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NK cell and steroid use

Anna Hayden, Sujin Park, Dean Giustini, Agnes Y Y Lee, Luke Y C Chen
Most knowledge of hemophagocytic syndromes (HPSs) including hemophagocytic lymphohistiocytosis (HLH) is derived from pediatric studies; literature on adult HPS/HLH predominantly consists of small retrospective studies with clinical and methodological heterogeneity. The aims of this systematic scoping review were to provide an overview of existing literature on adult HPS/HLH, describe current practices in diagnosis and treatment, and propose priorities for future research. Articles from Ovid Medline, Embase and Pubmed (1975-2015) describing 10 or more unique adults (age>15years) with HPS/HLH were included...
May 20, 2016: Blood Reviews
Lydia Kwast, Daniëlle Fiechter, Laura Kruijssen, Rob Bleumink, Irene Ludwig, Marianne Bol-Schoenmakers, Joost Smit, Raymond Pieters
The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent responses to TNP-OVA. These results were indicative of the adjuvant potential of these drugs. The present study set out to evaluate the nature of this adjuvant potential by focusing on early immune changes in the spleen, by testing several drugs in the same experimental model...
July 2016: Journal of Immunotoxicology
Gabriella Fabbrocini, Sara Cacciapuoti, Rosanna Izzo, Massimo Mascolo, Stefania Staibano, Giuseppe Monfrecola
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
M G Danieli, Y Shoenfeld
Immunomodulation uses synthetic, natural and recombinant preparations to modify the immune response to a desired level, typically to treat specific autoimmune diseases, as will be discussed in this section. Rheumatoid arthritis (RA) is a common systemic autoimmune disease, affecting 1% of the population worldwide. Currently, a first-line disease-modifying therapy for RA is methotrexate; however, more than 40 monoclonal antibodies are in use or under investigation for the treatment of RA. This panoply of biological disease-modifying agents means that clinicians can make use of drugs with different mechanisms of action should one type become ineffective...
December 2014: Clinical and Experimental Immunology
Takumi Kumai, Kensuke Oikawa, Naoko Aoki, Shoji Kimura, Yasuaki Harabuchi, Hiroya Kobayashi
BACKGROUND: Epidermal growth factor receptor (EGFR)-targeted therapy has been widely accepted as a promising treatment for solid tumors. Steroid treatment is used to prevent adverse effect of anti-EGFR antibody; however, influence of steroids in the antitumor activity of targeted antibody remains poorly understood. Herein, we demonstrated the impact of steroids in induced antibody-dependent cellular cytotoxicity (ADCC) activity of natural killer (NK) cells by cetuximab. METHODS: Various numbers of NK cells from healthy donors were co-cultured with tumor and/or cetuximab with or without dexamethasone...
March 2016: Head & Neck
Krzysztof Rutkowski, Paweł Sowa, Joanna Rutkowska-Talipska, Anna Kuryliszyn-Moskal, Ryszard Rutkowski
Dehydroepiandrosterone (DHEA) and its sulfated form dehydroepiandrosterone sulfate (DHEAS) are the most abundant circulating steroid hormones in humans. In animal studies, their low levels have been associated with age-related involuntary changes, including reduced lifespan. Extrapolation of animal data to humans turned DHEA into a 'superhormone' and an 'anti-aging' panacea. It has been aggressively marketed and sold in large quantities as a dietary supplement. Recent double-blind, placebo-controlled human studies provided evidence to support some of these claims...
July 2014: Drugs
Greg Hodge, Sandra Hodge, Chien Li Holmes-Liew, Paul N Reynolds, Mark Holmes
BACKGROUND: Pro-inflammatory cytokines in T and natural killer T (NKT)-like cells increase with time post-transplant in otherwise stable patients, suggesting that some patients become relatively resistant to immunosuppressants such as glucocorticoids (GC). We hypothesized that GC receptor (GCR) would be down-regulated in peripheral blood pro-inflammatory T and NKT-like cells after lung transplantation and loss of GCR would correlate with time post-transplant. METHODS: Blood was collected from 17 stable lung transplant patients and 17 healthy, aged-matched controls...
September 2014: Journal of Heart and Lung Transplantation
Florian W R Vondran, Kai Timrott, Sonja Kollrich, Ann-Kristin Steinhoff, Alexander Kaltenborn, Harald Schrem, Juergen Klempnauer, Frank Lehner, Reinhard Schwinzer
Acute rejection (AR) remains a major cause for long-term kidney allograft failure. Reliable immunological parameters suitable to define the pre-transplant immune state and hence the individual risk of graft rejection are highly desired to preferably adapt the immunosuppressive regimen in advance. Donor and third party alloreactivities were determined by mixed lymphocyte cultures. Soluble forms of CD25, CD30, and CD44 were detected in patients' serum by ELISA. Various lymphocyte subpopulations were measured using flow cytometry...
September 2014: Clinical Transplantation
Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N Reynolds, Sandra Hodge
BACKGROUND: We have shown that chronic obstructive pulmonary disease (COPD) is associated with increased production of pro-inflammatory cytokines and the cytotoxic mediator, granzyme B by peripheral blood steroid resistant CD28nullCD137 + CD8+ T cells and granzyme B by NKT-like and NK cells. We hypothesized that we could target these pro-inflammatory/cytotoxic lymphocytes by inhibiting co-stimulation through CD137. METHODS: Isolated PBMC from patients with COPD and healthy controls were stimulated with phytohaemagglutinin (PHA) ± blocking anti-CD137 ± 10(-6) M methylprednislone (MP) (±stimulatory anti-CD137 ± control antibodies)...
2014: BMC Pulmonary Medicine
Lin Wang, Juxiang Huang, Minghu Jiang, Qingchun Chen, Zhenfu Jiang, Haitao Feng
We data-analyzed and constructed the high-expression CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) compared with low-expression (fold change ≥ 2) no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) in GEO data set, using integration of gene regulatory network inference method with gene ontology (GO). Our result showed that CAMK1 transport subnetwork upstream KCNQ3, LCN2, NKX2_5, NUP62, SORT1, STX1A activated CAMK1, and downstream CAMK1-activated AFP, ENAH, KPNA2, SLC4A3; CAMK1 signal subnetwork upstream BRCA1, DKK1, GPSM2, LEF1, NR5A1, NUP62, SORT1, SSTR5, TBL3 activated CAMK1, and downstream CAMK1-activated MAP2K6, SFRP4, SSTR5, TSHB, UBE2C in HCC...
November 2014: Cell Biochemistry and Biophysics
Mostafa F Gomaa, Abdellatif G Elkholy, Mourrad M El-Said, Nermine E Abdel-Salam
PURPOSE: To evaluate the efficacy of the use of oral Prednisolone and heparin versus the use of heparin alone in treatment of patients with unexplained recurrent miscarriage. METHODOLOGY: The study was a double-blind placebo randomized control trial conducted on 160 patients with unexplained recurrent miscarriage. Patients recruited were randomized into two groups. The first group received oral Prednisolone in addition to low dose aspirin and heparin, while the other group received a placebo in addition to low dose aspirin and heparin...
October 2014: Archives of Gynecology and Obstetrics
H Morimoto, K Ide, Y Tanaka, K Ishiyama, M Ohira, H Tahara, Y Teraoka, M Yamashita, T Abe, S Hashimoto, F Hirata, N Tanimine, Y Saeki, S Shimizu, H Sakai, T Yano, H Tashiro, H Ohdan
BACKGROUND: CXC motif chemokine 10 (CXCL10), known as interferon-γ-induced protein 10, is an inflammatory cytokine secreted by various cells in response to interferon-γ. CXCR3, the receptor of CXCL10, is predominantly expressed on activated T, B, natural killer, and dendritic cells, as well as macrophages. CXCR3 promotes chemotaxis upon binding CXCL10. Serum CXCL10 levels have recently attracted attention as a post-transplantation biomarker for graft rejection. However, the correlation between the degree of T cell response to allostimulation and CXCL10 levels remains unclear...
April 2014: Transplantation Proceedings
Peng-Fei Wang, Ke Huang, Jian-Pei Fang, Dun-Hua Zhou, Hai-Xia Guo, Yan-Yan Chen, Chun Chen, Yang Li
This study was aimed to explore the relation of Treg and invariant natural killer T (iNKT) cell reconstruction with acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children. According to the occurrence or absence of aGVHD, 29 pediatric patients who underwent allo-HSCT were firstly divided into two groups non-aGVHD and aGVHD group,then those patients with aGVHD were divided into steroid effective group and steroid resistant group according to their reaction to the steroid treatment...
April 2014: Zhongguo Shi Yan Xue Ye Xue za Zhi
Ritsuro Suzuki
Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKL) is one of the uncommon subtypes of malignant lymphoma, and predominantly occurs in the nasal or paranasal areas and less frequently in the skin. Previously, its prognosis was poor due to the expression of P-glycoprotein, which actively exports several anticancer agents outside the lymphoma cells. However, in recent years, novel therapeutic approaches such as simultaneous chemoradiotherapy or l-asparaginase-based regimens including SMILE (steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide) improved the response to therapy and survival of ENKL patients...
January 2014: Seminars in Hematology
Junhui Zhen, Qian Li, Yanji Zhu, Xiujun Yao, Li Wang, Aihua Zhou, Shuzhen Sun
BACKGROUND: Primary nephrotic syndrome (NS) is a common disease in children. Lipid nephrotoxicity and cellular immune dysfunction are known features of this disease. Recently, CXCL16 was found to participate in inflammation and mediate cellular uptake of lipids. Here, we investigated the involvement of CXCL16 in the occurrence and development of primary NS. METHODS: Serum CXCL16, blood lipids and albumin, 24-hour urine protein, interferon-γ and immune cells were detected in 25 children with steroid sensitive NS during their active nephrotic and remissive stages...
2014: Diagnostic Pathology
Greg Hodge, Sandra Hodge, Paul N Reynolds, Mark Holmes
BACKGROUND: We have shown that bronchiolitis obliterans syndrome (BOS) is associated with attenuated suppression of pro-inflammatory cytokines and granzyme B by steroid-resistant peripheral blood CD28nullCD137+ T cells and natural killer T (NKT)-like cells. We hypothesized that we could target these steroid-resistant lymphocytes by inhibiting costimulation through CD137. METHODS: Isolated peripheral blood mononuclear cells from transplant patients with stable lung function, patients with BOS, and healthy controls were stimulated with anti-CD3 with and without blocking anti-CD137 and with and without 10(-6) mol/liter methylprednisolone (MP) (with and without stimulatory anti-CD137)...
November 2013: Journal of Heart and Lung Transplantation
Naoko Asano, Seiichi Kato, Shigeo Nakamura
Epstein-Barr virus (EBV)-associated natural killer (NK)/T-cell lymphomas show a geographical predilection for Asian and South American populations and are rare in Western countries. They predominantly occur in extranodal sites, including the nasal or paranasal areas, and less frequently in the localized nodal lesion. Most of the tumor cells exhibit a cytotoxic phenotype, characterized primarily by the expression of granzyme B and perforin. EBV is usually detected in tumor cells by using EBV-encoded small RNA in situ hybridization (EBER), suggesting that EBV plays an important role in lymphomagenesis...
March 2013: Best Practice & Research. Clinical Haematology
J Stagg, J Galipeau
Cell therapy with mesenchymal stromal cells (MSCs) is the focus of intensive investigation. Several clinical trials, including large-scale placebo-controlled phase III clinical trials, are currently underway evaluating the therapeutic potential of autologous and allogeneic MSCs for treatment of catastrophic inflammatory diseases, including steroid-refractory graft-versus-host disease (GvHD), multiple sclerosis (MS) and Crohn's disease. MSCs are also being investigated as carriers of anti-cancer biotherapeutics...
June 2013: Current Molecular Medicine
Matthias Büchler, Hélène Longuet, Roxane Lemoine, Florence Herr, Philippe Gatault, Gilles Thibault, David Ternant, Christine Foulon, Bernadette Pilorge, Djamila Lemay, Crystal Sung, Jean-Michel Halimi, Christophe Baron, Yvon Lebranchu
Rabbit antithymocyte globulin (rATG; Thymoglobulin(®)) is currently used to prevent acute rejection in kidney transplantation. The dose and regimen of rATG have not been optimized. Moreover, the impact of different treatment regimens on T-cell phenotype reconstitution remains unknown. We conducted a prospective randomized study of 17 renal transplant patients to determine the pharmacokinetics of total and active (bound to human cells) rATG and T-cell phenotype reconstitution after rATG administration. Patients received rATG at a total dose of 6mg/kg, administered either as 1...
March 2013: Transplant Immunology
Sarah Nikiforow, Haesook T Kim, Bhavjot Bindra, Sean McDonough, Brett Glotzbecker, Philippe Armand, John Koreth, Vincent T Ho, Edwin P Alyea, Bruce R Blazar, Jerome Ritz, Robert J Soiffer, Joseph H Antin, Corey S Cutler
Steroid-refractory chronic graft-versus-host disease (cGVHD) carries a poor prognosis with no agreed upon algorithm for treatment. Because both B and T cells contribute to the pathophysiology of cGVHD, we conducted a phase I study in subjects with steroid-refractory cGVHD using the anti-CD52 antibody alemtuzumab to transiently deplete most mononuclear subsets. Three regimens were investigated in a 3+3 dose-escalation design: 3 mg × 6 (dose level 1), 3 mg × 1, then 10 mg × 5 (dose level 2) and 3 mg × 1, 10 mg × 1, then 30 mg × 4 (dose level 3) administered over 4 weeks...
May 2013: Biology of Blood and Marrow Transplantation
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