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Cerebral aspergillosis

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https://www.readbyqxmd.com/read/28932128/a-suspected-case-of-autoinduction-of-voriconazole-metabolism-in-a-patient-with-cerebral-aspergillosis
#1
Martin J Ferguson, Maria L Randles, Declan G de Freitas
OBJECTIVE: This study aims to report a case of accelerated metabolism of voriconazole in a patient with cerebral aspergillosis. CASE SUMMARY: A 36-year-old woman developed cerebral aspergillosis after immunosuppressive treatment for suspected atypical hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. She was treated with voriconazole using therapeutic drug monitoring to guide dosing. After an initial high level, her dose was reduced, but over the following weeks, she required several dose increases in order to achieve a voriconazole level within the target range...
2017: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/28892898/atypical-presentation-of-isolated-cerebral-aspergillosis-in-a-renal-allograft-recipient
#2
Minaxi H Patel, Aruna V Vanikar, Himanshu V Patel, Rashmi D Patel
The immunosuppressive state in organ transplantation leads to infectious complications responsible for high mortality rate. Fungal infections account for 5% of all infections in Renal Transplantation (RT) recipients. Aspergillus species are filamentous fungi frequently causing fungal infections in RT recipients. Lungs and paranasal sinuses are the usual portal of entry from where it disseminates to other organs. Here, we are reporting a case of 14-year-old boy with RT from mother's kidney, who had atypical presentation of isolated cerebral aspergillosis at 19 months post-transplant without identified portal of entry...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28781322/cerebral-air-embolism-from-chronic-progressive-pulmonary-aspergillosis
#3
Hayato Yabe, Soichirou Watanabe, Atsushi Saito, Masami Yamazoe
No abstract text is available yet for this article.
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28774170/an-autopsy-case-of-epstein-barr-virus%C3%A2-associated-diffuse-large-b-cell-lymphoma-of-the-central-nervous-system-in-an-immunocompromised-host
#4
Sun-Young Park, Seong Ik Kim, Hannah Kim, Yoojin Lee, Sung-Hye Park
Lymphomas arising in the central nervous system (CNS) of immunocompromised hosts represent non-Hodgkin's lymphomas exclusively associated with Epstein-Barr virus (EBV). Here we report an autopsy case of EBV-associated CNS diffuse large B-cell lymphoma (DLBCL) in a host suffering from systemic lupus erythematosus who underwent immunosuppressive therapy. After autopsy, EBV-associated CNS DLBCL as well as pulmonary mixed aspergillosis and Pneumocystis jirovecii pneumonia were added to the clinical impressions of complicated pneumonia and cerebral hemorrhage in this immunocompromised patient...
August 4, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28770205/fatal-mycotic-aneurysm-of-the-basilar-artery-caused-by-aspergillus-fumigatus-in-a-patient-with-pituitary-adenoma-and-meningitis
#5
Martin Winterholler, Roland Coras, Walter Geißdörfer, Rudolf Rammensee, Philipp Gölitz, Christian Bogdan, Roland Lang
Fungal infections of the central nervous system (CNS) frequently occur in immunosuppressed patients. Here, we describe the case of an immunocompetent 64-year-old man who presented with diplopia, right-sided hemiparesis, and a mild headache after cleaning and replacing nesting boxes of wild birds during the preceding months. Lumbar puncture revealed pleocytosis, elevated protein, and lactate levels in the cerebrospinal fluid (CSF). Initial imaging showed ischemia in the left thalamus and an enlargement of the sellar region...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28642144/performance-of-aspergillus-pcr-in-cerebrospinal-fluid-for-the-diagnosis-of-cerebral-aspergillosis
#6
S Imbert, J-Y Brossas, M Palous, I Joly, I Meyer, A Fekkar
OBJECTIVES: Cerebral aspergillosis is a rare but often fatal form of invasive aspergillosis that remains difficult to diagnose. The literature has shown the value of Aspergillus PCR in blood-derived samples for the diagnosis of invasive aspergillosis but provides far less information for cerebrospinal fluid (CSF) in cerebral aspergillosis. Here, we evaluated the usefulness of an Aspergillus PCR assay performed on CSF for the diagnosis of cerebral aspergillosis. METHODS: This retrospective study involved 72 patients with suspected cerebral aspergillosis for a total of 88 CSF samples in whom CSF Aspergillus PCR was performed...
November 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28552326/ibrutinib-in-pcnsl-the-curious-cases-of-clinical-responses-and-aspergillosis
#7
COMMENT
Christian Grommes, Anas Younes
In this issue of Cancer Cell, Lionakis et al. demonstrate that the combination of temozolomide, etoposide, doxorubicin, dexamethasone, rituximab, and the Bruton tyrosine kinase (BTK) inhibitor ibrutinib induced frequent responses in patients with primary central nervous system lymphoma but was associated with significant toxicity, including pulmonary and cerebral aspergillosis infections.
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28484525/invasive-aspergillus-sinusitis-with-orbitocranial-extension
#8
Saleh S Baeesa, Rakan F Bokhari, Khalid B Alghamdi, Hisham B Alem, Jaudah A Al-Maghrabi, Tariq A Madani
CONTEXT: Invasive sinonasal aspergillosis is a silently progressive disease that, left untreated, may invade the adjacent intracranial and intra-orbital compartments incurring serious morbidity. AIM: To evaluate our results of a collaborative surgical management plans for patients with invasive sinonasal aspergillosis with orbitocranial extension. SETTING AND DESIGN: Retrospective study. MATERIALS AND METHODS: Between the years 2000 and 2012, 12 patients with Aspergillus sinusitis with orbitocranial extension were treated at our institution...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28471899/angioinvasive-aspergillus-associated-stroke-in-an-immunocompetent-host-following-cardiac-surgery-and-ecmo
#9
Tapan Kavi, Nikhil Madan, Tamara Majic, Axel Rosengart, Marcel Maya, Serguei Bannykh, Shouri Lahiri
INTRODUCTION: Invasive cerebral aspergillosis is an uncommon cause of stroke among immunocompetent patients and has not been reported in association with cardiac surgery or extracorporeal membrane oxygenation (ECMO). We report the case of an immunocompetent host who developed aspergillus-associated stroke following coronary artery bypass graft (CABG) and ECMO. CASE REPORT: A 59-year-old woman developed cardiogenic shock after 3-vessel-CABG requiring intra-aortic balloon pump placement and subsequent veno-arterial ECMO...
May 2017: Neurologist
https://www.readbyqxmd.com/read/28265376/slowly-progressive-invasive-rhino-orbito-cerebral-aspergillosis-case-report-and-literature-review
#10
Giselle de Martin Truzzi, Henrique Furlan Pauna, Igor Moreira Hazboun, Igor Benedick Coimbra, Emerson Taro Inoue Sakuma, Icléia Siqueira Barreto, Carlos Takahiro Chone, Eulalia Sakano
This is a report of a patient with aspergillosis infection, which was thought to be a tumoral lesion during its investigation. This is not a common disease in Western countries, and this report should increase our awareness for differential diagnosis of nasal masses. Early diagnosis is desired in order to increase the survival rates.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28169858/central-nervous-system-infections-in-immunocompromised-patients
#11
Romain Sonneville, Eric Magalhaes, Geert Meyfroidt
PURPOSE OF REVIEW: Although rare, central nervous system (CNS) infections are increasingly being recognized in immunocompromised patients. The goal of the present review is to provide a practical diagnostic approach for the intensivist, and to briefly discuss some of the most prevalent conditions. RECENT FINDINGS: Immunocompromised patients presenting with new neurological symptoms should always be suspected of a CNS infection. These infections carry a poor prognosis, especially if intracranial hypertension, severely altered mental status or seizures are present...
April 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28068928/newly-recognized-cerebral-infarctions-on-postmortem-imaging-a-report-of-three-cases-with-systemic-infectious-disease
#12
Sakon Noriki, Kazuyuki Kinoshita, Kunihiro Inai, Toyohiko Sakai, Hirohiko Kimura, Takahiro Yamauchi, Masayuki Iwano, Hironobu Naiki
BACKGROUND: Postmortem imaging (PMI) refers to the imaging of cadavers by computed tomography (CT) and/or magnetic resonance imaging (MRI). Three cases of cerebral infarctions that were not found during life but were newly recognized on PMI and were associated with severe systemic infections are presented. CASE PRESENTATIONS: An 81-year-old woman with a pacemaker and slightly impaired liver function presented with fever. Imaging suggested interstitial pneumonia and an iliopsoas abscess, and blood tests showed liver dysfunction and disseminated intravascular coagulation (DIC)...
January 10, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28053849/long-term-outcome-of-medical-and-surgical-co-management-of-craniospinal-aspergillosis-in-an-immunocompromised-patient
#13
Dipu Sathyapalan, Sabarish Balachandran, Anil Kumar, Bindu Mangalath Rajamma, Ashok Pillai, Vidya P Menon
35 yr old steroid dependent lady with Pulmonary TB underwent debridement of epidural abscess & posterior stabilization for paraparesis. With histopathology and cultures showing Aspergillus fumigatus, voricanozole was started. By the fourth week, she developed persistent fever, and altered mental status. Brain MRI and CSF study including multiplex PCR evaluation confirmed cerebral aspergillosis. Voricanozole was changed to intravenous lipid complex Amphotericin B to achieve sustained clinical and radiological response after six months of therapy...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27936983/molecular-diagnosis-of-invasive-mycoses-of-the-central-nervous-system
#14
REVIEW
Matthew William McCarthy, Thomas J Walsh
In September 2012, the Centers for Disease Control and Prevention (CDC) began investigating an outbreak of fungal meningitis among patients who had received contaminated preservative-free methyl prednisolone acetate injections from the New England Compounding Center in Framingham, Massachusetts. Thousands of patients were potentially exposed to tainted corticosteroids, but establishing the diagnosis of fungal meningitis during the nationwide outbreak was difficult because little was known about the natural history of the disease...
February 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27695571/resolution-of-aspergillosis-in-neuroimaging-of-an-immunocompromised-patient-with-pulmonary-and-cerebral-lesions
#15
Mohsen Meidani, Atousa Hakamifard, Amir Hossein Sarrami
Central nervous system (CNS) aspergillosis is uncommon and considered the most lethal form of aspergillosis. Indeed, current therapeutic strategies such as combination antifungal regimen, neurosurgical resection of infected tissue, and removal of infection source fail to improve the unsatisfactory prognosis of CNS aspergillosis in the majority of the patients. The authors describe a case of chronic pulmonary aspergillosis with concomitant CNS lesions that dramatically responded to antifungal therapy and the CNS lesions resolved in follow-up imaging...
October 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27399315/successful-treatment-of-cerebral-aspergillosis-in-a-patient-with-acquired-immune-deficiency-syndrome
#16
J Luo, X Wang, Y Yang, T Lan, M A Ashraf, Q Mao
We report a case of a patient with AIDS and a brain abscess caused by aspergillus, who underwent neurosurgical excision of the lesion and received subsequent therapy with voriconazole. The patient suffered from intracranial hypertension and visual disorders.
December 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27333836/cerebral-aspergillosis-in-a-patient-with-pulmonary-tuberculosis
#17
Despoina Voultsinou, Georgios Matis, Danilo Silva, Olga Chrysou, Theodossios Birbilis, Panagiotis Palladas, Triantafillos Geroukis
No abstract text is available yet for this article.
September 2015: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27308089/cerebral-aspergillosis-and-pulmonary-tuberculosis-in-a-child-with-chronic-granulomatous-disease
#18
Muhammed Waqas, Sidra Zafar, Tooba Rehman, Muhammed Riyaz, Muhammed E Bari, Romana Idrees
BACKGROUND: Chronic granulomatous disease (CGD) is an immune disorder that affects phagocytes. It is characterized by recurrent or persistent bacterial and fungal infections. Reports of tuberculosis (TB) in patients with CGD are rare. In developing countries, where TB is endemic, possibility of other chronic infections is often overlooked by physicians. CASE DESCRIPTION: We report the case of a 4-year-old boy who had recurrent respiratory infections and episodes of headache...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27097323/magnetic-resonance-imaging-of-cerebral-aspergillosis-imaging-and-pathological-correlations
#19
Guillaume Marzolf, Marcela Sabou, Béatrice Lannes, François Cotton, David Meyronet, Damien Galanaud, Jean-Philippe Cottier, Sylvie Grand, Hubert Desal, Julie Kreutz, Maleka Schenck, Nicolas Meyer, Francis Schneider, Jean-Louis Dietemann, Meriam Koob, Raoul Herbrecht, Stéphane Kremer
Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis and correlated them to the immune status of the patients and to neuropathological findings when tissue was available. The lesions were characterized by their number, topography, and MRI signal. Dissemination to the brain resulted from direct spread from paranasal sinuses in 8 patients, 6 of them being immunocompetent...
2016: PloS One
https://www.readbyqxmd.com/read/26978276/cerebral-aspergillosis-a-retrospective-analysis-of-eight-cases
#20
Ruo-Xi Wang, Jia-Tang Zhang, Yu Chen, Xu-Sheng Huang, Wei-Quan Jia, Sheng-Yuan Yu
PURPOSE: Aspergillosis of the central nervous system is very rare. However with recent increases in the use of immunosuppressive agents and antibiotics, its incidence is increasing. We evaluated the demographics, clinical manifestations, laboratory findings, diagnosis, underlying conditions, treatment regimens and outcomes of patients with cerebral aspergillosis (CA). METHODS: We retrospectively reviewed data from eight patients with CA hospitalized at a Chinese general hospital from 1 January 2005 to 30 September 2015...
April 2017: International Journal of Neuroscience
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