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https://www.readbyqxmd.com/read/28204894/genotype-analysis-of-orf-62-identifies-varicella-zoster-virus-infections-caused-by-a-vaccine-strain-in-children
#1
Byung Ok Kwak, Hoan Jong Lee, Hyun Mi Kang, Chi Eun Oh, Eun Hwa Choi
This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. A genotype analysis of ORF 22 amino acids revealed genotype J in all children except one...
February 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28197700/-the-alpha-herpesviridae-in-dermatology-varicella-zoster-virus-german-version
#2
REVIEW
L El Hayderi, A Rübben, A F Nikkels
The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal...
February 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28197697/the-alpha-herpesviridae-in-dermatology-varicella-zoster-virus
#3
REVIEW
L El Hayderi, A Rübben, A F Nikkels
The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal...
February 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28174201/safety-of-second-dose-single-antigen-varicella-vaccine
#4
John R Su, Zanie Leroy, Paige W Lewis, Penina Haber, Mona Marin, Jessica Leung, Emily Jane Woo, Tom T Shimabukuro
BACKGROUND AND OBJECTIVE: In 2006, routine 2-dose varicella vaccination for children was recommended to improve control of varicella. We assessed the safety of second-dose varicella vaccination. METHODS: We identified second-dose single-antigen varicella vaccine reports in the Vaccine Adverse Event Reporting System during 2006 to 2014 among children aged 4 to 18 years. We analyzed reports by age group (4-6 and 7-18 years), sex, serious or nonserious status, most common adverse events (AEs), and whether other vaccines were administered concomitantly with varicella vaccine...
February 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28162821/safety-of-live-vaccinations-on-immunosuppressive-therapy-in-patients-with-immune-mediated-inflammatory-diseases-solid-organ-transplantation-or-after-bone-marrow-transplantation-a-systematic-review-of-randomized-trials-observational-studies-and-case-reports
#5
REVIEW
Evelina Croce, Christoph Hatz, Emile F Jonker, L G Visser, Veronika K Jaeger, Silja Bühler
BACKGROUND: Live vaccines are generally contraindicated on immunosuppressive therapy due to safety concerns. However, data are limited to corroborate this practice. OBJECTIVES: To estimate the safety of live vaccinations in patients with immune-mediated inflammatory diseases (IMID) or solid organ transplantation (SOT) on immunosuppressive treatment and in patients after bone-marrow transplantation (BMT). DATA SOURCES: A search was conducted in electronic databases (Cochrane, Pubmed, Embase) and additional literature was identified by targeted searches...
February 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28157251/varicella-a-potential-threat-to-maternal-and-fetal-health
#6
Maria Biskupska, Ilona Małecka, Joanna Stryczyńska-Kazubska, Jacek Wysocki
OBJECTIVES: The aim of the study was to evaluate the following: i) number of midwives and nurses at risk for contracting varicella; ii) effectiveness of infectious disease prevention among healthcare personnel; iii) attitude of healthcare person-nel towards immunization. MATERIAL AND METHODS: A total of 524 midwives and nurses from obstetric, neonatal, and pediatric wards were investigated. Quantitative data analysis was performed. RESULTS: Overall, 14...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28154282/the-successful-treatment-of-a-cord-blood-transplant-recipient-with-varicella-zoster-virus-meningitis-radiculitis-and-myelitis-with-foscarnet
#7
Ryo Shimizu, Chikako Ohwada, Yuhei Nagao, Emi Togasaki, Chika Kawajiri, Tomoya Muto, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Emiko Sakaida, Tohru Iseki, Chiaki Nakaseko
Infections of the central nervous system (CNS) with varicella zoster virus (VZV) is a rare occurrence after allogeneic hematopoietic stem cell transplantation. We herein report a case of VZV meningitis, radiculitis and myelitis that developed 8 months after cord blood transplantation, shortly after the cessation of cyclosporine and low-dose acyclovir. Although treatment with acyclovir did not achieve a satisfactory response, the patient was successfully treated with foscarnet. Our report indicates that VZV infection should be considered in allo-hematopoietic stem cell transplantation (HSCT) patients with CNS symptoms and that foscarnet may be effective for the treatment of acyclovir-resistant VZV infections of the CNS...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28128811/-herpes-zoster-and-post-herpetic-neuralgia-in-the-elderly-particularities-in-prevention-diagnosis-and-treatment
#8
Ana Isabel García-González, Oscar Rosas-Carrasco
Herpes zoster (HZ) results from the reactivation of the varicella zoster virus latent in the sensory ganglia when cell-mediated immunity is altered. It is a frequent condition in older adults, leading to undesirable adverse outcomes. Aging is its main risk factor and the elderly may have different clinical presentations: zoster sine herpete, and a higher incidence of post-herpetic neuralgia (15%) and ophthalmic herpes (7%). Both HZ and post-herpetic neuralgia may impact the quality of life, functional status, mental health, and social interaction in older adults...
January 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28114461/in-adults-%C3%A2-%C3%A2-70-years-of-age-an-adjuvanted-herpes-zoster-subunit-vaccine-reduced-herpes-zoster-at-a-mean-3-7-years
#9
Henry S Sacks
No abstract text is available yet for this article.
January 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28094831/barnvaccinationsprogrammet-%C3%A2-effektivt-men-otillr%C3%A3-ckligt-erfarenheter-fr%C3%A3-n-astrid-lindgrens-barnsjukhus-2008%C3%A2-2013
#10
Åsa Laestadius, Anna Nilsson, Rutger Bennet, Gordana Bogdanovic, Margareta Eriksson
The national Swedish immunisation programme includes vaccine against diphtheria, tetanus, polio, pertussis, Haemophilus influenzae type B, Pneumococcus as well as measles, mumps and rubella. Data were collected on hospital admissions for children 0- 17 years of age of vaccine-preventable diseases during 2008-2013 at Astrid Lindgren Children's Hospital, Stockholm. Patients were identified by discharge diagnosis codes as well as from the clinical microbiology laboratory. There were rare cases of measles and mumps, and only a few cases of invasive bacterial diseases...
January 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28079621/effects-of-education-and-information-on-vaccination-behavior-in-patients-with-inflammatory-bowel-disease
#11
Sofie Coenen, Ellen Weyts, Cedric Jorissen, Paul De Munter, Maja Noman, Vera Ballet, Séverine Vermeire, Gert Van Assche, Marc Ferrante
BACKGROUND: Despite the existence of international guidelines, vaccination in patients with inflammatory bowel disease (IBD) has not been integrated optimally. We developed a thorough education program, and compared its influence on vaccination rates with routine clinical practice in a tertiary IBD center. METHODS: Between December 2014 and March 2015, we included 505 consecutive patients with IBD visiting our outpatient clinic (53% men, 72% Crohn's disease, median age 44 years)...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28068212/immunogenicity-and-safety-of-an-adjuvanted-herpes-zoster-subunit-candidate-vaccine-in-adults-%C3%A2-50%C3%A2-years-of-age-with-a-prior-history-of-herpes-zoster-a-phase-iii-non-randomized-open-label-clinical-trial
#12
Olivier Godeaux, Martina Kovac, Daniel Shu, Katrijn Grupping, Laura Campora, Martine Douha, Thomas C Heineman, Himal Lal
This phase III, non-randomized, open-label, multi-center study (NCT01827839) evaluated the immunogenicity and safety of an adjuvanted recombinant subunit herpes zoster (HZ) vaccine (HZ/su) in adults aged ≥50 years with prior physician-documented history of HZ. Participants (stratified by age: 50-59, 60-69 and ≥70 years) received 2 doses of HZ/su 2 months apart and were followed-up for another 12 months. Anti-glycoprotein E (gE) antibodies were measured by enzyme-linked immunosorbent assay before vaccination and 1 month after the second dose (Month 3)...
January 9, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28042124/improvement-in-herpes-zoster-vaccination-in-patients-with-rheumatoid-arthritis-a-quality-improvement-project
#13
Heena Sheth, Larry Moreland, Hilary Peterson, Rohit Aggarwal
OBJECTIVE: To improve herpes zoster (HZ) vaccination rates in high-risk patients with rheumatoid arthritis (RA) being treated with immunosuppressive therapy. METHODS: This quality improvement project was based on the pre- and post-intervention design. The project targeted all patients with RA over the age of 60 years while being treated with immunosuppressive therapy (not with biologics) seen in 13 rheumatology outpatient clinics. The study period was from July 2012 to June 2013 for the pre-intervention and February 2014 to January 2015 for the post-intervention phase...
January 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28017915/natural-recombination-in-alphaherpesviruses-insights-into-viral-evolution-through-full-genome-sequencing-and-sequence-analysis
#14
REVIEW
Carlos A Loncoman, Paola K Vaz, Mauricio Jc Coppo, Carol A Hartley, Francisco J Morera, Glenn F Browning, Joanne M Devlin
Recombination in alphaherpesviruses was first described more than sixty years ago. Since then, different techniques have been used to detect recombination in natural (field) and experimental settings. Over the last ten years, next-generation sequencing (NGS) technologies and bioinformatic analyses have greatly increased the accuracy of recombination detection, particularly in field settings, thus contributing greatly to the study of natural alphaherpesvirus recombination in both human and veterinary medicine...
December 23, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28011413/a-systematic-review-and-meta-analysis-of-seroprevalence-of-varicella-zoster-virus-a-nationwide-population-based-study
#15
REVIEW
Omolbanin Amjadi, Alireza Rafiei, Mohammadreza Haghshenas, Reza Alizadeh Navaei, Reza Valadan, Zahra Hosseini-Khah, Akbar Hedayatizadeh Omran, Mohsen Arabi, Reza Jafari Shakib, Tahoora Mousavi, G Hossein Ashrafi
Varicella zoster virus (VZV) causes chicken pox as a primary infection following which it becomes latent in neurons. It may then reactivate to cause shingles (herpes zoster). Severity of lesions and VZV pathogenicity are depended on the host's immune response and variant in VZV Dr Athina Myrto ChioniIdentification of VZV seroprevalance rate in general population may lead to develop new health strategic managements such as vaccination. Therefore, we aimed to provide a systematic review of the seroprevalence of VZV infection among Iranian population and estimate age- and gender- specific prevalence of VZV...
December 6, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28007549/estimation-of-age-specific-rates-of-reactivation-and-immune-boosting-of-the-varicella-zoster-virus
#16
Isabella Marinelli, Alies van Lier, Hester de Melker, Andrea Pugliese, Michiel van Boven
Studies into the impact of vaccination against the varicella zoster virus (VZV) have increasingly focused on herpes zoster (HZ), which is believed to be increasing in vaccinated populations with decreasing infection pressure. This idea can be traced back to Hope-Simpson's hypothesis, in which a person's immune status determines the likelihood that he/she will develop HZ. Immunity decreases over time, and can be boosted by contact with a person experiencing varicella (exogenous boosting) or by a reactivation attempt of the virus (endogenous boosting)...
November 22, 2016: Epidemics
https://www.readbyqxmd.com/read/27998044/primary-care-screening-and-management-of-comorbidity-in-rheumatoid-arthritis-in-ontario-canada
#17
Jessica Widdifield, Noah M Ivers, Sasha Bernatsky, R Liisa Jaakkimainen, Claire Bombardier, J Carter Thorne, Vandana Ahluwalia, J Michael Paterson, Jacqueline Young, Laura Wing, Karen Tu
OBJECTIVE: Quality measurement for rheumatoid arthritis (RA) patients has largely focused on care provided by rheumatologists. Our aim was to develop and assess quality measures related to the screening and management of comorbidity in RA patients in primary care. METHODS: We used the primary care Electronic Medical Record Administrative data Linked Database in Ontario, Canada. We harmonized Canadian general population and RA clinical recommendations to develop and assess screening, process, and outcome measures...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27997521/laboratory-diagnosis-of-breakthrough-varicella-in-children
#18
Masahiro Watanabe, Hitoshi Ochiai, Masahiro Ito, Manami Negoro, Shigeru Suga, Toshiaki Ihara
BACKGROUND: Breakthrough varicella (BV) develops in vaccinated persons as a result of infection by wild-type varicella zoster virus (VZV) more than 42 days after varicella vaccination. The clinical symptoms are atypical and clinical diagnosis can be difficult. We investigated laboratory-based diagnostic methods that are relatively simple and highly precise in order to conduct accurate surveillance. SUBJECTS AND METHODS: We enrolled 42 patients with suspected BV at two pediatric hospitals, and performed real-time polymerase chain reaction (PCR) on the skin lesions to confirm the BV diagnosis...
December 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27996000/central-role-of-cd169-lymph-node-resident-macrophages-in-the-adjuvanticity-of-the-qs-21-component-of-as01
#19
Sophie Detienne, Iain Welsby, Catherine Collignon, Sandrine Wouters, Margherita Coccia, Sophie Delhaye, Laurye Van Maele, Séverine Thomas, Maëlle Swertvaegher, Aurélie Detavernier, Abdelatif Elouahabi, Stanislas Goriely, Arnaud M Didierlaurent
Saponins represent a promising class of vaccine adjuvant. Together with the TLR4-ligand MPL, QS-21 is part of the Adjuvant System AS01, a key component of the malaria and zoster candidate vaccines that display demonstrated clinical efficacy. However, the mechanism of action of QS-21 in this liposomal formulation is poorly understood. Upon intra-muscular immunisation, we observed that QS-21 rapidly accumulated in CD169(+) resident macrophages of the draining lymph node where it elicited a local innate immune response...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27986511/anaphylaxis-after-zoster-vaccine-implicating-alpha-gal-allergy-as-a-possible-mechanism
#20
Cosby A Stone, Jonathan A Hemler, Scott P Commins, Alexander J Schuyler, Elizabeth J Phillips, R Stokes Peebles, John M Fahrenholz
No abstract text is available yet for this article.
December 14, 2016: Journal of Allergy and Clinical Immunology
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