Read by QxMD icon Read

Cerebral aspergillosis

Mohsen Meidani, Atousa Hakamifard, Amir Hossein Sarrami
Central nervous system (CNS) aspergillosis is uncommon and considered the most lethal form of aspergillosis. Indeed, current therapeutic strategies such as combination antifungal regimen, neurosurgical resection of infected tissue, and removal of infection source fail to improve the unsatisfactory prognosis of CNS aspergillosis in the majority of the patients. The authors describe a case of chronic pulmonary aspergillosis with concomitant CNS lesions that dramatically responded to antifungal therapy and the CNS lesions resolved in follow-up imaging...
October 2016: Asian Journal of Neurosurgery
J Luo, X Wang, Y Yang, T Lan, M A Ashraf, Q Mao
We report a case of a patient with AIDS and a brain abscess caused by aspergillus, who underwent neurosurgical excision of the lesion and received subsequent therapy with voriconazole. The patient suffered from intracranial hypertension and visual disorders.
April 18, 2016: West Indian Medical Journal
Despoina Voultsinou, Georgios Matis, Danilo Silva, Olga Chrysou, Theodossios Birbilis, Panagiotis Palladas, Triantafillos Geroukis
No abstract text is available yet for this article.
September 2015: Acta Neurologica Taiwanica
Muhammed Waqas, Sidra Zafar, Tooba Rehman, Muhammed Riyaz, Muhammed E Bari, Romana Idrees
BACKGROUND: Chronic granulomatous disease (CGD) is an immune disorder that affects phagocytes. It is characterized by recurrent or persistent bacterial and fungal infections. Reports of tuberculosis (TB) in patients with CGD are rare. In developing countries, where TB is endemic, possibility of other chronic infections is often overlooked by physicians. CASE DESCRIPTION: We report the case of a 4-year-old boy who had recurrent respiratory infections and episodes of headache...
2016: Surgical Neurology International
Guillaume Marzolf, Marcela Sabou, Béatrice Lannes, François Cotton, David Meyronet, Damien Galanaud, Jean-Philippe Cottier, Sylvie Grand, Hubert Desal, Julie Kreutz, Maleka Schenck, Nicolas Meyer, Francis Schneider, Jean-Louis Dietemann, Meriam Koob, Raoul Herbrecht, Stéphane Kremer
Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis and correlated them to the immune status of the patients and to neuropathological findings when tissue was available. The lesions were characterized by their number, topography, and MRI signal. Dissemination to the brain resulted from direct spread from paranasal sinuses in 8 patients, 6 of them being immunocompetent...
2016: PloS One
Ruo-Xi Wang, Jia-Tang Zhang, Yu Chen, Xu-Sheng Huang, Wei-Quan Jia, Sheng-Yuan Yu
PURPOSE: Aspergillosis of the central nervous system is very rare. However with recent increases in the use of immunosuppressive agents and antibiotics, its incidence is increasing. We evaluated the demographics, clinical manifestations, laboratory findings, diagnosis, underlying conditions, treatment regimens and outcomes of patients with cerebral aspergillosis (CA). METHODS: We retrospectively reviewed data from eight patients with CA hospitalized at a Chinese general hospital from 1 January 2005 to 30 September 2015...
March 15, 2016: International Journal of Neuroscience
Hung-Jen Tang, Wei-Lun Liu, Tsung Chain Chang, Ming-Chi Li, Wen-Chien Ko, Chi-Jung Wu, Yin-Ching Chuang, Chih-Cheng Lai
Invasive cerebral aspergillosis always developed in immunocompromised host. Early diagnosis may save life in this critical condition; however, it is difficult to reach. Herein, we presented an unusual case of invasive cerebral aspergillosis in a cirrhotic patient. A 47-year-old man presented with progressive deterioration of consciousness for three days. The patient had a history of alcoholic liver cirrhosis, Child-Pugh class C. Magnetic resonance imaging (MRI) of brain showed multi-focal parenchymal lesions, which was consistent with multiple brain abscesses...
March 2016: Medicine (Baltimore)
Jonathan Richard Ellenbogen, Mueez Waqar, Richard P D Cooke, Mohsen Javadpour
Cerebral aspergillosis, is an infrequent, opportunistic infection of the central nervous system that accounts for 5-10% of all intracranial fungal pathology. It is uncommon in immunocompetent patients and has a significant disease burden, with high morbidity and mortality, even with appropriate treatment. Basic principles of abscess management should be employed, including aspiration and targeted anti-fungal therapy for 12-18 months. However, reported outcomes with a purely minimally invasive approach are poor and there should be a low threshold for surgical excision, especially in resource poor settings and in patients with deteriorating neurology harbouring sizeable masses...
June 2016: British Journal of Neurosurgery
Shailendra Shrestha, John Kanellis, Tony Korman, Kevan R Polkinghorne, Fiona Brown, Ming Yii, Peter G Kerr, William Mulley
AIM: Nocardia infections are an uncommon but important cause of morbidity and mortality in renal transplant recipients. The present study was carried out to determine the spectrum of Nocardia infections in a renal transplant centre in Australia. METHODS: A retrospective chart analysis of all renal transplants performed from 2008 to 2014 was conducted to identify cases of culture proven Nocardia infection. The clinical course for each patient with nocardiosis was examined...
March 2016: Nephrology
G M Chong, J A Maertens, K Lagrou, G J Driessen, J J Cornelissen, B J A Rijnders
Testing cerebrospinal fluid (CSF) for the presence of galactomannan (GM) antigen may help in diagnosing cerebral aspergillosis (CA). However, the use of the CSF GM test as a diagnostic test has been little studied. We evaluated its diagnostic performance by comparing the CSF GM optical density indexes (ODI) at different cutoffs in patients with probable and proven CA to those in patients without CA. Patients from 2 tertiary referral hospitals with suspected CA between 2004 and 2014 and in whom CSF GM ODI had been determined were selected...
February 2016: Journal of Clinical Microbiology
Tae-Seok Kim, Keun Soo Ahn, Yong Hoon Kim, Hyoung Tae Kim, Byoung Kuk Jang, Jae Seok Hwang, Il-Man Kim, Yu Na Kang, Koo Jeong Kang
Invasive aspergillosis is one of the most important and fatal complications after liver transplant, especially in patients with involvement of the central nervous system. We present a case of a patient who developed cerebral and pulmonary aspergillosis, coinfected with cytomegalovirus, after liver transplant for toxic fulminant hepatitis. The patient was treated successfully with neurosurgical intervention and voriconazole. Voriconazole is considered more effective in cerebral aspergillosis than other anti-fungal agents due to the greater penetration into central nervous system and higher cerebrospinal fluid and brain tissue levels...
February 18, 2015: Experimental and Clinical Transplantation
Seyedmojtaba Seyedmousavi, Jacques Guillot, Pascal Arné, G Sybren de Hoog, Johan W Mouton, Willem J G Melchers, Paul E Verweij
The importance of aspergillosis in humans and various animal species has increased over the last decades. Aspergillus species are found worldwide in humans and in almost all domestic animals and birds as well as in many wild species, causing a wide range of diseases from localized infections to fatal disseminated diseases, as well as allergic responses to inhaled conidia. Some prevalent forms of animal aspergillosis are invasive fatal infections in sea fan corals, stonebrood mummification in honey bees, pulmonary and air sac infection in birds, mycotic abortion and mammary gland infections in cattle, guttural pouch mycoses in horses, sinonasal infections in dogs and cats, and invasive pulmonary and cerebral infections in marine mammals and nonhuman primates...
November 2015: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Daniel Beraldo, Ramon Guerra, Vinícius Alvarenga, Letícia Crepaldi
Aspergillosis is a disease that predominantly affects immunocompromised patients. The incidence in immunocompetents is rare, and manifestation is generally pulmonary. Few reports in the literature refer to isolated cerebral aspergillosis in individuals with no chronic comorbidities. We describe a case of a 59-year-old rural worker without previous pathologies who had a partial convulsive crisis in a subtle form, with self-limiting and nonrecurrent secondary generalization. Diagnostic investigation demonstrated a subcortical tumorlike lesion in the right precentral gyrus by nuclear magnetic resonance that allowed en bloc microsurgical resection, with histopathologic findings indicating cerebral aspergillosis...
September 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Robert Y Shih, Kelly K Koeller
Despite remarkable progress in prevention and treatment, infectious diseases affecting the central nervous system remain an important source of morbidity and mortality, particularly in less-developed countries and in immunocompromised persons. Bacterial, fungal, and parasitic pathogens are derived from living organisms and affect the brain, spinal cord, or meninges. Infections due to these pathogens are associated with a variety of neuroimaging patterns that can be appreciated at magnetic resonance imaging in most cases...
July 2015: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Tomoko Okazaki, Shoichi Shiraishi, Naoki Iwasa, Emi Kitamura, Tetsu Mizutani, Yukiko Hanada, Takehiko Yanagihara
Central nervous system (CNS) aspergillosis with stroke has a high mortality and poor prognosis generally. We report a 78-years-old woman with diabetes mellitus, who developed invasive paranasal sinus aspergillosis with the orbital apex syndrome on the right side and cerebral infarction caused by intracranial occlusion of the right internal carotid artery. Based on the presence of a mass lesion in the ethmoid sinus extending to the orbital apex on the right side with cranial CT, the mass lesion was surgically removed and the pathological examination of the surgical specimen revealed aspergillus mold...
2015: Rinshō Shinkeigaku, Clinical Neurology
Manish Sadarangani, Melissa Harvey, Allison McDonald, David P Speert, David Dix
We present the case of a 3-year-old boy who was diagnosed with cerebral abscesses due to Aspergillus nidulans infection on day 28 of induction chemotherapy for acute lymphoblastic leukemia. He responded well to treatment with voriconazole and caspofungin, making a full recovery. There are very few cases of invasive aspergillosis reported in children during induction chemotherapy for acute leukemia and A. nidulans is rare in the absence of chronic granulomatous disease.
August 2015: Journal of Pediatric Hematology/oncology
Soubhagya Ranjan Tripathy, Sudhanshu Sekhar Mishra, Rama Chandra Deo, Itibrata Mohanta, Kalpalata Tripathy
BACKGROUND: Cerebral aspergillosis, often encountered in immunocompromised patients, is almost always fatal despite radical surgical and medical management and frequently is a finding at autopsy. Attempts at fungal isolation often are unsuccessful, and a high index of radiologic suspicion is necessary. CASE DESCRIPTION: A premature, 5-month-old female infant, born via normal vaginal delivery, presented with a progressive increase in head size since birth, delayed developmental milestones, and intermittent vomiting for 1 month...
November 2015: World Neurosurgery
Xiaohui Liu, Wanrun Lin, Yongxiang Wang, Zhou Wang, Yifeng Du
No abstract text is available yet for this article.
September 2015: Neurological Sciences
Andreia Matas, Andreia Veiga, João Paulo Gabriel
No abstract text is available yet for this article.
January 2015: Revista da Sociedade Brasileira de Medicina Tropical
Fulvia Mazzaferri, Irene Adami, Pierluigi Tocco, Angelo Cazzadori, Mara Merighi, Alberto Forni, Silvia Storato, Sergio Ferrari, Ercole Concia
Cerebral aspergillosis is a rare and highly fatal infection that mainly affects immunocompromised patients. We report on a case of a heart transplanted Caucasian man, who arrived at our hospital because of the onset of diplopy. We performed a broad diagnostic work-up: the brain MRI showed a single ring-enhancing thalamo-mesencephalic area suggestive of abscess lesion; cerebrospinal fluid (CSF) analysis disclosed galactomannan and beta-D-glucan antigens. Thus the antifungal therapy was immediately started. We decided to discontinue the therapy 16 months later because of severe hepatic toxicity, given that the patient was persistently asymptomatic, brain imaging showed a progressive resolution of the abscess area and CSF antigen analysis was persistently negative...
March 2015: Le Infezioni in Medicina
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"