keyword
https://read.qxmd.com/read/38642627/a-framework-for-longitudinal-latent-factor-modelling-of-treatment-response-in-clinical-trials-with-applications-to-psoriatic-arthritis-and-rheumatoid-arthritis
#21
JOURNAL ARTICLE
Fabian Falck, Xuan Zhu, Sahra Ghalebikesabi, Matthias Kormaksson, Marc Vandemeulebroecke, Cong Zhang, Ruvie Martin, Stephen Gardiner, Chun Hei Kwok, Dominique M West, Luis Santos, Chengeng Tian, Yu Pang, Aimee Readie, Gregory Ligozio, Kunal K Gandhi, Tom Nichols, Ann-Marie Mallon, Luke Kelly, David Ohlssen, George Nicholson
OBJECTIVE: Clinical trials involve the collection of a wealth of data, comprising multiple diverse measurements performed at baseline and follow-up visits over the course of a trial. The most common primary analysis is restricted to a single, potentially composite endpoint at one time point. While such an analytical focus promotes simple and replicable conclusions, it does not necessarily fully capture the multi-faceted effects of a drug in a complex disease setting. Therefore, to complement existing approaches, we set out here to design a longitudinal multivariate analytical framework that accepts as input an entire clinical trial database, comprising all measurements, patients, and time points across multiple trials...
April 18, 2024: Journal of Biomedical Informatics
https://read.qxmd.com/read/38635483/asymmetrical-atrophy-of-the-paraspinal-muscles-in-patients-undergoing-unilateral-lumbar-medial-branch-radiofrequency-neurotomy
#22
JOURNAL ARTICLE
Ali E Guven, Gisberto Evangelisti, Marco D Burkhard, Paul Köhli, Jan Hambrecht, Jiaqi Zhu, Erika Chiapparelli, Michael Kelly, Koki Tsuchiya, Krizia Amoroso, Arman Zadeh, Jennifer Shue, Ek Tsoon Tan, Andrew A Sama, Federico P Girardi, Frank P Cammisa, Alexander P Hughes
Lumbar medial branch radiofrequency neurotomy (RFN), a common treatment for chronic low back pain due to facet joint osteoarthritis (FJOA), may amplify paraspinal muscle atrophy due to denervation. This study aimed to investigate the asymmetry of paraspinal muscle morphology change in patients undergoing unilateral lumbar medial branch RFN. Data from patients who underwent RFN between March 2016 and October 2021 were retrospectively analyzed. Lumbar foramina stenosis (LFS), FJOA, and fatty infiltration (FI) functional cross-sectional area (fCSA) of the paraspinal muscles were assessed on preinterventional and minimum 2-year postinterventional MRI...
March 22, 2024: Pain
https://read.qxmd.com/read/38633668/segment-selection-for-fusion-and-artificial-disc-replacement-in-the-hybrid-surgical-treatment-of-noncontiguous-cervical-spondylosis-a-finite-element-analysis
#23
JOURNAL ARTICLE
Xiangyao Sun, Jiang Huang, Qingming Zhang, Li Cao, Yuqi Liu, Zelong Song, Wei Tang, Siyuan Sun, Juyong Wang
Introduction: The treatment of skip-level cervical degenerative disease (CDD) with no degenerative changes observed in the intervening segment (IS) is complicated. This research aims to provide a reference basis for selecting treatment approaches for noncontiguous CDD. Methods: To establish accurate finite element models (FEMs), this study included computed tomography (CT) data from 21 patients with CDD (10 males and 11 females) for modeling. The study primarily discusses four cross-segment surgical approaches: upper (C3/4) anterior cervical discectomy and fusion (ACDF) and lower (C5/6) cervical disc arthroplasty (CDA), FA model; upper CDA (C3/4) and lower ACDF (C5/6), AF model; upper ACDF (C3/4) and lower ACDF (C5/6), FF model; upper CDA (C3/4) and lower CDA (C5/6), AA model...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38611668/deep-learning-detection-and-segmentation-of-facet-joints-in-ultrasound-images-based-on-convolutional-neural-networks-and-enhanced-data-annotation
#24
JOURNAL ARTICLE
Lingeer Wu, Di Xia, Jin Wang, Si Chen, Xulei Cui, Le Shen, Yuguang Huang
The facet joint injection is the most common procedure used to release lower back pain. In this paper, we proposed a deep learning method for detecting and segmenting facet joints in ultrasound images based on convolutional neural networks (CNNs) and enhanced data annotation. In the enhanced data annotation, a facet joint was considered as the first target and the ventral complex as the second target to improve the capability of CNNs in recognizing the facet joint. A total of 300 cases of patients undergoing pain treatment were included...
April 2, 2024: Diagnostics
https://read.qxmd.com/read/38606327/best-practice-guidelines-for%C3%A2-clinical-and%C3%A2-radiological-assessment-of%C3%A2-patients-with-femoroacetabular-impingement-results-from-the-isha-international-delphi-consensus-project-phase-2
#25
JOURNAL ARTICLE
Sarkhell Radha, Jonathan Hutt, Ajay Lall, Benjamin Domb, T Sean Lynch, Damian Griffin, Richard E Field, Josip Chuck-Cakic
In 2018, the International Society for Hip Preservation Surgery (ISHA) initiated a series of Delphi consensus studies to identify the global hip preservation community's current opinion on best practices for different facets of hip preservation surgery. Arthroscopic procedures to treat hip pathologies, such as femoroacetabular impingement syndrome (FAIS) are now established in mainstream orthopaedic practice. This study establishes recommendations for the investigation of patients with suspected FAIS. The investigation has focused on the three phases of the diagnostic process-patient history, physical examination and special investigations...
January 2024: Journal of Hip Preservation Surgery
https://read.qxmd.com/read/38601321/anatomy-of-the-naviculocuneiform-joint-complex
#26
JOURNAL ARTICLE
George Borrelli, Maxwell Albiero, James Jastifer
BACKGROUND: The purpose of this study was to quantify the articular surfaces of the naviculocuneiform (NC) joint to help clinicians better understand common pathologies observed such as navicular stress fractures and arthrodesis nonunions. METHODS: Twenty cadaver NC joints were dissected and the articular cartilage of the navicular, medial, middle, and lateral cuneiforms were quantified by calibrated digital imaging software. Statistical analysis included calculating the mean cartilage surface area dimensions of the distal navicular and proximal cuneiform bones...
April 2024: Foot & ankle orthopaedics
https://read.qxmd.com/read/38600941/analyzing-isolated-degeneration-of-lumbar-facet-joints-implications-for-degenerative-instability-and-lumbar-biomechanics-using-finite-element-analysis
#27
JOURNAL ARTICLE
Jun Sung Park, Tae Sik Goh, Jung Sub Lee, Chiseung Lee
The facet joint contributes to lumbar spine stability as it supports the weight of body along with the intervertebral discs. However, most studies on the causes of degenerative lumbar diseases focus on the intervertebral discs and often overlook the facet joints. This study aimed to investigate the impact of facet joint degeneration on the degenerative changes and diseases of the lumbar spine. A finite element model of the lumbar spine (L1-S1) was fabricated and validated to study the biomechanical characteristics of the facet joints...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38597223/radiofrequency-for-chronic-lumbosacral-and-cervical-pain-results-of-a-consensus-study-using-the-rand-ucla-appropriateness-method
#28
JOURNAL ARTICLE
Javier de Andrés Ares, Sam Eldabe, Nicky Helsen, Ganesan Baranidharan, Jean-Luc Barat, Arun Bhaskar, Fabrizio Cassini, Sebastian Gillner, Jan Willem Kallewaard, Stephan Klessinger, Philippe Mavrocordatos, Felice Occhigrossi, Jan Van Zundert, Frank Huygen, Herman Stoevelaar
BACKGROUND: Despite the routine use of radiofrequency (RF) for the treatment of chronic pain in the lumbosacral and cervical region, there remains uncertainty on the most appropriate patient selection criteria. This study aimed to develop appropriateness criteria for RF in relation to relevant patient characteristics, considering RF ablation (RFA) for the treatment of chronic axial pain and pulsed RF (PRF) for the treatment of chronic radicular pain. METHODS: The RAND/UCLA Appropriateness Method (RUAM) was used to explore the opinions of a multidisciplinary European panel on the appropriateness of RFA and PRF for a variety of clinical scenarios...
April 10, 2024: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/38597179/comparison-of-open-surgery-versus-minimally-invasive-surgery-in-non-severe-adult-degenerative-scoliosis-a-systematic-review-and-meta-analysis
#29
JOURNAL ARTICLE
Zhenxuan Shao, Haibo Liang, Sunlong Li, Zhaoming Ye, Xiangyang Wang
STUDY DESIGN: A systematic review and meta-analysis. OBJECTIVE: This study aimed to evaluate the clinical efficacy of minimally invasive surgery (MIS) and open surgery in correcting ADS. SUMMARY OF BACKGROUND DATA: Adult degenerative scoliosis (ADS) is a scoliosis secondary to degenerative changes in the intervertebral discs and facet joints in adults. Severe low back pain, radicular pain, and intermittent claudication are often present and require surgical treatment...
April 10, 2024: Spine
https://read.qxmd.com/read/38592668/odontoid-fracture-with-accompanying-severe-atlantoaxial-instability-in-elderly-patients-analysis-of-treatment-adverse-events-and-outcome
#30
JOURNAL ARTICLE
Michael Kreinest, Philipp Raisch, Lukas Hörnig, Sven Y Vetter, Paul A Grützner, Matthias K Jung
(1) Background: In elderly patients with type II odontoid fractures, accompanying severe atlantoaxial instability (AAI) is discussed as a marker possibly warranting more aggressive surgical therapy. This study aimed to characterize adverse events as well as the radiological and functional outcomes of surgical vs. conservative therapy in patients with odontoid fracture and AAI. (2) Methods: Patients aged 65 years and older with type II odontoid fracture and AAI treated were included. AAI was assumed if the mean subluxation across both atlantoaxial facet joints in the sagittal plane was greater than 50%...
February 26, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38585281/costotransverse-joint-ankylosis-and-their-association-with-syndesmophyte-progression-in-patients-with-radiographic-axial-spondyloarthritis
#31
JOURNAL ARTICLE
Hong Ki Min, Se Hee Kim, Sang-Heon Lee, Hae-Rim Kim, Sang-Hoon Lee
BACKGROUND: Abnormal new bone formation can occur not only in the vertebral body but also can occur in facet, costovertebral, and costotransverse joints in radiographic axial spondyloarthritis (r-axSpA) patients. Little is known about the association between syndesmophyte progression and paravertebral joint ankylosis in r-axSpA. OBJECTIVES: Costotransverse joint ankylosis in r-axSpA patients was measured. Furthermore, the association between syndesmophyte progression for 2 years assessed by computed tomography syndesmophyte score (CTSS) and facet, costovertebral, and costotransverse joints ankylosis were evaluated...
2024: Therapeutic Advances in Musculoskeletal Disease
https://read.qxmd.com/read/38579351/impact-of-bilateral-facet-joint-violation-on-radiographic-degeneration-of-superior-adjacent-segments-and-clinical-outcomes
#32
JOURNAL ARTICLE
Zhiguo Ding, Derun Di, Lianlei Wang, Xinyu Liu
OBJECTIVE: Facet joint violation (FJV) is associated with postoperative low-back pain and is a confirmed risk factor for adjacent-segment degeneration, a long-term complication of lumbar fusion surgery. The authors' knowledge of its mechanisms comes from in vitro biomechanical research only; there is a lack of radiographic evidence of the effects of violation on the superior adjacent-segment facet joint, intervertebral disc, and other local radiographic parameters. Furthermore, any differences between unilateral and bilateral violation remain relatively unclear...
April 5, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38576506/delayed-unilateral-facet-interlocking-after-a-stable-superior-articular-process-fracture-of-the-cervical-spine-a-case-report
#33
Sejin Choi, Wonseok Lee, Jin-Deok Joo, Jong Kook Rhim, You Nam Chung, Jisoon Huh
A 42-year-old man presented with neck pain after a fall from a tree. Spine computed tomography (CT) illustrated the right C5 superior articular process fracture without displacement. Magnetic resonance imaging (MRI) confirmed the fracture and injury of the posterior ligament complex. Initially he was managed conservatively with a neck brace as there were no signs of instability or vertebral body misalignment. However, three days after discharge, right shoulder weakness and numbness of the right upper arm became prominent...
March 2024: Korean Journal of Neurotrauma
https://read.qxmd.com/read/38570036/the-relationship-between-paraspinal-muscle-atrophy-and-degenerative-lumbar-spondylolisthesis-at-the-l4-5-level
#34
JOURNAL ARTICLE
Paul Köhli, Lukas Schönnagel, Jan Hambrecht, Jiaqi Zhu, Erika Chiapparelli, Ali E Güven, Gisberto Evangelisti, Krizia Amoroso, Roland Duculan, Bernhard Michalski, Jennifer Shue, Koki Tsuchiya, Marco D Burkhard, Andrew A Sama, Federico P Girardi, Frank P Cammisa, Carol A Mancuso, Alexander P Hughes
BACKGROUND/CONTEXT: Degenerative lumbar spondylolisthesis (DLS) is a prevalent spinal condition that can result in significant disability. DLS is thought to result from a combination of disc and facet joint degeneration, as well as various biological, biomechanical, and behavioral factors. One hypothesis is the progressive degeneration of segmental stabilizers, notably the paraspinal muscles, contributes to a vicious cycle of increasing slippage. PURPOSE: To examine the correlation between paraspinal muscle status on MRI and severity of slippage in patients with symptomatic DLS...
April 1, 2024: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/38568281/traumatic-thoracic-spine-fracture-can-we-predict-when-mri-would-modify-the-fracture-classification-or-decision-making-compared-to-ct-alone
#35
JOURNAL ARTICLE
Khulood K AlRaddadi, Abdulbaset M Al-Shoaibi, Abdelwahed Alnaqeep, Waleed Almohamady, Meshari M Almutairi, Mohamed AbdelAziz, Mohamed M Aly
PURPOSE: To determine the impact of magnetic resonance imaging (MRI) on fracture classification for thoracic spine fractures (TSFs) compared to computed tomography (CT) alone. METHODS: This study was a retrospective review of 63 consecutive patients with TSFs who underwent CT and MRI within ten days of injury. Three reviewers classified all fractures according to the AOSpine Classification and the Thoracolumbar AOSpine Injury severity score (TLAOSIS). Posterior ligamentous complex (PLC) injury on MRI was defined by "black stripe discontinuity" and on CT by the presence of vertebral body translation, facet joint malalignment, horizontal laminar or spinous process fracture, and interspinous widening...
April 3, 2024: European Spine Journal
https://read.qxmd.com/read/38567006/surgical-tactics-of-two-segmental-cervical-degenerative-diseases-risk-factors-retrospective-assessment-and-preoperative-planning
#36
JOURNAL ARTICLE
Vadim A Byvaltsev, Andrei A Kalinin, Alexander V Kuharev, Nurzhan O Azhibekov, Marat A Aliyev
BACKGROUND: Currently, in the specialized literature there are no substantiated clinical and radiological indications for differentiated use of anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF) in the treatment of patients with two-segmental cervical degenerative diseases. The objectives of this study were to (I) identify risk factors that were associated with unsatisfactory results of two-level ACDF and one-level ACCF in the treatment of patients with cervical degenerative diseases despite current perioperative management, and (II) develop a clinical and radiological algorithm for personalized surgical tactics...
March 20, 2024: Journal of Spine Surgery (Hong Kong)
https://read.qxmd.com/read/38561837/biomechanical-response-of-decompression-alone-in-lower-grade-lumbar-degenerative-spondylolisthesis-a-finite-element-analysis
#37
JOURNAL ARTICLE
Renfeng Liu, Tao He, Xin Wu, Wei Tan, Zuyun Yan, Youwen Deng
BACKGROUND: Previous studies have demonstrated the clinical efficacy of decompression alone in lower-grade spondylolisthesis. A higher rate of surgical revision and a lower rate of back pain relief was also observed. However, there is a lack of relevant biomechanical evidence after decompression alone for lower-grade spondylolisthesis. PURPOSE: Evaluating the biomechanical characteristics of total laminectomy, hemilaminectomy, and facetectomy for lower-grade spondylolisthesis by analyzing the range of motion (ROM), intradiscal pressure (IDP), annulus fibrosus stress (AFS), facet joints contact force (FJCF), and isthmus stress (IS)...
April 1, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38561033/what-are-the-risk-factors-for-residual-pain-after-percutaneous-vertebroplasty-or-kyphoplasty-a-meta-analysis
#38
JOURNAL ARTICLE
Tao Zhang, Yinghu Deng, Zhongshan Yuan, Minghao Zhou, Zhixiang Ma, Mingkai Zhang
BACKGROUND: Although many risk factors for residual pain following percutaneous vertebroplasty or kyphoplasty have been reported in many studies, research methods and cohorts differ greatly. A previous meta-analysis identified patient- and operation-specific risk factors for residual pain. This study aimed to examine the available data and identify significant risk factors for residual pain after percutaneous vertebroplasty or kyphoplasty. METHODS: PubMed, EMBASE, Web of Science, and the Chinese Wanfang Database were searched for relevant research in English and Chinese, and full-text publications including patients with and without residual pain were compared...
March 30, 2024: World Neurosurgery
https://read.qxmd.com/read/38557428/a-novel-guide-device-for-pedicle-screw-insertion-using-three-dimensional-preoperative-planning-in-open-lumbar-spinal-surgery-a-comparative-retrospective-study
#39
JOURNAL ARTICLE
Hüseyin Doğu, Anas Abdallah
OBJECTIVE: Pedicle screw stabilization (PSS) surgeries for spinal instability are still the most effective treatment approach. The use of preoperative planning can minimize the complications related to transpedicular screw (TPS) misplacement. The study aimed to evaluate the surgical outcomes of a guide device developed to improve the accuracy of the free-hand technique using three-dimensional planning in PSS. PATIENTS AND METHODS: Patients with degenerative spinal diseases who underwent open PSS between 2019 and 2022 were evaluated retrospectively...
April 1, 2024: Neurological Research
https://read.qxmd.com/read/38557261/the-importance-of-medial-patellar-shape-as-a-risk-factor-for-recurrent-patellar-dislocation-in-adults
#40
JOURNAL ARTICLE
Frances T Sheehan, Paras Shah, Barry P Boden
BACKGROUND: Research on the cause of lateral patellar dislocation (LPD) has focused on trochlear morphologic parameters, joint alignment, and patellofemoral soft tissue forces. A paucity of information is available regarding how patellar morphologic parameters influence the risk for LPD. PURPOSE/HYPOTHESIS: The purpose was to assess whether patellar morphology is a risk factor for recurrent LPD. It was hypothesized that (1) patients with recurrent LPD would have decreased patellar width and volume and (2) patellar morphologic parameters would accurately discriminate patients with recurrent LPD from controls...
April 2024: American Journal of Sports Medicine
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