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Non-regenerative anemia

W Iverson, E Straley, S Oldham, J Rojko, S Turman, Y Wang
Mice transgenic for human CD19 have been an important animal model to help understand the role of this molecule in B lymphocyte function. Previously, no lifetime studies had been performed to understand the effects of this CD19 over expression on the survival or spontaneous pathology within the C57BL/6J background strain. We conducted a lifetime study with interim sacrifices to understand the transgenic effects on clinical signs, body weight, survival, and spontaneous pathology. Blood and urine samples were collected from select animals at various time points during the study for measurement of clinical pathology parameters and groups of animals were euthanized and examined at predetermined intervals...
June 2017: Transgenic Research
José M Martínez de Zabarte Fernández, Carmen Rodríguez-Vigil Iturrate, Cristina Martínez Faci, Inmaculada García Jiménez, Laura Murillo Sanjuan, Ascensión Muñoz Mellado
Anemia is very common in infants. Although its causes are usually not severe and treatable, proper etiologic diagnosis should be established. When anemia is non-regenerative, it can be caused by aplastic anemia, myelodysplastic syndrome, bone marrow infiltration or hematopoietic factors deficiencies. Another possible cause is Pearson's syndrome, a rare mitochondrial disease that causes non-regenerative anemia associated with other cytopenias, pancreatic insufficiency, lactic acidosis and great variability in clinical presentation conditioned by heteroplasmy...
February 1, 2017: Archivos Argentinos de Pediatría
R B P Torrecilha, Y T Utsunomiya, A M Bosco, B F Almeida, P P Pereira, L G Narciso, D C M Pereira, L Baptistiolli, L Calvo-Bado, O Courtenay, C M Nunes, P C Ciarlini
Intensity of peripheral parasite infection has an important role in the transmission of Leishmania spp. from one host to another. As parasite load quantification is still an expensive procedure to be used routinely in epidemiological surveillance, the use of surrogate predictors may be an important asset in the identification of dogs with high transmitting ability. The present study examined whether common clinical and laboratory alterations can serve as predictors of peripheral parasitism in dogs naturally infected with Leishmania spp...
September 15, 2016: Preventive Veterinary Medicine
Christopher B Mahony, Richard J Fish, Corentin Pasche, Julien Y Bertrand
In mammals, embryonic hematopoiesis occurs in successive waves, culminating with the emergence of hematopoietic stem cells (HSCs) in the aorta. HSCs first migrate to the fetal liver (FL), where they expand, before they seed the bone marrow niche, where they will sustain hematopoiesis throughout adulthood. In zebrafish, HSCs emerge from the dorsal aorta and colonize the caudal hematopoietic tissue (CHT). Recent studies showed that they interact with endothelial cells (ECs), where they expand, before they reach their ultimate niche, the kidney marrow...
September 8, 2016: Blood
Kosuke Kobayashi, Takako Shimokawa Miyama, Kazuhito Itamoto, Shunsuke Noguchi, Kenji Baba, Takuya Mizuno, Masaru Okuda
A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported...
November 1, 2016: Journal of Veterinary Medical Science
Scott Stokowski, Jeffrey Ruth, Otto Lanz, Vincent Ziglioli
An 11-year-old male German Shepherd dog presented for inappetence and weight loss. Physical examination and initial bloodwork revealed palpable abdominal masses, mild non-regenerative anemia, and thrombocytopenia. Survey radiography and abdominal ultrasonography confirmed the presence of bilateral abdominal masses and lymphadenopathy. Contrast-enhanced computed tomography (CT) was performed in order to further investigate the origin of the intraabdominal masses, confirming two enlarged cryptorchid testes, one of which had an associated CT "whirl sign...
2016: Frontiers in Veterinary Science
Daniela Proverbio, Eva Spada, Roberta Perego, Giada Bagnagatti de Giorgi
Serum hyperviscosity syndrome (HVS) was documented in two dogs with canine leishmaniasis (CanL) and seizures as the major clinical complaint. In both cases, laboratory abnormalities included mild non-regenerative anemia, thrombocytopenia, hypoalbuminemia, hyperproteinemia with monoclonal gammopathy, and marked serum hyperviscosity. CanL was diagnosed using cytology in one case and indirect immunofluorescence assay and conventional polymerase chain reaction in the second. Specific therapy with meglumine antimoniate and allopurinol(c) led to short-term remission in both dogs and normalization of serum viscosity...
March 2016: Journal of the American Animal Hospital Association
Stefanie Nesina, A Katrin Helfer-Hungerbuehler, Barbara Riond, Felicitas S Boretti, Barbara Willi, Marina L Meli, Paula Grest, Regina Hofmann-Lehmann
BACKGROUND: The feline leukemia virus (FeLV) is a gamma-retrovirus of domestic cats that was discovered half a century ago. Cats that are infected with FeLV may develop a progressive infection resulting in persistent viremia, immunodeficiency, tumors, anemia and death. A significant number of cats mount a protective immune response that suppresses viremia; these cats develop a regressive infection characterized by the absence of viral replication and the presence of low levels of proviral DNA...
December 21, 2015: Retrovirology
A Katrin Helfer-Hungerbuehler, Stefan Widmer, Yvonne Kessler, Barbara Riond, Felicitas S Boretti, Paula Grest, Hans Lutz, Regina Hofmann-Lehmann
It is a remarkable feature for a retrovirus that an infection with feline leukemia virus (FeLV) can result in various outcomes. Whereas some cats contain the infection and show a regressive course, others stay viremic and succumb to the infection within a few years. We hypothesized, that differences in the infection outcome might be causally linked to the viral RNA and provirus loads within the host and these loads therefore may give additional insight into the pathogenesis of the virus. Thus, the goals of the present study were to follow-up on experimentally infected cats and investigate tissues from cats with different infection outcomes using sensitive, specific TaqMan real-time PCR and reverse transcriptase (RT)-PCR...
February 2, 2015: Virus Research
Laurane Cottin, Camille Rouvet, Chadi Homedan, Mathieu Conté, Satar Mortaza, Marie-Christine Rousselet, Anne Corby, Maïlys Le Guyader, Marc Zandecki, Pascal Reynier
We describe the case of a 30-year-old patient, suffering from composite S/β + sickle cell disease. He was hospitalized following a vaso-occlusive attack with acute bone pains. Despite an analgesic treatment and transfusion of three units of red blood cells, a non-regenerative anemia appeared within 24 hours. One day later an acute chest syndrome with atelectasis of the left lung and desaturation and multi-organ failure occurred and necessitated the patient's intubation and required him to be placed in an artificial coma...
September 2014: Annales de Biologie Clinique
Erika Carli, Michele Trotta, Eliana Bianchi, Tommaso Furlanello, Marco Caldin, Mario Pietrobelli, Laia Solano-Gallego
Two young brother male free-ranging domestic shorthair cats were evaluated for diarrhea. They presented with intraerythrocytic piroplasms on blood smear evaluation. Only the first cat was anemic (mild non-regenerative anemia). A partial segment of the 18S rRNA was amplified and sequenced, revealing a homology of 99% with Cytauxzoon sp. and of 93% with Cytauxzoon felis. The first cat was treated with doxycycline and imidocarb dipropionate and monitored by serial laboratory exams, resulting negative for Cytauxzoon sp...
2014: Türkiye Parazitolojii Dergisi
Laurent Chiche, Julien Mancini, Jean-Benoît Arlet
BACKGROUND: Cobalamin (Cb) blood levels are frequently measured among inpatients, but the relevance of Cb determination has not been correctly assessed in this clinical setting. PURPOSE: We aimed to prospectively evaluate current indications compared to traditional guidelines for assessing Cb blood levels among inpatients from internal medicine departments. STUDY DESIGN: This study was conducted in French departments of internal medicine between 2008 and 2009...
October 2013: Postgraduate Medical Journal
Valentina Foglia Manzillo, Trentina Di Muccio, Sivia Cappiello, Aldo Scalone, Rosa Paparcone, Eleonora Fiorentino, Manuela Gizzarelli, Marina Gramiccia, Luigi Gradoni, Gaetano Oliva
The incidence of clinical and clinicopathological signs associated with the progression of infection was evaluated prospectively in 329 naïve young dogs exposed to Leishmania infantum transmission and examined periodically during 22 months (M). The dogs were part of Leishmania vaccine investigations performed under natural conditions. Vaccinated groups were considered in the evaluation when the vaccine resulted non-protective and the appearance and progression of signs did not differ statistically from controls at each time point, otherwise only control groups were included...
2013: PLoS Neglected Tropical Diseases
Minerva Mercado-Feliciano, Michelle C Cora, Kristine L Witt, Courtney A Granville, Milton R Hejtmancik, Laurene Fomby, Katherine A Knostman, Michael J Ryan, Retha Newbold, Cynthia Smith, Paul M Foster, Molly K Vallant, Matthew D Stout
Black cohosh rhizome (Actaea racemosa) is used as a remedy for pain and gynecological ailments; modern preparations are commonly sold as ethanolic extracts available as dietary supplements. Black cohosh was nominated to the National Toxicology Program (NTP) for toxicity testing due to its widespread use and lack of safety data. Several commercially available black cohosh extracts (BCE) were characterized by the NTP, and one with chemical composition closest to formulations available to consumers was used for all studies...
September 1, 2012: Toxicology and Applied Pharmacology
Kenji Baba, Kazuhito Itamoto, Akiteru Amimoto, Kozue Kitagawa, Hiroko Hiraoka, Takuya Mizuno, Hiroshi Sato, Masaru Okuda
Two dogs, emigrated from Zambia and China to Japan, were diagnosed with Ehrlichia canis infection. Both cases had thrombocytopenia, non-regenerative anemia, and hypergloblinemia with polyclonal gammopathy. Case 1 had ataxia of the hind limbs. Severe meningitis was revealed by magnetic resonance imaging examination. Intracytoplasmic inclusions were observed in mononuclear cells of cerebrospinal fluid. Case 2 had a history of bilateral epistaxis, and severe pancytopenia was noticed in complete blood count. Diagnosis was finally achieved by nested polymerase chain reaction and sequence analysis...
June 2012: Journal of Veterinary Medical Science
A El Khattabi, Y Sekkach, H Seddik, H Zahid
Iron deficiency anemia as a hematologic complication of the antithyroid medication (ATS) that has not been already described in the literature. We report on two exceptional cases: the first case concerns a 24 years old man admitted for an anemic syndrome. He was treated with carbimazole for Graves' disease. The blood count showed a non-regenerative microcytic anemia. Serum ferritin was severely decreased. The etiologic searching for bleeding, hemolysis, malabsorption or iron deficiency was negative. Treatment with iron salts was introduced without any real improvement...
November 2011: Annales Pharmaceutiques Françaises
Kim E Jie, Karien van der Putten, Marloes W T Bergevoet, Pieter A Doevendans, Carlo A J M Gaillard, Branko Braam, Marianne C Verhaar
OBJECTIVE: Patients with cardiorenal syndrome (CRS) have high cardiovascular morbidity. Endothelial progenitor cells (EPC) constitute an endogenous vascular repairsystem, protecting against atherosclerosis development. Erythropoietin (EPO) treatment may have beneficial effects by mobilizing EPC from the bonemarrow. Our objective is to determine EPC levels and effects of EPO therapy on EPC levels in CRS patients. DESIGN: Open-label randomized trial. SETTING: Part of the EPOCARES-trial, conducted in Utrecht (Netherlands)...
January 2011: Heart: Official Journal of the British Cardiac Society
Aleksandro Schafer Da Silva, Márcio Machado Costa, Patrícia Wolkmer, Régis Adriel Zanette, Luciana Faccio, Lucas Trevisan Gressler, Tagor Eduardo Andreolla Dorneles, Janio Morais Santurio, Sonia Terezinha dos Anjos Lopes, Silvia Gonzalez Monteiro
This study aimed at evaluating hemogram and erythropoietic changes in cats experimentally infected with Trypanosoma evansi. Thirteen adult female non-breeding Felix catus were separated into two groups: seven animals were infected with 10(8) trypomastigotes each, and six animals were used as negative controls. Animals were kept in air-conditioned rooms and blood smears were performed daily for 49 days. Blood samples were collected from the jugular vein at days 0, 7, 21, 35 and 49 and stored in blood-collecting tubes containing anticoagulant...
September 2009: Experimental Parasitology
Rafał R Starzyński, François Canonne-Hergaux, Alexandra Willemetz, Mikołaj A Gralak, Jarosław Woliński, Agnieszka Styś, Jarosław Olszak, Paweł Lipiński
The continuous recycling of haem iron following phagocytosis and catabolism of senescent and damaged red blood cells by macrophages is a crucial process in the maintenance of systemic iron homoeostasis. However, little is known about macrophage iron handling in haemolytic states resulting from a deficiency in antioxidant defences. Our observations indicate that the recently described chronic, but moderate regenerative, haemolytic anaemia of aged SOD1 (superoxide dismutase 1)-knockout mice is associated with red blood cell modifications and sensitivity to both intra- and extra-vascular haemolysis...
May 27, 2009: Biochemical Journal
E Carli, S Tasca, M Trotta, T Furlanello, M Caldin, L Solano-Gallego
The aim of this study was to examine by means of flow cytometry immunophenotyping (FCI) if sick dogs infected with Babesia canis canis (B. c. canis) or Babesia canis vogeli (B. c. vogeli) had anti-erythrocyte membrane binding IgG and/or IgM at the time of diagnosis. Diagnosis of Babesia infection was assessed by blood smear and by PCR-restriction fragment length polymorphism analysis in 30 sick dogs. Signalment, clinical history, physical examination and laboratory tests of B. c. canis (n=24) and of B. c. vogeli (n=6) infected dogs were studied...
May 26, 2009: Veterinary Parasitology
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