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https://www.readbyqxmd.com/read/28339574/arm-paralysis-after-routine-childhood-vaccinations-application-of-advanced-molecular-methods-to-the-causality-assessment-of-an-adverse-event-after-immunization
#1
Jana Shaw, Neal A Halsey, Adriana Weinberg, D Scott Schmid, Kirsten St George, William C Weldon, Michael Jordan, Patrick W Bryant, Philip S LaRussa, Deborah Y Bradshaw, Theresa Harrington, Anne Gershon
Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause...
January 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339568/varicella-in-a-previously-immune-patient-with-leukemia
#2
Michelle Sewnarine, Sujatha Rajan, Arlene Redner, Lorry G Rubin
Infection with varicella-zoster virus (VZV) in oncology patients can result in severe disease with an increased risk of morbidity and mortality [1, 2]. Among patients on cancer chemotherapy, only nonimmune persons are considered to be susceptible to varicella [1]. We present a case of varicella in a child with leukemia that occurred despite immunity as defined by 2 doses of varicella vaccine and documentation of positive VZV immunoglobulin G titer before initiation of chemotherapy.
January 19, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28330866/response-to-comment-on-diversification-of-the-antigen-specific-t-cell-receptor-repertoire-after-varicella-zoster-vaccination
#3
Jorg Goronzy, Qian Qi, Cornelia Weyand
In our repertoire studies of varicella zoster virus-specific T cells, we used very stringent computational criteria to keep contamination with T cell receptor sequences from bystander-activated T cells to a minimum.
March 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28330864/comment-on-diversification-of-the-antigen-specific-t-cell-receptor-repertoire-after-varicella-zoster-vaccination
#4
Christophe Parizot, Hélène Brisson, Jehane Fadlallah, Delphine Sterlin, Guy Gorochov
Analysis of antigen-specific T cells can be confounded by T cell activation in vitro.
March 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28320319/cytomegalovirus-epstein-barr-virus-and-varicella-zoster-virus-infection-in-the-first-two-years-of-life-a-cohort-study-in-bradford-uk
#5
Lucy Pembrey, Dagmar Waiblinger, Paul Griffiths, Mauli Patel, Rafaq Azad, John Wright
BACKGROUND: Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. Little is known about the epidemiology of CMV and EBV infections in contemporary UK paediatric populations, particularly whether age at infection differs by ethnic group. METHODS: Children enrolled in the Born in Bradford Allergy and Infection Study had a blood sample taken and a questionnaire completed at 12 and 24 months of age...
March 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28320119/giant-cell-arteritis-following-varicella-zoster-vaccination
#6
Itay Lotan, Israel Steiner
BACKGROUND: Giant cell arteritis (GCA) is a form of large-vessel vasculitis affecting patients older than 50years old. Recent reports have suggested that the condition is caused by reactivation of varicella zoster virus (VZV). If that is indeed the case, a vaccine that prevents VZV reactivation should reduce the incidence of GCA. To further test that hypothesis, we assessed the incidence of GCA among patients older than 50years of age who were vaccinated against VZV and compared it to GCA incidence in the general population...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28298565/longterm-effectiveness-of-herpes-zoster-vaccine-among-patients-with-autoimmune-and-inflammatory-diseases
#7
Huifeng Yun, Fenglong Xie, John W Baddley, Kevin Winthrop, Kenneth G Saag, Jeffrey R Curtis
OBJECTIVE: The protection duration of herpes zoster (HZ) vaccination is unclear among patients with autoimmune (AI) diseases. METHODS: Using 2006-2013 Medicare data, HZ vaccinated patients with AI were matched 1:2 to unvaccinated HZ. Incidence rates (IR) and adjusted risk ratios over time were calculated using Poisson regression. RESULTS: Of 59,627 vaccinated patients, crude IR increased from 0.75/100 person-years during the first year post-vaccination to 1...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28298208/looking-back-to-move-forward-a-twenty-year-audit-of-herpes-zoster-in-asia-pacific
#8
REVIEW
Liang-Kung Chen, Hidenori Arai, Liang-Yu Chen, Ming-Yueh Chou, Samsuridjal Djauzi, Birong Dong, Taro Kojima, Ki Tae Kwon, Hoe Nam Leong, Edward M F Leung, Chih-Kuang Liang, Xiaohong Liu, Dilip Mathai, Jiun Yit Pan, Li-Ning Peng, Eduardo Rommel S Poblete, Philip J H Poi, Stewart Reid, Terapong Tantawichien, Chang Won Won
BACKGROUND: Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vulnerable patients. Although widely recommended, vaccination against HZ is not routine; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data. To address knowledge gaps, raise awareness, and disseminate best practice, we reviewed recent data and guidelines on HZ from the Asia-Pacific region...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28291069/two-cases-of-acute-retinal-necrosis-due-to-varicella-zoster-despite-prior-shingles-vaccination
#9
Eric J Weinlander, Angeline L Wang, Pimkwan Jaru-Ampornpan, Michael M Altaweel, T Michael Nork
PURPOSE: To review two cases of acute retinal necrosis in adults due to varicella zoster virus despite prior shingles vaccination. METHODS: Retrospective chart review. PATIENTS: A 62-year-old man and a 64-year-old man with unilateral acute retinal necrosis who had shingles vaccinations 16 and 7 months before their ocular symptoms. RESULTS: Polymerase chain reaction confirmation of varicella zoster virus in the anterior chambers of both patients...
March 13, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28287424/keloid-and-hypertrophic-scars-are-the-result-of-chronic-inflammation-in-the-reticular-dermis
#10
REVIEW
Rei Ogawa
Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. The latter is characterized by continuous and histologically localized inflammation...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28276305/severe-varicella-in-persons-vaccinated-with-varicella-vaccine-breakthrough-varicella-a-systematic-literature-review
#11
Jessica Leung, Karen R Broder, Mona Marin
Varicella vaccines are highly effective at preventing disease, but varicella may occur among vaccinated persons (termed breakthrough varicella). Breakthrough varicella is generally mild, but severe cases have been reported. The objective of this review is to describe severe breakthrough varicella. Areas covered: We conducted a systematic review of articles published during 1974-2016. A total of 34 articles were included in our review: 21 described breakthrough varicella with disseminated varicella-zoster virus (VZV) infection with other organ involvement in addition to skin (none among two-dose vaccinees); 9 described hospitalized breakthrough varicella without mention of other organ involvement in addition to skin (of which 2 reported 4 two-dose vaccinees); and 4 described both...
April 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28270112/a-meta-analysis-of-stroke-risk-following-herpes-zoster-infection
#12
Fawziah Marra, Jeremy Ruckenstein, Kathryn Richardson
BACKGROUND: The incidence of herpes zoster (HZ) is increasing and poses a significant health concern to aging populations. Several studies suggest an increased risk of stroke following zoster infection, but the results are conflicting. We conducted a systematic review and meta-analysis to determine if stroke risk is increased following HZ infection. METHODS: A search of MEDLINE, EMBASE, Google scholar, Web of Science, CAB Direct, Cumulative Index to Nursing and Allied Health Literature, and Evidence Based Medicine Reviews was conducted for observational studies of adults with HZ infection that examined stroke and TIA risk from January 1, 1966 to May 31, 2016...
March 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28268074/safety-and-immunogenicity-of-inactivated-varicella-zoster-virus-vaccine-in-adults-with-hematologic-malignancies-receiving-treatment-with-anti-cd20-monoclonal-antibodies
#13
Janie Parrino, Shelly A McNeil, Steven J Lawrence, Eva Kimby, Marco F Pagnoni, Jon E Stek, Yanli Zhao, Ivan S F Chan, Susan S Kaplan
BACKGROUND: Immunocompromised patients can experience significant morbidity and occasional mortality from complications associated with herpes zoster (HZ), but live attenuated HZ vaccine is contraindicated for these patients. Inactivated zoster vaccine (ZVIN) is in development for prevention of HZ in immunocompromised patients. However, there are limited data in the literature regarding the effect of anti-CD20 monoclonal antibodies on vaccine-related cell-mediated immune response. This study evaluated safety and immunogenicity of ZVIN in patients with hematologic malignancies (HM) receiving anti-CD20 monoclonal antibodies (alone or in combination chemotherapy regimens) and not likely to undergo hematopoietic cell transplant (HCT) (n=80)...
March 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28236463/disseminated-herpes-zoster-after-varicella-vaccination-in-a-healthy-boy
#14
J M Rueda, M Feito-Rodríguez, D Nieto, R de Lucas-Laguna
No abstract text is available yet for this article.
February 21, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28204894/genotype-analysis-of-orf-62-identifies-varicella-zoster-virus-infections-caused-by-a-vaccine-strain-in-children
#15
Byung Ok Kwak, Hoan Jong Lee, Hyun Mi Kang, Chi Eun Oh, Eun Hwa Choi
This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. A genotype analysis of ORF 22 amino acids revealed genotype J in all children except one...
February 15, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28197700/-the-alpha-herpesviridae-in-dermatology-varicella-zoster-virus-german-version
#16
REVIEW
L El Hayderi, A Rübben, A F Nikkels
The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal...
February 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28197697/the-alpha-herpesviridae-in-dermatology-varicella-zoster-virus
#17
REVIEW
L El Hayderi, A Rübben, A F Nikkels
The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal...
February 14, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28174201/safety-of-second-dose-single-antigen-varicella-vaccine
#18
John R Su, Zanie Leroy, Paige W Lewis, Penina Haber, Mona Marin, Jessica Leung, Emily Jane Woo, Tom T Shimabukuro
BACKGROUND AND OBJECTIVE: In 2006, routine 2-dose varicella vaccination for children was recommended to improve control of varicella. We assessed the safety of second-dose varicella vaccination. METHODS: We identified second-dose single-antigen varicella vaccine reports in the Vaccine Adverse Event Reporting System during 2006 to 2014 among children aged 4 to 18 years. We analyzed reports by age group (4-6 and 7-18 years), sex, serious or nonserious status, most common adverse events (AEs), and whether other vaccines were administered concomitantly with varicella vaccine...
February 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28162821/safety-of-live-vaccinations-on-immunosuppressive-therapy-in-patients-with-immune-mediated-inflammatory-diseases-solid-organ-transplantation-or-after-bone-marrow-transplantation-a-systematic-review-of-randomized-trials-observational-studies-and-case-reports
#19
REVIEW
Evelina Croce, Christoph Hatz, Emile F Jonker, L G Visser, Veronika K Jaeger, Silja Bühler
BACKGROUND: Live vaccines are generally contraindicated on immunosuppressive therapy due to safety concerns. However, data are limited to corroborate this practice. OBJECTIVES: To estimate the safety of live vaccinations in patients with immune-mediated inflammatory diseases (IMID) or solid organ transplantation (SOT) on immunosuppressive treatment and in patients after bone-marrow transplantation (BMT). DATA SOURCES: A search was conducted in electronic databases (Cochrane, Pubmed, Embase) and additional literature was identified by targeted searches...
March 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28157251/varicella-a-potential-threat-to-maternal-and-fetal-health
#20
Maria Biskupska, Ilona Małecka, Joanna Stryczyńska-Kazubska, Jacek Wysocki
OBJECTIVES: The aim of the study was to evaluate the following: i) number of midwives and nurses at risk for contracting varicella; ii) effectiveness of infectious disease prevention among healthcare personnel; iii) attitude of healthcare person-nel towards immunization. MATERIAL AND METHODS: A total of 524 midwives and nurses from obstetric, neonatal, and pediatric wards were investigated. Quantitative data analysis was performed. RESULTS: Overall, 14...
2017: Ginekologia Polska
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