Tao Jiang, Nan Ruan, Pengcheng Luo, Qian Wang, Xiuxian Wei, Yi Li, Yue Dai, Li Lin, Jiagao Lv, Yu Liu, Cuntai Zhang
Aging is a gradual and irreversible natural process. With aging, the body experiences a functional decline, and the effects amplify the vulnerability to a range of age-related diseases, including neurodegenerative, cardiovascular, and metabolic diseases. Within the aging process, the morphology and function of mitochondria and the endoplasmic reticulum (ER) undergo alterations, particularly in the structure connecting these organelles known as mitochondria-associated membranes (MAMs). MAMs serve as vital intracellular signaling hubs, facilitating communication between the ER and mitochondria when regulating various cellular events, including calcium homeostasis, lipid metabolism, mitochondrial function, and apoptosis...
May 6, 2024: Ageing Research Reviews