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https://www.readbyqxmd.com/read/28535480/ozonation-of-the-oxybenzone-octinoxate-and-octocrylene-uv-filters-reaction-kinetics-absorbance-characteristics-and-transformation-products
#1
Zachary R Hopkins, Sebastian Snowberger, Lee Blaney
UV-filters (UVFs) are active ingredients in personal care products that protect skin from exposure to UV light. Environmentally-relevant concentrations of UVFs have recently been linked to toxicity in aquatic organisms, necessitating research into improved UVF removal in water/wastewater treatment. Here, we investigated ozonation of the three most commonly employed UVFs: octinoxate (OMC), octocrylene (OC), and oxybenzone (OXY). Specific second-order rate constants for UVF reaction with ozone were identified as follows: OMC, 5...
May 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28535254/invited-commentary-cassel-s-the-contribution-of-the-social-environment-to-host-resistance-a-modern-classic
#2
Sherman A James
John Cassel's 1976 paper "The Contribution of the Social Environment to Host Resistance" (Am J Epidemiol. 1976;104(2):107-123) is widely regarded as a classic in epidemiology. He makes the compelling argument that the quality of a person's social relationships, that is, the degree to which her relationships are more stressful than supportive (or vice versa) influences her susceptibility to disease independent of genetic endowment, diet, physical activity, etc. Cassel's provocative thesis was anchored in a cogent synthesis of findings from animal experiments and observational studies on diverse human populations...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535206/clinical-exome-sequencing-reports-current-informatics-practice-and-future-opportunities
#3
Rajeswari Swaminathan, Yungui Huang, Caroline Astbury, Sara Fitzgerald-Butt, Katherine Miller, Justin Cole, Christopher Bartlett, Simon Lin
The increased adoption of clinical whole exome sequencing (WES) has improved the diagnostic yield for patients with complex genetic conditions. However, the informatics practice for handling information contained in whole exome reports is still in its infancy, as evidenced by the lack of a common vocabulary within clinical sequencing reports generated across genetic laboratories. Genetic testing results are mostly transmitted using portable document format, which can make secondary analysis and data extraction challenging...
May 23, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28534535/the-potential-of-organoids-in-urological-cancer-research
#4
REVIEW
Shangqian Wang, Dong Gao, Yu Chen
Technical advances in the development of organoid systems enable cell lines, primary adult cells, or stem or progenitor cells to develop into diverse, multicellular entities, which can self-renew, self-organize, and differentiate. These 3D organoid cultures have proven to be of value in increasing our understanding of the biology of disease and offer the potential of regenerative and genetic therapies. The successful application of 3D organoids derived from adult tissue into urological cancer research can further our understanding of these diseases and could also provide preclinical cancer models to realize the precision medicine paradigm by therapeutic screening of individual patient samples ex vivo...
May 23, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28534270/occurrence-distribution-and-attenuation-of-pharmaceuticals-and-personal-care-products-in-the-riverside-groundwater-of-the-beiyun-river-of-beijing-china
#5
Lei Yang, Jiang-Tao He, Si-Hui Su, Ya-Feng Cui, De-Liang Huang, Guang-Cai Wang
This study investigated the occurrence, seasonal-spatial distribution characteristics, and attenuation process of 15 pharmaceuticals and personal care products (PPCPs) in riverside sections of Beiyun River of Beijing. The overall PPCP levels both in surface water and riverside groundwater were moderate on the global scale, and showed higher concentrations in the dry season mainly caused by water temperature variation. Caffeine (CF), carbamazepine (CBZ), metoprolol (MTP), N,N-diethyl-meta-toluamide (DEET), diclofenac (DF), bezafibrate (BF), and gemfibrozil (GF) were seven representative PPCPs, because the rest eight studied compounds occurred in low concentrations and less than 15% of the total concentration of PPCPs...
May 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28534063/-the-new-law-on-radiation-protection-as-a-consequence-of-the-eu-safety-standard-of-2013
#6
REVIEW
G Layer
The transformation of a European guideline (2013/59/Euratom) from 2013 into national law requires adaptation of the national statutory regulations. This year, all areas of protection from ionizing radiation will be subject to the new radiation protection law (StrlSchG). Through this, the German X‑ray and Radiation Protection Acts will be combined to form a higher level of authority. The main parts of the StrlSchG will receive a new classification and will be organized according to the exposure scenario: radiation protection in planned exposure scenarios, radiation protection in emergency exposure scenarios, radiation protection in existing exposure scenarios, and the regulation of overall exposure scenarios...
May 22, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28532995/histological-subtypes-of-hepatocellular-carcinoma-are-related-to-gene-mutations-and-molecular-tumour-classification
#7
Julien Calderaro, Gabrielle Couchy, Sandrine Imbeaud, Giuliana Amaddeo, Eric Letouzé, Jean-Frédéric Blanc, Christophe Laurent, Yacine Hajji, Daniel Azoulay, Paulette Bioulac-Sage, Jean-Charles Nault, Jessica Zucman-Rossi
BACKGROUND AND AIMS: Our increasing understanding of hepatocellular carcinoma (HCC) biology holds promise for personalized care, however its translation into clinical practice requires a precise knowledge of its relationship to tumour phenotype. METHODS: We aimed at investigating molecular-phenotypic correlations in a large series of HCC. To this purpose, 343 surgically resected HCC were investigated by pathological review, immunohistochemistry, gene expression profiling and sequencing...
May 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28532432/periodontitis-and-early-mortality-among-adults-treated-with-hemodialysis-a-multinational-propensity-matched-cohort-study
#8
Marinella Ruospo, Suetonia C Palmer, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok, Paul Stroumza, Anna Bednarek-Skublewska, Jan Dulawa, Luc Frantzen, Domingo Del Castillo, Staffan Schon, Amparo G Bernat, Jorgen Hegbrant, Charlotta Wollheim, Letizia Gargano, Casper P Bots, Giovanni Fm Strippoli
BACKGROUND: Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney failure. METHODS: ORAL-D was a propensity matched analysis in 3338 dentate adults with end-stage kidney disease treated in a hemodialysis network in Europe and South America designed to examine the association between periodontitis and all-cause and cardiovascular-related mortality in people on long-term hemodialysis...
May 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28532304/producing-hiv-estimates-from-global-advocacy-to-country-planning-and-impact-measurement
#9
Mary Mahy, Tim Brown, John Stover, Neff Walker, Karen Stanecki, Wilford Kirungi, Txema Garcia-Calleja, Peter D Ghys
BACKGROUND: The development of global HIV estimates has been critical for understanding, advocating for and funding the HIV response. The process of generating HIV estimates has been cited as the gold standard for public health estimates. OBJECTIVE: This paper provides important lessons from an international scientific collaboration and provides a useful model for those producing public health estimates in other fields. DESIGN: Through the compilation and review of published journal articles, United Nations reports, other documents and personal experience we compiled historical information about the estimates and identified potential lessons for other public health estimation efforts...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28530510/self-reported-physical-activity-and-exercise-patterns-in-children-with-sickle-cell-disease
#10
Osarhiemen A Omwanghe, Devin S Muntz, Soyang Kwon, Simone Montgomery, Opeyemi Kemiki, Lewis L Hsu, Alexis A Thompson, Robert I Liem
PURPOSE: Sickle cell disease (SCD) significantly affects physical functioning. We examined physical activity (PA) patterns in children with SCD versus a national sample and factors associated with PA and participation in physical education and organized sports. METHOD: One hundred children with SCD completed a 58-item survey with questions from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) Physical Activity Questionnaire and others on physical education and sports, disease impact, and physical functioning...
May 22, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28530312/-the-second-victim-treating-the-health-care-providers
#11
REVIEW
Shimrit Shor, Orna Tal, Ron Maymon
During their professional careers, physicians and other health care providers are repeatedly exposed to emotional stress. This is usually secondary to coping with the results of a medical error or complicated medical event. Generally, in the above cases, the patient and his/her family are in the center of the medical system, being "the first victim" of such an event, while the involved caregiver, who provided the medical service, is categorized as the "second victim". "Second victims" may feel anxiety, fear, guilt or anger and experience social withdrawal, which may lead to troubling memories, depression and insomnia...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28530049/examining-the-effects-of-hiv-self-testing-compared-to-standard-hiv-testing-services-a-systematic-review-and-meta-analysis
#12
Cheryl C Johnson, Caitlin Kennedy, Virginia Fonner, Nandi Siegfried, Carmen Figueroa, Shona Dalal, Anita Sands, Rachel Baggaley
INTRODUCTION: HIV self-testing (HIVST) is a discreet and convenient way to reach people with HIV who do not know their status, including many who may not otherwise test. To inform World Health Organization (WHO) guidance, we assessed the effect of HIVST on uptake and frequency of testing, as well as identification of HIV-positive persons, linkage to care, social harm, and risk behaviour. METHODS: We systematically searched for studies comparing HIVST to standard HIV testing until 1 June 2016...
May 15, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28529068/adverse-outcome-pathways-application-to-enhance-mechanistic-understanding-of-neurotoxicity
#13
REVIEW
Anna Bal-Price, M E Meek
Recent developments have prompted the transition of empirically based testing of late stage toxicity in animals for a range of different endpoints including neurotoxicity to more efficient and predictive mechanistically based approaches with greater emphasis on measurable key events early in the progression of disease. The adverse outcome pathway (AOP) has been proposed as a simplified organizational construct to contribute to this transition by linking molecular initiating events and earlier (more predictive) key events at lower levels of biological organization to disease outcomes...
May 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28528598/the-emergence-of-personal-growth-amongst-healthcare-professionals-who-care-for-dying-children
#14
Laura Beaune, Barbara Muskat, Samantha J Anthony
OBJECTIVE: Compassion fatigue, burnout, and vicarious traumatization are prominent topics in the current literature on the impact of the rewarding but challenging work of healthcare professionals who care for patients with life-limiting illnesses. The positive effects of caregiving constitute a newly emerging outcome that has been relatively unexplored in the pediatric literature, and yet they may play an important role in contributing to the satisfaction and well-being of the healthcare professionals who care for children who have a life-limiting illness...
May 22, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28528311/rapid-screening-and-identification-of-chemical-hazards-in-surface-and-drinking-water-using-high-resolution-mass-spectrometry-and-a-case-control-filter
#15
Sarit L Kaserzon, Amy L Heffernan, Kristie Thompson, Jochen F Mueller, Maria Jose Gomez Ramos
Access to clean, safe drinking water poses a serious challenge to regulators, and requires analytical strategies capable of rapid screening and identification of potentially hazardous chemicals, specifically in situations when threats to water quality or security require rapid investigations and potential response. This study describes a fast and efficient chemical hazard screening strategy for characterising trace levels of polar organic contaminants in water matrices, based on liquid chromatography high resolution mass spectrometry with post-acquisition 'case-control' data processing...
May 12, 2017: Chemosphere
https://www.readbyqxmd.com/read/28528023/medication-management-activities-performed-by-informal-caregivers-of-older-adults
#16
Kevin A Look, Jamie A Stone
BACKGROUND: Medication management is commonly performed by informal caregivers, yet they are often unprepared and ill-equipped to manage complex medication regimens for their older adult care recipients. In order to develop interventions that will enhance the caregiver's ability to safely and confidently manage medications, it is critical to first understand caregiver challenges and unmet needs related to medication management. OBJECTIVES: To explore how informal caregivers manage medications for their older adult care recipients by identifying the activities involved in medication management and the tools or strategies used to facilitate these activities...
May 16, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28527476/forensic-medicine-and-the-military-population-international-dental-records-and-personal-identification-concerns
#17
Maria Inês Guimarães, Augusta Silveira, Teresa Sequeira, Joaquim Gonçalves, Maria José Carneiro Sousa, Aurora Valenzuela
INTRODUCTION: The first goal of this research was to perceive the global commitment towards the organization and archiving of dental records and to compare it with each country's security risk rating. The second one was to study dental records in a sample of the Portuguese military population, using the available national dental records. MATERIAL AND METHODS: An e-mail was sent to representative dentistry associations in several countries, requesting some information concerning the professionals' awareness of this issue...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28526977/standards-of-practice-in-interventional-neuroradiology
#18
Olav Jansen, Istvan Szikora, Francesco Causin, Hartmut Brückmann, Kyriakos Lobotesis
The growing importance of INR has resulted in the need to define and promote professional standards of clinical practice. Several professional organizations have published guidelines recently for the neurointerventional treatment of cerebrovascular diseases, including technical and personal recommendations, but detailed definitions of technical and organizational conditions needed for the safe and effective performance of such treatments are lacking. To fill this gap ESNR, ESMINT and the UEMS Division for Neuroradiology established a working group, to develop a consensus paper on "Standards of Practice in Interventional Neuroradiology"...
May 19, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28526674/development-of-a-web-based-health-care-intervention-for-patients-with-heart-disease-lessons-learned-from-a-participatory-design-study
#19
Birgitte Noergaard, Marianne Sandvei, Nina Rottmann, Helle Johannessen, Uffe Wiil, Thomas Schmidt, Susanne S Pedersen
BACKGROUND: The use of telemedicine technologies in health care has increased substantially, together with a growing interest in participatory design methods when developing telemedicine approaches. OBJECTIVE: We present lessons learned from a case study involving patients with heart disease and health care professionals in the development of a personalized Web-based health care intervention. METHODS: We used a participatory design approach inspired by the method for feasibility studies in software development...
May 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28526628/heparin-based-hydrogels-induce-human-renal-tubulogenesis-in-vitro
#20
Heather M Weber, Mikhail V Tsurkan, Valentina Magno, Uwe Freudenberg, Carsten Werner
Dialysis or kidney transplantation is the only therapeutic option for end stage renal disease. Accordingly, there is a large unmet clinical need for new causative therapeutic treatments. Obtaining robust models that mimic the complex nature of the human kidney is a critical step in the development of new therapeutic strategies. Here we establish a synthetic in vitro human renal tubulogenesis model based on a tunable glycosaminoglycan-hydrogel platform. In this system, renal tubulogenesis can be modulated by the adjustment of hydrogel mechanics and degradability, growth factor signaling, and the presence of insoluble adhesion cues, potentially providing new insights for regenerative therapy...
May 16, 2017: Acta Biomaterialia
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