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https://www.readbyqxmd.com/read/28427220/multiparametric-imaging-using-18f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#1
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment 18F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from 18F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427078/a-case-of-adult-metastatic-rhabdomyosarcoma-of-the-prostate-cured-by-long-term-chemotherapy-with-local-radiation
#2
Masato Konno, Koji Mitsuzuka, Shigeyuki Yamada, Shinichi Yamashita, Yasuhiro Kaiho, Akihiro Ito, Mika Watanabe, Yoichi Arai
A 32-year-old man visited our hospital due to urinary retention. Prostate-specific antigen was 13.7 ng/mL. Imaging examinations showed a large prostatic tumor and lung and internal iliac lymph node metastases. Transrectal biopsy confirmed embryonal rhabdomyosarcoma of the prostate classified as cT2bN1M1 (stage IV) by the International Rhabdomyosarcoma Study (IRS) Group staging system. Systemic chemotherapy was started according to the IRS III regimen 36, which consisted of 16 weeks of induction chemotherapy with radiation...
April 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28426728/pulmonary-vascular-volume-impaired-left-ventricular-filling-and-dyspnea-the-mesa-lung-study
#3
Carrie P Aaron, Eric A Hoffman, Joao A C Lima, Steven M Kawut, Alain G Bertoni, Jens Vogel-Claussen, Mohammadali Habibi, Katja Hueper, David R Jacobs, Ravi Kalhan, Erin D Michos, Wendy S Post, Martin R Prince, Benjamin M Smith, Bharath Ambale-Venkatesh, Chia-Ying Liu, Filip Zemrak, Karol E Watson, Matthew Budoff, David A Bluemke, R Graham Barr
BACKGROUND: Evaluation of impaired left ventricular (LV) filling has focused on intrinsic causes of LV dysfunction; however, pulmonary vascular changes may contribute to reduced LV filling and dyspnea. We hypothesized that lower total pulmonary vascular volume (TPVV) on computed tomography (CT) would be associated with dyspnea and decrements in LV end-diastolic volume, particularly among ever-smokers. METHODS: The Multi-Ethnic Study of Atherosclerosis recruited adults without clinical cardiovascular disease in 2000-02...
2017: PloS One
https://www.readbyqxmd.com/read/28423973/neurological-involvement-of-igg4-related-disease-description-of-a-case-and-review-of-the-literature
#4
Marco Varrassi, Camilla Gianneramo, Francesco Arrigoni, Paolo Cerrone, Patrizia Sucapane, Carmine Marini, Alessandra Splendiani
IgG4-related disease is a recently discovered pathological entity, histologically characterised by fibrosis and IgG4-positive plasma cell infiltration. This condition may virtually involve every site of the organism, with a various range of clinical presentations. The most commonly affected organ is the pancreatic gland, but it can also involve the biliary tract, salivary and lacrimal glands, kidneys, orbital tissues, lymph nodes, lungs and many others. More recently, IgG4-related disease has been demonstrated to involve, in rare cases, also the central nervous system, with a pattern mainly characterised by hypertrophic pachymeningitis...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28422070/one-year-follow-up-risk-assessment-in-skh-1-mice-and-wounds-treated-with-an-argon-plasma-jet
#5
Anke Schmidt, Thomas von Woedtke, Jan Stenzel, Tobias Lindner, Stefan Polei, Brigitte Vollmar, Sander Bekeschus
Multiple evidence in animal models and in humans suggest a beneficial role of cold physical plasma in wound treatment. Yet, risk assessment studies are important to further foster therapeutic advancement and acceptance of cold plasma in clinics. Accordingly, we investigated the longterm side effects of repetitive plasma treatment over 14 consecutive days in a rodent full-thickness ear wound model. Subsequently, animals were housed for 350 days and sacrificed thereafter. In blood, systemic changes of the proinflammatory cytokines interleukin 1β and tumor necrosis factor α were absent...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28419645/diagnostic-performance-of-different-imaging-modalities-in-the-assessment-of-distant-metastasis-and-local-recurrence-of-tumor-in-patients-with-non-small-cell-lung-cancer
#6
Yoshiharu Ohno, Takeshi Yoshikawa, Yuji Kishida, Shinichiro Seki, Hisanobu Koyama, Masao Yui, Yoshimori Kassai, Kota Aoyagi, Shigeo Kaminaga, Kazuro Sugimura
PURPOSE: To compare the diagnostic performance of positron emission tomography with [18F] fluoro-2-deoxy-glucose (FDG-PET) coregistered with magnetic resonance imaging (FDG-PET/MRI), MRI with and without diffusion-weighted imaging (DWI), FDG-PET fused with computed tomography (FDG-PET/CT) with brain contrast-enhanced (CE-) MRI, and routine radiological examination for assessment of postoperative recurrence in nonsmall-cell lung cancer (NSCLC) patients. MATERIALS AND METHODS: 96 consecutive postoperative NSCLC patients (52 men, 44 women; mean age 72 years) prospectively underwent whole-body 3T MRI with and without DWI; PET/CTs and routine radiological examinations consisted of CE-brain MRI, whole-body CE-CT, and bone scintigraphy...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28419635/canine-histiocytic-sarcoma-presenting-as-a-target-lesion-on-brain-magnetic-resonance-imaging-and-as-a-solitary-pulmonary-mass
#7
Jill Hicks, Renee Barber, Bronwen Childs, Shannon Gm Kirejczyk, Elizabeth W Uhl
A 6-year-old spayed female miniature schnauzer presented with generalized seizures and progressive multifocal intracranial neurologic disease. Thoracic radiographs and computed tomography (CT) revealed a large solitary pulmonary mass within the right cranial lung lobe. On brain magnetic resonance imaging (MRI), a solitary intraparenchymal mass within the left piriform lobe had a "target" appearance on both pre- and postcontrast sequences. Cerebrospinal fluid was unremarkable and histopathology indicated both masses represented histiocytic sarcoma...
April 17, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28415747/comparison-of-gadolinium-enhanced-mri-and-18fdg-pet-pet-ct-for-the-diagnosis-of-brain-metastases-in-lung-cancer-patients-a-meta-analysis-of-5-prospective-studies
#8
Ye Li, Guanqiao Jin, Danke Su
OBJECTIVE: We undertook this meta-analysis to compare the significance of Gadolinium-enhanced MRI and 18FDG PET/PET-CT for diagnosing brain metastases of lung cancer patients. RESULTS: Five articles comprising 941 patients were included for analysis. The sensitivities with 95% confidence interval for PET/PET-CT and MRI were 0.21 (0.13 - 0.32) and 0.77 (95% CI = 0.60 - 0.89), specificities were 1.00 (0.99 - 1.00) and 0.99 (0.97 - 1.00), and the areas under curve were 0...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415581/tumor-physiological-changes-during-hypofractionated-stereotactic-body-radiation-therapy-assessed-using-multi-parametric-magnetic-resonance-imaging
#9
Heling Zhou, Zhang Zhang, Rebecca Denney, Jessica S Williams, Jeni Gerberich, Strahinja Stojadinovic, Debabrata Saha, John M Shelton, Ralph P Mason
Radiation therapy is a primary treatment for non-resectable lung cancer and hypoxia is thought to influence tumor response. Hypoxia is expected to be particularly relevant to the evolving new radiation treatment scheme of hypofractionated stereotactic body radiation therapy (SBRT). As such, we sought to develop non-invasive tools to assess tumor pathophysiology and response to irradiation. We applied blood oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) MRI, together with dynamic contrast enhanced (DCE) MRI to explore the longitudinal effects of SBRT on tumor oxygenation and vascular perfusion using A549 human lung cancer xenografts in a subcutaneous rat model...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415059/-a-case-of-slowly-progressive-brain-metastasis-with-minor-bleeding-after-removal-of-and-chemotherapy-for-non-small-cell-lung-cancer
#10
Hiroshi Matsufuji, Eri Shiozaki, Yasutaka Nakatake, Koichi Yoshida, Kensaku Kamada, Takayuki Matsuo
Of all brain metastases, the most common primary lesion is derived from the lung. These types of metastases enlarge aggressively with unfavorable prognoses. We report the case of a 75-year-old male patient who had a history of pulmonary resection for Stage IA non-small cell lung cancer(NSCLC), and received chemotherapy. One year after NSCLC surgery, he experienced a cardiogenic cerebral infarction, and anticoagulant therapy was initiated. Mass lesions with hemorrhage were detected bilaterally in the frontal lobes through magnetic resonance imaging three years after the NSCLC surgery...
April 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28413671/paraneoplastic-limbic-encephalitis-in-a-patient-with-extensive-disease-small-cell-lung-cancer
#11
Sebastian Ochenduszko, Bartosz Wilk, Joanna Dabrowska, Izabela Herman-Sucharska, Anna Dubis, Miroslawa Puskulluoglu
Paraneoplastic limbic encephalitis (PLE) is a rare disorder infrequently accompanying malignancy, coexisting in ~50% of the cases with small-cell lung cancer (SCLC). The pathomechanism of PLE is considered to be immune-mediated, with production of specific anti-Hu antibodies and activation of T-cells directed against onconeural antigens present on both tumor cells and neurons. We herein report the case of a 50-year-old male patient who, prior to being diagnosed with SCLC, presented with typical symptoms of PLE (seizures, subacute cognitive dysfunction with severe memory impairment, anxiety and hallucinations)...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413660/dramatic-intracranial-response-to-osimertinib-in-a-poor-performance-status-patient-with-lung-adenocarcinoma-harboring-the-epidermal-growth-factor-receptor-t790m-mutation-a-case-report
#12
Takehiro Uemura, Tetsuya Oguri, Minami Okayama, Hiromi Furuta, Yoshihiro Kanemitsu, Osamu Takakuwa, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Akio Niimi
We herein report a case of dramatic intracranial response to osimertinib in a poor performance status patient with lung adenocarcinoma harboring the epidermal growth factor receptor (EGFR) T790M mutation encoded in exon 20. The patient was a 59-year-old woman with EGFR exon 19 deletion-positive lung adenocarcinoma, who relapsed with multiple brain metastases. Computed tomography-guided biopsy of the left pleural tumor revealed adenocarcinoma harboring an EGFR exon 19 deletion and an EGFR T790M mutation encoded in exon 20...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28413557/c2-primary-leiomyoma-in-an-immunocompetent-woman-a-case-report-and-review-of-literature
#13
Mohana Rao Patibandla, Madhukar T Nayak, A K Purohit, Megha Uppin, Sundaram Challa, Gokul Chowdary Addagada, Manisha Nukavarapu
Clinical case report and review of the literature. This is the first case of primary leiomyoma in an immunocompetent woman without previous history of uterine leiomyoma being reported in the literature to the best of our knowledge. Leiomyoma, a type of smooth muscle cell tumor, involving the vertebra is extremely rare. There were very few primary leiomyoma in patients with AIDS or in the immune-suppressed patients. This 48-year-old female came with H/o neck pain, weakness and bladder retention. On examination, tone increased in all four limbs, power on the right side of the limbs 4/5, power on the left upper limb 0/5, lower limb 3/5, left plantar was up going, decreased sensation over the left second cervical vertebra (C2) dermatome and all modalities decreased below C2...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413551/alveolar-soft-part-sarcoma-with-brain-metastases
#14
Vinodh Vayara Perumall, Rahmat Harun, Pulivendhan Sellamuthu, Mohd Shariman Md Shah
Metastatic tumors are the most common mass lesions in the brain. This case reports a rare form of sarcoma with metastasis to the brain. The appropriate management of a patient with metastatic alveolar soft part sarcoma to the brain is discussed. Author describes a 32-year-old gentleman diagnosed with primary tumor at gluteus and distant metastases at lower lobe of right lung and the brain. Histopathology proves diagnosis as alveolar soft part sarcoma. Craniotomy with excision of brain lesion was done. Repeated magnetic resonance imaging of the brain after 2 months showed rapidly growing new lesions...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28411250/visualising-early-lung-disease-in-cf-the-emergence-of-mri
#15
EDITORIAL
Jane C Davies
No abstract text is available yet for this article.
April 14, 2017: Thorax
https://www.readbyqxmd.com/read/28403885/lung-structure-and-function-similarities-between-primary-ciliary-dyskinesia-and-mild-cystic-fibrosis-a-pilot-study
#16
Marco Maglione, Silvia Montella, Carmine Mollica, Vincenzo Carnovale, Paola Iacotucci, Fabiola De Gregorio, Antonella Tosco, Mariarosaria Cervasio, Valeria Raia, Francesca Santamaria
BACKGROUND: Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are increasingly compared. There are no chest magnetic resonance imaging (MRI) comparative studies of PCD and CF. We assessed clinical, functional, microbiological and MRI findings in PCD and mild CF patients in order to evaluate different expression of lung disease. METHODS: Twenty PCD (15.1 years) and 20 CF subjects with mild respiratory impairment (16 years, 70% with pancreatic insufficiency) underwent MRI, spirometry, and sputum cultures when clinically stable...
April 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28398665/both-a-frameshift-and-a-missense-mutation-of-the-stra6-gene-observed-in-an-infant-with-the-matthew-wood-syndrome
#17
Samantha Sadowski, Nicolas Chassaing, Zuzanna Gaj, Ewa Czichos, Jan Wilczynski, Dorota Nowakowska
BACKGROUND: The Matthew-Wood syndrome is associated with mutations of the STRA6 gene. It combines a pulmonary agenesis/hypoplasia; microphthalmia/anophthalmia; congenital cardiac, digestive, and urogenital malformations; and diaphragmatic defects. CASE: A 23-year-old nulliparous woman was referred to our center after a fetal ultrasound examination at 26 weeks of pregnancy revealed an abnormal head shape, a heart malformation, multiple cysts in both kidneys, and dilated ureters...
March 1, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28396997/diffusion-weighted-dw-mri-in-lung-cancers-adc-test-retest-repeatability
#18
Alex Weller, Marianthi Vasiliki Papoutsaki, John C Waterton, Arturo Chiti, Sigrid Stroobants, Joost Kuijer, Matthew Blackledge, Veronica Morgan, Nandita M deSouza
PURPOSE: To determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement precision. METHODS: Thirty malignant lung lesions >2 cm in size (23 patients) were scanned on two occasions, using echo-planar-Diffusion-Weighted (DW)-MRI to derive whole-tumour ADC (b = 100, 500 and 800smm(-2)). Scanning was performed at 4 institutions (3 MRI vendors)...
April 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28396921/mri-findings-of-chronic-abruption-oligohydramnios-sequence-caos-report-of-three-cases
#19
Yasuhisa Kurata, Aki Kido, Sachiko Minamiguchi, Eiji Kondoh, Kaori Togashi
Chronic abruption-oligohydramnios sequence (CAOS), characterized by chronic vaginal hemorrhage and oligohydramnios, is a rare clinical condition of pregnancy. Because CAOS is associated with preterm delivery and lung injury to the infant, it is a major clinical concern. This report describes three CAOS cases which presented characteristic MRI findings reflecting CAOS pathological mechanisms and pathological findings. First, in all cases, the placenta detached from the uterus at the peripheral portion of the placenta because of placental marginal hematoma...
April 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28394689/underlying-adenocarcinoma-of-the-lung-metastasizing-to-the-proximal-phalanx-of-the-foot-causing-complex-regional-pain-syndromea-case-report
#20
Sam Bazrafshan, Maria Pacheco, Julio C Ortiz
We report an unusual case of adenocarcinoma of the lung metastasizing to the proximal phalanx of the third digit in a 56-year-old woman with overlying complex regional pain syndrome. The patient was initially treated for neuroma, fracture, and neuropathic pain with no improvement over a 4-month period before presenting to the emergency department for left third digit pain. Radiographic imaging showed substantial osteopenia and mottling; magnetic resonance imaging demonstrated an aggressive lesion to the proximal phalanx...
March 2017: Journal of the American Podiatric Medical Association
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