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History of the rheumatology

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https://www.readbyqxmd.com/read/29191375/rheumatologic-symptoms-in-oncologic-patients-on-pd-1-inhibitors
#1
Wilson F Kuswanto, Lindsey A MacFarlane, Lydia Gedmintas, Alexandra Mulloy, Toni K Choueiri, Bonnie L Bermas
OBJECTIVE: Immune checkpoint inhibitors are effective cancer therapies that have been associated with immune-related adverse events (irAEs). Recent reports of irAEs describe symptoms resembling classic rheumatologic syndromes, most notably associated with cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor blockade. Though cases have been described, there are fewer reports of rheumatologic disease associated with programmed cell death protein-1 (PD-1) inhibitors. Here, we describe a series of four patients presenting to the Brigham and Women's Hospital (BWH) Arthritis Center with de novo polymyalgia rheumatica (PMR)-type conditions and/or peripheral synovitis after treatment with PD-1/PD-Ligand 1 (PD-L1) pathway inhibitors...
October 31, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29145680/-a-rare-differential-diagnosis-of-chronic-cough
#2
Michael Dicker, Tino Schneider, Johannes von Kempis, Markus Diethelm
History and admission findings We report on a 62-year-old male patient with dry cough for 3 months, constitutional symptoms and elevated inflammatory markers. Investigations Despite extensive diagnostics no infectious, malignant or rheumatologic disease could be found. Bronchoscopy with bronchoalveolar lavage showed lymphocytosis. 18-FDG-PET/CT demonstrated increased metabolic activity of the aorta and its primary branches. Diagnosis, treatment and course We diagnosed large vessel vasculitis consistent to a subtype of giant cell arteritis (GCA) without cranial manifestation...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29128948/a-dramatic-case-of-odynophagia
#3
B Sopeña, J Limeres, L García-Caballero, M Diniz-Freitas, J Seoane, P Diz
We report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. The severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ENT, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). During this time, the patient received central parenteral nutrition with an episode of catheter-related septicemia, and he came to require psychiatric assistance for autolytic ideation...
November 11, 2017: Dysphagia
https://www.readbyqxmd.com/read/29116441/validation-of-the-toronto-psoriatic-arthritis-screen-ii-topas-ii-questionnaire-in-a-turkish-population
#4
Mehmet Tuncay Duruöz, Canan Şanal Toprak, Fırat Ulutatar
OBJECTIVE: To evaluate the TOPAS II questionnaire validation in a Turkish population. METHODS: The Turkish translation of ToPAS II was sent to us by the developer authors of the original index. Subjects were recruited from dermatology, physical medicine and rehabilitation, and rheumatology outpatient clinics. All patients' demographic parameters and ToPAS II questionnaire results were recorded. After patients completed the questionnaire they were assessed by a rheumatologist according to a standard protocol which includes a complete history, detailed physical examination, laboratory tests and CASPAR criteria...
November 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29049200/subclinical-atherosclerosis-and-history-of-cardiovascular-events-in-italian-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-multicenter-girrcs-gruppo-italiano-di-ricerca-in-reumatologia-clinica-e-sperimentale-study
#5
MULTICENTER STUDY
Piero Ruscitti, Domenico Paolo Emanuele Margiotta, Federica Macaluso, Daniela Iacono, Francesca D'Onofrio, Giacomo Emmi, Fabiola Atzeni, Marcella Prete, Federico Perosa, Piercarlo Sarzi-Puttini, Lorenzo Emmi, Francesco Paolo Cantatore, Giovanni Triolo, Antonella Afeltra, Roberto Giacomelli, Gabriele Valentini
Several studies have pointed out a significant association between rheumatoid arthritis (RA) and accelerated atherosclerosis. At the best of our knowledge, no such study has been carried out in a large Italian series and, in this study, we aimed to investigate the prevalence of both subclinical atherosclerosis and history of cardiovascular events (CVEs), in patients consecutively admitted from January 1, 2015 to December 31, 2015 to Rheumatology Units throughout the whole Italy.Centers members of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) were invited to enrol patients consecutively admitted from January 1, 2015 to December 31, 2015 and satisfying American College of Rheumatology/ European League Against Rheumatism criteria for RA and to investigate each of them for: traditional cardiovascular risk factors: sex, age, smoking habit, total cholesterol, triglycerides, glycaemia, high blood pressure, metabolic syndrome (MS), type 2 diabetes (T2D); RA features: disease duration as assessed from the first symptom, disease activity as evaluated by DAS28, radiographic damage as assessed by hands and feet x-ray, and previous joint surgery; prevalence of both subclinical atherosclerosis and history of CVEs...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048419/a-cross-sectional-quantitative-analysis-of-the-natural-history-of-farber-disease-an-ultra-orphan-condition-with-rheumatologic-and-neurological-cardinal-disease-features
#6
Matthias Zielonka, Sven F Garbade, Stefan Kölker, Georg F Hoffmann, Markus Ries
PurposeFarber disease (OMIM 22800) is an ultrarare progressive multisystemic neurodevelopmental storage disorder caused by a deficiency of the lysosomal enzyme acid ceramidase (AC). Hard clinical end points for future clinical trials remain to be defined.MethodsWe quantitatively analyzed published cases with Farber disease (N = 96). The main outcome variables were survival and diagnostic delay. As a potential predictor of survival, the influence of residual AC enzyme activity was investigated. The analysis was performed in compliance with STROBE criteria...
October 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29042750/current-perspective-on-rituximab-in-rheumatic-diseases
#7
REVIEW
Tommaso Schioppo, Francesca Ingegnoli
The steadily increasing knowledge regarding pathogenetic mechanisms in autoimmune rheumatic diseases has paved the way to different therapeutic approaches. In particular, the market entry of biologics has dramatically modified the natural history of rheumatic chronic inflammatory diseases with a meaningful impact on patients' quality of life. Among the wide spectrum of available biological treatments, rituximab (RTX), first used in the treatment of non-Hodgkin's lymphoma, was later approved for rheumatoid arthritis and anti-neutrophil cytoplasmic antibodies-associated vasculitis...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29037524/t-regulatory-cells-triumph-of-perseverance-the-crafoord-prize-for-polyarthritis-in-2017
#8
REVIEW
Frank A Wollheim
The Crafoord Prize in Polyarthritis ranks as one of the most prestigious prizes and can be awarded only if the Royal Swedish Academy of Sciences decides the likelihood of prize worthy progress in the field, and at most every 4th year. This has happened only four times since 1982. This year the 5th Laureates were Shimon Sakaguchi, Fred Ramsdell, and Alexander Rudensky with the motivation "for their discoveries relating to regulatory T cells, which counteract harmful immune reactions in arthritis and other autoimmune diseases"...
September 6, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29021953/bilateral-lung-disease-extensive-and-diffuse-diagnosis-of-pulmonary-alveolar-proteinosis-by-bronchoscopic-cryobiopsy
#9
Sebastián Gando, Roberto Duré, Damián Violi, Bibiana Vazquez, Gonzalo Labarca, Sebastián Fernandez-Bussy
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the intra-alveolar accumulation of a proteinaceous phospholipid-laden material called surfactant. Clinically, this disease should be suspected with respiratory failure in association with a crazy paving pattern on high-resolution chest computed tomography. We report a 24-year-old gentleman who was referred to us for a history of respiratory failure, treatment with invasive ventilation and tracheostomy. His blood exams and biochemistry were normal...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29020765/insulin-resistance-is-an-independent-predictor-of-erectile-dysfunction-in-patients-with-gout
#10
Ji Hun Kim, Min Kyung Chung, Jin Young Kang, Jung Hee Koh, Jennifer Lee, Seung-Ki Kwok, Ji Hyeon Ju, Sung-Hwan Park
Background/Aims: Gout is associated with metabolic disorders that are important risk factors for cardiovascular disease and erectile dysfunction (ED). We aimed to identify independent predictors of ED in patients with gout. Methods: From August 2014 to August 2015, male outpatients who were being treated for gout in our rheumatology clinic and healthy males without any history of inflammatory disease (control group) were studied. ED was assessed in participants using the five-item version of the International Index of Erectile Function questionnaire...
October 12, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28992369/predictive-value-of-pre-operative-inflammation-based-prognostic-scores-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-monocyte-to-eosinophil-ratio-in-testicular-sperm-extraction-a-pilot-study
#11
C Yucel, M Z Keskin, O Cakmak, B Ergani, C Kose, O Celik, E Islamoglu, M Ucar, G Koc, Z Kozacioglu
To investigate the ability of some hematologic prognostic scores demonstrating inflammation in predicting sperm presence in testicular sperm extraction (TESE). We retrospectively investigated the medical data of 430 patients with the diagnosis of non-obstruc tive azoospermia (NOA) who had undergone TESE operation consecutively in our institution between the dates of January 2009 and February 2017. In all, 352 patients with the diagnosis of NOA, with bilaterally palpable vas deferens, who had undergone TESE for the first time, were included in the study...
October 9, 2017: Andrology
https://www.readbyqxmd.com/read/28990976/orbital-inflammation-as-a-presenting-sign-for-crest-syndrome
#12
Shirin W Hamed-Azzam, David P D'Cruz, David H Verity
A 61-year-old male was referred with a week's history of a painful and swollen left eye. Examination revealed normal visual acuities, left proptosis and global restriction of ocular ductions, and subretinal fluid at the macula. CT imaging confirmed thickening of the posterior scleral coat, with an associated choroidal effusion. Serology revealed positive antinuclear antibodies with a centromere staining pattern; subsequent rheumatology review revealed extensive telangiectasia with digital ulceration in both hands, and a diagnosis of limited cutaneous systemic sclerosis was made...
September 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28977549/2016-acr-eular-adult-dermatomyositis-and-polymyositis-and-juvenile-dermatomyositis-response-criteria-methodological-aspects
#13
Lisa G Rider, Nicolino Ruperto, Angela Pistorio, Brian Erman, Nastaran Bayat, Peter A Lachenbruch, Howard Rockette, Brian M Feldman, Adam M Huber, Paul Hansen, Chester V Oddis, Ingrid E Lundberg, Anthony A Amato, Hector Chinoy, Robert G Cooper, Lorinda Chung, Katalin Danko, David Fiorentino, Ignacio García-De la Torre, Ann M Reed, Yeong Wook Song, Rolando Cimaz, Rubén J Cuttica, Clarissa A Pilkington, Alberto Martini, Janjaap van der Net, Susan Maillard, Frederick W Miller, Jiri Vencovsky, Rohit Aggarwal
Objective: The objective was to describe the methodology used to develop new response criteria for adult DM/PM and JDM. Methods: Patient profiles from prospective natural history data and clinical trials were rated by myositis specialists to develop consensus gold-standard ratings of minimal, moderate and major improvement. Experts completed a survey regarding clinically meaningful improvement in the core set measures (CSM) and a conjoint-analysis survey (using 1000Minds software) to derive relative weights of CSM and candidate definitions...
November 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28938508/-angina-pectoris-in-a-young-woman-with-lupus-erythematosus
#14
Simon Braumann, Malte P Bartram, Roman Pfister, Guido Michels
History and clinical findings We present a 31-year old woman with a 6-year history of cutaneous lupus erythematosus (CLE) who presented to the emergency room with typical chest pain. ECG and transthoracic echocardiography were normal. Her working diagnosis of pericarditis was made due to systemic progression of her lupus erythematosus (LE). Treatment with NSAIDs was initiated and her immunosuppressive regimen intensified. The patient was discharged after resolution of her symptoms. A week later, the patient was seen at the rheumatology clinic with recurrence and aggravation of her symptoms...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28917219/reuma-pt-contribution-to-the-knowledge-of-immune-mediated-systemic-rheumatic-diseases
#15
Maria José Santos, Helena Canhão, Ana Filipa Mourão, Filipa Oliveira Ramos, Cristina Ponte, Cátia Duarte, Anabela Barcelos, Fernando Martins, José António Melo Gomes
Patient registries are key instruments aimed at a better understanding of the natural history of diseases, at assessing the effectiveness of therapeutic interventions, as well as identifying rare events or outcomes that are not captured in clinical trials. However, the potential of registries goes far beyond these aspects. For example, registries promote the standardization of clinical practice, can also provide information on domains that are not routinely collected in clinical practice and can support decision-making...
July 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28882616/screening-of-inflammatory-bowel-disease-and-spondyloarthritis-for-referring-patients-between-rheumatology-and-gastroenterology
#16
Jesús Sanz Sanz, Xavier Juanola Roura, Daniel Seoane-Mato, Miguel Montoro, Fernando Gomollón
OBJECTIVE: To define clinical screening criteria for spondyloarthritis (SpA) in patients with inflammatory bowel disease (IBD) and vice versa, which can be used as a reference for referring them to the rheumatology or gastroenterology service. METHOD: Systematic literature review and a two-round Delphi method. The scientific committee and the expert panel were comprised of 2 rheumatologists and 2 gastroenterologists, and 7 rheumatologists and 7 gastroenterologists, respectively...
September 4, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28832223/local-bone-loss-in-patients-with-anti-citrullinated-peptide-antibody-and-arthralgia-evaluated-with-high-resolution-peripheral-quantitative-computed-tomography
#17
K K Keller, J S Thomsen, K Stengaard-Pedersen, A W Nielsen, B Schiøttz-Christensen, L Svendsen, M Graakjær, P M Petersen, B Unger, S G Kjær, B L Langdahl, E M Hauge
OBJECTIVE: To investigate bone changes in the metacarpophalangeal (MCP) joints of anti-citrullinated peptide antibody (ACPA)-positive patients with arthralgia, but not arthritis, compared to healthy controls. METHOD: Using a cross-sectional study design, patients were recruited from hospitals and private care rheumatologists, and controls from a test subject website. All subjects underwent medical history interview, clinical examination, and biochemical screening including ACPA...
August 23, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28795234/demographic-and-clinical-characteristics-of-patients-with-serum-sickness-like-reaction
#18
Alaaddin Yorulmaz, Fatih Akın, Ahmet Sert, Mehmet Akif Ağır, Rıza Yılmaz, Şükrü Arslan
In this study, we aimed to review the demographic, clinical, and laboratory characteristics of patients who were followed up and treated with the diagnosis of serum sickness-like reactions (SSLR) in our pediatric rheumatology clinic retrospectively and emphasize the importance of early diagnosis and treatment. The files of 29 patients who were hospitalized in the pediatric rheumatology clinic between September 2016 and March 2017 with the diagnosis of type 3 hypersensitivity reaction were reviewed retrospectively...
August 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28792612/problems-and-solutions-for-patients-with-fibromyalgia-building-new-helping-relationships
#19
Pilar Montesó-Curto, Montserrat García-Martinez, Sara Romaguera, María Luisa Mateu, María Teresa Cubí-Guillén, Lidia Sarrió-Colas, Anna Núria Llàdser, Stephen Bradley, María Luisa Panisello-Chavarria
AIM: To identify the main biological, psychological and sociological problems and potential solutions for patients diagnosed with fibromyalgia by use of Group Problem-Solving Therapy. BACKGROUND: Group Problem-Solving Therapy is a technique for identifying and solving problems, increasing assertiveness, self-esteem and eliminating negative thoughts. DESIGN: Qualitative phenomenological interpretive design: Group Problem-Solving Therapy sessions conducted with patients suffering fibromyalgia were studied; participants recruited via the Rheumatology Department at a general hospital and associations in Catalonia, Spain with sessions conducted in nearby university setting...
August 9, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28791449/incidence-of-inflammatory-joint-diseases-in-finland-results-from-a-population-based-epidemiological-study
#20
A Kononoff, L Arstila, P Pussinen, H Kautiainen, P Elfving, E Savolainen, H Niinisalo, J Rutanen, O Marjoniemi, O Kaipiainen-Seppänen
The objective of the study was to assess the incidence of inflammatory joint diseases and possible environmental factors contributing to their occurrence in a defined population in Finland. All rheumatologists practising in the Northern Savo rheumatological outpatient departments collected data on their newly diagnosed patients with an inflammatory joint disease in 2010. Antibodies to Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) were determined from patients with various arthritides...
October 2017: Rheumatology International
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