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https://www.readbyqxmd.com/read/27898991/nipple-and-areola-sparing-mastectomy-for-the-treatment-of-breast-cancer
#1
REVIEW
Bruna S Mota, Rachel Riera, Marcos Desidério Ricci, Jessica Barrett, Tiago B de Castria, Álvaro N Atallah, Jose Luiz B Bevilacqua
BACKGROUND: The efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of breast cancer are still questionable. It is estimated that the local recurrence rates following nipple-sparing mastectomy are very similar to breast-conserving surgery followed by radiotherapy. OBJECTIVES: To assess the efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of ductal carcinoma in situ and invasive breast cancer in women...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27867298/prophylactic-bilateral-nipple-sparing-mastectomy-and-a-staged-breast-reconstruction-technique-preliminary-results
#2
Thierry Tondu, Filip Thiessen, Wiebren A A Tjalma
More high-risk women with breast cancer are identified using genetic testing at a younger age. These young women often opt for prophylactic surgery. Most patients are reluctant for extra donor-site scars besides infections and necrosis. In order to reduce these risks, a two-stage breast reconstruction technique is used for high-risk women with large or ptotic breasts. We presume that this procedure will reduce the risk of skin envelope and nipple-areola complex (NAC) necrosis to less than 1%. In the first stage, an inferior pedicle reduction is performed to obtain large volume reduction with maximal safety for the NAC...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27866726/trends-in-mastectomy-and-reconstruction-for-breast-cancer-a-twelve-year-experience-from-a-tertiary-care-center
#3
James M Chang, Heidi E Kosiorek, Amylou C Dueck, William J Casey, Alanna M Rebecca, Raman Mahabir, Samir H Patel, Sameer R Keole, William W Wong, Carlos E Vargas, Michele Y Halyard, Richard J Gray, Nabil Wasif, Chee-Chee H Stucky, Barbara A Pockaj
BACKGROUND: Many surgical options exist for breast cancer, including breast conserving therapy (BCT), mastectomy with reconstruction (MAST+RECON) or without reconstruction (MAST). Long-term results regarding oncologic outcomes are few and primarily retrospective studies. METHODS: A retrospective review of a prospectively collected database of patients undergoing breast surgery for breast cancer from 2002 to 2014 was performed. Patients were separated into 3 time periods for analysis: 2002 to 2005, 2006 to 2009, and 2010 to 2014...
September 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27848910/-the-pitfalls-of-necrotising-soft-tissue-infection-a-wake-up-call-for-surgeons
#4
V M de Jong, J C Goslings
Necrotising soft tissue infections require early consultation of an experienced surgeon, regardless of what time of day they occur. Delays in diagnosis and treatment should not occur. Necrotectomy should be skin-sparing when possible. A low threshold for consultation with a tertiary referral center is recommended.
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27837296/comparison-of-local-recurrence-after-simple-and-skin-sparing-mastectomy-performed-in-patients-with-ductal-carcinoma-in-situ
#5
Simon Timbrell, Sarah Al-Himdani, Oliver Shaw, Kian Tan, Julie Morris, Nigel Bundred
BACKGROUND: The incidence of ductal carcinoma in situ (DCIS) is increasing with the use of screening mammography, and approximately 30% of all women diagnosed with DCIS are treated by mastectomy. There is increasing use of a skin-sparing mastectomy (SSM) approach to surgically excise DCIS as this facilitates immediate breast reconstruction. The rates of locoregional recurrence (LRR) after simple mastectomy performed for pure DCIS are historically reported as 1%; however, international data suggest that LRR after SSM may be higher...
November 11, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27817227/-evaluation-of-clinicopathological-findings-and-cosmetic-outcome-of-100-immediate-postmastectomy-breast-reconstruction-cases
#6
Dávid Pukancsik, Péter Kelemen, Ákos Sávolt, Mihály Újhelyi, Eszter Kovács, Zoltán Zaka, Miklós Kásler, Zoltán Mátrai
INTRODUCTION: Immediate breast reconstruction provides oncological safety, requires longer operation time. It does not influence the initiation of adjuvant therapy and radiological control, and results in favourable cosmetic outcome. AIM: Assessing the Hungarian data of immediate postmastectomy breast reconstructions, and comparing them to international findings. METHOD: Between May, 2011 and September, 2014 121 therapeutic and prophylactic, postmastectomy immediate breast reconstructions were performed in 100 patients...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27730018/aesthetic-outcomes-of-inframammary-fold-recreation-in-two-stage-implant-based-breast-reconstruction
#7
Koichi Tomita, Kenji Yano, Akimitsu Nishibayashi, Shien Seike, Ko Hosokawa
BACKGROUND: When the inframammary fold (IMF) is excised in mastectomy procedures for oncologic reasons, it must be recreated to restore a natural breast shape. Despite refinements in surgical techniques, postoperative loss of a well-defined IMF can occur. This study aimed to assess the outcomes of IMF recreation after two-stage, implant-based breast reconstruction. METHODS: We retrospectively reviewed 75 consecutive patients who underwent unilateral, two-stage, implant-based breast reconstruction between 2013 and 2015 at the authors' institution...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27692794/outcomes-and-feasibility-of-nipple-sparing-mastectomy-for-node-positive-breast-cancer-patients
#8
Brittany L Murphy, Tanya L Hoskin, Judy C Boughey, Amy C Degnim, James W Jakub, Adam C Krajewski, Steven R Jacobson, Tina J Hieken
BACKGROUND: While nipple-sparing mastectomy (NSM) is gaining acceptance for risk reduction and for treatment of early stage breast cancer, node-positive disease remains a relative contraindication. Our aim was to evaluate the use and outcomes of NSM in node-positive breast cancer patients. METHODS: We identified 240 cancers in 226 patients (14 bilateral) scheduled for NSM and operated on between 1/2009 and 6/2014. We compared outcomes for 58 node-positive vs 182 node-negative patients...
September 3, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27675969/a-phase-iii-randomized-control-trial-comparing-skin-sparing-helical-tomotherapy-versus-3d-conformal-radiation-therapy-in-early-stage-breast-cancer-acute-and-late-skin-toxicity-outcomes
#9
B S Abdulkarim, K Joseph, L Vos, H K Warkentin, Z Gabos, N Pervez, K Tankel, S Ghosh, S M J Chafe, M B Parliament
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674803/radiation-therapy-outcomes-after-skin-sparing-mastectomy-and-implant-based-breast-reconstruction
#10
S Yuce Sari, A Kotek, M Gultekin, B Akkus Yildirim, C Onal, G Ozyigit, M Gurkaynak, F Yildiz
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27672716/one-stage-placement-of-permanent-implant-compared-to-two-stage-tissue-expander-reconstruction
#11
Wendy K Y Ng, Amy Chesney, Forough Farrokhyar, Nicole Hodgson, Arianna Dal Cin
With the advent of the skin sparing mastectomy, immediate breast reconstruction with placement of the definitive prosthesis at the time of mastectomy is possible. The question remains: does single-stage prosthetic reconstruction result in greater numbers of complications or rates of re-operation, compared to two-stage tissue expander reconstruction? A retrospective cohort study of a single centre?s experience with these techniques was carried out. From 2004 to 2012, 54 cases of immediate breast reconstruction with implant were identified, and 108 cases of immediate breast reconstruction using a tissue expander were identified...
September 27, 2016: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/27620883/trends-and-variation-in-the-use-of-nipple-sparing-mastectomy-for-breast-cancer-in-the-united-states
#12
Mark Sisco, Alexandra M Kyrillos, Brittany R Lapin, Chihsiung E Wang, Katharine A Yao
PURPOSE: For many women, nipple-sparing mastectomy (NSM) provides aesthetic and quality-of-life outcomes superior to skin-sparing mastectomy. Accumulating data suggest that NSM provides similar oncologic outcomes in select breast cancer patients. This study sought to determine national trends in NSM use. METHODS: Using the National Cancer Data Base, 6254 women with breast cancer who underwent NSM between 2010 and 2013 were identified. NSM rates were determined relative to the number of patients who received a mastectomy with reconstruction (n = 114,849)...
November 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27612282/postoperative-radiation-therapy-after-nipple-sparing-or-skin-sparing-mastectomy-a-survey-of-european-north-american-and-south-american-practices
#13
Gustavo Nader Marta, Philip M Poortmans, Thomas A Buchholz, Tarek Hijal
Skin sparing mastectomy, a surgical procedure sparing a large portion of the overlying skin of the breast, and nipple-sparing mastectomy, sparing the whole nipple-areolar complex, are increasingly used, although their oncologic efficacy remains unclear. The aim of this study was to assess the radiation oncologists' opinions regarding the indications of radiation therapy (RT) after skin-sparing mastectomy and nipple-sparing mastectomy. Radiation oncology members of four national and international societies were invited to complete a questionnaire comprising of 22 questions to assess their opinions regarding RT indications in the context of skin-sparing and nipple-sparing mastectomy...
September 9, 2016: Breast Journal
https://www.readbyqxmd.com/read/27563563/breast-reconstruction-at-the-md-anderson-cancer-center
#14
REVIEW
Peirong Yu
The introduction of the transverse rectus abdominis myocutaneous flap in the 1970s marks the beginning of modern breast reconstruction although implants were available even earlier mainly for breast augmentation. Mastectomy techniques have evolved from the early Halsted radical mastectomy to the modern skin sparing mastectomy. The latter made possible using implants for breast reconstruction. Although prosthetic reconstruction provides a simpler procedure with quick recovery, autologous reconstruction offers more natural and long-lasting results especially in the setting of radiotherapy...
August 2016: Gland Surgery
https://www.readbyqxmd.com/read/27556624/skin-sparing-d%C3%A3-bridement-for-necrotizing-fasciitis-in-children
#15
Magali S Rüfenacht, Ernesto Montaruli, Eléonore Chappuis, Klara M Posfay-Barbe, Giorgio C La Scala
BACKGROUND: Necrotizing fasciitis is a serious soft-tissue infection associated with sepsis and tissue destruction. Surgical management usually requires extensive débridement of necrotic fascia and overlying skin, with significant aesthetic and functional consequences. The authors review the outcome of all recent cases of necrotizing fasciitis treated with skin-sparing débridement at their institution. METHODS: The authors conducted a retrospective review of all of their cases of necrotizing fasciitis treated with skin-sparing débridement...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27556599/is-single-stage-prosthetic-reconstruction-cost-effective-a-cost-utility-analysis-for-the-use-of-direct-to-implant-breast-reconstruction-relative-to-expander-implant-reconstruction-in-postmastectomy-patients
#16
Naveen M Krishnan, John P Fischer, Marten N Basta, Maurice Y Nahabedian
BACKGROUND: Prosthetic breast reconstruction is most commonly performed using the two-stage (expander-implant) technique. However, with the advent of skin-sparing mastectomy and the use of acellular dermal matrices, one-stage prosthetic reconstruction has become more feasible. Prior studies have suggested that one-stage reconstruction has economic advantages relative to two-stage reconstruction despite a higher revision rate. This is the first cost-utility analysis to compare the cost and quality of life of both procedures to guide patient care...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27536498/initial-experience-using-closed-incision-negative-pressure-therapy-after-immediate-postmastectomy-breast-reconstruction
#17
Allen Gabriel, Steven R Sigalove, G Patrick Maxwell
Although immediate postmastectomy breast reconstruction is favored over delayed reconstruction, it remains associated with high complication rates. Potential complications include seroma formation, dehiscence, infection, and tissue necrosis along incision edges. Closed incision negative pressure therapy (ciNPT; Prevena Incision Management System, KCI, an Acelity company, San Antonio, Tex.) has been reported to help hold incision edges together, protect incisions from external contamination, and remove fluid and infectious material...
July 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27521042/contemporary-operative-management-of-t4-breast-cancer
#18
Brittany L Murphy, Tanya L Hoskin, Judy C Boughey, Amy C Degnim, Jodi M Carter, Katrina N Glazebrook, Tina J Hieken
BACKGROUND: Guidelines advise modified radical mastectomy following neoadjuvant systemic therapy for T4 breast cancer. We studied the influence of current systemic therapy and tumor subtype on pathologic stage and practice patterns to identify patients for whom less aggressive operative treatment might be considered. METHODS: We identified 98 clinical T4 M0 cases operated on at our institution from October 2008-July 2015. Patient, tumor, and treatment variables were analyzed...
October 2016: Surgery
https://www.readbyqxmd.com/read/27394682/ethyl-cellulose-nanocarriers-and-nanocrystals-differentially-deliver-dexamethasone-into-intact-tape-stripped-or-sodium-lauryl-sulfate-exposed-ex-vivo-human-skin-assessment-by-intradermal-microdialysis-and-extraction-from-the-different-skin-layers
#19
Nadine Döge, Stefan Hönzke, Fabian Schumacher, Benjamin Balzus, Miriam Colombo, Sabrina Hadam, Fiorenza Rancan, Ulrike Blume-Peytavi, Monika Schäfer-Korting, Anke Schindler, Eckart Rühl, Per Stahl Skov, Martin K Church, Sarah Hedtrich, Burkhard Kleuser, Roland Bodmeier, Annika Vogt
Understanding penetration not only in intact, but also in lesional skin with impaired skin barrier function is important, in order to explore the surplus value of nanoparticle-based drug delivery for anti-inflammatory dermatotherapy. Herein, short-term ex vivo cultures of (i) intact human skin, (ii) skin pretreated with tape-strippings and (iii) skin pre-exposed to sodium lauryl sulfate (SLS) were used to assess the penetration of dexamethasone (Dex). Intradermal microdialysis was utilized for up to 24h after drug application as commercial cream, nanocrystals or ethyl cellulose nanocarriers applied at the therapeutic concentration of 0...
July 6, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27382401/experience-with-bilateral-risk-reducing-mastectomy-for-an-unaffected-brca-mutation-carrier
#20
Yurina Maeshima, Kumiko Oseto, Ryohei Katsuragi, Yukiko Yoshimoto, Sachiko Takahara, Akira Yamauchi
Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compared with intensive surveillance. The oncological risk associated with the presence of remnant breast glandular tissue after SSM or nipple-sparing mastectomy has been obscure...
June 2016: Journal of Breast Cancer
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