keyword
MENU ▼
Read by QxMD icon Read
search

Alcohol and nicotine

keyword
https://www.readbyqxmd.com/read/28922393/a-set-of-nutrient-limitations-trigger-yeast-cell-death-in-a-nitrogen-dependent-manner-during-wine-alcoholic-fermentation
#1
Camille Duc, Martine Pradal, Isabelle Sanchez, Jessica Noble, Catherine Tesnière, Bruno Blondin
Yeast cell death can occur during wine alcoholic fermentation. It is generally considered to result from ethanol stress that impacts membrane integrity. This cell death mainly occurs when grape musts processing reduces lipid availability, resulting in weaker membrane resistance to ethanol. However the mechanisms underlying cell death in these conditions remain unclear. We examined cell death occurrence considering yeast cells ability to elicit an appropriate response to a given nutrient limitation and thus survive starvation...
2017: PloS One
https://www.readbyqxmd.com/read/28919445/cognitive-effects-of-labeled-addictolytic-medications
#2
REVIEW
Camille Noélie Pujol, Cecilia Paasche, Vincent Laprevote, Benoit Trojak, Pierre Vidailhet, Elisabeth Bacon, Laurence Lalanne
INTRODUCTION: Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. Many pharmacotherapies have been developed over the last 50years to target addictive disorders. While the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. However, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28918668/current-status-and-future-prospects-for-the-development-of-substance-abuse-vaccines
#3
Thomas R Kosten, Daryl Shorter, David Heekin
Substance use disorders (SUD) are a significant threat to both individual and public health. To date, SUD pharmacotherapy has focused primarily on agonist medications (i.e., nicotine replacement therapy for tobacco use disorder; methadone and buprenorphine for opioid use disorder), antagonist medications (i.e., naltrexone for opioid use disorder), and aversive therapy (i.e., disulfiram for alcohol use disorder). Pharmacotherapeutic approaches utilizing an immunological framework for medication development represent an important focus of study for treatment of these illnesses...
September 18, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28901722/%C3%AE-6-subunit-containing-nicotinic-receptors-mediate-low-dose-ethanol-effects-on-ventral-tegmental-area-neurons-and-ethanol-reward
#4
Scott C Steffensen, Samuel I Shin, Ashley C Nelson, Stephanie S Pistorius, Stephanie B Williams, Taylor J Woodward, Hyun Jung Park, Lindsey Friend, Ming Gao, Fenfei Gao, Devin H Taylor, M Foster Olive, Jeffrey G Edwards, Sterling N Sudweeks, Lori M Buhlman, J Michael McIntosh, Jie Wu
Dopamine (DA) neuron excitability is regulated by inhibitory GABAergic synaptic transmission and modulated by nicotinic acetylcholine receptors (nAChRs). The aim of this study was to evaluate the role of α6 subunit-containing nAChRs (α6*-nAChRs) in acute ethanol effects on ventral tegmental area (VTA) GABA and DA neurons. α6*-nAChRs were visualized on GABA terminals on VTA GABA neurons, and α6*-nAChR transcripts were expressed in most DA neurons, but only a minority of VTA GABA neurons from GAD67 GFP mice...
September 13, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28892072/neuregulin-signaling-pathway-in-smoking-behavior
#5
R Gupta, B Qaiser, L He, T S Hiekkalinna, A B Zheutlin, S Therman, M Ollikainen, S Ripatti, M Perola, V Salomaa, L Milani, T D Cannon, P A F Madden, T Korhonen, J Kaprio, A Loukola
Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, a neurodevelopmental disorder with high comorbidity to smoking. Using a Finnish twin family sample, we have previously detected association between nicotine dependence and ERBB4 (a neuregulin receptor), and linkage for smoking initiation at the ERBB4 locus on 2q33. Further, Neuregulin3 has recently been shown to associate with nicotine withdrawal in a behavioral mouse model...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28876167/sexual-orientation-based-discrimination-excessive-alcohol-use-and-substance-use-disorders-among-sexual-minority-adults
#6
Megan E Slater, Dionne Godette, Boji Huang, W June Ruan, Bradley T Kerridge
PURPOSE: The purpose of this study was to examine relationships between sexual orientation-based discrimination and excessive alcohol use and substance use disorders and to identify how these relationships differ by sexual identity, sex, race, Hispanic origin, and education among sexual minorities. METHODS: We used logistic regression to analyze associations between discrimination and substance use measures among 1351 gay/lesbian, bisexual, or unsure adults from a nationally representative survey...
September 6, 2017: LGBT Health
https://www.readbyqxmd.com/read/28867415/gender-differences-in-mental-and-physical-health-conditions-in-u-s-veterans-results-from-the-national-health-and-resilience-in-veterans-study
#7
Hannah Ziobrowski, Carolyn E Sartor, Jack Tsai, Robert H Pietrzak
OBJECTIVES: To characterize gender differences in the prevalence of mental and physical health conditions and evaluate the moderating effect of assaultive trauma on risk for these conditions in a nationally representative sample of male and female U.S. veterans. METHODS: Cross-sectional data were analyzed from 3157 U.S. veterans from the National Health and Resilience in Veterans Study. Multivariable logistic regression analyses assessed gender differences in health outcomes and evaluated physical and sexual trauma as possible moderators of these outcomes...
October 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28860980/chronic-nicotine-exposure-initiated-in-adolescence-and-unpaired-to-behavioral-context-fails-to-enhance-sweetened-ethanol-seeking
#8
Aric C Madayag, Kyle S Czarnecki, Lynde M Wangler, Donita L Robinson
Nicotine use in adolescence is pervasive in the United States and, according to the Gateway Hypothesis, may lead to progression towards other addictive substances. Given the prevalence of nicotine and ethanol comorbidity, it is difficult to ascertain if nicotine is a gateway drug for ethanol. Our study investigated the relationship between adolescent exposure to nicotine and whether this exposure alters subsequent alcohol seeking behavior. We hypothesized that rats exposed to nicotine beginning in adolescence would exhibit greater alcohol seeking behavior than non-exposed siblings...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28858694/recent-cannabis-use-among-veterans-in-the-united-states-results-from-a-national-sample
#9
Alan K Davis, Lewei A Lin, Mark A Ilgen, Kipling M Bohnert
BACKGROUND: Compared to civilians, little is known about cannabis use among Veterans in the general United States (US) population. This study aimed to examine the prevalence and correlates of recent medical and non-medical cannabis use among this important US sub-population. METHOD: Data came from the 2014 National Survey on Drug Use and Health. Bivariate and multivariable analyses were conducted that were weighted to account for the complex survey design. RESULTS: Approximately 9% of Veterans in the US reported past year cannabis use...
August 18, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28858691/pharmacological-challenge-studies-with-acute-psychosocial-stress
#10
REVIEW
Kathryne Van Hedger, Anya K Bershad, Harriet de Wit
Chronic stress is known to affect many psychiatric disorders, and studies of responses to acute stress may reveal processes that ultimately lead to maladaptive responses to chronic stress. Many studies have used simulated public speaking tasks to induce stress in the laboratory and, of interest to this review, the tasks have been used to assess the effects of both therapeutic and nonmedical drugs on stress reactivity. Here we review 38 studies that examined effects of single doses of drugs on subjective, cardiovascular and hormonal responses to an acute social stressor in healthy volunteers...
August 22, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28846958/substance-use-disorders-and-self-and-other-directed-violence-among-adults-results-from-the-national-survey-on-drug-use-and-health
#11
Thomas C Harford, Hsiao-Ye Yi, Chiung M Chen, Bridget F Grant
BACKGROUND: Previous studies have identified a violence typology of self- and other-directed violence. This study examines the extent to which substance use disorders (SUDs) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), independent of serious psychological distress, major depressive episodes, assault arrest, and criminal justice involvement, are associated with these violence categories. METHOD: Data were obtained from the National Survey on Drug Use and Health (NSDUH) pooled across survey years 2008-2015, with a combined sample of 314,881 adult respondents...
August 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28833225/the-glycine-receptor-a-functionally-important-primary-brain-target-of-ethanol
#12
Bo Söderpalm, Helga HöifödtLidö, Mia Ericson
Identification of ethanol's primary molecular brain targets and determination of their functional importance is an ongoing, important quest. Pentameric ligand-gated ion-channels (pLGIC), i.e. the nicotinic acetylcholine receptor, the γ-aminobutyric acid type A receptor, the 5-hydroxytryptamine3 and the glycine receptor (GlyR) are such targets. Here, aspects of the structure and function of these receptors and ethanol's interaction with them are briefly reviewed, with special emphasis on the GlyR and the importance of this receptor and its ligands for ethanol pharmacology...
August 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28833206/sonographic-differentiation-between-lymphatic-and-metastatic-diseases-in-cervical-lymphadenopathy
#13
Ulrich Strassen, Christina Geisweid, Benedikt Hofauer, Andreas Knopf
OBJECTIVES/HYPOTHESIS: The spectrum of differential diagnosis in cervical lymphadenopathy is extremely broad. In lymphoma and inflammatory diseases, surgical approaches are restricted to diagnostic lymph extirpation, whereas metastatic outgrowth into regional lymph nodes usually requires neck dissection. Lymph node surgery has to manage the balancing act between sufficient radicality and preservation of functional structures. The current study, therefore, aimed to identify parameters to differentiate between lymph nodes of lymphatic and metastatic origin...
August 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28827839/lean-diabetes-in-middle-aged-adults-a-joint-analysis-of-the-german-dive-and-dpv-registries
#14
Bettina Hartmann, Stefanie Lanzinger, Peter Bramlage, Felix Groß, Thomas Danne, Siegfried Wagner, Dietmar Krakow, Artur Zimmermann, Christian Malcharzik, Reinhard W Holl
AIMS: To assess differences in demographics, treatment and outcome of lean (LD) compared to overweight and obese people with diabetes clinically classified as type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We combined data from the German DIVE (Diabetes Versorgungs-Evaluation) and DPV (Diabetes-Patienten-Verlaufsdokumentation) databases to produce a large cohort of people with T2DM. The characteristics of people with Body Mass Index (BMI) <25 kg/m2, ≥25-30 kg/m2 and ≥30 kg/m2 aged 30 to 50 years were compared, including demographics, cardiovascular (CV) risk factors, comorbidities and outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28818082/comparing-chronic-condition-rates-using-icd-9-and-icd-10-in-va-patients-fy2014-2016
#15
Jean Yoon, Adam Chow
BACKGROUND: Management of patients with chronic conditions relies on accurate measurement. It is unknown how transition to the ICD-10 coding system affected reporting of chronic condition rates over time. We measured chronic condition rates 2 years before and 1 year after the transition to ICD-10 to examine changes in prevalence rates and potential measurement issues in the Veterans Affairs (VA) health care system. METHODS: We developed definitions for 34 chronic conditions using ICD-9 and ICD-10 codes and compared the prevalence rates of these conditions from FY2014 to 2016 in a 20% random sample (1...
August 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28816928/psychotic-symptoms-associated-with-varenicline-in-a-patient-with-alcohol-and-nicotine-dependence-a-case-report
#16
Fumihiko Ueno, Hiroyuki Uchida, Takefumi Suzuki, Akira Yokoyama, Sachio Matsushita, Masaru Mimura, Susumu Higuchi
No abstract text is available yet for this article.
August 14, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28813208/substance-use-and-dependence-among-current-reserve-and-former-military-members-cross-sectional-findings-from-the-national-survey-on-drug-use-and-health-2010-2014
#17
Rachel A Hoopsick, Jennifer Fillo, Bonnie M Vest, D Lynn Homish, Gregory G Homish
Maladjustment after leaving the military may contribute to poor health outcomes, including increased risk for substance use and dependence. The authors examined differences in substance use and dependence on the basis of military involvement in a large nationally representative sample. Data are from a subset of the 2010-2014 waves of the National Survey on Drug Use and Health (n = 5,608). The sample included men (81.9%) and women (18.1%) aged 20-49 years who had either separated/retired from the military (n = 4,862) or were a current reserve service member (n = 746)...
August 16, 2017: Journal of Addictive Diseases
https://www.readbyqxmd.com/read/28804788/pro-dopamine-regulator-kb220-to-balance-brain-reward-circuitry-in-reward-deficiency-syndrome-rds
#18
Kenneth Blum, Marcelo Febo, Lyle Fried, David Baron, Eric R Braverman, Kristina Dushaj, Mona Li, Zsolt Demetrovics, Rajendra D Badgaiyan
We are faced with a worldwide opiate/opioid epidemic that is devastating. According to the Centers for Disease Control and Prevention (CDC), at least 127 people, young and old, are dying every day in America due to narcotic overdose. The Food and Drug Administration (FDA) has approved Medication-Assisted Treatments (MATs) for opiate/opioids as well as alcohol and nicotine. The mechanism of action of most MATS favors either blocking of dopaminergic function or a form of Opiate Substitution Therapy (OST). These treatment options are adequate for short-term treatment of the symptoms of addiction and harm reduction but fail long-term to deal with the cause or lead to recovery...
2017: Journal of Reward Deficiency Syndrome and Addiction Science
https://www.readbyqxmd.com/read/28792283/reasons-for-marijuana-and-tobacco-co-use-among-young-adults-a-mixed-methods-scale-development-study
#19
Carla J Berg, Jackelyn Payne, Lisa Henriksen, Patricia Cavazos-Rehg, Betelihem Getachew, Gillian L Schauer, Regine Haardörfer
BACKGROUND: Marijuana-tobacco co-use has increased recently, particularly in young adults. OBJECTIVES: We conducted a mixed-methods study to: (1) examine reasons for co-use; and (2) develop a scale assessing reasons for co-use among participants in a longitudinal cohort study of 3,418 students aged 18-25 from 7 Georgia colleges and universities. METHODS: Phone-based semi-structured interviews were conducted in Summer 2015 among 46 current (past 30-day, n = 26) or lifetime (n = 20) marijuana users...
August 9, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28777675/electronic-nicotine-delivery-systems-e-cigarette-vape-use-and-co-occurring-health-risk-behaviors-among-an-ethnically-diverse-sample-of-young-adults
#20
H Isabella Lanza, Heather Teeter
BACKGROUND: Prevalence rates of electronic nicotine delivery systems (ENDS; i.e., e-cigarette/vape) use has grown exponentially in the past few years. College students present a particularly vulnerable group for ENDS use. The current study sought to expand the literature by examining the context in which college students use ENDS, co-occurring health risks beyond traditional tobacco use, and the role of ethnicity in ENDS use. METHODS: Health-risk behavior survey data was collected from 452 undergraduates attending a large, public urban university during the 2015-2016 academic year...
August 4, 2017: Substance Use & Misuse
keyword
keyword
32204
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"