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Ming Yang, Amy K Hara, Ba D Nguyen, Michael C Roarke
No abstract text is available yet for this article.
May 27, 2017: Digestive and Liver Disease
Kathleen Weyts, Meike Vernooij, Rebecca Steketee, Roelf Valkema, Marion Smits
18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85-0.86, p<0.05). Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement...
May 19, 2017: Clinical Imaging
Sarit Appel, Yaacov R Lawrence, Jeffery Goldstein, Raphael M Pfeffer, Ilana Weiss, Tatiana Rabin, Shira Felder, Maoz Ben-Ayun, Lev Tzvang, Dror Alezra, David Simansky, Alon Ben-Nun, Jair Bar, Zvi Symon
BACKGROUND: Stereotactic ablative radiation therapy (SABR) is the application of a very high radiation dose to a small treatment volume. It is the new standard of care in medically inoperable early-stage lung cancer. OBJECTIVES: To report the outcomes of SABR in stage I lung cancer at Sheba Medical Center since its introduction in 2009. METHODS: We conducted a retrospective chart review of patients with stage I lung cancer treated during the period 2009-2015...
January 2017: Israel Medical Association Journal: IMAJ
Peng-Fan Yang, Ming-Chao Shang, Qiao Lin, Hui Xiao, Zhen Mei, Yan-Zeng Jia, Wei Liu, Zhong-Hui Zhong
Magnetic resonance imaging (MRI)-negative epilepsy is associated with poor clinical outcomes prognosis. The present study was aimed to assess whether intracranial 3D interictal and ictal electroencephalography (EEG) findings, a combination of EEG at a different depth, in addition to clinical, scalp EEG, and positron emission tomography-computed tomography (PETCT) data help to predict outcome in a series of patients with MRI-negative frontal lobe epilepsy (FLE) after surgery.Patients with MRI-negative FLE who were presurgically evaluated by 3D-intracranial EEG (3D-iEEG) recording were included...
December 2016: Medicine (Baltimore)
Ming Young Simon Wan, Raymond Endozo, Sofia Michopoulou, Robert Shortman, Manuel Rodriguez-Justo, Leon Menezes, Syed Yusuf, Toby Richards, Damian Wild, Beatrice Waser, Jean Claude Reubi, Ashley Groves
(68)Ga-labeled somatostatin receptor ligand PET imaging has recently been shown in preclinical and early human studies to have a potential role in the evaluation of vulnerable arterial plaques. We prospectively evaluated carotid plaque (68)Ga-DOTATATE uptake in patients with recent carotid events, assessed inter- and intraobserver variability of such measurements, and explored the mechanism of any plaque DOTATATE activity with immunohistochemistry in resected specimens. Methods: Twenty consecutively consenting patients with recent symptomatic carotid events (transient ischemic attack, stroke, or amaurosis fugax), due for carotid endarterectomy, were prospectively recruited...
May 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Padma Subramanyam, Shanmuga Sundaram Palaniswamy, Anshu Tewari
Cutaneous metastasis may be the first evidence of internal malignancy or a sign of recurrence of malignancy and is considered a grave prognostic sign. There are various morphological variants of cutaneous metastases, with the most common being solitary to multiple erythematous infiltrating papules and nodules and the rarer variants being carcinoma erysipeloides, carcinoma en cuirasse, carcinoma telangiectaticum, alopecia neoplastica, metastasis to the inframammary crease, and zosteriform pattern. FDG PETCT is an established imaging modality in the identification of an unknown primary malignancy and also has an important role in the therapeutic decision-making...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Efstathia Voulgari, Aristides Bakandritsos, Sotiris Galtsidis, Vassilis Zoumpourlis, Benjamin P Burke, Gonçalo S Clemente, Christopher Cawthorne, Stephen J Archibald, Jiři Tuček, Radek Zbořil, Vasiliki Kantarelou, Andreas Germanos Karydas, Konstantinos Avgoustakis
The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We investigated different poly(methacrylic acid)-g-poly(ethyleneglycol methacrylate) polymers as in situ coating agents for magnetite nanocrystallites. The obtained magnetic nano-assemblies were in turn thoroughly characterized for their structural, colloidal and physicochemical properties (drug loading capacity/release, magnetic field triggered drug release, cell uptake and localization) in order to select the best performing system...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Takahito Fujimori, Tadashi Watabe, Yasuo Iwamoto, Seiki Hamada, Motoki Iwasaki, Takenori Oda
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To investigate the prevalence, concomitance, and distribution of various types of ossification of the spinal ligaments in healthy subjects using computed tomography (CT). SUMMARY OF BACKGROUND DATA: CT has better diagnostic accuracy for ossification of the spinal ligaments compared to plain radiography. Currently there is no study that examines the prevalence of ossification of the spinal ligaments using whole spine CT scans...
November 1, 2016: Spine
Clare Beadsmoore, David Newman, Duncan MacIver, Davina Pawaroo
Cancer remains a leading cause of death in Canada and worldwide. Whilst advances in anatomical imaging to detect and monitor malignant disease have continued over the last few decades, limitations remain. Functional imaging, such as positron emission tomography (PET), has improved the sensitivity and specificity in detecting malignant disease. In combination with computed tomography (CT), PET is now commonly used in the oncology setting and is an integral part of many cancer patients' pathways. Although initially the CT component of the study was purely for attenuation of the PET imaging and to provide anatomical coregistration, many centers now combine the PET study with a diagnostic quality contrast enhanced CT to provide one stop staging, thus refining the patient's pathway...
November 2015: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
L Sun, W Hu, M Moyers, J Zhao, W Hsi
PURPOSE: Positron-emitting isotope distributions can be used for the image fusion of the carbon ion planning CT and online target verification PETCT, after radiation in the same decay period,the relationship between the same target volume and the SUV value of different every single fraction dose can be found,then the range of SUV for the radiation target could be decided.So this online range also can provide reference for the correlation and consistency in planning target dose verification and evaluation for the clinical trial...
June 2015: Medical Physics
Nisha Bhavani, Adlyne Reena Asirvatham, Kumar Kallur, Arun S Menon, Praveen V Pavithran, Vasantha Nair, Jayakumar R Vasukutty, Usha Menon, Harish Kumar
BACKGROUND: Tumour-induced osteomalacia (TIO) is a rare disorder characterized by hypophosphataemic osteomalacia caused by small mesenchymal tumours secreting fibroblast growth factor 23 (FGF 23). The most difficult part in the management of these patients is the localization of tumours causing TIO. OBJECTIVE: We describe the utility of Gallium (Ga)-68 DOTANOC PET/CT in the localization of tumours causing TIO. PATIENTS AND METHODS: The study was conducted in a single tertiary referral university teaching hospital in India...
January 2016: Clinical Endocrinology
P Crucitti, I F Gallo, G Santoro, G Mangiameli
AIM: The main purpose of our project was to evaluate the prevalence of lung cancer in high risk, asymptomatic individuals in addition to quantifying the rate of surgically resectable tumors, and evaluating the role of lung cancer with low dose computed tomography (LDCT) as a tool for lung cancer screening. METHODS: Between June 2011 and March 2014, 1500 volunteers at high risk for lung cancer were enrolled in our study and underwent LDCT in our institution. The subsequent diagnostic and therapeutic steps were planned in relation to the results emerging from LDCT...
December 2015: Minerva Chirurgica
Ruud G P M van Stiphout, Vincenzo Valentini, Jeroen Buijsen, Guido Lammering, Elisa Meldolesi, Johan van Soest, Lucia Leccisotti, Alessandro Giordano, Maria A Gambacorta, Andre Dekker, Philippe Lambin
PURPOSE: To develop and externally validate a predictive model for pathologic complete response (pCR) for locally advanced rectal cancer (LARC) based on clinical features and early sequential (18)F-FDG PETCT imaging. MATERIALS AND METHODS: Prospective data (i.a. THUNDER trial) were used to train (N=112, MAASTRO Clinic) and validate (N=78, Università Cattolica del S. Cuore) the model for pCR (ypT0N0). All patients received long-course chemoradiotherapy (CRT) and surgery...
November 2014: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Mariarosaria Incoronato, Peppino Mirabelli, Onofrio Catalano, Marco Aiello, Chiara Parente, Andrea Soricelli, Emanuele Nicolai
BACKGROUND: The aim of this study was to evaluate the value of CA15-3 for the diagnostic integration of molecular imaging findings performed with hybrid positron emission tomography and computed tomography (PETCT) technology. METHODS: We retrospectively selected 45 patients with a median age of 60 years (range 39-85 years) and a previous history of breast cancer (BC) who had already been treated with surgery and other treatments. Three measurements of CA15-3 were collected within 1 year before PETCT examination, at 6-9 months 3-6 months and 0-3 months before PETCT...
May 21, 2014: BMC Cancer
Jürgen F Schäfer, Sergios Gatidis, Holger Schmidt, Brigitte Gückel, Ilja Bezrukov, Christina A Pfannenberg, Matthias Reimold, Martin Ebinger, Jörg Fuchs, Claus D Claussen, Nina F Schwenzer
PURPOSE: To compare positron emission tomography (PET)/magnetic resonance (MR) imaging and PET/computed tomography (CT) for lesion detection and interpretation, quantification of fluorine 18 ((18)F) fluorodeoxyglucose (FDG) uptake, and accuracy of MR-based PET attenuation correction in pediatric patients with solid tumors. Materials and Methods This prospective study had local ethics committee and German Federal Institute for Drugs and Medical Devices approval. Written informed consent was obtained from all patients and legal guardians...
October 2014: Radiology
Neeti Madan Kapre, Jyoti Pralhad Dabholkar
To study the impact of Positron emission tomography (PET) and its incremental value in diagnosing an unknown primary tumour with secondaries in the head and neck; recurrent head and neck cancers (confirmation of suspected recurrences and re-staging); and staging of head and neck tumours. This was a prospective observational study where 60 patients of head and neck tumours under the clinical settings as described above were evaluated. Thorough clinical examination and necessary radiological and histopathological investigations were done...
January 2014: Indian Journal of Otolaryngology and Head and Neck Surgery
Shanmuga Sundaram Palaniswamy, Padma Subramanyam
The primary clinical application of (18)F FDG PET/CT ((18)Fluorine labeled flurodeoxyglucose positron emission tomography/computed tomography) in differentiated thyroid carcinoma is in the identification of active disease in thyroglobulin (Tg) positive (>10 ng/ml), whole body iodine scan negative patients. The impact of FDG PET/CT in diagnosis, surveillance, cure, and progression-free survival of differentiated thyroid carcinoma patients remains to be seen. Five main indications of FDG PET/CT in thyroid cancer have been recommended by revised American thyroid association guidelines 2009...
October 2013: Annals of Nuclear Medicine
Thomas D Westwood, Celia Hogan, Peter J Julyan, Glyn Coutts, Suzie Bonington, Bernadette Carrington, Ben Taylor, Saye Khoo, Alec Bonington
BACKGROUND AND PURPOSE: In HIV infected patients, MRI cannot reliably differentiate between central nervous system (CNS) lymphoma and non-malignant CNS lesions, particularly cerebral toxoplasmosis (CTOX). This study prospectively investigates the utility of FDG PET-CT and magnetic resonance spectroscopy (MRS) in discriminating CNS lymphoma from non-malignant CNS lesions in HIV infected patients, and assesses the ability of FDG PET-CT to guide the use of early brain biopsy. METHODS: 10 HIV patients with neurological symptoms and contrast enhancing lesions on MRI were commenced on anti-toxoplasmosis therapy before undergoing FDG PET-CT and MRS...
August 2013: European Journal of Radiology
Akira Tangoku, Yota Yamamoto, Yoshihito Furukita, Masakazu Goto, Masami Morimoto
Fluorodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) have become the gold standard for staging of esophageal cancer by detecting distant metastases, but metastatic lymph nodes are often difficult to diagnose from the size and standardized uptake value (SUV). If we compare the diagnostic performance of endoscopic ultrasonography (EUS), CT, and FDG-PET in staging of esophageal cancer, EUS is the most sensitive method to identify the detection of regional lymph node metastases, whereas CT and FDG-PET are more specific tests...
2012: Annals of Thoracic and Cardiovascular Surgery
Akira Tangoku, Yota Yamamoto, Yoshihito Furukita, Masakazu Goto, Masami Morimoto
Fluorodeoxyglucose-positron emission tomography (FDG-PET) and computed tomography (CT) have become the gold standard for staging of esophageal cancer by detecting distant metastases, but metastatic lymph nodes are often difficult to diagnose from the size and standardized uptake value (SUV). If we compare the diagnostic performance of endoscopic ultrasonography (EUS), CT, and FDG-PET in staging of esophageal cancer, EUS is the most sensitive method to identify the detection of regional lymph node metastases, whereas CT and FDG-PET are more specific tests...
May 31, 2012: Annals of Thoracic and Cardiovascular Surgery
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