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https://www.readbyqxmd.com/read/28706583/cardiac-damage-in-athlete-s-heart-when-the-supernormal-heart-fails
#1
REVIEW
Andreina Carbone, Antonello D'Andrea, Lucia Riegler, Raffaella Scarafile, Enrica Pezzullo, Francesca Martone, Raffaella America, Biagio Liccardo, Maurizio Galderisi, Eduardo Bossone, Raffaele Calabrò
Intense exercise may cause heart remodeling to compensate increases in blood pressure or volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle, but all heart chambers. Physiological cardiac modeling in athletes is associated with normal or enhanced cardiac function, but recent studies have documented decrements in left ventricular function during intense exercise and the release of cardiac markers of necrosis in athlete's blood of uncertain significance. Furthermore, cardiac remodeling may predispose athletes to heart disease and result in electrical remodeling, responsible for arrhythmias...
June 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28703272/left-ventricular-non-compaction-and-hypertrophic-cardiomyopathy-two-overlapping-diseases-or-two-manifestations-of-the-same-cardiomyopathy-response-to-the-letter-concerning-the-article-left-ventricular-non-compaction-associated-with-hypertrophic%C3%A2
#2
https://www.readbyqxmd.com/read/28703265/noncompaction-may-not-only-be-non-isolated-but-also-myopathic-commentary-to-the-article-left-ventricular-non-compaction-associated-with-hypertrophic-cardiomyopathy-in-the-same-patient
#3
https://www.readbyqxmd.com/read/28691389/fetal-left-ventricular-non-compaction-cardiomyopathy-with-ascites-a-case-report
#4
Junsuke Muraoka, Yuki Kodama, Hiroshi Sameshima, Kaori Michikata, Satoshi Matsuzawa, Oohashi Masanao, Masatoki Kaneko, Mayumi Akaki, Yuichiro Sato
Here we report a case of fetal left ventricular non-compaction cardiomyopathy with ascites and cardiac dysfunction at a gestational age of 34(+5)  weeks. Laboratory tests did not reveal any sign of viral infection in utero. A female neonate weighing 2436 g was delivered by emergency cesarean section due to non-reassuring fetal status. Postnatal echocardiography confirmed left ventricular non-compaction cardiomyopathy with severe cardiac failure. Although she was treated effectively during the acute period by continuous flow peritoneal dialysis, surgical ligation of a patent ductus arteriosus, and inhaled nitric oxide, she died on day 41 of life...
July 10, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28687944/prolonged-qtc-indicates-the-clinical-severity-and-poor-prognosis-in-patients-with-isolated-left-ventricular-non-compaction
#5
Hongmei Zhou, Xue Lin, Ligang Fang, Wenlin Zhu, Xihai Zhao, Haiyan Ding, Meng Jiang, Heng Ge, Quan Fang, Ben He
Isolated left ventricular non-compaction (LVNC) is a rare cardiomyopathy that leads to severe clinical complications. This study is to investigate whether or not prolonged QTc is a good indicator for evaluating the severity of fibrosis and predicting the prognosis of LVNC, and if native T1 can be used to quantify the fibrosis. 32 LVNC patients and 14 healthy controls with matched age and sex were examined by CMR and ECG to acquire native T1, QTc interval, and ECG abnormalities. 18 LVNC patients had normal QTc and 14 LVNC patients had prolonged QTc...
July 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28645170/non-compaction-cardiomyopathy-and-incessant-supraventricular-tachycardia-an-unusual-first-presentation
#6
Cosima Jahnke, Ingo Paetsch, Gerhard Hindricks, Sergio Richter
No abstract text is available yet for this article.
June 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28608878/structural-evolution-and-dielectric-properties-of-suspensions-of-carbon-nanotubes-in-nematic-liquid-crystals
#7
S Tomylko, O Yaroshchuk, O Koval'chuk, N Lebovka
Structuring of carbon nanotubes (CNTs) in liquid crystals (LCs) and electro-physical characteristics of LC + CNT suspensions were studied in a very broad range of CNT concentrations, C, from 10(-5) wt% (highly diluted suspensions) to 2.5 wt% (highly viscous suspensions). Along with the conventional sandwich cells with the transparent electrodes on the substrates, we used the cells with the in-plane applied electrical field in order to monitor changes of electrical parameters in the same direction as the structural changes observed under an optical microscope...
June 28, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28605653/left-ventricle-remodeling-in-patients-with-%C3%AE-thalassemia-major-an-emerging-differential-diagnosis-with-left-ventricle-noncompaction-disease
#8
Elisabetta Chiodi, Marianna Nardozza, Maria Rita Gamberini, Alessia Pepe, Massimo Lombardi, Giorgio Benea, Donato Mele
To differentiate left ventricle non-compaction (LVNC) from hypertrabeculated myocardium due to LV remodeling in β-thalassemia major (β-TM) patients, cardiac magnetic resonance (CMR) images of 38 β-TM patients and 10 LVNC patients were compared using 3 diagnostic criteria: ratio of diastolic segmental non-compacted to compacted myocardium (NC/C ratio) >2.5, percentage of non-compacted LV mass (NC-LVM%) >20% and >25% of global LV mass. Specificity of NC/C ratio of >2.5 was the lowest (58%) and of NC-LVM% of >25% the highest (93%)...
May 17, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28594399/essential-but-partially-redundant-roles-for-pou4f1-brn-3a-and-pou4f2-brn-3b-transcription-factors-in-the-developing-heart
#9
Lauren J Maskell, Kashif Qamar, Aram A Babakr, Thomas A Hawkins, Richard J Heads, Vishwanie S Budhram-Mahadeo
Congenital heart defects contribute to embryonic or neonatal lethality but due to the complexity of cardiac development, the molecular changes associated with such defects are not fully understood. Here, we report that transcription factors (TFs) Brn-3a (POU4F1) and Brn-3b (POU4F2) are important for normal cardiac development. Brn-3a directly represses Brn-3b promoter in cardiomyocytes and consequently Brn-3a knockout (KO) mutant hearts express increased Brn-3b mRNA during mid-gestation, which is linked to hyperplastic growth associated with elevated cyclin D1, a known Brn-3b target gene...
June 8, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28567093/cardiomyopathies-with-mixed-and-inapparent-morphological-features-in-cardiac-troponin-i3-mutation
#10
Dae-Won Sohn, Hyung-Kwan Kim, Yong-Jin Kim, Seil Oh, Moon-Woo Seong, Sung-Sup Park
The fact that different types of cardiomyopathies can be manifested by the same sarcomere protein gene mutation in a single family is well known. However, mixed features of different types of cardiomyopathies in a single patient have not been well appreciated. We identified a novel mutation in cardiac troponin I3 (Arg186Gly) in the present case, and two of the family members showed mixed morphologic features of hypertrophic cardiomyopathy and left ventricular non-compaction. Moreover, both the features of cardiomyopathies were not apparent for each type of cardiomyopathy...
May 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28510647/epicardial-cardioverter-defibrillator-implantation-in-a-4-month-old-infant-bridged-to-heart-transplantation
#11
Cristina Carro, Alberto Francesco Cereda, Giuseppe Annoni, Stefano Maria Marianeschi
Implantable cardioverter-defibrillator (ICD) is the gold standard therapy for the prevention of sudden cardiac death. Nevertheless, ICD placement in the paediatric population is still limited because of several technical difficulties. Several implantation techniques have been proposed but experience in infants with very low weight and less than 6 months is very limited. We herein describe a case of a minimally invasive ICD epicardial implantation in a 4-month-old infant weighing 5 kg. A diagnosis of arrhythmic cardiomyopathy with left ventricular non-compaction disease with ventricular tachycardia storms, QT prolongation and Wolff-Parkinson-White pattern was made...
May 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28510120/obscurin-variants-and-inherited-cardiomyopathies
#12
REVIEW
Steven Marston
The inherited cardiomyopathies, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and left ventricular non-compaction (LVNC), have been frequently associated with mutations in sarcomeric proteins. In recent years, advances in DNA sequencing technology has allowed the study of the giant proteins of the sarcomere, such as titin and nebulin. Obscurin has been somewhat neglected in these studies, largely because its functional role is far from clear, although there was an isolated report in 2007 of obscurin mutations associated with HCM...
June 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28503382/poly-adp-ribosylation-is-present-in-murine-sciatic-nerve-fibers-and-is-altered-in-a-charcot-marie-tooth-1e-neurodegenerative-model
#13
Laura I Lafon Hughes, Carlos J Romeo Cardeillac, Karina B Cal Castillo, Salomé C Vilchez Larrea, José R Sotelo Sosa, Gustavo A Folle Ungo, Silvia H Fernández Villamil, Alejandra E Kun González
BACKGROUND: Poly-ADP-ribose (PAR) is a polymer synthesized by poly-ADP-ribose polymerases (PARPs) as a postranslational protein modification and catabolized mainly by poly-ADP-ribose glycohydrolase (PARG). In spite of the existence of cytoplasmic PARPs and PARG, research has been focused on nuclear PARPs and PAR, demonstrating roles in the maintenance of chromatin architecture and the participation in DNA damage responses and transcriptional regulation. We have recently detected non-nuclear PAR structurally and functionally associated to the E-cadherin rich zonula adherens and the actin cytoskeleton of VERO epithelial cells...
2017: PeerJ
https://www.readbyqxmd.com/read/28458700/echocardiographic-characteristics-of-isolated-left-ventricular-noncompaction
#14
Afsoon Fazlinezhad, Mohammad Vojdanparast, Shadi Sarafan, Pouya Nezafati
BACKGROUND: Although isolated left ventricular noncompaction (ILVNC) has been described almost two decades ago, our knowledge about its diagnosis, presentation, echocardiographic features and clinical outcome is sparse. We aimed to assess the echocardiographic and clinical characteristics of ILVNC in a group of patients referred to our center. METHODS: Patients who were referred to a tertiary referral center, affiliated with Mashhad University of Medical Sciences, with primary diagnosis of dilated cardiomyopathy underwent comprehensive echocardiographic evaluation...
September 2016: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/28421585/left-ventricular-non-compaction-associated-with-hypertrophic-cardiomyopathy-in-the-same-patient
#15
Lobna Laaroussi, Afef Ben Halima, Marouane Boukhris, Faouzi Addad, Salem Kachboura
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28381694/aortopathy-in-an-adult-with-tricuspid-atresia-and-left-ventricular-non-compaction-after-fontan-procedure
#16
Tomotaka Murakami, Yoshiki Mori, Nao Inoue, Sachie Kaneko, Yasumi Nakashima
No abstract text is available yet for this article.
April 5, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28379356/decreased-glycolytic-metabolism-in-non-compaction-cardiomyopathy-by-18f-fluoro-2-deoxyglucose-positron-emission-tomography-new-insights-into-pathophysiological-mechanisms-and-clinical-implications
#17
Marcelo Dantas Tavares de Melo, Maria Clementina Pinto Giorgi, Antonildes Nascimento Assuncao, Roberto Nery Dantas, Jose de Arimateia Araujo Filho, Jose Rodrigues Parga Filho, Ana Luiza de Souza Bierrenbach, Camila Rocon de Lima, José Soares, José Claudio Meneguetti, Charles Mady, Ludhmila Abrahão Hajjar, Roberto Kalil Filho, Edimar Alcides Bocchi, Vera Maria Cury Salemi
Aims: The pathophysiological mechanisms of left ventricular non-compaction cardiomyopathy (LVNC) remain controversial. This study performed combined 18F-fluoro-2-deoxyglucose dynamic positron emission tomography (FDG-PET) and 99mTc-sestamibi single-photon emission computed tomography (SPECT) studies to evaluate myocardial glucose metabolism and perfusion in patients with LVNC and their clinical implications. Methods and results: Thirty patients (41 ± 12 years, 53% male) with LVNC, diagnosed by cardiovascular magnetic resonance (CMR) criteria, and eight age-matched healthy controls (42 ± 12 years, 50% male) were prospectively recruited to undergo FDG-PET with measurement of the myocardial glucose uptake rate (MGU) and SPECT to investigate perfusion-metabolism patterns...
March 30, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28369760/clinical-genetic-testing-in-pediatric-cardiomyopathy-is-bigger-better
#18
Allison Chang Ouellette, Jacob Mathew, Ashok Kumar Manickaraj, George Manase, Laura Zahavich, Judith Wilson, Kristen George, Lee Benson, Sarah Bowdin, Seema Mital
For clinical genetic testing of cardiomyopathy (CMP), current guidelines do not address which gene panels to use: targeted panels specific to a CMP phenotype or expanded (panCMP) panels that include genes associated with multiple phenotypic subtypes. Our objective was to assess the clinical utility of targeted versus panCMP panel testing in pediatric CMPs. 151 pediatric patients with primary hypertrophic (n = 66), dilated (n = 64), restrictive (n = 8), or left-ventricular non-compaction (n = 13) CMP who underwent clinical genetic panel testing at a single centre were included...
March 30, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28343948/left-ventricular-non-compaction-a-cardiomyopathy-with-acceptable-prognosis-in-children
#19
Tao Tian, Yankun Yang, Lanlan Zhou, Fang Luo, Yuehua Li, Peng Fan, Xueqi Dong, Yaxin Liu, Jingang Cui, Xianliang Zhou
BACKGROUND: Data on children with left ventricular non-compaction (LVNC) is sparse. The purpose of this study was to evaluate its clinical profiles in a population of Chinese children. METHODS: From January 2010 to March 2016, consecutive Chinese children (aged <18 years) with LVNC diagnosed by cardiovascular magnetic resonance (CMR) were prospectively recruited at Fuwai Hospital. RESULTS: A total of 41 Chinese children (male: 28%; mean age: 14±4years) were included in this study...
March 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28338096/identification-of-cardiac-hemo-vascular-precursors-and-their-requirement-of-sphingosine-1-phosphate-receptor-1-for-heart-development
#20
Yan Hu, Brian C Belyea, Minghong Li, Joachim R Göthert, R Ariel Gomez, Maria Luisa S Sequeira-Lopez
The cardiac endothelium plays a crucial role in the development of a functional heart. However, the precise identification of the endocardial precursors and the mechanisms they require for their role in heart morphogenesis are not well understood. Using in vivo and in vitro cell fate tracing concomitant with specific cell ablation and embryonic heart transplantation studies, we identified a unique set of precursors which possess hemogenic functions and express the stem cell leukemia (SCL) gene driven by its 5' enhancer...
March 24, 2017: Scientific Reports
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