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https://www.readbyqxmd.com/read/29665457/three-dimensional-geometrical-and-topological-characteristics-of-grains-in-conventional-and-grain-boundary-engineered-316l-stainless-steel
#1
Tingguang Liu, Shuang Xia, Bangxin Zhou, Qin Bai, Gregory S Rohrer
The three-dimensional microstructures of a conventional 316L stainless steel and the same material after grain boundary (GB) engineering have been measured by serial sectioning coupled with electron backscatter diffraction mapping. While it is well known that GB engineered materials are differentiated from conventional materials because of the proportion of coincidence site lattice boundaries, the size of their twin-related domains, and their reduced random boundary connectivity, this work provides a quantitative comparison of the geometrical and topological characteristics of grains in 316L stainless steel before and after GB engineering...
April 10, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29594501/mechanisms-of-trabecular-formation-and-specification-during-cardiogenesis
#2
Mingfu Wu
Trabecular morphogenesis is a key morphologic event during cardiogenesis and contributes to the formation of a competent ventricular wall. Lack of trabeculation results in embryonic lethality. The trabecular morphogenesis is a multistep process that includes, but is not limited to, trabecular initiation, proliferation/growth, specification, and compaction. Although a number of signaling molecules have been implicated in regulating trabeculation, the cellular processes underlying mammalian trabecular formation are not fully understood...
March 28, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29536133/zinc-and-zinc-transporters-novel-regulators-of-ventricular-myocardial-development
#3
Wen Lin, Deqiang Li
Ventricular myocardial development is a well-orchestrated process involving different cardiac structures, multiple signal pathways, and myriad proteins. Dysregulation of this important developmental event can result in cardiomyopathies, such as left ventricle non-compaction, which affect the pediatric population and the adults. Human and mouse studies have shed light upon the etiology of some cardiomyopathy cases and highlighted the contribution of both genetic and environmental factors. However, the regulation of ventricular myocardial development remains incompletely understood...
March 13, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29524076/non-compact-myocardium-assessment-by-cardiac-magnetic-resonance-dependence-on-image-analysis-method
#4
Vincenzo Positano, Antonella Meloni, Francesca Macaione, Maria Filomena Santarelli, Laura Pistoia, Andrea Barison, Salvatore Novo, Alessia Pepe
To compare image analysis methods for the assessment of left ventricle non-compaction from cardiac magnetic resonance (CMR) imaging. CMR images were analyzed in 20 patients and 10 normal subjects. A reference model of the MR signal was introduced and validated based on image data. Non-compact (NC) myocardium size and distribution were assessed by tracing a single, continuous contour delimiting trabeculated region (Jacquier) or by one-by-one selection of trabeculae (Grothoff). The global non-compact/compact (NC/C) ratio, the NC mass, and the segmental NC/C ratio were assessed...
March 9, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29520883/the-nucleotide-bound-substrate-bound-conformation-of-the-mycoplasma-genitalium-dnak-chaperone
#5
Maria Adell, Bárbara M Calisto, Ignacio Fita, Luca Martinelli
Hsp70 chaperones keep protein homeostasis facilitating the response of organisms to changes in external and internal conditions. Hsp70s have two domains - Nucleotide Binding Domain (NBD) and Substrate Binding Domain (SBD) - connected by a conserved hydrophobic linker. Functioning of Hsp70s depend on tightly regulated cycles of ATP hydrolysis allosterically coupled, often together with co-chaperones, to the binding/release of peptide substrates. Here we describe the crystal structure of the Mycoplasma genitalium DnaK (MgDnaK) protein, an Hsp70 homolog, in the non-compact, nucleotide-bound/substrate-bound conformation...
March 9, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29518212/myocardial-t1-mapping-and-extracellular-volume-quantification-in-patients-with-left-ventricular-non-compaction-cardiomyopathy
#6
José A B Araujo-Filho, Antonildes N Assuncao, Marcelo D Tavares de Melo, Loïc Bière, Camila R Lima, Roberto N Dantas, Cesar H Nomura, Vera M C Salemi, Michael Jerosch-Herold, Jose R Parga
Aims: From pathophysiological mechanisms to risk stratification and management, much debate and discussion persist regarding left ventricular non-compaction cardiomyopathy (LVNC). This study aimed to characterize myocardial T1 mapping and extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR), and investigate how these biomarkers relate to left ventricular ejection fraction (LVEF) and ventricular arrhythmias (VA) in LVNC. Methods and results: Patients with LVNC (n = 36) and healthy controls (n = 18) were enrolled to perform a CMR with T1 mapping...
March 6, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29514799/long-term-outcomes-of-childhood-left-ventricular-non-compaction-cardiomyopathy-results-from-a-national-population-based-study
#7
William Y Shi, Margarita Moreno-Betancur, Alan W Nugent, Michael Cheung, Steven Colan, Christian Turner, Gary F Sholler, Terry Robertson, Robert Justo, Andrew Bullock, Ingrid King, Andrew M Davis, Piers E F Daubeney, Robert G Weintraub
Background -Long-term outcomes for childhood left ventricular non-compaction (LVNC) are uncertain. We examined late outcomes for children with LVNC enrolled in a national population-based study. Methods -The National Australian Childhood Cardiomyopathy Study includes all children in Australia with primary cardiomyopathy diagnosed <10 years of age between 1987 and 1996. Outcomes for LVNC subjects with a dilated phenotype (LVNC-D) were compared to those with dilated cardiomyopathy (DCM). Propensity-score analysis was used for risk factor adjustment...
March 7, 2018: Circulation
https://www.readbyqxmd.com/read/29505798/in-silico-study-of-toxicokinetics-and-disease-association-of-chemicals-present-in-smokeless-tobacco-products
#8
Deeksha Bhartiya, Amit Kumar, Jasmine Kaur, Suchitra Kumari, Amitesh Kumar Sharma, Dhirendra N Sinha, Harpreet Singh, Ravi Mehrotra
Smokeless tobacco (SLT) products are consumed by millions of people in over 130 countries around the world. Consumption of SLT has been estimated to cause a number of diseases accounting to more than 0.65 million deaths per year. There is sufficient epidemiological evidence on the association of SLT products with nicotine addiction, cancers of oral cavity and digestive systems but there is a lack of understanding of the role of toxic chemicals in these diseases. We provide the first comprehensive in-silico analysis of chemical compounds present in different SLT products used worldwide...
March 2, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29462293/intrathecal-gene-therapy-in-mouse-models-expressing-cmt1x-mutations
#9
A Kagiava, C Karaiskos, J Richter, C Tryfonos, G Lapathitis, I Sargiannidou, C Christodoulou, K A Kleopa
GJB1 gene mutations affecting the gap junction protein connexin32 (Cx32) cause the X-linked Charcot-Marie-Tooth disease (CMT1X), a common inherited neuropathy. Targeted expression of virally delivered Cx32 in Schwann cells following intrathecal injection of lentiviral vectors in the Cx32 knockout (KO) mouse model of the disease has led to morphological and functional improvement. To examine whether this approach could be effective in CMT1X patients expressing different Cx32 mutants, we treated transgenic Cx32 KO mice expressing the T55I, R75W or N175D CMT1X mutations...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29371594/endothelial-deletion-of-ino80-disrupts-coronary-angiogenesis-and-causes-congenital-heart-disease
#10
Siyeon Rhee, Jae I Chung, Devin A King, Gaetano D'amato, David T Paik, Anna Duan, Andrew Chang, Danielle Nagelberg, Bikram Sharma, Youngtae Jeong, Maximilian Diehn, Joseph C Wu, Ashby J Morrison, Kristy Red-Horse
During development, the formation of a mature, well-functioning heart requires transformation of the ventricular wall from a loose trabecular network into a dense compact myocardium at mid-gestation. Failure to compact is associated in humans with congenital diseases such as left ventricular non-compaction (LVNC). The mechanisms regulating myocardial compaction are however still poorly understood. Here, we show that deletion of the Ino80 chromatin remodeler in vascular endothelial cells prevents ventricular compaction in the developing mouse heart...
January 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29369185/daily-10%C3%A2-mg-rivaroxaban-as-a-therapy-for-ventricular-thrombus-related-to-left-ventricular-non-compaction-cardiomyopathy-a-case-report
#11
Huan Sun, Qini Zhao, Yanjing Wang, Robert Lakin, Haiyan Feng, Xingyu Fan, Huiling Luo, Dongmei Gao, Lin Liu, Yuquan He, Ping Yang
RATIONALE: Left ventricular non-compaction cardiomyopathy (LVNC) is a rare heart disorder related to thrombosis. Anticoagulant therapy is suggested for the treatment of this disease. The success of the novel oral anticoagulant rivaroxaban as a treatment option for this disorder is unclear. PATIENT CONCERNS: A 43-year-old man who felt dizzy at rest was found to have an intraventricular thrombus. DIAGNOSES: The thrombus was confirmed by echocardiography...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29315582/a-dual-role-for-integrin-%C3%AE-6%C3%AE-4-in-modulating-hereditary-neuropathy-with-liability-to-pressure-palsies
#12
Yannick Poitelon, Vittoria Matafora, Nicholas Silvestri, Desirée Zambroni, Claire McGarry, Nora Serghany, Thomas Rush, Domenica Vizzuso, Felipe A Court, Angela Bachi, Lawrence Wrabetz, Maria Laura Feltri
Peripheral myelin protein 22 (PMP22) is a component of compact myelin in the peripheral nervous system. The amount of PMP22 in myelin is tightly regulated, and PMP22 over or under-expression cause Charcot-Marie-Tooth 1A (CMT1A) and Hereditary Neuropathy with Pressure Palsies (HNPP). Despite the importance of PMP22, its function remains largely unknown. It was reported that PMP22 interacts with the β4 subunit of the laminin receptor α6β4 integrin, suggesting that α6β4 integrin and laminins may contribute to the pathogenesis of CMT1A or HNPP...
January 8, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29305187/cardiac-arrest-and-ventricular-arrhythmia-in-adults-with-ebstein-anomaly-and-left-ventricular-non-compaction
#13
Magdalena Kumor, Magdalena Lipczyńska, Elzbieta Katarzyna Biernacka, Anna Klisiewicz, Anna Wójcik, Marek Konka, Katarzyna Kożuch, Piotr Szymański, Piotr Hoffman
BACKGROUND: Ebstein anomaly is a complex, congenital heart defect that is associated with a variety of cardiac abnormalities. Studies found a similar sarcomere gene mutation in patients with Ebstein anomaly (EA) and patients with isolated left ventricular non-compaction (LVNC). AIM: We aimed to show the prevalence of LVNC and its potential relationship with severe cardiac events (VT - ventricular tachycardia, cardiac arrest) in adult patients with EA. METHODS: We conducted a retrospective search of our institutional database from 2010 to 2014 for patients with EA and reviewed patients' medical records (age, sex, clinical presentation, electrocardiographic, echocardiographic, and CMR - cardiac magnetic resonance features)...
May 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29241460/fractal-analysis-of-left-ventricular-trabeculations-is-associated-with-impaired-myocardial-deformation-in-healthy-chinese
#14
Jiashen Cai, Jennifer Ann Bryant, Thu-Thao Le, Boyang Su, Antonio de Marvao, Declan P O'Regan, Stuart A Cook, Calvin Woon-Loong Chin
BACKGROUND: Left ventricular (LV) non-compaction (LVNC) is defined by extreme LV trabeculation, but is measured variably. Here we examined the relationship between quantitative measurement in LV trabeculation and myocardial deformation in health and disease and determined the clinical utility of semi-automated assessment of LV trabeculations. METHODS: Cardiovascular magnetic resonance (CMR) was performed in 180 healthy Singaporean Chinese (age 20-69 years; males, n = 91), using balanced steady state free precession cine imaging at 3T...
December 14, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29224255/the-highest-mortality-rates-in-childhood-dilated-cardiomyopathy-occur-during-the-first-year-after-diagnosis
#15
Shalan Fadl, Håkan Wåhlander, Katja Fall, Yang Cao, Jan Sunnegårdh
AIM: The aim of the study was to assess the incidence, mortality and morbidity of dilated cardiomyopathy (DCM) and noncompaction of the left ventricle (LVNC) in Swedish children. METHODS: We reviewed hospital records of all children with dilated cardiomyopathy (DCM) or left ventricular noncompaction cardiomyopathy (LVNC) up to the age of 18 in the healthcare region of western Sweden from 1991 to 2015. RESULTS: In total, 69 cases (61% males) were identified...
April 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29214778/supplementary-diagnostic-landmarks-of-left-ventricular-non-compaction-on-magnetic-resonance-imaging
#16
Marko Boban, Vladimir Pesa, Natko Beck, Sime Manola, Marinko Zulj, Ante Rotim, Aleksandar Vcev
PURPOSE: Diagnostic criteria for left ventricular non-compaction (LVNC) are still a matter of dispute. The aim of our present study was to test the diagnostic value of two novel diagnostic cardiac magnetic resonance (CMR) parameters: proof of non-compact (NC) myocardium blood flow using T2 sequences and changes in geometry of the left ventricle. MATERIALS AND METHODS: The study included cases with LVNC and controls, from a data base formed in a period of 3.5 years (n=1890 exams), in which CMR protocol included T2 sequences...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29207943/auxiliary-diagnostic-potential-of-ventricle-geometry-and-late-gadolinium-enhancement-in-left-ventricular-non-compaction-non-randomized-case-control-study
#17
Marko Boban, Vladimir Pesa, Ivo Darko Gabric, Sime Manola, Viktor Persic, Helena Antic-Kauzlaric, Marinko Zulj, Aleksandar Vcev
BACKGROUND: There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls. METHODS: Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital's database (3.75 years; n=1975 exams). Matching sample of controls included cases with no structural heart disease, hypertrophic or dilative cardiomyopathy, arrhythmogenic right ventricular dysplasia or subacute myocarditis...
December 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29203757/variant-of-myocardial-infarction-course-in-the-patient-with-left-ventricular-non-compaction
#18
Natalia Y Osovska, Oleksandr I Datsyuk, Natalia V Kuzminova, Yevhen V Shaprynskyi, Hennadii V Bevz, Yaroslav M Pashynskyy, Oleksandr D Bondarchuk, Olena V Sergiichuk, Yaroslav V Karyi, Galina M Mazur
Non-compacted left ventricle in adults is a rare occurrence, though it is diagnosed even more rarely. As a rule in patients with non-compacted left ventricle (LVNC) other pathologic condition is diagnosed, notably hypertrophic or dilated cardiomyopathy. The majority of LVNC cases are diagnosed in early infancy but currently there are asymptomatic cases detected by means of echocardiographic examination. Real prevalence of LVNC is unknown. According to many authors LVNC occurs in 9.2-9.5% of children with diagnosed cardiomyopathies...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29188317/genetic-testing-in-pediatric-cardiomyopathy
#19
Chalani D Ellepola, Linda M Knight, Peter Fischbach, Shriprasad R Deshpande
Genetic testing is recommended in patients with dilated cardiomyopathy (DCM); however, limited studies demonstrate high yields of genetic testing in non-hypertrophic (HCM) patients. Furthermore, there is sparse genotype-phenotype data in pediatric DCM patients. We performed a retrospective review of 70 consecutive probands with cardiomyopathy (non-HCM) who underwent genetic evaluation. Mean age at presentation was 5.48 years. Echocardiography revealed mean ejection fraction of 32.4%. The LVEDd z score ranged from - 5...
March 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29173988/non-compaction-cardiomyopathy-a-short-review-of-a-controversial-entity
#20
REVIEW
Rebeca Lorca, José Rozado, María Martín
Non-compaction cardiomyopathy is a heterogeneous and complex entity concerning which there are still many doubts to be resolved. While the American Heart Association includes it among genetic cardiomyopathies, the European Society of Cardiology treats it as an unclassified cardiomyopathy. It may present in a sporadic or familial form, isolated or associated with other heart diseases, affecting only the left ventricle or both and can sometimes appear as a mixed phenotype in patients with other cardiomyopathies...
November 22, 2017: Medicina Clínica
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