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https://www.readbyqxmd.com/read/29321939/isolation-of-rickettsia-amblyommatis-in-huvec-line
#1
S Santibáñez, A Portillo, A M Palomar, J A Oteo
Rickettsia amblyommatis, formerly named Rickettsia amblyommii and 'Candidatus Rickettsia amblyommii' is an intracellular bacterium belonging to the spotted fever group Rickettsia. It is highly prevalent in Amblyomma americanum and in other Amblyomma spp. throughout the Western Hemisphere. R. amblyommatis has been cultivated in chicken fibroblast, primary embryonated chicken eggs, Vero cells and arthropod-derived cells. Because of the affinity of rickettsiae to invade vascular endothelial cells, we tried to isolate R...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29310303/a-novel-sensor-based-on-nanobiocomposite-au-in2o3-chitosan-modified-acetylene-black-paste-electrode-for-sensitive-detection-of-antimycotic-ciclopirox-olamine
#2
Hossieny Ibrahim, Yassien Temerk, Nasser Farhan
For the first time, a sensitive conductive nanobiocomposite sensor consisting of Au-In2O3 nanocomposite and chitosan (CS) was successfully prepared and used for the modification of acetylene black paste electrode (Au--In2O3--CS/ABPE). The phase structures, composition and morphology of Au-In2O3 nanocomposite were characterized by X-ray diffraction (XRD), energy-dispersed X-ray (EDX) and transmission electron microscopy (TEM). Electrochemical activities and surface analysis of the biosensor electrode Au--In2O3--CS/ABPE were investigated using scanning electron microscopy (SEM), cyclic voltammetry and square wave voltammetry...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29306005/preparation-characterization-and-antifungal-activity-of-iron-oxide-nanoparticles
#3
Shazia Parveen, Abdul Hamid Wani, Mohammad Ashraf Shah, Henam Sylvia Devi, Mohd Yaqub Bhat, Jahangir Abdullah Koka
Iron oxide nanoparticles with particle size 10-30 nm were prepared by a green approach using tannic acid as reducing and capping agent. These nanoparticles were characterized by X-ray diffractometry (XRD), high resolution field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The prepared iron oxide nanoparticles were also evaluated for their antifungal activity against Trichothecium roseum, Cladosporium herbarum, Penicillium chrysogenum, Alternaria alternata and Aspergillus niger...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29277007/singlet-oxygen-luminescence-kinetics-under-pdi-relevant-conditions-of-pathogenic-dermatophytes-and-molds
#4
Tobias Bornhütter, Nedaa Shamali, Irena Saltsman, Atif Mahammed, Zeev Gross, Georg Däschlein, Beate Röder
A treatment of onychomycosis using the photodynamic effect would be a favorable alternative to currently used antimycotic drugs. This study should be considered as a first step towards development and control of an efficient photodynamic inactivation of onychomycosis causative pathogens. Here, we evaluate the usage of time-resolved 2D singlet oxygen luminescence detection in combination with 2D fluorescence scanning as a tool to understand the behavior of the photosensitizer when applied to fungi on Petri dishes...
December 14, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29274212/drug-susceptibility-of-fungi-isolated-from-icu-patients
#5
Barbara D Modrzewska, Anna J Kurnatowska,, Katarzyna Khalid
Candida species can be a reason of infections associated with high morbidity and mortality. The risk of invasive candidosis for patients admitted to intensive care units (ICUs) is increased due to immunosuppressive states, prolonged length of stay, broad-spectrum antibiotics and Candida colonization. The aim of the study was to determine selected properties of fungi isolated from patients treated in the ICUs of hospitals in Lodz. The materials were collected from the oral cavity, the tracheostomy or endotracheal tube and urine from 16 children and 35 adult...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/29214974/insights-into-the-candidacidal-mechanism-of-ctn-15-34-a-carboxyl-terminal-crotalicidin-derived-peptide-related-to-cathelicidins
#6
Carolina Sidrim P Cavalcante, Francisca Lidiane Linhares de Aguiar, Raquel O S Fontenelle, Ramon Roseo de P P B de Menezes, Alice Maria Costa Martins, Cláudio B Falcão, David Andreu, Gandhi Rádis-Baptista
PURPOSE: Ctn[15-34], a carboxyl-terminal fragment of crotalicidin (a cathelicidin from the venom gland of a South American rattlesnake), has shown antifungal activity against clinical and standard strains of Candida species. The aim of the present work was to investigate the underlying mechanisms of the candidicidal activity of Ctn[15-34]. METHODOLOGY: The time-kill profile and drug synergism were evaluated by means of a microdilution assay and multi-parametric flow cytometry...
December 7, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29208486/controlled-release-biodegradable-nanoparticles-from-preparation-to-vaginal-applications
#7
Beatriz Martínez-Pérez, David Quintanar-Guerrero, Melina Tapia-Tapia, Ricardo Cisneros-Tamayo, María L Zambrano-Zaragoza, Sergio Alcalá-Alcalá, Néstor Mendoza-Muñoz, Elizabeth Piñón-Segundo
This study aimed to prepare poly (d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) with chitosan (CTS) surface modification to be used as a vaginal delivery system for antimycotic drugs. Clotrimazole was encapsulated with entrapment efficiencies of 86.1 and 68.9% into Clotrimazole-PLGA-NPs (CLT-PLGA-NPs) and PLGA-NPs with CTS-modified surface (CLT-PLGA-CTS-NPs), respectively. The later NPs exhibited a larger size and higher positive zeta potential (Z potential) in comparison to unmodified NPs. In vitro release kinetic studies indicated that Clotrimazole was released in percentages of >98% from both nanoparticulate systems after 18days...
December 2, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29199561/antifungal-antioxidative-and-genoprotective-properties-of-extracts-from-the-blushing-bracket-mushroom-daedaleopsis-confragosa-agaricomycetes
#8
Aleksandar Knežević, Mirjana Stajić, Lada Živković, Ivan Milovanović, Biljana Spremo-Potparević, Jelena Vukojević
This study aimed to evaluate the antifungal, antioxidative, and genoprotective potentials of various extracts of Daedaleopsis confragosa fruiting bodies and mycelia. The extracts exhibited weak fungistatic and an absence of any fungicidal activities against 7 important animal and human pathogens. Although mycelial extracts, especially the hot water extract, were more effective antifungal agents than basidiocarp extracts, they were significantly weaker than the commercial antimycotic ketoconazole. The tested extracts reduced DPPH radicals to various extents, depending on the material used for extraction and the solvent...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29183849/a-sterilization-method-for-decellularized-xenogeneic-cardiovascular-scaffolds
#9
Cátia Fidalgo, Laura Iop, Manuela Sciro, Michael Harder, Dimosthenis Mavrilas, Sotirios Korossis, Andrea Bagno, Giorgio Palù, Paola Aguiari, Gino Gerosa
Decellularized xenogeneic scaffolds have shown promise to be employed as compatible and functional cardiovascular biomaterials. However, one of the main barriers to their clinical exploitation is the lack of appropriate sterilization procedures. This study investigated the efficiency of a two-step sterilization method, antibiotics/antimycotic (AA) cocktail and peracetic acid (PAA), on porcine and bovine decellularized pericardium. In order to assess the efficiency of the method, a sterilization assessment protocol was specifically designed, comprising: i) controlled contamination with a known amount of bacteria; ii) sterility test; iii) identification of contaminants through MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization Time-of-Flight) mass spectrometry and iv) quantification by the Most Probable Number (MPN) method...
November 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29174867/the-synthesis-of-steroids-by-taenia-crassiceps-wfu-cysticerci-and-tapeworms-is-related-to-the-developmental-stages-of-the-parasites
#10
J M Patricio-Gómez, R A Valdez, A Veloz, L Aguilar-Vega, R Zurabian, M C Romano
Taeniids tapeworms are hermaphroditic helminths that gradually develop testis and ovaries in their reproductive units. The larval stage of the tapeworms named cysticercus is a vesicle that contains the scolex and proliferates asexually in the abdominal cavity of mice. Once in the host, they evaginate, attach to the gut and develop into an adult organism, the tapeworm. We have previously reported reported that T. crassiceps ORF and solium cysticerci transform steroid precursors to androgens and estrogens. Taenia crassiceps WFU cysticerci can also synthesize corticosteroids...
November 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29169813/-clinical-problems-in-medical-mycology-problem-number-51
#11
Mercedes Romero, Fernando Messina, Emmanuel Marín, Alicia Arechavala, Ricardo Negroni, Roxana Depardo, Laura Walker, Andrés Benchetrit, Gabriela Santiso
A 48 year-old immunocompetent woman, who had a nodular lesion in the neck and a dense infiltrate at the lower lobe of the left lung, presented at the Mycology Unit of Muñiz Hospital of Buenos Aires City. The pulmonary infiltrate disappeared spontaneously 3 months later. The histopathological study of the nodular lesion showed capsulated yeasts (mucicarmin and alcian blue positive stains) compatible with Cryptococcus. The mycological study of a new sample, obtained by a nodular puncture, allowed the isolation of yeasts, identified as Cryptococcus gattii (VGII)...
November 20, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29165092/synthesis-characterization-and-biological-activities-of-new-symmetric-bis-1-2-3-triazoles-with-click-chemistry
#12
Fatih Celik, Yasemin Unver, Burak Barut, Arzu Ozel, Kemal Sancak
BACKGROUND: 1,2,3-Triazole and its derivatives have important biological activities such as antimicrobial, anti-allergic, analgesic, anti-HIV, antiinflammatory, anticancer, antimalarial and antituberculosis. Other significant triazole derivatives are 1,2,4-triazoles which play a very important role in the medicinal chemistry due to the antiinflammatory, antimicrobial, antimigraine, anticancer, antimicrobial and antimycotic activities. In this study, we aimed to synthesize a new series of bis-1,2,3-triazole derivatives including 1,2,4-triazole to obtain more effective biological activities METHODS: In this study, a new series of bis-1,2,3-triazole compounds (9,10,11) were synthesized...
November 20, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29121650/flavin-containing-monooxygenase-3-fmo3-role-in-busulphan-metabolic-pathway
#13
Ibrahim El-Serafi, Ylva Terelius, Manuchehr Abedi-Valugerdi, Seán Naughton, Maryam Saghafian, Ali Moshfegh, Jonas Mattsson, Zuzana Potácová, Moustapha Hassan
Busulphan (Bu) is an alkylating agent used in the conditioning regimen prior to hematopoietic stem cell transplantation (HSCT). Bu is extensively metabolized in the liver via conjugations with glutathione to form the intermediate metabolite (sulfonium ion) which subsequently is degraded to tetrahydrothiophene (THT). THT was reported to be oxidized forming THT-1-oxide that is further oxidized to sulfolane and finally 3-hydroxysulfolane. However, the underlying mechanisms for the formation of these metabolites remain poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/29104569/a-linear-19-mer-plant-defensin-derived-peptide-acts-synergistically-with-caspofungin-against-candida-albicans-biofilms
#14
Tanne L Cools, Caroline Struyfs, Jan W Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H S Ramada, Carlos Bloch, Bruno P A Cammue, Karin Thevissen
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co-administered with caspofungin, the preferred antimycotic to treat such infections. In this study, we identified the smallest linear HsAFP1-derived peptide that acts synergistically with caspofungin or anidulafungin against C. albicans as HsLin06_18, a 19-mer peptide derived from the C-terminal part of HsAFP1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29103370/boerhaave-s-syndrome-complicated-by-a-saccharomyces-cerevisiae-pleural-empyema-case-report-and-review-of-the-literature
#15
Arno Teblick, Hilde Jansens, Karolien Dams, Francis J Somville, Philippe G Jorens
Objective and Importance Boerhaave's syndrome is a sudden and rare form of oesophageal rupture and is often complicated by local or systemic infection of the mediastinum or pleural cavity. Several micro-organisms are documented as cause of pleural empyema in patients with Boerhaave's syndrome. Intervention (& Technique) We report on a previously healthy 74-year-old male who was admitted at a regional hospital with severe retrosternal and abdominal pain after an episode of vigorous vomiting the morning after ingestion of large quantity of beer...
November 5, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29098663/antibiotics-reduce-retinal-cell-survival-in-vitro
#16
Amy E Lindsey, Ellen Townes-Anderson
Antibiotics such as gentamicin (an aminoglycoside) and penicillin (a beta-lactam antibiotic) are routinely used in retinal cell and explant cultures. In many cases, these in vitro systems are testing parameters regarding photoreceptor transplantation or preparing cells for transplantation. In vivo, milligram doses of gentamicin are neurotoxic to the retina. However, little is known about the effects of antibiotics to retina in vitro and whether smaller doses of gentamicin are toxic to retinal cells. To test toxicity, retinal cells were dissociated from tiger salamander, placed in culture, and treated with either 20 μg/ml gentamicin, 100 μg/ml streptomycin, 100 U/ml antibiotic/antimycotic, 0...
November 2, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29097225/effects-of-concurrent-vaginal-miconazole-treatment-on-the-absorption-and-exposure-of-nestorone%C3%A2-segesterone-acetate-and-ethinyl-estradiol-delivered-from-a-contraceptive-vaginal-ring-a-randomized-crossover-drug-drug-interaction-study
#17
Katharine B Simmons, Narender Kumar, Marlena Plagianos, Kevin Roberts, Elena Hoskin, Leo Han, Mohcine Alami, George Creasy, Bruce Variano, Ruth Merkatz
OBJECTIVES: To evaluate the effects of concurrent administration of three vaginal miconazole nitrate formulations on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol from a novel contraceptive vaginal ring (NES/EE CVR). STUDY DESIGN: This was an open-label, randomized, crossover, drug-drug interaction study conducted over three menstrual cycles in healthy women with regular menses. We compared systemic exposure to NES and EE by determining area under the curve (AUC8-21d) with CVR-only and CVR with each miconazole treatment...
October 30, 2017: Contraception
https://www.readbyqxmd.com/read/29034294/dataset-on-preparation-of-the-phosphorylated-counterparts-of-a-momordica-charantia-protein-for-studying-antifungal-activities-against-susceptible-dose-dependent-c-albicans-to-antimycotics
#18
Yuanbiao Qiao, Li Song, Chenchen Zhu, Qian Wang, Tianyan Guo, Yanhua Yan, Qingshan Li
The data presented here are related to a research article entitled "Development of a phosphorylated Momordica charantia protein system for inhibiting susceptible dose-dependent C. albicans to available antimycotics: An allosteric regulation of protein" (Qiao et al., 2017) [1]. The data set includes three portions: (1) a relationship between reaction velocities of protein phosphorylation as a function of the substrate concentrations, determined in enzymatic reactions in aid of protein kinases; (2) a result of antifungal susceptibility testing of C...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29031978/monitoring-the-phase-behavior-of-supersaturated-solutions-of-poorly-water-soluble-drugs-using-fluorescence-techniques
#19
Francesco Tres, Stephen D Hall, Michael A Mohutsky, Lynne S Taylor
Phase transformations of poorly water-soluble drugs, in low concentration, supersaturated aqueous solutions are of considerable interest. Herein, fluorescence lifetime and steady-state fluorescence spectroscopy were employed to investigate the fluorescence properties of the autofluorescent compound, felodipine (a 1,4-dihydropyridine calcium channel blocker), when present as free drug in solution, drug-rich aggregates and crystals. Measurements were also performed in the absence and presence of liver microsomes...
October 11, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29028561/stability-and-drug-release-studies-of-an-antimycotic-nanomedicine-using-hplc-dynamic-light-scattering-and-atomic-force-microscopy
#20
Ayako Watanabe, Mio Takagi, Shigeo Murata, Masaru Kato
Much attention has been paid to nanoparticle-based drug delivery systems to selectively deliver drugs to target organs and tissues. In this study, AmBisome, an antimycotic nanomedicine containing amphotericin B, was chosen as a typical nanomedicine, and analyzed using dynamic light scattering (DLS), an easy method to measure size, and size distribution, atomic force microscopy (AFM) and high-performance liquid chromatography (HPLC). AFM allowed the analysis of shape, besides a detailed size and size distribution...
September 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
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