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https://www.readbyqxmd.com/read/28337159/hey-teacher-don-t-leave-them-kids-alone-action-is-better-for-memory-than-reading
#1
Mathieu Hainselin, Laurence Picard, Patrick Manolli, Sophie Vankerkore-Candas, Béatrice Bourdin
There is no consensus on how the enactment effect (EE), although it is robust, enhances memory. Researchers are currently investigating the cognitive processes underlying this effect, mostly during adulthood; the link between EE and crucial function identified in adulthood such as episodic memory and binding process remains elusive. Therefore, this study aims to verify the existence of EE in 6-10 years old and assess cognitive functions potentially linked to this effect in order to shed light on the mechanisms underlying the EE during childhood...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28333230/bayesian-analysis-of-evolutionary-divergence-with-genomic-data-under-diverse-demographic-models
#2
Yujin Chung, Jody Hey
We present a new Bayesian method for estimating demographic and phylogenetic history using population genomic data. Several key innovations are introduced that allow the study of diverse models within an Isolation with Migration framework. The new method implements a 2-step analysis, with an initial Markov chain Monte Carlo (MCMC) phase that samples simple coalescent trees, followed by the calculation of the joint posterior density for the parameters of a demographic model. In step 1, the MCMC sampling phase, the method uses a reduced state space, consisting of coalescent trees without migration paths, and a simple importance sampling distribution without the demography of interest...
February 25, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28315670/sulfatase-activity-assay-using-an-activity-based-probe-by-generation-of-n-methyl-isoindole-under-reducing-conditions
#3
Hey Young Yoon, Jong-In Hong
Sulfatases catalyze the hydrolysis of sulfate esters that are present in a range of biomolecules. This is an important step in several biological processes such as cellular degradation, hormone regulation, and cell signaling. We have developed a new activity-based sulfatase probe (probe 1) that generates a fluorescent N-methylisoindole upon hydrolysis by sulfatase. Because of the autoxidation of N-methylisoindole, the sulfatase activity was also tested under reducing conditions, containing either glutathione (GSH) or tris(2-carboxyethyl)phosphine (TCEP), exhibiting little change in kinetic parameters compared to non-reducing conditions...
March 16, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28306640/cervical-alignment-variations-in-different-postures-and-predictors-of-normal-cervical-kyphosis-a-new-understanding
#4
Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Chengyuan Gordon Wong, Kimberly-Anne Tan, Gabriel Ka-Po Liu, Hee-Kit Wong
STUDY DESIGN: Prospective comparative study OBJECTIVE.: To predict physiological alignment of the cervical spine and study its morphology in different postures. SUMMARY OF BACKGROUND DATA: There is increasing evidence that normal cervical spinal alignment may vary from lordosis to neutral to kyphosis, or form S-shaped or reverse S-shaped curves. METHODS: Standing, erect sitting and natural sitting whole spine radiographs were obtained from 26 consecutive patients without cervical spine pathology...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28301705/reprioritizing-research-activity-for-the-post-antibiotic-era-ethical-legal-and-social-considerations
#5
Spencer Phillips Hey, Aaron S Kesselheim
Many hold that the so-called golden era of antibiotic discovery has passed, leaving only a limited clinical pipeline for new antibiotics. A logical conclusion of such arguments is that we need to reform the current system of antibiotic drug research-including clinical trials and regulatory requirements-to spur activity in discovery and development. The United States Congress in the past few years has debated a number of bills to address this crisis, including the 2012 Generating Antibiotic Incentives Now Act and the 2016 21st Century Cures Act...
March 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28300782/erratum-sandeep-p-et-al-a-novel-secure-iot-based-smart-home-automation-system-using-a-wireless-sensor-network-sensors-2017-17-69
#6
Sandeep Pirbhulal, Heye Zhang, Md Eshrat E Alahi, Hemant Ghayvat, Subhas Chandra Mukhopadhyay, Yuan-Ting Zhang, Wanqing Wu
n/a.
March 16, 2017: Sensors
https://www.readbyqxmd.com/read/28300781/erratum-sandeep-p-et-al-an-efficient-biometric-based-algorithm-using-heart-rate-variability-for-securing-body-sensor-networks-sensors-2015-15-15067-15089
#7
Sandeep Pirbhulal, Heye Zhang, Subhas Chandra Mukhopadhyay, Chunyue Li, Yumei Wang, Guanglin Li, Wanqing Wu, Yuan-Ting Zhang
n/a.
March 16, 2017: Sensors
https://www.readbyqxmd.com/read/28296032/right-ventricular-remodelling-after-transcatheter-pulmonary-valve-implantation
#8
Efstathios D Pagourelias, Ana M Daraban, Razvan O Mada, Jürgen Duchenne, Oana Mirea, Bjorn Cools, Ruth Heying, Derize Boshoff, Jan Bogaert, Werner Budts, Marc Gewillig, Jens-Uwe Voigt
OBJECTIVES: To define the optimal timing for percutaneous pulmonary valve implantation (PPVI) in patients with severe pulmonary regurgitation (PR) after Fallot's Tetralogy (ToF) correction. BACKGROUND: PPVI among the aforementioned patients is mainly driven by symptoms or by severe right ventricular (RV) dilatation/dysfunction. The optimal timing for PPVI is still disputed. METHODS: Twenty patients [age 13.9 ± 9.2 years, (range 4.3-44...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28287825/quantification-of-residual-germinal-center-activity-and-hiv-1-dna-and-rna-levels-using-fine-needle-biopsies-of-lymph-nodes-during-antiretroviral-therapy
#9
William J Hey-Nguyen, Yin Xu, Chester F Pearson, Michelle Bailey, Kazuo Suzuki, Robyn Tantau, Solange Obeid, Brad Milner, Andrew Field, Andrew Carr, Mark Bloch, David A Cooper, Anthony D Kelleher, John J Zaunders, Kersten K Koelsch
HIV-1 reservoirs are most often studied in peripheral blood (PB), but not all lymphocytes recirculate, particularly T follicular helper (Tfh) CD4(+) T cells, as well as germinal center (GC) B cells, in lymph nodes (LNs). Ultrasound-guided fine needle biopsies (FNBs) from inguinal LNs and PB samples were obtained from 10 healthy controls (HCs) and 21 HIV-1-infected subjects [11 antiretroviral therapy (ART) naive and 10 on ART]. Tfh cells and GC B cells were enumerated by flow cytometry. HIV-1 DNA and cell-associated (CA) RNA levels in LNs and PB were quantified by real-time polymerase chain reaction...
March 13, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28280357/a-new-tumor-suppressor-lncrna-rp11-190d6-2-inhibits-the-proliferation-migration-and-invasion-of-epithelial-ovarian-cancer-cells
#10
Wenxian Tong, Liu Yang, Qiang Yu, Jie Yao, Anbing He
At present, a large number of long noncoding RNAs (lncRNAs) from the human genome have been discovered. Meanwhile, emerging evidence has indicated that lncRNAs could play a critical role in the regulation of cellular processes such as cancer progression and metastasis. However, the functions of some new lncRNAs in the complex transcriptional process are mostly unknown at present. Existing studies suggest that loss of WW domain-containing oxidoreductase (WWOX) expression is linked with poor prognosis in numerous cancers, including epithelial ovarian cancer (EOC)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28278103/evaluation-of-direct-membrane-filtration-and-direct-forward-osmosis-as-concepts-for-compact-and-energy-positive-municipal-wastewater-treatment
#11
Tobias Hey, Niada Bajraktari, Åsa Davidsson, Jörg Vogel, Henrik Tækker Madsen, Claus Hélix-Nielsen, Jes la Cour Jansen, Karin Jönsson
Municipal wastewater treatment commonly involves mechanical, biological and chemical treatment steps to protect humans and the environment from adverse effects. Membrane technology has gained increasing attention as an alternative to conventional wastewater treatment due to increased urbanization. Among the available membrane technologies, microfiltration and forward osmosis have been selected for this study due to their specific characteristics, such as compactness and efficient removal of particles. In this study, two treatment concepts were evaluated with regard to their specific electricity, energy and area demands...
February 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28270211/syndecan-1-is-a-novel-molecular-marker-for-triple-negative-inflammatory-breast-cancer-and-modulates-the-cancer-stem-cell-phenotype-via-the-il-6-stat3-notch-and-egfr-signaling-pathways
#12
Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte
BACKGROUND: Inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted therapies, the identification of molecular markers of IBC is of major importance. The heparan sulfate proteoglycan Syndecan-1 acts as a coreceptor for growth factors and chemokines, modulating inflammation, tumor progression, and cancer stemness, thus it may emerge as a molecular marker for IBC. METHODS: We characterized expression of Syndecan-1 and the CSC marker CD44, Notch-1 & -3 and EGFR in carcinoma tissues of triple negative IBC (n = 13) and non-IBC (n = 17) patients using qPCR and immunohistochemistry...
March 7, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28266231/multicentre-european-study-of-double-balloon-enteroscopy-for-small-bowel-pathology-in-patients-with-cardiovascular-disease
#13
Suneil A Raju, Hey-Long Ching, Frederica Branchi, Diana E Yung, Anastasios Koulaouzidis, John N Plevris, Luca Elli, David S Sanders, Reena Sidhu
No abstract text is available yet for this article.
March 7, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28261887/carboranes-as-aryl-mimetics-in-catalysis-a-highly-active-zwitterionic-nhc-precatalyst
#14
Christoph Selg, Wilma Neumann, Peter Lönnecke, Evamarie Hey-Hawkins, Kirsten Zeitler
Modern catalysis takes advantage of aryl-based interactions to tune and control reactions. In the design of N heterocyclic carbene catalysts both electronic and steric nature of the nitrogen substituents play a crucial role. While hydrocarbon-based systems and especially aryl residues have considerably contributed to surmount multifaceted catalytic challenges, the unique properties of carborane moieties such as delocalized charge, potential planar chirality and their well-known thermodynamic stability offer unprecedented opportunities to develop new catalysts while employing these as aryl mimetics...
March 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28254693/tlr4-md2-specific-peptides-stalled-in%C3%A2-vivo-lps-induced-immune-exacerbation
#15
Seolhee Park, Hyeon-Jun Shin, Masaud Shah, Hey-Young Cho, Muhammad Ayaz Anwar, Asma Achek, Hyuk-Kwon Kwon, Byugsung Lee, Tae Hyeon Yoo, Sangdun Choi
Negative regulation of Toll-like receptor-4 (TLR4) is anticipated to control the pathogen-induced exaggerated immune response. However, effective TLR4 antagonists with scarce off-target effects are yet to be developed. To fill this void, we sought to design small peptide-inhibitors of the TLR4/MD2-LPS interaction. Here we report novel TLR4-antagonistic peptides (TAP), identified through phage display, endowed with the LPS-induced proinflammation inhibition, and confirmed in mice. TAPs-attributed TLR4-antagonism were initially evaluated through NF-κB inhibition in HEK-blue hTLR4 and RAW264...
February 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28252247/a-sixteen-membered-au8-p8-macrocycle-based-on-gold-i-and-diphospha-iii-guanidine
#16
Anup K Adhikari, Menyhárt B Sárosi, Toni Grell, Peter Lönnecke, Evamarie Hey-Hawkins
The reaction of cyclo-P4 Mes4 C(NCy) (1) with two equivalents of [AuCl(tht)] (tht=tetrahydrothiophene) resulted in the formation of unusual sixteen-membered Au-P macrocycle 2. This macrocycle contains diphospha(III)guanidinate as a coordinating ligand, which is formed by P-P bond cleavage of 1. Macrocycle 2 was characterized by multinuclear NMR spectroscopy, mass spectrometry and X-ray crystallography.
March 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28244763/direct-evidence-of-an-excited-state-triplet-species-upon-photoactivation-of-the-chlorophyll-precursor-protochlorophyllide
#17
Guillem Brandariz-de-Pedro, Derren J Heyes, Samantha J O Hardman, Muralidharan Shanmugam, Alex R Jones, Stefan Weber, Daniel Nohr, Nigel S Scrutton, Alistair J Fielding
The chlorophyll precursor protochlorophyllide (Pchlide), which is the substrate for the light-driven enzyme protochlorophyllide oxidoreductase, has unique excited-state properties that facilitate photocatalysis. Previous time-resolved spectroscopy measurements have implied that a long-lived triplet state is formed during the excited-state relaxation of Pchlide, although direct evidence of its existence is still lacking. Here we use time-resolved electron paramagnetic resonance (EPR) in combination with time-resolved absorption measurements at a range of temperatures (10-290 K), solvents, and oxygen concentrations to provide a detailed characterization of the triplet state of Pchlide...
March 2, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28240957/evaluation-of-gene-expression-and-dna-copy-number-profiles-of-adipose-tissue-derived-stromal-cells-and-consecutive-neurosphere-like-cells-generated-from-dogs-with-naturally-occurring-spinal-cord-injury
#18
Ji-Hey Lim, Sehwon Koh, Rachael Thomas, Matthew Breen, Natasha J Olby
OBJECTIVE To evaluate gene expression and DNA copy number in adipose tissue-derived stromal cells (ADSCs) and in ADSC-derived neurosphere-like cell clusters (ADSC-NSCs) generated from tissues of chronically paraplegic dogs. ANIMALS 14 client-owned paraplegic dogs. PROCEDURES Dorsal subcutaneous adipose tissue (< 1 cm(3)) was collected under general anesthesia; ADSCs were isolated and cultured. Third-passage ADSCs were cultured in neural cell induction medium to generate ADSC-NSCs. Relative gene expression of mesenchymal cell surface marker CD90 and neural progenitor marker nestin was assessed in ADSCs and ADSC-NSCs from 3 dogs by quantitative real-time PCR assay; expression of these and various neural lineage genes was evaluated for the same dogs by reverse transcription PCR assay...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28240654/lumbar-spine-alignment-in-6-common-postures-a-rom-analysis-with-implications-for-deformity-correction
#19
Hwee Weng Dennis Hey, Eugene Tze-Chun Lau, Kimberly-Anne Tan, Joel Louis Lim, Denise Choong, Leok-Lim Lau, Ka-Po Gabriel Liu, Hee-Kit Wong
STUDY DESIGN: . A prospective cross-sectional study. OBJECTIVE: To compare lumbar spine alignment in 6 common postures, and estimate loss in range of motion (ROM) relative to standing. SUMMARY OF BACKGROUND DATA: Ideal position for fusion of lumbar spine remains unknown. While surgical fusion is necessary for deformity correction and symptom relief, the final position in which the vertebrae are immobilized should provide maximum residual function...
February 24, 2017: Spine
https://www.readbyqxmd.com/read/28239214/mental-imagery-based-training-to-modify-mood-and-cognitive-bias-in-adolescents-effects-of-valence-and-perspective
#20
S Burnett Heyes, A Pictet, H Mitchell, S M Raeder, J Y F Lau, E A Holmes, S E Blackwell
Mental imagery has a powerful impact on emotion and cognitive processing in adults, and is implicated in emotional disorders. Research suggests the perspective adopted in mental imagery modulates its emotional impact. However, little is known about the impact of mental imagery in adolescence, despite adolescence being the key time for the onset of emotional dysfunction. We administered computerised positive versus mixed valence picture-word mental imagery training to male adolescent participants (N = 60, aged 11-16 years) across separate field and observer perspective sessions...
2017: Cognitive Therapy and Research
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