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https://www.readbyqxmd.com/read/28627569/porphyrin-based-photosensitizers-and-their-dna-conjugates-for-singlet-oxygen-induced-nucleic-acid-interstrand-crosslinking
#1
Eva M Llamas, João P C Tome, João M M Rodrigues, Tomás Torres, Annemieke Madder
The development of methods for the generation of site-selective interstrand crosslinks (ICLs) in synthetic oligonucleotides provides a platform for the study of ICL repair mechanisms and the stabilisation of DNA-based materials. Our group has previously reported on the use of a furan moiety as a masked reactive functionality for ICL generation and recently introduced the use of (1)O2 as an efficient light-induced oxidant. Here, the use of porphyrin-based photosensitizers (PSs) has been explored for ICL generation...
June 19, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28627420/distinct-neural-processes-support-post-success-and-post-error-slowing-in-the-stop-signal-task
#2
Yihe Zhang, Jaime S Ide, Sheng Zhang, Sien Hu, Nikola S Valchev, Xiaoying Tang, Chiang-Shan R Li
Executive control requires behavioral adaptation to environmental contingencies. In the stop signal task (SST), participants exhibit slower go trial reaction time (RT) following a stop trial, whether or not they successfully interrupt the motor response. In previous fMRI studies, we demonstrated activation of the right-hemispheric ventrolateral prefrontal cortex, in the area of inferior frontal gyrus, pars opercularis (IFGpo) and anterior insula (AI), during post-error slowing (PES). However, in similar analyses we were not able to identify regional activities during post-success slowing (PSS)...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28627220/the-german-version-of-the-perceived-stress-scale-pss-10-evaluation-of-dimensionality-validity-and-measurement-invariance-with-exploratory-and-confirmatory-bifactor-modeling
#3
Dorota Reis, Dirk Lehr, Elena Heber, David Daniel Ebert
The Perceived Stress Scale (PSS) is a popular instrument for measuring the degree to which individuals appraise situations in their lives as excessively uncontrollable and overloaded. Despite its widespread use (e.g., for evaluating intervention effects in stress management studies), there is still no agreement on its factor structure. Hence, the aim of the present study was to examine the dimensionality, measurement invariance (i.e., across gender, samples, and time), reliability, and validity of the PSS. Data from 11,939 German adults (73% women) were used to establish an exploratory bifactor model for the PSS with one general and two specific factors and to cross-validate this model in a confirmatory bifactor model...
June 1, 2017: Assessment
https://www.readbyqxmd.com/read/28626202/stent-fracture-and-peri-stent-contrast-staining-after-everolimus-eluting-stent-implantation%C3%A3-5-year-outcomes
#4
Katsuya Miura, Takeshi Tada, Akinune Kuwayama, Takenobu Shimada, Masanobu Ohya, Hidewo Amano, Shunsuke Kubo, Yusuke Hyodo, Suguru Otsuru, Seiji Habara, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota
BACKGROUND: Stent fracture (SF) and peri-stent contrast staining (PSS) after sirolimus-eluting stent implantation are reported to be risk factors of adverse events. However, the effect of these after everolimus-eluting stent (EES) implantation on long-term outcomes remains unclear.Methods and Results:The study sample comprised 636 patients (1,081 lesions) undergoing EES implantation in 2010 and follow-up angiography within 1 year. The 5-year cumulative rates of target lesion revascularization (TLR) and major adverse cardiac events (MACE: a combination of all-cause death, myocardial infarction, and TLR) were compared between patients with and without SF or PSS...
June 13, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28622456/elevated-ccl25-and-ccr9-expressing-t-helper-cells-in-salivary-glands-of-primary-sj%C3%A3-gren-s-syndrome-patients-potential-new-axis-in-lymphoid-neogenesis
#5
Sofie L M Blokland, Maarten R Hillen, Aike A Kruize, Stephan Meller, Bernhard Homey, Glennda M Smithson, Timothy R D J Radstake, Joel A G van Roon
Introduction T follicular helper (Tfh)-cells play a critical role in germinal center formation and B-cell activation, both hallmarks of primary Sjögren's syndrome (pSS). CCR9-expressing Th-cells have "Tfh-like" characteristics and are increased at mucosa-associated sites in several inflammatory conditions. Because of their unique characteristics and limited evaluation we investigated the local and systemic CCL25/CCR9-axis in pSS. Methods CCL25 protein and mRNA levels and CCR9+ Th-cells were assessed in labial salivary glands (LSG) of pSS and non-Sjögren's sicca (nSS) patients and their correlation with inflammatory and clinical parameters was evaluated...
June 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28621922/selective-organic-contacts-for-methyl-ammonium-lead-iodide-mapi-perovskite-solar-cells-influence-of-layer-thickness-on-carriers-extraction-and-carriers-lifetime
#6
Ilario Gelmetti, Lydia Cabau, Núria F Montcada, Emilio Palomares
We have fabricated MAPI solar cells using as selective contacts PEDOT:PSS polymer for holes and PCBM-C70 fullerene derivative for electrons. The thickness of MAPI, PCBM-C70, and PEDOT:PSS layers has been varied in order to evaluate the contribution of each layer to the final device performance. We have measured the devices capacitance under illumination and the charge carrier's lifetime using photoinduced time-resolved techniques. The results show that in this kind of devices the limiting layer is the PCBM-C70 due to its relative reduced mobility compared to PEDOT:PSS that makes the control of the fullerene thickness crucial for device optimization...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28621288/photodvnamic-therapy-in-endodontics
#7
Zahed Mohammadi, Hamid Jafarzadeh, Sousan Shalavi, Jun-Ichiro Kinoshita
Commonly used irrigants do not always eradicate the entire microbial flora in infected root canals. Therefore, several other strategies, such as photodynamic therapy (PDT) have been developed. Photoactivated disinfection is based on the interaction of a photosensitive antibacterial agent and a light source. It uses a nontoxic dye named photosensitizer (PS) and low-intensity visible light. In oxygen presentation, these combine to produce some cytotoxic species. The PS molecules attach to bacteria membrane. Irradiation with a specific wavelength of the light may lead to the production of singlet oxygen, resulting in rupture of the microbial cell wall...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28621153/depression-in-primary-sj%C3%A3-gren-s-syndrome-a-systematic-review-and-meta-analysis
#8
Yafei Cui, Lin Li, Rulan Yin, Qian Zhao, Shengnan Chen, Qiuxiang Zhang, Biyu Shen
There is substantial uncertainty regarding the prevalence of depression in Primary Sjögren's syndrome (pSS). We conducted a systematic review aiming to evaluate the association of pSS with depression. PubMed, Web of Science, VIP, CNKI and Wanfang database were searched to find the published literatures (from these databases established to October 2016). Studies were screened according to inclusion and exclusion criteria and the qualities of included studies were evaluated. The data was analyzed using Revman5...
June 16, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28619542/development-of-a-multidisciplinary-program-to-expedite-care-of-esophageal-emergencies
#9
DuyKhanh P Ceppa, Carlo Maria Rosati, Lola Chabtini, Samantha M Stokes, Holly C Cook, Karen M Rieger, Thomas J Birdas, John C Lappas, William R Kessler, John M DeWitt, Dean D Maglinte, Kenneth A Kesler
BACKGROUND: Level 1 programs have improved outcomes by expediting the multidisciplinary care of critically ill patients. We established a novel level 1 program for the management of esophageal emergencies. METHODS: After institutional review board approval, we performed a retrospective analysis of patients referred to our level 1 esophageal emergency program from April 2013 through November 2015. A historical comparison group of patients treated for the same diagnosis in the previous 2 years was used...
June 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28616908/-the-correlation-between-micrornas-in-serum-and-the-extent-of-liver-injury
#10
Yi-Nan Zuo, Xue-Ling He, Xue-Ni Shi, Shi-Hang Wei, Hai-Lin Yin
OBJECTIVES: To investigate the correlation between the absolute quantification of the microRNAs (miR-122, miR-451, miR-92a, miR-192) in serum during acute liver injury and the extent of liver injury on rat models of CCl4 induced acute liver injury and mice models of acetaminophen (APAP) induced acute liver injury. Furthermore, to investigate the correlation between the absolute quantification of microRNAs in serum and the drug induced liver injury pathological scoring system (DILI-PSS)...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28616388/unusual-haemodynamics-in-two-dogs-and-two-cats-with-portosystemic-shunt-implications-for-distinguishing-between-congenital-and-acquired-conditions
#11
Mario Ricciardi
Extrahepatic porto-systemic shunt (PSS) in small animals can be congenital (CPSS) or acquired (APSS) as a consequence of portal hypertension (PH), and are distinguished on the bases of their anatomical pattern. A precise morphologic imaging assessment, along with clinical and histopathologic findings, is important for distinguishing patients with PH from those with congenital PSSs, which require different therapeutic approach. Expected findings in patients with PH are presence of ascites, multiple APSS, and a confirmed cause of portal flow obstruction...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28612224/extrahepatic-portal-venous-obstruction-what-should-be-the-mainstay-of-treatment
#12
Richa Lal, Moinak Sen Sarma, Manish K Gupta
The two cornerstones of management for Extrahepatic portal vein obstruction (EHPVO) are endotherapy and surgery [Porto-systemic shunts (PSS)/Mesorex bypass (MRB)]. Endotherapy is the mainstay of treatment for acute variceal bleed control and has also been used extensively for secondary prophylaxis till variceal eradication is achieved. However, long-term follow-up beyond endoscopic eradication of esophageal varices (EEEV) indicates that there are numerous delayed bleed and non bleed sequelae of EHPVO, which merit surgery as a definitive procedure to decompress the hypertensive portal venous system...
June 14, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28610655/the-diagnosis-and-treatment-of-sj%C3%A3-gren-s-syndrome
#13
Ana-Luisa Stefanski, Christian Tomiak, Uwe Pleyer, Thomas Dietrich, Gerd Rüdiger Burmester, Thomas Dörner
BACKGROUND: Sjögren's syndrome is one of the more common inflammatory rheumatological diseases, with a prevalence of at least 0.4% in Germany. METHODS: This review is based on pertinent articles retrieved by a selective search in PubMed. Special attention is drawn to updated classification criteria and current treatment recommendations. RESULTS: Sjögren's syndrome has a wide variety of presentations, ranging from the local involvement of exocrine glands with keratoconjunctivitis sicca and xerostomia (the leading signs of the disease) to the systemic, extraglandular involvement of multiple organs...
May 26, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28608797/bioactive-mushroom-polysaccharides-a-review-on-monosaccharide-composition-biosynthesis-and-regulation
#14
REVIEW
Qiong Wang, Feng Wang, Zhenghong Xu, Zhongyang Ding
Mushrooms are widely distributed around the world and are heavily consumed because of their nutritional value and medicinal properties. Polysaccharides (PSs) are an important component of mushrooms, a major factor in their bioactive properties, and have been intensively studied during the past two decades. Monosaccharide composition/combinations are important determinants of PS bioactivities. This review summarizes: (i) monosaccharide composition/combinations in various mushroom PSs, and their relationships with PS bioactivities; (ii) possible biosynthetic pathways of mushroom PSs and effects of key enzymes on monosaccharide composition; (iii) regulation strategies in PS biosynthesis, and prospects for controllable biosynthesis of PSs with enhanced bioactivities...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28603961/high-performance-ultrathin-organic-inorganic-hybrid-silicon-solar-cells-via-solution-processed-interface-modification
#15
Jie Zhang, Yinan Zhang, Tao Song, Xinlei Shen, Xuegong Yu, Shuit-Tong Lee, Baoquan Sun, Baohua Jia
Organic-inorganic hybrid solar cells based on n-type crystalline silicon and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) exhibited promising efficiency along with a low-cost fabrication process. In this work, ultrathin flexible silicon substrates, with a thickness as low as tens of micrometers, were employed to fabricate hybrid solar cells to reduce the use of silicon materials. To improve the light-trapping ability, nanostructures were built on the thin silicon substrates by a metal-assisted chemical etching method (MACE)...
June 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28603955/enhanced-crystalline-phase-purity-of-ch3nh3pbi3-xclx-film-for-high-efficiency-hysteresis-free-perovskite-solar-cells
#16
Yingguo Yang, Shanglei Feng, Weidong Xu, Meng Li, Li Li, Xingmin Zhang, Gengwu Ji, Xiaonan Zhang, Zhao-Kui Wang, Yimin Xiong, Liang Cao, Baoquan Sun, Xingyu Gao
Despite of rapid successful developments towards promising perovskite solar cells (PSCs) efficiency, they often suffer significant hysteresis effects. Using synchrotron-based grazing incidence X-ray diffraction (GIXRD) with different probing depths by varying the incident angle, we found that the perovskite films consist of dual phases with a parent phase dominant in the interior and a child phase with a smaller (110) inter-planar space (d(110)) after rapid thermal annealing (RTA) which is a widely used post-treatment to improve the crystallization of solution processed perovskite films for high-performance planar PSCs...
June 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28603562/meditation-in-stressed-older-adults-improvements-in-self-rated-mental-health-not-paralleled-by-improvements-in-cognitive-function-or-physiological-measures
#17
Barry S Oken, Helané Wahbeh, Elena Goodrich, Daniel Klee, Tabatha Memmott, Meghan Miller, Rongwei Fu
To determine if mindfulness meditation (MM) in older adults improves cognition and, secondarily, if MM improves mental health and physiology, 134 at least mildly stressed 50-85 year olds were randomized to a six-week MM intervention or a waitlist control. Outcome measures were assessed at baseline and two months later at Visit 2. The primary outcome measure was an executive function/attentional measure (flanker task). Other outcome measures included additional cognitive assessments, salivary cortisol, respiratory rate, heart rate variability, Positive and Negative Affect Schedule (PANAS), Center for Epidemiologic Studies Depression (CESD), Perceived Stress Scale (PSS), Neuroticism-Extraversion-Openness (NEO) personality traits, and SF-36 health-related quality of life...
June 2017: Mindfulness
https://www.readbyqxmd.com/read/28601574/localization-of-the-trunk-muscles-using-musculoskeletal-ultrasound-guidance-for-pedicle-screw-stimulation-during-spine-surgery
#18
Tsui-Fen Yang, Jan-Wei Chiu, Chi-Kuang Feng, Ying-Chou Hsieh, Chen-Ya Yang, Jia-Chi Wang, Kwong-Kum Liao
The precise placement of recording electrodes at the relevant myotome is mandatory while performing pedicle screw stimulation (PSS) during spine surgery; however, their placement at trunk muscles is challenging. This study aimed to determine whether ultrasound guidance is useful for trunk muscle localization for PSS during spine surgery. A retrospective clinical study was conducted from a prospective database. Eighty-four patients eligible for spine surgery were recruited. Ultrasound was used to localize the intercostal, rectus abdominis, and internal oblique and psoas muscles if pedicle screw placement was performed at T3 to L1...
June 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28599067/external-adjustment-of-unmeasured-confounders-in-a-case-control-study-of-benzodiazepine-use-and-cancer-risk
#19
L C Thygesen, A Pottegård, A K Ersbøll, S Friis, T Stürmer, J Hallas
INTRODUCTION: Previous studies have reported diverging results on the association between benzodiazepine use and cancer risk. METHODS: We investigated this association in a matched case-control study including incident cancer cases during 2002-2009 in the Danish Cancer Registry (n=94,923) and age and sex-matched (1:8) population controls (n=759,334). Long-term benzodiazepine use was defined as ≥500 defined daily doses 1-5 years prior to the index date. We implemented propensity score (PS) calibration using external information on confounders available from a survey of the Danish population...
June 9, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28598393/development-of-a-flexible-strain-sensor-based-on-pedot-pss-for-thin-film-structures
#20
Alexandra El Zein, Camille Huppé, Cédric Cochrane
The aim of this study was to develop and optimize a reproducible flexible sensor adapted to thin low-density polyethylene (LDPE) films and/or structures to enable their deformation measurements. As these deformations are suspected to be weak (less than 10%), the developed sensor needs to be particularly sensitive. Moreover, it is of prime importance that sensor integration and usability do not modify the mechanical behavior of its LDPE substrate. The literature review allowed several materials to be investigated and an elastomer/intrinsically conductive polymer PEDOT:PSS (Clevios(TM)) filled composite was selected to simultaneously combine mechanical properties and electrical conductivity...
June 9, 2017: Sensors
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