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https://www.readbyqxmd.com/read/27898991/nipple-and-areola-sparing-mastectomy-for-the-treatment-of-breast-cancer
#1
REVIEW
Bruna S Mota, Rachel Riera, Marcos Desidério Ricci, Jessica Barrett, Tiago B de Castria, Álvaro N Atallah, Jose Luiz B Bevilacqua
BACKGROUND: The efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of breast cancer are still questionable. It is estimated that the local recurrence rates following nipple-sparing mastectomy are very similar to breast-conserving surgery followed by radiotherapy. OBJECTIVES: To assess the efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of ductal carcinoma in situ and invasive breast cancer in women...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27898429/dosimetric-improvements-with-a-novel-breast-stereotactic-radiotherapy-device-for-delivery-of-preoperative-partial-breast-irradiation
#2
James W Snider Iii, Yildirim Mutaf, Elizabeth Nichols, Andrea Hall, Patrick Vadnais, William F Regine, Steven J Feigenberg
OBJECTIVE: Partial-breast irradiation (PBI) with external-beam radiotherapy has produced higher than expected rates of fair-to-poor cosmesis. Worsened outcomes have been correlated with larger volumes of breast tissue exposed to radiation. A novel breast-specific stereotactic radiotherapy (BSRT) device (BSRTD) has been developed at our institution and has shown promise in delivering highly conformal dose distributions. We compared normal tissue sparing with this device with that achieved with intensity-modulated radiation therapy (IMRT)-PBI...
November 30, 2016: Oncology
https://www.readbyqxmd.com/read/27886405/hypercalcemia-in-necrobiotic-xanthogranuloma-first-reported-case-and-insight-into-treatment
#3
Jad G Sfeir, Richard J Zogala, Violeta B Popii
Necrobiotic Xanthogranuloma (NXG) is a rare systemic and progressive granulomatous disease first described in 1980. Given no established first-line therapy, treatment focuses on the control of skin lesions and associated complications. Despite it being a granulomatous disease, NXG has not been associated with hypercalcemia. About 140 cases of NXG have been reported to-date but, to our knowledge, this is the first case to be complicated by hypercalcemia. Our case confirms a granulomatous disease mediated production of 1α-hydroxylase leading to increased synthesis of 1,25-dihydroxyvitamin D and subsequent hypercalcemia...
November 25, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27878058/patient-factors-and-their-association-with-nonmelanoma-skin-cancer-morbidity-and-the-performance-of-self-skin-exams-a-cross-sectional-study
#4
Kyle T Amber, Romi Bloom, Mohammad-Ali Yazdani Abyaneh, Leyre A Falto-Aizpurua, Martha Viera, Martin N Zaiac, Keyvan Nouri, Shasa Hu
Objective: Mohs micrographic surgery is widely utilized for the treatment of nonmelanoma skin cancers with the advantage of tissue sparing and higher cure rate. The preoperative tumor size and post-Mohs micrographic surgery defect size are useful surrogate measures of nonmelanoma skin cancer morbidity. The authors sought to evaluate whether gender, Hispanic ethnicity, socioeconomic status, sun-safe practices and self-skin exams affected tumor size and Mohs micrographic surgery defect size. They also investigated factors associated with self-skin exams...
September 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27867298/prophylactic-bilateral-nipple-sparing-mastectomy-and-a-staged-breast-reconstruction-technique-preliminary-results
#5
Thierry Tondu, Filip Thiessen, Wiebren A A Tjalma
More high-risk women with breast cancer are identified using genetic testing at a younger age. These young women often opt for prophylactic surgery. Most patients are reluctant for extra donor-site scars besides infections and necrosis. In order to reduce these risks, a two-stage breast reconstruction technique is used for high-risk women with large or ptotic breasts. We presume that this procedure will reduce the risk of skin envelope and nipple-areola complex (NAC) necrosis to less than 1%. In the first stage, an inferior pedicle reduction is performed to obtain large volume reduction with maximal safety for the NAC...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27866726/trends-in-mastectomy-and-reconstruction-for-breast-cancer-a-twelve-year-experience-from-a-tertiary-care-center
#6
James M Chang, Heidi E Kosiorek, Amylou C Dueck, William J Casey, Alanna M Rebecca, Raman Mahabir, Samir H Patel, Sameer R Keole, William W Wong, Carlos E Vargas, Michele Y Halyard, Richard J Gray, Nabil Wasif, Chee-Chee H Stucky, Barbara A Pockaj
BACKGROUND: Many surgical options exist for breast cancer, including breast conserving therapy (BCT), mastectomy with reconstruction (MAST+RECON) or without reconstruction (MAST). Long-term results regarding oncologic outcomes are few and primarily retrospective studies. METHODS: A retrospective review of a prospectively collected database of patients undergoing breast surgery for breast cancer from 2002 to 2014 was performed. Patients were separated into 3 time periods for analysis: 2002 to 2005, 2006 to 2009, and 2010 to 2014...
September 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27848910/-the-pitfalls-of-necrotising-soft-tissue-infection-a-wake-up-call-for-surgeons
#7
V M de Jong, J C Goslings
Necrotising soft tissue infections require early consultation of an experienced surgeon, regardless of what time of day they occur. Delays in diagnosis and treatment should not occur. Necrotectomy should be skin-sparing when possible. A low threshold for consultation with a tertiary referral center is recommended.
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27837296/comparison-of-local-recurrence-after-simple-and-skin-sparing-mastectomy-performed-in-patients-with-ductal-carcinoma-in-situ
#8
Simon Timbrell, Sarah Al-Himdani, Oliver Shaw, Kian Tan, Julie Morris, Nigel Bundred
BACKGROUND: The incidence of ductal carcinoma in situ (DCIS) is increasing with the use of screening mammography, and approximately 30% of all women diagnosed with DCIS are treated by mastectomy. There is increasing use of a skin-sparing mastectomy (SSM) approach to surgically excise DCIS as this facilitates immediate breast reconstruction. The rates of locoregional recurrence (LRR) after simple mastectomy performed for pure DCIS are historically reported as 1%; however, international data suggest that LRR after SSM may be higher...
November 11, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27829609/pharmacokinetic-studies-of-gel-system-containing-ibuprofen-solid-nanoparticles
#9
Noriaki Nagai, Tadatoshi Tanino, Yoshimasa Ito
In the therapy of rheumatoid arthritis, ibuprofen (IBU) is widely used; however, it has been limited the clinical use by its systemic side effect, such as gastrointestinal lesions. Therefore, we prepared topical gel ointment used IBU solid nanoparticles (IBUnano-gel formulation). In addition, we demonstrated their anti-inflammatory effect by using arthritis model rat (adjuvant-induced arthritis rat, AA rat). The gel formulations were prepared using additives (Carbopol 934, 2-hydroxypropyl-β-cyclodextrin and methylcellulose) and bead mill-method...
December 1, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27824918/skin-vaccination-against-rotavirus-using-microneedles-proof-of-concept-in-gnotobiotic-piglets
#10
Yuhuan Wang, Anastasia Vlasova, Daniel E Velasquez, Linda J Saif, Sukumar Kandasamy, Efrat Kochba, Yotam Levin, Baoming Jiang
Live-attenuated oral rotavirus (RV) vaccines have lower efficacy in low income countries, and additionally are associated with a rare but severe adverse event, intussusception. We have been pursuing the development of an inactivated rotavirus vaccine (IRV) using the human rotavirus strain CDC-9 (G1P[8]) through parenteral immunization and previously demonstrated dose sparing and enhanced immunogenicity of intradermal (ID) unadjuvanted IRV using a coated microneedle patch in comparison with intramuscular (IM) administration in mice...
2016: PloS One
https://www.readbyqxmd.com/read/27817227/-evaluation-of-clinicopathological-findings-and-cosmetic-outcome-of-100-immediate-postmastectomy-breast-reconstruction-cases
#11
Dávid Pukancsik, Péter Kelemen, Ákos Sávolt, Mihály Újhelyi, Eszter Kovács, Zoltán Zaka, Miklós Kásler, Zoltán Mátrai
INTRODUCTION: Immediate breast reconstruction provides oncological safety, requires longer operation time. It does not influence the initiation of adjuvant therapy and radiological control, and results in favourable cosmetic outcome. AIM: Assessing the Hungarian data of immediate postmastectomy breast reconstructions, and comparing them to international findings. METHOD: Between May, 2011 and September, 2014 121 therapeutic and prophylactic, postmastectomy immediate breast reconstructions were performed in 100 patients...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27817209/sarcoidosis-an-update-on-current-pharmacotherapy-options-and-future-directions
#12
Pilar Brito-Zerón, Roberto Pérez-Alvarez, Lucio Pallarés, Soledad Retamozo, Robert P Baughman, Manuel Ramos-Casals
Sarcoidosis is a systemic disease of unknown etiology characterized by the development of non-caseating epitheloid granulomas. The lungs are the most commonly involved organ (> 90% of cases), followed by the lymph nodes, the skin, and the eyes. AREAS COVERED. This review summarizes current pharmacotherapy options and future directions for the development of new therapies. Glucocorticoids are the first-line therapy for sarcoidosis. For patients with the most severe forms of sarcoidosis (who will need glucocorticoids for long periods) and for those intolerant or refractory, immunosuppressive drugs are used as sparing agents...
November 7, 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27810700/robotic-nipple-sparing-mastectomy-for-the-treatment-of-breast-cancer-feasibility-and-safety-study
#13
Antonio Toesca, Nickolas Peradze, Andrea Manconi, Viviana Galimberti, Mattia Intra, Marco Colleoni, Bernardo Bonanni, Giuseppe Curigliano, Mario Rietjens, Giuseppe Viale, Virgilio Sacchini, Paolo Veronesi
BACKGROUND: We previously devised and reported on an innovative surgical technique of robotic nipple-sparing mastectomy and immediate robotic breast reconstruction. Here we describe the outcome of the first 29 such consecutive procedures performed on breast cancer patients to assess feasibility, reproducibility and safety. METHODS: The following morbidity factors were tested: operation time, conversion rate to open technique, length of hospitalization, registration of complications for 1 year postoperatively and their characterization as either minor, major, or multiple, depending on clinical severity and treatment required...
October 29, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27800186/modified-lower-pole-autologous-dermal-sling-for-implant-reconstruction-in-women-undergoing-immediate-breast-reconstruction-after-mastectomy
#14
Pankaj G Roy
Background. Autologous dermal sling with wise pattern skin reducing mastectomy allows one-stage implant reconstruction in women with large and ptotic breasts needing mastectomy for cancer or risk reduction. However, this technique is not suitable for women who lack ptosis and also carries risk of T-junction breakdown. Method. We have performed one-stage nipple sparing mastectomies with implant reconstruction in 5 women (8 breasts) by modifying the autologous dermal sling approach. All these women had small to moderate breasts with no ptosis or pseudoptosis...
2016: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/27793685/transcutaneous-immunization-via-rapidly-dissolvable-microneedles-protects-against-hand-foot-and-mouth-disease-caused-by-enterovirus-71
#15
Zhuangzhi Zhu, Xiaohua Ye, Zhiqiang Ku, Qingwei Liu, Chaoyun Shen, Huafei Luo, Hansen Luan, Chenghao Zhang, Shaoqiong Tian, CheeYen Lim, Zhong Huang, Hao Wang
Recent large outbreaks of hand-foot-and-mouth disease (HFMD) have seriously affected the health of young children. Enterovirus 71 (EV71) is the main causative agent of HFMD. Herein, for the first time, rapidly dissolvable microneedles (MNs) loaded with EV71 virus-like particles (VLPs) were evaluated whether they could induce robust immune responses that confer protection against EV71 infection. The characteristics of prepared MNs including hygroscopy, mechanical strength, insertion capacity, dissolution profile, skin irritation and storage stability were comprehensively assessed...
October 25, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27790562/toxicity-profile-of-imrt-vs-3d-crt-in-head-and-neck-cancer-a-retrospective-study
#16
Gopa Ghosh, Ramanjis Tallari, Anupam Malviya
INTRODUCTION: Role of radiotherapy in comprehensive management of head and neck cancer for achieving tumour control and organ preservation is now well established and radiotherapy is routinely used in adjuvant setting after surgery, concurrently with chemotherapy or targeted agents and for palliation. Development of linear accelerator with Multileaf Collimator (MLC) have revolutionized radiation delivery techniques, allowing conformal and Intensity Modulated Radiotherapy (IMRT) to deliver highly conformal sculpted radiation dose to a very complex structure with improved sparing of adjoining critical structures like salivary glands, spinal cord, eyes, brainstem and larynx amounting to better therapeutic gain...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785781/reflectance-confocal-microscopy-of-skin-in-vivo-from-bench-to-bedside
#17
Milind Rajadhyaksha, Ashfaq Marghoob, Anthony Rossi, Allan C Halpern, Kishwer S Nehal
Following more than two decades of effort, reflectance confocal microscopy (RCM) imaging of skin was granted codes for reimbursement by the US Centers for Medicare and Medicaid Services. Dermatologists in the USA have started billing and receiving reimbursement for the imaging procedure and for the reading and interpretation of images. RCM imaging combined with dermoscopic examination is guiding the triage of lesions into those that appear benign, which are being spared from biopsy, against those that appear suspicious, which are then biopsied...
October 27, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27784001/clinical-application-of-3d-printed-step-bolus-in-post-total-mastectomy-electron-conformal-therapy
#18
Kwangwoo Park, Sungjin Park, Mi-Jin Jeon, Jinhyun Choi, Jun Won Kim, Yoon Jin Cho, Won-Seok Jang, Yo Sup Keum, Ik Jae Lee
The 3D-printed boluses were used during the radiation therapy of the chest wall in six patients with breast cancer after modified radical mastectomy (MRM). We measured the in-vivo skin doses while both conventional and 3D-printed boluses were placed on the chest wall and compared the mean doses delivered to the ipsilateral lung and the heart. The homogeneity and conformity of the dose distribution in the chest wall for both types of boluses were also evaluated. The uniformity index on the chest skin was improved when the 3D-printed boluses were used, with the overall average skin dose being closer to the prescribed one in the former case (-0...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27779979/outcomes-of-nipple-sparing-mastectomy-role-of-anatomic-measurements
#19
Seyed S Pairawan, Derek Cody, Hahns Kim, M Katherine Hughes, Naveenraj Solomon, Maheswari Senthil, Carlos Garberoglio, Sharon Lum
Nipple-sparing mastectomy (NSM) offers improved cosmesis for women undergoing mastectomy; however, there is increased risk for complications with this technique. We sought to determine if standard anatomic measurements could be used to predict complications of NSM. We performed a retrospective review of NSM for which anthropometric measurements of sternal notch to nipple distance, base width, and inframammary fold to nipple distance were available, and compared outcomes by anatomic measurements. We identified 102 cases of NSM with measurements available for study performed in 55 patients...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27779705/diphenhydramine-induces-melanoma-cell-apoptosis-by-suppressing-stat3-mcl-1-survival-signaling-and-retards-b16-f10-melanoma-growth-in-vivo
#20
Chi-Hung R Or, Hong-Lin Su, Wee-Chyan Lee, Shu-Yi Yang, Cheesang Ho, Chia-Che Chang
Melanoma is the most aggressive skin malignancy with a high rate of mortality and is frequently refractory to many therapeutics, thus demanding the discovery of novel effective anti-melanoma agents. Diphenhydramine (DPH) is an H1 histamine receptor antagonist and a relatively safe drug. Previous studies have revealed the in vitro cytotoxicity of DPH against melanoma cells, but the mechanisms involved concerning its cytotoxicity and the in vivo anti-melanoma effect remain unknown. We herein present the first evidence supporting that DPH is selectively proapoptotic for a panel of melanoma cell lines irrespective of BRAFV600E status while sparing normal melanocytes...
October 25, 2016: Oncology Reports
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