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https://www.readbyqxmd.com/read/28816143/radiation-therapy-versus-no-radiation-therapy-to-the-neo-breast-following-skin-sparing-mastectomy-and-immediate-autologous-free-flap-reconstruction-for-breast-cancer-patient-reported-and-surgical-outcomes-at-1-year-a-mastectomy-reconstruction-outcomes-consortium
#1
MULTICENTER STUDY
Andrew L Cooke, Julian Diaz-Abele, Tom Hayakawa, Ed Buchel, Kimberly Dalke, Pascal Lambert
PURPOSE: To determine whether adjuvant radiation therapy (RT) is associated with adverse patient-reported outcomes and surgical complications 1 year after skin-sparing mastectomy and immediate autologous free flap reconstruction for breast cancer. METHODS AND MATERIALS: We compared 24 domains of patient-reported outcome measures 1 year after autologous reconstruction between patients who received adjuvant RT and those who did not. A total of 125 patients who underwent surgery between 2012 and 2015 at our institution were included from the Mastectomy Reconstruction Outcomes Consortium study database...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28807531/absent-cardiac-and-muscle-sympathetic-nerve-activities-involvement-in-ross-syndrome-a-follow-up-study
#2
E Fileccia, R Liguori, P Cortelli, V Donadio
PURPOSE: Ross syndrome (RS) is characterized by selective involvement of post-ganglionic skin sympathetic nerve fibres. We report a follow-up study in 4 patients to clarify whether in RS autonomic dysfunction spreads affecting also cardiovascular system. METHODS: The patients underwent cardiovascular reflexes (CVR) and microneurography recording of muscle sympathetic nerve activity (MSNA) for a follow-up mean period of 5years. RESULTS: CVR and MSNA were normal at baseline and unchanged over the follow-up...
August 9, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28789575/prescriptions-for-atopic-dermatitis-oral-corticosteroids-remain-commonplace
#3
Tiffany Alexander, Elena Maxim, Leah A Cardwell, Aneesh Chawla, Steven R Feldman
INTRODUCTION: Atopic dermatitis (AD) is a common, chronic inflammatory skin disease characterized by pruritic, often lichenified, patches and plaques. METHODS: Data were obtained from the Humana database, a large claims-based database encompassing more than 20 million patients under a commercial healthcare insurance plan. Our cohort included 39,526 subjects who saw a dermatologist for a primary ICD-9 diagnosis of atopic dermatitis (691.8) between the years of 2010-2015...
August 9, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28782140/dermoscopic-and-reflectance-confocal-microscopic-presentation-of-hailey-hailey-disease-a-case-series
#4
A Oliveira, E Arzberger, B Pimentel, V C de Sousa, P Leal-Filipe
BACKGROUND/PURPOSE: Hailey-Hailey disease is a rare inherited acantholytic skin disorder characterized by heterogeneous clinical presentation. Its differential diagnosis might be wide, including other genodermatoses, inflammatory, and infectious skin diseases. Although histopathology remains as diagnostic gold standard, noninvasive techniques such as dermoscopy and reflectance confocal microscopy may assist clinical examination. Herein, we aim to further characterize the dermoscopic and reflectance confocal microscopic presentation of Hailey-Hailey disease with histologic correlation...
August 7, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28780055/-amoxicillin-induced-skin-rash-sparing-a-plaque-of-erythema-migrans-renb%C3%A3-k-phenomenon-case-report-and-literature-review
#5
M Dumas, L Blum, E Begon
INTRODUCTION: Renbök phenomenon describes the inhibition of a lesion when a different one appears. We describe the first case of Renbök phenomenon occurring in a context of erythema migrans (EM) spared by an amoxicillin-induced skin rash and we also present a literature review. CASE REPORT: A 60-year-old patient was treated with amoxicillin for EM on the right knee and subsequently developed generalized erythema as a result of an antibiotic-induced skin rash, with sparing of the area previously affected by EM...
August 2, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28766233/prospective-study-comparing-surgeons-pain-and-fatigue-associated-with-nipple-sparing-versus-skin-sparing-mastectomy
#6
Rubie Sue Jackson, Thomas Sanders, Adrian Park, Robert Buras, Wen Liang, Christine Harris, Charles Mylander, Martin Rosman, Luther Holton, Devinder Singh, Laura Martino, Lorraine Tafra
BACKGROUND: Nipple-sparing mastectomy (NSM) is more technically challenging than skin-sparing mastectomy (SSM) but offers quality-of-life and cosmetic advantages. However, surgeon physical symptoms related to NSM workload have not been documented. METHODS: This was a prospective study using questionnaires to compare surgeon-reported physical symptoms before, during, and after NSM versus SSM. Surgeons also answered general questions about each mastectomy. Bilateral cases were performed simultaneously by two surgeons, who completed independent questionnaires...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28766219/a-10-year-experience-with-mastectomy-and-tissue-expander-placement-to-facilitate-subsequent-radiation-and-reconstruction
#7
Zeina Ayoub, Eric A Strom, Valentina Ovalle, George H Perkins, Wendy A Woodward, Welela Tereffe, Benjamin D Smith, Simona F Shaitelman, Michael C Stauder, Karen E Hoffman, Sarah M DeSnyder, Patrick B Garvey, Mark W Clemens, Carlos H Barcenas, Henry M Kuerer, Steven Kronowitz
BACKGROUND: An integrated approach to skin sparing mastectomy with tissue expander placement followed by radiotherapy and delayed reconstruction was initiated in our institution in 2002. The purpose of this study was to assess the surgical outcomes of this strategy. METHODS: Between September 2002 and August 2013, a total of 384 reconstructions had a tissue expander placed at the time of mastectomy and subsequently underwent radiotherapy. Rates and causes of tissue expander explantation before, during, and after radiotherapy, as well as tumor specific outcomes and reconstruction approaches, were collected...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28758229/time-dependent-factors-in-diep-flap-breast-reconstruction
#8
Rosaria Laporta, Benedetto Longo, Michail Sorotos, Alessio Farcomeni, Vittoria Amorosi, Fabio Santanelli di Pompeo
BACKGROUND: The process of harvesting and performing microsurgical anastomosis may lengthen deep inferior epigastric artery perforator (DIEP) flap breast reconstruction affecting results and patient safety. The aim of the study was to investigate the associations between predictors and operative time (OT). METHODS: Between 2004 and 2016, 336 immediate and 68 delayed unilateral reconstructions were performed in 404 patients. Age, weight, height, body mass index (BMI), nulliparity, or pluriparity condition were collected to determine the impact of patient characteristics on OT...
July 24, 2017: Microsurgery
https://www.readbyqxmd.com/read/28749618/radiation-induced-second-cancer-risk-from-external-beam-photon-radiotherapy-for-head-and-neck-cancer-impact-on-in-field-and-out-of-field-organs
#9
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy
The purpose of this paper is to provide data on development of second primary cancers within or adjacent to tissue irradiated in the treatment of primary head and neck cancers using different techniques and modalities. Materials and methods: We selected five patients with HandN tumors located in base of the tongue for risk assessment. In order to examine the impact of choices of various planning techniques, numbers of beams and beam energy used in treatment plans - 7 and 9 field Intensity modulated radiotherapy (IMRT) plans using 6MV and 10 MV beam energies and a 6MV Volumetric modulated arc therapy (VMAT) plans were planned...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28742054/laue-lens-for-radiotherapy-applications-through-a-focused-hard-x-ray-beam-a-feasibility-study-on-requirements-and-tolerances
#10
Riccardo Camattari
Focusing a hard x-ray beam would represent an innovative technique for tumour treatment, since such a beam may deliver a dose to a tumour located at a given depth under the skin, sparing the surrounding healthy cells. A detailed study of a focusing system for hard x-ray aimed at radiotherapy is presented here. Such a focusing system, named Laue lens, exploits x-ray diffraction and consists of a series of crystals disposed as concentric rings capable of concentrating a flux of x-rays towards a focusing point...
August 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28740781/direct-to-implant-reconstruction-in-nipple-sparing-mastectomy-patient-selection-by-preoperative-digital-mammogram
#11
Alberto O Rancati, Claudio H Angrigiani, Dennis C Hammond, Maurizio B Nava, Eduardo G Gonzalez, Julio C Dorr, Gustavo F Gercovich, Nicola Rocco, Roman L Rostagno
BACKGROUND: Digital mammography clearly distinguishes gland tissue density from the overlying nonglandular breast tissue coverage, which corresponds to the existing tissue between the skin and the superficial layer of the fascia superficialis surrounding the gland (i.e., dermis and subcutaneous fat). Preoperative digital imaging can determine the thickness of this breast tissue coverage, thus facilitating planning and reducing the rate of necrotic complications after direct to implant (DTI) reconstruction in nipple sparing mastectomy (NSM)...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28738698/implementation-and-evaluation-of-a-rehabilitation-concept-in-a-patient-suffering-from-scleredema-adultorum-buschke-a-case-report
#12
Michael Mickel, Ahmad Jalili, Christina Gesslbauer, Richard Crevenna
PURPOSE: Scleredema Adultorum Buschke is a disorder manifesting indurations of the skin mostly followed by musculoskeletal impairment. Data regarding this fact are seldom found and documentation of functional outcome of physical therapies and modalities related to Scleredema Adultorum Buschke is fragmentary. The aim of this case report is to demonstrate and to document an effective concept of rehabilitation in a patient suffering from Scleredema Adultorum Buschke. METHODS: A treatment plan was developed containing therapeutic ultrasound, manual lymphatic drainage, and physiotherapy...
July 24, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28728333/the-lazy-s-design-a-novel-skin-closure-design-in-skin-sparing-mastectomy-for-implant-based-breast-reconstruction
#13
June-Kyu Kim, Yong Seong Kim
Preservation of the breast skin envelope during immediate implant-based breast reconstruction is important for producing symmetrical and natural-looking breasts. We propose the lazy S design for the closure of round-shaped wounds with the hope of improving the aesthetic outcomes and reducing the tension on the wound by preserving the skin. Additionally, the direction of tension is dispersed due to the shape of this design. Patients undergoing implant reconstruction after skin-sparing mastectomy may benefit from the lazy S design...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28720989/trapezius-perforator-flap-for-reconstruction-of-a-posterior-cervical-defect
#14
Ricardo Nascimento, Joana Costa, Ricardo Horta, Álvaro Silva
The use of free flaps is considered the "gold standard" for reconstruction of head and neck defects. Locoregional flaps allows a better aesthetic result compared to free flaps, whenever there's an external skin defect. However the use of free flaps is not always adequate in the presence of preoperative comorbidities or previous surgeries. Since the description of the trapezius myocutaneous flap in the 1980's, many authors have published the results of the applicability of this flap in head and neck salvage reconstructive surgery...
April 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28720851/microneedle-patch-delivery-of-influenza-vaccine-during-pregnancy-enhances-maternal-immune-responses-promoting-survival-and-long-lasting-passive-immunity-to-offspring
#15
E Stein Esser, Joanna A Pulit-Penaloza, Haripriya Kalluri, Devin McAllister, Elena V Vassilieva, Elizabeth Q Littauer, Nadia Lelutiu, Mark R Prausnitz, Richard W Compans, Ioanna Skountzou
Influenza virus causes life-threatening infections in pregnant women and their newborns. Immunization during pregnancy is the most effective means of preventing maternal and infant mortality/morbidity; however, influenza vaccination rates of pregnant women remain under 50%. Furthermore, the availability of vaccines in low-resource populations is limited. Skin immunization with microneedle patches (MN) is a novel and safe vaccination platform featuring thermostable vaccine formulations. Cold-chain independence and the potential for self-administration can expand influenza vaccination coverage in developing countries...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716116/catching-and-monitoring-clinical-innovation-through-performance-indicators-the-case-of-the-breast-conserving-surgery-indicator
#16
Anna Maria Murante, Silvio Candelori, Paola Rucci, Sabina Nuti, Manuela Roncella, Matteo Ghilli, Andrea Mercatelli, Maria Pia Fantini
BACKGROUND: The evolution in the surgical and diagnostic procedures, the attention to women's preferences, the case mix, and differences in professional practices may lead to a variability in the quality of breast cancer clinical pathway. To catch and manage this variability it is important to use valid measures. The aim of this paper is to examine the concurrent validity of the breast-conserving surgery (BCS) indicator and to provide evidence to guide the quality improvement process...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28709454/comparison-of-skin-sparing-mastectomy-using-ligasure%C3%A2-small-jaw-and-electrocautery
#17
Young Woo Chang, Hwan Soo Kim, Seung Pil Jung, Sang Uk Woo, Jae Bok Lee, Jeoung Won Bae, Gil Soo Son
BACKGROUND: Skin-sparing mastectomy (SSM) is increasingly used in patients with breast cancer. We compared the differences between use of electrocautery and LigaSure™ Small Jaw in patients with breast cancer who underwent SSM. METHODS: Between January 2012 and December 2015, 81 patients with breast cancer who underwent SSM were selected and were divided into the electrocautery group and the LigaSure™ Small Jaw group based on the devices that were used. Clinicopathological characteristics, body mass index, operative time, and weight of removed breast were obtained from medical records...
July 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28705456/feeling-touch-on-the-own-hand-restores-the-capacity-to-visually-discriminate-it-from-someone-else-hand-pathological-embodiment-receding-in-brain-damage-patients
#18
Carlotta Fossataro, Valentina Bruno, Patrizia Gindri, Lorenzo Pia, Anna Berti, Francesca Garbarini
The sense of body ownership, i.e., the belief that a specific body part belongs to us, can be selectively impaired in brain-damaged patients. Recently, a pathological form of embodiment has been described in patients who, when the examiner's hand is located in a body-congruent position, systematically claim that it is their own hand (E+ patients). This paradoxical behavior suggests that, in these patients, the altered sense of body ownership also affects their capacity of visually discriminating the body-identity details of the own and the alien hand, even when both hands are clearly visible on the table...
June 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28699269/determinants-of-short-and-long-term-outcomes-in-patients-undergoing-immediate-breast-reconstruction-following-neoadjuvant-chemotherapy
#19
Craig A Wengler, Stephanie A Valente, Zahraa AlHilli, Neil M Woody, Julia H Muntean, Jame Abraham, Rahul D Tendulkar, Risal Djohan, Colin O'Rourke, Joseph P Crowe, Stephen R Grobmyer
BACKGROUND: We evaluated oncologic outcomes and complications of skin-sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) with immediate reconstruction (IR) after neoadjuvant chemotherapy (NAC) in patients with early-stage and locally advanced breast cancer (BC). METHODS: BC patients from 2000 to 2014 treated with NAC followed by SSM/NSM and IR were reviewed. Patient demographics, tumor characteristics, NAC response, complications, and recurrence were analyzed...
July 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28697225/low-dose-methotrexate-for-vitiligo
#20
Anna Cristina Garza-Mayers, Daniela Kroshinsky
<p>BACKGROUND: Treatment of vitiligo is aimed at repigmentation and often consists of multiple modalities, none of which are universally or rapidly successful. Extensive cases are most often treated with ultraviolet light therapy, which can be both costly and time-consuming. Though vitiligo is an autoimmune disease, there is no current data to support systemic immunosuppressive monotherapy.</p> <p>CASE SUMMARY: Here we present a case series of 3 patients with vitiligo treated for 11-16 months with low-dose methotrexate (12...
July 1, 2017: Journal of Drugs in Dermatology: JDD
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