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https://www.readbyqxmd.com/read/29650593/human-neural-stem-cell-extracellular-vesicles-improve-recovery-in-a-porcine-model-of-ischemic-stroke
#1
Robin L Webb, Erin E Kaiser, Brian J Jurgielewicz, Samantha Spellicy, Shelley L Scoville, Tyler A Thompson, Raymond L Swetenburg, David C Hess, Franklin D West, Steven L Stice
BACKGROUND AND PURPOSE: Recent work from our group suggests that human neural stem cell-derived extracellular vesicle (NSC EV) treatment improves both tissue and sensorimotor function in a preclinical thromboembolic mouse model of stroke. In this study, NSC EVs were evaluated in a pig ischemic stroke model, where clinically relevant end points were used to assess recovery in a more translational large animal model. METHODS: Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO), and either NSC EV or PBS treatment was administered intravenously at 2, 14, and 24 hours post-MCAO...
April 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29649706/quantitative-assessment-for-flexed-elbow-deformity-during-gait-following-botulinum-toxin-a-treatment
#2
Hiroki Tanikawa, Hitoshi Kagaya, Keisuke Inagaki, Yusuke Kotsuji, Keita Suzuki, Kenta Fujimura, Masahiko Mukaino, Satoshi Hirano, Eiichi Saitoh, Yoshikiyo Kanada
BACKGROUND: The effect of botulinum toxin A (BoNTA) injection on flexed-elbow deformity is usually evaluated using the Modified Ashworth Scale (MAS), but only with the muscle tone at rest. Some patients show the flexed-elbow deformity during gait despite low muscle tone at rest. OBJECTIVE: This study aimed to evaluate the effect of BoNTA injection on flexed-elbow deformity during gait using a three-dimensional motion analysis system. METHODS: Twenty stroke patients with spastic flexed-elbow deformity during gait received BoNTA injections into the upper limb muscles...
April 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29649054/the-effect-of-a-single-textured-insole-in-gait-rehabilitation-of-individuals-with-stroke
#3
Alexander S Aruin, Noel Rao
Rehabilitation interventions designed to restore gait symmetry in individuals with stroke are not always effective. The goal was to evaluate the long-term effect of using a single textured insole in gait rehabilitation. Ten individuals with stroke who showed asymmetrical stance were randomly divided into two groups and participated in physical therapy. Individuals in the experimental group received a 6-week physical therapy while being provided with a textured insole in the shoe on the unaffected side. Individuals in the control group received a 6-week physical therapy only...
April 11, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29643608/the-immediate-effect-of-fes-and-tens-on-gait-parameters-in-patients-after-stroke
#4
Shin-Jun Park, Joong-San Wang
[Purpose] This study was conducted to compare the immediate effects of different electrotherapies on the gait parameters for stroke patients. [Subjects and Methods] Thirty patients with stroke were randomly assigned either to the functional electrical stimulation group or the transcutaneous electrical nerve stimulation group, with 15 patients in each group. Each electrotherapy was performed for 30 minutes simultaneously with the therapeutic exercise, and the changes in the spatial and temporal parameters of gait were measured...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29643598/effects-of-gait-training-on-sand-on-improving-the-walking-ability-of-patients-with-chronic-stroke-a-randomized-controlled-trial
#5
Tae-Ho Kim, Byoung-Ha Hwang
[Purpose] This study examines how difference in sandy ground between firm ground influences the effects of gait training in patients with chronic stroke. [Subjects and Methods] A total of 28 patients with chronic stroke were evenly divided into experimental and control groups. Initial evaluation of the subjects was conducted by Timed Up & Go (TUG) and 6-Minute Walking Test (6MWT). Each patient in both groups received daily, 30-minute gait training on sandy ground and firm ground, five times each week, for a total of six weeks, after which reevaluation was conducted...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29627608/effect-of-wheelchair-stroke-pattern-on-upper-extremity-muscle-fatigue
#6
Brittany Bickelhaupt, Sakiko Oyama, Jonathan Benfield, Keith Burau, Shuko Lee, Michelle Trbovich
BACKGROUND: Shoulder dysfunction is common in persons with spinal cord injury (SCI) with an incidence of up to 63%1 . Dysfunction is a result of muscle imbalances, specifically denervated rotator cuff muscles that are repetitively used during manual wheelchair propulsion. OBJECTIVE: To determine which arm stroke technique, pump (P) or semicircular (SC), is most energy efficient for long periods of propulsion. DESIGN: A small randomized study with repeated-measures observations...
April 5, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29627499/pelvic-excursion-during-walking-post-stroke-a-novel-classification-system
#7
Virginia L Little, Theresa E McGuirk, Lindsay A Perry, Carolynn Patten
BACKGROUND: Researchers and clinicians often use gait speed to classify hemiparetic gait dysfunction because it offers clinical predictive capacity. However, gait speed fails to distinguish unique biomechanical characteristics that differentiate aspects of gait dysfunction. RESEARCH QUESTION: Here we describe a novel classification of hemiparetic gait dysfunction based on biomechanical traits of pelvic excursion. We hypothesize that individuals with greater deviation of pelvic excursion, relative to controls, demonstrate greater impairment in key gait characteristics...
March 31, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29625628/advanced-robotic-therapy-integrated-centers-artic-an-international-collaboration-facilitating-the-application-of-rehabilitation-technologies
#8
Hubertus J A van Hedel, Giacomo Severini, Alessandra Scarton, Anne O'Brien, Tamsin Reed, Deborah Gaebler-Spira, Tara Egan, Andreas Meyer-Heim, Judith Graser, Karen Chua, Daniel Zutter, Raoul Schweinfurther, J Carsten Möller, Liliana P Paredes, Alberto Esquenazi, Steffen Berweck, Sebastian Schroeder, Birgit Warken, Anne Chan, Amber Devers, Jakub Petioky, Nam-Jong Paik, Won-Seok Kim, Paolo Bonato, Michael Boninger
BACKGROUND: The application of rehabilitation robots has grown during the last decade. While meta-analyses have shown beneficial effects of robotic interventions for some patient groups, the evidence is less in others. We established the Advanced Robotic Therapy Integrated Centers (ARTIC) network with the goal of advancing the science and clinical practice of rehabilitation robotics. The investigators hope to exploit variations in practice to learn about current clinical application and outcomes...
April 6, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29625414/regulation-of-quasi-joint-stiffness-by-combination-of-activation-of-ankle-muscles-in-midstances-during-gait-in-patients-with-hemiparesis
#9
Yusuke Sekiguchi, Takayuki Muraki, Dai Owaki, Keita Honda, Shin-Ichi Izumi
BACKGROUND: The regulation of ankle joint stiffness by combination of activation of plantarflexor and dorsiflexor during gait has not been investigated in patients with hemiparesis. The objective of the present study was to examine the relationship between combination of activation of ankle muscles and quasi-joint stiffness (QJS) during the stance phase of gait. METHODS: The activation of the medial head of the gastrocnemius (MG), soleus, and tibialis anterior, gait parameters were collected from 19 patients with hemiparesis due to stroke and from 12 healthy controls using a three-dimensional motion analysis system...
March 28, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29622624/relationship-between-dual-task-gait-speed-and-walking-activity-poststroke
#10
Jody A Feld, Lisa A Zukowski, Annie G Howard, Carol A Giuliani, Lori J P Altmann, Bijan Najafi, Prudence Plummer
BACKGROUND AND PURPOSE: Gait speed does not adequately predict whether stroke survivors will be active in the community. This may be because traditional single-task gait speed does not sufficiently reproduce the demands of walking in the real world. This study assessed whether dual-task gait speed accounts for variance in daily ambulatory activity above what can be predicted with habitual (single task) gait speed in community-dwelling stroke survivors. METHODS: Twenty-eight community-dwelling individuals, 58...
April 5, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29615890/automatic-setting-procedure-for-exoskeleton-assisted-overground-gait-proof-of-concept-on-stroke-population
#11
Marta Gandolla, Eleonora Guanziroli, Andrea D'Angelo, Giovanni Cannaviello, Franco Molteni, Alessandra Pedrocchi
Stroke-related locomotor impairments are often associated with abnormal timing and intensity of recruitment of the affected and non-affected lower limb muscles. Restoring the proper lower limbs muscles activation is a key factor to facilitate recovery of gait capacity and performance, and to reduce maladaptive plasticity. Ekso is a wearable powered exoskeleton robot able to support over-ground gait training. The user controls the exoskeleton by triggering each single step during the gait cycle. The fine-tuning of the exoskeleton control system is crucial-it is set according to the residual functional abilities of the patient, and it needs to ensure lower limbs powered gait to be the most physiological as possible...
2018: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29610039/botulinum-toxin-type-a-treatment-combined-with-intensive-rehabilitation-for-gait-poststroke-a-preliminary-study
#12
Yuki Uchiyama, Tetsuo Koyama, Yosuke Wada, Masashi Katsutani, Norihiko Kodama, Kazuhisa Domen
GOAL: To examine the effects of botulinum toxin type A (BoNT-A) treatment combined with intensive rehabilitation for gait compared with intensive rehabilitation alone in patients with chronic stroke. MATERIALS AND METHODS: A comparative case series design was used. Subjects were 19 patients with chronic stroke and spastic hemiplegia. In 9 patients (group I), BoNT-A was injected into spastic muscles of the affected lower limbs, followed by a 4-week inpatient intensive rehabilitation program...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29604488/prefrontal-over-activation-during-walking-in-people-with-mobility-deficits-interpretation-and-functional-implications
#13
Kelly A Hawkins, Emily J Fox, Janis J Daly, Dorian K Rose, Evangelos A Christou, Theresa E McGuirk, Dana M Otzel, Katie A Butera, Sudeshna A Chatterjee, David J Clark
BACKGROUND: Control of walking by the central nervous system includes contributions from executive control mechanisms, such as attention and motor planning resources. Executive control of walking can be estimated objectively by recording prefrontal cortical activity using functional near infrared spectroscopy (fNIRS). OBJECTIVE: The primary objective of this study was to investigate group differences in prefrontal/executive control of walking among young adults, older adults, and adults post-stroke...
March 28, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29600688/early-robot-assisted-gait-retraining-in-non-ambulatory-patients-with-stroke-a-single-blind-randomized-controlled-trial
#14
Andreas Mayr, Ellen Quirbach, Alessandro Picelli, Markus Kofler, Nicola Smania, Leopold Saltuari
BACKGROUND: Restoration of walking function is a primary concern of neurorehabilitation with respect to the aspired social and vocational reintegration. To date, the best practice for improving gait early after stroke is still object of debate. On one hand, repetitive task-specific approaches with higher intensities of walking have been observed to result in greater improvements of gait after stroke. Conversely there is some evidence that conventional gait training would be more effective for facilitating walking ability after stroke...
March 29, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29593921/unilateral-asterixis-in-arm-and-leg-caused-by-internal-capsula-stroke
#15
Katharina Feil, Marion Huber, Nicolina Goldschagg, Lars Kellert
We report an unusual clinical manifestation of ischemic stroke with acute right-sided asterixis affecting the arm as well as the leg due to a lesion in the left posterior limb of the internal capsula. After treatment with intravenous thrombolysis the patient made a good recovery. Notably, in this case unilateral asterixis affected the arm as well as the leg, resulting in postural and gait instability. In addition, damage in the basal ganglia-thalamo-cortical network, as in our patient, has to be distinguished from other supratentorial causes of acute asterixis like thalamic or frontal lobe lesions linked to the cerebello-brainstem-thalamo-frontal lobe circuits...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29589777/mirror-therapy-and-treadmill-training-for-a-patient-with-chronic-stroke-a-case-report
#16
Patrick Broderick, Frances Horgan, Catherine Blake, Paula Hickey, Joanne O'Reilly, Monika Ehrensberger, Daniel Simpson, David Roberts, Kenneth Monaghan
INTRODUCTION: A large proportion of patients with chronic stroke have permanent lower limb functional disability leading to reduced levels of independent mobility. Individually, both mirror therapy and treadmill training have been shown to improve aspects of lower limb functioning in patients with stroke. This case report examined whether a new combination of both interventions would lead to improvements in lower limb functional disability for a patient with chronic stroke. CASE DESCRIPTION: The participant was a 50-year-old female who had a left middle cerebral artery infarction (47 months' post stroke)...
March 28, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29588151/strength-of-the-lower-limb-and-trunk-muscles-is-associated-with-gait-speed-in-individuals-with-sub-acute-stroke-a-cross-sectional-study
#17
Larissa Tavares Aguiar, Ludimylla Brennar Alves Camargo, Lorena Dasdores Estarlino, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria
OBJECTIVES: To investigate the association between measures of strength of the lower limb and trunk muscles and gait speed and to identify the muscle group that would best predict gait speed in individuals with sub-acute stroke. METHODS: Using a cross-sectional observational study design, forty-four individuals with sub-acute stroke (62 years, SD=14; 4 months, SD=1 post-stroke) were assessed. The evaluations were performed at a university laboratory, participants' homes, or community-based settings...
March 15, 2018: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29587833/use-of-hybrid-assistive-limb-hal-%C3%A2-for-a-postoperative-patient-with-cerebral-palsy-a-case-report
#18
Yuki Mataki, Hiroshi Kamada, Hirotaka Mutsuzaki, Yukiyo Shimizu, Ryoko Takeuchi, Masafumi Mizukami, Kenichi Yoshikawa, Kazushi Takahashi, Mayumi Matsuda, Nobuaki Iwasaki, Hiroaki Kawamoto, Yasuyoshi Wadano, Yoshiyuki Sankai, Masashi Yamazaki
BACKGROUND: The Hybrid Assistive Limb (HAL® ) is an exoskeleton wearable robot suit that assists in voluntary control of knee and hip joint motion. There have been several studies on HAL intervention effects in stroke, spinal cord injury, and cerebral palsy. However, no study has investigated HAL intervention for patients with cerebral palsy after surgery. CASE PRESENTATION: We report a case of using HAL in a postoperative patient with cerebral palsy. A 15-year-old boy was diagnosed with spastic diplegia cerebral palsy Gross Motor Function Classification System level IV, with knee flection contracture, equinus foot, and paralysis of the right upper extremity with adduction contracture...
March 27, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29587246/effect-of-different-designs-of-ankle-foot-orthoses-on-gait-in-patients-with-stroke-a-systematic-review
#19
REVIEW
Aliyeh Daryabor, Mokhtar Arazpour, Gholamreza Aminian
BACKGROUND: Ankle foot orthoses (AFOs) are used to improve the gait of patients with stroke. RESEARCH QUESTION: The current review aimed at evaluating the efficacy of different designs of AFOs and comparison between them on the gait parameters of individuals with hemiplegic stroke. METHODS: The search strategy was based on the population intervention comparison outcome (PICO) method. A search was performed in PubMed, ISI Web of Knowledge, Scopus, Science Direct, and Google Scholar databases...
March 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29571875/familial-and-sporadic-chronic-progressive-degenerative-parietal-ataxia
#20
Ryuta Morihara, Toru Yamashita, Kentaro Deguchi, Tomoko Kurata, Emi Nomura, Kota Sato, Yumiko Nakano, Yasuyuki Ohta, Nozomi Hishikawa, Takeshi Ikeuchi, Masataka Kitaguchi, Koji Abe
BACKGROUND & OBJECTIVE: Parietal ataxia has been mainly reported as a consequence of acute ischemic stroke, while degenerative parietal ataxia has not been reported. METHODS: We investigated clinical characteristics, neuroimaging data, and genetic analysis of patients with cerebellar ataxia plus parietal atrophy. RESULTS: We identified seven patients, including five patients from two families, with chronic progressive cerebellar ataxia due to degenerative parietal atrophy but not stroke...
April 15, 2018: Journal of the Neurological Sciences
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