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https://www.readbyqxmd.com/read/28343745/feasibility-of-sulfate-calcined-eggshells-for-removing-pathogenic-bacteria-and-antibiotic-resistance-genes-from-landfill-leachates
#1
Mao Ye, Mingming Sun, Xu Chen, Yanfang Feng, Jinzhong Wan, Kuan Liu, Da Tian, Manqiang Liu, Jun Wu, Arthur P Schwab, Xin Jiang
High abundance of human pathogen and antibiotic resistance genes (ARGs) in landfill leachate has become an emerging threat against human health. Therefore, sulfate- and calcination-modified eggshells as green agricultural bioresource were applied to test the feasibility of removing pathogenic bacteria and ARGs from leachate. The highest removal of Escherichia coli (E. coil) and gentamycin resistant gene (gmrA) from artificial contaminated landfill leachate was achieved by the application of eggshell with combined treatment of sulfate and calcination...
March 23, 2017: Waste Management
https://www.readbyqxmd.com/read/28339845/expanded-spectrum-%C3%AE-lactamase-producing-escherichia-coli-isolated-from-chickens-with-colibacillosis-in-egypt
#2
D A El-Shazly, S A Nasef, F F Mahmoud, Daniel Jonas
Throughout the world, expanded spectrum β-lactamases (ESBL) are increasing among clinical isolates of Enterobacteriaceae, both in humans and animals. Unfortunately, there is a paucity of data on ESBL or Ampicillin class C β-lactamase (AmpC) in Egypt, although antimicrobial consumption is high in this developing country. This study aims to characterize the resistance mechanisms to expanded spectrum cephalosporins among resistant veterinary Escherichia coli isolates in Egypt. We investigated 50 clinical multi-resistant E...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28333332/wck-5222-cefepime-zidebactam-antimicrobial-activity-tested-against-gram-negative-organisms-producing-clinically-relevant-%C3%AE-lactamases
#3
Helio S Sader, Paul R Rhomberg, Robert K Flamm, Ronald N Jones, Mariana Castanheira
Background: Zidebactam is a β-lactam enhancer antibiotic with a dual mechanism of action involving binding to Gram-negative PBP2 and β-lactamase inhibition. Cefepime combined with zidebactam (WCK 5222) is under clinical development for treatment of Gram-negative infections. Objectives: To evaluate the in vitro activities of cefepime and zidebactam separately and combined at 1:1 and 2:1 ratios when tested against Gram-negative organisms producing the most clinically relevant β-lactamase types...
March 18, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333319/wck-4234-a-novel-diazabicyclooctane-potentiating-carbapenems-against-enterobacteriaceae-pseudomonas-and-acinetobacter-with-class-a-c-and-d-%C3%AE-lactamases
#4
Shazad Mushtaq, Anna Vickers, Neil Woodford, David M Livermore
Background: Several diazabicyclooctanes (DBOs) are under development as inhibitors of class A and C β-lactamases. Inhibition of OXA (class D) carbapenemases is variable, with those of Acinetobacter spp. remaining notably resistant. We describe a novel DBO, WCK 4234 (Wockhardt), with distinctive activity against OXA carbapenemases. Methods: MICs of imipenem and meropenem were determined by CLSI agar dilution with WCK 4234 added at 4 or 8 mg/L. Test organisms were clinical Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa with carbapenemases or carbapenem resistance via porin loss plus AmpC or ESBL activity...
February 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333298/occurrence-and-molecular-characteristics-of-esbl-ampc-producing-escherichia-coli-in-faecal-samples-from-horses-in-an-equine-clinic
#5
Ilias Apostolakos, Eelco Franz, Angela H A M van Hoek, Alice Florijn, Christiaan Veenman, Marianne M Sloet-van Oldruitenborgh-Oosterbaan, Cindy Dierikx, Engeline van Duijkeren
Objectives: To investigate the occurrence and characteristics of ESBL/AmpC-producing Escherichia coli in faecal samples from horses at one equine clinic in the Netherlands. Methods: A total of 91 horses, including residents and patients, were sampled. ESBL/AmpC-producing E. coli were identified by a combination disc diffusion test. Phylogenetic groups and MLST were determined. ESBL/AmpC genes were analysed using PCR and sequencing. Plasmids were characterized by transformation and PCR-based replicon typing...
March 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28328967/phenotypic-and-molecular-characterization-of-antimicrobial-resistance-in-enterobacter-spp-isolates-from-companion-animals-in-japan
#6
Kazuki Harada, Takae Shimizu, Yujiro Mukai, Ken Kuwajima, Tomomi Sato, Akari Kajino, Masaru Usui, Yutaka Tamura, Yui Kimura, Tadashi Miyamoto, Yuzo Tsuyuki, Asami Ohki, Yasushi Kataoka
The emergence of antimicrobial resistance among Enterobacter spp., including resistance to extended-spectrum cephalosporins (ESC), is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance among 60 isolates of Enterobacter spp., including E. cloacae (n = 44), E. aerogenes (n = 10), and E. asburiae (n = 6), from clinical specimens of dogs and cats from 15 prefectures in Japan. Furthermore, we characterized the resistance mechanisms harbored by these isolates, including extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR); and assessed the genetic relatedness of ESC-resistant Enterobacter spp...
2017: PloS One
https://www.readbyqxmd.com/read/28320724/piperacillin-tazobactam-versus-other-antibacterial-agents-for-treatment-of-bloodstream-infections-due-to-ampc-beta-lactamase-producing-enterobacteriaceae
#7
Lucy Cheng, Brian C Nelson, Monica Mehta, Nikhil Seval, Sarah Park, Marla J Giddins, Qiuhu Shi, Susan Whittier, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
In vivo induction of AmpC beta-lactamases produces high-level resistance to many beta-lactam antibiotics in Enterobacteriaceae, often resulting in the use of carbapenems or cefepime (FEP). The clinical effectiveness of piperacillin-tazobactam (TZP), a weak inducer of AmpC beta-lactamases, is poorly understood. Here we conducted a case-control study of adult inpatients with bloodstream infections (BSIs) due to Enterobacter, Serratia, or Citrobacter spp. from 2009 to 2015 to assess outcomes following treatment with TZP compared to FEP or meropenem (MEM)...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320396/occurrence-of-bla-dha-1-mediated-cephalosporin-resistance-in-escherichia-coli-and-their-transcriptional-response-against-cephalosporin-stress-a-report-from-india
#8
Birson Ingti, Deepjyoti Paul, Anand Prakash Maurya, Debajyoti Bora, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
BACKGROUND: Treatment alternatives for DHA-1 harboring strains are challenging as it confers resistance to broad spectrum cephalosporins and may further limit treatment option when expressed at higher levels. Therefore, this study was designed to know the prevalence of DHA genes and analyse the transcription level of DHA-1 against different β-lactam stress. METHODS: Screening of AmpC β-lactamase phenotypically by modified three dimensional extract method followed by Antimicrobial Susceptibility and MIC determination...
March 21, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28318579/antimicrobial-susceptibility-and-characterization-of-extended-spectrum-%C3%AE-lactamases-in-escherichia-coli-isolated-from-bovine-mastitic-milk-in-south-korea-from-2012-to-2015
#9
Dong-Seob Tark, Dong Chan Moon, Hee Young Kang, Su-Ran Kim, Hyang-Mi Nam, Hee-Soo Lee, Suk-Chan Jung, Suk-Kyung Lim
In this study, we aimed to assess trends in antimicrobial resistance and to investigate the characteristics of extended-spectrum β-lactamase (ESBL)-producing isolates from bovine mastitic milk from 2012 to 2015. A total of 374 Escherichia coli isolates were analyzed (154 in 2012, 113 in 2013, 76 in 2014, and 31 in 2015). No consistent trends in antimicrobial resistance of E. coli isolates occurred during the 4-yr period. The most frequently observed resistance was tetracycline (23.3%), followed by streptomycin (17...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28314728/competitive-exclusion-reduces-transmission-and-excretion-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-broilers
#10
Daniela Ceccarelli, Alieda van Essen-Zandbergen, Bregtje Smid, Kees T Veldman, Gert Jan Boender, Egil A J Fischer, Dik J Mevius, Jeanet A van der Goot
Extended-spectrum β-lactamases (ESBLs) and plasmid mediated AmpC β-lactamases (pAmpC) are enzymes able to hydrolyze a large variety of β-lactam antibiotics, including 3(rd) generation cephalosporins and monobactams. Broilers and broiler meat products can be highly contaminated with ESBL and pAmpC-producing Escherichia coli, also known as extended-spectrum cephalosporins (ESC)-resistant E. coli, and can be a source for human infections. As few data are available on interventions to reduce ESC-resistant E...
March 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28304216/characterizing-the-multidrug-resistance-of-non-o157-shiga-toxin-producing-escherichia-coli-isolates-from-cattle-farms-and-abattoirs
#11
Carrie-Ann Kennedy, Séamus Fanning, Maria Karczmarczyk, Brian Byrne, Áine Monaghan, Declan Bolton, Torres Sweeney
Non-O157 Shiga toxin-producing Escherichia coli (STECs) are not as well characterized as O157 STEC cases, despite their similar prevalence in many countries. Hence, the objective of this study was to investigate the phenotypic and genotypic basis of multidrug resistance (MDR) in non-O157 STEC farm- and abattoir-sourced isolates and assess the potential dissemination of these MDR profiles in vitro. Susceptibility testing to 20 antimicrobials was performed on 146 non-O157 STECs isolated from farm and abattoir environments...
March 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28289035/wck-5107-zidebactam-wck-5153-novel-inhibitors-of-pbp2-showing-potent-%C3%AE-lactam-enhancer-activity-against-pseudomonas-aeruginosa-including-multidrug-resistant-metallo-%C3%AE-lactamase-producing-high-risk-clones
#12
Bartolome Moya, Isabel M Barcelo, Sachin Bhagwat, Mahesh Patel, German Bou, Krisztina M Papp-Wallace, Robert A Bonomo, Antonio Oliver
Zidebactam and WCK 5153 are novel β-lactam enhancers that are bicyclo-acyl hydrazides (BCH), derivatives of diazabicyclooctane (DBO) scaffold, targeted for the treatment of serious infections caused by highly drug-resistant Gram-negative pathogens. In this report, we determined the PBP inhibition profiles and the antimicrobial activity of zidebactam and WCK 5153 against P. aeruginosa, including multidrug-resistant (MDR) metallo-β-lactamase (MBL)-producing high-risk clones. MICs and time-kill assays were conducted for zidebactam, WCK 5153 and antipseudomonal β-lactams using wild-type PAO1 strain, MexAB-OprM-hyperproducing (mexR), porin deficient (oprD) and AmpC-hyperproducing (dacB) derivatives of PAO1 and MBL-expressing clinical strains, ST175 (blaVIM-2) and ST111 (blaVIM-1)...
March 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28288860/epidemiology-of-multidrug-resistant-gram-negative-pathogens-isolated-from-ventilator-associated-pneumonia-in-icu-patients
#13
Richa Gupta, Abida Malik, Meher Rizvi, Moied Ahmed, Anuradha Singh
OBJECTIVES: Antibiotic resistance among Gram-negative pathogens isolated from ventilator-associated pneumonia (VAP) poses a grave threat in intensive care unit (ICU) patients. The aim of this study was to assess the prevalence of pathogens in ICU patients and their drug resistance profile. The prevalence of extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases and metallo-β-lactamases (MBLs) was also assessed. METHODS: Tracheal aspirates were collected aseptically from 87 ICU patients between May 2012 and January 2014...
March 10, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28276281/in-vitro-susceptibility-and-resistance-phenotypes-in-contemporary-citrobacter-isolates-in-a-university-hospital-in-crete-greece
#14
Sofia Maraki, Konstantinos Z Vardakas, Viktoria-Eirini Mavromanolaki, Margarita Kyriakidou, George Spais, Diamantis P Kofteridis, George Samonis, Matthew E Falagas
BACKGROUND: Data on Citrobacter spp. susceptibility are scarce. We sought to study the evolution in the susceptibility of 385 Citrobacter spp. at the University Hospital of Heraklion, Crete, Greece during a six-year period (2010-2015). METHODS: Non-duplicate strains isolated from inpatients (intensive care unit, oncology, surgery, internal medicine, paediatrics) and outpatients were studied using Vitek 2. Phenotypic confirmatory tests were applied for detection of β-lactamases and aminoglycoside modifying enzymes...
March 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28276133/plasmid-mediated-resistance-to-cephalosporins-and-quinolones-in-escherichia-coli-from-american-crows-in-the-usa
#15
Ivana Jamborova, Monika Dolejska, Ludek Zurek, Andrea K Townsend, Anne B Clark, Julie C Ellis, Ivo Papousek, Alois Cizek, Ivan Literak
American crow (Corvus brachyrhynchos) feces were tested for Escherichia coli with plasmid-mediated quinolone resistance (PMQR), extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases. A total of 590 fecal samples were collected at four roosting sites in the USA and cultivated on selective media. Pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST) were performed to assess clonality. Transferability of resistance genes was studied using conjugation and transformation bioassays...
March 9, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28271652/impact-of-revised-broad-spectrum-cephalosporin-clinical-and-laboratory-standards-institute-breakpoints-on-susceptibility-in-enterobacteriaceae-producing-ampc-%C3%AE-lactamase
#16
Ki Ho Park, Yong Pil Chong, Sung Han Kim, Sang Oh Lee, Mi Suk Lee, Heungsup Sung, Mi Na Kim, Yang Soo Kim, Jun Hee Woo, Sang Ho Choi
We evaluated the impact of revised Clinical and Laboratory Standards Institute (CLSI) breakpoints for broad-spectrum cephalosporins (BSCs) on the susceptibilities of 1,742 isolates of Enterobacter species, Serratia marcescens, Citrobacter freundii, and Morganella morganii. The 2011 CLSI criteria for cefotaxime and ceftazidime reduced the rates of susceptibility by 2.9% and 5.9%, respectively. The 2014 CLSI criteria for cefepime reduced the rate of susceptibility by 13.9%, and categorized 11.8% isolates as susceptible-dose dependent (SDD) for cefepime...
February 28, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28261951/susceptibility-to-disinfectants-in-antimicrobial-resistant-and-susceptible-isolates-of-escherichia-coli-enterococcus-faecalis-and-enterococcus-faecium-from-poultry-esbl-ampc-phenotype-of-escherichia-coli-is-not-associated-with-resistance-to-a-quaternary-ammonium
#17
Nadine Wieland, Julia Boss, Sarah Lettmann, Barbara Fritz, Karin Schwaiger, Johann Bauer, Christina S Hölzel
AIMS: The spread of bacteria that are simultaneously resistant to disinfectants and antimicrobials would constitute an unsettling scenario. In order to explore an association between antimicrobial resistance and reduced susceptibility to biocides / microbicides like disinfectants in agriculture, we investigated Escherichia (E.) coli (n = 438) and enterococci (n = 120) isolated from six different flocks of the same poultry farm with known history of antimicrobial treatment. METHODS AND RESULTS: Susceptibility to disinfectants (formic acid and a quaternary ammonium compound, didecyldimethlyammoniumchloride - DDAC) was assessed by macrodilution (German Veterinary Society)...
March 6, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28258755/unexpected-common-occurrence-of-transferable-extended-spectrum-cephalosporinase-producing-escherichia-coli-in-swedish-surface-waters-used-for-drinking-water-supply
#18
Maria Egervärn, Stina Englund, Marianne Ljunge, Christer Wiberg, Maria Finn, Mats Lindblad, Stefan Börjesson
The presence of Enterobacteriaceae producing extended spectrum beta-lactamases (ESBL) or transferable AmpC beta-lactamases (pAmpC) is increasingly being reported in humans, food-producing animals and food world-wide. However, the occurrence and impact of these so-called extended spectrum cephalosporinase (ESC)-producing Enterobacteriaceae in aquatic environments are poorly documented. This study investigated the occurrence, concentrations and characteristics of ESC-producing E. coli (ESC-Ec) in samples of surface water collected at five Swedish water treatment plants that normally have relatively high prevalence and concentration of E...
February 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28258003/ctx-m-15-and-oxa-10-beta-lactamases-in-multi-drug-resistant-pseudomonas-aeruginosa-first-report-from-pakistan
#19
Waheed Ullah, Muhammad Qasim, Hazir Rahman, Saadullah Khan, Zia Ur Rehman, Nawab Ali, Noor Muhammad
BACKGROUND: Pseudomonas aeruginosa is an emerging threat to public health worldwide due to their rapid development of drug resistance including beta-lactamases. The present study was designed to investigate the incidence of β-lactamases and genotypic pattern of CTX and OXA in the clinical isolate of multidrug resistant P. aeruginosa. METHODS: In this study a total of 102 MDR P. aeruginosa isolates obtained from Lady Reading Hospital, Peshawar, Pakistan were subjected to extended spectrum beta lactamase (ESBL), metallo beta lactamase (MBL) and plasmid mediated β-lactamase (AmpC) detection using phenotypic and molecular methods...
February 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28253356/resistance-to-antimicrobial-drugs-in-different-surface-waters-and-wastewaters-of-guadeloupe
#20
Stéphanie Guyomard-Rabenirina, Celia Dartron, Mélanie Falord, Syndia Sadikalay, Célia Ducat, Vincent Richard, Sébastien Breurec, Olivier Gros, Antoine Talarmin
OBJECTIVE: The first aim of this study was to evaluate the antimicrobial resistance of Enterobacteriaceae in different water environments of Guadeloupe and especially those impacted by waste water treatment plants (WWTP) effluents. The second objective was to characterize the genetic basis for antibiotic resistance of extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase producing Enterobacteriaceae isolates (ESBLE and AmpCE). METHODS: We have collected 70 surface waters (river and sea samples) impacted or not by WWTP and 18 waste waters from 2 WWTPs in 2012 and 2013...
2017: PloS One
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