keyword
MENU ▼
Read by QxMD icon Read
search

antimycotic

keyword
https://www.readbyqxmd.com/read/29774351/diversity-of-biologically-active-secondary-metabolites-from-endophytic-and-saprotrophic-fungi-of-the-ascomycete-order-xylariales
#1
REVIEW
Soleiman E Helaly, Benjarong Thongbai, Marc Stadler
Covering: up to December 2017The diversity of secondary metabolites in the fungal order Xylariales is reviewed with special emphasis on correlations between chemical diversity and biodiversity as inferred from recent taxonomic and phylogenetic studies. The Xylariales are arguably among the predominant fungal endophytes, which are the producer organisms of pharmaceutical lead compounds including the antimycotic sordarins and the antiparasitic nodulisporic acids, as well as the marketed drug, emodepside. Many Xylariales are "macromycetes", which form conspicuous fruiting bodies (stromata), and the metabolite profiles that are predominant in the stromata are often complementary to those encountered in corresponding mycelial cultures of a given species...
May 18, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/29755350/extracts-from-hypericum-hircinum-subsp-majus-exert-antifungal-activity-against-a-panel-of-sensitive-and-drug-resistant-clinical-strains
#2
Noemi Tocci, Daniele Perenzoni, Duilio Iamonico, Francesca Fava, Tobias Weil, Fulvio Mattivi
During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum includes many species that are used in the traditional medicine to treat pathological states like inflammations and infections caused by fungi. However, despite the diffused use of Hypericum -based products the antifungal potential of the genus is still poorly investigated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29753721/efficacy-of-modified-leeming-notman-media-in-a-resazurin-microtiter-assay-in-the-evaluation-of-in-vitro-activity-of-fluconazole-against-malassezia-furfur-atcc-14521
#3
F E Far, M M J Al-Obaidi, M N M Desa
BACKGROUND: Malassezia furfur is lipodependent yeast like fungus that causes superficial mycoses such as pityriasis versicolor and dandruff. Nevertheless, there are no standard reference methods to perform susceptibility test of Malassezia species yet. AIMS: Therefore, in this study, we evaluated the optimized culture medium for growth of this lipophilic yeast using modified leeming-Notman agar and colorimetric resazurin microtiter assay to assess antimycotic activity of fluconazole against M...
May 9, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29724290/determination-of-the-contamination-by-azole-antimycotics-in-hospital-and-house-sewage-a-pilot-project-for-the-city-of-dresden
#4
H Knoth, S Ihme, R Oertel, A Matthes, C Ritter
Medicininal compounds and their metabolites are known to end up in sewerage and may slip through the cleaning process. Azole antimycotics are frequently used in hospitals, in particular for patients with cancer or immunosuppression. The aim of the study was to determine whether measurable azole antimycotic concentrations were introducted in the sewarage drain of an acute care hospital with special interest in oncology and hematology and the extent of removal of antimycotics by the sewerage treatment plant. For this, the concentrations of three commonly used azole antimycotics were measured in the effluent of the sewerage drain at the University Hospital Dresden, as well as in the influent and effluent of the main sewerage treatment plant of the city...
May 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29705891/keratomycosis-due-to-tintelnotia-destructans-refractory-to-common-therapy-treated-successfully-with-systemic-and-local-terbinafine-in-combination-with-polyhexamethylene-biguanide
#5
Wolfgang J Behrens-Baumann, Wolfram Hofmüller, Ina Tammer, Kathrin Tintelnot
PURPOSE: To report on a wearer of rigid gas-permeable contact lenses with a keratomycosis due to Tintelnotia-a new genus of Phaeosphaeriaceae-treated with terbinafine and polyhexamethylene biguanide. METHODS: Chart review of a patient with fungal keratitis treated additionally with systemic and topical terbinafine 0.25% after symptoms increased under conventional antimycotic therapy with voriconazole. Antifungal susceptibility had been tested in vitro. RESULTS: After starting an additional treatment with systemic and topical terbinafine, the severe corneal infection was sufficiently resolved...
April 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29658325/fabrication-of-a-drug-delivery-system-that-enhances-antifungal-drug-corneal-penetration
#6
Jingguo Li, Zhanrong Li, Zhen Liang, Lei Han, Huayang Feng, Siyu He, Junjie Zhang
Fungal keratitis (FK) remains a severe eye disease, and effective therapies are limited by drug shortages and critical ocular barriers. Despite the high antifungal potency and broad spectrum of econazole, its strong irritant and insolubility in water hinder its ocular application. We designed and fabricated a new drug delivery system based on a polymeric vector for the ocular antifungal application of econazole. This novel system integrates the advantages of its constituent units and exhibits superior comprehensive performance...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29618337/gene-co-expression-networks-in-liver-and-muscle-transcriptome-reveal-sex-specific-gene-expression-in-lambs-fed-with-a-mix-of-essential-oils
#7
Marcella Sabino, Victor Adriano Okstoft Carmelo, Gianluca Mazzoni, Katia Cappelli, Stefano Capomaccio, Paolo Ajmone-Marsan, Andrea Verini-Supplizi, Massimo Trabalza-Marinucci, Haja N Kadarmideen
BACKGROUND: Essential oil (EO) dietary supplementation is a new strategy to improve animal health. EO compounds have antiparasitic, antimicrobial, antiviral, antimycotic, antioxidant and anti-inflammatory proprieties. Nutrigenomics investigations represent innovative approaches in understanding the relation between diet effect and gene expression related to the animal performance. Few nutrigenomics studies have used a high-throughput RNA-Sequencing (RNA-Seq) approach, despite great potential of RNA-Seq data in gene expression quantification and in co-expression network analyses...
April 4, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29596888/squalene-epoxidase-as-a-promising-metabolic-target-in-cancer-treatment
#8
Gabriella Cirmena, Paola Franceschelli, Edoardo Isnaldi, Lorenzo Ferrando, Marilena De Mariano, Alberto Ballestrero, Gabriele Zoppoli
Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its history since its discovery as an antimycotic target to its description as an emerging metabolic oncogene by amplification with clinical relevance in cancer. We review the published literature assessing the association between SE over-expression and poor prognosis in this disease...
March 26, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29578431/-case-report-of-candida-pneumonia
#9
A Toleuova, D Tayzhanova, R Toyynbekova, Zh Beysenbekova
Fungal pneumonia is considered as one of the most serious forms of pneumonia, the number of which has recently increased despite the use of new antimycotic drugs in pulmonology. Specificity of pathogens and torpid current of pneumomycosis represent great difficulties for accurate diagnosis and delay the timely onset of therapy, exacerbating inflammatory changes. In this article we present a rare case of isolated infection of the lungs parenchyma with Candida albicans in the form of focal pneumonia of the right lung lower lobe complicated by a clotted pleurisy...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29572043/bioluminescence-imaging-increases-in-vivo-screening-efficiency-for-antifungal-activity-against-device-associated-candida-albicans-biofilms
#10
Greetje Vande Velde, Soňa Kucharíková, Patrick Van Dijck, Uwe Himmelreich
Fungal infections are a major problem for a growing number of mostly immune-compromised patients. Candida albicans is an important human fungal pathogen causing mucosal and deep tissue infections of which the majority is associated with biofilm formation on medical implants. The animal models that are currently in use to test antifungal drugs are limited to ex vivo analyses, requiring host sacrifice that excludes longitudinal monitoring of dynamic processes during biofilm formation in the live host. As a solution, we introduce non-invasive, dynamic imaging and quantification of C...
March 20, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29548319/fungaemia-caused-by-obstructive-renal-candida-bezoars-leads-to-bilateral-chorioretinitis-a-case-report
#11
Johannes Stein, Stefan Latz, Jörg Ellinger, Guido Fechner, Maher Safi, Philipp Krausewitz, Simone Müller, Karin Weyer, Stefan C Müller
BACKGROUND: Renal fungal bezoars are remarkably rare and mostly occur in immunodeficient patients. Only a small number of cases with immunocompetent patients have been published so far. The published treatment approaches comprised systemic antimycotic therapy and surgical or minimal invasive removal of the fungal balls. In some cases irrigation of the renal duct system with amphotericin B was performed. By obstruction of the urinary tract bezoars can lead to infected hydronephrosis and severe urosepsis with high lethality...
March 16, 2018: BMC Urology
https://www.readbyqxmd.com/read/29531608/bullous-tinea-incognito-in-a-bulgarian-child-first-description-in-the-medical-literature
#12
Georgi Tchernev, Ivan Terziev
For the first time in the world medical literature, we describe a rare form of cutaneous dermatophytosis - a bullous form of Tinea incognito, classified by clinical picture, histopathological findings and an isolated infectious agent from the microbiological culture. After a thorough review of Medline/PubMed's relevant literature, we could not find similar cases of patients with Tinea incognito who are clinically presented with bullous lesions at the same time. Local application of corticosteroids in infants with unknown lesions may lead to progression of the underlying disease and may cause some serious problems in differential diagnosis aspect, while the clinical expression remains completely masked...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29518930/synthesis-molecular-docking-and-antimycotic-evaluation-of-some-3-acyl-imidazo-1-2-a-pyrimidines
#13
Omar Gómez-García, Dulce Andrade-Pavón, Elena Campos-Aldrete, Ricardo Ballinas-Indilí, Alfonso Méndez-Tenorio, Lourdes Villa-Tanaca, Cecilio Álvarez-Toledano
A series of 3-benzoyl imidazo[1,2- a ]pyrimidines, obtained from N -heteroarylformamidines in good yields, was tested in silico and in vitro for binding and inhibition of seven Candida species ( Candida albicans (ATCC 10231), Candida dubliniensis (CD36), Candida glabrata (CBS138), Candida guilliermondii (ATCC 6260), Candida kefyr , Candida krusei (ATCC 6358) and Candida tropicalis (MYA-3404)). To predict binding mode and energy, each compound was docked in the active site of the lanosterol 14α-demethylase enzyme (CYP51), essential for fungal growth of Candida species...
March 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29511942/the-evaluation-of-the-transport-medium-for-extracted-premolars-prior-to-cryopreservation-a-systematic-literature-review
#14
REVIEW
Noëmi M C De Roo, Laurent A M Thierens, Liesbeth Temmerman, Guy A M De Pauw
Prior to cryopreservation, a tooth is transported from a contaminated oral environment to the tooth bank. Our objective was to identify all studies reporting or investigating a transport protocol prior to the cryopreservation of teeth, in terms of decontamination of the subjects. The systematic literature search (1970-2017) was based on MEDLINE via PubMed, Web of Science and the Cochrane Library. The reference lists of the included studies and the Science Citation Index were used for hand searching (snowballing)...
March 7, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29503540/-origanum-vulgare-mediated-green-synthesis-of-biocompatible-gold-nanoparticles-simultaneously-possessing-plasmonic-antioxidant-and-antimicrobial-properties
#15
Daniela Benedec, Ilioara Oniga, Flavia Cuibus, Bogdan Sevastre, Gabriela Stiufiuc, Mihaela Duma, Daniela Hanganu, Cristian Iacovita, Rares Stiufiuc, Constantin Mihai Lucaciu
Purpose: The leaves and flowering stem of Origanum vulgare contain essential oils, flavonoids, phenolic acids and anthocyanins. We propose a new, simple, one-pot, O. vulgare extract (OVE) mediated green synthesis method of biocompatible gold nanoparticles (AuNPs) possessing improved antioxidant, antimicrobial and plasmonic properties. Materials and methods: Different concentrations of OVEs were used to reduce gold ions and to synthetize biocompatible spherical AuNPs...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29440895/biosynthesized-silver-and-gold-nanoparticles-are-potent-antimycotics-against-opportunistic-pathogenic-yeasts-and-dermatophytes
#16
Andrea Rónavári, Nóra Igaz, Mohana Krishna Gopisetty, Bettina Szerencsés, Dávid Kovács, Csaba Papp, Csaba Vágvölgyi, Imre Miklós Boros, Zoltán Kónya, Mónika Kiricsi, Ilona Pfeiffer
Background: Epidemiologic observations indicate that the number of systemic fungal infections has increased significantly during the past decades, however in human mycosis, mainly cutaneous infections predominate, generating major public health concerns and providing much of the impetus for current attempts to develop novel and efficient agents against cutaneous mycosis causing species. Innovative, environmentally benign and economic nanotechnology-based approaches have recently emerged utilizing principally biological sources to produce nano-sized structures with unique antimicrobial properties...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29422351/comparison-of-the-identification-results-of-candida-species-obtained-by-bd-phoenix%C3%A2-and-maldi-tof-bruker-microflex-lt-biotyper-3-1
#17
Andrea P Marucco, Patricia Minervini, Gabriela V Snitman, Adriana Sorge, Liliana I Guelfand, Laura López Moral
In patients with invasive fungal infections, the accurate and rapid identification of the genus Candida is of utmost importance since antimycotic sensitivity is closely related to the species. The aim of the present study was to compare the identification results of species of the genus Candida obtained by BD Phoenix™ (Becton Dickinson [BD]) and Maldi-TOF MS (Bruker Microflex LT Biotyper 3.1). A total of 192 isolates from the strain collection belonging to the Mycology Network of the Autonomous City of Buenos Aires, Argentina, were analyzed...
February 5, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29419783/inner-leaf-gel-of-aloe-striata-induces-adhesion-reducing-morphological-hyphal-aberrations
#18
Gloria Wada, Michael Vincent, Marcia Lee
Fungi, particularly molds that are cosmopolitan in soils, are frequent etiologic agents of opportunistic mycoses. Members of the Fusarium solani and Fusarium oxysporum species complexes are the most commonly implicated etiologic agents of opportunistic fusarial infections in mammals, while Paecilomyces variotii is one of the most frequently encountered Paecilomyces species in human infections. Prevention and treatment of these mycoses are problematic because available antimycotics are limited and often have toxic side effects...
February 8, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29371563/natural-antimicrobial-peptides-as-inspiration-for-design-of-a-new-generation-antifungal-compounds
#19
REVIEW
Małgorzata Bondaryk, Monika Staniszewska, Paulina Zielińska, Zofia Urbańczyk-Lipkowska
Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates...
August 26, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29371550/role-of-virulence-determinants-in-candida-albicans-resistance-to-novel-2-bromo-2-chloro-2-4-chlorophenylsulfonyl-1-phenylethanone
#20
Monika Staniszewska, Małgorzata Bondaryk, Zbigniew Ochal
We investigated the role of KEX2 , SAP4-6 , EFG1 , and CPH1 in the virulence of Candida under a novel compound 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone (Compound 4 ). We examined whether the exposure of C. albicans cells to Compound 4 , non-cytotoxic to mammalian cells, reduces their adhesion to the human epithelium. We next assessed whether the exposure of C. albicans cells to Compound 4 modulates the anti-inflammatory response (IL-10) and induces human macrophages to respond to the Candida cells...
June 24, 2017: Journal of Fungi (Basel, Switzerland)
keyword
keyword
32233
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"