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https://www.readbyqxmd.com/read/28933622/risk-and-impact-of-herpes-zoster-on-patients-with-diabetes-a-population-based-study-2009-2014
#1
Cintia Muñoz-Quiles, Mónica López-Lacort, F Javier Ampudia-Blasco, Javier Díez-Domingo
AIMS: This study was designed to assess the impact of diabetes on the risk and severity of herpes zoster (HZ), and the impact of HZ on diabetes. It focused primarily on immunocompetent patients aged ≥ 50 years who would be eligible for preventive vaccination. METHODS: Using population and healthcare databases of Valencia Region (Spain), a retrospective cohort of all subjects ≥ 50 years was followed up between 2009 and 2014. HZ and diabetes were defined using ICD-9 codes...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28905082/-attenuated-zoster-vaccine-is-not-recommended-as-a-standard-vaccine-missed-opportunity-or-logical-implementation-of-the-evidence-based-approach-of-the-standing-committee-on-vaccination
#2
EDITORIAL
Klaus Überla
No abstract text is available yet for this article.
September 13, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28903515/update-from-the-advisory-committee-on-immunization-practices
#3
Sean T O'Leary, Yvonne A Maldonado, Carrie L Byington
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (C...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28895088/prevalence-of-a-history-of-prior-varicella-herpes-zoster-infection-in-multiple-sclerosis
#4
Ali Manouchehrinia, Radu Tanasescu, Huner Kareem, Oltita P Jerca, Fouzia Jabeen, Rachelle Shafei, Judith Breuer, Keith Neal, William Irving, Cris S Constantinescu
Varicella zoster virus (VZV) infection has been implicated in multiple sclerosis (MS), but direct causal involvement has been disputed. Nevertheless, knowledge of VZV exposure is important, given the risk of serious complications of first exposure while undergoing immunosuppressive treatment, in particular with fingolimod. We distributed questionnaires to MS clinic patients, requesting information about history of chickenpox, sibling/household/occupational exposure, history of zoster (shingles), and disease-modifying treatment...
September 11, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28874322/prevaccination-epidemiology-of-herpes-zoster-in-denmark-quantification-of-occurrence-and-risk-factors
#5
Sigrun A J Schmidt, Mogens Vestergaard, Lisbeth M Baggesen, Lars Pedersen, Henrik C Schønheyder, Henrik T Sørensen
BACKGROUND: Herpes zoster (HZ) is a vaccine-preventable disease caused by reactivation of the varicella-zoster virus. Unfortunately, formulation of recommendations on routine immunization is hampered by a lack of data on disease burden, since most countries do not record cases of HZ in the general population. We developed and validated an algorithm to identify HZ based on routinely collected registry data and used it to quantify HZ occurrence and risk factors in Denmark prior to marketing of the HZ vaccine...
September 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28855000/vaccines-for-older-adults
#6
Chad Worz, Caren McHenry Martin, Catherine Travis
Several vaccine-preventable diseases-influenza, pneumonia, herpes zoster, and pertussis-threaten the health of older adults in the United States. Both the costs associated with treating these diseases and the potential to increase morbidity and mortality are high for this patient population. Pharmacists and other health care professionals play a significant role in ensuring the elderly patient receives the recommended vaccines at the recommended intervals.
September 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28853238/herpes-zoster-as-a-risk-factor-for-incident-giant-cell-arteritis
#7
Bryant R England, Ted R Mikuls, Fenglong Xie, Shuo Yang, Lang Chen, Jeffrey R Curtis
OBJECTIVES: Histopathological studies have implicated herpes zoster (HZ) as a causative organism of giant cell arteritis (GCA). We assessed the epidemiologic association of HZ events with incident GCA. METHODS: We performed a retrospective cohort study utilizing two, large, independent US administrative datasets (Medicare 5% and Truven MarketScan) with eligible subjects having 12 months of continuous coverage, >50 years old, and without history of GCA or polymyalgia rheumatica...
August 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28845577/the-safety-and-immunogenicity-of-live-zoster-vaccination-in-patients-with-rheumatoid-arthritis-before-starting-tofacitinib-a-randomized-phase-ii-trial
#8
Kevin L Winthrop, Ann G Wouters, Ernest H Choy, Koshika Soma, Jennifer A Hodge, Chudy I Nduaka, Pinaki Biswas, Elie Needle, Sherry Passador, Christopher F Mojcik, William F Rigby
OBJECTIVE: Patients with rheumatoid arthritis (RA) are at increased risk of herpes zoster, and vaccination is recommended for patients ages 50 years and older, prior to starting treatment with biologic agents or tofacitinib. Tofacitinib is an oral JAK inhibitor for the treatment of RA. We evaluated its effect on the immune response and safety of live zoster vaccine (LZV). METHODS: In this phase II, 14-week, placebo-controlled trial, patients ages 50 years and older who had active RA and were receiving background methotrexate were given LZV and randomized to receive tofacitinib 5 mg twice daily or placebo 2-3 weeks postvaccination...
August 28, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28838148/serum-c-reactive-protein-and-congestive-heart-failure-as-significant-predictors-of-herpes-zoster-vaccine-response-in-elderly-nursing-home-residents
#9
Chris P Verschoor, Alina Lelic, Robin Parsons, Carole Evelegh, Jonathan L Bramson, Jennie Johnstone, Mark B Loeb, Dawn M E Bowdish
Background: Elderly long-term care residents often exhibit a myriad of risk factors for immune dysfunction, including chronic inflammation and multiple comorbid conditions, which undoubtedly contribute to their enhanced susceptibility to infection. Hence, understanding the factors required for optimal vaccine responsiveness is critical. Methods: We examined 187 elderly nursing home residents (aged 80-102 years) and 50 community-dwelling seniors (aged 60-75 years) immunized with the live-attenuated varicella-zoster virus (VZV) vaccine...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28837183/keratitis-in-association-with-herpes-zoster-and-varicella-vaccines
#10
A P Grillo, F W Fraunfelder
The objective of this review was to collect reports of keratitis in association with herpes zoster virus (HZV) or varicella zoster virus (VZV) vaccines. HZV vaccination is intended for at-risk adult populations and VZV vaccination is intended for all pediatric patients. We reviewed the literature and reports of keratitis in association with herpes zoster or varicella vaccine from the National Registry of Drug-Induced Ocular Side Effects and the World Health Organization. Twenty-four cases of unilateral keratitis in association with VZV vaccines were collected from the adverse reaction databases and literature...
July 2017: Drugs of Today
https://www.readbyqxmd.com/read/28836951/hospitalizations-realted-to-herpes-zoster-infection-in-the-canary-islands-spain-2005-2014
#11
Amós García-Rojas, Ruth Gil-Prieto, Domingo Ángel Núñez-Gallo, Petra Matute-Cruz, Angel Gil-de-Miguel
BACKGROUND: Herpes zoster is an important problem of public health especially among the elderly in Spain. METHODS: A population-based retrospective epidemiological study to estimate the burden of herpes zoster requiring hospitalization in the Canary Islands, Spain was conducted by using data from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos. Records of all patients admitted to hospital with a diagnosis of herpes zoster in any position and cases of primary diagnosis (ICD-9-MC codes 053...
August 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28833387/characterization-of-an-anti-varicella-zoster-virus-compound-that-targets-the-portal-protein-encoded-by-orf54
#12
Ruka Yasui, Chinatsu Yoshida, Toyofumi Yamaguchi, Naoki Inoue
An anti-varicella-zoster virus compound, a 5-chlorobenzo[b]thiophen derivative (45B5), was characterized. Its 50% effective concentration against the cell-free vaccine Oka strain and 50% cytotoxic concentration in human fibroblasts were 16.9 μM and more than 100 μM, respectively. Treatment with 45B5 decreased viral DNA synthesis as well as IE62 expression weakly but significantly. All 45B5-resistant viral clones isolated had at least one mutation in ORF54 that encodes the portal protein. There were no effects on the interaction of the portal protein with the scaffold protein...
August 19, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28830902/zoster-vaccine-associated-primary-varicella-infection-in-an-immunocompetent-host
#13
Kaoru Harada, Henry Heaton, Jason Chen, Marietta Vazquez, Jaimie Meyer
A 64-year-old immunocompetent man developed a widespread pruritic and vesicular rash 2 weeks after receiving the zoster vaccine (Zostavax). He had fever, bandaemia with normal total white blood cell count and mild transaminitis. PCR testing of serum and skin was positive for varicella zoster virus (VZV), while serum VZV IgG was negative. The analysis of single nucleotide polymorphism by PCR and sequencing from the skin swab was consistent with the vaccine strain. The patient received 1 week of intravenous acyclovir and was discharged after all lesions had crusted...
August 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28830693/immunogenicity-and-safety-of-zoster-vaccine-live-administered-with-quadrivalent-influenza-virus-vaccine
#14
Myron J Levin, Ulrike K Buchwald, Julie Gardner, Jason Martin, Jon E Stek, Elizabeth Brown, Zoran Popmihajlov
OBJECTIVES: Randomized, blinded, placebo-controlled trial to evaluate the safety and immunogenicity of ZOSTAVAX™ (ZV) administered concomitantly with quadrivalent inactivated influenza vaccine (IIV4) in adults≥50years of age (NCT02519855). METHODS: Overall, 440 participants were randomized into the Concomitant Group (CG) and 442 into the Sequential Group (SG). The CG received ZV and IIV4 at separate injection sites on Day 1 and matching placebo at Week 4. The SG received placebo and IIV4 (2015-2016 influenza season) at separate injection sites on Day 1 and ZV at Week 4...
August 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28807604/focusing-on-the-implementation-of-21st-century-vaccines-for-adults
#15
Paolo Bonanni, Guglielmo Bonaccorsi, Chiara Lorini, Francesca Santomauro, Emilia Tiscione, Sara Boccalini, Angela Bechini
Adult immunization is a priority for public health, particularly in countries where an aging population has become increasingly more numerous. Protection against diseases which typically affect adults (like flu, pneumococcal diseases and Herpes zoster), the shift of age of infections which originally affected children (like measles), the decreasing protection with time for infections which need periodical booster doses of vaccines (Tdap), the availability of vaccines which can also impact on adult health (HPV) are only some examples of the importance of implementing targeted vaccination strategies...
August 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28805309/safety-of-herpes-zoster-vaccination-among-inflammatory-bowel-disease-patients-being-treated-with-anti-tnf-medications
#16
N Khan, Y Shah, C Trivedi, J D Lewis
BACKGROUND: The risk of herpes zoster (HZ) is elevated in inflammatory bowel disease (IBD) patients treated with anti-TNF medications. While it is optimal to give herpes zoster vaccine prior to initiation of therapy clinical circumstances may not always allow this. AIM: To determine the safety of giving herpes zoster vaccine while patients are on anti-TNF therapy. METHODS: We conducted a retrospective cohort study involving IBD patients who were followed in the Veterans Affairs (VA) healthcare system between 2001 and 2016...
August 14, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28804114/clinical-epidemiological-and-etiological-studies-of-adult-aseptic-meningitis-report-of-11-cases-with-varicella-zoster-virus-meningitis
#17
Shinichi Takeshima, Yuji Shiga, Takahiro Himeno, Keisuke Tachiyama, Teppei Kamimura, Ryuhei Kono, Makoto Takemaru, Jun Takeshita, Yutaka Shimoe, Masaru Kuriyama
We treated 11 cases (52.7 ± 14.9 years, all male) with varicella zoster virus (VZV) meningitis and 437 cases with adult aseptic meningitis from 2004 to 2016. The incidence rate of adult VZV meningitis in the cases with aseptic meningitis was 2.5%. Herpes zoster infections are reported to have occurred frequently in summer and autumn. VZV meningitis also occurred frequently in the similar seasons, in our patients. The diagnoses were confirmed in 9 cases with positive VZV-DNA in the cerebrospinal fluid and in 2 cases with high VZV-IgG indexes (> 2...
August 11, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28751095/a-comprehensive-review-of-immunization-practices-in-solid-organ-transplant-and-hematopoietic-stem-cell-transplant-recipients
#18
REVIEW
Pearlie P Chong, Robin K Avery
BACKGROUND: Vaccine-preventable diseases, especially influenza, varicella, herpes zoster, and invasive pneumococcal infections, continue to lead to significant morbidity and mortality in solid organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients. METHODS: We highlight guideline recommendations for the use of key vaccines in SOT and HSCT recipients and to review the latest evidence and developments in the field. RESULTS: Physicians should vaccinate individuals with end-stage organ disease, as vaccine seroresponse rates are higher pretransplantation...
July 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28748773/differentiation-between-wild-type-and-vaccines-strains-of-varicella-zoster-virus-vzv-based-on-four-single-nucleotide-polymorphisms
#19
L Jin, S Xu, P A C Maple, W Xu, K E Brown
Varicella-zoster virus (VZV) infection (chickenpox) results in latency and subsequent reactivation manifests as shingles. Effective attenuated vaccines (vOka) are available for prevention of both illnesses. In this study, an amplicon-based sequencing method capable of differentiating between VZV wild-type (wt) strains and vOka vaccine is described. A total of 44 vesicular fluid specimens collected from 43 patients (16 from China and 27 from the UK) with either chickenpox or shingles were investigated, of which 10 had received previous vaccination...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28735059/too-young-to-be-vaccinated-hospitalizations-caused-by-varicella-among-children-in-the-first-year-of-life
#20
Ewelina Gowin, Jacek Wysocki, Michał Michalak, Danuta Januszkiewicz-Lewandowska
AIM: The aim of this study was to analyse the causes of hospitalization in the course of varicella in children during the first year of life. METHODS: An analysis was performed of the medical documentation of 359 children hospitalized for varicella on the infectious diseases ward at the Children's Hospital in Poznan (Poland) between January 2007 and August 2015. RESULTS: Of the 359 children in the study group, 96 were younger than 1 year old...
July 19, 2017: International Journal of Infectious Diseases: IJID
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