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https://www.readbyqxmd.com/read/28820112/prevalence-study-of-plasmid-mediated-ampc-%C3%AE-lactamases-in-enterobacteriaceae-lacking-inducible-ampc-from-saudi-hospitals
#1
Baha Abdalhamid, Samar Albunayan, Alaa Shaikh, Nasreldin Elhadi, Reem Aljindan
PURPOSE: Enterobacteriaceae encoding plasmid-mediated AmpC (pAmpC) β-lactamases confer resistance to the third generation cephalosporins. pAmpC association with extended spectrum β-lactamases (ESBLs), plasmid-mediated quinolone resistance (PMQR) and aminoglycoside modifying enzymes (AMEs) is well documented. There are limited data regarding the epidemiology and clinical significance of pAmpC in Saudi Arabia. This study aimed to determine the prevalence of pAmpC and its coexistence with ESBLs, PMQR and AMEs in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis isolates in Saudi hospitals from January to December 2015...
August 18, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28808689/role-of-ampr-in-the-high-expression-of-the-plasmid-encoded-ampc-%C3%AE-lactamase-cfe-1
#2
Ryuichi Nakano, Akiyo Nakano, Hisakazu Yano, Ryoichi Okamoto
CFE-1 is a unique plasmid-encoded AmpC β-lactamase with the regulator gene ampR. It imparts high resistance to most cephalosporins with constitutive high-level β-lactamase activity. Here, the β-lactamase activities and expression levels of ampC with or without ampR were investigated. Results suggested that the resistance of CFE-1 to cephalosporins is caused by a substitution in AmpR, in which the Asp at position 135 is modified to Ala to allow the constitutive high-level expression (derepression) of ampC...
July 2017: MSphere
https://www.readbyqxmd.com/read/28801276/transferability-of-antimicrobial-resistance-from-multidrug-resistant-escherichia-coli-isolated-from-cattle-in-the-united-states-to-escherichia-coli-and-salmonella-newport-recipients
#3
T L Poole, T R Callaway, K N Norman, H M Scott, G H Loneragan, S A Ison, R C Beier, D M Harhay, B Norby, D J Nisbet
OBJECTIVE: To evaluate conjugative transfer of cephalosporin resistance among (n=100) strains of multi-drug resistant Escherichia coli (MDRE) to Salmonella Newport and E. coli DH5α recipients. METHODS: Phenotypic and genotypic profiles were determined for MDRE, Salmonella Newport (trSN) and E. coli DH5α (trDH) transconjugants. RESULTS: Twenty-seven percent (n=26) and 28% (n=27) of (n=95) MDR E. coli donor isolates transferred resistance to trSN and trDH recipient isolates, respectively...
August 8, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28799218/synergy-and-mechanism-of-action-of-%C3%AE-mangostin-and-ceftazidime-against-ceftazidime-resistant-acinetobacter-baumannii
#4
T Pimchan, D Maensiri, G Eumkeb
To address the resistance of Acinetobacter baumannii to β-lactam antibiotics, combination therapy between different antibiotic classes is increasingly used. The antibacterial activity of α-mangostin (AMT) alone or in combination with ceftazidime (CTZ) was investigated against ceftazidime-resistant A. baumannii DMST 45378 (CRAB). Initial screening showed that A. baumannii strains possessed AmpC β-lactamase (AmpC), Extended-Spectrum Beta-Lactamase (ESBL) and metallo-β-lactamases (MBL). Minimum inhibitory concentrations (MICs) of >800 μg ml(-1) against individual antibiotics...
August 11, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28797330/evolving-beta-lactamase-epidemiology-in-enterobacteriaceae-from-italian-nationwide-surveillance-october-2013-kpc-carbapenemase-spreading-among-outpatients
#5
Tommaso Giani, Alberto Antonelli, Mariasofia Caltagirone, Carola Mauri, Jessica Nicchi, Fabio Arena, Elisabetta Nucleo, Silvia Bracco, Annalisa Pantosti, Francesco Luzzaro, Laura Pagani, Gian Maria Rossolini
Extended-spectrum beta-lactamases (ESBLs), AmpC-type beta-lactamases (ACBLs) and carbapenemases are among the most important resistance mechanisms in Enterobacteriaceae. This study investigated the presence of these resistance mechanisms in consecutive non-replicate isolates of Escherichia coli (n = 2,352), Klebsiella pneumoniae (n = 697), and Proteus mirabilis (n = 275) from an Italian nationwide cross-sectional survey carried out in October 2013. Overall, 15.3% of isolates were non-susceptible to extended-spectrum cephalosporins but susceptible to carbapenems (ESCR-carbaS), while 4...
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28768448/resistance-phenotypes-and-susceptibility-of-contemporary-serratia-isolates-in-the-university-hospital-of-crete-greece
#6
George Samonis, Konstantinos Z Vardakas, Sofia Maraki, Petroula Stamouli, Viktoria-Eirini Mavromanolaki, Diamantis P Kofteridis, Matthew E Falagas
OBJECTIVE: To study changes in the susceptibility of Serratia spp. in Crete, Greece (2010-2015). METHODS: Non-duplicate isolates were examined using automated systems. Phenotypic confirmatory tests were applied. RESULTS: Three hundred and seventy-eight Serratia spp. were analyzed. Serratia marcescens (88.3%) was the predominant species. Fluoroquinolones (97.9%), carbapenems (97.4%) and fosfomycin (97.4%) were the most active followed by amikacin (95...
August 2, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28756823/determination-of-carbapenem-resistance-mechanism-in-clinical-isolates-of-pseudomonas-aeruginosa-isolated-from-burn-patients-in-tehran-iran
#7
Akbar Mirsalehian, Davood Kalantar-Neyestanaki, Morovat Taherikalani, Fereshteh Jabalameli, Mohammad Emaneini
Carbapenems are the most important therapeutic options that effect against serious infections caused by multidrug resistant Pseudomonas aeruginosa (MDR-PA) isolates. Carbapenems resistant isolates of P. aeruginosa are increasing worldwide. The aim of this study was to determine the carbapenem resistance mechanisms in clinical P. aeruginosa isolates from burn patients, in Tehran, Iran. A total of 53 non-duplicated isolates of carbapenem-resistant P. aeruginosa were collected from burn patients. The presence of carbapenemase genes were determined by PCR...
September 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/28754148/nosocomial-bacterial-infections-and-their-antimicrobial-susceptibility-patterns-among-patients-in-ugandan-intensive-care-units-a-cross-sectional-study
#8
Peter Agaba, Janat Tumukunde, J V B Tindimwebwa, Arthur Kwizera
BACKGROUND: The intensive care unit (ICU) admits critically ill patients requiring advanced airway, respiratory, cardiac and renal support. Despite the highly-specialized interventions, the mortality and morbidity is still high due to a number of reasons including nosocomial infections, which are the most likely complications in hospitalized patients with the rates being highest among ICU patients. METHODS: In this cross-sectional study of 111 adult patients admitted to 2 of the ICUs in Uganda, we set out to describe the commonest bacterial infections, their antimicrobial susceptibility patterns and factors associated with development of a nosocomial infection...
July 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28751669/in-vivo-loss-of-carbapenem-resistance-by-extensively-drug-resistant-klebsiella-pneumoniae-during-treatment-via-porin-expression-modification
#9
Suzanne Bialek-Davenet, Noémie Mayer, Julia Vergalli, Marion Duprilot, Sylvain Brisse, Jean-Marie Pagès, Marie-Hélène Nicolas-Chanoine
Klebsiella pneumoniae, an Enterobacteriaceae that mostly causes hospital-acquired infections, belongs to the recently published WHO's list of antibiotic-resistant pathogens that pose the greatest threat to human health. Indeed, K. pneumoniae is the enterobacterial species most concerned by both resistance to extended-spectrum cephalosporins, due to extended-spectrum β-lactamase (ESBL) production, and resistance to carbapenems, i.e. the β-lactams with the broadest activity. Carbapenem resistance is related not only to carbapenemase production, but also the production of ESBL or AmpC and the loss of general porins...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28749329/in-vitro-efficacy-of-16-antimicrobial-drugs-against-a-large-collection-of-%C3%AE-lactamase-producing-isolates-of-extraintestinal-pathogenic-escherichia-coli-from-dogs-and-cats
#10
Takae Shimizu, Kazuki Harada, Yuzo Tsuyuki, Yui Kimura, Tadashi Miyamoto, Shingo Hatoya, Yoshiaki Hikasa
PURPOSE: The aim of this study was to assess the in vitro efficacy of candidate antimicrobials against extended-spectrum β-lactamase (ESBL)-producing isolates of extraintestinal pathogenic Escherichia coli (ExPEC) from companion animals. METHODOLOGY: A total of 90 ESBL-producing ExPEC isolates from dogs and cats were tested for susceptibility to 16 antimicrobials with the agar dilution method. We also identified the ESBLs and AmpC β-lactamases of these isolates with PCR and DNA sequencing...
July 28, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28743649/first-report-of-blaoxa-181-mediated-carbapenem-resistance-in-aeromonas-caviae-in-association-with-pkp3-a-threat-for-rapid-dissemination
#11
Shalini Anandan, Radha Gopi, Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Priya Gunasekaran, Kamini Walia, Balaji Veeraraghavan
OBJECTIVES: Aeromonas spp producing carbapenemases is of great concern in health-care settings and also known to acquire clinically relevant resistance genes. In this study, carbapenem non-susceptible Aeromonas isolates were characterized for their molecular mechanism. METHOD: Out of 180 Aeromonas isolates, 10 carbapenem non-susceptible isolates were selected based on their antimicrobial susceptibility profile. Carbapenemase production was investigated using CarbaNP method...
July 22, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28742861/targeting-the-permeability-barrier-and-peptidoglycan-recycling-pathways-to-disarm-pseudomonas-aeruginosa-against-the-innate-immune-system
#12
Gabriel Torrens, Marcelo Pérez-Gallego, Bartolomé Moya, Marta Munar-Bestard, Laura Zamorano, Gabriel Cabot, Jesús Blázquez, Juan A Ayala, Antonio Oliver, Carlos Juan
Antimicrobial resistance is a continuously increasing threat that severely compromises our antibiotic arsenal and causes thousands of deaths due to hospital-acquired infections by pathogens such as Pseudomonas aeruginosa, situation further aggravated by the limited development of new antibiotics. Thus, alternative strategies such as those targeting bacterial resistance mechanisms, virulence or potentiating the activity of our immune system resources are urgently needed. We have recently shown that mutations simultaneously causing the peptidoglycan recycling blockage and the β-lactamase AmpC overexpression impair the virulence of P...
2017: PloS One
https://www.readbyqxmd.com/read/28738348/colistin-resistance-in-kpc-2-and-shv-5-producing-klebsiella-pneumoniae-clinical-isolates-in-bulgaria
#13
Encho Savov, Iva Todorova, Lida Politi, Angelina Trifonova, Maja Borisova, Elena Kioseva, Athanassios Tsakris
BACKGROUND/AIMS: Colistin resistance is increasingly recognized among carbapenemase-producing Klebsiella pneumoniae isolates in several European regions. The current study documents the appearance of colistin resistance among KPC-2 and SHV-5-produning K. pneumoniae strains in Bulgaria. METHODS: Four colistin-resistant K. pneumoniae isolates were recovered from 2 patients hospitalized in the anesthesiology and resuscitation clinic of a tertiary care university hospital in Sofia, Bulgaria...
July 22, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28738272/evolution-of-corresponding-resistance-genes-in-the-water-of-fish-tanks-with-multiple-stresses-of-antibiotics-and-heavy-metals
#14
Xiaolin He, Yanbin Xu, Jinliang Chen, Jiayin Ling, Yafei Li, Lu Huang, Xiao Zhou, Li Zheng, Guangyan Xie
Abuse of antibiotics and heavy metals in aquaculture has been widely concerned and might aggravate the spread of resistance genes in environment. To investigate the occurrence and proliferation of antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs), three commonly used antibiotics (tetracycline, sulfanilamide, cefotaxime) and two heavy metals (Zn and Cu) were designed to add individually or jointly in nine fish tanks including five individual exposure tanks of tetracycline (tet), sulfanilamide (sul), cefotaxime (cef), Cu, Zn and four combination exposure tanks of tetracycline + sulfanilamide (tet + sul), tetracycline + sulfanilamide + cefotaxime (tet + sul + cef), tetracycline + sulfanilamide + Cu (tet + sul + Cu), tetracycline + sulfanilamide + Zn (tet + sul + Zn) as well as the control during the experiment period of 180 days...
July 19, 2017: Water Research
https://www.readbyqxmd.com/read/28735050/antimicrobial-resistance-profiles-and-genotypes-of-extended-spectrum-%C3%AE-lactamase-and-ampc-%C3%AE-lactamase-producing-klebsiella-pneumoniae-isolated-from-dogs-in-beijing-china
#15
Yanhan Liu, Yonghui Yang, Yanyun Chen, Zhaofei Xia
OBJECTIVES: Klebsiella pneumoniae, which exists in the intestinal and respiratory tracts of humans and animals, is an important conditional pathogen in many animals. The aim of the current study was to investigate the antimicrobial resistance profiles and genotypes of extended-spectrum β-lactamase (ESBL)- and AmpC β-lactamase-producing K. pneumoniae isolated from dogs. METHODS: A total of 285 isolates, collected from faecal and urine samples of diseased dogs in a Veterinary Teaching Hospital in Beijing, were characterised by antimicrobial susceptibility testing and screened for ESBL and AmpC β-lactamase phenotypes...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28732790/performance-of-the-%C3%AE-lacta-test-for-rapid-detection-of-expanded-spectrum-cephalosporin-nonsusceptible-enterobacteriaceae
#16
Georgia Vrioni, Vasiliki Mamali, Olympia Zarkotou, Evaggelia Voulgari, Evaggelia Dimitroulia, Katerina Themeli-Digalaki, Spyros Pournaras, Athanassios Tsakris
OBJECTIVES: To study the performance of the rapid chromogenic βLACTA test for the rapid detection of expanded-spectrum cephalosporin (ESC) nonsusceptibility among Enterobacteriaceae, in a region endemic for potent β-lactamases. METHODS: The βLACTA test was applied prospectively on 235 consecutive Enterobacteriaceae clinical isolates and163 previously characterized ESC-nonsusceptible Enterobacteriaceae producing a range of β-lactamases. RESULTS: βLACTA exhibited excellent sensitivity (96...
July 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28728058/high-prevalence-of-esbls-in-retail-chicken-meat-despite-reduced-use-of-antimicrobials-in-chicken-production-france
#17
Tiago Casella, Mara Correa Lelles Nogueira, Estelle Saras, Marisa Haenni, Jean-Yves Madec
Extended-spectrum cephalosporins (ESCs) are critically important antibiotics for humans and their use in animals poses a potential threat for public health. Chicken represents an increasing part of the human diet and has also been regarded as a source of ESC-resistant Enterobacteriaceae because of the worldwide off-label use of ceftiofur, a broad-spectrum cephalosporin. Thus, numerous studies pointed out chicken as a reservoir of ESBL/pAmpC genes, plasmids and/or clones at risk for humans. In France, late 2011, strong political pressure led to a drastic reduction of ceftiofur use and all other antibiotics in chicken production...
July 10, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28718958/multiplex-pcr-scheme-for-variant-plasmid-mediated-class-c-%C3%AE-lactamase-typing
#18
Le Van Chuong, Virapong Prachayasittikul, Chartchalerm Isarankura Na Ayudhya, Ratana Lawung
BACKGROUND: An increasing of prevalence and diversification of plasmid-mediated AmpC (pAmpC) has been emerged worldwide. The incidence of pAmpC resulted in increasing β-lactamase production and conferred resistance to almost all β-lactam antibiotics excluding carbapenems. The lack of standard method for pAmpC identification and classification exert a challenge in epidemiological surveillance and infection control practices. METHODS: A robust, single tube multiplex PCR has been developed to classify six different pAmpC groups including CIT (CMY-2 like, LAT and CFE), ECB (ACT, MIR), MOX & CMY-1 like, DHA, ACC, and FOX...
July 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28711559/outbreak-of-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae-in-tunisia
#19
Wejdène Mansour, Marisa Haenni, Estelle Saras, Raoudha Grami, Yosra Mani, Anis Ben Haj Khalifa, Souhail El Atrouss, Mohamed Kheder, Mohamed Fekih Hassen, Noureddine Boujâafar, Olfa Bouallegue, Jean-Yves Madec
OBJECTIVES: Mechanisms of colistin and carbapenem resistance among a collection of Klebsiella pneumoniae isolates recovered in a university hospital in Tunisia were studied. METHODS: In vitro antimicrobial susceptibility testing, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and PCR-based replicon typing (PBRT) were performed. Extended-spectrum β-lactamases (ESBLs), carbapenemases, AmpC-type enzymes and mgrB genes were detected by PCR and sequencing...
July 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28685856/the-performance-of-a-resazurin-chromogenic-agar-plate-with-a-combined-disc-method-for-rapid-screening-of-extended-spectrum-%C3%AE-lactamases-ampc-%C3%AE-lactamases-and-co-%C3%AE-lactamases-in-enterobacteriaceae
#20
Yothin Teethaisong, Katie Evans, Ismini Nakouti, Kanokwan Tiamyom, James R Ketudat-Cairns, Glyn Hobbs, Griangsak Eumkeb
A promising means of rapid screening of extended-spectrum-β-lactamase (ESBL), AmpC β-lactamase, and co-production of ESBL and AmpC that combines resazurin chromogenic agar (RCA) with a combined disc method is here reported. Cefpodoxime (CPD) discs with and without clavulanic acid (CA), cloxacillin (CX) and CA+CX were evaluated against 86 molecularly confirmed β-lactamase-producing Enterobacteriaceae, including 15 ESBLs, 32 AmpCs, nine co-producers of ESBL and AmpC and 30 carbapenemase producers. The CA and CX synergy test successfully detected all ESBL producers (100% sensitivity and 98...
August 2017: Microbiology and Immunology
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