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https://www.readbyqxmd.com/read/29141314/-a-novel-compound-heterozygous-mutation-in-abca3-gene-in-a-child-with-diffuse-parenchymal-lung-disease
#1
Y M Bao, X L Liu, X L Liu, J H Chen, Y J Zheng
Objective: To summarize the clinical characteristics of the diffuse parenchymal lung diseases in a child caused by a novel compound heterozygous ABCA3 mutation and explore the association between the phenotype and ABCA3 mutation. Method: The clinical material of a patient diagnosed with diffuse parenchymal lung disease with ABCA3 mutation in December 2016 in Shenzhen Children's Hospital was analyzed. The information about ABCA3 gene mutation updated before April, 2017 was searched and collected from the gene databases (including 1000Genomes, HGMD, EXAC) and the literatures (including Wanfang Chinese database and Pubmed)...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29136066/unsuspected-lymphomatoid-granulomatosis-in-a-patient-with-antisynthetase-syndrome
#2
Stephanie L Skala, Alexandra C Hristov, Johann E Gudjonsson, May P Chan
Clinical diagnosis of lymphomatoid granulomatosis (LYG) often is difficult, especially in patients with multiple comorbidities. We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. Her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. Computed tomography showed ground-glass opacities and nodular infiltrates in all lung lobes, raising concern for radiation pneumonitis and drug toxicity...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29135404/-bilateral-total-lung-lavage-in-a-patient-with-pulmonary-alveolar-proteinosis
#3
Müge Erbay, Yılmaz Bülbül, Funda Öztuna, Mehmet Kılıç, Neslihan Özçelik, Şafak Ersöz
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar accumulation of surfactant composed of proteins and lipids. Three main categories of PAP have been defined depending on the aetiology: primer/idiopathic, neonatal/congenital, secondary and exogenous/environmental exposure. Radiologically diffuse ground glass opacities, interlobular and intralobular septal thickening is seen. Although open lung biopsy is accepted as the gold standard in diagnosis, it can be diagnosed by showing bronchoalveolar lavage (BAL) fluid with a milky appearance and periodic acid-schiff (PAS) positive globules in biopsy with clinical and radiological findings...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29132896/ground-glass-opacity-of-the-lung-the-veil-that-needs-lifting
#4
EDITORIAL
Abbas E Abbas
No abstract text is available yet for this article.
December 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29127699/the-maximum-standardized-uptake-value-of-preoperative-positron-emission-tomography-computed-tomography-in-lung-adenocarcinoma-with-a-ground-glass-opacity-component-of-less-than-30%C3%A2-mm
#5
Bong Y Son, Sukki Cho, Sung W Yum, Kwhanmien Kim, Sanghoon Jheon
BACKGROUND AND OBJECTIVES: This study evaluated the relationship between the maximum standardized uptake value (SUVmax) of preoperative positron emission tomography/computed tomography (PET/CT) and the characteristics of lung adenocarcinoma featuring ground-glass opacity nodules (GGN). METHODS: The association of the SUVmax of preoperative PET/CT with ground-glass opacity (GGO) proportion on CT, subtypes of adenocarcinoma (minimally invasive adenocarcinoma, invasive adenocarcinoma), predominant types of invasive adenocarcinoma, and size of the total and invasive components of pathology were evaluated in 190 patients who underwent resection for lung adenocarcinoma featuring GGN...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29124658/atypical-hrct-manifestations-of-pulmonary-sarcoidosis
#6
Diletta Cozzi, Elena Bargagli, Alessandro Giuseppe Calabrò, Elena Torricelli, Federico Giannelli, Edoardo Cavigli, Vittorio Miele
PURPOSE: To present our experience of cases of pulmonary sarcoidosis with atypical HRCT patterns found during 2016 focusing on the differential diagnosis to contribute to the difficult role of the radiologist in the disease identification and to help the clinicians to reach the diagnosis. MATERIALS AND METHODS: The HRCT examinations of 47 patients with sarcoidosis were studied retrospectively. All patients had a histopathological confirm of the disease. 29 (61.7%) show a typical pulmonary pattern and 18 (38...
November 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29114418/stop-being-so-sensitive-an-exceptionally-rare-report-of-ustekinumab-induced-sub-acute-hypersensitivity-pneumonitis
#7
Azka Ali, Jason Chertoff, Christopher Harden, Dara Wakefield, James Wynne
Hypersensitivity pneumonitis (HSP) is a rare syndrome characterised by granulomatous inflammatory lung disease due to repeated sensitisation from a specific antigen. We present the case of a 61-year old male veteran with a history of nodular eczema who presented with 2 weeks of progressive dyspnoea on exertion and pleuritic chest pain. The patient was started on ustekinumab 5 weeks prior to presentation. Initial workup revealed ground-glass opacities on computed tomography (CT) scan of the chest. Cardiac workup was unrevealing with a normal myocardial perfusion stress test...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29110852/radiological-classification-of-multiple-lung-cancers-and-the-prognostic-impact-based-on-the-presence-of-a-ground-glass-opacity-component-on-thin-section-computed-tomography
#8
Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
OBJECTIVES: Revised TNM classification has proposed a new clinical classification of lung cancers with multiple pulmonary sites. However, definition of the radiological findings and their prognostic impacts are still controversial. Therefore, we evaluated the prognostic impact of multiple lung cancers based on the radiologic classifications concluded from findings on thin-section computed tomography. METHODS: Among surgically resected 1440 c-stage I lung cancer patients, 246 (17...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29104652/plain-and-contrast-enhanced-chest-computed-tomography-scan-findings-of-pulmonary-cryptococcosis-in-immunocompetent-patients
#9
Rongshui Yang, Yan Yan, Yuhuan Wang, Xiaohuan Liu, Xinhui Su
Pulmonary cryptococcosis is most commonly reported in immunocompromised patients, whereas immunocompetent hosts are rarely affected and may be asymptomatic, resulting in reduced diagnostic performance of computed tomography (CT) imaging. Thus, the aim of the present study was to review the plain and contrast-enhanced chest CT scan findings of primary pulmonary cryptococcosis in immunocompetent patients, with the aim of improving the diagnosis of this type of pulmonary disease. In the present study, a total of 27 immunocompetent patients of clinically confirmed pulmonary cryptococcosis were analyzed retrospectively...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29104200/-usefulness-of-oxidization-regenerated-cellulose-sheets-in-preventing-postoperative-adhesion-confirmed-at-second-surgery-for-lung-cancer
#10
Eiki Mizutani, Kazuki Nakahara, Shigeki Miyanaga, Ayako Seike, Emi Sakai
The patient was a 42-year-old woman who had been found to have a mixed ground glass opacity in the lung on chest computed tomography, and had underwent right S6 segmentectomy. At surgery, the plain between the upper and lower lobe was covered with a regenerative oxidized cellulose membrane. Two years later, multiple small shadows appeared in the remaining right lower lobe and completion right lower lobectomy was performed by thoracoscopy due to the adhesion to the absence of adhesion. Both of the histological examinations confirmed the diagnosis of minimally invasive adenocarcinoma of the lung...
November 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29102950/fibrotic-lung-toxicity-induced-by-hydroxycarbamide
#11
Elena Bargagli, Marco Palazzi, Francesco Perri, Elena Torricelli, Elisabetta Rosi, Alessandra Bindi, Massimo Pistolesi, Luca Voltolini
A patient treated for 4 months with hydroxycarbamide (hydroxyurea) for chronic myelomonocytic leukemia was admitted to hospital for recently developed severe dyspnea and acute respiratory failure. The computed tomographic scan of the chest showed diffuse ground glass opacities, some centrilobular low-density nodules (resembling hypersensitivity pneumonitis-like pattern), and minimal interstitial reticulation of the subpleural region. The analysis of bronchoalveolar lavage fluid excluded infection, as did serological examinations...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29098128/hot-tub-lung-a-diagnostic-challenge
#12
Hassaan Yasin, William E Mangano, Paras Malhotra, Ali Farooq, Hesham Mohamed
Hot tub lung (HTL) is a granulomatous lung disease thought to occur as a result of a hypersensitivity response to non-tuberculous mycobacteria (NTM). Typical radiographic findings are diffuse micronodular and/or ground glass opacities. We report an interesting case of HTL that presented with unique radiographic features, making its diagnosis a predicament. A 56-year-old immunocompetent female with chronic dyspnea and dry cough was found to have subcentimeter cavitary nodules, predominantly in the upper lung zones...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29095306/clinical-features-of-secondary-pulmonary-alveolar-proteinosis-associated-with-myelodysplastic-syndrome-two-case-reports
#13
Yin Liu, Lu Lu Chen, Yu Ying Qiu, Yong Long Xiao, Hou Rong Cai
RATIONALE: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by the abnormal accumulation of alveolar surfactant protein in alveolar spaces. Secondary PAP can result from myelodysplastic syndrome (MDS). PATIENT CONCERNS: But most reports described a single case; here we reported 2 cases of PAP secondary to MDS. One case developed secondary PAP at the same time as MDS, and the other developed during the course of MDS. DIAGNOSES: The diagnosis of PAP was made by bronchoalveolar lavage and based on the identification of periodic acid-Schiff-positive proteinaceous material...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093385/a-case-of-pneumocystis-pneumonia-secondary-to-idiopathic-cd4-t-lymphocytopenia-a-comparison-of-aids-and-non-aids-patients
#14
Kazuki Sone, Hideki Muramatsu, Makoto Nakao, Yusuke Kagawa, Ryota Kurokawa, Hidefumi Sato, Akio Niimi
A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pneumonia (PCP), he was given oral sulfamethoxazole/trimethoprim, to which he responded well. However, seven months later, PCP relapsed. Analyses revealed a low bronchoalveolar lavage fluid CD4/CD8 ratio of 0.04 and CD4+ lymphocytopenia (250/μL)...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29092754/favorable-prognosis-and-high-discrepancy-of-genetic-features-in-surgical-patients-with-multiple-primary-lung-cancers
#15
Kezhong Chen, Wei Chen, Jianqiao Cai, Fan Yang, Feng Lou, Xun Wang, Jingbo Zhang, Mingyu Zhao, Jay Zhang, Jun Wang
OBJECTIVE: Multiple primary lung cancers are detected with increasing frequency, but the ideal strategy for diagnosis and treatment remains disputable. This study evaluated both clinical characteristics and genetic alterations to investigate the appropriate strategy for patients with multiple primary lung cancer. METHODS: A total of 96 patients in our practice were diagnosed with multiple primary lung cancer over 7 years by clinical-pathologic criteria. According to consolidation/tumor ratio, they were classified into 3 groups: group A (multiple ground-glass opacity-dominant nodules, consolidation/tumor ratio ≤0...
October 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29089687/follow-up-chest-radiographic-findings-in-patients-with-mers-cov-after-recovery
#16
Karuna M Das, Edward Y Lee, Rajvir Singh, Mushira A Enani, Khalid Al Dossari, Klaus Van Gorkom, Sven G Larsson, Ruth D Langer
PURPOSE: To evaluate the follow-up chest radiographic findings in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) who were discharged from the hospital following improved clinical symptoms. MATERIALS AND METHODS: Thirty-six consecutive patients (9 men, 27 women; age range 21-73 years, mean ± SD 42.5 ± 14.5 years) with confirmed MERS-CoV underwent follow-up chest radiographs after recovery from MERS-CoV. The 36 chest radiographs were obtained at 32 to 230 days with a median follow-up of 43 days...
July 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29078629/thoracoscopic-wedge-resection-and-segmentectomy-for-small-sized-pulmonary-nodules
#17
Hirohisa Kato, Hiroyuki Oizumi, Jun Suzuki, Akira Hamada, Hikaru Watarai, Kenta Nakahashi, Mitsuaki Sadahiro
With the recent increase in the detection of small-sized lung nodules because of the widespread use of computed tomography (CT), limited resection and minimally invasive surgery are preferred by patients with these lesions. In particular, the detection of nodules that show ground-glass opacity during high-resolution CT has increased. Although lobectomy and lymph node dissection were the standard procedures used for treating lung cancer, limited wedge resection and segmentectomy have become acceptable for treating small-sized lung cancers with nodules showing ground-glass opacity...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078627/anatomic-bisegmentectomy-for-synchronous-lung-adenocarcinoma
#18
Arthur Vieira, Paula Ugalde Figueroa
Modern thoracic surgery requires the ability to manage patients with ground glass opacities (GGO). However, due to the lack of a standardize approach in our institution these cases are discussed in the tumor board. We here present our therapeutic rationale in a case of a patient with multiple GGOs, who underwent an en-bloc anatomic bisegmentectomy as surgical treatment for a synchronous lung adenocarcinoma.
2017: J Vis Surg
https://www.readbyqxmd.com/read/29063257/detection-of-lung-carcinoma-with-predominant-ground-glass-opacity-on-ct-using-temporal-subtraction-method
#19
Takashi Terasawa, Takatoshi Aoki, Seiichi Murakami, Hyoungseop Kim, Masami Fujii, Michiko Kobayashi, Chihiro Chihara, Yoshiko Hayashida, Yukunori Korogi
PURPOSE: To evaluate the usefulness of the CT temporal subtraction (TS) method for the detection of the lung cancer with predominant ground-glass opacity (LC-pGGO). MATERIALS AND METHODS: Twenty-five pairs of CT and their TS images in patients with LC-pGGO (31 lesions) and 25 pairs of those in patients without nodules were used for an observer performance study. Eight radiologists participated and the statistical significance of differences with and without the CT-TS was assessed by JAFROC analysis...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29058073/the-rare-complication-and-diagnostic-challenges-of-pulmonary-eosinophilia-in-graft-versus-host-disease-patients-after-hematopoietic-stem-cell-transplantation
#20
Pierre Tawfik, Patrick Arndt
PURPOSE: Chronic graft versus host disease (cGvHD) is a common complication of hematopoietic stem cell transplantation (HSCT). Eosinophilic lung disease is a rare poorly understood complication in HSCT patients with cGvHD. These patients present similarly to those with Acute Eosinophilic Pneumonia (AEP). The purpose of this study is to better elucidate the presentation and potential treatment of this phenomenon. METHODS: We reviewed over 170 bronchoscopies in post-HSCT patients with respiratory symptoms...
December 2017: Lung
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