner, leading to the development of RTT-like phenotypes in these mice...
May 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28390222/recovery-of-deceased-scuba-divers-from-within-flooded-subterranean-caves
#19
Peter Buzzacott, Craig Nelson, Ken Hill, Lamar Hires
Each year in the US three divers, on average, perish inside flooded caves and their remains require recovery. Recovery is a hazardous undertaking often performed by members of the International Underwater Cave Rescue and Recovery (IUCRR) team, in collaboration with local law enforcement and medical examiners/coroners. Since forming in 1999 the IUCRR have established standard recovery procedures for cave diving fatalities. This article reviews each stage of the recovery; the call out, arrival on site, the search, recording/preserving the evidence, the recovery, the handover and post-recovery record-keeping...
March 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28383425/ropivacaine-versus-levobupivacaine-in-peripheral-nerve-block-a-prisma-compliant-meta-analysis-of-randomized-controlled-trials
#20
COMPARATIVE STUDY
Ang Li, Zhijian Wei, Yang Liu, Jiaxiao Shi, Han Ding, Haoshuai Tang, Pengyuan Zheng, Yanzheng Gao, Shiqing Feng
BACKGROUND: To determine which is more potent in peripheral nerve block between ropivacaine and levobupivacaine. METHODS: A literature search was performed in the EMBASE, Medline, the Cochrane Library, and the Web of Science. The trials that were found were then evaluated for eligibility. The Cochrane Collaboration's Review Manager software was used to perform the meta-analyses. RESULTS: Twelve studies including 556 patients were included for final analysis...
April 2017: Medicine (Baltimore)
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