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https://www.readbyqxmd.com/read/27900088/favorable-control-of-advanced-colon-adenocarcinoma-with-severe-bone-marrow-metastasis-a-case-report
#1
Fumiyasu Hanamura, Yoshihiro Shibata, Tsuyoshi Shirakawa, Miyuki Kuwayama, Hisanobu Oda, Hiroshi Ariyama, Kenichi Taguchi, Taito Esaki, Eishi Baba
Colorectal cancer (CRC) has a propensity to metastasize to the liver, lungs and regional abdominal lymph nodes, but rarely to the bone marrow. A 60-year-old man presented to the National Hospital Organization Kyushu Cancer Center with a 4-week history of persistent lower back pain, anorexia and difficulty defecating. Complete blood count revealed severe thrombocytopenia and erythroblastosis, suggesting a hematological malignancy. However, the bone marrow examination demonstrated involvement by a moderately to poorly differentiated adenocarcinoma, but no hematopoietic abnormalities...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896350/characterizing-the-optical-properties-of-single-palladium-coated-core-shell-gold-nanorods-as-multifunctional-orientation-probes
#2
So Young Lee, Ji Won Ha
Bimetallic core-shell gold nanorods are promising multifunctional orientation probes due to the synergetic effect of two different metals, as examined under an optical microscope. Herein, we performed a single particle study to characterize the optical properties of palladium-coated core-shell gold nanorods (Pd-AuNRs) using scattering-based dark-field (DF) and differential interference contrast (DIC) microscopy, and to examine their use as multifunctional orientation probes in biological and physical studies...
November 29, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27895713/coexistence-of-iamp21-and-etv6-runx1-fusion-in-an-adolescent-with-b-cell-acute-lymphoblastic-leukemia-literature-review-of-six-additional-cases
#3
Jun Gu, Alexandra Reynolds, Lianghua Fang, Corrie DeGraffenreid, Kenneth Sterns, Keyur P Patel, L Jeffrey Medeiros, Pei Lin, Xinyan Lu
BACKGROUND: Intrachromosomal amplification of chromosome 21 (iAMP21) results from breakage-fusion-bridge cycles and chromothripsis is a distinct marker of a subgroup of B cell acute lymphoblastic leukemia (B-ALL) cases associated with a poor prognosis. iAMP21 accounts for 2% of pediatric B-ALL and occurs predominantly in older children or adolescents. ETV6-RUNX1 fusion, resulting from t(12;21)(p13;q22), is associated with an excellent outcome in younger children with B-ALL. Coexistence of iAMP21 with ETV6-RUNX1 fusion is extremely rare with limited clinical information available...
2016: Molecular Cytogenetics
https://www.readbyqxmd.com/read/27893946/predicting-animal-home-range-structure-and-transitions-using-a-multistate-ornstein-uhlenbeck-biased-random-walk
#4
Greg A Breed, Emily A Golson, M Tim Tinker
The home-range concept is central in animal ecology and behavior, and numerous mechanistic models have been developed to understand home range formation and maintenance. These mechanistic models usually assume a single, contiguous home range. Here we describe and implement a simple home-range model that can accommodate multiple home-range centers, form complex shapes, allow discontinuities in use patterns, and infer how external and internal variables affect movement and use patterns. The model assumes individuals associate with two or more home-range centers and move among them with some estimable probability...
October 6, 2016: Ecology
https://www.readbyqxmd.com/read/27893739/evaluating-carbonate-system-algorithms-in-a-nearshore-system-does-total-alkalinity-matter
#5
Jonathan M Jones, Julia Sweet, Mark A Brzezinski, Heather M McNair, Uta Passow
Ocean acidification is a threat to many marine organisms, especially those that use calcium carbonate to form their shells and skeletons. The ability to accurately measure the carbonate system is the first step in characterizing the drivers behind this threat. Due to logistical realities, regular carbonate system sampling is not possible in many nearshore ocean habitats, particularly in remote, difficult-to-access locations. The ability to autonomously measure the carbonate system in situ relieves many of the logistical challenges; however, it is not always possible to measure the two required carbonate parameters autonomously...
2016: PloS One
https://www.readbyqxmd.com/read/27878654/coating-polypropylene-surfaces-with-protease-weakens-the-adhesion-and-increases-the-dispersion-of-candida-albicans-cells
#6
Eugenio Spadoni Andreani, Federica Villa, Francesca Cappitelli, Anna Krasowska, Piotr Biniarz, Marcin Łukaszewicz, Francesco Secundo
OBJECTIVES: To investigate the ability of the proteases, subtilisin and α-chymotrypsin (aCT), to inhibit the adhesion of Candida albicans biofilm to a polypropylene surface. RESULTS: The proteases were immobilized on plasma-treated polypropylene by covalently linking them with either glutaraldehyde (GA) or N'-diisopropylcarbodiimide (DIC) and N-hydroxysuccinimide (NHS). The immobilization did not negatively affect the enzyme activity and in the case of subtilisin, the activity was up to 640% higher than that of the free enzyme when using N-acetyl phenylalanine ethyl ester as the substrate...
November 23, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27868334/consensus-on-the-standardization-of-terminology-in-thrombotic-thrombocytopenic-purpura-and-related-thrombotic-microangiopathies
#7
M Scully, S Cataland, P Coppo, J de la Rubia, K D Friedman, J Kremer Hovinga, B Lämmle, M Matsumoto, K Pavenski, E Sadler, R Sarode, H Wu
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are two important acute conditions to diagnose. Thrombotic Microangiopathy is a broad pathophysiological process that leads to microangiopathic hemolytic anemia, thrombocytopenia and involves capillary and small vessel platelet aggregates. The most common cause being disseminated intravascular coagulation (DIC), which may be differentiated by abnormal coagulation. Clinically, a number of conditions present with microangiopathic hemolytic anemia and thrombocytopenia (MAHAT), including cancer, infection, transplantation, drugs, autoimmune disease and pre-eclampsia and HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome in pregnancy...
November 21, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27861900/abiotic-influences-on-bicarbonate-use-in-the-giant-kelp-macrocystis-pyrifera-in-the-monterey-bay
#8
Sarah Tepler Drobnitch, Kerry Nickols, Matthew Edwards
In the Monterey Bay region of Central California, the giant kelp Macrocystis pyrifera experiences broad fluctuations in wave forces, temperature, light availability, nutrient availability, and seawater carbonate chemistry, all of which may impact their productivity. In particular, current velocities and light intensity may strongly regulate the supply and demand of inorganic carbon (Ci) as substrates for photosynthesis. M. pyrifera can acquire and utilize both CO2 and bicarbonate (HCO3(-) ) as Ci substrates for photosynthesis and growth; given the variability of carbon delivery (due to current velocities and varying [DIC]) and demand (in the form of saturating irradiance) we hypothesized that the proportion of CO2 and bicarbonate utilized is not constant for M...
November 11, 2016: Journal of Phycology
https://www.readbyqxmd.com/read/27861597/comparison-of-two-diagnostic-scores-of-disseminated-intravascular-coagulation-in-pregnant-women-admitted-to-the-icu
#9
Marie Jonard, Anne Sophie Ducloy-Bouthors, François Fourrier
OBJECTIVE: To compare the validity of two previously published diagnostic scores of disseminated intravascular coagulation (DIC) in pregnant women admitted to ICU for an acute thrombotic or hemorrhagic complication of delivery and postpartum. METHODS: This was a population based retrospective study of 154 patients admitted to ICU for severe delivery and postpartum complications in a University Hospital. A recently published score (adapted to physiological changes of pregnancy and based on three components: platelet count, prothrombin time difference and fibrinogen) was compared to the International Society for Thrombosis and Hemostasis (ISTH) score (based on four components: platelet count, fibrinogen, prothrombin time, and fibrin related marker)...
2016: PloS One
https://www.readbyqxmd.com/read/27854087/spontaneous-intracranial-hypotension-complicated-by-malignancyinduced-disseminated-intravascular-coagulation-a-case-report
#10
Hung-Yi Wu, Shu-Shya Hseu, Shih-Pin Chen, Jiing-Feng Lirng, Yen-Feng Wang, Shuu-Jiun Wang, Jong-Ling Fuh
PURPOSE: Spontaneous intracranial hypotension (SIH) is a rare type of headache. The association of SIH with malignancy and disseminated intravascular coagulation (DIC) has not previously been reported. CASE REPORT: A 60-year-old woman had orthostatic headache for more than one month before admission. MRI of brain showed diffuse pachymeningeal enhancement with bilateral subdural hematoma. MR myelography revealed epidural fluid collection and possible CSF leakage at the level of C5 to C6...
September 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27853388/efficacy-tolerability-and-safety-of-an-oral-enzyme-combination-vs-diclofenac-in-osteoarthritis-of-the-knee-results-of-an-individual-patient-level-pooled-reanalysis-of-data-from-six-randomized-controlled-trials
#11
Michael A Ueberall, Gerhard Hh Mueller-Schwefe, Rainer Wigand, Ute Essner
OBJECTIVE: To compare efficacy, safety, and tolerability of an oral enzyme combination (OEC) containing proteolytic enzymes and bioflavonoid vs diclofenac (DIC), a nonselective nonsteroidal anti-inflammatory drug in the treatment of osteoarthritis of the knee. MATERIALS AND METHODS: This was an individual patient-level pooled reanalysis of patient-reported data from prospective, randomized, double-blind, parallel-group studies in adult patients with moderate-to-severe osteoarthritis of the knee treated for at least 3 weeks with OEC or DIC...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27851929/construction-and-characterization-of-a-pure-protein-hydrogel-for-drug-delivery-application
#12
Xu Xu, ZhaoKang Xu, XiaoFeng Yang, YanHao He, Rong Lin
Injectable hydrogels have a variety of applications, including regenerative medicine, tissue engineering and controlled drug delivery. In this paper, we reported on a pure protein hydrogel based on tetrameric recombinant proteins for the potential drug delivery application. This protein hydrogel was formed instantly by simply mixing two recombinant proteins (ULD-TIP1 and ULD-GGGWRESAI) through the specific protein-peptide interaction. The protein hydrogel was characterized by rheology and scanning electron microscopy (SEM)...
November 13, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27851018/1382-interaction-between-dic-and-sofa-scores-in-prediction-of-prognosis-and-final-outcome-in-the-icu
#13
Mahmoud Nour, Ahmed Rostom, Mohamed Afify, Ahmed Elsherif
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27844439/simultaneous-manipulation-and-super-resolution-fluorescence-imaging-of-individual-kinetochores-coupled-to-microtubule-tips
#14
Yi Deng, Charles L Asbury
Kinetochores are large multiprotein complexes that drive mitotic chromosome movements by mechanically coupling them to the growing and shortening tips of spindle microtubules. Kinetochores are also regulatory hubs, somehow sensing when they are erroneously attached and, in response, releasing their incorrect attachments and generating diffusible wait signals to delay anaphase until proper attachments can form. The remarkable ability of a kinetochore to sense and respond to its attachment status might stem from attachment- or tension-dependent changes in the structural arrangement of its core subcomplexes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27832332/a-successfully-treated-case-of-cardiac-arrest-after-caesarean-section-complicated-by-pheochromocytoma-crisis-and-amniotic-fluid-embolism
#15
Kenichiro Mita, Kayo Tsugita, Yoshikazu Yasuda, Yasunari Matsuki, Yurie Obata, Yuka Matsuki, Seiichi Kamisawa, Kenji Shigemi
Both pheochromocytoma and amniotic fluid embolism (AFE) are important causes of maternal mortality. We present a case of a 29-year-old woman who developed cardiac arrest after Caesarean section, complicated by both pheochromocytoma crisis and AFE. After resuscitation, the patient developed multiple organ dysfunction, rhabdomyolysis and disseminated intravascular coagulation (DIC). After institution of multidisciplinary interventions (including the use of an intra-aortic balloon pump, extracorporeal membrane oxygenation, continuous hemodiafiltration, and neuroprotective therapeutic hypothermia) the patient made a full recovery without any apparent neurological deficit...
November 10, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27828064/three-dimensional-displacement-measurement-based-on-the-combination-of-digital-image-correlation-and-optical-flow
#16
Fei Xiao, Ran Zhao, Ping Sun
This paper proposes what we believe is a novel simultaneous three-dimensional (3D) displacement measurement technique based on a combination of digital image correlation (DIC) and optical flow (OF). In this method, both the in-plane and out-of-plane displacements can be accurately extracted from only two continuous interferograms. DIC estimates the velocity field between two consecutive frames. According to the optical flow constrained equation, we can then obtain the whole-field out-of-plane displacement map by the estimations of the in-plane displacement components and the local frequency of the original image...
October 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27823669/an-effective-microfluidic-based-liquid-phase-microextraction-device-%C3%AE-lpme-for-extraction-of-non-steroidal-anti-inflammatory-drugs-from-biological-and-environmental-samples
#17
María Ramos-Payan, Santiago Maspoch, Andreu Llobera
In this work, the traditional liquid phase microextraction (LPME) has been miniaturized into a microfluidic device (μLPME) where liquid phase microextraction is combined with an HPLC procedure. This integration enables extraction and determination of acid drugs by μLPME and HPLC, respectively. The analytes selected for the test are five widely used non-steroidal anti-inflammatory drugs (NSAIDs): salicylic acid (SAC), ketoprofen (KTP), naproxen (NAX), diclofenac (DIC) and ibuprofen (IBU). They have successfully been detected in biological (urine and saliva) and environmental (lake and river water) samples with excellent clean up, high extraction efficiency and good enrichment factor under stopped-flow conditions...
November 23, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27818655/prokaryotic-responses-to-ammonium-and-organic-carbon-reveal-alternative-co2-fixation-pathways-and-importance-of-alkaline-phosphatase-in-the-mesopelagic-north-atlantic
#18
Federico Baltar, Daniel Lundin, Joakim Palovaara, Itziar Lekunberri, Thomas Reinthaler, Gerhard J Herndl, Jarone Pinhassi
To decipher the response of mesopelagic prokaryotic communities to input of nutrients, we tracked changes in prokaryotic abundance, extracellular enzymatic activities, heterotrophic production, dark dissolved inorganic carbon (DIC) fixation, community composition (16S rRNA sequencing) and community gene expression (metatranscriptomics) in 3 microcosm experiments with water from the mesopelagic North Atlantic. Responses in 3 different treatments amended with thiosulfate, ammonium or organic matter (i.e., pyruvate plus acetate) were compared to unamended controls...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27803823/massive-bleeding-as-the-first-clinical-manifestation-of-metastatic-prostate-cancer-due-to-disseminated-intravascular-coagulation-with-enhanced-fibrinolysis
#19
Mónica Palma Anselmo, Gustavo Nobre de Jesus, João Madeira Lopes, Rui M M Victorino, João Meneses Santos
Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with metastatic prostate adenocarcinoma. However, DIC with enhanced fibrinolysis as an initial presentation of prostate cancer is extremely rare. The appropriate treatment to control bleeding in these situations is challenging, controversial, and based on isolated case reports in the literature. A 66-year-old male presented at the emergency department with acute severe spontaneous ecchymoses localized to the limbs, laterocervical hematoma, and hemothorax...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27802870/an-integrated-guidance-and-control-approach-in-three-dimensional-space-for-hypersonic-missile-constrained-by-impact-angles
#20
Xiaodong Liu, Wanwei Huang, Lifu Du
A new robust three-dimensional integrated guidance and control (3D-IGC) approach is investigated for sliding-to-turn (STT) hypersonic missile, which encounters high uncertainties and strict impact angle constraints. First, a nonlinear state-space model with more generality is established facing to the design of 3D-IGC law. With regard to the as-built nonlinear system, a robust dynamic inversion control (RDIC) approach is proposed to overcome the robustness deficiency of traditional DIC, and then it is applied to construct the basic 3D-IGC law combining with backstepping method...
October 29, 2016: ISA Transactions
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