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https://www.readbyqxmd.com/read/28093552/integrating-hebbian-and-homeostatic-plasticity-the-current-state-of-the-field-and-future-research-directions
#1
REVIEW
Tara Keck, Taro Toyoizumi, Lu Chen, Brent Doiron, Daniel E Feldman, Kevin Fox, Wulfram Gerstner, Philip G Haydon, Mark Hübener, Hey-Kyoung Lee, John E Lisman, Tobias Rose, Frank Sengpiel, David Stellwagen, Michael P Stryker, Gina G Turrigiano, Mark C van Rossum
We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28093550/experience-dependent-homeostasis-of-noise-at-inhibitory-synapses-preserves-information-coding-in-adult-visual-cortex
#2
Ming Gao, Jessica L Whitt, Shiyong Huang, Angela Lee, Stefan Mihalas, Alfredo Kirkwood, Hey-Kyoung Lee
Synapses are intrinsically 'noisy' in that neurotransmitter is occasionally released in the absence of an action potential. At inhibitory synapses, the frequency of action potential-independent release is orders of magnitude higher than that at excitatory synapses raising speculations that it may serve a function. Here we report that the frequency of action potential-independent inhibitory synaptic 'noise' (i.e. miniature inhibitory postsynaptic currents, mIPSCs) is highly regulated by sensory experience in visual cortex...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28091874/the-influence-of-dental-treatment-on-the-development-of-osteoradionecrosis-after-radiotherapy-by-modern-irradiation-techniques
#3
Ramona Schweyen, Andreas Stang, Andreas Wienke, Alexander Eckert, Thomas Kuhnt, Jeremias Hey
OBJECTIVES: The aim of this study was to analyze the influence of dental treatment on the development of osteoradionecrosis (ORN) of the jaw. METHODS: This study included the data of 776 patients who underwent 3D-CRT or IMRT because of head and neck cancer. Sex, dental status before and after radiotherapy (RT), tumor site, bone surgery during tumor operation, concomitant chemotherapy, and the development of an advanced ORN were documented for each patient. The patients' dentitions before and after RT were classified into four groups with regard to the number and localization of the remaining teeth...
January 13, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28089276/simultaneous-separation-of-neutral-and-cationic-analytes-by-one-dimensional-open-tubular-capillary-electrochromatography-using-zeolitic-imidazolate-framework-8-as-stationary-phase
#4
Congjie Pan, Wenjuan Lv, Guoxiu Wang, Xiaoying Niu, Heying Guo, Xingguo Chen
Developing simple methods for separation of analytes that belong to different classes is of great importance. Herein, we developed a simple one-dimensional (1-D) capillary electrochromatography method to demonstrate the simultaneous separation of target fractions that belong to two different classes (i.e., cationic and neutral analytes) without switching buffer solution by a zeolitic imidazolate framework ZIF-8 coated capillary column. Owing to the difference of charge-to-mass ratio of the cationic analytes, the interaction of the cationic analytes and coating material ZIF-8 and the hydrophobic interactions between the neutral analytes and the microporous framework of ZIF-8, six cationic analytes and four neutral analytes were simultaneously separated in a single run by 1-D capillary electrochromatography...
January 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28077081/antigen-presenting-capacity-of-murine-splenic-myeloid-cells
#5
Ying-Ying Hey, Benjamin Quah, Helen C O'Neill
BACKGROUND: The spleen is an important site for hematopoiesis. It supports development of myeloid cells from bone marrow-derived precursors entering from blood. Myeloid subsets in spleen are not well characterised although dendritic cell (DC) subsets are clearly defined in terms of phenotype, development and functional role. Recently a novel dendritic-like cell type in spleen named 'L-DC' was distinguished from other known dendritic and myeloid cells by its distinct phenotype and developmental origin...
January 11, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28065817/reproducibility-of-sagittal-radiographic-parameters-in-adolescent-idiopathic-scoliosis-a-guide-to-reference-values-using-serial-imaging
#6
Hwee Weng Dennis Hey, Gordon Chengyuan Wong, Chloe Chan Xiaoyun, Leok-Lim Lau, Naresh Kumar, Joseph Shantakumar Thambiah, John Nathaniel Ruiz, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: Knowledge of sagittal radiographical parameters in AIS patients has not yet caught up with our understanding of their roles in patients with adult spinal deformity. It is likely that more emphasis will be placed in restoring sagittal parameters for AIS patients in the future. Therefore we need to understand how these parameters may vary in AIS to facilitate management plans. PURPOSE: To determine the reproducibility of sagittal spinal parameters on lateral film radiographs in patients with AIS...
January 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28062170/an-artificial-neural-network-method-for-lumen-and-media-adventitia-border-detection-in-ivus
#7
Shengran Su, Zhenghui Hu, Qiang Lin, William Kongto Hau, Zhifan Gao, Heye Zhang
Intravascular ultrasound (IVUS) has been well recognized as one powerful imaging technique to evaluate the stenosis inside the coronary arteries. The detection of lumen border and media-adventitia (MA) border in IVUS images is the key procedure to determine the plaque burden inside the coronary arteries, but this detection could be burdensome to the doctor because of large volume of the IVUS images. In this paper, we use the artificial neural network (ANN) method as the feature learning algorithm for the detection of the lumen and MA borders in IVUS images...
November 17, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28053367/improving-health-care-quality-in-resource-poor-settings
#8
Bejoy Nambiar, Dougal S Hargreaves, Chelsea Morroni, Michelle Heys, Sonya Crowe, Christina Pagel, Felicity Fitzgerald, Susana Frazao Pinheiro, Delan Devakumar, Sue Mann, Monica Lakhanpaul, Martin Marshall, Tim Colbourn
No abstract text is available yet for this article.
January 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28045924/effects-of-spatial-localization-on-microbial-consortia-growth
#9
Michael Venters, Ross P Carlson, Tomas Gedeon, Jeffrey J Heys
Microbial consortia are commonly observed in natural and synthetic systems, and these consortia frequently result in higher biomass production relative to monocultures. The focus here is on the impact of initial spatial localization and substrate diffusivity on the growth of a model microbial consortium consisting of a producer strain that consumes glucose and produces acetate and a scavenger strain that consumes the acetate. The mathematical model is based on an individual cell model where growth is described by Monod kinetics, and substrate transport is described by a continuum-based, non-equilibrium reaction-diffusion model where convective transport is negligible (e...
2017: PloS One
https://www.readbyqxmd.com/read/28042831/a-novel-secure-iot-based-smart-home-automation-system-using-a-wireless-sensor-network
#10
Sandeep Pirbhulal, Heye Zhang, Md Eshrat E Alahi, Hemant Ghayvat, Subhas Chandra Mukhopadhyay, Yuan-Ting Zhang, Wanqing Wu
Wireless sensor networks (WSNs) provide noteworthy benefits over traditional approaches for several applications, including smart homes, healthcare, environmental monitoring, and homeland security. WSNs are integrated with the Internet Protocol (IP) to develop the Internet of Things (IoT) for connecting everyday life objects to the internet. Hence, major challenges of WSNs include: (i) how to efficiently utilize small size and low-power nodes to implement security during data transmission among several sensor nodes; (ii) how to resolve security issues associated with the harsh and complex environmental conditions during data transmission over a long coverage range...
December 30, 2016: Sensors
https://www.readbyqxmd.com/read/28038466/drug-dependent-functionalization-of-wild-type-and-mutant-p53-in-cisplatin-resistant-human-ovarian-tumor-cells
#11
Michelle Bhatt, Cristina Ivan, Xiaolei Xie, Zahid H Siddik
Cisplatin (cis-Pt) resistance in tumor cells from p53 dysfunction is a significant clinical problem. Although mutation can inhibit p53 function, >60% of p53 mutants retain normal function according to literature reports. Therefore, we examined the status of p53 in cisplatin-resistant ovarian tumor models and its functional response to cis-Pt and the mechanistically-distinct non-cross-resistant oxaliplatin (oxali-Pt). Relative to sensitive A2780 cells harboring wild-type p53, the 2780CP/Cl-16, OVCAR-10, Hey and OVCA-433 cell lines were 10- to 30-fold resistant to cis-Pt, but was substantially circumvented by oxali-Pt...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28031412/dual-pi3k-mtor-inhibition-in-colorectal-cancers-with-apc-and-pik3ca-mutations
#12
Tyler M Foley, Susan N Payne, Cheri A Pasch, Alex E Yueh, Dana R Van De Hey, Demetra P Korkos, Linda Clipson, Molly E Maher, Kristina A Matkowskyj, Michael A Newton, Dustin A Deming
: Therapeutic targeting of the phosphoinositide 3-kinase (PI3K) pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer (CRC), though the population of patients who would benefit from targeting this pathway has yet to be identified...
December 28, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28025280/what-accounts-for-the-relationship-between-internet-use-and-suicidal-ideation-of-korean-older-adults-a-mediation-analysis
#13
Hey Jung Jun, Myoung-Yong Kim
OBJECTIVES: This study sought to examine the relationship between Internet use and suicidal ideation in Korean older adults and the mediating roles of social relationships and depressive symptoms. METHOD: A nationally representative sample of older adults aged 50 or older (N = 6,306), from four waves of the Korean Welfare Panel Study, was used in the analyses. All analyses were conducted using generalized estimation equations, and the mediation effects of social relationship satisfaction and depression in the relationship between Internet use and suicidal ideation were calculated using the product-of-coefficients approach...
December 26, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28025276/imgui-a-desktop-gui-application-for-isolation-with-migration-analyses
#14
Jared Knoblauch, Arun Sethuraman, Jody Hey
The Isolation with Migration (IM) programs (e.g., IMa2) have been utilized extensively by evolutionary biologists for model-based inference of demographic parameters including effective population sizes, migration rates, and divergence times. Here, we describe a graphical user interface for the latest IM program. IMGui provides a comprehensive set of tools for performing demographic analyses, tracking progress of runs, and visualizing results. Developed using node. js and the Electron framework, IMGui is an application that runs on any desktop operating system, and is available for download at https://github...
December 25, 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28019674/hairy-and-enhancer-of-split-related-with-yrpw-motif-like-heyl-is-dispensable-for-bone-remodeling-in-mice
#15
Ernesto Canalis, Stefano Zanotti
Notch induces Hairy Enhancer of Split (Hes)1 and Hes-related with YRPW motif (Hey) Hey1, Hey2 and Hey-like (HeyL) expression in osteoblasts, but it is not known whether any of these target genes mediates the effect of Notch in the skeleton. We demonstrated that Notch1 activation in osteoblasts/osteocytes induces Hes1, Hey1, Hey2 and HeyL, but HeyL was induced to a greater extent than other target genes. To characterize HeyL null mice for their skeletal phenotype, microcomputed tomography (µCT) and histomorphometric analysis of HeyL null and sex-matched littermate controls was performed...
December 26, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28004770/multimodal-magnetic-resonance-and-near-infrared-fluorescent-imaging-of-intraperitoneal-ovarian-cancer-using-a-dual-mode-dual-gadolinium-liposomal-contrast-agent
#16
M K Ravoori, S Singh, R Bhavane, A K Sood, B Anvari, J Bankson, A Annapragada, V Kundra
The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cancer. We assessed whether a dual-mode, dual-Gadolinium (DM-Dual-Gd-ICG) contrast agent can be used to visualize ovarian tumors in the peritoneal cavity by multimodal MR and near infra-red imaging (NIR)...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28004069/-emodin-ameliorates-the-peritoneal-dialysis-related-peritoneal-fibrosis-via-inhibiting-the-activation-of-notch-pathway
#17
Hui-Chao Wang, Xu-Hong Lin, Xiao-Peng Fang, Xiao-Yun Mu, Tie-Jun Li, Jian-Lin Liu
Long term peritoneal dialysis (PD) is often associated with peritoneal fibrosis. The aim of this study was to explore the effect of emodin on PD-related peritoneal fibrosis and its related cellular and molecular mechanism. PD-related peritoneal fibrosis rats and cultured rat peritoneal mesothelial cells were recruited in the experiment. PD-related peritoneal fibrosis was induced by intraperitoneal injection of lactate-buffered solution containing 4.25% glucose. The peritoneal equilibrium test (PET) was performed at the end of 2 weeks, 4 weeks, and 6 weeks, respectively...
December 25, 2016: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28001283/hey-mister-tambourine-man-play-a-drug-for-me-music-as-medication
#18
Robert H Howland
Listening to music may be thought of as noninvasive and nonpharmacological, but music should be considered a drug therapy. Music exposure has measurable neurobiological effects that are linked to systems regulating reward, motivation, and pleasure; stress and arousal; and immunity. Functional neuroimaging and lesion studies demonstrate that music-evoked emotions are associated with modulation of linked limbic and paralimbic brain regions. Some of these regions are involved in reward, motivation, and pleasure, and there are additional projections to brain structures regulating autonomic, emotional, and cognitive function...
December 1, 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28001157/multidentate-2-pyridyl-phosphine-ligands-towards-ligand-tuning-and-chirality
#19
S Hanf, R García-Rodríguez, S Feldmann, A D Bond, E Hey-Hawkins, D S Wright
In the current work a range of multidentate pyridyl-phosphine ligands are synthesised with tuneable electronic and steric character, through the incorporation of a variety of alcohols into (amino)pyridyl-phosphine frameworks. The stoichiometric reactions of compounds of the type (R2N)xP(2-py)3-x (2-py = 2-pyridyl) with alkyl as well as aryl alcohols result in the formation of (alkoxy)pyridyl-phosphines (RO)xP(2-py)3-x (R = Me, 2-Bu, Ph). This synthetic procedure also allows the introduction of enantiomerically pure alcohols, like (R)-(-)-2-BuOH and (S)-(+)-2-BuOH, and as such provides a very convenient two-step route to chiral multidentate pyridyl-phosphine ligand sets...
December 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27997575/the-heat-shock-transcription-factor-hsf1-induces-ovarian-cancer-epithelial-mesenchymal-transition-in-a-3d-spheroid-growth-model
#20
Chase D Powell, Trillitye R Paullin, Candice Aoisa, Christopher J Menzie, Ashley Ubaldini, Sandy D Westerheide
Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of cancers and is vital to cellular proliferation and invasion in some cancers. Upon analysis of various patient data sets, we find that HSF1 is frequently overexpressed in ovarian tumor samples. In order to determine the role of HSF1 in ovarian cancer, inducible HSF1 knockdown cell lines were created...
2016: PloS One
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