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https://www.readbyqxmd.com/read/28338306/implantation-of-a-biodegradable-rectum-balloon-implant-tips-tricks-and-pitfalls
#1
Ben G L Vanneste, Kees van De Beek, Ludy Lutgens, Philippe Lambin
INTRODUCTION: A rectum balloon implant (RBI) is a new device to spare rectal structures during prostate cancer radiotherapy. The theoretical advantages of a RBI are to reduce the high radiation dose to the anterior rectum wall, the possibility of a post-implant correction, and their predetermined shape with consequent predictable position. OBJECTIVE: To describe, step-by-step, our mini-invasive technique for hands-free transperineal implantation of a RBI before start of radiotherapy treatment...
March 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28333309/positive-margin-re-excision-following-immediate-autologous-breast-reconstruction-morbidity-cosmetic-outcome-and-oncologic-significance
#2
Oscar Ochoa, Constantine Theoharis, Steven Pisano, Minas Chrysopoulo, Peter Ledoux, Gary Arishita, Chet Nastala
Background: Acquisition of negative resection margins is paramount in the surgical management of operable breast cancer. Management of positive margins following mastectomy and immediate breast reconstruction is presently poorly defined. Objectives: The present study aims at defining morbidity and cosmetic sequela of re-excision procedures aimed at clearing involved mastectomy margins in the setting of immediate autologous breast reconstruction. Oncologic outcomes are recorded...
March 17, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28319637/online-patient-reported-reviews-of-mohs-micrographic-surgery-qualitative-analysis-of-positive-and-negative-experiences
#3
Shuai Xu, Zaza Atanelov, Ashish C Bhatia
Mohs micrographic surgery (MMS) is the gold standard for treating high-risk skin cancers and skin cancers in areas where skin sparing is essential. However, relatively little is known about patient-reported satisfaction with this procedure. In this study, we used qualitative research methods to determine themes of patient-reported satisfaction and dissatisfaction with MMS on one popular online resource (RealSelf). Real-world patient feedback provides an opportunity for physicians to explore the patient mind-set and to target areas of potential improvement in MMS patient satisfaction...
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28319433/breast-reconstruction-following-nipple-sparing-mastectomy-clinical-outcomes-and-risk-factors-related-complications
#4
Rosaria Laporta, Benedetto Longo, Michail Sorotos, Alessio Farcomeni, Caterina Patti, Maria Rosaria Mastrangeli, Corrado Rubino, Fabio Santanelli di Pompeo
BACKGROUND: The aim of this study was to investigate clinical outcomes and risk factors related complications in patients who had undergone nipple-sparing mastectomy (NSM) followed by implant-based or autologous reconstruction. METHODS: Between 2004-2014 a single-institution retrospective review was collected on NSMs reconstruction. Patient demographics, comorbidities, breast morphological factors, type and timing of radiotherapy, type of incision, reconstruction type and timing, implant volume and complications were collected...
March 20, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28301045/beneficial-effect-of-ustekinumab-in-familial-pityriasis-rubra-pilaris-with-a-new-missense-mutation-in-card14
#5
S M Lwin, C-K Hsu, L Liu, H-Y Huang, N J Levell, J A McGrath
Pityriasis rubra pilaris (PRP) represents a group of rare chronic inflammatory skin disorders in which ~1 in 20 affected individuals show autosomal dominant inheritance. In such cases, there may be gain-of-function mutations in CARD14, encoding caspase recruitment domain-containing protein 14 (CARD14) that activates the non-canonical nuclear factor-kappa B (NF-κB) pathway, thereby promoting cutaneous inflammation. Here, we report a mother and son with PRP due to a new missense mutation in CARD14 and describe the beneficial clinical effects of ustekinumab, a monoclonal antibody against interleukins-12 and -23, in both subjects...
March 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28298846/menkes-disease-and-response-to-copper-histidine-an-indian-case-series
#6
Sangeetha Yoganathan, Sniya Valsa Sudhakar, Gautham Arunachal, Maya Thomas, Annadurai Subramanian, Renu George, Sumita Danda
BACKGROUND: Menkes disease (MD) is an X-linked recessive neurodegenerative disorder caused by mutations in ATP7A gene. Depending on the residual ATP7A activity, manifestation may be classical MD, occipital horn syndrome, or distal motor neuropathy. Neurological sparing is expected in female carriers. However, on rare occasions, females may manifest with classical clinical phenotype due to skewed X-chromosome inactivation, X-autosome translocation, and XO genotype. Here, we describe a small series of probands with MD and their response to copper histidine therapy...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28297282/volumetric-modulated-arc-therapy-using-multicriteria-optimization-for-body-and-extremity-sarcoma
#7
Michael R Young, David L Craft, Caroline M Colbert, Kyla Remillard, Liam Vanbenthuysen, Yi Wang
This study evaluates the implementation of volumetric-modulated arc therapy (VMAT) using multicriteria optimization (MCO) in the RayStation treatment planning system (TPS) for complex sites, namely extremity and body sarcoma. The VMAT-MCO algorithm implemented in RayStation is newly developed and requires an integrated, comprehensive analysis of plan generation, delivery, and treatment efficiency. Ten patients previously treated by intensity-modulated radiation therapy (IMRT) with MCO were randomly selected and replanned using VMAT-MCO...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28293497/vertically-set-sombrero-shaped-abdominal-flap-for-asian-breast-reconstruction-after-skin-sparing-mastectomy
#8
Hirokazu Uda, Kotaro Yoshimura, Rintaro Asahi, Syunji Sarukawa, Ataru Sunaga, Hideaki Kamochi, Yasushi Sugawara
BACKGROUND: Immediate autologous breast reconstruction after skin-sparing mastectomy is an esthetically superior method, and a free abdominal flap is often used. However, in Asian patients, little redundant abdominal skin and thin subcutaneous tissue are common, necessitating the development of a more suitable flap design and setting. We devised a narrow flap, the sombrero-shaped flap (S-flap), set vertically, to reduce postoperative abdominal morbidity without sacrificing cosmetic results...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28286109/bullous-pemphigoid
#9
REVIEW
Işın Sinem Bağcı, Orsolya N Horváth, Thomas Ruzicka, Miklós Sárdy
Bullous pemphigoid (BP) is the most common autoimmune bullous disorder which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. Collagen XVII and dystonin-e have been identified as target antigens. BP affects mostly the elderly. The incidence of the disease is increasing gradually and is associated with high morbidity and mortality. Clinically, BP is characterized by an intensely pruritic eruption with widespread bullous lesions. The clinical diagnosis can be challenging in the setting of atypical presentations...
March 8, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28281862/model-based-approach-for-quantitative-estimates-of-skin-heart-and-lung-toxicity-risk-for-left-side-photon-and-proton-irradiation-after-breast-conserving-surgery
#10
Francesco Tommasino, Marco Durante, Vittoria D'Avino, Raffaele Liuzzi, Manuel Conson, Paolo Farace, Giuseppe Palma, Marco Schwarz, Laura Cella, Roberto Pacelli
BACKGROUND: Proton beam therapy represents a promising modality for left-side breast cancer (BC) treatment, but concerns have been raised about skin toxicity and poor cosmesis. The aim of this study is to apply skin normal tissue complication probability (NTCP) model for intensity modulated proton therapy (IMPT) optimization in left-side BC. MATERIAL AND METHODS: Ten left-side BC patients undergoing photon irradiation after breast-conserving surgery were randomly selected from our clinical database...
March 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28269132/kinect2-respiratory-movement-detection-study
#11
Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad
Radiotherapy is one of the main cancer treatments. It consists in irradiating tumor cells to destroy them while sparing healthy tissue. The treatment is planned based on Computed Tomography (CT) and is delivered over fractions during several days. One of the main challenges is replacing patient in the same position every day to irradiate the tumor volume while sparing healthy tissues. Many patient positioning techniques are available. They are both invasive and not accurate performed using tattooed marker on the patient's skin aligned with a laser system calibrated in the treatment room or irradiating using X-ray...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260139/the-impact-of-mastectomy-type-on-the-female-sexual-function-index-fsfi-satisfaction-with-appearance-and-the-reconstructed-breast-s-role-in-intimacy
#12
K Rojas, M Onstad, C Raker, M A Clark, A Stuckey, J Gass
BACKGROUND: As mastectomy rates increase and overall survival for early breast cancer improves, a better understanding of the long-term consequences of mastectomy is needed. We sought to explore the correlation of specific mastectomy type with the Female Sexual Function Index (FSFI), body image satisfaction, and the reconstructed breast's role in intimacy. METHODS: This study is a secondary analysis of a cross-sectional survey including a retrospective chart review...
March 4, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28256637/ebola-virus-infection-kinetics-in-chimeric-mice-reveal-a-key-role-of-t-cells-as-barriers-for-virus-dissemination
#13
Anja Lüdtke, Paula Ruibal, David M Wozniak, Elisa Pallasch, Stephanie Wurr, Sabrina Bockholt, Sergio Gómez-Medina, Xiangguo Qiu, Gary P Kobinger, Estefanía Rodríguez, Stephan Günther, Susanne Krasemann, Juliana Idoyaga, Lisa Oestereich, César Muñoz-Fontela
Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates characterized by high levels of viremia and virus titers in peripheral organs. The natural portals of virus entry are the mucosal surfaces and the skin where macrophages and dendritic cells (DCs) are primary EBOV targets. Due to the migratory properties of DCs, EBOV infection of these cells has been proposed as a necessary step for virus dissemination via draining lymph nodes and blood. Here we utilize chimeric mice with competent hematopoietic-driven immunity, to show that EBOV primarily infects CD11b(+) DCs in non-lymphoid and lymphoid tissues, but spares the main cross-presenting CD103(+) DC subset...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256398/influence-of-exposure-and-geometric-parameters-on-absorbed-doses-associated-with-common-neuro-interventional-procedures
#14
Mohammad Javad Safari, Jeannie Hsiu Ding Wong, Wei Loong Jong, Nathan Thorpe, Dean Cutajar, Anatoly Rosenfeld, Kwan Hoong Ng
PURPOSE: The purpose of this study was to investigate the effects of routine exposure parameters on patient's dose during neuro-interventional radiology procedures. METHODS: We scrutinized the routine radiological exposure parameters during 58 clinical neuro-interventional procedures such as, exposure direction, magnification, frame rate, and distance between image receptor to patient's body and evaluate their effects on patient's dose using an anthropomorphic phantom...
February 27, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28240741/genetic-ablation-of-ginip-expressing-primary-sensory-neurons-strongly-impairs-formalin-evoked-pain
#15
Louise Urien, Stéphane Gaillard, Laure Lo Re, Pascale Malapert, Manon Bohic, Ana Reynders, Aziz Moqrich
Primary sensory neurons are heterogeneous by myriad of molecular criteria. However, the functional significance of this remarkable heterogeneity is just emerging. We precedently described the GINIP(+) neurons as a new subpopulation of non peptidergic C-fibers encompassing the free nerve ending cutaneous MRGPRD(+) neurons and C-LTMRs. Using our recently generated ginip mouse model, we have been able to selectively ablate the GINIP(+) neurons and assess their functional role in the somatosensation. We found that ablation of GINIP(+) neurons affected neither the molecular contents nor the central projections of the spared neurons...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239778/-minimally-invasive-bypass-surgery-for-nasolacrimal-duct-obstruction-transcanalicular-laser-assisted-dacryocystorhinostomy
#16
K R Koch, C Cursiefen, L M Heindl
BACKGROUND: In recent years, the minimally invasive surgical procedure of transcanalicular laser-assisted dacryocystorhinostomy (TKL-DCR) has gained importance in the treatment of primary acquired nasolacrimal duct obstructions (PANDO). OBJECTIVES: Surgical indications, functional success rates, potential advantages, and complications of TKL-DCR are presented and compared with the standard procedures external (EXT-DCR) and endonasal DCR (EN-DCR). METHODS: The study comprises a PubMed literature review and our own clinical results...
February 26, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28229637/a-simple-standard-technique-for-labyrinthectomy-in-the-rat-a-methodical-communication-with-a-detailed-description-of-the-surgical-process
#17
G L Nádasy, G Raffai, E Fehér, G Schaming, E Monos
Aims Labyrinthectomized rats are suitable models to test consequences of vestibular lesion and are widely used to study neural plasticity. We describe a combined microsurgical-chemical technique that can be routinely performed with minimum damage. Methods Caudal leaflet of the parotis is elevated. The tendinous fascia covering the bulla is opened frontally from the sternomastoid muscle's tendon while sparing facial nerve branches. A 4 mm diameter hole is drilled into the bulla's hind lower lateral wall to open the common (in rodents) mastoid-tympanic cavity...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28227361/kinect2-respiratory-movement-detection-study
#18
Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad, Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad, Sandy Rihana, Elie Younes, Dimitris Visvikis, Hadi Fayad
Radiotherapy is one of the main cancer treatments. It consists in irradiating tumor cells to destroy them while sparing healthy tissue. The treatment is planned based on Computed Tomography (CT) and is delivered over fractions during several days. One of the main challenges is replacing patient in the same position every day to irradiate the tumor volume while sparing healthy tissues. Many patient positioning techniques are available. They are both invasive and not accurate performed using tattooed marker on the patient's skin aligned with a laser system calibrated in the treatment room or irradiating using X-ray...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28215734/clinical-experiences-with-the-use-of-ultrapro-%C3%A2-mesh-in-single-stage-direct-to-implant-immediate-postmastectomy-breast-reconstruction-in-102-patients-a-retrospective-cohort-study
#19
D Pukancsik, P Kelemen, G Gulyás, M Újhelyi, E Kovács, K Éles, N Mészáros, I Kenessey, P Pálházi, T Kovács, M Kásler, Z Mátrai
BACKGROUND: Acellular dermal matrices have been used for direct-to-implant (DTI) breast reconstruction (BR), eliminating the load of the lower pole skin envelope. However, the available allograft matrices add considerable health care costs. This study examined the long-term follow-up of synthetic ULTRAPRO(®) mesh as a low-cost potential alternative to biological matrices. PATIENTS AND METHODS: A retrospective cohort study was performed between January 2013 and January 2016, involved 112 early-stage breast cancer and/or BRCA 1/2 patients, and evaluated 189 immediate DTI BRs following skin-, areola- or nipple-sparing mastectomy using ULTRAPRO(®) mesh...
February 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28210544/cataracts-and-strabismus-associated-with-hand-rearing-using-artificial-milk-formulas-in-bengal-tiger-panthera-tigris-spp-tigris-cubs
#20
Rogério Ribas Lange, Leandro Lima, Erika Frühvald, Vera Sônia Nunes da Silva, Aparecida Sônia de Souza, Fabiano Montiani-Ferreira
The aim of this investigation is to describe the potential contributing nutritional factors involved in the development of ophthalmic and dermatologic changes in four Bengal tiger (Panthera tigris spp tigris) cubs fed an artificial milk formula. The affected animals were compared with two other tiger cubs that had been nursed by their dam naturally. After the first clinical signs appeared, the tiger cubs underwent ophthalmic evaluation. Severe symmetric generalized alopecia over the trunk, sparing the head and distal portion of the front and rear limbs, bilateral cataracts and strabismus were noticed...
2017: Open veterinary journal
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