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https://www.readbyqxmd.com/read/29033382/clinical-pathological-correlations-in-three-patients-with-fibrodysplasia-ossificans-progressiva
#1
Kelly L Wentworth, Katherine Bigay, Tea V Chan, Jennifer P Ho, Blanca M Morales, Joseph Connor, Erin Brooks, M Shahriar Salamat, Henry Charles Sanchez, Geoffrey Wool, Robert J Pignolo, Frederick S Kaplan, Edward C Hsiao
OBJECTIVE: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder in which heterotopic bone forms in the soft tissues. This often occurs in response to injury or inflammation, leading to joint immobilization and significant disability. There are currently no definitive treatment options for this devastating disease. Although the most dramatic phenotype in FOP is the episodic and progressive heterotopic ossification, patients report a number of symptoms that affect other organ systems...
October 12, 2017: Bone
https://www.readbyqxmd.com/read/29032865/electron-postmastectomy-chest-wall-plus-comprehensive-nodal-irradiation-technique-using-electron-monte-carlo-dose-algorithm
#2
Linda Hong, Ase Ballangrud, Beryl McCormick, James Mechalakos
For left-sided postmastectomy patients requiring chest wall plus comprehensive nodal irradiation, sometimes traditional techniques such as partial wide tangents or electron/tangents combination are not feasible due to abnormal chest wall contour or heart position or unusually wide excision scar. We developed electron chest wall irradiation technique using Electron Monte Carlo (EMC) dose algorithm that will achieve heart sparing with acceptable ipsilateral lung dose, minimal contralateral lung, and breast dose...
October 9, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29032119/a-systematic-review-of-safety-and-efficacy-of-systemic-corticosteroids-in-atopic-dermatitis
#3
Sherry Yu, Aaron M Drucker, Mark Lebwohl, Jonathan I Silverberg
BACKGROUND: Systemic corticosteroids are often used to treat atopic dermatitis (AD). However, few studies assessed the safety and efficacy of systemic corticosteroids in AD. OBJECTIVE: To systematically review the literature on efficacy and safety of systemic corticosteroid use (oral, intramuscular, intravenous) in AD. METHODS: PubMed, Embase, Medline, Scopus, Web of Science, and Cochrane Library were searched. We included systematic reviews, guidelines and treatment reviews of systemic corticosteroid use among patients of all ages with a diagnosis of AD (52 reviews and 12 studies)...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29030030/oncological-safety-of-nipple-sparing-prophylactic-mastectomy-a-review-of-the-literature-on-3716-cases
#4
T Muller, A Baratte, C Bruant-Rodier, F Bodin, C Mathelin
INTRODUCTION: The objective of our study was to evaluate the risk of cancer after prophylactic nipple-sparing mastectomy (PNSM). MATERIAL AND METHODS: The PubMed database was consulted using the following key-words: "nipple-sparing mastectomy", "prophylactic", "locoregional recurrence", "oncological risk". Articles published between January 1995 and December 2016 were searched. RESULTS: Out of the 270 articles found, 19 were included. Overall, 15 studies were retrospective, 2 prospective, 2 prospective and retrospective and 3 were multicentric...
October 10, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28990681/limb-shortening-as-a-strategy-for-limb-sparing-treatment-of-appendicular-osteosarcoma-of-the-distal-radius-in-a-dog
#5
Sarah E Boston, Owen T Skinner
OBJECTIVE: To develop and report a novel limb sparing technique for the distal radius in a dog. STUDY DESIGN: Case report. ANIMAL: A 14-year-old, female spayed Labrador Retriever with an osteosarcoma of the right distal radius and a pathological fracture. A previous mast cell tumor had been treated 5 years prior to presentation with marginal excision and a full-course radiation over the right metacarpal bones. The dog had received 2 doses of palliative radiation just prior to presentation...
October 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28987747/treating-locally-advanced-lung-cancer-with-a-1-5t-mr-linac-effects-of-the-magnetic-field-and-irradiation-geometry-on-conventionally-fractionated-and-isotoxic-dose-escalated-radiotherapy
#6
Hannah E Bainbridge, Martin J Menten, Martin F Fast, Simeon Nill, Uwe Oelfke, Fiona McDonald
PURPOSE: This study investigates the feasibility and potential benefits of radiotherapy with a 1.5T MR-Linac for locally advanced non-small cell lung cancer (LA NSCLC) patients. MATERIAL AND METHODS: Ten patients with LA NSCLC were retrospectively re-planned six times: three treatment plans were created according to a protocol for conventionally fractionated radiotherapy and three treatment plans following guidelines for isotoxic target dose escalation. In each case, two plans were designed for the MR-Linac, either with standard (∼7mm) or reduced (∼3mm) planning target volume (PTV) margins, while one conventional linac plan was created with standard margins...
October 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28986987/monte-carlo-simulations-of-a-kilovoltage-external-beam-radiotherapy-system-on-phantoms-and-breast-patients
#7
Dylan Y Breitkreutz, Michael D Weil, Sergei Zavgorodni, Magdalena Bazalova-Carter
PURPOSE: To determine the most suitable lesion size and depth for radiotherapy treatments with a prototype kilovoltage x-ray arc therapy (KVAT) system through Monte Carlo simulations of the dose delivered to lesion, dose homogeneity and lesion-to-skin ratio. METHODS: Monte Carlo simulations were used to calculate dose distributions generated by a novel low-energy kilovoltage x-ray system to a variety of clinically relevant lesion sizes and depths in phantoms and for hypothetical partial breast irradiations of patients in supine and prone positions...
October 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28978798/selective-blockade-of-cd28-on-human-t-cells-facilitates-regulation-of-alloimmune-responses
#8
Masaaki Zaitsu, Fadi Issa, Joanna Hester, Bernard Vanhove, Kathryn J Wood
T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation. CTLA4-Ig molecules that bind CD80/86 and inhibit CD28 costimulation offer an alternative immunosuppressive treatment, free from some of the chronic toxicities associated with calcineurin inhibition. However, CD80/86 blockade by CTLA4-Ig also results in the loss of coinhibitory CTLA4 signals that are critical to the regulation of T cell activation...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28975840/in-the-age-of-breast-augmentation-breast-reconstruction-provides-an-opportunity-to-augment-the-breast
#9
Amanda L Zimmerman, Bugra Tugertimur, Paul D Smith, Ambuj Kumar, Deniz Dayicioglu
BACKGROUND: Augmentation mammoplasty remains the most common cosmetic surgery procedure performed. The objective of this article is to evaluate the impact of augmented volume of the reconstructed breast in patients that undergo nipple-sparing mastectomy and patients previously augmented who undergo mastectomy with tissue expander/implant-based reconstruction. METHODS: Patients undergoing skin-sparing mastectomy, nipple-sparing mastectomy, and mastectomy after previous augmentation followed by tissue expander/implant-based reconstruction between June 2011 and April 2015 by 2 surgeons at the same institution were included...
October 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28975239/association-of-autologous-costal-cartilage-harvesting-technique-with-donor-site-pain-in-patients-undergoing-rhinoplasty
#10
Berke Özücer, Mehmet Emre Dinç, Ceki Paltura, Ilker Koçak, Denizhan Dizdar, Oguz Çörtük, Ömer Uysal
Importance: Postoperative pain at the donor site is a common morbidity following autologous costal cartilage grafting. Objective: To evaluate postoperative pain at the donor site after the use of a muscle-sparing costal cartilage harvesting technique compared with a muscle-cutting technique using electrocautery. Design, Setting, and Participants: Designed as a controlled trial without randomization, this prospective, comparative cohort study was conducted between January 1, 2016, and March 31, 2017...
September 21, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28975182/radionuclides-in-oncology-clinical-practice-review-of-the-literature
#11
Helena Luna Pais, Irina Alho, Inês Vendrell, André Mansinho, Luís Costa
Radionuclide therapy is a type of targeted therapy that can be useful in the treatment of several malignant tumors. Compared with other forms of systemic therapy used in cancer - including chemotherapy - it has the advantage of sparing biological structures adjacent to the tumor cells. This treatment modality has registered significant advances since its first use for the treatment of tuberculous skin lesions in the 1900s. This paper reviews the characteristics and clinical applications of therapeutic radionuclides commonly used in the oncology clinical practice, and discusses future potential applications...
October 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28974873/the-modified-posterior-thoracotomy-for-esophageal-atresia
#12
Mohamed Oulad Saiad
AIMS: Right dorsolateral thoracotomy with splitting or sparing the latissimus dorsi is the standard approach to the esophageal atresia. The thoracoscopic approach to the treatment of esophageal atresia is a demanding procedure used only by few surgeons in few centers. The purpose of this study is to present the modified posterior thoracotomy for neonates with esophageal atresia. PATIENTS AND METHODS: Between January 2007 and May 2016, the modified posterior thoracotomy was performed in 56 neonates with esophageal atresia...
October 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28973707/expanding-eligibility-criteria-for-nipple-sparing-mastectomy
#13
Sonia T Orcutt, Cristina O'Donoghue, Paul Smith, Christine Laronga
The use of mastectomy has increased in patients who are high-risk genetic carriers who need or desire mastectomy for prophylactic reasons, as well as for patients who have breast cancer and need or desire mastectomy for treatment of their cancer. Retaining the nipple and skin with a nipple-sparing mastectomy results in improved patient satisfaction as compared with traditional mastectomy, without compromise of oncologic principles. This technique has been performed in patients with small, peripherally located tumors and nonptotic breasts; in recent years, however, consideration has been given to patients with more centrally located, larger tumors, and patients undergoing radiation or with ptotic breasts with the potential for poor cosmetic outcome...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28971471/dermatoscopic-evaluation-and-histopathological-correlation-of-acquired-dermal-macular-hyperpigmentation
#14
Keshavamurthy Vinay, Anuradha Bishnoi, Davinder Parsad, Uma N Saikia, Muthu Sendhil Kumaran
BACKGROUND: Acquired dermal macular hyperpigmentation (ADMH) is a hypernym encompassing Riehl's melanosis, lichen planus pigmentosus, and ashy dermatoses that show significant clinicopathological overlap. We sought to describe the dermatoscopic features of ADMH and correlate them with histopathological findings. METHODS: This was a prospective observational study performed in two phases. A detailed clinical and dermatoscopic examination was performed, and skin biopsies were obtained in 51 patients...
October 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28967564/multidisciplinary-international-survey-of-post-operative-radiation-therapy-practices-after-nipple-sparing-or-skin-sparing-mastectomy
#15
Gustavo Nader Marta, Philip Poortmans, Alfredo C de Barros, José Roberto Filassi, Ruffo Freitas Junior, Riccardo A Audisio, Max Senna Mano, Sarkis Meterissian, Sarah M DeSnyder, Thomas A Buchholz, Tarek Hijal
PURPOSE/OBJECTIVE(S): Skin sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) have entered routine surgical practice for breast cancer, though their oncologic safety has not been established in randomized controlled trials. The aim of this study was to evaluate and compare radiation oncologists' and breast surgeons' opinions concerning the indications of post-operative radiation therapy (PORT) after SSM and NSM. MATERIALS/METHODS: Radiation oncologists and breast surgeons from North America, South America and Europe were invited to contribute in this study...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28964902/skin-vaccination-using-microneedles-coated-with-a-plasmid-dna-cocktail-encoding-nucleosomal-histones-of-leishmania-spp
#16
Esther Moreno, Juana Schwartz, Alba Calvo, Laura Blanco, Esther Larrea, Juan M Irache, Carmen Sanmartín, Sion A Coulman, Manuel Soto, James C Birchall, Socorro Espuelas
Vaccine delivery using microneedles (MNs) represents a safe, easily disposable and painless alternative to traditional needle immunizations. The MN delivery of DNA vaccines to the dermis may result in a superior immune response and/or an equivalent immune response at a lower vaccine dose (dose-sparing). This could be of special interest for immunization programs against neglected tropical diseases such as leishmaniasis. In this work, we loaded a MN device with 60μg of a plasmid DNA cocktail encoding the Leishmania infantum nucleosomal histones H2A, H2B, H3 and H4 and compared its immunogenicity and protective capacity against conventional s...
September 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28964620/-fasciocutaneous-flap-reliable-by-deep-femoral-artery-perforator-for-the-treatment-of-ischial-pressure-ulcers
#17
L Gebert, F Boucher, A Lari, F Braye, A Mojallal, M Ismaïl
INTRODUCTION: The surgical management of pressure ulcers in the paraplegic or quadriplegic population is marked by the high risk of recurrence in the long-term. In the current era of perforator flaps, newer reconstructive options are available for the management of pressure ulcers, decreasing the need to use the classically described muscular or musculocutaneous locoregional flaps. The coverage of ischial sores described in this article by a pedicled flap based on a deep femoral artery perforator, appears to be an effective first-line reconstructive option for the management of limited size pressure ulcers...
September 27, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28958980/favorable-outcome-with-close-margins-in-patients-undergoing-nipple-skin-sparing-mastectomy-with-immediate-breast-reconstruction-5-year-follow-up
#18
Enver Özkurt, Mustafa Tükenmez, Erdem Güven, Burcu Çelet Özden, Gizem Öner, Mahmut Müslümanoğlu, Abdullah İğci, Vahit Özmen, Seden Küçücük, Neslihan Cabioğlu
BACKGROUND: Implant-based breast reconstruction after mastectomy has recently been reported to be the preferred type of surgery among breast specific surgeons and plastic surgeons. AIMS: The aim of this study is to explore the significant clinicopathological factors associated with long term outcome related to local recurrences of the nipple among patients who underwent immediate breast reconstruction (IBR) with tissue expander (TE) or implant after mastectomy. STUDY DESIGN: Retrospective cohort Methods: From January 2007 to January 2013, 51 breast cancer patients who underwent IBR with TE or implant were retrospectively analyzed...
September 29, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28947293/an-ecological-study-of-skin-biopsies-and-skin-cancer-treatment-procedures-in-the-united-states-medicare-population-2000-to-2015
#19
David M Wang, Frederick C Morgan, Robert J Besaw, Chrysalyne D Schmults
BACKGROUND: Analyses of skin cancer procedures adjusted for population changes are needed. OBJECTIVE: To describe trends in skin cancer-related biopsies and procedures in Medicare beneficiaries. METHODS: An ecological study of Medicare claims for skin biopsies and skin cancer procedures, 2000-2015. RESULTS: Biopsies increased 142%, and skin cancer procedures increased 56%. Mohs micrographic surgery (MMS) utilization increased on head/neck, hands/feet, and genitalia (11% to 27% of all treatment procedures) but was low on trunk/extremities (1% to 4%)...
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28942361/extracellular-and-non-chaperone-function-of-heat-shock-protein-90alpha-hsp90%C3%AE-is-required-for-skin-wound-healing
#20
Ayesha Bhatia, Kathryn O'Brien, Jiacong Guo, Vadim Lincoln, Chiaki Kajiwara, Mei Chen, David T Woodley, Heiichiro Udono, Wei Li
Despite years of effort and investment, there are few topical or systemic medications for skin wounds. Identifying natural "drivers" of wound healing could facilitate the development of new and effective treatments. When skin is injured, there is a massive increase of heat shock protein 90alpha (Hsp90α) protein inside the wound bed. The precise role for these Hsp90α proteins, however, was unclear. The availability of a unique mouse model that lacked the intracellular ATPase-driven chaperoning, but spared the extracellular F-5-supported pro-motility, function of Hsp90α allowed us to test specifically the role of the non-chaperone function of Hsp90α in normal wound closure...
September 20, 2017: Journal of Investigative Dermatology
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