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Jie Gao, Jun Li, Wen-Chao Geng, Fang-Yuan Chen, Xingchen Duan, Zhe Zheng, Dan Ding, Dong-Sheng Guo
Activatable phototheranostics is highly appealing to meet the demand of precision medicine. However, although displaying the efficacy in construction of activatable photosensitizers (PSs), direct covalent decoration still shows some inevitable issues, such as complex molecular design, tedious synthesis, possible photoactivity changes and potential toxicity. Herein, we propose a novel concept of biomarker displacement activation (BDA) using host-guest strategy. To exemplify BDA, we engineered a PS-loaded nanocarrier by utilizing a macrocyclic amphiphile, where the fluorescence and photoactivity of PS were completely annihilated by the complexation of macrocyclic receptor (OFF state)...
March 21, 2018: Journal of the American Chemical Society
Kristopher D Kelly, Hadi M Fares, Samir Abou Shaheen, Joseph B Schlenoff
Polyelectrolyte multilayers (PEMUs) are ultrathin membranes made by alternating adsorption of oppositely charged polyelectrolytes on substrates. Although PEMUs have shown exceptional selectivity for certain ion-filtering applications, they usually contain an excess of one of the polyelectrolytes due to the history- and condition-dependent mode of PEMU assembly. This excess charge provides fixed sites for ion exchange, enhancing the concentration of oppositely charged ions. Thus, the ion-permselective properties of PEMUs cannot be compared unless they are assembled under identical conditions...
March 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Fahad D Alosaimi, Hossam S Alawad, Ayedh K Alamri, Abdullah I Saeed, Khalid A Aljuaydi, Alwaleed S Alotaibi, Khalid M Alotaibi, Eiad A Alfaris
Background: Physicians experience several work-related stressors that have been mounting up in recent decades. This study aimed to examine perceived stress and its risk factors and consequences among consultant physicians in Saudi Arabia. Methods: A cross-sectional study was conducted from November 2014 to March 2015 among physicians who were assigned rank of consultant. The stress level was assessed using perceived stress scale (PSS). Results: A total of 582 consultants participated...
2018: Advances in Medical Education and Practice
Daimei Sasayama, Shinya Asano, Shun Nogawa, Shoko Takahashi, Kenji Saito, Hiroshi Kunugi
Photic sneeze syndrome (PSS) is characterized by a tendency to sneeze when the eye is exposed to bright light. Recent genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) associated with PSS in Caucasian populations. We performed a GWAS on PSS in Japanese individuals who responded to a web-based survey and provided saliva samples. After quality control, genotype data of 210,086 SNPs in 11,409 individuals were analyzed. The overall prevalence of PSS was 3.2%. Consistent with previous reports, SNPs at 3p12...
March 20, 2018: Journal of Human Genetics
Peisheng Liang, Wangyong Zhu, Tianjun Lan, Qian Tao
Saliva secretion disorder is one of the most common symptoms in primary Sjögren syndrome (pSS). Salivary biomarkers related to saliva secretion disorder were identified in a pSS murine model, NOD/ShiLtJ mouse, using differential proteomic analysis. Candidate biomarkers were screened with Kyoto Encyclopedia of Genes and Genomes pathway analysis and validated in saliva and salivary glands by western blotting and immunohistochemistry (IHC). Biological functions were detected using ingenuity pathway analysis (IPA)...
March 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
Katarzyna J Błochowiak, Dorota Trzybulska, Anna Olewicz-Gawlik, Jan J Sikora, Michalina Nowak-Gabryel, Jarosław Kocięcki, Henryk Witmanowski, Jerzy Sokalski
BACKGROUND: Aberrant angiogenesis plays a role in the pathogenesis of Sjögren's syndrome (SS). OBJECTIVES: The aim of this study was to compare the levels of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) in stimulatory parotid saliva and in serum in healthy subjects (HS), patients with primary SS (pSS) and secondary SS (sSS) and to evaluate the expression of EGF, proangiogenic VEGF165 and antiangiogenic VEGF165 b mRNA isoforms. Additionally, we determined the salivary levels of serine/arginine splicing factor (SRSF1), which regulates VEGF165 and VEGF165 b expression...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mónica Fernandez Castro, Carlos Sánchez-Piedra, Jose Luis Andreu, Víctor Martínez Taboada, Alejandro Olivé, Jose Rosas
INTRODUCTION: Primary Sjögren's syndrome (pSS) is an autoimmune disease, characterized by lymphocytic infiltration of exocrine glands and other organs, resulting in dry eye, dry mouth and extraglandular systemic findings. OBJECTIVE: To explore the association of severe or very severe dry eye with extraocular involvement in patients diagnosed with primary Sjögren's syndrome. METHODS: SJOGRENSER registry is a multicenter cross-sectional study of pSS patients...
March 20, 2018: Rheumatology International
Yujia You, Xiaolong Liang, Tinghui Yin, Min Chen, Chen Qiu, Chuang Gao, Xiaoyou Wang, Yongjiang Mao, Enze Qu, Zhifei Dai, Rongqin Zheng
Photodynamic therapy (PDT) holds promise for focal therapy of prostate cancer (PCa). However, the therapeutic efficacy needs improvement, and further development of PDT for PCa has challenges, including uncertainty of photosensitizers (PSs) accumulation at the tumor site and difficulty in visualizing lesions using conventional ultrasound (US) imaging. We have developed novel porphyrin-grafted lipid (PGL) microbubbles (MBs; PGL-MBs) and propose a strategy to integrate PGL-MBs with US imaging to address these limitations and enhance PDT efficacy...
2018: Theranostics
Keiko Aota, Koichi Kani, Tomoko Yamanoi, Koh-Ichi Nakashiro, Naozumi Ishimaru, Masayuki Azuma
CXCL10, a CXC chemokine induced by interferon-gamma [IFN-γ], has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. Although CXCL10 is known to be overexpressed in the salivary glands of individuals with primary Sjögren's syndrome (pSS), it is unclear which cells produce CXCL10 under what types of stimulations. Here, we investigated the precise molecular mechanisms by which CXCL10 was produced in human salivary gland ductal (NS-SV-DC) and acinar (NS-SV-AC) cell lines...
March 17, 2018: Inflammation
Won Seon Koh, Jeong Eun Kim, Young Suck Ro, Joo Yeon Ko
BACKGROUND: Despite various treatments attempts, no prospective studies have compared the different therapeutic modalities for treatment of idiopathic guttate hypomelanosis (IGH). This study aimed to compare the efficacy of CO2 fractional laser (CO₂FL), Er:YAG fractional laser (EYFL), and 0.025% topical tretinoin for treating IGH. MATERIALS AND METHODS: A total of 122 lesions were analyzed from 18 patients (mean age, 70.00 ± 20.00 years). Treatment outcome evaluations included the visual analog scale (VAS) to assess lesion severity, investigator's global assessment (IGA) to assess the extent of improvement, and patient's satisfaction score (PSS)...
March 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Paola Cipriani, Francesco Ciccia, Giuliana Guggino, Francesco Carubbi, Vasiliki Liakouli, Paola Di Benedetto, Giovanni Triolo, Roberto Giacomelli, Piero Ruscittia, Onorina Berardicurti
BACKGROUND: A close relationship between rheumatic diseases and cardiovascular disease (CVD) has been reported, accounting for the higher mortality and morbidity observed in these patients. In the last years, it has been clearly reported that patients affected by primary Sjögren's syndrome (pSS) experienced an increased risk of CVD. OBJECTIVE: This review aimed at investigating CVD, traditional cardiovascular (CV) risk factors and possible targeted therapeutic strategies in pSS patients...
March 15, 2018: Reviews on Recent Clinical Trials
Qinjun Sun, Shaolong Zhou, Xiaolei Shi, Xiaochun Wang, Liyan Gao, Zhanfeng Li, Yuying Hao
CuO nanowires (NWs) with the diameters ranging from 130 to 275 nm have been successfully prepared by electrospinning and calcination technique, followed by a calcination process. Inverted planar heterojunction perovskite solar cells (PSCs) with the structure of ITO/CuO NWs/PEDOT:PSS/CH3NH3PbI3/PCBM/Bphen/Ag were designed, achieving a best power conversion efficiency (PCE) of 16.87% , which is 21% improvement compared with that of the control PSCs without CuO NWs. By the characterizations of optical microscope, X-ray diffraction (XRD) and scanning electron microscopy (SEM), it is found that CuO NWs have uniform morphology and orderly arrangement...
March 15, 2018: ACS Applied Materials & Interfaces
Santosh Kumar Mandal, Pulukool Sandhya, Jayakanthan Kabeerdoss, Janardana Ramya, Gowri Mahasampath, Debashish Danda
Human and animal model studies suggest CXCL13 is a potential biomarker in primary Sjögren's syndrome (pSS). CXCL13 has not been studied in Indian patients with pSS. pSS cases classified by American European Consensus Group (AECG) or American college of Rheumatology(ACR) 2012 criteria, attending rheumatology clinic between July 2014 and July 2015 were included. Hospital staff and healthy, non-blood related family members of patients constituted the control group. pSS cases underwent clinical evaluation, laboratory investigations, ESSDAI and ESSPRI scoring...
March 14, 2018: Rheumatology International
Susana Algarvio, Isabel Leal, João Maroco
The aim of this study was to validate the Parental Stress Scale (PSS) for Portuguese parents and to further investigate the scale's criterion-related validity. A two-stage stratified sample of the Portuguese population of parents, with children attending public preschools and primary schools, was obtained, totalizing 3842 parents of children between 3 and 10 years old. Parents completed a Parental Concerns Scale and the Portuguese version of the PSS. Results support the four-factor structure of the Portuguese version of the PSS...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
Valter R Fonseca, Vasco C Romão, Ana Agua-Doce, João Eurico Fonseca, Luis Graca
We are excited to find that most of our conclusions (1) were replicated in an independent larger primary Sjögren's syndrome (pSS) cohort, as reported by Verstappen et al in their Letter (Verstappen G et al, Arthritis & Rheumatology, in press). Indeed, our colleagues were also able to demonstrate that the ratio of blood T follicular regulatory (Tfr) / T follicular helper (Tfh) cells were increased in pSS patients, and specifically within pSS patients with focus score (FS) ≥ 1, supporting its discriminative value for the diagnosis of pSS...
March 13, 2018: Arthritis & Rheumatology
Pengli Li, Jiejie Hao, Haihua Li, Huashi Guan, Chunxia Li
OBJECTIVES: Propylene glycol alginate sodium sulfate (PSS) is poorly absorbed by oral administration due to its large molecular weight and slightly degradability in stomach acidic environment. Here, a novel enteric-coated nano formulation of PSS (enteric PSS-NP) was prepared to improve its bioavailability and efficacy. METHODS: The enteric PSS-NP was prepared by double (W1 /O/W2 ) emulsion and solvent evaporation method. The drug release characteristics in vitro were studied in artificial gastrointestinal fluid...
March 12, 2018: Journal of Pharmacy and Pharmacology
Yue Yang, Long Chen, Yuan Jia, Yang Liu, Lei Wen, Yaoxian Liang, Yuan An, Shi Chen, Yin Su, Zhanguo Li
To analyze the clinical spectrum, laboratory characteristics, and outcomes of monoclonal gammopathy (MG) in patients with rheumatic diseases. Screening for the presence of MG was performed in 872 inpatients with rheumatic diseases from January 2010 to July 2017. A total of 41 patients were enrolled. Their clinical and biological features in addition to outcomes were described. For each patient with primary Sjögren syndrome (pSS), 2 age- and sex-matched pSS patients without MG were selected as controls. Risk factors for the presence of MG and malignant hematological neoplasias were assessed...
March 13, 2018: Clinical Rheumatology
Gabriel Maciel, Luisa Servioli, Carlotta Nannini, Alvise Berti, Cynthia S Crowson, Sara J Achenbach, Eric L Matteson, Divi Cornec
Objective: To determine rates and primary discharge diagnoses of hospitalisation in a cohort of patients with incident primary Sjögren's syndrome (pSS) compared with the general population. Methods: This was a retrospective population-based cohort study focused on Olmsted County, Minnesota. The pSS cohort consisted of patients with incident pSS in the 1976-2015 period and was compared with a cohort of individuals without pSS matched 3:1 for age, sex and calendar year, randomly selected from the same population...
2018: RMD Open
S Geyl, J Jacques, S Parreau, A Cypierre, T Tabouret, G Gondran, K H Ly, E Liozon, F X Lapébie, H Bezanahary, S Palat, J Monteil, V Loustaud-Ratti, A L Fauchais
INTRODUCTION: Upper digestive symptoms may be present in up to 50% of patients with primary Sjögren syndrome (pSS). We report a retrospective cohort of gastroparesis in a population of pSS presenting unexplained dyspepsia. Delayed gastric emptying was defined by a gastric emptying time above 113min or by a retention percentage at 4h more than 10% on scintigraphy. RESULTS: Eleven patients with primary Sjögren syndrome and gastroparesis were included in a retrospective study...
March 8, 2018: La Revue de Médecine Interne
Naoki Tomii, Masatoshi Yamazaki, Tatsuhiko Arafune, Kaichiro Kamiya, Kazuo Nakazawa, Haruo Honjo, Nitaro Shibata, Ichiro Sakuma
BACKGROUND: The action mechanism of stimulation toward spiral waves (SWs) owing to the complex excitation patterns that occur just after point stimulation has not yet been experimentally clarified. OBJECTIVE: This study sought to test our hypothesis that the effect of capturing excitable gap of SW by stimulation can also be explained as the interaction of original phase singularity (PS) and PSs induced by the stimulation on the wave tail (WT) of the original SW...
March 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
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