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https://www.readbyqxmd.com/read/28103903/intraoperative-radiotherapy-iort-as-boost-in-breast-cancer
#1
REVIEW
Felix Sedlmayer, Roland Reitsamer, Frederik Wenz, Elena Sperk, Christoph Fussl, Julia Kaiser, Ingrid Ziegler, Franz Zehentmayr, Heinz Deutschmann, Peter Kopp, Gerd Fastner
The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors...
January 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28095544/a-split-face-assessment-of-the-synergistic-potential-of-sequential-q-switched-nd-yag-laser-and-1565-nm-fractional-nonablative-laser-treatment-for-facial-rejuvenation-in-fitzpatrick-skin-type-ii-v-patients
#2
Girish Munavalli
Recent appreciation of the multifactorial pathophysiology of skin aging has led to increased use of parallel treatment regimens. This prospective, split-face, randomized study assessed the safety and efficacy of same-day sequential Q-switched Nd:YAG laser and 1565 nm non-ablative fractional laser (SST) facial rejuvenation treatment in comparison to fractional non-ablative laser (NAFL) treatment only. Seventeen patients underwent three treatment sessions, conducted at 4-6-week intervals, in which SST treatment was delivered on a randomly selected side of the face followed by NAFL treatment on the contralateral side immediately thereafter...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095532/1060-nm-diode-hyperthermic-laser-lipolysis-the-latest-in-non-invasive-body-contouring
#3
Laura Schilling, Nazanin Saedi, Robert Weiss
Non-invasive body contouring is becoming increasingly popular in the United States. Using the 1060 nm diode laser to achieve hyperthermic temperatures within the adipose tissue with subsequent lipolysis is one of the most recent advancements in this field and is the first of its kind. This wavelength was carefully chosen to effectively target the unwanted adipocytes while sparing the overlying skin and adnexae. Appreciable results are achieved after a single treatment, and these results are comparable to other non-invasive technologies...
January 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28087389/evaluation-of-local-oncologic-safety-in-nipple-areola-complex-sparing-mastectomy-after-primary-chemotherapy-a-propensity-score-matched-study
#4
Roberto Agresti, Marco Sandri, Massimiliano Gennaro, Giulia Bianchi, Ilaria Maugeri, Mario Rampa, Giuseppe Capri, Maria Luisa Carcangiu, Giovanna Trecate, Egidio Riggio, Laura Lozza, Filippo de Braud
BACKGROUND: Nipple-areola complex-sparing mastectomy (NSM), extending the concept of skin-sparing mastectomy, allows for the provision of a better cosmetic result. Large operable T2-T3 breast cancer might theoretically appear suitable for this surgical option as an alternative to conventional mastectomy or breast-conserving surgery, when a good response to primary chemotherapy has been achieved. PATIENTS AND METHODS: From January 2009 to May 2013, 422 patients with invasive breast cancer were progressively accrued to NSM...
December 24, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28065399/oncologic-safety-of-immediate-breast-reconstruction-in-breast-cancer-patients-who-underwent-neoadjuvant-chemotherapy-short-term-outcomes-of-a-matched-case-control-study
#5
Jai Min Ryu, Sungmin Park, Hyun-June Paik, Seok Jin Nam, Seok Won Kim, Se Kyung Lee, Jonghan Yu, Soo Youn Bae, Isaac Kim, Sa Ik Bang, Goo-Hyun Mun, Jai-Kyong Pyon, Byung-Joon Jeon, Jeong Eon Lee
INTRODUCTION: Although the indication for immediate breast reconstruction (IBR) after skin-sparing mastectomy (SSM) or nipple-sparing mastectomy (NSM) has been expanded, IBR after neoadjuvant chemotherapy (NACT) is still controversial. We conducted retrospective matched case-control study to analyze oncologic outcomes between patients who underwent TM only and those who underwent IBR after SSM or NSM after NACT. PATIENTS AND METHODS: A retrospective review of breast cancer patients who underwent IBR after SSM or NSM after NACT between 2008 and 2015 at a single center was conducted...
October 27, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28058777/platysma-sparing-vascularized-submental-lymph-node-flap-transfer-for-extremity-lymphedema
#6
Igor Poccia, Chia-Yu Lin, Ming-Huei Cheng
BACKGROUND AND OBJECTIVES: Due to its consistent vascular and lymphatic anatomy, the vascularized submental lymph node flap is a reliable option for lymphedema treatment. Despite these advantages, flap harvest requires resection of platysma, which may cause a marginal mandibular nerve pseudo-paralysis. The aim of this study was to investigate the donor site morbidity of an innovative platysma-sparing vascularized submental lymph node flap transfer for treating extremity lymphedema. METHODS: Ten patients undergoing platysma sparing submental lymph-node flap harvest were prospectively enrolled in the study and compared with a control group of 10 patients who underwent standard submental lymph-node flap harvest...
January 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28051266/one-stage-breast-reconstruction-techniques-in-elderly-patients-to-preserve-quality-of-life
#7
M Maruccia, M Mazzocchi, L A Dessy, M G Onesti
OBJECTIVE: The aim of this study was to review one-stage breast reconstruction techniques performed in elderly patients at our institution to identify the criteria of selection of each in terms of outcomes and quality of life. PATIENTS AND METHODS: Patients older than 65 years who underwent one-stage breast reconstruction between January 2004 and July 2014 at our hospital were included. Patients and procedure-related data were collected from the medical records...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28048327/su-f-p-58-squamous-cell-and-basal-cell-carcinoma-of-the-skin-treated-with-a-freiburg-flap-applicator
#8
K Dou, B Li, M Jacobs, B Laser
PURPOSE: To treat squamous cell and basal cell carcinoma of the skin with the Freiburg flap applicator using a high dose rate modality of an Elekta Flexitron or MicroSelectron for radiation delivery by compensating the dose deviation resulting from the incomplete scatter environment. METHODS: Patients were selected to have lesions greater than or equal to 2cm. A mask might be needed depending on special locations. The lesions on the eyelid and face presented in this research were, however, treated without a mask...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048315/su-f-t-650-the-comparison-of-robotic-partial-breast-stereotactic-irradiation-using-mlc-vs-iris-cone
#9
C Ding, R Timmerman, S Jiang, A Rahimi
PURPOSE: To evaluate the dosimetric impact on treatment planning for partial breast stereotactic irradiation using Cyberknife with MLC versus Iris Cone. METHODS: Ten patients whom underwent lumpectomy for DCIS or stage I invasive non-lobular epithelial breast cancer were included in this study. All patients were previously treated on the Cyberknife using Iris cone with the prescription dose of 37.5Gy in 5 fractions covering at least 95% of PTV on our phase I SBRT 5 fraction partial breast irradiation trial...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048201/su-f-t-646-sbrt-lung-moving-beyond-the-3d-conformal-paradigm-with-an-elekta-versahd-accelerator
#10
A Dalhart, D Hyer, B Allen, R Flynn, H Johnston
PURPOSE: To develop a volumetric modulated arc therapy (VMAT) planning and delivery methodology for lung stereotactic body radiation therapy (SBRT) that addresses the unique geometric challenges presented when using an Elekta VersaHD linear accelerator. METHODS: The Elekta VersaHD imaging panels are fixed at 160cm SID when deployed, limiting the ability to perform non-coplanar treatments due to collisions with the treatment table. The panels can be folded in a stored position for non-coplanar treatments, but in this configuration, longitudinal table travel is restricted by the space required for the folded panels...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047948/su-f-t-203-high-dose-definitive-proton-therapy-with-integrated-boost-to-hypoxic-subvolumes-determined-by-18f-fluoromisonidazole-fmiso-pet-ct-for-patients-with-recurrent-chordomas-using-intensity-modulated-proton-therapy-impt
#11
S Yan, G Broussard, K De, Amorim Bernstein, Y Wang
PURPOSE: Recurrent chordomas are difficult to control locally. This dosimetric study investigates the feasibility of dose escalation to hypoxic regions, visualized on FMISO-PET, while respecting the dose constraints to the neighboring normal tissues/organs. We propose to deliver a higher dose to the areas of hypoxia (84.5Gy) using IMPT with the goal of improving local control. METHODS: We currently have four patients with hypoxic subvolumes (HSV) greater than 10cc from the FMISO-PET image...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047599/su-f-t-515-increased-skin-dose-in-supine-craniospinal-irradiation-due-to-carbon-fiber-couch-and-vacuum-bag-immobilization-device
#12
D Robertson, Z Zhao, X Wang, J Yang
PURPOSE: To measure the surface dose for supine craniospinal irradiation employing posterior beams, treating through an imaging couch and BlueBag immobilization device. METHODS: The percentage depth dose (PDD) in the buildup region of a clinical 6 MV photon beam was measured using an Advanced Markus parallel plate ionization chamber in a solid water phantom. The PDD from a 10×10 cm(2) anterior beam was measured at 100 cm SSD, simulating a traditional prone craniospinal technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046723/su-f-t-27-a-comparative-case-study-among-four-modalities-for-the-superficial-treatment-of-squamous-cell-carcinoma
#13
M Ashenafi, N Koch, J Peng, L Terwillinger, J Wilder, D McDonald, C Mart, J Jenrette, K Vanek
PURPOSE: We performed a comparative planning study among High Dose Rate (HDR) brachytherapy, superficial electrons, Volume Modulated Arc Therapy (VMAT), and Helical IMRT (Tomotherapy) for squamous cell carcinoma of the abdominal wall with consideration for the underlining bowel. METHODS: A 69-year old female presented with squamous cell carcinoma protruding 8mm beyond the anterior skin surface of the midabdomen was considered for treatment. The patient had a ventral hernia which resulted in the reduction of the abdominal wall thickness and the adjacent small bowel being the dose limiting structure...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046639/su-f-t-85-energy-modulated-electron-postmastectomy-unreconstructed-pu-chest-wall-cw-irradiation-technique-to-achieve-heart-sparing
#14
L Hong, A Ballangrud, B McCormick, J Mechalakos
PURPOSE: For left-sided PU patients requiring CW and nodal irradiation, sometimes partial wide tangents (PWT) are not feasible due to abnormal chest wall contour or heart position close to the anterior chest wall or unusual wide excision scar. We developed an energy modulated electron chest wall irradiation technique that will achieve heart sparing. METHODS: Ten left-sided PU patients were selected for this dosimetry study. If PWT were used, the amount of the ipsilateral lung would be ranged 3...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046470/su-f-t-509-investigation-into-the-impact-of-the-linear-accelerator-treatment-table-on-skin-dose-to-prone-breast-patients
#15
K Pedersen, J Irwin, P Sansourekidou, S Kriminski, D Pavord
PURPOSE: To investigate the impact of the treatment table on skin dose for prone breast patients for which the breast contacts the table and to develop a method to decrease skin dose. METHODS: We used 12cm stack of 15cmx15cm solid water slabs to imitate breast. Calibrated EBT3 radiochromic film was affixed to the bottom of the phantom. Treatments for 32 patients were analyzed to determine typical prone breast beam parameters. Based on the analysis, a field size and a range of gantry angles were chosen for the test beams...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046453/su-g-tep3-09-proton-minibeam-radiation-therapy-increases-normal-tissue-resistance
#16
Y Prezado, W Gonzalez-Infantes, S Heinrich, D Labiod, M Juchaux, I Martinez-Rovira, C Nauraye, A Patriarca, C Peucelle, C Sebrie
PURPOSE: The dose tolerances of normal tissues continue being the main limitation in radiotherapy. To overcome it, we recently proposed a novel concept: proton minibeam radiation therapy (pMBRT) [1]. It allies the physical advantages of protons with the normal tissue preservation observed when irradiated with submillimetric spatially fractionated beams (minibeam radiation therapy) [2]. The dose distributions are such that the tumor receives a homogeneous dose distribution, while normal tissues benefit from the spatial fractionation of the dose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045880/targeted-complement-inhibition-protects-vascularized-composite-allografts-from-acute-graft-injury-and-prolongs-graft-survival-when-combined-with-subtherapeutic-cyclosporine-a-therapy
#17
Peng Zhu, Stefanie R Bailey, Biao Lei, Chrystal M Paulos, Carl Atkinson, Stephen Tomlinson
BACKGROUND: Recipients of vascularized composite allografts require aggressive and life-long immunosuppression, and since the surgery is usually performed in nonlife threatening situations, the development of strategies to minimize immunosuppression is especially pertinent for this procedure. We investigated how complement affects acute graft injury, alloimmunity, and immunosuppressive therapy. METHODS: Vascularized composite allografts were transplanted from Balb/C to C57BL/6 mice that were complement deficient (C3 or double C3a Receptor (R)/C5aR), or treated with a targeted complement inhibitor (CR2-Crry)...
December 30, 2016: Transplantation
https://www.readbyqxmd.com/read/28040452/delay-techniques-for-nipple-sparing-mastectomy-a-systematic-review
#18
REVIEW
Laurel S Karian, Paul J Therattil, Philip D Wey, Kevin T Nini
BACKGROUND: Rare but serious complications of nipple-sparing mastectomy (NSM) include necrosis of the nipple-areolar complex (NAC) and mastectomy skin flaps. NAC and mastectomy flap delay procedures are novel techniques designed to avoid these complications and may be combined with retroareolar biopsy as a first-stage procedure. We performed a systematic review of the literature to evaluate various techniques for NAC and mastectomy flap delay. METHODS: PubMed and Cochrane databases were searched from January 1975 through April 15, 2016...
November 29, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28033508/pathological-complete-response-in-invasive-breast-cancer-treated-by-skin-sparing-mastectomy-and-immediate-reconstruction-following-neoadjuvant-chemotherapy-and-radiation-therapy-comparison-between-immunohistochemical-subtypes
#19
J Barrou, M Bannier, M Cohen, E Lambaudie, A Gonçalves, P Bertrand, M Buttarelli, P Opinel, N Sterkers, A Tallet, C Zinzindohoué, G Houvenaeghel
CONTEXT: Even if neoadjuvant chemotherapy (NACT) and oncoplastic techniques have increased the breast conserving surgery rate, mastectomy is still a standard for multifocal or extensive breast cancers (BC). In the prospect of increasing breast reconstruction, an alternative therapeutic protocol was developed combining NACT with neoadjuvant radiation therapy (NART), followed by mastectomy with immediate breast reconstruction (IBR). The oncological safety of this therapeutic plan still needs further exploration...
December 26, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28027223/staged-suprapectoral-expander-implant-reconstruction-without-acellular-dermal-matrix-following-nipple-sparing-mastectomy
#20
Arthur H Salibian, Jay K Harness, Donald S Mowlds
BACKGROUND: Since the introduction of nipple-sparing mastectomy as an oncologically safe procedure for the treatment of breast cancer, reconstructive efforts for immediate staged expander/implant reconstruction have focused on submuscular implantation with or without acellular dermal matrix. Suprapectoral reconstruction without acellular dermal matrix has received little attention in the reconstructive literature of nipple-sparing mastectomy. METHODS: Between 2005 and 2015, 155 patients (250 breasts) underwent nipple-sparing mastectomy with prepectoral staged expander/implant reconstruction using thick mastectomy skin flaps without acellular dermal matrix...
January 2017: Plastic and Reconstructive Surgery
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