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https://www.readbyqxmd.com/read/29139368/herpes-zoster-immunosuppression-and-vaccination-far-from-a-blistering-pace
#1
Warren R Heymann
No abstract text is available yet for this article.
2017: Skinmed
https://www.readbyqxmd.com/read/29137604/varicella-zoster-virus-associated-morbidity-and-mortality-in-africa-a-systematic-review
#2
Hannah Hussey, Leila Abdullahi, Jamie Collins, Rudzani Muloiwa, Gregory Hussey, Benjamin Kagina
BACKGROUND: Varicella zoster virus (VZV) causes varicella and herpes zoster. These vaccine preventable diseases are common globally. Most available data on VZV epidemiology are from industrialised temperate countries and cannot be used to guide decisions on the immunization policy against VZV in Africa. This systematic review aims to review the published data on VZV morbidity and mortality in Africa. METHODS: All published studies conducted in Africa from 1974 to 2015 were eligible...
November 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29129213/vaccinations-in-older-adults
#3
REVIEW
Megan Burke, Theresa Rowe
Vaccines are important for preventing infections in adults aged ≥65 years. Older adults are at increased risk for complications from vaccine-preventable illnesses due to age-associated changes in immune function and chronic medical comorbidities. Vaccination rates for older adults remain low despite widely accepted practice guidelines. Recommended vaccinations for older adults include (1) influenza; (2) pneumococcal; (3) herpes zoster; (4) tetanus, diphtheria, pertussis; and (5) hepatitis B. Cost influences vaccination rates in older adults...
February 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29126292/safety-and-immunogenicity-of-inactivated-varicella-zoster-virus-vaccine-in-adults-with-autoimmune-disease-a-phase-2-randomized-double-blind-placebo-controlled-clinical-trial
#4
Michael Eberhardson, Stephen Hall, Kim A Papp, Tina M Sterling, Jon E Stek, Lei Pang, Yanli Zhao, Janie Parrino, Zoran Popmihajlov
Background: Immunogenicity and safety of inactivated zoster vaccine (ZVIN) were evaluated in adults with autoimmune disease. Methods: Adults with autoimmune disease treated with immunosuppressive therapy (biologic or nonbiologic) were randomized to receive 4 doses of ZVIN, ZVIN containing a higher quantity of antigen, or placebo. To measure varicella-zoster virus (VZV)-specific immune responses using glycoprotein enzyme-linked immunosorbent assay (gpELISA) and interferon-gamma enzyme-linked immunospot (IFN-γ ELISPOT), blood samples were collected at baseline, post-doses 2, 3, and 4...
October 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29118757/decreased-immunity-to-varicella-zoster-virus-in-giant-cell-arteritis
#5
Christien Rondaan, Kornelis S M van der Geest, Elisabeth Eelsing, Annemieke M H Boots, Nicolaas A Bos, Johanna Westra, Elisabeth Brouwer
Introduction: Herpes zoster, which can have a major impact on quality of life, results from reactivation of a latent varicella zoster virus (VZV) infection. We hypothesized that giant cell arteritis (GCA) patients are at increased risk of herpes zoster because of treatment with high-dose glucocorticoids and advanced age. Aim of the study, therefore, was to determine cell-mediated and humoral immunity to VZV in patients with GCA, patients with closely related disease polymyalgia rheumatica (PMR; treated with lower doses of glucocorticoids) and healthy controls (HCs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29092706/rates-of-hospitalisation-for-herpes-zoster-may-warrant-vaccinating-indigenous-australians-under-70
#6
Meru Sheel, Frank H Beard, Aditi Dey, Kristine Macartney, Peter B McIntyre
No abstract text is available yet for this article.
November 6, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29081071/herpes-zoster-meningitis-in-immunocompetent-children-two-case-reports-and-a-literature-review
#7
Naohiro Itoh, Kouji Motokura, Akira Kumakura, Daisuke Hata, Atsuko Hata
We encountered two cases of Herpes zoster (HZ) meningitis, a rarely occurring complication of HZ, in previously healthy children. One patient treated with i.v. acyclovir (ACV, 31 mg/kg/day) did not recover. His symptoms were relieved somewhat by increased ACV dosage, but it caused transient renal dysfunction. Another patient treated with i.v. ACV (30 mg/kg/day) recovered. Treatment for HZ meningitis in immunocompetent children has not been established. In a literature review, 80% of 20 patients were treated with the usual dose of ACV 15-30 mg/kg/day...
October 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29079160/herpes-zoster-in-the-older-adult
#8
REVIEW
Amrita R John, David H Canaday
Herpes zoster (HZ) is the result of reactivation of latent varicella zoster virus (VZV) and occurs most frequently in older adults. Classically, HZ presents as a unilateral, selflimited, dermatomal rash. Postherpetic neuralgia (PHN) is a common sequela, presenting as severe pain that persists after the rash has resolved. In the elderly, PHN can be debilitating and requires a prompt diagnosis, treatment with antivirals, and adequate pain control. A longer-term pain management strategy is required if PHN occurs...
December 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29079101/a-randomized-lot-to-lot-immunogenicity-consistency-study-of-the-candidate-zoster-vaccine-hz-su
#9
Ana Strezova, Olivier Godeaux, Naresh Aggarwal, Geert Leroux-Roels, Marta Lopez-Fauqued, Pierre Van Damme, Carline Vanden Abeele, Ilse Vastiau, Thomas C Heineman, Himal Lal
BACKGROUND: The risk of developing herpes zoster (HZ) increases with age and is thought to be associated with a decrease in cell-mediated immunity in older adults. The adjuvanted varicella-zoster virus (VZV) glycoprotein E (gE) recombinant subunit vaccine (HZ/su) showed >90% efficacy in the prevention of HZ when administered in adults ≥50 years of age. Here we aim to evaluate immunogenicity consistency of 3 different HZ/su vaccine lots and to assess safety of these lots. METHODS: This multicenter, phase III, double-blind, randomized study (NCT02075515), assessed lot-to-lot consistency in terms of immunogenicity of HZ/su and also assessed safety of these lots...
October 24, 2017: Vaccine
https://www.readbyqxmd.com/read/29076688/herpes-zoster-during-immunosuppressive-therapy-for-autoimmune-diseases
#10
Mohammad Faizan Zahid, Mariam Ghufran, Armaghan-E-Rehman Mansoor, Muhammad Rizwan Sohail
BACKGROUND: Patients on immunosuppressive therapy are at a greater risk for herpes zoster reactivation and are more likely to have adverse outcomes. Propylactic antivrials and vaccinations may potentially prevent these complications. METHODS: Medical literature addressing the clinical course and therapy of herpes zoster in patients receiving immunosuppressive therapy for autoimmune disorders, and the roles of anti-viral prophylaxis and vaccination was reviewed. Research databases including PubMed, Ovid, Medline, Google Scholar and Cochrane were utilized...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29076102/epidemiological-profile-of-acute-viral-encephalitis
#11
Rajesh Kumar, Pankaj Kumar, Manoj Kumar Singh, Dipti Agarwal, Bendangienla Jamir, Shashi Khare, Samrendra Narayan
OBJECTIVE: To study the etiology and clinico-epidemiological profile of acute viral encephalitis in children with acute encephalitis syndrome (AES). METHODS: An observational study including 100 patients fulfilling the criteria for AES was conducted in children of age group 1 mo - 16 y. Viral isolation was done on RD cells, HEp-2 cells and Vero cells from the cerebrospinal fluid samples of suspected viral encephalitis (VE) cases. An enzyme immunoassay for IgM antibodies was performed for measles, mumps, Varicella zoster virus (VZV), Herpes simplex virus 1 (HSV1) and Japanese encephalitis virus (JEV)...
October 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29075289/serology-of-viral-infections-and-tuberculosis-screening-in-an-ibd-population-referred-to-a-tertiary-centre-of-southern-italy
#12
Marco Ardesia, Giuseppe Costantino, Placido Mondello, Angela Alibrandi, Walter Fries
BACKGROUND: With the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. Prevalence of the most important infectious agents may vary in different geographical areas. The aim of our study was to assess the immune status for hepatitis B, varicella, mononucleosis, and cytomegalovirus infection together with the determination of the hepatitis C and tuberculosis status in Southern Italy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29053937/studies-with-herpes-zoster-vaccines-in-immune-compromised-patients
#13
Myron J Levin, Eddy Bresnitz, Zoran Popmihajlov, Adriana Weinberg, Kai-Li Liaw, English Willis, Jeffrey R Curtis
The active component of the herpes zoster vaccine (ZVL), licensed for people ≥50 years of age, is a live attenuated varicella-zoster virus. ZVL is contraindicated for immune compromised individuals, with limited regard to the degree of immunosuppression. Areas covered: This review evaluates phase I and II and observational studies for ZVL, and published reports of the off-label use of ZVL, for conditions and therapies for which investigators considered the risk-benefit for using ZVL to be favorable. It also discusses exploratory trials of ZVL for additional immune compromising conditions, and summarizes clinical guidelines from many countries and professional societies that are based upon recent investigations...
November 7, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29050801/projections-of-zoster-incidence-in-australia-based-on-demographic-and-transmission-models-of-varicella-zoster-virus-infection
#14
Valentina Costantino, Heather F Gidding, James G Wood
Re-exposure to varicella infection is believed to delay the occurrence of herpes zoster (HZ), which has led to predictions of increased HZ following introduction of varicella vaccination programs. However, there is evidence of rising HZ rates before vaccination was introduced. Here, we explore a potential explanation for this effect through demographic change leading to reductions in varicella exposure and boosting in the context of Australia over the 20th century. To study this hypothesis, we integrated observed changes in Australian birth and age-specific death rates with a varicella transmission model...
October 16, 2017: Vaccine
https://www.readbyqxmd.com/read/29047317/varicella-and-herpes-zoster-vaccine-development-lessons-learned
#15
Charlotte Warren-Gash, Harriet Forbes, Judith Breuer
Before vaccination, varicella zoster virus (VZV), which is endemic worldwide, led to almost universal infection. This neurotropic virus persists lifelong by establishing latency in sensory ganglia, where its reactivation is controlled by VZV-specific T-cell immunity. Lifetime risk of VZV reactivation (zoster) is around 30%. Vaccine development was galvanised by the economic and societal burden of VZV, including debilitating zoster complications that largely affect older individuals. Areas covered: We describe the story of development, licensing and implementation of live attenuated vaccines against varicella and zoster...
October 30, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29046461/human-embryonic-stem-cell-derived-neurons-are-highly-permissive-for-varicella-zoster-virus-lytic-infection
#16
Tomohiko Sadaoka, Cindi L Schwartz, Labchan Rajbhandari, Arun Venkatesan, Jeffrey I Cohen
Varicella-zoster virus (VZV) is highly cell-associated when grown in culture and has a much higher (4,000 to 20,000-fold increased) particle-to-plaque forming unit (PFU) ratio in vitro than herpes simplex virus (HSV). In contrast, VZV is highly infectious in vivo by airborne transmission. Neurons are major targets for VZV in vivo, in which the virus can establish latency and reactivate to produce infectious virus. Using neurons derived from human embryonic stem cells (hESC) and cell-free wild-type (WT) VZV, we demonstrate that neurons are nearly 100 times more permissive for WT VZV infection than very early passage human embryonic lung cells or MRC-5 diploid human fibroblasts, the cells used for vaccine production or virus isolation...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#17
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29032243/dna-methylation-patterns-are-related-to-co-morbidity-status-and-circulating-c-reactive-protein-levels-in-the-nursing-home-elderly
#18
Chris P Verschoor, Lisa M McEwen, Michael S Kobor, Mark B Loeb, Dawn M E Bowdish
Elderly residents of long-term care commonly exhibit a number of age-related health deficits, including impaired physical and cognitive function, chronic illnesses, and chronic inflammation. Given our previous data relating the phenotype and function of innate and adaptive leukocytes from the nursing home elderly to chronic conditions and inflammatory biomarkers, we hypothesized that these factors would influence the regulatory programming of immune cells, thereby contributing to immune dysfunction. Since DNA methylation represents both an important regulatory mechanism of cells as well as a biomarker of health and disease, we sought to characterize the methylome of peripheral blood mononuclear cells (PBMCs) from the nursing home elderly (n=23; 82-98years old, 70% female), and compare these patterns to pathological factors such as dementia, co-morbidity score and frailty, and immune-related factors such as serum C-reactive protein (CRP) and cytokine levels and varicella-zoster virus (VZV) vaccine responsiveness...
October 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29029303/clinical-usage-of-the-candidate-adjuvanted-hz-su-zoster-vaccine-re-vaccination-of-recipients-of-live-attenuated-zoster-vaccine-and-co-administration-with-a-seasonal-influenza-vaccine
#19
Michael N Oxman, Ruth Harbecke, David M Koelle
No abstract text is available yet for this article.
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029224/immunogenicity-and-safety-of-an-adjuvanted-herpes-zoster-subunit-vaccine-co-administered-with-seasonal-influenza-vaccine-in-adults-aged-50-years-and-older
#20
Tino F Schwarz, Naresh Aggarwal, Beate Moeckesch, Isabelle Schenkenberger, Carine Claeys, Martine Douha, Olivier Godeaux, Katrijn Grupping, Thomas C Heineman, Marta Lopez Fauqued, Lidia Oostvogels, Peter Van den Steen, Himal Lal
Background: The immunogenicity and safety of an adjuvanted herpes zoster subunit vaccine (HZ/su) when co-administered with a quadrivalent seasonal inactivated influenza vaccine (IIV4) was investigated in a phase 3, open-label, randomized clinical trial in adults aged ≥50 years. Methods: Subjects were randomized 1:1 to receive either HZ/su (VZV glycoprotein E [gE]; AS01B Adjuvant System) and IIV4 at day 0 followed by a second HZ/su dose at month 2 (Co-ad group), or IIV4 at month 0 and HZ/su at months 2 and 4 (Control group)...
September 26, 2017: Journal of Infectious Diseases
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