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https://www.readbyqxmd.com/read/28448007/a-novel-biaxial-testing-apparatus-for-the-determination-of-forming-limit-under-hot-stamping-conditions
#1
Zhutao Shao, Nan Li
The hot stamping and cold die quenching process is increasingly used to form complex shaped structural components of sheet metals. Conventional experimental approaches, such as out-of-plane and in-plane tests, are not applicable to the determination of forming limits when heating and rapid cooling processes are introduced prior to forming for tests conducted under hot stamping conditions. A novel in-plane biaxial testing system was designed and used for the determination of forming limits of sheet metals at various strain paths, temperatures, and strain rates after heating and cooling processes in a resistance heating uniaxial testing machine...
April 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447577/prognostic-value-of-adamts13-in-patients-with-severe-sepsis-and-septic-shock
#2
M Feroz Azfar, M Faisal Khan, S Shahid Habib, Z Al Aseri, A Mohammad Zubaidi, D Ocampo Aguila, M Owais Suriya, Hameed Ullah
PURPOSE: ADAMTS13 level was evaluated as a predictor of mortality in patients with severe sepsis and septic shock, and compared with Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. METHODS: This prospective observational study was conducted in the Medical and Surgical Intensive Care Units of King Khalid University Hospital. Detailed clinical evaluations were performed on 84 patients (56.08±18.18 years of age) with severe sepsis and septic shock...
April 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28446901/anaerobic-methanotrophic-archaea-of-the-anme-2d-cluster-are-active-in-a-low-sulfate-iron-rich-freshwater-sediment
#3
Hannah S Weber, Kirsten S Habicht, Bo Thamdrup
ANaerobic MEthanotrophic (ANME) archaea remove the greenhouse gas methane from anoxic environments and diminish its flux to the atmosphere. High methane removal efficiencies are well documented in marine environments, whereas anaerobic oxidation of methane (AOM) was only recently indicated as an important methane sink in freshwater systems. Freshwater AOM-mediating microorganisms lack taxonomic identification and only little is known about metabolic adaptions to prevailing biogeochemical conditions. One of the first study sites providing information about AOM activity in freshwater sediment is Lake Ørn, a low-sulfate, iron-rich Danish lake...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28442711/temperature-dependent-fracture-properties-of-shape-memory-alloys-novel-findings-and-a-comprehensive-model
#4
Carmine Maletta, Emanuele Sgambitterra, Fabrizio Niccoli
Temperature dependent fracture properties of NiTi-based Shape Memory Alloys (SMAs), within the pseudoelastic regime, were analyzed. In particular, the effective Stress Intensity Factor (SIF) was estimated, at different values of the testing temperature, by a fitting of the William's expansion series, based on Digital Image Correlation (DIC) measurements. It was found that temperature plays an important role on SIF and on critical fast fracture conditions. As a consequence, Linear Elastic Fracture Mechanics (LEFM) approaches are not suitable to predict fracture properties of SMAs, as they do not consider the effects of temperature...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28442312/expert-statements-on-the-standard-of-care-in-critically-ill-adult-patients-with-atypical-haemolytic-uraemic-syndrome
#5
REVIEW
Elie Azoulay, Paul Knoebl, José Garnacho-Montero, Katerina Rusinova, Gennadii Galstian, Philippe Eggimann, Fekri Abroug, Dominique Benoit, Michael von Bergwelt-Baildon, Julia Wendon, Marie Scully
BACKGROUND: Atypical haemolytic uraemic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP), and other causes or conditions with thrombotic microangiopathy (TMA) such as DIC or sepsis. Similarity in clinical presentation may hinder diagnosis and optimal treatment selection in the urgent setting in the ICU. However, there is currently no consensus on the diagnosis or treatment of aHUS for ICU specialists. This review aims to summarise available data on the diagnosis and treatment strategies of aHUS in the ICU in order to enhance the understanding of aHUS diagnosis and outcomes in patients managed in the ICU...
April 22, 2017: Chest
https://www.readbyqxmd.com/read/28437856/microstructure-variations-in-the-soft-hard-tissue-junction-of-the-human-anterior-cruciate-ligament
#6
Lei Zhao, Peter V Lee, David C Ackland, Neil D Broom, Ashvin Thambyah
The role of the sub-bundles in the anterior cruciate ligament (ACL) has been defined, such that the anterior-medial bundle directly resists anterior tibial translation while the posterior lateral bundle is involved in rotational stability. With regards to this biomechanical function, much of the previous work on bundle-specific morphology has been carried out on the macro-scale, with much less attention given to the micro-to-ultrastructural scalar levels. This is especially true of the enthesis and its microstructure, a biomechanically significant region that has been largely neglected in the published literature dealing with ACL sub-bundle anatomy...
April 24, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28422420/a-study-of-disseminated-intravascular-coagulation-in-acute-leukemia-reveals-markedly-elevated-d-dimer-levels-are-a-sensitive-indicator-of-acute-promyelocytic-leukemia
#7
N Shahmarvand, J S Oak, M J Cascio, M Alcasid, E Goodman, B C Medeiros, D A Arber, J L Zehnder, R S Ohgami
INTRODUCTION: While the presence of disseminated intravascular coagulation (DIC) has been implicated in worse clinical outcome in acute leukemia, the relationship between different subtypes of acute leukemia and the clinicopathologic features of DIC has not been systematically well studied. METHODS: In this study, we retrospectively reviewed 149 cases of newly diagnosed acute leukemia and assessed the utility of evaluating red blood cell morphologic features, and coagulation parameters in determining the presence of DIC as well as differentiating subtypes of acute leukemia...
April 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28420841/tranexamic-acid-controlled-chronic-disseminated-intravascular-coagulation-associated-with-aortic-dissection-and-patent-false-lumen-for-three-years
#8
Yodo Gatate, Nobuyuki Masaki, Atsushi Sato, Risako Yasuda, Takayuki Namba, Hirotaka Yada, Akio Kawamura, Takeshi Adachi
The management of chronic disseminated intravascular coagulation (DIC) caused by aortic dissection has not yet been established. Even in cases where surgical correction is performed, therapeutic control of systemic hemorrhaging is still required. We herein report the successful treatment of a case of aortic dissection with a patent false lumen using tranexamic acid for acute exacerbation of chronic DIC. Oral administration of 1,500 mg tranexamic acid per day stabilized the coagulative and fibrinolytic parameters and relieved bleeding tendencies with no side effects...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28420603/the-coags-uncomplicated-app-fulfilling-educational-gaps-around-diagnosis-and-laboratory-testing-of-coagulation-disorders
#9
Craig Kessler, Ellinor I Peerschke, Meera B Chitlur, Roshni Kulkarni, Natalia Holot, David L Cooper
BACKGROUND: Patients with coagulation disorders may present to a variety of physician specialties; however, accurate and efficient diagnosis can be challenging for physicians not specialized in hematology, due to identified gaps in knowledge around appropriate laboratory assays and interpretation of test results. Coags Uncomplicated was developed to fill this unmet educational need by increasing practical knowledge of coagulation disorders among nonexpert physicians and other health care professionals (HCPs) in a point-of-care (POC) setting...
April 18, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28412927/widespread-subcutaneous-necrosis-in-spotted-fever-group-rickettsioses-from-the-coastal-belt-of-sri-lanka-a-case-report
#10
Nathasha Luke, Hasini Munasinghe, Lakshmi Balasooriya, Ranjan Premaratna
BACKGROUND: Spotted fever group rickettsioses (SFGR) transmitted mostly by ticks are increasingly discovered around the World and some of them are either re-emerging or emerging in Sri Lanka. Accidental human infections caused by these vector borne zoonotic diseases generally give rise to nonspecific acute febrile illnesses which can be complicated by multi organ involvement carrying high morbidity and mortality. Nonspecific clinical features and non-availability of early diagnostic facilities are known to result in delay in the diagnosis of rickettsial infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28400101/overcoming-the-exacerbating-effects-of-ranitidine-on-nsaid-induced-small-intestinal-toxicity-with-quercetin-providing-a-complete-gi-solution
#11
Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar
There is a need to find/discover novel leads to treat complex and/or multi-factorial-pathogenic disease(s) like Nonsteroidal anti-inflammatory drugs (NSAID)-induced gastroenteropathy or gastrointestinal (GI) toxicity as it has emerged as an important medical and socioeconomic problem. There is no approved therapeutic strategy to prevent NSAID-induced small intestinal toxicity and highly effective gastro-protective drugs such as ranitidine hydrochloride (RAN) exacerbate it. In this purview, the multi target drug discovery approach (MTDD), combination approach and hit to lead strategies based on the foundation of ethnopharmacology and/or reverse pharmacology holds strong potential...
April 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28398591/evolutionarily-distinct-strategies-for-the-acquisition-of-inorganic-carbon-from-seawater-in-marine-diatoms
#12
Yoshinori Tsuji, Anggara Mahardika, Yusuke Matsuda
The acquisition of dissolved inorganic carbon (DIC) in CO2-limited seawater is a central issue to understand in marine primary production. We previously demonstrated the occurrence of direct HCO3- uptake by solute carrier (SLC) 4 transporters in a diatom, a major marine primary producer. Homologs of SLC are found in both centric and pennate marine diatoms, suggesting that SLC transporters are generally conserved. Here, the generality of SLC-mediated DIC uptake in diatoms was examined using an SLC inhibitor, diisothiocyano-2,2'-stilbenedisulfonic acid (DIDS), and an inhibitor of external carbonic anhydrase, acetazolamide...
April 8, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28391356/rat-precision-cut-liver-slices-predict-drug-induced-cholestatic-injury
#13
Viktoriia Starokozhko, Rick Greupink, Petra van de Broek, Nashwa Soliman, Samiksha Ghimire, Inge A M de Graaf, Geny M M Groothuis
Drug-induced cholestasis (DIC) is one of the leading manifestations of drug-induced liver injury (DILI). As the underlying mechanisms for DIC are not fully known and specific and predictive biomarkers and pre-clinical models are lacking, the occurrence of DIC is often only reported when the drug has been approved for registration. Therefore, appropriate models that predict the cholestatic potential of drug candidates and/or provide insight into the mechanism of DIC are highly needed. We investigated the application of rat precision-cut liver slices (PCLS) to predict DIC, using several biomarkers of cholestasis: hepatocyte viability, intracellular accumulation of total as well as individual bile acids and changes in the expression of genes known to play a role in cholestasis...
April 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28386413/threshold-effect-of-growth-rate-on-population-variability-of-escherichia-coli-cell-lengths
#14
Manasi S Gangan, Chaitanya A Athale
A long-standing question in biology is the effect of growth on cell size. Here, we estimate the effect of Escherichia coli growth rate (r) on population cell size distributions by estimating the coefficient of variation of cell lengths (CVL) from image analysis of fixed cells in DIC microscopy. We find that the CVL is constant at growth rates less than one division per hour, whereas above this threshold, CVL increases with an increase in the growth rate. We hypothesize that stochastic inhibition of cell division owing to replication stalling by a RecA-dependent mechanism, combined with the growth rate threshold of multi-fork replication (according to Cooper and Helmstetter), could form the basis of such a threshold effect...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28383305/a-digital-image-correlation-analysis-of-strain-generated-by-3-unit-implant-supported-fixed-dental-prosthesis-an-in-vitro-study
#15
Raniel F Peixoto, Ana P Macedo, Janisse Martinelli, Adriana C Lapria Faria, Rodrigo Tiossi, Ricardo F Ribeiro, Maria da G C de Mattos
OBJECTIVE: To evaluate the influence of different veneering materials (porcelain and resin) and implants (short and conventional) in the strain distribution of implant-supported splinted fixed partial dentures (FPDs) using digital image correlation (DIC). MATERIAL AND METHODS: Four polyurethane models were fabricated with resin replicas (first premolar) and short and/or conventional implants replacing the second premolar and first and second molars, according to the following configurations: G1, 2 conventional (second premolar and first molar) and 1 short (second molar) implant; G2, 1 conventional (second premolar) and 2 short (first and second molar) implants; G3, 3 short implants; G4, 3 conventional implants...
April 5, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28380862/phase-shifted-helical-long-period-fiber-grating-and-its-characterization-by-using-the-microscopic-imaging-method
#16
Peng Wang, Ramanathan Subramanian, Chengliang Zhu, Hua Zhao, Hongpu Li
We demonstrate a simple and robust method to write a phase-shifted helical long-period fiber grating (HLPG), where an equivalent phase-shift is formed by changing the local period of the grating during the fabrication process. Furthermore, we propose and demonstrate a simple method to characterize the phase-shift formed in a HLPG, which is realized by directly analyzing the imaging pattern of the fabricated HLPG using a stereo microscope under a white light illumination. Unlike the previous methods which are indirectly realized either by measuring the transmission spectrum of the fabricated HLPG or by analyzing the differential interference contrast (DIC) microscopic images of the fabricated HLPG, the proposed method can be used to well estimate the grating period as well as the phase-shift inserted in the HLPG in situ, which could considerably facilitate the fabrication technique of the HLPG by using CO<sub>2</sub> laser...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28375008/the-dynameomics-entropy-dictionary-a-large-scale-assessment-of-conformational-entropy-across-protein-fold-space
#17
Clare-Louise Towse, Mikael Akke, Valerie Daggett
Molecular dynamics (MD) simulations contain considerable information with regard to the motions and fluctuations of a protein, the magnitude of which can be used to estimate conformational entropy. Here we survey conformational entropy across protein fold space using the Dynameomics database, which represents the largest existing data set of protein MD simulations for representatives of essentially all known protein folds. We provide an overview of MD-derived entropies accounting for all possible degrees of dihedral freedom on an unprecedented scale...
April 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28371723/in-vitro-drug-interaction-of-levocetirizine-and-diclofenac-theoretical-and-spectroscopic-studies
#18
Ahmed S Abo Dena, Sara A Abdel Gaber
Levocetirizine dihydrochloride is known to interact with some anti-inflammatory drugs. We report here a comprehensive integrated theoretical and experimental study for the in vitro drug interaction between levocetirizine dihydrochloride (LEV) and diclofenac sodium (DIC). The interaction of the two drugs was confirmed by the molecular ion peak obtained from the mass spectrum of the product. Moreover, FTIR and (1)HNMR spectra of the individual drugs and their interaction product were inspected to allocate the possible sites of interaction...
March 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28369501/in-synechococcus-sp-competition-for-energy-between-assimilation-and-acquisition-of-c-and-those-of-n-only-occurs-when-growth-is-light-limited
#19
Zuoxi Ruan, John A Raven, Mario Giordano
The carbon-concentrating mechanisms (CCMs) of cyanobacteria counteract the low CO2 affinity and CO2:O2 selectivities of the Rubisco of these photolithotrophs and the relatively low oceanic CO2 availability. CCMs have a significant energy cost; if light is limiting, the use of N sources whose assimilation demands less energy could permit a greater investment of energy into CCMs and inorganic C (Ci) assimilation. To test this, we cultured Synechococcus sp. UTEX LB 2380 under either N or energy limitation, in the presence of NO3- or NH4+...
March 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28368336/serum-concentrations-of-angiopoietin-2-and-soluble-fms-like-tyrosine-kinase-1-sflt-1-are-associated-with-coagulopathy-among-patients-with-acute-pancreatitis
#20
Paulina Dumnicka, Beata Kuśnierz-Cabala, Mateusz Sporek, Małgorzata Mazur-Laskowska, Krzysztof Gil, Marek Kuźniewski, Piotr Ceranowicz, Zygmunt Warzecha, Artur Dembiński, Joanna Bonior, Ryszard Drożdż
In severe acute pancreatitis (SAP), systemic inflammation leads to endothelial dysfunction and activation of coagulation. Thrombotic disorders in acute pancreatitis (AP) include disseminated intravascular coagulation (DIC). Recently, angiopoietin-2 and soluble fms-like tyrosine kinase 1 (sFlt-1) were proposed as markers of endothelial dysfunction in acute states. Our aim was to assess the frequency of coagulation abnormalities in the early phase of AP and evaluate the relationships between serum angiopoietin-2 and sFlt-1 and severity of coagulopathy...
April 2, 2017: International Journal of Molecular Sciences
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