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https://www.readbyqxmd.com/read/28434061/the-sources-of-calcium-for-noradrenaline-induced-contraction-in-the-human-thoracic-internal-artery
#1
Leszek Buzun, Beata Modzelewska, Anna Kostrzewska, Ewa Kleszczewska, Tomasz Kleszczewski
The aim of the present study was to examine the contribution of intracellular and extracellular calcium sources in contraction caused by noradrenaline (NA) of the human internal thoracic artery (ITA) in vitro. Distal segments of ITA were obtained from 20 patients (aged 38-73, at the time of routine coronary artery surgical revascularization (CABG)). Contractile responses to 10(-6) mol/L NA in the physiological salt solution and in Ca(2+)-free solution without and after incubation with 10(-6) mol/L thapsigargin (TSG) were recorded under isometric conditions...
April 22, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28429762/annealing-induced-re-crystallization-in-ch3nh3pbi3-xclx-for-high-performance-perovskite-solar-cells
#2
Yingguo Yang, Shanglei Feng, Meng Li, Weidong Xu, Guangzhi Yin, Zhaokui Wang, Baoquan Sun, Xingyu Gao
Using poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as hole conductor, a series of inverted planar CH3NH3PbI3-xClx perovskite solar cells (PSCs) were fabricated based on perovskite annealed by an improved time-temperature dependent (TTD) procedure in a flowing nitrogen atmosphere for different time. Only after an optimum annealing time, an optimized power conversion efficiency of 14.36% could be achieved. To understand their performance dependence on annealing time, an in situ real-time synchrotron-based grazing incidence X-ray diffraction (GIXRD) was used to monitor a step-by-step gradual structure transformation from distinct mainly organic-inorganic hybrid materials into highly ordered CH3NH3PbI3 crystal during annealing...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28426936/cholesterol-assisted-bacterial-cell-surface-engineering-for-photodynamic-inactivation-of-gram-positive-and-gram-negative-bacteria
#3
Hao-Ran Jia, Ya-Xuan Zhu, Zhan Chen, Fu-Gen Wu
Antibacterial photodynamic therapy (PDT) which enables effective killing of regular and multidrug-resistant (MDR) bacteria is a promising treatment modality for bacterial infection. However, because most photosensitizer (PS) molecules fail to strongly interact with the surface of Gram-negative bacteria, this technique is only suitable for treating Gram-positive bacterial infection, which largely hampers its practical applications. Herein, we revealed for the first time that cholesterol could significantly facilitate the hydrophobic binding of PSs to the bacterial surface, achieving the hydrophobic interaction-based bacterial cell surface engineering that could effectively photo-inactivate both Gram-negative and Gram-positive bacteria...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28425533/impact-of-lipid-composition-and-photosensitizer-hydrophobicity-on-the-efficiency-of-light-triggered-liposomal-release
#4
Julien Massiot, Ali Makky, Florent Di Meo, David Chapron, Patrick Trouillas, Véronique Rosilio
Photo-triggerable liposomes are considered nowadays as promising drug delivery devices due to their potential to release encapsulated drugs in a spatial and temporal manner. In this work, we have investigated the photopermeation efficiency of three photosensitizers (PSs), namely verteporfin, pheophorbide a and m-THPP when incorporated into liposomes with well-defined lipid compositions (SOPC, DOPC or SLPC). By changing the nature of phospholipids and PSs, the illumination of the studied systems was shown to significantly alter their lipid bilayer properties via the formation of lipid peroxides...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28424927/development-of-new-extra-glandular-manifestations-or-associated-auto-immune-diseases-after-establishing-the-diagnosis-of-primary-sj%C3%A3-gren-s-syndrome-a-long-term-study-of-the-antonius-nieuwegein-sj%C3%A3-gren-ans-cohort
#5
E J Ter Borg, J C Kelder
To investigate in a long-term study, the development of new extra-glandular manifestations (EGM) or associated auto-immune diseases (AID) from 1 year after establishing the diagnosis of primary Sjögren's syndrome (pSS). The primary goal was to examine the frequency and type of these manifestations and to find out which demographic, clinical and serological profile was most at risk. All outpatients diagnosed with primary Sjögren's syndrome were included in a retrospective study, with at least one check-up per year, from June 1991 until August 2015...
April 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28422829/impact-of-pain-on-cognitive-functions-in-primary-sj%C3%A3-gren-syndrome-with-small-fiber-neuropathy-10-cases-and-a-literature-review
#6
Sandrine Indart, Jacques Hugon, Pierre Jean Guillausseau, Alice Gilbert, Julien Dumurgier, Claire Paquet, Damien Sène
Primary Sjögren syndrome (pSS) is a chronic systemic autoimmune disease characterized by xerophthalmia, xerostomia, and potential peripheral or central neurological involvement. In pSS, the prevalence of cognitive disorders is generally sparse across literature and the impact of pain on cognitive profile is unclear. The aim of this study was to determine the relation between pain, cognitive complaint, and impairment in a very homogenous population of 10 pSS patients with painful small fiber neuropathy (PSFN) and spontaneous cognitive complaint...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421999/use-and-withdrawal-of-immunosuppressors-in-primary-sj%C3%A3-gren-s-syndrome
#7
Jiram Torres-Ruiz, David Faz-Muñoz, Nora Hernández-Díaz, Gabriela Hernandez-Molina
OBJECTIVES: To assess the use and causes of withdrawal of glucocorticoids and immunosuppressors among patients with primary Sjögren's syndrome (pSS) in the clinical setting. METHODS: We retrospectively reviewed the medical records of 155 pSS patients and registered demographics, glandular/extraglandular features, serological data, cumulative ESSDAI and SSDDI. A single rheumatologist attributed the indication and cause of withdrawal of glucocorticoids and immunosuppressors...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28421993/increased-expression-of-interferon-%C3%AE-in-minor-salivary-glands-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-and-its-synergic-effect-with-interferon-%C3%AE-on-salivary-gland-epithelial-cells
#8
You-Jung Ha, Yong Seok Choi, Eun Ha Kang, Jin-Haeng Chung, Seunghee Cha, Yeong Wook Song, Yun Jong Lee
OBJECTIVES: To investigate the expressions of interferon (IFN)-λs and their receptor, IL28RA, in minor salivary glands (MSG) of pSS patients and their effects on the salivary gland cells. METHODS: The expressions of IFN-λs and IL28RA were evaluated in MSG by immunohistochemistry in 15 patients with pSS and in 5 patients with non-SS sicca. Poly(I:C)-induced IL-28A and IL-29 expressions were determined in immortalized human salivary gland acinar (NS-SV-AC) and ductal (NS-SV-DC) cell lines...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28420481/safety-and-feasibility-of-subcutaneous-purse-string-suture-of-the-femoral-vein-after-electrophysiological-procedures-on-uninterrupted-oral-anticoagulation
#9
Marc Kottmaier, Felix Bourier, Tilko Reents, Alina Reiter, Marielouise Kornmayer, Verena Semmler, Martha Telishevska, Katharina Koch-Büttner, Michael Deiss, Stephanie Brooks, Christian Grebmer, Carsten Lennerz, Christoph Kolb, Gabriele Hessling, Isabel Deisenhofer
The aim of this study was to compare safety and feasibility of a subcutaneous purse-string suture (PSS) with manual compression (MC) to gain hemostasis in patients after multiple femoral venous punctures undergoing electrophysiological procedures on uninterrupted oral anticoagulation (OAK). A total of 784 patients who underwent catheter ablation for atrial fibrillation (n = 564) or (a)typical atrial flutter (n = 220) were assessed. Four hundred sixty-two patients received PSS (58.9%) and 322 patients (41...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28420055/perceived-stress-and-reported-cognitive-symptoms-among-georgia-patients-with-systemic-lupus-erythematosus
#10
L Plantinga, S S Lim, C B Bowling, C Drenkard
Objective To examine associations of perceived stress with cognitive symptoms among adults with systemic lupus erythematosus (SLE). Methods Among 777 adult (≥18 years) SLE patients, the association of Perceived Stress Scale (PSS) scores with two self-reported cognitive symptoms was examined: forgetfulness (severe/moderate vs. mild/none; from the Systemic Lupus Activity Questionnaire) and difficulty concentrating (all/most vs. some/little/none of the time; from the Lupus Impact Tracker). The study used multivariable logistic regression to estimate the odds ratios (ORs) per minimal important difference (MID = 0...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28416279/the-impact-of-work-life-balance-on-intention-to-stay-in-academia-results-from-a-national-survey-of-pharmacy-faculty
#11
Tristan Lindfelt, Eric J Ip, Alejandra Gomez, Mitchell J Barnett
PURPOSE: Border-Crossing theory suggests work-life balance and career satisfaction are inter-related and disappointment in work-life balance may predict changes in one's career path. Application of this theory to health profession faculty is plausible but has not been fully explored. The purpose of this study is to examine factors related to reported career change intention among United States pharmacy school faculty and to determine if Border-Crossing theory fits these observations. METHODS: Results from a national web-based survey administered via Qualtrics(®) to American Association of Colleges of Pharmacy (AACP) members were utilized...
April 13, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28415674/primary-sj%C3%A3-gren-s-syndrome-with-diffuse-cystic-lung-changes-developed-systemic-lupus-erythematosus-a-case-report-and-literature-review
#12
Xiao Liu, Hao Li, Yunhong Yin, Dedong Ma, Yiqing Qu
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease that can occur as a unique existence (primary Sjögren's syndrome) or merge with other systemic diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis or systemic sclerosis (secondary Sjögren's syndrome). Data on the two diseases occurrence order are inadequate. Primary Sjögren's syndrome (pSS) may relatively uncommonly lead to diffuse cystic lung changes. We represent a female who was diagnosed pSS with diffuse cystic lung alterations developed SLE two years later...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412958/supporting-parents-in-taking-care-of-their-infants-admitted-to-a-neonatal-intensive-care-unit-a-prospective-cohort-pilot-study
#13
Giuseppe De Bernardo, Maria Svelto, Maurizio Giordano, Desiree Sordino, Marina Riccitelli
BACKGROUND: Family-Centred Care (FCC) is recognized as an important component of all paediatric care, including neonatal care, although practical clinical guidelines to support this care model are still needed in Italy. The characteristics and services for families in Italian NICUs show a lack of organization and participation. METHODS: The first aim was to compare satisfaction and stress levels in two groups of parents: an FCC group and a non-FCC group (NFCC). The second aim was to evaluate body weight gain in the newborns enrolled...
April 17, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28410675/the-relationship-between-epileptiform-discharges-and-background-activity-in-the-visual-analysis-of-electroencephalographic-examinations-in-dogs-with-seizures-of-different-etiologies
#14
M Wrzosek, J R Ives, M Karczewski, E Dziadkowiak, E Gruszka
Electroencephalographic (EEG) recordings in 125 outpatient dogs with various epileptiform encephalopathies were acquired under medetomidine sedation using subdermal wire electrodes. The features of canine EEG (background activity [BGA] and epileptiform discharges [EDs]) were assessed, described and compared. The dogs included neurologically healthy controls (N, n = 19), dogs with portosystemic shunt (PSS, n = 9), dogs with intracranial pathologies (IP, n = 27) and dogs with idiopathic epilepsy (IE, n = 70)...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28407597/layer-by-layer-deposition-on-a-heterogeneous-surface-effect-of-sorption-kinetics-on-the-growth-of-polyelectrolyte-multilayers
#15
Hervé Bellanger, Kirstin Casdorff, Livius F Muff, Rebecca Ammann, Ingo Burgert, Benjamin Michen
Surface functionalization by means of controlled deposition of charged polymers or nanoparticles using the layer-by-layer (LbL) approach has been used to modify mostly engineered materials with well-defined surface chemistry and morphology. In this regard, natural and inhomogeneous interfaces have gained very little attention. Furthermore, natural substrates are susceptible to alterations by factors commonly used to control the growth of multilayers, such as pH, temperature and ionic strength. Here, we study the impact of sorption kinetics of a bilayer system (Poly(diallyldimethylammonium chloride) (PDDA) and Poly(sodium 4-styrenesulfonate) (PSS)) on a natural heterogeneous wood surface at neutral pH, without salt addition, on the multilayer buildup...
February 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28407494/vaccine-nanocarriers-coupling-intracellular-pathways-and-cellular-biodistribution-to-control-cd4-vs-cd8-t-cell-responses
#16
Marcela Rincon-Restrepo, Aaron Mayer, Sylvie Hauert, Daniel K Bonner, Edward A Phelps, Jeffrey A Hubbell, Melody A Swartz, Sachiko Hirosue
Nanoparticle delivery systems are known to enhance the immune response to soluble antigens (Ags) and are thus a promising tool for the development of new vaccines. Our laboratory has engineered two different nanoparticulate systems in which Ag is either encapsulated within the core of polymersomes (PSs) or decorated onto the surface of nanoparticles (NPs). Previous studies showed that PSs are better at enhancing CD4 T cells and antibody titers, while NPs preferentially augment cytotoxic CD8 T cells. Herein, we demonstrate that the differential activation of T cell immunity reflects differences in the modes of intracellular trafficking and distinct biodistribution of the Ag in lymphoid organs, which are both driven by the properties of each nanocarrier...
March 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/28404907/investigation-of-three-potential-autoantibodies-in-sjogren-s-syndrome-and-associated-malt-lymphoma
#17
Li Cui, Naseim Elzakra, Shuaimei Xu, Gary Guishan Xiao, Yan Yang, Shen Hu
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease which might progress to mucosal-associated lymphoid tissue lymphoma (pSS/MALT). Diagnosis of pSS requires an invasive tissue biopsy and a delay in diagnosis of pSS has been frequently reported. In this study, four proteins including cofilin-1, alpha-enolase, annexin A2 and Rho GDP-dissociation inhibitor 2 (RGI2) were found to be over-expressed in pSS and pSS/MALT by 2D gel electrophoresis/mass spectrometry, and the finding was verified by the microarray analysis and western blotting results...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402373/depletion-and-double-layer-forces-acting-between-charged-particles-in-solutions-of-like-charged-polyelectrolytes-and-monovalent-salts
#18
Mohsen Moazzami-Gudarzi, Plinio Maroni, Michal Borkovec, Gregor Trefalt
Interaction forces between silica particles were measured in aqueous solutions of the sodium salt of poly(styrene sulphonate) (PSS) and NaCl using the colloidal probe technique based on an atomic force microscope (AFM). The observed forces can be rationalized through a superposition of damped oscillatory forces and double layer forces quantitatively. The double layer forces are modeled using Poisson-Boltzmann (PB) theory for a mixture of a monovalent symmetric electrolyte and a highly asymmetric electrolyte, whereby the multivalent coions represent the polyelectrolyte chains...
April 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28399842/deficits-of-perceived-spatial-separation-induced-prepulse-inhibition-in-patients-with-schizophrenia-relationships-to-symptoms-and-neurocognition
#19
Ning-Bo Yang, Qing Tian, Yu Fan, Qi-Jing Bo, Liang Zhang, Liang Li, Chuan-Yue Wang
BACKGROUND: Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings about the relationship between PPI and clinical symptoms, cognitive performances have been equivocal. METHODS: Seventy-five schizophrenia patients (SZ) and 50 healthy controls (HC) were assessed in a modified acoustic PPI paradigm, named perceived spatial separation-induced PPI (PSS-PPI), compared to perceived spatial co-location PPI (PSC-PPI) with inter-stimulus interval (ISI) of 120 ms...
April 11, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28399831/characteristics-of-cases-needing-advanced-treatment-for-intractable-posner-schlossman-syndrome
#20
Kazuichi Maruyama, Yuko Maruyama, Sunao Sugita, Kazuhiko Mori, Yu Yokoyama, Shiho Sanuki-Kunimatsu, Hiroko Nakagawa, Shigeru Kinoshita, Manabu Mochizuki, Toru Nakazawa
BACKGROUND: In Posner-Schlossman syndrome (PSS), which is characterized by recurrent unilateral attacks of ocular hypertension. Surgical treatment is sometimes necessary because intraocular pressure (IOP) cannot be controlled with anti-glaucoma medications. To identify the clinical features of Posner-Schlossman syndrome (PSS) indicative of the need for intraocular pressure (IOP)-controlling surgery. METHODS: This study was a retrospective case-series analysis of the clinical charts of 33 patients diagnosed with PSS, who underwent surgery to control IOP or received medication only...
April 11, 2017: BMC Ophthalmology
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