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Mr thermometry

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https://www.readbyqxmd.com/read/27882240/t2-based-temperature-monitoring-in-bone-marrow-for-mr-guided-focused-ultrasound
#1
Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug, Viola Rieke
BACKGROUND: Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to monitor the temperature change in bone marrow during focused ultrasound ablation of bone lesions. METHODS: We investigated the dependence of T2 on temperature in ex vivo bovine yellow bone marrow at 3T and studied the influence of acquisition parameters on the T2 measurements...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27835808/evaluation-of-a-small-flat-rectangular-therapeutic-ultrasonic-transducer-intended-for-intravascular-use
#2
N Papadopoulos, G Menikou, M Yiannakou, C Yiallouras, K Ioannides, C Damianou
BACKGROUND: The aim of the proposed study was to evaluate the performance of a flat rectangular (2×10mm(2)) transducer operating at 4MHz. The intended application of this transducer is intravascular treatment of thrombosis and atherosclerosis. METHODS: The transducer's thermal capabilities were tested in two different gel phantoms. MR thermometry was used to demonstrate the thermal capabilities of this type of transducer. RESULTS: Temperature measurements demonstrated that this simple and small transducer adequately produced high temperatures, which can be utilized for therapeutic purposes...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27759913/accurate-mr-thermometry-by-hyperpolarized-129-xe
#3
Le Zhang, Alex Burant, Andrew McCallister, Victor Zhao, Karl M Koshlap, Simone Degan, Michael Antonacci, Rosa Tamara Branca
PURPOSE: To investigate the temperature dependence of the resonance frequency of lipid-dissolved xenon (LDX) and to assess the accuracy of LDX-based MR thermometry. METHODS: The chemical shift temperature dependence of water protons, methylene protons, and LDX was measured from samples containing tissues with varying fat contents using a high-resolution NMR spectrometer. LDX results were then used to acquire relative and absolute temperature maps in vivo and the results were compared with PRF-based MR thermometry...
October 19, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27699844/specialized-volumetric-thermometry-for-improved-guidance-of-mrgfus-in-brain
#4
Michael Marx, Pejman Ghanouni, Kim Butts Pauly
PURPOSE: MR thermometry is critical for safe and effective transcranial focused ultrasound. The current single-slice MR thermometry sequence cannot achieve all desired treatment monitoring requirements. We propose an approach in which the imaging requirements of different aspects of treatment monitoring are met by optimizing multiple sequences. METHODS: Imaging requirements were determined for three stages of MR-guided focused ultrasound brain treatment: 1) focal spot localization, 2) focal spot monitoring, and 3) background monitoring...
October 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27690660/stereotactic-robot-assisted-mri-guided-laser-thermal-ablation-of-radiation-necrosis-in-the-posterior-cranial-fossa-technical-note
#5
Alvin Y Chan, Diem Kieu T Tran, Amandip S Gill, Frank P K Hsu, Sumeet Vadera
Laser interstitial thermal therapy (LITT) is a minimally invasive procedure used to treat a variety of intracranial lesions. Utilization of robotic assistance with stereotactic procedures has gained attention due to potential for advantages over conventional techniques. The authors report the first case in which robot-assisted MRI-guided LITT was used to treat radiation necrosis in the posterior fossa, specifically within the cerebellar peduncle. The use of a stereotactic robot allowed the surgeon to perform LITT using a trajectory that would be extremely difficult with conventional arc-based techniques...
October 2016: Neurosurgical Focus
https://www.readbyqxmd.com/read/27688881/mr-thermometry-for-focused-ultrasound-monitoring-utilizing-model-predictive-filtering-and-ultrasound-beam-modeling
#6
Henrik Odéen, Scott Almquist, Joshua de Bever, Douglas A Christensen, Dennis L Parker
BACKGROUND: A major challenge in using magnetic resonance temperature imaging (MRTI) to monitor focused ultrasound (FUS) applications is achieving high spatio-temporal resolution over a large field of view (FOV). This is important to accurately monitor all ultrasound (US) power depositions. Magnetic resonance (MR) subsampling in conjunction with thermal model-based reconstruction of the MRTI utilizing Pennes bioheat transfer equation (PBTE) is one promising approach. The thermal properties used in the thermal model are often estimated from a pre-treatment, low-power sonication...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27687017/short-and-long-time-mr-signal-behavior-of-randomly-distributed-water-and-fat-numerical-simulations
#7
Mie K Lam, Chris J G Bakker, Chrit T W Moonen, Max A Viergever, Lambertus W Bartels
The MR time-signal behavior of water has been reported to be different on short and long time scales for systems of randomly distributed perturbers in water in the static dephasing regime. Up to now, the signal of the perturbers in such systems has not been taken into consideration. Water-fat emulsions are macroscopically homogeneous systems and can be considered as microscopically randomly distributed perturbing fat spheres embedded in water. In such water-fat systems, the signal of the perturber, fat, cannot be ignored...
September 30, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27597889/open-source-small-animal-magnetic-resonance-guided-focused-ultrasound-system
#8
Megan E Poorman, Vandiver L Chaplin, Ken Wilkens, Mary D Dockery, Todd D Giorgio, William A Grissom, Charles F Caskey
BACKGROUND: MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and blood-brain barrier opening. However, the large financial costs involved in developing preclinical MRgFUS systems represent a barrier to research groups interested in developing new techniques and applications. We aim to mitigate these challenges by detailing a validated, open-source preclinical MRgFUS system capable of delivering thermal and mechanical FUS in a quantifiable and repeatable manner under real-time MRI guidance...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27552745/kalman-filtered-bio-heat-transfer-model-based-self-adaptive-hybrid-magnetic-resonance-thermometry
#9
Yuxin Zhang, Shuo Chen, Kexin Deng, Bingyao Chen, Xing Wei, Jiafei Yang, Shi Wang, Kui Ying
To develop a self-adaptive and fast thermometry method by combining the original hybrid magnetic resonance thermometry method and the bio heat transfer equation (BHTE) model. The proposed Kalman filtered Bio Heat Transfer Model Based Self-adaptive Hybrid Magnetic Resonance Thermometry, abbreviated as KalBHT hybrid method, introduced the BHTE model to synthesize a window on the regularization term of the hybrid algorithm, which leads to a self-adaptive regularization both spatially and temporally with change of temperature...
August 18, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27524666/towards-real-time-thermometry-using-simultaneous-multislice-mri
#10
P T S Borman, C Bos, T de Boorder, B W Raaymakers, C T W Moonen, S P M Crijns
MR-guided thermal therapies, such as high-intensity focused ultrasound (MRgHIFU) and laser-induced thermal therapy (MRgLITT) are increasingly being applied in oncology and neurology. MRI is used for guidance since it can measure temperature noninvasively based on the proton resonance frequency shift (PRFS). For therapy guidance using PRFS thermometry, high temporal resolution and large spatial coverage are desirable. We propose to use the parallel imaging technique simultaneous multislice (SMS) in combination with controlled aliasing (CAIPIRINHA) to accelerate the acquisition...
September 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27520071/non-invasive-monitoring-of-branched-au-nanoparticle-mediated-photothermal-ablation
#11
Ken Zhao, Soojeong Cho, Daniel Procissi, Andrew C Larson, Dong-Hyun Kim
Nanoparticle-mediated photothermal therapy for treatment of different types of tumors has attracted tremendous attention in recent years. One major factor that drives this therapy is the ability to carefully control and prevent inadvertent damage to local tissues, while focusing therapeutic heating to specific regions of the tumor tissues. To this end, it is critical to generate efficient heating in the targeted tumors while monitoring the extent and distribution of heating. In our study, we demonstrated the photothermal heating properties of our synthesized branched Au nanoparticles (b-AuNPs) using non-invasive MR thermometry (MRT) techniques to assess its effects both in vitro and in vivo...
August 13, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27422012/optimization-of-single-voxel-mr-spectroscopy-sequence-parameters-and-data-analysis-methods-for-thermometry-in-deep-hyperthermia-treatments
#12
J Hartmann, J Gellermann, T Brandt, M Schmidt, S Pyatykh, J Hesser, O Ott, R Fietkau, C Bert
OBJECTIVE: The difference in the resonance frequency of water and methylene moieties of lipids quantifies in magnetic resonance spectroscopy the absolute temperature using a predefined calibration curve. The purpose of this study was the investigation of peak evaluation methods and the magnetic resonance spectroscopy sequence (point-resolved spectroscopy) parameter optimization that enables thermometry during deep hyperthermia treatments. MATERIALS AND METHODS: Different Lorentz peak-fitting methods and a peak finding method using singular value decomposition of a Hankel matrix were compared...
July 14, 2016: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/27418429/focal-point-determination-in-magnetic-resonance-guided-focused-ultrasound-using-tracking-coils
#13
Bryant T Svedin, Michael J Beck, J Rock Hadley, Robb Merrill, Joshua T de Bever, Bradley D Bolster, Allison Payne, Dennis L Parker
PURPOSE: To develop a method for rapid prediction of the geometric focus location in MR coordinates of a focused ultrasound (US) transducer with arbitrary position and orientation without sonicating. METHODS: Three small tracker coil circuits were designed, constructed, attached to the transducer housing of a breast-specific MR-guided focused US (MRgFUS) system with 5 degrees of freedom, and connected to receiver channel inputs of an MRI scanner. A one-dimensional sequence applied in three orthogonal directions determined the position of each tracker, which was then corrected for gradient nonlinearity...
July 15, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27370138/endoluminal-ultrasound-applicators-for-mr-guided-thermal-ablation-of-pancreatic-tumors-preliminary-design-and-evaluation-in-a-porcine-pancreas-model
#14
Matthew S Adams, Vasant A Salgaonkar, Juan Plata-Camargo, Peter D Jones, Aurea Pascal-Tenorio, Hsin-Yu Chen, Donna M Bouley, Graham Sommer, Kim Butts Pauly, Chris J Diederich
PURPOSE: Endoluminal ultrasound may serve as a minimally invasive option for delivering thermal ablation to pancreatic tumors adjacent to the stomach or duodenum. The objective of this study was to explore the basic feasibility of this treatment strategy through the design, characterization, and evaluation of proof-of-concept endoluminal ultrasound applicators capable of placement in the gastrointestinal (GI) lumen for volumetric pancreas ablation under MR guidance. METHODS: Two variants of the endoluminal applicator, each containing a distinct array of two independently powered transducers (10 × 10 mm 3...
July 2016: Medical Physics
https://www.readbyqxmd.com/read/27364227/surrogate-mri-markers-for-hyperthermia-induced-release-of-doxorubicin-from-thermosensitive-liposomes-in-tumors
#15
Michael Peller, Linus Willerding, Simone Limmer, Martin Hossann, Olaf Dietrich, Michael Ingrisch, Ronald Sroka, Lars H Lindner
The efficacy of systemically applied, classical anti-cancer drugs is limited by insufficient selectivity to the tumor and the applicable dose is limited by side effects. Efficacy could be further improved by targeting of the drug to the tumor. Using thermosensitive liposomes (TSL) as a drug carrier, targeting is achieved by control of temperature in the target volume. In such an approach, effective local hyperthermia (40-43°C) (HT) of the tumor is considered essential but technically challenging. Thus, visualization of local heating and drug release using TSL is considered an important tool for further improvement...
September 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27343436/autoadaptive-motion-modelling-for-mr-based-respiratory-motion-estimation
#16
Christian F Baumgartner, Christoph Kolbitsch, Jamie R McClelland, Daniel Rueckert, Andrew P King
Respiratory motion poses significant challenges in image-guided interventions. In emerging treatments such as MR-guided HIFU or MR-guided radiotherapy, it may cause significant misalignments between interventional road maps obtained pre-procedure and the anatomy during the treatment, and may affect intra-procedural imaging such as MR-thermometry. Patient specific respiratory motion models provide a solution to this problem. They establish a correspondence between the patient motion and simpler surrogate data which can be acquired easily during the treatment...
June 9, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27261569/mri-compatible-bone-phantom-for-evaluating-ultrasonic-thermal-exposures
#17
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
OBJECTIVE: The goal of the proposed study was the development of a magnetic resonance imaging (MRI) compatible bone phantom suitable for evaluating focused ultrasound protocols. MATERIALS AND METHODS: High resolution CT images were used to segment femur bone. The segmented model was manufactured with (Acrylonitrile Butadiene Styrene) ABS plastic using a 3-D printer. The surrounding skeletal muscle tissue was mimicked using an agar-silica-evaporated milk gel (2% w/v-2% w/v-40% v/v)...
September 2016: Ultrasonics
https://www.readbyqxmd.com/read/27228330/radiofrequency-ablation-mr-thermometry-and-high-spatial-resolution-mr-parametric-imaging-with-a-single-minimally-invasive-device
#18
M Arcan Ertürk, Shashank Sathyanarayana Hegde, Paul A Bottomley
Purpose To develop and demonstrate in vitro and in vivo a single interventional magnetic resonance (MR)-active device that integrates the functions of precise identification of a tissue site with the delivery of radiofrequency (RF) energy for ablation, high-spatial-resolution thermal mapping to monitor thermal dose, and quantitative MR imaging relaxometry to document ablation-induced tissue changes for characterizing ablated tissue. Materials and Methods All animal studies were approved by the institutional animal care and use committee...
December 2016: Radiology
https://www.readbyqxmd.com/read/27211258/fast-temperature-estimation-from-undersampled-k-space-with-fully-sampled-center-for-mr-guided-microwave-ablation
#19
Fuyixue Wang, Zijing Dong, Shuo Chen, Bingyao Chen, Jiafei Yang, Xing Wei, Shi Wang, Kui Ying
PURPOSE: This study aims to accelerate MR temperature imaging using the proton resonance frequency (PRF) shift method for real time temperature monitoring during thermal ablation. MATERIALS AND METHODS: The proposed method estimates temperature changes from undersampled k-space with a fully sampled center. This proposed algorithm is based on the hybrid multi-baseline and referenceless treatment image model and can be seen as an extension of the conventional k-space-based hybrid thermometry...
October 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27210733/drift-correction-for-accurate-prf-shift-mr-thermometry-during-mild-hyperthermia-treatments-with-mr-hifu
#20
Chenchen Bing, Robert M Staruch, Matti Tillander, Max O Köhler, Charles Mougenot, Mika Ylihautala, Theodore W Laetsch, Rajiv Chopra
UNLABELLED: There is growing interest in performing hyperthermia treatments with clinical magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) therapy systems designed for tissue ablation. During hyperthermia treatment, however, due to the narrow therapeutic window (41-45 °C), careful evaluation of the accuracy of proton resonant frequency (PRF) shift MR thermometry for these types of exposures is required. PURPOSE: The purpose of this study was to evaluate the accuracy of MR thermometry using a clinical MR-HIFU system equipped with a hyperthermia treatment algorithm...
September 2016: International Journal of Hyperthermia
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