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https://www.readbyqxmd.com/read/27902409/prevention-of-herpes-zoster-and-its-complications-from-the-clinic-to-the-real-life-experience-with-the-vaccine
#1
Giovanni Gabutti, Nicoletta Valente, Parvanè Kuhdari, Silvia Lupi, Armando Stefanati
The Herpes Zoster (HZ) is an acute viral illness characterized by a vesicular rash, with unilateral distribution, which can eventually cause severe complications, such as the post-herpetic neuralgia (PHN), the ophthalmic zoster, stroke or other neurological complications. In Europe, an incidence between 2.0 and 4.6 cases per 1,000 persons-year is estimated, with an increase after 50 years of age. Currently, the therapeutic options for HZ are only partially effective to limit the acute phase, while the management of complications is frequently complex and not satisfactory...
November 4, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27890168/incidence-and-prevention-of-herpes-zoster-reactivation-in-patients-with-autoimmune-diseases
#2
REVIEW
Eliza F Chakravarty
Herpes zoster is the reactivation of latent varicella zoster virus usually occurring decades after initial exposure, and manifesting as a painful vesicular rash occurring along one or more dermatomes. Zoster incidence increases with age as cell mediated immunity against latent virus wanes. Epidemiological evidence suggests that individuals with underlying rheumatic diseases are at increased risk for zoster. It remains unclear whether this is due to immunosuppressive medications or from immune dysregulation of the underlying disease...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27876197/vaccination-of-special-populations-protecting-the-vulnerable
#3
REVIEW
Mark Doherty, Ruprecht Schmidt-Ott, Jose Ignacio Santos, Lawrence R Stanberry, Annika M Hofstetter, Susan L Rosenthal, Anthony L Cunningham
One of the strategic objectives of the 2011-2020 Global Vaccine Action Plan is for the benefits of immunisation to be equitably extended to all people. This approach encompasses special groups at increased risk of vaccine-preventable diseases, such as preterm infants and pregnant women, as well as those with chronic and immune-compromising medical conditions or at increased risk of disease due to immunosenescence. Despite demonstrations of effectiveness and safety, vaccine uptake in these special groups is frequently lower than expected, even in developed countries with vaccination strategies in place...
November 18, 2016: Vaccine
https://www.readbyqxmd.com/read/27862309/study-of-greek-children-and-youths-with-cystic-fibrosis-identifies-immunisation-gaps-and-delays
#4
Helena C Maltezou, Stavros Doudounakis, Maria Lekaditi, Kalliopi Tanou, Panos Katerelos, Maria Theodoridou
AIM: Data about immunisation rates in cystic fibrosis (CF) patients are scarce. We estimated the rates and timeliness of immunisations in CF patients aged 0.55-22 years. METHODS: We studied 122 subjects at a hospital in Greece in 2014. A standard questionnaire was used to collect data and parents' opinions about immunisations. RESULTS: The complete immunisation rates were 92.6% for diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis-Haemophilus influenzae (DTaP-IPV-Hib), 96...
November 10, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27857091/intradermal-zoster-vaccines-good-for-the-old-and-the-young
#5
(no author information available yet)
This 'dose-sparing, and thus cost-sparing, intradermal vaccine' may not only reduce the burden of illness in the elderly population, but also chickenpox in children.
November 18, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27835757/vaccine-strain-herpes-zoster-found-in-the-trigeminal-nerve-area-in-a-healthy-child-a-case-report
#6
Sayaka Iwasaki, Kouji Motokura, Yoshitaka Honda, Masamitsu Mikami, Daisuke Hata, Atsuko Hata
A previously healthy 2-year-old girl, vaccinated for varicella at 17 months, was admitted because of left-sided facial herpes zoster caused by vaccine-strain varicella-zoster virus (VZV). She recovered fully with no complication after intravenous treatment using acyclovir. Earlier reports have described that herpes zoster (HZ) rashes caused by vaccine-strain VZV tend to occur on the dermis corresponding to the skin area where the varicella vaccine was received. However, rashes appeared on this girl only in the trigeminal nerve area, which is unrelated to the vaccinated site...
November 3, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27834395/cns-infections-a-new-herpes-zoster-subunit-vaccine-for-older-adults
#7
Charlotte Warren-Gash, Judith Breuer
No abstract text is available yet for this article.
November 11, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27807590/mitochondrial-haplogroups-as-a-risk-factor-for-herpes-zoster
#8
Rebecca T Levinson, Todd Hulgan, Spyros A Kalams, Joshua P Fessel, David C Samuels
Background.  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine mitochondrial haplogroups as a potential host factor related to herpes zoster incidence. Methods.  Study participants were drawn from BioVU, a deoxyribonucleic acid (DNA) biobank connected to deidentified electronic medical records (EMRs) from Vanderbilt University Medical Center...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27797989/evaluation-of-the-acceptability-of-a-vaccine-against-herpes-zoster-in-the-over-50%C3%A2-years-old-an-italian-observational-study
#9
Nicoletta Valente, Silvia Lupi, Armando Stefanati, Marisa Cova, Najada Sulcaj, Lucia Piccinni, Giovanni Gabutti
OBJECTIVE: The aim of the study was to evaluate awareness of the varicella zoster virus and the acceptability of the newly available herpes zoster (HZ) vaccine in the over 50 years old general population. DESIGN: The research was observational. SETTING: The study was carried out in Ferrara by administering a questionnaire to patients of the Local Health Authority (LHA), general practitioners (GPs) and Public Health Department outpatient clinics...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27795427/the-glycoprotein-b-cytoplasmic-domain-lysine-cluster-is-critical-for-varicella-zoster-virus-cell-cell-fusion-regulation-and-infection
#10
Edward Yang, Ann M Arvin, Stefan L Oliver
: The conserved glycoproteins gB and gH-gL are essential for herpesvirus entry and cell-cell fusion induced syncytia formation, a characteristic of Varicella Zoster Virus (VZV) pathology in skin and sensory ganglion. VZV syncytia formation, which has been implicated in the painful condition of postherpetic neuralgia, is regulated by the cytoplasmic domains of gB (gBcyt) via an immunoreceptor tyrosine-based inhibition motif (ITIM) and gH (gHcyt). A lysine cluster (K894, K897, K898, and K900) in the VZV gBcyt was identified by sequence alignment to be conserved among alphaherpesviruses suggesting a functional role...
October 26, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27795423/dysregulated-glycoprotein-b-mediated-cell-cell-fusion-disrupts-varicella-zoster-virus-and-host-gene-transcription-during-infection
#11
Stefan L Oliver, Edward Yang, Ann M Arvin
: The highly conserved herpesvirus glycoprotein complex, gB/gH-gL, mediates membrane fusion during virion entry and cell-cell fusion. Varicella-zoster virus (VZV) characteristically forms multi-nucleated cells, or syncytia, during the infection of human tissues but little is known about this process. The cytoplasmic domain of VZV gB (gBcyt) has been implicated in cell-cell fusion regulation because a gB[Y881F] substitution causes hyperfusion. The gBcyt regulation is necessary for VZV pathogenesis as the hyperfusogenic mutant gB[Y881F] is severely attenuated in human skin xenografts...
October 26, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27786611/herpes-zoster-vaccine-zostavax%C3%A2-cellulitic-injection-site-reaction-or-bacterial-cellulitis
#12
Ian F Cook
A 70 year old woman presented with a cellulitic reaction following Zostavax® injection. This reaction could be differentiated from bacterial cellulitis on the basis of the temporal relationship between vaccination and onset of the reaction, its non progression and unresponsiveness to antibiotic therapy. Alerting health care providers to this type of reaction, also seen with pneumococcal and pertussis containing vaccines, should avoid the inappropriate use of antibiotics.
October 27, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27780480/measles-mumps-rubella-and-vzv-importance-of-serological-testing-of-vaccine-preventable-diseases-in-young-adults-living-with-hiv-in-germany
#13
C Schwarze-Zander, R Draenert, C Lehmann, M Stecher, C Boesecke, S Sammet, J C Wasmuth, U Seybold, D Gillor, U Wieland, T Kümmerle, C P Strassburg, A Mankertz, A M Eis-Hübinger, G Jäger, G Fätkenheuer, J R Bogner, J K Rockstroh, J J Vehreschild
Measles, mumps, rubella (MMR) and varicella zoster virus (VZV) infection can cause serious diseases and complications in the HIV-positive population. Due to successful vaccination programmes measles, mumps and congenital rubella syndrome has become neglected in Germany. However, recent outbreaks of measles have occurred from import-associated cases. In this cross-sectional study the serostatus for MMR and VZV in 2013 HIV-positive adults from three different university outpatient clinics in Bonn (n = 544), Cologne (n = 995) and Munich (n = 474) was analysed...
October 26, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27765026/increasing-incidence-associated-with-herpes-zoster-infection-in-british-columbia-canada
#14
Fawziah Marra, Mei Chong, Mehdi Najafzadeh
BACKGROUND: Recent studies have shown an increasing incidence of herpes zoster (HZ) infection, which may be related to the introduction of varicella vaccination programs in children. We examined the epidemiology and treatment costs of HZ and post-herpetic neuralgia (PHN) over time in British Columbia, Canada. METHODS: The cohort consisted of all cases with HZ infection from January 1, 1997 and December 31, 2012. Incident zoster was defined as a case (ICD-9 053 or ICD-10 B02) without a previous episode of HZ or PHN in the previous 12 months...
October 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27764254/defective-t-memory-cell-differentiation-after-varicella-zoster-vaccination-in-older-individuals
#15
Qian Qi, Mary M Cavanagh, Sabine Le Saux, Lisa E Wagar, Sally Mackey, Jinyu Hu, Holden Maecker, Gary E Swan, Mark M Davis, Cornelia L Dekker, Lu Tian, Cornelia M Weyand, Jörg J Goronzy
Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27753768/varicella-vaccination-of-children-with-leukemia-without-interruption-of-maintenance-therapy-a-danish-experience
#16
Lotte Møller Smedegaard, Anja Poulsen, Ines Ackerl Kristensen, Susanne Rosthøj, Kjeld Schmiegelow, Ulrikka Nygaard
BACKGROUND: Varicella-zoster virus (VZV) can be fatal or cause severe complications in children with acute lymphoblastic leukemia (ALL). This analysis set out to investigate the morbidity and mortality of VZV vaccination without interruption of maintenance therapy in children with ALL. METHODS: Files of 73 seronegative children with ALL were examined for data regarding VZV vaccination and infection, and long-term seroconversion was measured. Criteria before VZV vaccination were (1) seronegative, (2) in complete remission, (3) age ≥ 1...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27743284/determining-the-optimal-vaccination-schedule-for-herpes-zoster-a-cost-effectiveness-analysis
#17
Phuc Le, Michael B Rothberg
BACKGROUND: The Advisory Committee on Immunization Practices recommends a single dose of herpes zoster (HZ) vaccine in persons aged 60 years or older, but the efficacy decreases to zero after approximately 10 years. A booster dose administered after 10 years might extend protection, but the cost-effectiveness of a booster strategy has not been examined. OBJECTIVE: We aimed to determine the optimal schedule for HZ vaccine DESIGN: We built a Markov model to follow patients over their lifetime...
October 14, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27741018/prevalence-of-ocular-manifestations-and-visual-outcomes-in-patients-with-herpes-zoster-ophthalmicus
#18
Simon K H Szeto, Tommy C Y Chan, Raymond L M Wong, Alex L K Ng, Emmy Y M Li, Vishal Jhanji
PURPOSE: To investigate the prevalence of ocular manifestations and visual outcomes in patients with herpes zoster ophthalmicus (HZO). METHODS: Consecutive cases diagnosed with HZO who attended 2 hospitals between July 1, 2011, and June 30, 2015, were retrospectively reviewed. Patient demographics, clinical presentations, and management were reviewed. The logistic regression model was used to estimate the odds ratio of visual loss with ocular manifestations. RESULTS: A total of 259 patients were included...
October 12, 2016: Cornea
https://www.readbyqxmd.com/read/27730484/herpes-zoster-vaccine-time-for-a-boost
#19
Krishna P Reddy
No abstract text is available yet for this article.
October 11, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27720342/national-and-state-specific-shingles-vaccination-among-adults-aged-%C3%A2-60-years
#20
Peng-Jun Lu, Alissa O'Halloran, Walter W Williams, Rafael Harpaz
INTRODUCTION: Shingles (herpes zoster) causes substantial morbidity, especially among older adults. The shingles vaccine has been recommended for people aged ≥60 years since 2006. This study assessed recent shingles vaccination at national and state levels among adults aged ≥60 years. METHODS: The 2014 Behavioral Risk Factor Surveillance System data were analyzed in 2015 to assess shingles vaccination coverage among adults aged ≥60 years at national and state levels...
October 5, 2016: American Journal of Preventive Medicine
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