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https://www.readbyqxmd.com/read/28230203/water-insoluble-photosensitizer-nanocolloids-stabilized-by-supramolecular-interfacial-assembly-towards-photodynamic-therapy
#1
Yamei Liu, Kai Ma, Tifeng Jiao, Ruirui Xing, Guizhi Shen, Xuehai Yan
Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6)...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28227920/in-vitro-evaluation-of-the-long-term-stability-of-pedot-pss-coated-microelectrodes-for-chronic-recording-and-electrical-stimulation-of-neurons
#2
A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang, A Schander, T Tesmann, S Strokov, H Stemmann, A K Kreiter, W Lang, A K Kreiter, W Lang, A Schander, H Stemmann, S Strokov
For the chronic application of neural prostheses long-term stable microelectrodes for electrical stimulation are essential. In recent years many developments were done to investigate different appropriate materials for these electrodes. One of these materials is the electrical conductive polymer PEDOT, which has low impedance and high charge injection capacity. However, the long-term stability of this polymer is still unclear. Thus this paper reports on the in-vitro evaluation of the long-term stability of PEDOT coated gold microelectrodes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227899/peripheral-sensory-stimulation-is-neuroprotective-in-a-rat-photothrombotic-ischemic-stroke-model
#3
Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor, Aishwarya Bandla, Chua Le Teng Sherry, Frances Lim, Chan Kim Chuan, Lun-De Liao, Nitish V Thakor, Lun-De Liao, Nitish V Thakor, Frances Lim, Chua Le Teng Sherry, Aishwarya Bandla, Chan Kim Chuan
Ischemic stroke is one of the leading causes of death and disability in the world. Thrombolytic therapy using recombinant tissue plasminogen activator (rtPA), the only FDA-approved drug for acute ischemia, is limited by a narrow therapeutic time window and risk of hemorrhage. There is a serious need for a neuroprotective therapy which is clinically viable. We earlier demonstrated that peripheral sensory stimulation (PSS) is a potential therapeutic intervention for hyperacute ischemia resulting in recovery of neurovascular functions when administered immediately following ischemia onset in a rat model...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227497/a-wireless-system-with-stimulation-and-recording-capabilities-for-interfacing-peripheral-nerves-in-rodents
#4
P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang, P Schonle, F Michoud, N Brun, A Guex, S P Lacour, Q Wang, Q Huang, N Brun, A Guex, P Schonle, Q Huang, Q Wang, S P Lacour, F Michoud
Considerable progress has been made in the last decade in implantable bioelectronic neurosystems. Yet most neural implants are used in acute and tethered experimental conditions. Here, we present a preliminary prototype of a multichannel system for simultaneous peripheral nerve stimulation and neural recording. The system comprises miniaturized electronics with a total volume of less then 1.4cm(3) including a 3.7V battery which is expected to last for 94 days of standby operation or 18 hours of continuous recording and stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227393/an-integrated-neuroprotective-intervention-for-brain-ischemia-validated-by-ecog-fpam
#5
Yu-Hang Liu, Lun-De Liao, Su Jing Chan, Aishwarya Bandla, Nitish V Thakor, Yu-Hang Liu, Lun-De Liao, Su Jing Chan, Aishwarya Bandla, Nitish V Thakor, Yu-Hang Liu, Aishwarya Bandla, Nitish V Thakor, Su Jing Chan, Lun De Liao
Brain ischemia is a neurological deficit caused by a reduction in the blood supply to tissue, and one of the leading causes of disability in the world. Currently, the most well-known therapeutic agent for ischemia recovery is recombinant tissue plasminogen activator (rtPA), but it is viable for only a small portion (approximately 3.6%) of ischemic patients and may cause side effects such as tissue damage. Thus, introducing a new therapeutic concept for ischemia, we proposed an integrated intervention combining global and focal stimulations in this article...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225371/measurement-of-perceived-stress-in-age-related-macular-degeneration
#6
Bradley E Dougherty, San-San L Cooley, Frederick H Davidorf
PURPOSE: To validate the Perceived Stress Scale (PSS) in patients with age-related macular degeneration (AMD) using Rasch analysis. METHODS: Study participants with AMD were recruited from the retina service of the Department of Ophthalmology at the Ohio State University during clinical visits for treatment or observation. Visual acuity with habitual distance correction was assessed. A 10-item version of the PSS was administered in large print or by reading the items to the patient...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28224798/ultralight-graphene-foam-conductive-polymer-composites-for-exceptional-electromagnetic-interference-shielding
#7
Ying Wu, Zhenyu Wang, Xu Liu, Xi Shen, Qingbin Zheng, Quan Xue, Jang-Kyo Kim
Ultralight, high-performance electromagnetic interference (EMI) shielding graphene foam (GF)/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) composites are developed by drop coating of PEDOT:PSS on cellular-structured, freestanding GFs. To enhance the wettability and the interfacial bonds with PEDOT:PSS, GFs are functionalized with 4-dodecylbenzenesulfonic acid. The GF/PEDOT:PSS composites possess an ultralow density of 18.2×10(-3) g/cm(3) and a high porosity of 98.8%, as well as an enhanced electrical conductivity by almost four folds from 11...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28219419/emotional-intelligence-perceived-stress-and-academic-performance-of-sri-lankan-medical-undergraduates
#8
P Ranasinghe, W S Wathurapatha, Y Mathangasinghe, G Ponnamperuma
BACKGROUND: Previous research has shown that higher Emotional Intelligence (EI) is associated with better academic and work performance. The present study intended to explore the relationship between EI, perceived stress and academic performance and associated factors among medical undergraduates. METHODS: This descriptive cross-sectional research study was conducted among 471 medical undergraduates of 2nd, 4th and final years of University of Colombo, Sri Lanka...
February 20, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28218693/propylene%C3%A2-glycol%C3%A2-alginate%C3%A2-sodium%C3%A2-sulfate%C3%A2-alleviates%C3%A2-cerulein-induced%C3%A2-acute%C3%A2-pancreatitis%C3%A2-by%C3%A2-modulating%C3%A2-the%C3%A2-mek-erk%C3%A2-pathway%C3%A2-in%C3%A2-mice
#9
Hui Zhang, Yueyue Li, Linqiang Li, Hua Liu, Liangkai Hu, Ying Dai, Jianqing Chen, Shuqi Xu, Weimin Chen, Xiaorong Xu, Xuanfu Xu
Previous studies have focused on the effects of propylene glycol alginate sodium sulfate  (PSS)  against  thrombosis,  but  the  anti-inflammatory  potential  is  unknown.  Therefore,  we  specifically focused on the protective effects of PSS on cerulein-induced acute pancreatitis (AP)  using a mouse model, and investigated the mechanism of PSS on autophagy and apoptosis via the  Mitogen-activated  protein  kinase  (MEK)/extracellular  signal-regulated  kinase  (ERK)  pathway...
February 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28218518/one-step-interface-engineering-for-all-inkjet-printed-all-organic-components-in-transparent-flexible-transistors-and-inverters-polymer-binding
#10
Jewook Ha, Seungjun Chung, Mingyuan Pei, Kilwon Cho, Hoichang Yang, Yongtaek Hong
We report a one-step interface engineering methodology, which can be used on both polymer electrodes and gate dielectric for all-inkjet-printed, flexible, transparent organic thin-film transistors (OTFTs) and inverters. Dimethylchlorosilane-terminated polystyrene (PS) was introduced as a surface modifier to cured poly(4-vinyl phenol) dielectric and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) electrodes without any pretreatment. On the untreated and PS interlayer-treated dielectric/electrode surfaces, 6,13-bis(triisopropylsilylethynyl)pentacene was printed to fabricate OTFTs and inverters...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28217953/b7-h4-deficiency-in-salivary-gland-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-impairs-the-regulatory-effect-on-t-cells
#11
Xiaomei Li, Daliang Yu, Ning Yu, Ximei Wang, Xiangpei Li, David C H Harris, Yiping Wang
AIM: Our previous study confirmed the defect of B7-H4 expression in peripheral blood and salivary glands of patients with primary Sjögren's syndrome (pSS). The aim of this study was to analyze the effect of the deficit expression of B7-H4 on CD4(+) T cells. METHODS: CD4(+) T cells were purified by magnetic-activated cell sorting MACS. The proliferation and cytokine production of CD4(+) T cells co-cultured with purified salivary gland epithelial cells (SGECs) from pSS or non-SS sicca syndrome were detected...
February 20, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28217226/functional-characteristics-of-left-ventricular-synchronization-via-right-ventricular-outflow-tract-pacing-detected-by-two-dimensional-strain-echocardiography
#12
Yasutaka Hirayama, Yuichiro Kawamura, Nobuyuki Sato, Tatsuya Saito, Hideichi Tanaka, Yasuaki Saijo, Kenjiro Kikuchi, Katsumi Ohori, Naoyuki Hasebe
BACKGROUND: Recently, due to the detrimental effects on the ventricular function associated with right ventricular apical (RVA) pacing, right ventricular septal (RVS) pacing has become the preferred pacing method. However, the term RVS pacing refers to both right ventricular outflow-tract (RVOT) and mid-septal (RVMS) pacing, leading to a misinterpretation of the results of clinical studies. The purpose of this study, therefore, was to elucidate the functional differences of RVA, RVOT, and RVMS pacing in patients with atrioventricular block...
February 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28211671/organic-solar-cells-based-on-wo2-72-nanowire-anode-buffer-layer-with-enhanced-power-conversion-efficiency-and-ambient-stability
#13
Longzhen You, Bin Liu, Tao Liu, Bingbing Fan, Yunhao Cai, Lin Guo, Yanming Sun
Tungsten oxide as an alternative to conventional acidic PEDOT:PSS has attracted much attention in organic solar cells (OSCs). However, the vacuum-processed WO3 layer and high temperature sol-gel hydrolyzed WOX are incompatible with large-scale manufacturing of OSCs. Here, we report for the first time that a specific tungsten oxide WO2.72 (W18O49) nanowire can function well as the anode buffer layer. The nw-WO2.72 film exhibits a high optical transparency. The power conversion efficiency (PCE) of OSCs based on three typical polymer active layers PTB7:PC71BM, PTB7-Th:PC71BM, and PDBT-T1:PC71BM with nw-WO2...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28210632/increased-interleukin-17f-is-associated-with-elevated-autoantibody-levels-and-more-clinically-relevant-than-interleukin-17a-in-primary-sj%C3%A3-gren-s-syndrome
#14
Yuzhou Gan, Xiaozhen Zhao, Jing He, Xu Liu, Yun Li, Xiaolin Sun, Zhanguo Li
Th17 related immune response is pathogenic in primary Sjögren's syndrome (pSS). However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined. We recruited one hundred and nine pSS patients and forty-two healthy controls and their serum levels of IL-17A and IL-17F were determined by multiplex cytokine assays. White blood cell, red blood cell, neutrophil, lymphocyte, IgM, IgG, C3, C4, RF, ANA, anti-SSA antibody, and anti-SSB antibody were measured by standard laboratory techniques...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28208783/influence-of-weak-base-addition-to-hole-collecting-buffer-layers-in-polymer-fullerene-solar-cells
#15
Jooyeok Seo, Soohyeong Park, Myeonghun Song, Jaehoon Jeong, Chulyeon Lee, Hwajeong Kim, Youngkyoo Kim
We report the effect of weak base addition to acidic polymer hole-collecting layers in normal-type polymer:fullerene solar cells. Varying amounts of the weak base aniline (AN) were added to solutions of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The acidity of the aniline-added PEDOT:PSS solutions gradually decreased from pH = 1.74 (AN = 0 mol% ) to pH = 4.24 (AN = 1.8 mol %). The electrical conductivity of the PEDOT:PSS-AN films did not change much with the pH value, while the ratio of conductivity between out-of-plane and in-plane directions was dependent on the pH of solutions...
February 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28205561/the-selective-flow-of-volatile-organic-compounds-in-conductive-polymer-coated-microchannels
#16
Faramarz Hossein-Babaei, Ali Hooshyar Zare
Many gaseous markers of critical biological, physicochemical, or industrial occurrences are masked by the cross-sensitivity of the sensors to the other active components present at higher concentrations. Here, we report the strongly selective diffusion and drift of contaminant molecules in air-filled conductive polymer-coated microfluidic channels for the first time. Monitoring the passage of different target molecules through microchannels coated with Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) revealed that contaminants such as hexane, benzene, and CO pass through the channel unaffected by the coating while methanol, ethanol, and partly acetone are blocked...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197771/granulomatous-interstitial-nephritis-associated-with-primary-sj%C3%A3-gren-s-syndrome
#17
B Bitik, I I Gonul, S Haznedaroglu, B Goker, A Tufan
Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by lymphocytic and plasmacytic infiltration of the exocrine glands. Tubulointerstitial nephritis (TIN) is the most common type of renal involvement in pSS. However, clinically significant renal involvement is uncommon. Granulomatous interstitial nephritis (GIN) is a rare histopathological entity characterized by the presence of granulomas against a background of interstitial inflammation. GIN is not a typical and commonly seen form of TIN in pSS...
February 14, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28197568/interfacial-electronic-structures-revealed-at-the-rubrene-ch3nh3pbi3-interface
#18
Gengwu Ji, Guanhaojie Zheng, Bin Zhao, Fei Song, Xiaonan Zhang, Kongchao Shen, Yingguo Yang, Yimin Xiong, Xingyu Gao, Liang Cao, Dong-Chen Qi
The electronic structures of rubrene films deposited on CH3NH3PbI3 perovskite have been investigated using in situ ultraviolet photoelectron spectroscopy (UPS) and X-ray photoelectron spectroscopy (XPS). It was found that rubrene molecules interacted weakly with the perovskite substrate. Due to charge redistribution at their interface, a downward 'band bending'-like energy shift of ∼0.3 eV and an upward band bending of ∼0.1 eV were identified at the upper rubrene side and the CH3NH3PbI3 substrate side, respectively...
February 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28194968/pedot-pss-as-solid-contact-for-ion-selective-electrodes-the-influence-of-the-pedot-pss-film-thickness-on-the-equilibration-times
#19
Marcin Guzinski, Jennifer Marie Jarvis, Felio Perez, Bradford D Pendley, Erno Lindner, Roland de Marco, Gaston A Crespo, Robert G Acres, Raymart Walker, Josiah Luke Bishop
To understand the rate determining processes during the equilibration of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate-based (PEDOT(PSS)-based) solid contact (SC) ion-selective electrodes (ISEs), the surfaces of Pt, Au, and GC electrodes were coated with 0.1, 1.0, 2.0 and 4.0μm thick galvanostatically deposited PEDOT(PSS) films. Next, potential vs. time transients were recorded with these electrodes, with and without an additional potassium ion-selective membrane (ISM) coating, following their first contact with 0...
February 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28194679/soil-properties-and-microbial-ecology-of-a-paddy-field-after-repeated-applications-of-domestic-and-industrial-sewage-sludges
#20
Xiaoyan Liu, Wuxing Liu, Qingling Wang, Longhua Wu, Yongming Luo, Peter Christie
The effects of repeated application of two types of sewage sludge, domestic and industrial (petrochemical, PSS) sludges, into paddy fields over a 5-year period on the soil properties and microbial ecology were studied and compared with conventional NPK fertilizer application. Soil organic matter and total nitrogen contents were significantly higher in the two sludge treatments than that in fertilized plots after 5 years. Soil concentrations of potentially toxic metals were low after 5 years of both sludge treatments, but the polycyclic aromatic hydrocarbons (PAHs) showed differences between the two sludge types...
February 14, 2017: Environmental Science and Pollution Research International
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