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https://www.readbyqxmd.com/read/28736408/a-culture-of-understanding-reflections-and-suggestions-from-a-genomics-research-community-board
#1
Benjamin Kaplan, Carolyn Caddle-Steele, Gregory Chisholm, Warria A Esmond, Kadija Ferryman, Melvin Gertner, Crispin Goytia, Diane Hauser, Lynne D Richardson, Mimsie Robinson, Carol R Horowitz
There has been limited community engagement in the burgeoning field of genomics research. In the wake of a new discovery of genetic variants that increase the risk of kidney failure and are almost unique to people of African ancestry, community and clinical leaders in Harlem, New York, formed a community board to inform the direction of related research. The board advised all aspects of a study to assess the impact of testing for these genetic variants at primary care sites that serve diverse populations, including explaining genetic risk to participants...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/28735291/subclinical-atherosclerosis-cardiac-and-kidney-function-heart-failure-and-dementia-in-the-very-elderly
#2
Lewis H Kuller, Oscar L Lopez, John S Gottdiener, Dalane W Kitzman, James T Becker, Yuefang Chang, Anne B Newman
BACKGROUND: Heart failure (HF) and dementia are major causes of disability and death among older individuals. Risk factors and biomarkers of HF may be determinants of dementia in the elderly. We evaluated the relationship between biomarkers of cardiovascular disease and HF and risk of dementia and death. Three hypotheses were tested: (1) higher levels of high-sensitivity cardiac troponin T, N-terminal of prohormone brain natriuretic peptide, and cystatin C predict risk of death, cardiovascular disease, HF, and dementia; (2) higher levels of cardiovascular disease biomarkers are associated with increased risk of HF and then secondary increased risk of dementia; and (3) risk of dementia is lower among participants with a combination of lower coronary artery calcium, atherosclerosis, and lower high-sensitivity cardiac troponin T (myocardial injury)...
July 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28729967/tesevatinib-ameliorates-progression-of-polycystic-kidney-disease-in-rodent-models-of-autosomal-recessive-polycystic-kidney-disease
#3
William E Sweeney, Philip Frost, Ellis D Avner
AIM: To investigate the therapeutic potential of tesevatinib (TSV), a unique multi-kinase inhibitor currently in Phase II clinical trials for autosomal dominant polycystic kidney disease (ADPKD), in well-defined rodent models of autosomal recessive polycystic kidney disease (ARPKD). METHODS: We administered TSV in daily doses of 7.5 and 15 mg/kg per day by I.P. to the well characterized bpk model of polycystic kidney disease starting at postnatal day (PN) 4 through PN21 to assess efficacy and toxicity in neonatal mice during postnatal development and still undergoing renal maturation...
July 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28729383/definitions-and-end-points-for-interventional-studies-for-arteriovenous-dialysis-access
#4
Gerald A Beathard, Charmaine E Lok, Marc H Glickman, Ahmed A Al-Jaishi, Donna Bednarski, David L Cull, Jeffery H Lawson, Timmy C Lee, Vandana D Niyyar, Donna Syracuse, Scott O Trerotola, Prabir Roy-Chaudhury, Surendra Shenoy, Margo Underwood, Haimanot Wasse, Karen Woo, Theodore H Yuo, Thomas S Huber
This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points which would be best suited to inform decisions in those situations in which supportive clinical data are required. The focus of a portion of the project is directed toward arteriovenous access. There is a potential for interventional studies to be directed toward any of the events that may be associated with an arteriovenous access' evolution throughout its life cycle, which has been divided into five distinct phases...
July 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28727072/the-equine-glucose-dependent-insulinotropic-polypeptide-receptor-a-potential-therapeutic-target-for-insulin-dysregulation
#5
M H Kheder, M N Sillence, L M Bryant, M A de Laat
Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent insulinotropic polypeptide (GIP) biology has led to the suggestion that inhibiting its action may attenuate obesity in several species. In horses, antagonism of GIP may also reduce hyperinsulinemia, which leads to insulin-associated laminitis, a painful comorbidity unique to this species. However, little is known about GIP in horses. The aims of this study were to examine the tissue distribution of equine GIP receptors (eGIPR), to determine whether eGIPR can be blocked using a GIP antagonist not tested previously in horses, and to establish whether there is any association between GIP concentrations and body mass in this species...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28720662/proximal-tubule-apical-endocytosis-is-modulated-by-fluid-shear-stress-via-an-mtor-dependent-pathway
#6
Kimberly R Long, Katherine E Shipman, Youssef Rbaibi, Elizabeth V Menshikova, Vladimir B Ritov, Megan L Eshbach, Yu Jiang, Edwin K Jackson, Catherine J Baty, Ora A Weisz
Cells lining the proximal tubule (PT) have unique membrane specializations that are required to maintain the high capacity ion transport and endocytic functions of this nephron segment. PT cells in vivo acutely regulate ion transport in response to changes in glomerular filtration rate (GFR) to maintain glomerulotubular balance. PT cells in culture upregulate endocytic capacity in response to acute changes in fluid shear stress (FSS); however it is not known whether GFR modulates PT endocytosis to enable maximally efficient uptake of filtered proteins in vivo Here we show that cells cultured under continuous FSS develop an expanded apical endocytic pathway as well as increased endocytic capacity and lysosomal biogenesis...
July 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28719376/stability-of-spironolactone-oral-suspension-in-pcca-base-suspendit
#7
Richard Graves, Kelly V Phan, Levon A Bostanian, Tarun K Mandal, Yashoda V Pramar
Spironolactone (Aldactone) is a potassium-sparing diuretic used to treat hypertension and heart failure and may also be used to treat edema resulting from kidney disease, low potassium levels, or excess aldosterone. No commercial liquid dosage form of spironolactone exists. An extemporaneously compounded suspension from pure drug powder or commercial tablets would provide an alternative option to meet unique patient needs. The purpose of this study was to determine the physicochemical stability of spironolactone in the PCCA base SuspendIt...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28716974/heart-failure-in-patients-with-kidney-disease
#8
REVIEW
Courtney Tuegel, Nisha Bansal
Heart failure (HF) is a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD), and the population of CKD patients with concurrent HF continues to grow. The accurate diagnosis of HF is challenging in patients with CKD in part due to a lack of validated imaging and biomarkers specifically in this population. The pathophysiology between the heart and the kidneys is complex and bidirectional. Patients with CKD have greater prevalence of traditional HF risk factors as well as unique kidney-specific risk factors including malnutrition, acid-base alterations, uraemic toxins, bone mineral changes, anemia and myocardial stunning...
July 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28714420/evaluation-of-temporal-changes-in-urine-based-metabolomic-and-kidney-injury-markers-to-detect-compound-induced-acute-kidney-tubular-toxicity-in-beagle-dogs
#9
M P Wagoner, Y Yang, J E McDuffie, M Klapczynski, W Buck, L Cheatham, D Eisinger, F Sace, K M Lynch, M Sonee, J-Y Ma, Y Chen, K Marshall, M Damour, L Stephen, Y P Dragan, J Fikes, S Snook, L B Kinter
Urinary protein biomarkers and metabolomic markers have been leveraged to detect acute drug induced kidney injury (DIKI) in rats; however, the utility of these indicators to enable early detection of DIKI in canine models has not been well documented. Therefore, we evaluated temporal changes in biomarkers and metabolites in urine from male and female beagle dogs. Gentamicin-induced kidney lesions in male dogs were characterized by moderate to severe tubular epithelial cell degeneration/necrosis, epithelial cell regeneration and dilation; and a unique urine-based metabolomic fingerprint...
July 13, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28711081/illustrative-cases-of-kidney-disease-unique-to-women
#10
Iru Chen, Liz Lightsone, Michelle A Hladunewich, Belinda Jim
No abstract text is available yet for this article.
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28711070/female-adolescents-with-chronic-or-end-stage-kidney-disease-and-strategies-for-their-care
#11
Maria E Diaz-Gonzalez De Ferris, Ana Catalina Alvarez-Elías, Michael Ted Ferris, Mara Medeiros
The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to lower muscle mass. Females have higher nitric oxide activity, and estrogens may contribute to lower blood pressure. Females excrete less growth hormone during the prepubertal and pubertal years...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28704129/electromagnetic-information-transfer-through-aqueous-system
#12
Alberto Foletti, Mario Ledda, Maria Grazia Lolli, Settimio Grimaldi, Antonella Lisi
Several beneficial effects of the electromagnetic information transfer through aqueous system (EMITTAS) procedure have previously been reported in vitro. The clinical potential of this procedure has also started to be evaluated. Information flow in biological systems can be investigated through chemical and molecular approaches or by a biophysical approach focused on endogenous electrodynamic activities. Electromagnetic signals are endogenously generated at different levels of the biological organization and, likely, play an active role in synchronizing internal cell function or local/systemic adaptive response...
July 13, 2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/28701807/natriuretic-peptides-as-biomarkers-for-congestive-states-the-cardiorenal-divergence
#13
REVIEW
Abhilash Koratala, Amir Kazory
Congestion represents the primary reason for hospitalization of patients with heart failure and is associated with adverse outcomes. Fluid overload has been shown to be inadequately addressed in a significant subset of these patients in part due to lack of robust, reliable, and readily available biomarkers for objective assessment and monitoring of therapy. Natriuretic peptides have long been used in this setting, often in conjunction with other assessment tools such as imaging studies. Patients presenting with concomitant cardiac and renal dysfunction represent a unique population with regard to congestion in that the interactions between the heart and the kidney can affect the utility and performance of biomarkers of fluid overload...
2017: Disease Markers
https://www.readbyqxmd.com/read/28701313/dynamic-regulation-of-lysine-acetylation-the-balance-between-acetyltransferase-and-deacetylase-activities
#14
Kelly A Hyndman, Mark A Knepper
Reversible posttranslational modification (PTM) of proteins is a critically important process in physiological regulation in all tissues including the kidney. Lysine acetylation occurs in all organisms including prokaryotes, and is regulated by a balance between the lysine acetyltransferases (adding an acetyl group to the ε-amino group of a lysine) and deacetylases (removing it). The kidney is an organ rich with acetylated lysines which map to >2000 unique histone and non-histone proteins. However, the functional significance of these modifications remains to be discovered...
July 12, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28698815/glomangioma-of-the-kidney-a-rare-case-of-glomus-tumor-and-review-of-the-literature
#15
Ammar Almaghrabi, Nizar Almaghrabi, Haneen Al-Maghrabi
BACKGROUND: Glomus tumors are rare mesenchymal tumors originating from glomus bodies in the skin. Glomus tumors of the kidney are rare tumors and only a few cases have been reported in the medical literature. An extensive search revealed a very limited number of primary renal glomus tumors. Although most of these cases were benign in nature, including a case with uncertain diagnosis of malignant potential, two were malignant. CASE REPORT: We present a unique case of a 57-year-old male patient with an incidentally discovered 2 cm left renal mass...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28698303/evaluation-of-expression-and-glycosylation-status-of-ugt1a10-in-supersomes-and-intestinal-epithelial-cells-with-a-novel-specific-ugt1a10-monoclonal-antibody
#16
Shingo Oda, Yukiko Kato, Masahiko Hatakeyama, Atsushi Iwamura, Tatsuki Fukami, Toshiyuki Kume, Tsuyoshi Yokoi, Miki Nakajima
UDP-Glucuronosyltransferases (UGTs) are major phase II drug-metabolizing enzymes. Each member of the UGT family exhibits a unique but occasionally overlapping substrate specificity and tissue-specific expression pattern. Earlier studies have reported that human UGT1A10 is expressed in the gastrointestinal tract at the mRNA level, but the evaluation at the protein level, especially tissue or cellular localization, has lagged behind because of the lack of a specific antibody. In this study, we prepared a monoclonal antibody against UGT1A10 to elucidate the tissue/cellular distribution and interindividual variability of UGT1A10 protein expression...
July 11, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28695491/identification-and-characterization-of-the-chinese-giant-salamander-andrias-davidianus-mirnas-by-deep-sequencing-and-predication-of-their-targets
#17
Yong Huang, You Bing Yang, Xiao Chan Gao, Hong Tao Ren, Xi Hong Sun
MicroRNAs (miRNAs) are non-coding small RNA of approximately 22 nt in length. They are considered as key regulators for gene expression at the post-transcriptional level and play an important role in the regulation of many fundamental biological processes. Andrias davidianus, as one of the largest amphibian on earth, may represent the transitional type of animal from aquatic to terrestrial life, but so far, no miRNA has been identified in the species. In this study, Illumina deep sequencing was used for high-throughput analysis of miRNAs in a pooled small RNA library isolated from eight tissues sample of A...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28695430/birt-hogg-dub%C3%A3-syndrome-a-review-of-dermatological-manifestations-and-other-symptoms
#18
REVIEW
Yun Tong, Jeremy A Schneider, Alvin B Coda, Tissa R Hata, Philip R Cohen
Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant genodermatosis with malignant potential characterized by cutaneous and extracutaneous stigmata. Aberrations in the folliculin (FLCN) gene, which is located on chromosome 17, have been discovered in individuals with this condition. Over 150 unique mutations have been identified in BHD. The skin lesions associated with this condition include fibrofolliculomas, trichodiscomas, perifollicular fibromas, and acrochordons. Extracutaneous features of the syndrome typically include the lung (spontaneous pneumothorax and cysts) and the kidney (neoplasms)...
July 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28693440/serum-lactate-level-and-mortality-in-metformin-associated-lactic-acidosis-requiring-renal-replacement-therapy-a-systematic-review-of-case-reports-and-case-series
#19
Hung-Chieh Yeh, I-Wen Ting, Ching-Wei Tsai, Jenn-Yu Wu, Chin-Chi Kuo
BACKGROUND: The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown. To investigate whether serum lactate level and prescription pattern of RRT are associated with mortality in patients with MALA requiring RRT. METHODS: We searched PubMed/Medline and EMBASE from inception to Sep 2014 and applied predetermined exclusion criteria. Case-level data including case's demographics and clinical information related to MALA were abstracted...
July 10, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28688307/the-current-situation-of-inorganic-elements-in-marine-turtles-a-general-review-and-meta-analysis
#20
REVIEW
Adriana A Cortés-Gómez, Diego Romero, Marc Girondot
Inorganic elements (Pb, Cd, Hg, Al, As, Cr, Cu, Fe, Mn, Ni, Se and Zn) are present globally in aquatic systems and their potential transfer to marine turtles can be a serious threat to their health status. The environmental fate of these contaminants may be traced by the analysis of turtle tissues. Loggerhead turtles (Caretta caretta) are the most frequently investigated of all the sea turtle species with regards to inorganic elements, followed by Green turtles (Chelonia mydas); all the other species have considerably fewer studies...
July 5, 2017: Environmental Pollution
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