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https://www.readbyqxmd.com/read/27904835/a-novel-dominant-d109a-cryab-mutation-in-a-family-with-myofibrillar-myopathy-affects-%C3%AE-b-crystallin-structure
#1
Jakub P Fichna, Anna Potulska-Chromik, Przemysław Miszta, Maria Jolanta Redowicz, Anna M Kaminska, Cezary Zekanowski, Sławomir Filipek
Myofibrillar myopathy (MFM) is a group of inherited muscular disorders characterized by myofibrils dissolution and abnormal accumulation of degradation products. So far causative mutations have been identified in nine genes encoding Z-disk proteins, including αB-crystallin (CRYAB), a small heat shock protein (also called HSPB5). Here, we report a case study of a 63-year-old Polish female with a progressive lower limb weakness and muscle biopsy suggesting a myofibrillar myopathy, and extra-muscular multisystemic involvement, including cataract and cardiomiopathy...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/26480256/-lactic-acidosis-acute-renal-failure-and-heart-failure-during-treatment-with-metformin-what-do-we-know
#2
Anna Mudoni, Francesco Caccetta, Maurizio Caroppo, Fernando Musio, Antonella Accogli, Maria Dolores Zacheo, Maria Domenica Burzo, Riccardo Nuzzo, Vitale Nuzzo
Metformin is a common medication used for the treatment of type 2 diabetes, especially in obese subjects. Clinical studies show that, in addition to the lowering effect of blood glucose, metformin reduces cardiovascular risk, does not induce weight gain and additionally, provides a unique safety strategy and efficacy in patients with diabetes and heart disease. However, this treatment is not without risks. The most feared metabolic complication is lactic acidosis that often occurs with complex and severe clinical symptoms and is associated with a high mortality risk...
September 2015: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/26294204/broken-heart-as-work-related-accident-occupational-stress-as-a-cause-of-takotsubo-cardiomyopathy-in-55-year-old-female-teacher-role-of-automated-function-imaging-in-diagnostic-workflow
#3
Agnieszka Mielczarek, Jarosław Damian Kasprzak, Andrzej Marcinkiewicz, Małgorzata Kurpesa, Barbara Uznańska-Loch, Karina Wierzbowska-Drabik
Takotsubo cardiomiopathy (TTC) (known also as "ampulla cardiomyopathy," "apical ballooning" or "broken heart syndrome") is connected with a temporary systolic left ventricular dysfunction without the culprit coronary lesion. Takotsubo cardiomyopathy was first described in 1990 in Japan after octopus trapping pot with a round bottom and narrow neck similar in shape to left ventriculogram in TTC patients. The occurrence of TTC is usually precipitated by a stressful event with a clinical presentation mimicking myocardial infarction: chest pain, ST-T segment elevation or T-wave inversion, a rise in cardiac troponin, and contractility abnormalities in echocardiography...
2015: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/26039025/-symptoms-and-treatment-of-radiation-induced-reactions
#4
REVIEW
Anna Brzozowska, Magdalena Idziak, Franciszek Burdan, Maria Mazurkiewicz
Radiotherapy is one of the main methods of cancer treatment alone or in combination with chemotherapy. It is applied in about 60% of oncological patients. However, in spite of its clinical usefulness, radiotherapy is associated with a high risk of radiation-induced side effects, including dermatitis, enteritis, cystitis, pericarditis, pneumonia or depression, sexual function disorders, cardiomiopathy, coronary heart disease, anomalies of heart valves and development of second malignant tumor. The early diagnosis and proper treatment of radiation-induced side effects have a major impact on patients` quality of life and future prognosis...
May 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/25625721/multipoint-pacing-by-a-left-ventricular-quadripolar-lead-improves-the-acute-hemodynamic-response-to-crt-compared-with-conventional-biventricular-pacing-at-any-site
#5
Francesco Zanon, Enrico Baracca, Gianni Pastore, Lina Marcantoni, Chiara Fraccaro, Daniela Lanza, Claudio Picariello, Silvio Aggio, Loris Roncon, Fabio Dell'Avvocata, GianLuca Rigatelli, Domenico Pacetta, Franco Noventa, Frits W Prinzen
BACKGROUND: Response to cardiac resynchronization therapy (CRT) remains challenging. Pacing from multiple sites of the left ventricle (LV) has shown promising results. OBJECTIVE: The purpose of this study was to systematically compare the acute hemodynamic effects of multipoint pacing (MPP) by means of a quadripolar lead with conventional biventricular (BiV) pacing. METHODS: Twenty-nine patients (23 men; mean age 72 ± 12 years; LV ejection fraction 29% ± 7%; 15 with ischemic cardiomyopathy, 17 with left bundle branch block; mean QRS 183 ± 23 ms) underwent CRT implantation...
May 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/25502927/profile-of-trypanosoma-cruzi-infection-in-a-tropical-medicine-reference-center-northern-italy
#6
Federico Gobbi, Andrea Angheben, Mariella Anselmi, Chiara Postiglione, Ernestina Repetto, Dora Buonfrate, Stefania Marocco, Stefano Tais, Andrea Chiampan, Paride Mainardi, Zeno Bisoffi
BACKGROUND: Chagas disease (CD) is endemic in Central and South America, Mexico and even in some areas of the United States. However, cases have been increasingly recorded also in non-endemic countries. The estimated number of infected people in Europe is in a wide range of 14000 to 181000 subjects, mostly resident in Spain, Italy and the United Kingdom. METHODOLOGY/PRINCIPAL FINDINGS: Retrospective, observational study describing the characteristics of patients with CD who attended the Centre for Tropical Diseases (Negrar, Verona, Italy) between 2005 and 2013...
December 2014: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25158888/results-with-syncardia-total-artificial-heart-beyond-1-year
#7
MULTICENTER STUDY
Gianluca Torregrossa, Michiel Morshuis, Robin Varghese, Leila Hosseinian, Vladimiro Vida, Vincenzo Tarzia, Antonio Loforte, Daniel Duveau, Francisco Arabia, Pascal Leprince, Vigneshwa Kasirajan, Friedhelm Beyersdorf, Francesco Musumeci, Roland Hetzer, Thoamas Krabatsch, Jan Gummert, Jack Copeland, Gino Gerosa
Mechanical circulatory support devices have been increasingly used for long-term support. We reviewed outcomes in all patients supported with a SynCardia total artificial heart (TAH) for more than 1 year to assess its safety in long-term support. As of December 2011, all 47 patients who received the TAH from 10 centers worldwide were included in this retrospective study. Clinical data were collected on survival, infections, thromboembolic and hemorrhagic events, device failures, and antithrombotic therapy. The mean age of patients was 50 ± 1...
November 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24918671/-stress-takotsubo-cardiomyopathy-in-a-patient-with-anorexia-nervosa
#8
Sabrina Vadalá, Débora Pellegrini, María Fernanda Verdaguer, Marcela Schrappe, José Alvarez, Julio E Bruetman
We report the case of a woman with anorexia nervosa who developed takotsubo cardiomyopathy triggered by emotional stress and electrolyte disturbances. The patient improved with conservative management. Descriptions of stress-cardiomyopathy in association with eating disorders are often of higher severity and related to QT prolongation because of electrolyte abnormalities, ventricular arrhythmias and hypoglycemia. A review of cardiovascular compromise in patients with anorexia nervosa is performed.
2014: Medicina
https://www.readbyqxmd.com/read/24791211/a-rare-case-of-ocular-myositis
#9
Carmen Valeria Albu, B Cătălin, Cornelia Zaharia
We report the case of a 43 year old man who presented recurrent left abducens palsy. His medical history included arterial hypertension, ischemic cardiomiopathy, dyslipidemia, rhinitis, maxillary sinusitis. Physical examination revealed a overweight patient, horizontal gaze diplopia, left nerve VI paresis, mild left retro-orbital pain. The orbital MRI also didn't offer new information: mild external edema on the left eye, with normal tendon aspect, no thickening or enhancement of the muscle belly and also normal aspect of the bony orbit...
January 2014: Current Health Sciences Journal
https://www.readbyqxmd.com/read/24776047/functional-improvement-in-patients-with-dilated-cardiomyopathy-after-the-intracoronary-infusion-of-autologous-bone-marrow-mononuclear-cells
#10
José Suárez de Lezo, Concepción Herrera, Miguel Romero, Manuel Pan, Javier Suárez de Lezo, María Dolores Carmona, Rosario Jiménez, José Segura, Sonia Nogueras, Dolores Mesa, Djordje Pavlovic, Soledad Ojeda, Francisco Mazuelos, Mónica Delgado, Martin Ruiz, María Luisa Castilla, Antonio Torres
INTRODUCTION AND OBJECTIVES: Different studies have shown improvement in patients with idiopathic nonischemic dilated cardiomyopathy treated with cell-therapy. However, factors influencing responsiveness are not well known. This trial investigates functional changes and factors influencing the 6-month gain in ejection fraction in 27 patients with dilated cardiomiopathy treated with intracoronary cell-therapy. METHODS: Patients received intracoronary infusion of autologous bone-marrow mononuclear cells (mean infused, 10...
June 2013: Revista Española de Cardiología
https://www.readbyqxmd.com/read/24575643/-parameters-of-cardiac-pacing-and-effectiveness-of-defibrillation-during-implantable-cardioverter-defibrillator-lead-implantation-to-right-ventricle-outflow-tract
#11
Anna Rydlewska, Jakub Machejek, Anna Engel, Jacek Lelakowski
UNLABELLED: Traditional implantation site for implantable cardioverter-defibrillator (ICD) is right ventricular apex (RVA). According to many data, this location ensures low enough defibrillation threshold. ICDs are more often implanted in patients with impaired left ventricle function, in whom, along with disease progression, the need for permanent stimulation develops. Right ventricle outflow tract (RVOT) is considered to be a better site for permanent stimulation. The aim of the study was to assess acute parameters of an ICD lead implantation to RVOT...
November 2013: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/24563797/rhabdomyolysis-and-cardiomyopathy-in-a-20-year-old-patient-with-cpt-ii-deficiency
#12
M Vavlukis, A Eftimov, P Zafirovska, E Caparovska, B Pocesta, S Kedev, A J Dimovski
Aim. To raise the awareness of adult-onset carnitite palmitoyltransferase II deficiency (CPT II) by describing clinical, biochemical, and genetic features of the disease occurring in early adulthood. Method. Review of the case characteristics and literature review. Results. We report on a 20-year-old man presenting with dyspnea, fatigue, fever, and myoglobinuria. This was the second episode with such symptoms (the previous one being three years earlier). The symptoms occurred after intense physical work, followed by a viral infection resulting in fever treated with NSAIDs...
2014: Case Reports in Genetics
https://www.readbyqxmd.com/read/24066253/primary-angioplasty-for-cardiac-allograft-vasculopathy-presenting-as-st-elevation-acute-myocardial-infarction-during-endomyocardial-biopsy
#13
Bruno Ramos Nascimento, Thalles Oliveira Gomes, Júlio César Borges, Guilherme Rafael Sant'anna Athayde, Sílvio Amadeu de Andrade, Maria da Consolação Vieira Moreira
Cardiac allograft vasculopathy is still a major issue, with significative mortality in heart transplant patients, and the best therapeutic options are not yet established. The progressively higher survival rates after transplantation have made it a major concern. This is a case report about a patient who underwent cardiac transplantation due to chagasic cardiomiopathy. During an endomyocardial biopsy more than 2 years after the transplant, the patient arrested in ventricular fibrillation, with ST-elevation in anterior leads after defibrillation...
2013: Case Reports in Transplantation
https://www.readbyqxmd.com/read/23809661/erectile-dysfunction-penile-atherosclerosis-and-coronary-artery-vasculopathy-in-heart-transplant-recipients
#14
Nicola Caretta, Giuseppe Feltrin, Giuseppe Tarantini, Chiara D'Agostino, Francesco Tona, Mirko Schipilliti, Riccardo Selice, Nadia Minicuci, Gino Gerosa, Carlo Foresta
INTRODUCTION: Vascular erectile dysfunction (ED) is the expression of a systemic vascular disease and in particular of endothelial dysfunction. Dysfunctional endothelium plays also a significant role in the onset and progression of coronary artery vasculopathy (CAV). AIM: This pilot study was designed to evaluate the prevalence and pathogenesis of ED and its correlation with CAV in heart transplanted male. METHODS: A total of 77 male heart transplanted patients (HTx) evaluated in our center (mean age 61...
September 2013: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/23507582/functional-improvement-in-patients-with-dilated-cardiomyopathy-after-the-intracoronary-infusion-of-autologous-bone-marrow-mononuclear-cells
#15
José Suárez de Lezo, Concepción Herrera, Miguel Romero, Manuel Pan, Javier Suárez de Lezo, María Dolores Carmona, Rosario Jiménez, José Segura, Sonia Nogueras, Dolores Mesa, Djordje Pavlovic, Soledad Ojeda, Francisco Mazuelos, Mónica Delgado, Martin Ruiz, María Luisa Castilla, Antonio Torres
INTRODUCTION AND OBJECTIVES: Different studies have shown improvement in patients with idiopathic nonischemic dilated cardiomyopathy treated with cell-therapy. However, factors influencing responsiveness are not well known. This trial investigates functional changes and factors influencing the 6-month gain in ejection fraction in 27 patients with dilated cardiomiopathy treated with intracoronary cell-therapy. METHODS: Patients received intracoronary infusion of autologous bone-marrow mononuclear cells (mean infused, 10...
June 2013: Revista Española de Cardiología
https://www.readbyqxmd.com/read/23093320/celiac-disease-prevalence-in-children-and-adolescents-with-myocarditis-and-dilated-cardiomiopathy
#16
Thaysa Maria Gama Albuquerque Leão de Menezes, Maria Eugênia Farias Almeida Motta
OBJECTIVE: To determine the prevalence of celiac disease in patients with myocarditis and dilated cardiomyopathy. METHODS: Fifty-six patients between 1 and 18 years old with dilated cardiomyopathy or myocarditis were evaluated and followed up at Instituto de Medicina Integral Professor Fernando Figueira. Patients with previous diagnosis of celiac disease were excluded. The functional classification was determined according to the American Heart Association criteria (classes I, II, III and IV)...
September 2012: Jornal de Pediatria
https://www.readbyqxmd.com/read/23077895/expression-of-extracellular-markers-as-criteria-for-treatment-of-peripheral-arterial-occlusive-disease
#17
Setalia Popa, M D Datcu
UNLABELLED: During the last decade, mesenchymal stromal cells (MSC) have been used in medical therapeutics, especially for reperfusion in peripheral arterial disease, ischemic cardiomiopathy and myocardial infarction. Studies demonstrated that membrane proteins are important in MSC endothelial differentiation. AIM: To determine the expression of extracellular markers of MSC, in order to ascertain if some expressed proteins (MSC specific cluster of differentiation proteins, essential for MSC characterization and proteins which have a role in adhesion and migration) have capability to induce angiogenesis...
January 2012: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/22958907/cardiac-dysfunction-in-cirrhosis-is-not-associated-with-the-severity-of-liver-disease
#18
COMPARATIVE STUDY
Manuela Merli, Angela Calicchia, Alessandra Ruffa, Pierpaolo Pellicori, Oliviero Riggio, Michela Giusto, Carlo Gaudio, Concetta Torromeo
BACKGROUND: Cirrhotic cardiomiopathy is described as the presence of cardiac dysfunction in cirrhotic patients. The aim of the study was to investigate factors associated with cardiac dysfunction in cirrhotic patients. PATIENTS AND METHODS: Seventy-four cirrhotic patients and twenty-six controls performed a conventional echocardiography and Tissue Doppler Imaging (TDI) for systolic and diastolic function. Results were analyzed by using the Guidelines of American Society of Echocardiography...
March 2013: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/22916617/-heart-transplant-program-at-the-umae-general-hospital-dr-gaudencio-gonz%C3%A3-lez-garza-of-the-la-raza-national-medical-center
#19
Guillermo Careaga-Reyna, Hugo Zetina-Tun, Carlos Alberto Lezama-Urtecho
BACKGROUND: The heart transplantation has modified the life expectancy of patients with terminal heart failure. OBJECTIVE: To present our experience in heart transplantation. MATERIAL AND METHODS: A retrospective cohort study was realized for heart transplant recipients between July 21, 1988 and May 30, 2011. We evaluated the procedure for evaluation and selection of heart donors and heart transplant recipients. Also we reviewed etiology of cardiomiopathy, age and gender of patients, surgical procedure, and postoperative evolution, immediate and long-term survival...
September 2011: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/22891561/-antitachyarrhythmic-interventions-of-implantable-cardioverter-defibrillator-in-primary-and-secondary-sudden-cardiac-death-prevention-patients
#20
Justyna Piekarz, Anna Rydlewska, Jacek Majewski, Jacek Lelakowski
UNLABELLED: Antitachycardia pacing (ATP) and high voltage interventions (CV) are methods of interrupting dangerous ventricular arrhythmias. The aim of the study was to determine the frequency of ventricular tachyarrhythmias and form of ICD interventions in patients in the primary and secondary sudden cardiac death (SCD) prevention groups. MATERIAL AND METHODS: The study involved 399 patients (334 male, 65 female), mean age was 65.2 +/- 12.1 years (21-89 years), who had an ICD implanted in years 2008-2010...
June 2012: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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