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https://www.readbyqxmd.com/read/27915307/diversity-and-antifungal-drug-susceptibility-of-cryptococcus-isolates-in-thailand
#1
Navaporn Worasilchai, Marut Tangwattanachuleeporn, Kornvalee Meesilpavikkai, Claudia Folba, Mourine Kangogo, Uwe Groß, Michael Weig, Oliver Bader, Ariya Chindamporn
Yeasts of the Cryptococcus species complex are the causative agent of cryptococcosis, especially in human immunodeficiency virus (HIV) positive individuals. Cerebral or disseminated cryptococcosis has a very high mortality rate worldwide, including in Thailand. Additionally, an increasing rate of antifungal drug resistant cryptococcal isolates has been reported in several neighboring countries, complicating therapeutic approaches. To understand the situation of this infection in Thailand, we retrospectively investigated the molecular epidemiology and antifungal drug resistance in a collection of 74 clinical, 52 environmental and two veterinary isolates using the URA5-RFLP for typing and the EUCAST guideline for susceptibility testing...
December 3, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27901310/topical-antimycotics-for-oral-candidiasis-in-warfarin-users
#2
Maja Hellfritzsch, Anton Pottegård, Andreas James Thestrup Pedersen, Alaa Burghle, Fatima Mouaanaki, Jesper Hallas, Erik Lerkevang Grove, Per Damkier
Treatment of oral candidiasis in warfarin users may be complicated by drug-drug interactions between warfarin and topically applied antimycotics. However, current knowledge of these putative drug-drug interactions is merely based on case series. We therefore performed a cohort cross-over study with the objective to evaluate the potential drug-drug interactions between warfarin and miconazole oral gel or nystatin oral solution. The cohort consisted of individuals using warfarin in the period of 1998-2012 (n≈7,400)...
November 30, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27871726/identification-and-determination-of-chlorinated-azoles-in-sludge-using-liquid-chromatography-quadrupole-time-of-flight-and-triple-quadrupole-mass-spectrometry-platforms
#3
G Castro, M Roca, I Rodríguez, M Ramil, R Cela
Four antimycotic drugs (tioconazole, TCZ; sertaconazole, STZ; fenticonazole, FTZ and itraconazole, ITZ) and the fungicide imazalil (IMZ) are determined in sludge from sewage treatment plants (STPs) following a bottom-up analytical strategy. First, sludge extracts, obtained under different sample preparation conditions, were analyzed by liquid chromatography (LC) quadrupole time-of-flight (QTOF) mass spectrometry (MS). A non-target search strategy, combined with the use of the chlorine mass filter, permitted to detect several chlorinated pollutants including the above referred azoles, which either had not been previously reported (TCZ, STZ, FTZ and ITZ), or scarcely investigated (IMZ), in this environmental compartment...
December 9, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27870529/infections-and-exposure-to-anti-infective-agents-and-the-risk-of-severe-mental-disorders-a-nationwide-study
#4
O Köhler, L Petersen, O Mors, P B Mortensen, R H Yolken, C Gasse, M E Benros
OBJECTIVE: Severe infections are associated with increased risks of mental disorders; however, this is the first large-scale study investigating whether infections treated with anti-infective agents in the primary care setting increase the risks of schizophrenia and affective disorders. METHOD: We identified all individuals born in Denmark 1985-2002 (N = 1 015 447) and studied the association between infections treated with anti-infective agents and the subsequent risk of schizophrenia and affective disorders during 1995-2013...
November 21, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27825527/sensing-metabolites-for-the-monitoring-of-tissue-engineered-construct-cellularity-in-perfusion-bioreactors
#5
Aaron D Simmons, Cortes Williams, Antoine Degoix, Vassilios I Sikavitsas
As the field of tissue engineering progresses ever-further toward realizing clinical implementation of tissue-engineered constructs for wound regeneration, perhaps the most significant hurdle remains the establishment of non-destructive means for real-time in vitro assessment. In order to address this barrier, the study presented herein established the viability of the development of correlations between metabolic rates (specifically oxygen uptake, glucose consumption, and lactate production) and the cellularity of tissue-engineered cultures comprised of rat mesenchymal stem cells dynamically seeded on 85% porous nonwoven spunbonded poly(l-lactic acid) fiber mesh scaffolds...
September 30, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27817919/incidence-and-outcomes-of-positive-donor-corneoscleral-rim-fungal-cultures-after-keratoplasty
#6
Jesse M Vislisel, Kenneth M Goins, Michael D Wagoner, Gregory A Schmidt, Benjamin T Aldrich, Jessica M Skeie, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To determine the incidence of positive corneoscleral donor rim fungal cultures after keratoplasty and to report clinical outcomes of grafts with culture-positive donor rims. DESIGN: Retrospective cohort study. PARTICIPANTS: Consecutive donor corneas and keratoplasty recipients at a single tertiary referral center over 20 years. METHODS: Patient charts were reviewed to determine the incidence of positive donor rim fungal cultures and clinical outcomes of all grafts using contaminated tissue...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27817136/management-of-destructive-candida-albicans-spondylodiscitis-of-the-cervical-spine-a-systematic-analysis-of-literature-illustrated-by-an-unusual-case
#7
REVIEW
Josef Stolberg-Stolberg, Dagmar Horn, Steffen Roßlenbroich, Oliver Riesenbeck, Stefanie Kampmeier, Michael Mohr, Michael J Raschke, René Hartensuer
PURPOSE: Candida induced spondylodiscitis of the cervical spine in immunocompetent patients is an extremely rare infectious complication. Since clinical symptoms might be nonspecific, therapeutic latency can lead to permanent spinal cord damage, sepsis and fatal complications. Surgical debridement is strongly recommended but there is no standard antimycotic regime for postsurgical treatment. This paper summarizes available data and demonstrates another successfully treated case. METHODS: The systematic analysis was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines...
November 5, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27784222/endophytic-peptides-a-source-of-therapeutic-agents
#8
Keerthi Kumari Chikkode Narayana, Jamuna Bai Aswathanarayan, Ravishankar Rai Vittal
Endophytic peptides (EPPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared to the conventional antibiotics. The world human population is increasingly facing different types of health issues. For instance, emerging wide array of the drug-resistant pathogens is a health concern. Research on bioactive agents and other natural products of microbes is essential to combat emerging antimicrobial resistance...
October 25, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27778229/production-of-endothelial-progenitor-cells-from-skin-fibroblasts-by-direct-reprogramming-for-clinical-usages
#9
Phuc Van Pham, Ngoc Bich Vu, Thuy Thi-Thanh Dao, Ha Thi-Ngan Le, Lan Thi Phi, Ngoc Kim Phan
Endothelial progenitor cells (EPCs) play an important role in angiogenesis. However, they exist in limited numbers in the human body. This study was aimed to produce EPCs, for autologous transplantation, using direct reprogramming of skin fibroblasts under GMP-compliant conditions. Fibroblasts were collected and cultured from the skin in DMEM/F12 medium supplemented with 5% activated platelet-rich plasma and 1% antibiotic-antimycotic solution. They were then transfected with mRNA ETV2 and incubated in culture medium under hypoxia (5% oxygen) for 14 d...
October 24, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27770606/simultaneous-formulation-of-terbinafine-and-salvia-monoterpenes-into-chitosan-hydrogel-with-testing-biological-activity-of-corresponding-dialysates-against-c-albicans-yeast
#10
Alexandra Kodadová, Zuzana Vitková, Jarmila Oremusová, Petra Herdová, Anton Ťažký, Peter Mikuš
This work was aimed at a progressive formulation of drugs into chitosan hydrogels. It was taken into consideration that a therapeutic effect of the drugs could be enhanced by a combination of natural compounds with chemical (synthetic) drugs. In this work, sage essential oil (SEO) bicyclic monoterpenes with antiflogistic, antiseptic, and antimycotic properties were combined with terbinafine (TB) having a strong antimycotic activity. Detail optimization of the hydrogel-drugs composition (SEO monoterpenes, TB, chitosan, and polysorbate 80 concentrations), based on permeation experiment and UV absorption/GC-MS analysis of permeated species (eucalyptol, camphor, borneol, thujone, TB) in dialysates, was made...
October 22, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27769470/a-validated-1-h-nmr-method-for-quantitative-analysis-of-%C3%AE-bisabolol-in-essential-oils-of-eremanthus-erythropappus
#11
Cristiane I Cerceau, Luiz C A Barbosa, Elson S Alvarenga, Antonio G Ferreira, Sérgio S Thomasi
α-Bisabolol is a natural terpene produced by Eremanthus erythropappus and is widely used in cosmetics and pharmaceuticals due to its anti-inflammatory, antibacterial and antimycotic properties. Due to these applications, a control of composition and authenticity of commercial oils rich in this terpene is required, resulting in a demand for new methodologies for quality control. In this work a rapid and efficient method for quantification of α-bisabolol in the essential oil of E. erythropappus (candeia) using (1)H NMR was developed, validated and compared to gas chromatography (GC) method...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27766140/a-complex-game-of-hide-and-seek-the-search-for-new-antifungals
#12
Huy X Ngo, Sylvie Garneau-Tsodikova, Keith D Green
Fungal infections directly affect millions of people each year. In addition to the invasive fungal infections of humans, the plants and animals that comprise our primary food source are also susceptible to diseases caused by these eukaryotic microbes. The need for antifungals, not only for our medical needs, but also for use in agriculture and livestock causes a high demand for novel antimycotics. Herein, we provide an overview of the most commonly used antifungals in medicine and agriculture. We also present a summary of the recent progress (from 2010-2016) in the discovery/development of new agents against fungal strains of medical/agricultural relevance, as well as information related to their biological activity, their mode(s) of action, and their mechanism(s) of resistance...
July 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/27750101/development-and-characterization-of-the-voriconazole-loaded-lipid-based-nanoparticles
#13
Petra Füredi, Zsófia Edit Pápay, Kristóf Kovács, Borbála Dalmadi Kiss, Krisztina Ludányi, István Antal, Imre Klebovich
The number of topical fungal infections is growing, mostly owing to immunosuppressive therapy. Several topical fungal infections, such as eye mycoses, can be treated by local administration of antimycotic drugs. One major group of the antifungal agents is triazole, such as voriconazole (VCZ), which is used as the first line treatment of aspergillosis. A disadvantage of VCZ is its low water solubility making the drug difficult to administer in a liquid preparation. The lipid-based nanoparticles (LNP) have attracted increasing attention due to their advantageous properties...
October 1, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27743771/anticandidal-synergistic-activity-of-green-tea-catechins-antimycotics-and-copper-sulphate-as-a-mean-of-combinational-drug-therapy-against-candidiasis
#14
J Anand, N Rai
The present investigation aims at evaluating synergistic herbal based composition of purified catechins with fluconazole, amphotericin B and copper sulphate against Candida albicans (MTCC 3017) and Candida glabrata (MTCC 3019). The catechins were isolated from green tea leaves of Assam, Himachal Pradesh and Uttarakhand regions of India. The synergistic activity of combinations against Candida species was assessed following microdilution checkerboard technique and time kill assay. The inhibitory action of most significant combination on treated Candida cells was assessed by scanning electron microscopy...
October 12, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27683101/an-amphotericin-b-derivative-equally-potent-to-amphotericin-b-and-with-increased-safety
#15
Armando Antillón, Alexander H de Vries, Marcel Espinosa-Caballero, José Marcos Falcón-González, David Flores Romero, Javier González-Damián, Fabiola Eloísa Jiménez-Montejo, Angel León-Buitimea, Manuel López-Ortiz, Ricardo Magaña, Siewert J Marrink, Rosmarbel Morales-Nava, Xavier Periole, Jorge Reyes-Esparza, Josué Rodríguez Lozada, Tania Minerva Santiago-Angelino, María Cristina Vargas González, Ignacio Regla, Mauricio Carrillo-Tripp, Mario Fernández-Zertuche, Lourdes Rodríguez-Fragoso, Iván Ortega-Blake
Amphotericin B is the most potent antimycotic known to date. However due to its large collateral toxicity, its use, although long standing, had been limited. Many attempts have been made to produce derivatives with reduced collateral damage. The molecular mechanism of polyene has also been closely studied for this purpose and understanding it would contribute to the development of safe derivatives. Our study examined polyene action, including chemical synthesis, electrophysiology, pharmacology, toxicology and molecular dynamics...
2016: PloS One
https://www.readbyqxmd.com/read/27671284/pyocyanin-as-anti-tyrosinase-and-anti-tinea-corporis-a-novel-treatment-study
#16
REVIEW
Nessma A El-Zawawy, Sameh S Ali
OBJECTIVE: The aim of this study was to evaluate the efficiency of pyocyanin pigment as a novel compound active against tyrosinase with its depigmentation efficiency for combating Trichophyton rubrum which could be a major causative agent of tinea corporis. METHODS: Fifty swabs of fungal tinea corporis infections were collected and identified. Five MDRPA isolates were tested for their levels of pyocyanin production. The purified extracted pyocyanin was characterized by UV spectrum and FT-IR analysis...
November 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27660182/selective-anticancer-activity-of-the-novel-thiobenzanilide-63t-against-human-lung-adenocarcinoma-cells
#17
Malgorzata Kucinska, Hanna Piotrowska-Kempisty, Natalia Lisiak, Mariusz Kaczmarek, Hanna Dams-Kozlowska, Walter H Granig, Martina Höferl, Walter Jäger, Martin Zehl, Marek Murias, Thomas Erker
Previously, it has been reported that molecules built on the benzanilide and thiobenzanilide scaffold are the promising groups of compounds with several biological activities including antifungal, antimycotic, antibacterial, spasmolytic, and anticancer ones. In this study the mechanism of action of one selected thiobenzanilide derivative N,N'-(1,2-phenylene)bis3,4,5-trifluorobenzothioamide (63T) with strongest cytotoxic activity has been investigated for the first time in human lung adenocarcinoma (A549) and normal lung derived fibroblast (CCD39Lu) in a cell culture model...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27590778/-candiduria-what-now-therapy-of-urinary-tract-infections-with-candida
#18
H Hof
BACKGROUND: Yeasts are found in urine specimens relatively often, especially in the elderly and patients under treatment with broad spectrum antibiotics, i. e. especially in intensive care unit (ICU) patients. In some cases, the number of pathogens is very high, i. e. >10(5)/ml. The clinical relevance of detecting Candida in urine is difficult to assess. In the German S3 guidelines it is apodictically stated that an ascending infection of the urinary tract by yeasts does not occur but this may undoubtedly happen in certain instances in patients at risk, for example in the elderly, in diabetic persons and in the case of foreign bodies in the urinary tract...
September 2, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27574791/effect-of-chitosan-coating-on-microemulsion-for-effective-dermal-clotrimazole-delivery
#19
Babita Kumari, Karthikeyan Kesavan
Clotrimazole (CTZ) is a broad spectrum antimycotic agent known to be very effective locally for the treatment of fungal skin infections. The aim of this study was to study the effect of chitosan-coated microemulsion (CME) for topical delivery of CTZ and also evaluate its in-vitro antifungal efficacy, Ex-vivo permeation and retention ability on the skin surface. The pseudo-ternary phase diagrams were developed using clove oil as oil phase, Tween 80 and propylene glycol as surfactant and co-surfactant, respectively and distilled water as aqueous phase...
August 30, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27566652/human-uterine-cervical-stromal-stem-cells-hucescs-why-and-how-they-exert-their-antitumor-activity
#20
REVIEW
José Schneider, Noemí Eiró, Román Pérez-Fernández, Anxo Martínez-Ordóñez, Francisco Vizoso
Our research team has recently isolated and characterized a new stromal stem cell line (hUCESCs) obtained from cytological smears, as routinely performed for cervical cancer screening. We have, furthermore, described that both hUCESCs directly, as well as the secretome contained in the conditioned medium used for growing them (hUCESCs-CM) have potent antitumoral, anti-inflammatory, antibiotic, antimycotic and re-epitheliasation-enhancing properties. The scientific explanation our team proposes for these pleiotropic effects are directly related to the site of origin of hUCESCs, the human cervical transition zone, which has unique features that biologically justify the different actions of hUCESCs and hUCESCs-CM...
September 2016: Cancer Genomics & Proteomics
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