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https://www.readbyqxmd.com/read/29770737/diagnostic-accuracy-and-complications-of-ct-guided-core-needle-lung-biopsy-of-solid-and-part-solid-lesions
#1
Sam Yun, Hee Kang, Young Gyoung Shin, Beom Su Kim, Jun Gu Park, Min Jung Jung
OBJECTIVES: To evaluate whether diagnostic accuracy and complications of computed tomography (CT)-guided core needle biopsy(CNB) differ for solid and part-solid lung lesions. METHODS: This retrospective study included 354 consecutive patients from April 2012 to July 2016 who underwent CT-guided CNB of lung lesions by a radiologist. Patient demographics, lung lesions' characteristics; solid or part-solid, underlying pulmonary disease, distance of path, procedure time, complications (hemorrhage or pneumothorax), histopathological results of biopsy specimens and final diagnosis were reviewed...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29753514/ground-glass-opacities-imaging-pathology-and-gene-mutations
#2
Fenghao Sun, Junjie Xi, Cheng Zhan, Xiaodong Yang, Lin Wang, Yu Shi, Wei Jiang, Qun Wang
BACKGROUND: Lung cancer can be detected in its early stages with computed tomography (CT). Early lung adenocarcinoma often is displayed as ground glass opacity (GGO), an entity that has been well studied over the past decade. However, few studies have focused on the correlation between CT characteristics and pathologic subtype of GGO. We aimed to explore the correlation between CT characteristics, pathologic subtype, and gene mutation associated with GGO in an effort to aid in the treatment of lung adenocarcinoma...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29750110/non-specific-interstitial-pneumonia-associated-with-clinically-amyopathic-dermatomyositis-showing-crazy-paving-appearance-on-thin-section-lung-ct
#3
Yuya Aono, Tatsuru Eifuku, Tomohiro Uto, Jun Sato, Shiro Imokawa, Takafumi Suda
The "crazy paving" appearance consists of ground-glass opacity superimposed on a network of linear opacities on thin-section computed tomography (CT) images of the lung. This finding has been described in a variety of diseases but is extremely rare in patients with non-specific interstitial pneumonia (NSIP). We describe a 45-year-old woman with biopsy-proven NSIP associated with clinically amyopathic dermatomyositis that showed a "crazy paving" appearance on thin-section CT of the lung. Clinicians should include NSIP in the differential diagnosis in patients presenting with "crazy paving" appearance on thin-section chest CT...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29740120/the-clinical-characteristics-and-outcomes-of-follicular-bronchiolitis-in-chinese-adult-patients
#4
Ju Lu, Miao Ma, Qi Zhao, Fanqing Meng, Dongmei Wang, Hourong Cai, Mengshu Cao
Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31-55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737058/-risk-factors-of-respiratory-failure-in-the-dermatomyositis-patients-with-interstitial-lung-disease
#5
Su-Han Zhang, Yun Peng, Qi-Bing Xie, Geng Yin, Bing Yan
OBJECTIVE: To reveal the clinical features of respiratory failure (RF) in dermatomyositis (DM) patients with interstitial lung disease (ILD),and to explore risk factors of RF in these patients. METHODS: The medical data of 122 DM patients with ILD were retrospectively reviewed: 40 developed RF (RF group),82 did not develope RF (Non RF group). Clinical,laboratory and radiological variables were compared between RF patients and Non RF patients. Multivariate Logistic regression was used to analyze risk factors of RF...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29736852/thoracic-involvement-in-erdheim-chester-disease-computed-tomography-imaging-findings-and-their-association-with-the-braf-v600e-mutation
#6
S Mojdeh Mirmomen, Arlene Sirajuddin, Moozhan Nikpanah, Rolf Symons, Anna K Paschall, Ioannis Papageorgiou, William A Gahl, Kevin O'Brien, Juvianee I Estrada-Veras, Ashkan A Malayeri
OBJECTIVES: To investigate the computed tomography (CT) thoracic findings in Erdheim-Chester disease (ECD) and evaluate the association of these findings with the BRAFV600E mutation. METHODS: This was a prospective study of patients with ECD (n=61, men=46) who underwent thoracic CT imaging. CT examinations were independently interpreted by two experienced radiologists. Association of imaging findings with BRAFV600E was achieved via the Chi-square or Fisher's exact test and odds ratios (OR) with 95% confidence intervals (CI), as appropriate...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29735504/pneumonitis-a-serious-adverse-effect-of-pd-l1-inhibitors-including-pembrolizumab
#7
Frances Rickard, Catherine Hyams, Andrew T Low
A 70-year-old man presented with breathlessness, cough and fever while receiving pembrolizumab for melanoma. A CT pulmonary angiogram demonstrated small bilateral upper lobe segmental pulmonary emboli with patchy ground-glass opacities and basal perilobular consolidation, in keeping with organising pneumonia. He was treated for community-acquired pneumonia and pulmonary emboli but rapidly deteriorated, with increasing hypoxia and dyspnoea. He was admitted to the intensive care unit for support with continuous positive airway pressure and high flow nasal oxygen...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29735492/asthmatic-adult-with-marked-blood-eosinophilia-is-it-truly-asthma
#8
Shera Tan, Angela Takano, Aloysius Ho, Keng Leong Tan
A middle-aged woman presented with symptoms suggestive of allergic asthma but with markedly elevated peripheral eosinophilia. She did not respond to inhaled corticosteroids, thereby prompting further investigations. Chest radiograph was normal. CT of the chest revealed bi-apical ground glass opacities. Bronchoalveolar lavage revealed predominantly eosinophilic yield. Autoimmune screen was negative. Bone marrow biopsy showed a normocellular marrow with increased eosinophils. A diagnosis of chronic eosinophilic pneumonia (CEP) was made after exclusion of other causes of eosinophilia...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29732009/non-invasive-tumor-genotyping-using-radiogenomic-biomarkers-a-systematic-review-and-oncology-wide-pathway-analysis
#9
REVIEW
Robin W Jansen, Paul van Amstel, Roland M Martens, Irsan E Kooi, Pieter Wesseling, Adrianus J de Langen, Catharina W Menke-Van der Houven van Oordt, Bernard H E Jansen, Annette C Moll, Josephine C Dorsman, Jonas A Castelijns, Pim de Graaf, Marcus C de Jong
With targeted treatments playing an increasing role in oncology, the need arises for fast non-invasive genotyping in clinical practice. Radiogenomics is a rapidly evolving field of research aimed at identifying imaging biomarkers useful for non-invasive genotyping. Radiogenomic genotyping has the advantage that it can capture tumor heterogeneity, can be performed repeatedly for treatment monitoring, and can be performed in malignancies for which biopsy is not available. In this systematic review of 187 included articles, we compiled a database of radiogenomic associations and unraveled networks of imaging groups and gene pathways oncology-wide...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29728140/solid-component-proportion-is-an-important-predictor-of-tumor-invasiveness-in-clinical-stage-t-1-n-0-m-0-ct-1-n-0-m-0-lung-adenocarcinoma
#10
Meng Li, Ning Wu, Li Zhang, Wei Sun, Ying Liu, Lv Lv, Jiansong Ren, Dongmei Lin
BACKGROUND: Preoperative tumor invasiveness in clinical stage T1 N0 M0 lung adenocarcinoma is critical for optimal surgical procedure. The aim of the present study was to evaluate the relationship between the ground-glass opacity component (GGOc) / solid component (Sc) proportion measured using three-dimensional (3D) computer-quantified computer tomography (CT) number analysis to explore radiographic features for invasiveness prediction in cT1 N0 M0 lung adenocarcinomas. METHODS: A total of 375 surgically resected cT1 N0 M0 lung adenocarcinoma patients were included...
May 4, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29719801/an-unusual-presentation-of-a-case-of-human-psittacosis
#11
Yannick Vande Weygaerde, Charlot Versteele, Elke Thijs, Anton De Spiegeleer, Jerina Boelens, Daisy Vanrompay, Eva Van Braeckel, Karim Vermaelen
Background: Chlamydia psittaci is a gram-negative, obligate intracellular organism. Birds are the main reservoir, but also non-avian domestic animals and humans can be infected. In humans it mostly causes respiratory infections due to occupational exposure with varying severity. Sensitive and specific diagnostic tests are needed to define psittacosis in humans as these tests also allow rapid tracing of the animal source. However, diagnosis in humans is often based on time-consuming culture techniques and antibody detection assays as in many countries, the existing molecular diagnostic tests for psittacosis are not reimbursed by the public health insurance...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29719437/a-new-predictive-scoring-system-based-on-clinical-data-and-computed-tomography-features-for-diagnosing-egfr-mutated-lung-adenocarcinoma
#12
Y Cao, H Xu
Background: We aimed to develop a new EGFR mutation-predictive scoring system to use in screening for EGFR -mutated lung adenocarcinomas (lacs). Methods: The study enrolled 279 patients with lac, including 121 patients with EGFR wild-type tumours and 158 with EGFR -mutated tumours. The Student t-test, chi-square test, or Fisher exact test was applied to discriminate clinical and computed tomography (ct) features between the two groups. Using a principal component analysis (pca) model, we derived predictive coefficients for the presence of EGFR mutation in lac...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29716649/preexisting-radiological-interstitial-lung-abnormalities-are-a-risk-factor-for-severe-radiation-pneumonitis-in-patients-with-small-cell-lung-cancer-after-thoracic-radiation-therapy
#13
Fangjuan Li, Ziyang Zhou, Ailu Wu, Yong Cai, Hongyu Wu, Ming Chen, Shixiong Liang
BACKGROUND: Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT). The present study aimed to evaluate the incidence and predictors of RP after TRT in patients with small-cell lung cancer (SCLC) with or without preexisting radiological ILAs. METHODS: A total of 95 consecutive patients with SCLC between January 2015 and December 2015, who were treated with thoracic intensity-modulated radiation therapy at Shanghai Pulmonary Hospital,Tongji University School of Medicine, were analyzed...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29708176/multifocal-ground-glass-opacities-multifocal-origin-versus-intrapulmonary-metastasis
#14
EDITORIAL
Choon-Taek Lee
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707338/virtual-assisted-lung-mapping-val-map-shortened-surgical-time-of-wedge-resection
#15
Taiji Kuwata, Shuichi Shinohara, Hiroki Matsumiya, Masaru Takenaka, Soichi Oka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Fumihiro Tanaka
Background: The detection of extremely small lung tumors has increased with the development of computed tomography. Resection of such tumors by thoracoscopy is often hindered due to the unclear location of the tumor. Various methods of preoperative determination of such lesions have been attempted, but without marked success. Here we used virtual-assisted lung mapping (VAL-MAP) to perform surgical resection of small lung lesions. Methods: We selected patients with pulmonary tumors that we anticipated to be difficult to identify during thoracoscopy and/or decide the resection line for sub-lobar lung resection...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29697078/high-resolution-computerized-tomography-changes-in-diffuse-parenchymal-lung-disease-from-chronic-hypersensitivity-pneumonitis-related-to-bird-antigen
#16
Parthasarathi Bhattacharyya, Sanjukta Dasgupta, Mintu Paul, Dipanjan Saha, Sayoni Sengupta, Pinak Pani Bhattacharyya
Background: Chronic hypersensitivity pneumonitis (HP) is the most common cause of diffuse parenchymal lung disease (DPLD) in India. There is no data regarding the avian antigen exposure-associated DPLD from the country. Methods: Chronic HP from exposure to avian antigen was diagnosed when the high resolution computerized tomography (HRCT) showed features for HP and was supported by the history of exposure to pigeons, the presence of precipitin antibodies (IgG) to avian antigen in high titre with negative rheumatoid factor, antinuclear antibody, and no clinical clue for a collagen vascular disease...
May 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29696225/logis-localization-of-ground-glass-opacity-and-pulmonary-lesions-for-minimal-surgery-registry-design-and-rationale
#17
Chul Hwan Park, Dong Jin Im, Sang Min Lee, Ji Won Lee, Sung Ho Hwang, Semin Chong, Min Jae Cha, Kye Ho Lee, Woocheol Kwon, Hwan Seok Yong, Jae Wook Lee, Gong Yong Jin, Sang Hyun Paik, Kyunghwa Han, Jin Hur
Background and purpose: An optimal pulmonary localization technique for video-assisted thoracic surgery (VATS) of small lung nodules has not yet been established. The LOcalization of Ground-glass-opacity and pulmonary lesions for mInimal Surgery (LOGIS) registry aims to establish a multicenter database and investigate the usefulness and safety of localization techniques for small pulmonary lesions in individuals undergoing VATS. Methods/Design: The LOGIS registry is a large-scale, multicenter cohort study, aiming to enroll 825 patients at 10 institutions...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29687227/high-resolution-ct-findings-of-pulmonary-interstitial-glycogenosis
#18
Jason P Weinman, Christina J White, Deborah R Liptzin, Robin R Deterding, Csaba Galambos, Lorna P Browne
BACKGROUND: Pulmonary interstitial glycogenosis is a form of childhood interstitial lung disease characterized by the histological finding of abundant glycogen-laden mesenchymal cells within the pulmonary interstitium. Patients present in the neonatal period with disproportionate respiratory distress. Often, pulmonary interstitial glycogenosis is accompanied by alveolar simplification complicating recognition and diagnosis. Despite the recognition of pulmonary interstitial glycogenosis as a distinct entity, only a few case reports describing imaging findings are found in the literature, with no published systematic review available...
April 23, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29666992/preoperative-localisation-of-pulmonary-ground-glass-opacity-using-medical-adhesive-before-thoracoscopic-resection
#19
Ren-Li Cen, Fei Cui, Qi Wan, Ling Chen, Xiao-Yan Huang, Jia-Xuan Zhou, Shu-Ben Li, Qing-Si Zeng, Jian-Xing He
OBJECTIVES: To evaluate the safety and efficiency of computed tomography (CT)-guided medical adhesive, α-cyanoacrylate, for preoperative localisation of pulmonary ground-glass opacity (GGO) used for guiding the video-assisted thoracoscopic surgical (VATS) excision METHODS: The procedure was performed on 188 consecutive patients with solitary GGO (pure GGO = 90 cases; mixed GGO = 98 cases) prior to the thoracoscopic procedure. The complications and efficacy of this method were analysed...
April 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29666813/ground-glass-opacities-management-in-the-lung-cancer-screening-era
#20
REVIEW
Marcello Migliore, Mariaconcetta Fornito, Manuela Palazzolo, Alessandra Criscione, Mariapia Gangemi, Francesco Borrata, Paolo Vigneri, Marco Nardini, Joel Dunning
Pulmonary ground glass opacity (GGO) is becoming an important clinical dilemma in oncology as its diagnosis in clinical practice is increasing due to the introduction of low dose computed tomography (CT) scan and screening. The incidence of cancer in GGO has been reported as high as 63%. The purpose of this manuscript is to review best available evidence papers on management of GGO in lung cancer to address the following questions: (I) how to correlate CT findings with malignancy; (II) when and who operate? (III) how to perform intraoperative detection of intrapulmonary GGO? (IV) wedge, segmentectomy or lobectomy? Taking a cue from a clinical scenario, a review on PubMed was conducted...
March 2018: Annals of Translational Medicine
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