keyword
https://read.qxmd.com/read/38417514/monitoring-viruses-and-beta-lactam-resistance-genes-through-wastewater-surveillance-during-a-covid-19-surge-in-suwon-south-korea
#21
JOURNAL ARTICLE
Rajendra Singh, Jaewon Ryu, Sung Soo Park, Sungpyo Kim, Keugtae Kim
The present study reports data on a long-term campaign for monitoring SARS-CoV-2, norovirus, hepatitis A virus, and beta-lactam resistance genes in wastewater samples from a wastewater treatment plant during COVID-19 surge in Suwon, South Korea. Real-time digital PCR (RT-dPCR) assays indicated 100 % occurrence of all but hepatitis A virus and blaNDM gene in influent wastewater samples. CDC-N1 assay detected SARS-CoV-2 in all influent samples with an average log-transformed concentration of 5.1 ± 0...
February 26, 2024: Science of the Total Environment
https://read.qxmd.com/read/38412652/identification-of-phytochemicals-with-inhibitory-potential-against-beta-lactamase-enzymes-via-computer-aided-approach
#22
JOURNAL ARTICLE
Goodness Chizorom Nwokebu, Abdurahman Babatunde Adesina, Clement Ndudi Isibor, Stephen Ayaosi Aigbepue, Chidinma Confidence Egbo, Nelson Pureaziba, Opeyemi Oluwafemi Isaac, Adedoyin John-Joy Owolade, Hafsat Olateju Alabere, Mary Oluchi Iwuagwu, Mutiat Olamide Hussein, Abdulwasiu Ibrahim, Toheeb Adewale Balogun
INTRODUCTION: Antibacterial drugs have been widely used for the past century to treat diseases, but their efficacy has been limited by multi-resistant pathogens, particularly those that utilize beta-lactamase enzymes. The inhibition of beta-lactamase enzymes holds great promise for reducing the influence of such pathogens. OBJECTIVE: This study aims to evaluate the mechanism of inhibition of phytochemicals with antibacterial activity against two classes of beta-lactamases using computational methods...
February 21, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38412427/genome-editing-in-acinetobacter-baumannii-through-enhanced-natural-transformation
#23
JOURNAL ARTICLE
Ilknur Yilmaz, Tulin Ozbek
Acinetobacter baumannii, a multidrug-resistant bacterium has become a significant cause of life-threatening infections acquired in hospitals worldwide. The existing drugs used to treat A. baumannii infections are rapidly losing efficacy, and the increasing antimicrobial resistance, which is expected to turn into a global health crisis, underscores the urgency to develop novel prevention and treatment strategies. We reasoned that the discovery of novel virulence targets for vaccine and therapy interventions requires a more enhanced method for the introduction of multiple elements of foreign DNA for genome editing than the current methods of natural transformation techniques...
February 27, 2024: Journal of Basic Microbiology
https://read.qxmd.com/read/38407990/the-epidemiology-of-inflammatory-bowel-diseases-during-the-covid-19-pandemic-comparison-of-two-nationwide-cohorts
#24
JOURNAL ARTICLE
Ohad Atia, Nicklas Bryder, Adi Mendelovici, Natan Ledderman, Amir Ben-Tov, Mehdi Osooli, Anders Forss, Yiska Loewenberg Weisband, Eran Matz, Iris Dotan, Dan Turner, Ola Olén
BACKGROUND: We aimed to explore the epidemiology of inflammatory bowel diseases (IBD) in association with the COVID-19 pandemic in two countries with different lockdown policies. METHODS: We utilized nationwide IBD cohorts in Israel and Sweden to explore the incidence of IBD during the pandemic compared to three years prior (2017- 2019). We examined temporal trends through the presence of inflection points by Joinpoint regression analysis and reported average monthly percentage changes (AMPC)...
February 26, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38399246/potentiation-of-antibiotic-activity-of-aztreonam-against-metallo-%C3%AE-lactamase-producing-multidrug-resistant-pseudomonas-aeruginosa-by-3-o-substituted-difluoroquercetin-derivatives
#25
JOURNAL ARTICLE
Seongyeon Lee, Taegum Lee, Mi Kyoung Kim, Joong Hoon Ahn, Seri Jeong, Ki-Ho Park, Youhoon Chong
The combination of aztreonam (ATM) and ceftazidime-avibactam (CAZ-AVI; CZA) has shown therapeutic potential against serine-β-lactamase (SBL)- and metallo-β-lactamase (MBL)-producing Enterobacterales . However, the ability of CZA to restore the antibiotic activity of ATM is severely limited in MBL-producing multidrug-resistant (MDR) Pseudomonas aeruginosa strains because of the myriad of intrinsic and acquired resistance mechanisms associated with this pathogen. We reasoned that the simultaneous inhibition of multiple targets associated with multidrug resistance mechanisms may potentiate the antibiotic activity of ATM against MBL-producing P...
January 28, 2024: Pharmaceutics
https://read.qxmd.com/read/38385742/whole-genome-sequence-based-molecular-characterization-of-blood-isolates-of-carbapenem-resistant-enterobacter-cloacae-complex-from-icu-patients-in-kolkata-india-during-2017-2022-emergence-of-phylogenetically-heterogeneous-enterobacter-hormaechei-subsp-xiangfangensis
#26
JOURNAL ARTICLE
Gourab Halder, Bhaskar Narayan Chaudhury, Subhranshu Mandal, Priyanka Denny, Deotima Sarkar, Mandira Chakraborty, Ujjwayini Ray Khan, Soma Sarkar, Bedobroto Biswas, Arindam Chakraborty, Sourav Maiti, Shanta Dutta
Blood-borne infections caused by the carbapenem-resistant Enterobacter cloacae complex (CR-ECC) are major public threats with respect to the challenges encountered during treatment. This study describes the whole genome sequencing-based molecular characteristics of blood isolates ( n = 70) of CR-ECC from patients admitted to the intensive care unit of tertiary care hospitals in Kolkata, India, during 2017-2022 with respect to species identification, antimicrobial resistance (AMR) profiling, mechanism of drug resistance, and molecular subtypes...
February 22, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38367844/enterobacterales-carrying-chromosomal-ampc-%C3%AE-lactamases-in-europe-euescpm-epidemiology-and-antimicrobial-resistance-burden-from-a-cohort-of-27-hospitals-2020-2022
#27
JOURNAL ARTICLE
Matteo Boattini, Gabriele Bianco, Laura Iglesias Llorente, Laura Alonso Acero, Daniel Nunes, Miguel Seruca, Vasco Santos Mendes, André Almeida, Paulo Bastos, Ángel Rodríguez-Villodres, Adelina Gimeno Gascón, Ana Verónica Halperin, Rafael Cantón, Maria Nieves Larrosa Escartín, Juan José González-López, Pauline Floch, Clémence Massip, Delphine Chainier, Olivier Barraud, Laurent Dortet, Gaëlle Cuzon, Clément Zancanaro, Assaf Mizrahi, Rogier Schade, Asger Nellemann Rasmussen, Kristian Schønning, Axel Hamprecht, Lukas Schaffarczyk, Stefan Glöckner, Jürgen Rödel, Katalin Kristóf, Ágnes Balonyi, Stefano Mancini, Chantal Quiblier, Teresa Fasciana, Anna Giammanco, Bianca Paglietti, Salvatore Rubino, Ana Budimir, Branka Bedenić, Zana Rubic, Jelena Marinović, Konstantina Gartzonika, Eirini Christaki, Viktoria Eirini Mavromanolaki, Sofia Maraki, Tuğba Yanık Yalçın, Özlem Kurt Azap, Monica Licker, Corina Musuroi, Daniela Talapan, Vrancianu Corneliu Ovidiu, Sara Comini, Patrycja Zalas-Więcek, Anna Michalska, Rossana Cavallo, José Melo Cristino, Cristina Costa
INTRODUCTION: The ESCPM group (Enterobacter species including Klebsiella aerogenes - formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex, Providencia species and Morganella morganii) has not yet been incorporated into systematic surveillance programs. METHODS: We conducted a multicentre retrospective observational study analysing all ESCPM strains isolated from blood cultures in 27 European hospitals over a three-year period (2020-2022)...
February 15, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38354981/commonly-associated-aerobic-microbial-pathogens-and-their-antibiotic-susceptibility-profile-in-diabetic-foot-ulcers-in-tertiary-care-centre-in-western-maharashtra
#28
JOURNAL ARTICLE
Madineni Madhukar, Prachi V Athavale, Nageswari R Gandham, Chanda R Vyawahare, Virendra S Athavale
PURPOSE: Diabetes mellitus (DM-II) is a metabolic disorder either due to reduced insulin production or reduced insulin sensitivity. Diabetic foot ulcer (DFU) is one of the most devastating complications of DM-II. This study was performed to assess commonly isolated micro-organisms and their anti-microbial sensitivity pattern in diabetic foot ulcers in a tertiary care centre in Western Maharashtra. METHODS: Adult patients with a known case of DM-II with foot lesions, suspected to be a Diabetic Foot Infections (DFIs) at the tertiary care hospital from Aug 2022 to Sept 2022 were included in the study...
February 16, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38342378/evaluation-of-clinical-and-microbiological-factors-related-to-mortality-in-patients-with-gram-negative-bacterial-infections-treated-with-ceftazidime-avibactam-a-prospective-multicentric-cohort-study
#29
JOURNAL ARTICLE
Beatriz Arns, Guilherme Geraldo Lovato Sório, Tarsila Vieceli, Dariane Pereira, Andrea Souza, Priscila Wink, Dariane Pereira, Julia Hoefel Paes, Leonardo David, Fernanda Barboza, Stella Hickmann, Gustavo Alves, Antônio Cândido Santos, Anelise da Rosa, Marcelle Alves, Cibele Magagnin, Eduardo Gomes, Alexandre Prehn Zavascki, Maria Helena Rigatto
OBJECTIVES: This study aimed to evaluate the clinical and microbiological risk factors associated with mortality in patients treated with ceftazidime-avibactam for carbapenem-resistant gram-negative bacterial infections. METHODS: This multicentric prospective cohort study included hospitalized adult patients with a microbiologically confirmed infection treated with ceftazidime-avibactam for ≥48 hours. The clinical and microbiological risk factors for 30-day mortality were evaluated using a Cox regression model...
February 9, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38322997/diverse-bacteriophages-for-biocontrol-of-esbl-and-ampc-%C3%AE-lactamase-producing-e-%C3%A2-coli
#30
JOURNAL ARTICLE
Amira R Vitt, Anders Nørgaard Sørensen, Martin S Bojer, Valeria Bortolaia, Martine C Holst Sørensen, Lone Brøndsted
Novel solutions are needed to reduce the risk of transmission of extended spectrum β-lactamase (ESBL) and AmpC β-lactamase producing Escherichia coli (ESBL/AmpC E. coli ) from livestock to humans. Given that phages are promising biocontrol agents, a collection of 28 phages that infect ESBL/AmpC E. coli were established. Whole genome sequencing showed that all these phages were unique and could be assigned to 15 different genera. Host range analysis showed that 82% of 198 strains, representing the genetic diversity of ESBL/AmpC E...
February 16, 2024: IScience
https://read.qxmd.com/read/38319833/efficacy-of-cefoperazone-sulbactam-for-esbl-producing-escherichia-coli-and-klebsiella-pneumoniae-bacteraemia-and-the-factors-associated-with-poor-outcomes
#31
JOURNAL ARTICLE
Rou-Zhen Chen, Po-Liang Lu, Tsung-Ying Yang, Shang-Yi Lin, Hung-Jen Tang, Feng-Yee Chang, Ya-Sung Yang, Tsung-Ta Chiang, Fu-Der Wang, Ting-Shu Wu, Shian-Sen Shie, Mao-Wang Ho, Jien-Wei Liu, Zhi-Yuan Shi, Chia-Hui Chou, Yin-Ching Chuang
OBJECTIVE: We aimed to assess the efficacy of cefoperazone/sulbactam (CPZ/SUL) in extended-spectrum β-lactamase (ESBL)-producing Enterobacterales infections and identify factors influencing outcomes. METHODS: This retrospective multicentre study was conducted in Taiwan (January 2015 to December 2020) and examined the efficacy of CPZ/SUL treatment in ESBL-producing Enterobacterales bacteraemia. The minimum inhibitory concentrations (MICs) were determined using agar dilution; ESBL/AmpC genes were detected using polymerase chain reaction...
February 6, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38319508/reduced-susceptibility-to-aztreonam-avibactam-conferred-by-acquired-ampc-type-%C3%AE-lactamases-in-pbp3-modified-escherichia-coli
#32
JOURNAL ARTICLE
Nicolas Helsens, Mustafa Sadek, Christophe Le Terrier, Laurent Poirel, Patrice Nordmann
PURPOSE: Carbapenemase-producing Enterobacterales are a growing threat, and very few therapeutic options remain active against those multidrug resistant bacteria. Aztreonam is the molecule of choice against metallo-beta-lactamases (MBL) producers since it is not hydrolyzed by those enzymes, but the co-production of acquired plasmidic cephalosporinases or extended-spectrum β-lactamases leading to aztreonam resistance may reduce the efficacy of this molecule. Hence, the development of the aztreonam-avibactam (AZA) combination provides an interesting therapeutic alternative since avibactam inhibits the activity of both cephalosporinases and extended-spectrum β-lactamases...
February 6, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38317262/antibiotic-definitive-treatment-in-ventilator-associated-pneumonia-caused-by-ampc-producing-enterobacterales-in-critically-ill-patients-a-prospective-multicenter-observational-study
#33
MULTICENTER STUDY
Matthieu Petit, Frank Bidar, Quentin Fosse, Lucie Lefevre, Marine Paul, Tomas Urbina, Paul Masi, Florent Bavozet, Jérémie Lemarié, Etienne de Montmollin, Chloé Andriamifidy-Berti, Julien Dessajan, Benjamin Zuber, Lara Zafrani, Edwige Peju, Paris Meng, Liliane Charrier, Loic Le Guennec, Marie Simon, Charles-Edouard Luyt, Luc Haudebourg, Guillaume Geri
BACKGROUND: Ventilator associated pneumonia (VAP) due to wild-type AmpC-producing Enterobacterales (wtAE) is frequent in intensive care unit (ICU) patients. Despite a low level of evidence, definitive antimicrobial therapy (AMT) with third generation cephalosporins (3GCs) or piperacillin is discouraged. METHODS: Observational prospective study including consecutive wtAE VAP patients in 20 French ICUs. The primary objective was to assess the association of the choice of definitive AMT, i...
February 5, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38313509/experimental-and-simulation-investigation-of-an-adaptive-model-predictive-control-scheme-model-parametrized-by-orthonormal-basis-function
#34
JOURNAL ARTICLE
Muddu Madakyaru
The closed-loop system's performance in synthesizing model predictive control (MPC) heavily relies on the model used for prediction. In continuously operating plants, a linear model-based MPC is designed based on the operating point's linear model during the commissioning stage. However, if the plant requires significant transitions from its normal operating point, the linear model-based MPC may not be effective. Therefore, to maintain the MPC performance under changing nominal operating conditions, the model (deterministic and stochastic components) needs to be updated to predict every sampling instant...
January 30, 2024: ACS Omega
https://read.qxmd.com/read/38247640/in-vitro-antimicrobial-activity-of-five-newly-approved-antibiotics-against-carbapenemase-producing-enterobacteria-a-pilot-study-in-bulgaria
#35
JOURNAL ARTICLE
Rumyana Markovska, Petya Stankova, Temenuga Stoeva, Emma Keuleyan, Kalina Mihova, Lyudmila Boyanova
To solve the problem with pan-drug resistant and extensively drug-resistant Gram-negative microbes, newly approved drugs such as ceftazidime/avibactam, cefiderocol, plazomicin, meropenem/vaborbactam, and eravacycline have been introduced in practice. The aim of the present study was to collect carbapenemase-producing clinical Enterobacterales isolates, to characterize their carbapenemase genes and clonal relatedness, and to detect their susceptibility to commonly used antimicrobials and the above-mentioned newly approved antibiotics...
January 15, 2024: Antibiotics
https://read.qxmd.com/read/38247597/genotypic-characterization-of-uropathogenic-escherichia-coli-from-companion-animals-predominance-of-st372-in-dogs-and-human-related-st73-in-cats
#36
JOURNAL ARTICLE
Sophie Aurich, Silver Anthony Wolf, Ellen Prenger-Berninghoff, Lakshmipriya Thrukonda, Torsten Semmler, Christa Ewers
Extraintestinal pathogenic Escherichia coli (ExPEC) account for over 80% and 60% of bacterial urinary tract infections (UTIs) in humans and animals, respectively. As shared uropathogenic E. coli (UPEC) strains have been previously reported among humans and pets, our study aimed to characterize E. coli lineages among UTI isolates from dogs and cats and to assess their overlaps with human UPEC lineages. We analysed 315 non-duplicate E. coli isolates from the UT of dogs (198) and cats (117) collected in central Germany in 2019 and 2020 utilizing whole genome sequencing and in silico methods...
December 30, 2023: Antibiotics
https://read.qxmd.com/read/38247589/phenotypic-detection-of-carbapenemase-and-ampc-%C3%AE-lactamase-production-among-extended-spectrum-%C3%AE-lactamase-esbl-producing-escherichia-coli-and-klebsiella-spp-isolated-from-clinical-specimens
#37
JOURNAL ARTICLE
Zakaria Garba, Bérenger Kaboré, Isidore J O Bonkoungou, Magloire H Natama, Toussaint Rouamba, Kaisa Haukka, Juha P Kirveskari, Halidou Tinto, Lassana Sangaré, Nicolas Barro, Anu Kantele
Introduction : Data on antimicrobial resistance (AMR) are sparse across numerous African countries, as microbiological analyses are not routinely conducted and surveillance data are not collected. Accordingly, clinical samples are not routinely tested for carbapenem-resistant bacteria and, therefore, the general understanding of their prevalence in the region remains limited. Methods : Between January 2020 and June 2022, we collected extended spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-PE) isolates from five hospitals in Burkina Faso...
December 28, 2023: Antibiotics
https://read.qxmd.com/read/38241346/prevalence-of-drug-resistant-enterobacteriaceae-in-a-nepalese-tertiary-care-hospital
#38
JOURNAL ARTICLE
Anita Bhandari, Saroj Khatiwada, Aashish Sharma, Subhas Chandra Aryal, Raju Shrestha, Nabin Kishor Bimali, Binod Lekhak, Narayan Dutt Pant
Antimicrobial resistance in Enterobacteriaceae is an emerging global public health problem. Numerous studies have reported community-acquired AmpC beta-lactamase and extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in Nepal. However, there are limited data on community-acquired Metallo-beta-lactamase (MBL) producing Enterobacteriaceae. A hospital-based descriptive cross-sectional study was conducted using 294 Enterobacteriaceae isolates from a total of 2,345 different clinical specimens collected from patients attending a tertiary care hospital in Nepal...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38227590/occurrence-and-characteristics-of-extended-spectrum-%C3%AE-lactamase-and-pampc-producing-klebsiella-pneumoniae-isolated-from-companion-animals-with-urinary-tract-infections
#39
JOURNAL ARTICLE
Megan Min Yi Lee, Nan-Ling Kuan, Zhi-Yi Li, Kuang-Sheng Yeh
This study examined 70 Klebsiella pneumoniae isolates derived from companion animals with urinary tract infections in Taiwan. Overall, 81% (57/70) of the isolates carried extended-spectrum β-lactamase (ESBL) and/or plasmid-encoded AmpC (pAmpC) genes. ESBL genes were detected in 19 samples, with blaCTX-M-1, blaCTX-M-9, and blaSHV being the predominant groups. pAmpC genes were detected in 56 isolates, with blaCIT and blaDHA being the predominant groups. Multilocus sequence typing revealed that sequence types (ST)11, ST15, and ST655 were prevalent...
2024: PloS One
https://read.qxmd.com/read/38218982/genomic-diversity-of-%C3%AE-lactamase-producing-pseudomonas-aeruginosa-in-iran-the-impact-of-global-high-risk-clones
#40
JOURNAL ARTICLE
Nazila Ahmadi, Himen Salimizand, Abolfazl Rafati Zomorodi, Jalileh Ebn Abbas, Rashid Ramazanzadeh, Fakhri Haghi, Sepideh Hassanzadeh, Mojdeh Jahantigh, Mojtaba Shahin
BACKGROUND: Hospital-acquired infections caused by multidrug-resistant Pseudomonas aeruginosa incline hospital stay and costs of treatment that resulted in an increased mortality rate. The frequency of P. aeruginosa high-risk clones producing carbapenemases was investigated in our clinical samples. METHODS: In this cross-sectional study, 155 non-repetitive P. aeruginosa isolates were included from different medical centers of Iran. Antibiotic susceptibility testing was determined, and the presence of β-lactamases were sought by phenotypic and genotypic methods...
January 13, 2024: Annals of Clinical Microbiology and Antimicrobials
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