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Invasive aspergilosis

Hirofumi Kato, Takuya Yamagishi, Tomoe Shimada, Tamano Matsui, Masayuki Shimojima, Masayuki Saijo, Kazunori Oishi
Although severe fever with thrombocytopenia syndrome (SFTS) was first reported from Japan in 2013, the precise clinical features and the risk factors for SFTS have not been fully investigated in Japan. Ninety-six cases of severe fever with thrombocytopenia syndrome (SFTS) were notified through the national surveillance system between April 2013 and September 2014 in Japan. All cases were from western Japan, and 82 cases (85%) had an onset between April and August. A retrospective observational study of the notified SFTS cases was conducted to identify the clinical features and laboratory findings during the same period...
2016: PloS One
Rosemary A Barnes, Kate Stocking, Sarah Bowden, Matthew H Poynton, P Lewis White
OBJECTIVES: The aim of this study was to assess the clinical utility of enhanced diagnostics on the management of invasive fungal disease in high risk patients within an integrated care pathway and to audit compliance and efficacy of antifungal prophylaxis. METHODS: A cohort of 549 high risk haematology and stem-cell transplant recipients was followed over a 5 year period. The routine standard of care involved the use of antimould prophylaxis and a neutropenic care pathway utilizing twice weekly antigen and PCR testing...
September 2013: Journal of Infection
Dita Paloušová, Martina Lengerová, Pavlína Volfová, Petr Bejdák, Iva Kocmanová, Jiří Mayer, Zdeněk Ráčil
Invasive fungal diseases (IFD) are a life-threatening infectious complications in immunocompromised patients and are associated with high rate of morbidity and mortality. The most common invasive mycosis in patients who underwent an allogeneic hematopoietic stem cell transplantation is invasive aspergilosis (IA), most frequently caused by the clinically dominant species Aspergillus fumigatus and, rarely, also by Aspergillus flavus, Aspergillus terreus and Aspergillus niger. In recent years, other related Aspergillus species were also reported to cause IFD, phenotypically similar to A...
August 2012: Klinická Mikrobiologie a Infekc̆ní Lékar̆ství
I Kaczmarek, J Bilska, K Osmola, M T Nowaczyk
INTRODUCTION: Mycotic infection of paranasal sinus could be the etiological factor of chronic sinusitis. The increase in number of fungal sinusitis cases have been reported recently among nonimmunocompromised patient after endodontic treatment of maxillary teeth. Nonspecific clinical signs and incorrect radiologic pictures interpretation as well as loss of therapeutic standards seems to be the cause of false negative diagnosis and difficulties in treatment of fungal sinusitis. AIM OF THE STUDY: Clinical and radiological picture of maxillary sinus aspergillosis was described in this paper...
June 2010: Otolaryngologia Polska
Z Muda, H Ibrahim, E J Abdulrahman, B S Menon, Z Zahari, A M Zaleha, A Talib
Invasive aspergillosis predominantly occurs in immunocompromised patients and is often resistant to different therapeutically strategies. However, mortality significantly increases if the central nervous system is affected. In this report we describe two cases of invasive aspergilosis, one with kidney involvement with a successful treatment while the other with pulmonary and cerebral involvement with a grave outcome.
December 2008: Medical Journal of Malaysia
Z Rácil, I Kocmanová, B Wagnerová, J Winterová, M Lengerová, M Moulis, J Mayer
UNLABELLED: PREMISES AND OBJECTIVES: Timely diagnosis is of critical importance for the prognosis of invasive aspergilosis (IA) patients. Over recent years, IA detection of galactomannan using the ELISA method has assumed growing importance. The objective of the study was to analyse the usability of the method in current clinical practice of a hemato-oncological ward. PATIENTS AND METHODS: From May 2003 to October 2006, blood samples were taken from patients at IA risk to detect galactomannan (GM) in serum using the ELISA method...
January 2008: Vnitr̆ní Lékar̆ství
E Fric, M Rehák, I Vlcková, S Burval, O Chrapek, J Rehák
The authors present a case report of a patient, in whom after a head injury the monolateral blindness occurred. Because of autoimmune thrombocytopeny the patient was treated with long-term corticosteroids. The clinical findings corresponded with the orbital apex syndrome. According to the results of the CT and MRI examinations, the sphenoidotomy was indicated, and the histological findings verified fragments of paranasal sinuses' aspergiloma. During the next course of the disease, despite antimycotic therapy, the progression of the aspergiloma in to the anterior cranial fossa occurred...
April 2007: Ceská a Slovenská Oftalmologie
Amy Kelaher
Invasive aspergillosis (IA) is a serious cause of morbidity and mortality among immunocompromised patients. Prompt and non-invasive methods for diagnosing IA are needed to improve the management of this life-threatening infection in patients with hematological disorders. In summary, this retrospective review of studies performed on the two assays finds that both assays have high sensitivity and specificity but are more useful when used together as a diagnostic strategy for patients with invasive aspergillosis...
2006: Clinical Laboratory Science: Journal of the American Society for Medical Technology
M R Burón Fernández, M J Oruezábal Moreno
The micotic aneurisms by Aspergillus are rare and usually appear in the context of an invasive pulmonary aspergilosis, or by septicum embolism or direct extension from the lungs, for that reason the location the more frequents is in aortic arch and the ascending aorta.8 cases of micotic aneurisms by Aspergillus spp. have been described in literature between 1966 and 2000, being the most frequent location the ascending aorta or the aortic arch. The Aspergillus fumigatus is the isolated species with more frequency, affecting mainly to patients undergoing inmunosupression...
September 2005: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
S Grau Cerrato, J Mateu-de Antonio, J Soto Alvarez, M A Muñoz Jareño, E Salas Sánchez, M Marín-Casino, C Rubio Terrés
OBJECTIVE: Invasive aspergillosis is an infection with high incidence and mortality. Voriconazole is a new antifungal agent that presents a high efficacy against Aspergillus. The aim of this evaluation was to carry out a pharmacoeconomic analysis of the use of voriconazole versus amphotericin B deoxycholate in the treatment of invasive aspergillosis in Spain. MATERIAL AND METHODS: A cost-effectiveness analysis has been performed by building a decision analytical model...
January 2005: Farmacia Hospitalaria
Guillermo Quindós, María Dolores Moragues, José Pontón
During the last decades, the use of antibody tests for the diagnosis of invasive mycoses has declined as a consequence of the general belief that they are insensitive and non-specific. However, there is a clear evidence that antibodies can be detected in highly immunodeficient patients (such as bone marrow transplant recipients), and that those antibodies are useful for the diagnosis. Antibody tests are currently in use as diagnostic tools for some primary mycoses, such as the endemic mycoses, aspergilloma, allergic bronchopulmonary aspergilosis and sporothrichosis...
March 2004: Revista Iberoamericana de Micología
P Tattevin, S Jauréguiberry, J-P Gangneux
INTRODUCTION: The brain is almost always a localization of invasive aspergillosis, after hematogenous spread from pulmonary aspergillosis. Brain aspergilosis is not rare and is one of the worst prognosis factors of invasive aspergillosis. STATE OF ART: The incidence of this severe mycosis is currently on the rise due to the development of major immunosuppressive treatments. Brain aspergillosis is noteworthy for its vascular tropism, leading to infectious cerebral vasculitis, mainly involving thalamoperforating and lenticulostriate arteries, with a high frequency of thalamic or basal nuclei lesions...
May 2004: Revue Neurologique
Juan Luis Rodríguez-Tudela, Manuel Cuenca-Estrella, Emilia Mellado, Araceli Monzón
During the second part of xx century, the prevalence of fungal infections has raised inexorably. The main cause has been the increase of number of immunosupressed patients and the new aggressive therapeutic approaches. Since 1970, the annual incidence of candidosis and aspergilosis has increased 40 and 6.5 times, respectively. Additional studies reported in USA and Europe indicated that Candida produce between 5-10% of all episodes of nosocomial sepsis. In this revision, we analyse the present situation of Medical Mycology including the most relevant aspects as: a) the increase of incidence in fungal infections; b) the problems of the diagnosis including classical and new methodologies and antifungal susceptibility testing, and c) the uncertainties of the treatment due to the arrival of new formulations and new antifungalsThe future of Medical Mycology depends in many factors but molecular biology will play the central role although this discipline will develop slower than other microbiology areas as virology or bacteriology...
May 2003: Enfermedades Infecciosas y Microbiología Clínica
M Siemann, M Koch-Dörfler
The sensitivity of a sandwich enzyme-linked immunosorbent assay (ELISA) for detecting Aspergillus galactomannan was evaluated with 66 serum samples and 113 specimens of the respiratory tract obtained from 52 patients with pulmonary diseases. The patients were divided into five groups: proven invasive pulmonary aspergillosis (IPA) (five patients), probable IPA (seven patients), Aspergillus colonization (eight patients) or unlikely Aspergillus infection (27 patients). Another five patients with doubtful diagnostic test results are discussed in detail...
2001: Mycoses
P Germaud, A Haloun
Immunodepressed patients, particularly those with neutropenia or bone marrow or organ grafts, are at risk of developing nosocomial invasive pulmonary aspergilosis. The favoring factors, early diagnostic criteria and curative treatment protocols are well known. Prognosis remains however quite severe with a death rate above 50%. Preventive measures are required for the treatment of these high-risk patients and epidemiology surveillance is needed in case of aspergillosis acquired in the hospital.
April 2001: Revue de Pneumologie Clinique
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