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https://www.readbyqxmd.com/read/28636704/trends-in-nationwide-herpes-zoster-emergency-department-utilization-from-2006-to-2013
#1
Erica D Dommasch, Cara J Joyce, Arash Mostaghimi
Importance: The effect of vaccination on emergency department (ED) utilization for herpes zoster (HZ) has not been examined to date. Objective: To determine trends in US ED utilization and costs associated with HZ. Design, Setting, and Participants: The Nationwide Emergency Department Sample data set was examined for temporal trends in the number of visits and costs for treatment of HZ in EDs in the United States from January 1, 2006, through December 31, 2013...
June 21, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28633742/cutaneous-varicella-zoster-virus-infection-following-zoster-vaccination-report-of-post-vaccination-herpes-zoster-skin-infection-and-literature-review-of-zoster-vaccination-efficacy-and-guidelines
#2
Katherine M Stiff, Philip R Cohen
BackgroundHerpes zoster vaccine is currently recommended in the United States for immune competent individuals ≥60 years. The efficacy of the herpes zoster vaccine decreases with age and with time following vaccination.PurposeAn elderly man with herpes zoster following vaccination is described. The guidelines for vaccination and issues regarding re-vaccination are reviewed. METHODS: PubMed was used to search the following terms: efficacy, elderly, herpes zoster, herpes zoster incidence, herpes zoster recurrence, and vaccination...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28629665/efficacy-and-safety-of-tofacitinib-monotherapy-tofacitinib-with-methotrexate-and-adalimumab-with-methotrexate-in-patients-with-rheumatoid-arthritis-oral-strategy-a-phase-3b-4-double-blind-head-to-head-randomised-controlled-trial
#3
Roy Fleischmann, Eduardo Mysler, Stephen Hall, Alan J Kivitz, Robert J Moots, Zhen Luo, Ryan DeMasi, Koshika Soma, Richard Zhang, Liza Takiya, Svitlana Tatulych, Christopher Mojcik, Sriram Krishnaswami, Sujatha Menon, Josef S Smolen
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. The Oral Rheumatoid Arthritis triaL (ORAL) Strategy aimed to assess the comparative efficacy of tofacitinib monotherapy, tofacitinib plus methotrexate, and adalimumab plus methotrexate for the treatment of rheumatoid arthritis in patients with a previous inadequate response to methotrexate. METHODS: ORAL Strategy was a 1 year, double-blind, phase 3b/4, head-to-head, non-inferiority, randomised controlled trial in patients aged 18 years or older with active rheumatoid arthritis despite methotrexate therapy...
June 15, 2017: Lancet
https://www.readbyqxmd.com/read/28613146/revisiting-the-genotyping-scheme-for-varicella-zoster-viruses-based-on-whole-genome-comparisons
#4
Nancy J Jensen, Pierre Rivailler, Hung Fu Tseng, Mark L Quinlivan, Kay Radford, Jennifer Folster, Rafael Harpaz, Philip LaRussa, Steven Jacobsen, D Scott Schmid
We report whole-genome sequences (WGSs) for four varicella-zoster virus (VZV) samples from a shingles study conducted by Kaiser Permanente of Southern California. Comparative genomics and phylogenetic analysis of all published VZV WGSs revealed that strain KY037798 is in clade IX, which shall henceforth be designated clade 9. Previously published single nucleotide polymorphisms (SNP)-based genotyping schemes fail to discriminate between clades 6 and VIII and employ positions that are not clade-specific. We provide an updated list of clade-specific positions that supersedes the list determined at the 2008 VZV nomenclature meeting...
June 14, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28608255/temporal-trends-in-herpes-zoster-related-hospitalizations-in-italy-2001-2013-differences-between-regions-that-have-or-have-not-implemented-varicella-vaccination
#5
Nicoletta Valente, Silvia Cocchio, Armando Stefanati, Tatjana Baldovin, Domenico Martinelli, Rosa Prato, Vincenzo Baldo, Giovanni Gabutti
BACKGROUND: Herpes zoster (HZ) has a relevant impact on the population in terms of incidence and complications. AIMS: The aim of this study was to estimate the HZ-related hospitalization rates in Italy in the period 2001-2013, and to evaluate the trend of hospitalizations in the course of time pointing out any differences between regions that have or have not introduced universal childhood varicella immunization (UVI). METHODS: A retrospective analysis was conducted on hospital discharge records contained in the national database of the Ministry of Health for the period January 2001-December 2013...
June 12, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28607114/varicella-zoster-virus-specific-cellular-immune-responses-to-the-live-attenuated-zoster-vaccine-in-young-and-older-adults
#6
Adriana Weinberg, Jennifer Canniff, Nadine Rouphael, Aneesh Mehta, Mark Mulligan, Jennifer A Whitaker, Myron J Levin
The incidence and severity of herpes zoster (HZ) increases with age. The live attenuated zoster vaccine generates immune responses similar to HZ. We compared the immune responses to zoster vaccine in young and older to adults to increase our understanding of the immune characteristics that may contribute to the increased susceptibility to HZ in older adults. Young (25-40 y; n = 25) and older (60-80 y; n = 33) adults had similar magnitude memory responses to varicella-zoster virus (VZV) ex vivo restimulation measured by responder cell-frequency and flow cytometry, but the responses were delayed in older compared with young adults...
June 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28605285/analysis-of-real-world-health-care-costs-among-immunocompetent-patients-aged-50%C3%A2-years-or-older-with-herpes-zoster-in-the-united-states
#7
Juliana L Meyers, Shweta Madhwani, Debora Rausch, Sean D Candrilli, Girishanthy Krishnarajah, Songkai Yan
Few peer-reviewed publications present real-world United States (US) data describing resource utilization and costs associated with herpes zoster (HZ) and postherpetic neuralgia (PHN). The primary objective of this analysis (GSK study identifier: HO-14-14270) was to assess direct costs associated with HZ and PHN in the US using a retrospective managed care insurance claims database. Patients ≥ 50 y at HZ diagnosis were selected. Patients were excluded if they were immunocompromised before diagnosis or received an HZ vaccine at any time...
June 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28592229/the-intention-of-dutch-general-practitioners-to-offer-vaccination-against-pneumococcal-disease-herpes-zoster-and-pertussis-to-people-aged-60%C3%A2-years-and-older
#8
Birthe A Lehmann, Renske Eilers, Liesbeth Mollema, José Ferreira, Hester E de Melker
BACKGROUND: Increasing life expectancy results in a larger proportion of older people susceptible to vaccine preventable diseases (VPDs). In the Netherlands, influenza vaccination is routinely offered to people aged 60 years and older. Vaccination against pneumococcal disease, herpes zoster and pertussis is rarely used. These vaccines will be evaluated by the Dutch Health Council and might be routinely offered to older people in the near future. Possible expansion of the program depends partly on the willingness of general practitioners (GPs) to endorse additional vaccinations...
June 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28582374/management-of-corneal-scarring-secondary-to-herpes-zoster-keratitis
#9
Omar M Hassan, Asim V Farooq, Ketki Soin, Ali R Djalilian, Joshua H Hou
PURPOSE: To review the management of visually significant corneal scarring secondary to herpes zoster keratitis (HZK). METHODS: Literature review. RESULTS: Management options for visually significant corneal scarring secondary to HZK include scleral contact lenses, photorefractive or phototherapeutic keratectomy, lamellar keratoplasty, penetrating keratoplasty, and keratoprosthesis. Many authors recommend tarsorrhaphy in at-risk patients at the time of corneal transplantation...
June 2, 2017: Cornea
https://www.readbyqxmd.com/read/28550546/-protection-from-a-dormant-time-bomb-the-development-of-effective-vaccines-against-herpes-zoster
#10
REVIEW
Jörg Schelling, Ina-Maria Rückert-Eheberg, Andreas H Leischker
No abstract text is available yet for this article.
June 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28548546/the-risk-of-herpes-zoster-in-patients-with-ankylosing-spondylitis-analysis-of-the-korean-national-health-insurance-service-sample-cohort-database
#11
Doo-Ho Lim, Ye-Jee Kim, Seon Ok Kim, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
OBJECTIVES: The aims of our study were to determine whether the use of conventional disease-modifying antirheumatic drugs (cDMARDs) or tumor necrosis factor α (TNFα) inhibitors increase the risk of herpes zoster (HZ) in patients with ankylosing spondylitis (AS). METHODS: We searched the South Korean National Health Insurance Service - National Sample Cohort Database for relevant patient records between 2002 and 2013. We evaluated the incidence of HZ by categorizing patients into in three treatment groups: disease-modifying antirheumatic drug (DMARD) nonusers, cDMARD users and TNFα inhibitor users...
May 26, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28545047/the-natural-history-of-varicella-zoster-virus-infection-in-norway-further-insights-on-exogenous-boosting-and-progressive-immunity-to-herpes-zoster
#12
Luigi Marangi, Grazina Mirinaviciute, Elmira Flem, Gianpaolo Scalia Tomba, Giorgio Guzzetta, Birgitte Freiesleben de Blasio, Piero Manfredi
We use age-structured models for VZV transmission and reactivation to reconstruct the natural history of VZV in Norway based on available pre-vaccination serological data, contact matrices, and herpes zoster incidence data. Depending on the hypotheses on contact and transmission patterns, the basic reproduction number of varicella in Norway ranges between 3.7 and 5.0, implying a vaccine coverage between 73 and 80% to effectively interrupt transmission with a 100% vaccine efficacy against infection. The varicella force of infection peaks during early childhood (3-5 yrs) and shows a prolonged phase of higher risk during the childbearing period, though quantitative variations can occur depending on contact patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28530894/preventing-herpes-zoster-through-vaccination-new-developments
#13
REVIEW
Phuc Le, Camille Sabella, Michael B Rothberg
Herpes zoster (HZ) affects 1 million Americans every year. The disease burden is higher in immunocompromised patients. The live-attenuated HZ vaccine is effective in preventing HZ and postherpetic neuralgia and has been recommended for immunocompetent adults age 60 and older. However, because protection wanes by 10 years, a booster may be necessary. In 2015, an adjuvanted subunit HZ vaccine was shown to reduce incidence by 97%, even in the elderly, but long-term data on vaccine protection are not available...
May 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28528766/when-zoster-hits-close-to-home-impact-of-personal-zoster-awareness-on-zoster-vaccine-uptake-in-the-u-s
#14
Rafael Harpaz, Jessica Leung
U.S. zoster vaccine uptake has been sluggish. Most adults are aware of zoster but unaware of its distressing manifestations. We found that vaccine uptake is markedly increased immediately following occurrence of zoster in a spouse. Thus, personal zoster awareness can prompt vaccination. Our findings have implications in terms of both vaccine promotion and interpretations of vaccine performance.
May 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28525973/varicella-zoster-virus-seroprevalence-in-children-and-adolescents-in-the-pre-varicella-vaccine-era-germany
#15
Miriam Wiese-Posselt, Anette Siedler, Annette Mankertz, Andreas Sauerbrei, Hartmut Hengel, Ole Wichmann, Christina Poethko-Müller
BACKGROUND: In 2004, universal childhood varicella vaccination was introduced in Germany. We aimed to determine the age-specific prevalence of anti-varicella zoster virus (VZV) IgG-antibodies among children in the pre-varicella vaccine era in Germany, to identify factors associated with VZV seropositivity, and to assess the suitability of a commercially available ELISA for VZV seroepidemiological studies by comparing it with an in-house fluorescent antibody to membrane antigen test (FAMA) as the gold standard...
May 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28516725/the-need-for-better-preventative-strategies-for-inflammatory-bowel-disease-patients-at-risk-of-herpes-zoster-virus
#16
William Bye, Miles Sparrow, Susie Connor, Jane Andrews, Katie Ellard, Watson Ng, Georgia Hume, Sally Antoniades, Alissa Walsh
BACKGROUND: Immunosuppressed IBD patients have an increased risk of HZV infection. The existing live-attenuated HZV vaccine is contraindicated in some of these patients and can only be used with caution in others. AIMS: To describe characteristics of IBD patients suffering HZV to enable implementation of risk mitigation strategies for those at highest risk. METHODS: Gastroenterologists completed a proforma for IBD patients who experienced HZV infection: IBD phenotype, details of HZV infection, immunosuppression and any change to treatment upon diagnosis of HZV...
May 17, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28508307/duration-of-antiviral-prophylaxis-and-risk-of-herpes-zoster-among-patients-receiving-autologous-hematopoietic-stem-cell-transplants-a-retrospective-observational-study
#17
Dongmu Zhang, Thomas Weiss, Yu Feng, Lynn Finelli
INTRODUCTION: There are no real-world data on antiviral prophylaxis (AP) duration and risk of herpes zoster (HZ) given AP duration in patients receiving autologous hematopoietic stem cell transplants (auto-HSCT). The objectives of this study are to describe the duration of AP and to compare incidence of HZ by AP duration in auto-HSCT patients. METHODS: This is a retrospective, observational database (Marketscan(®)) study. This study included patients ≥18 years old who had auto-HSCT during 2009-2013, had chemotherapy within 60 days prior to auto-HSCT (latest chemotherapy date within the 60 days was the study enrollment date), and had continuous health plan enrollment for at least 365 days before and after the study enrollment date...
May 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28502771/metabolic-phenotypes-of-response-to-vaccination-in-humans
#18
Shuzhao Li, Nicole L Sullivan, Nadine Rouphael, Tianwei Yu, Sophia Banton, Mohan S Maddur, Megan McCausland, Christopher Chiu, Jennifer Canniff, Sheri Dubey, Ken Liu, ViLinh Tran, Thomas Hagan, Sai Duraisingham, Andreas Wieland, Aneesh K Mehta, Jennifer A Whitaker, Shankar Subramaniam, Dean P Jones, Alessandro Sette, Kalpit Vora, Adriana Weinberg, Mark J Mulligan, Helder I Nakaya, Myron Levin, Rafi Ahmed, Bali Pulendran
Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Vaccination induces robust antigen-specific antibody, plasmablasts, and CD4(+) T cells yet limited CD8(+) T cell and antiviral responses...
May 18, 2017: Cell
https://www.readbyqxmd.com/read/28501259/risk-of-stroke-transient-ischemic-attack-or-myocardial-infarction-with-herpes-zoster-a-systematic-review-and-meta-analysis
#19
Yanting Zhang, Ganfeng Luo, Yuanwei Huang, Qiuyan Yu, Li Wang, Ke Li
BACKGROUND: Accumulating evidence indicates that herpes zoster (HZ) may increase the risk of stroke/transient ischemic attack (TIA) or myocardial infarction (MI), but the results are inconsistent. We aim to explore the relationship between HZ and risk of stroke/TIA or MI and between herpes zoster ophthalmicus (HZO) and stroke. METHODS: We estimated the relative risk (RR) and 95% confidence intervals (CIs) with the meta-analysis. Cochran's Q test and Higgins I(2) statistic were used to check for heterogeneity...
May 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28486850/vaccine-profile-of-herpes-zoster-hz-su-subunit-vaccine
#20
Anthony L Cunningham, Thomas Heineman
Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-related or other causes of decreased T cell immunity. A live attenuated vaccine boosts this immunity and provides partial protection against HZ, but this decreases with age and declines over 8 years. Areas covered: A new HZ subunit (HZ/su) vaccine combines a key surface VZV glycoprotein (E) with a T cell-boosting adjuvant system (AS01B) and is administered by two intramuscular injections two months apart...
July 2017: Expert Review of Vaccines
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