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https://www.readbyqxmd.com/read/28540353/kinetic-and-optical-properties-of-a-new-probe-for-sulfatase-activity-assay
#1
Hey Young Yoon, Jong-In Hong
A new probe for detecting sulfatase activity generated fluorescent N-methylisoindole when it was treated with sulfatase. Detailed synthetic procedures of reaction intermediates are described along with their spectral data. The Diels-Alder adduct of N-methylisoindole and N-phenylmaleimide was identified by LC-MS data. The fluorescence changes and kinetic values of the probe upon sulfatase treatment in the presence and absence of reducing agents were described. Inhibitory potency of EMATE was measured using the probe in the presence and absence of reducing agents...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28535360/posttransplant-lymphoproliferative-disorder-otolaryngological-manifestations-and-management
#2
Richard Heyes, Donald W Northfelt, David G Lott
Objective Posttransplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression and is strongly associated with Epstein-Barr virus (EBV). Otolaryngological findings tend to present early in the clinical course; therefore, disease awareness among otolaryngologists is of utmost importance. This review synthesizes the body of literature pertaining to PTLD involving the head and neck, summarizes contemporary management, and highlights areas for future research...
May 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28535115/use-of-naloxone-nasal-spray-4%C3%A2-mg-in-the-community-setting-a-survey-of-use-by-community-organizations
#3
George K Avetian, Phillip Fiuty, Silvana Mazzella, Dave Koppa, Vivian Heye, Pratibha Hebbar
OBJECTIVE: Naloxone hydrochloride, an opioid antagonist, has been approved as a concentrated 4-mg dose intranasal formulation for the emergency treatment of known or suspected opioid overdose. This new formulation is easier to use and contains a higher dose of naloxone compared with earlier, unapproved kits. A survey of first responders and community-based organizations was conducted to understand initial real-world experiences with this new formulation for opioid overdose reversal. METHODS: In August 2016, 152 US organizations known to have received units of the approved 4-mg dose/unit naloxone nasal spray (NARCAN® Nasal Spray 4 mg [NNS]; Adapt Pharma, Inc...
May 23, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28513689/proton-conduction-in-a-hydrogen-bonded-complex-of-copper-ii-bipyridine-glycoluril-nitrate
#4
Sakharam B Tayade, Vishal M Dhavale, Avinash S Kumbhar, Sreekumar Kurungot, Peter Lönnecke, Evamarie Hey-Hawkins, Bhalchandra Pujari
Bipyridine glycoluril (BPG), a urea-fused bipyridine tecton, forms a square-pyramidal secondary building unit with copper(ii) which further self-assembles to give a porous hydrogen-bonded complex. This complex displays a high proton conductivity of 4.45 × 10(-3) S cm(-1) at 90 °C and 95% relative humidity (RH). Chains consisting of coordinated water, solvent water and nitrate anions embedded in the complex are responsible for high proton conduction. The proton conduction pathway was corroborated by ab initio electronic structure calculations with molecular dynamics (MD) simulations using the Nudged Elastic Band (NEB) method...
May 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28505629/impacts-and-mitigation-of-excess-diesel-related-nox-emissions-in-11-major-vehicle-markets
#5
Susan C Anenberg, Joshua Miller, Ray Minjares, Li Du, Daven K Henze, Forrest Lacey, Christopher S Malley, Lisa Emberson, Vicente Franco, Zbigniew Klimont, Chris Heyes
Vehicle emissions contribute to fine particulate matter (PM2.5) and tropospheric ozone air pollution, affecting human health, crop yields and climate worldwide. On-road diesel vehicles produce approximately 20 per cent of global anthropogenic emissions of nitrogen oxides (NOx), which are key PM2.5 and ozone precursors. Regulated NOx emission limits in leading markets have been progressively tightened, but current diesel vehicles emit far more NOx under real-world operating conditions than during laboratory certification testing...
May 15, 2017: Nature
https://www.readbyqxmd.com/read/28499781/aplastic-anemia-and-cytotoxic-t-lymphocyte-antigen-4-haploinsufficiency-treated-with-bone-marrow-transplantation
#6
Payal Makadia, Arvind Srinath, Suneeta Madan-Khetarpal, Marianne McGuire, Elena Infante, Jing Zhang, Raymond E Felgar, Amy W Davis, Hey J Chong, Randy M Windreich
No abstract text is available yet for this article.
May 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28488085/novel-loss-of-function-mutation-in-krit1-ccm1-is-associated-with-distinctly-progressive-cerebral-and-spinal-cavernous-malformations-after-radiochemotherapy-for-intracranial-malignant-germ-cell-tumor
#7
Alexandra Russo, Marie Astrid Neu, Johanna Theruvath, Bettina Kron, Arthur Wingerter, Silla Hey-Koch, Yasemin Tanyildizi, Joerg Faber
PURPOSE: Cerebrospinal cavernous malformations (CCMs) are vascular lesions characterized by dilated and leaky capillary caverns. CCMs can cause seizures, focal neurological deficits or acute intracranial hemorrhage; however, most patients are asymptomatic. CCMs occur either sporadically or as a familial autosomal-dominant disorder. We present a clinical and molecular study of a patient with distinctive cerebral and spinal cavernous malformations following radiochemotherapy for a malignant brain tumor...
May 9, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28474880/enhanced-bioactivity-and-bacteriostasis-of-surface-fluorinated-polyetheretherketone
#8
Meiling Chen, Liping Ouyang, Tao Lu, Heying Wang, Fanhao Meng, Yan Yang, Congqin Ning, Jingzhi Ma, Xuanyong Liu
Although polyetheretherketone (PEEK) has been considered as a potential orthopedic and dental application material due to its similar elastic modulus as bones, inferior osseointegration and bacteriostasis of PEEK hampers its clinical application. In this work, fluorinated PEEK was constructed via plasma immersion ion implantation (PIII) followed by hydrofluoric acid treatment to ameliorate the osseointegration and antibacterial properties of PEEK. The surface microstructure, composition, and hydrophilicity of all samples were investigated...
May 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28471055/a-novel-in-situ-strategy-for-the-preparation-of-a-%C3%AE-cyclodextrin-polydopamine-coated-capillary-column-for-capillary-electrochromatography-enantioseparations
#9
Heying Guo, Xiaoying Niu, Congjie Pan, Tao Yi, Hongli Chen, Xingguo Chen
Inspired by the chiral recognition ability of β-cyclodextrin and the natural adhesive properties of polydopamine under alkaline conditions, in this study, a rapid and in situ modification strategy was developed to fabricate β-cyclodextrin/polydopamine composite material coated-capillary columns for open tubular capillary electrochromatography. The results of scanning electron microscopy, FTIR spectroscopy, streaming potential and electro-osmotic flow studies indicated that β-cyclodextrin/polydopamine was successfully fixed on the inner wall of the capillary column...
May 4, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28468863/hey-factors-at-the-crossroad-of-tumorigenesis-and-clinical-therapeutic-modulation-of-hey-for-anticancer-treatment
#10
REVIEW
Zihao Liu, Andrew J Sanders, Gehao Liang, Erwei Song, Wen G Jiang, Chang Gong
Hairy and Enhancer-of-split related with YRPW motif (Hey) transcription factors are important regulators of stem cell embryogenesis. Clinical relevance shows that they are also highly expressed in malignant carcinoma. Recent studies have highlighted functions for the Hey factors in tumor metastasis, the maintenance of cancer cell self-renewal, as well as proliferation and the promotion of tumor angiogenesis. Pathways that regulate Hey gene expression, such as Notch and TGFβ signaling, are frequently aberrant in numerous cancers...
May 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28468860/evaluation-of-the-sensitivity-and-specificity-performance-of-the-elecsys%C3%A2-htlv-i-ii-assay-in-a-multicenter-study-in-europe-and-japan
#11
Syria Laperche, Silvia Sauleda, Maria Piron, Annelies Mühlbacher, Harald Schennach, Volkmar Schottstedt, Lucinda Queirós, Naoki Uno, Katsunori Yanagihara, Roland Imdahl, Ariann Hey, Markus Klinkicht, Walter Melchior, Peter Muench, Toshiki Watanabe
Screening of blood for human T-cell lymphotropic virus type I and type II (HTLV-I/II) is important to diagnose and prevent infection and ensure the safety of blood supplies. The Elecsys® HTLV-I/II assay is a newly developed, electrochemiluminescence screening assay for the detection of HTLV-I/II infection. The sensitivity and specificity of the Elecsys® HTLV-I/II assay were determined using well-characterized HTLV-I/II-positive serum and plasma samples, and routine diagnostic and blood donor samples expected to be HTLV-negative, respectively...
May 3, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28465267/outcome-of-endoscopic-transsphenoidal-surgery-for-acromegaly
#12
Jung Hee Kim, Kyu Yeon Hur, Jung Hyun Lee, Ji Hyun Lee, Young-Bem Se, Hey In Kim, Seung Hoon Lee, Do-Hyun Nam, Seong Yeon Kim, Kwang-Won Kim, Doo-Sik Kong, Yong Hwy Kim
OBJECTIVE: Endoscopic transsphenoidal surgery has recently been introduced in pituitary surgery. We investigated outcomes and complications of endoscopic surgery in two referral centers in Korea. METHODS: We enrolled 134 patients with acromegaly (microadenomas, n=15; macroadenomas, n=119) who underwent endoscopic transsphenoidal surgery at Seoul National University Hospital (n=74) and Samsung Medical center (n=60) between Jan 2009 and Mar 2016. Remission was defined as having a normal IGF-1 and a suppressed GH less than 1 ng/mL during an oral glucose tolerance test...
April 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28456193/isotropic-nematic-phase-transition-of-uniaxial-variable-softness-prolate-and-oblate-ellipsoids
#13
G Rickayzen, D M Heyes
Onsager's theory of the isotropic-nematic phase separation of rod shaped particles is generalized to include particle softness and attractions in the anisotropic interparticle force field. The procedure separates a scaled radial component from the angular integral part, the latter being treated in essentially the same way as in the original Onsager formulation. Building on previous treatments of more idealised hard-core particle models, this is a step toward representing more realistic rod-like systems and also allowing temperature (and in principle specific chemical factors) to be included at a coarse grained level in the theory...
April 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28451315/engineering-proximal-vs-distal-heme-no-coordination-via-dinitrosyl-dynamics-implications-for-no-sensor-design
#14
Demet Kekilli, Christine A Petersen, David A Pixton, Dlzar D Ghafoor, Gaylany H Abdullah, Florian S N Dworkowski, Michael T Wilson, Derren J Heyes, Samantha J O Hardman, Loretta M Murphy, Richard W Strange, Nigel S Scrutton, Colin R Andrew, Michael A Hough
Proximal vs. distal heme-NO coordination is a novel strategy for selective gas response in heme-based NO-sensors. In the case of Alcaligenes xylosoxidans cytochrome c' (AXCP), formation of a transient distal 6cNO complex is followed by scission of the trans Fe-His bond and conversion to a proximal 5cNO product via a putative dinitrosyl species. Here we show that replacement of the AXCP distal Leu16 residue with smaller or similar sized residues (Ala, Val or Ile) traps the distal 6cNO complex, whereas Leu or Phe residues lead to a proximal 5cNO product with a transient or non-detectable distal 6cNO precursor...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28445549/impact-of-the-c-mybe308g-mutation-on-mouse-myelopoiesis-and-dendritic-cell-development
#15
Peter Papathanasiou, Sawang Petvises, Ying-Ying Hey, Andrew C Perkins, Helen C O'Neill
Booreana mice carrying the c-Myb308G point mutation were analyzed to determine changes in early hematopoiesis in the bone marrow and among mature cells in the periphery. This point mutation led to increased numbers of early hematopoietic stem and progenitor cells (HSPCs), with a subsequent reduction in the development of B cells, erythroid cells, and neutrophils, and increased numbers of myeloid cells and granulocytes. Myelopoiesis was further investigated by way of particular subsets affected. A specific question addressed whether booreana mice contained increased numbers of dendritic-like cells (L-DC subset) recently identified in the spleen, since L-DCs arise in vitro by direct differentiation from HSPCs co-cultured over splenic stroma...
2017: PloS One
https://www.readbyqxmd.com/read/28435985/elucidating-the-a%C3%AE-42-anti-aggregation-mechanism-of-action-of-tramiprosate-in-alzheimer-s-disease-integrating-molecular-analytical-methods-pharmacokinetic-and-clinical-data
#16
Petr Kocis, Martin Tolar, Jeremy Yu, William Sinko, Soumya Ray, Kaj Blennow, Howard Fillit, John A Hey
BACKGROUND: Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer's disease (AD) and represent a promising target for drug development. Tramiprosate is a small-molecule Aβ anti-aggregation agent that was evaluated in phase III clinical trials for AD but did not meet the primary efficacy endpoints; however, a pre-specified subgroup analysis revealed robust, sustained, and clinically meaningful cognitive and functional effects in patients with AD homozygous for the ε4 allele of apolipoprotein E4 (APOE4/4 homozygotes), who carry an increased risk for the disease...
April 24, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28435927/traumatic-dislocation-of-the-s1-polyaxial-pedicle-screw-head-a-case-report
#17
Pieter N B Du Plessis, Bernard P H Lau, Hwee Weng Dennis Hey
Polyaxial screw head dislocation in the absence of a manufacture defect is extremely rare and represents a biomechanical overload of the screw, leading to early failure. A 58-year-old gentleman underwent instrumented fusion using polyaxial pedicle screws-titanium rod construct with interbody cage for spondylolytic spondylolisthesis at the L5/S1 level. He attempted to bend forward ten days after the surgery which resulted in a dislocation of the right S1 polyaxial screw head from the screw shank with recurrence of symptoms...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435926/lumbar-disc-herniation-presenting-with-contralateral-symptoms-a-case-report
#18
Zhi Sheng Darren Koh, Shuxun Lin, Hwee Weng Dennis Hey
Lumbar disc herniation is common and may be symptomatic. The magnetic resonance imaging (MRI) scan is an appropriate tool to confirm the diagnosis and affected level of the spine. While a disc herniation is usually associated with ipsilateral symptoms, a few cases have been reported to present with contralateral symptoms. We report a unique case of left lumbar disc herniation at L5/S1 who presented with contralateral symptoms and was successfully treated with a right L5/S1 foraminal block. However, the patient developed concordant ipsilateral symptoms 6 weeks later and was treated with left L5/S1 microdiscectomy...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435925/distal-junctional-failure-secondary-to-l5-vertebral-fracture-a-report-of-two-rare-cases
#19
Jiong Hao Tan, Kimberly-Anne Tan, Hwee Weng Dennis Hey, Hee-Kit Wong
Distal junctional failure (DJF) with fracture at the last instrumented vertebra is a rare occurrence. In this case report, we present two patients with L5 vertebral fracture post-instrumented fusion of the lumbar spine. The first patient is a 78-year-old female who had multi-level degenerative disc disease, spinal stenosis and degenerative scoliosis involving levels T12 to L5. She underwent instrumented posterolateral fusion (PLF) from T12 to L5, and transforaminal lumbar interbody fusion (TLIF) at L2/3 and L4/5...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435923/bone-bridge-formation-across-the-neuroforamen-14-years-after-instrumented-fusion-for-isthmic-spondylolisthesis-a-case-report
#20
Joel Louis Lim, Kimberly-Anne Tan, Hwee Weng Dennis Hey
This case report describes the first case of a bone bridge formation across the left L5/S1 neuroforamen after instrumented posterolateral fusion for L5/S1 isthmic spondylolisthesis. Our patient was a 70-year-old lady who had grade 2, L5/S1 isthmic spondylolisthesis and bilateral S1 nerve root compression. She suffered from mechanical low back pain and neurogenic claudication, with radicular pain over both S1 dermatomes. She underwent in-situ, instrumented, posterolateral fusion and was asymptomatic for more than 13 years before developing progressive onset of left radicular pain over the L5 dermatome...
March 2017: Journal of Spine Surgery (Hong Kong)
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