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Lung mri

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https://www.readbyqxmd.com/read/28545684/mri-of-cystic-fibrosis-lung-manifestations-sequence-evaluation-and-clinical-outcome-analysis
#1
O Scholz, T Denecke, J Böttcher, C Schwarz, H-J Mentzel, F Streitparth, M H Maurer, A Pfeil, A Huppertz, A Mehl, D Staab, B Hamm, D M Renz
AIM: To evaluate different magnetic resonance imaging (MRI) sequences for diagnosis of pulmonary manifestations of cystic fibrosis (CF) in comparison to chest computed tomography (CT), including an extended outcome analysis. MATERIALS AND METHODS: Twenty-eight patients with CF (15 male, 13 female, mean age 30.5±9.4 years) underwent CT and MRI of the lung. MRI (1.5 T) included different T2- and T1-weighted sequences: breath-hold HASTE (half Fourier acquisition single shot turbo spin echo) and VIBE (volumetric interpolated breath-hold examination, before and after contrast medium administration) sequences and respiratory-triggered PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) sequences with and without fat signal suppression, and perfusion imaging...
May 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28543069/real-time-dynamic-mr-image-reconstruction-using-compressed-sensing-and-principal-component-analysis-cs-pca-demonstration-in-lung-tumor-tracking
#2
Bryson Dietz, Eugene Yip, Jihyun Yun, B Gino Fallone, Keith Wachowicz
PURPOSE: This work presents a real-time dynamic image reconstruction technique, that combines compressed sensing and principal component analysis (CS-PCA), to achieve real-time adaptive radiotherapy with the use of a linac-magnetic resonance imaging system. METHODS: Six retrospective fully sampled dynamic data sets of patients diagnosed with non-small cell lung cancer were used to investigate the CS-PCA algorithm. Using a database of fully sampled k-space, principal components (PC's) were calculated to aid in the reconstruction of undersampled images...
May 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28542649/evaluation-of-connectivity-map-discovered-celastrol-as-a-radiosensitizing-agent-in-a-murine-lung-carcinoma-model-feasibility-study-of-diffusion-weighted-magnetic-resonance-imaging
#3
Hong Young Jun, Tae-Hoon Kim, Jin Woo Choi, Young Hwan Lee, Kang Kyoo Lee, Kwon-Ha Yoon
This study was designed to identify potential radiosensitizing (RS) agents for combined radio- and chemotherapy in a murine model of human lung carcinoma, and to evaluate the in vivo effect of the RS agents using diffusion-weighted magnetic resonance imaging (DW-MRI). Radioresistance-associated genes in A549 and H460 cells were isolated on the basis of their gene expression profiles. Celastrol was selected as a candidate RS by using connectivity mapping, and its efficacy in lung cancer radiotherapy was tested...
2017: PloS One
https://www.readbyqxmd.com/read/28529743/omental-synovial-sarcoma-mimicking-an-ovarian-malignancy-a-case-report
#4
Naoyuki Iwahashi, Yoko Deguchi, Yuko Horiuchi, Kazuhiko Ino, Kenichi Furukawa
Synovial sarcoma is clinically rare, and cases of synovial sarcoma arising in the omentum are particularly rare. Only 3 cases have been reported in the literature to dtae, and they were associated with a poor prognosis. We herein report a rare case of aggressive primary omental synovial sarcoma presenting as an ovarian malignancy. A 53-year-old multigravida woman was referred to our hospital due to progressive abdominal distension. Magnetic resonance imaging revealed a large heterogeneous mass with an irregular component occupying the lower abdominal cavity, with an intact uterus...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28529640/lung-cancer-targeting-peptides-with-multi-subtype-indication-for-combinational-drug-delivery-and-molecular-imaging
#5
Yi-Hsuan Chi, Jong-Kai Hsiao, Ming-Huang Lin, Chen Chang, Chun-Hsin Lan, Han-Chung Wu
Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (LCC) or small cell lung cancer (SCLC). Therefore, we aimed to identify targeting peptides with diagnostic and therapeutic utility that possess broad subtype specificity for SCLC and non-small cell lung cancer (NSCLC)...
2017: Theranostics
https://www.readbyqxmd.com/read/28528469/multiple-sclerosis-treatment-with-fingolimod-profile-of-non-cardiologic-adverse-events
#6
REVIEW
Yara Dadalti Fragoso
Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. The drug is safe and effective, and its first hours of use are associated with related to S1P receptors in the heart...
May 20, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28523317/mri-as-indicator-of-pulmonary-tuberculosis-activity-from-morphological-to-molecular-level-assessment-a-case-report
#7
Maria Teodora Antuaneta Buzan, Hanelore Herta, Mihaela Maria Coman, Daniela Homorodean, Silviu Andrei Sfrângeu, Carmen Monica Pop
We present the case of an adult patient with active post-primary pulmonary tuberculosis (TB) and discuss specific morphological and textural aspects found at high-field magnetic resonance imaging (MRI) of the lung. The 42-year-old man, heavy smoker, undertook a routine employment medical examination and was admitted to a referral pulmonology and TB center due to the abnormal findings seen on his chest radiography. The patient presented nonspecific symptoms, bilateral bronchial breath at pulmonary auscultation, inflammatory syndrome on the laboratory blood tests and positive sputum smears for acid-fast bacilli, which together with the typical aspect on the chest radiography lead to a diagnosis of post-primary pulmonary TB and administration of specific medication...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28523162/a-preliminary-exploration-of-the-intravoxel-incoherent-motion-applied-in-the-preoperative-evaluation-of-mediastinal-lymph-node-metastasis-of-lung-cancer
#8
Xin Ye, Shuo Chen, Yaru Tian, Bin You, Wenqian Zhang, Yan Zhao, Tao Jiang, Bin Hu, Hui Li
BACKGROUND: The aim of this study was to investigate the diagnostic value of the intravoxel incoherent motion (IVIM) for distinguishing non-metastatic from metastatic mediastinal lymph nodes in lung cancer. METHODS: IVIM-diffusion weighted imaging (DWI) exams were performed preoperatively on 66 patients with lung cancer from October 2015 to June 2016 in Beijing Chao-Yang Hospital, Capital Medical University. Fifty patients underwent enhanced chest computed tomography (CT) in our hospital, while the other 16 patients already had enhanced chest CT images when they were admitted...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28520778/texture-analysis-using-proton-density-and-t2-relaxation-in-patients-with-histological-usual-interstitial-pneumonia-uip-or-nonspecific-interstitial-pneumonia-nsip
#9
Maria T A Buzan, Andreas Wetscherek, Claus Peter Heussel, Michael Kreuter, Felix J Herth, Arne Warth, Hans-Ulrich Kauczor, Carmen Monica Pop, Julien Dinkel
OBJECTIVES: The purpose of our study was to assess proton density (PD) and T2 relaxation time of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) and to evaluate their utility in differentiating the two patterns. Furthermore, we aim to investigate whether these two parameters could help differentiate active-inflammatory and stable-fibrotic lesions in NSIP. METHODS: 32 patients (mean age: 69 years; M:F, 1:1) with pathologically proven disease (UIP:NSIP, 1:1), underwent thoracic thin-section multislice CT scan and 1...
2017: PloS One
https://www.readbyqxmd.com/read/28516043/quantification-of-regional-deformation-of-the-lungs-by-non-rigid-registration-of-three-dimensional-contrast-enhanced-magnetic-resonance-imaging
#10
Jiaxin Shao, Peng Hu
BACKGROUND: Assessment of lung function is vital for the diagnosis of a variety of pathological conditions. Research has been proposed to study pulmonary mechanics and kinematics using two-dimensional (2D) magnetic resonance imaging (MRI). This allows estimation of regional lung tissue mechanics but is limited to 2D information. An approach based on three-dimensional (3D) contrast-enhanced MR angiogram of pulmonary blood vessels and a non-rigid image registration technique is proposed for quantification of lung regional deformations, which can potentially be used for assessment of pulmonary parenchymal mechanics and regional ventilation for disease diagnosis without ionizing radiation...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28515948/cerebral-air-embolism-associated-with-penetrating-lung-injury-a-case-report-and-review-of-the-literature
#11
Ayumu Yamaoka, Kei Miyata, Eichi Narimatsu, Eiji Sakawaki, Sonoko Sakawaki, Suguru Hirayama, Shuji Uemura, Naoya Yama
CASE: A 44-year-old man intentionally stabbed himself in the anterior neck and left thorax with a fruit knife. Physical examination revealed two open wounds entering the thoracic cavity in the front chest, and a stab wound entering the trachea at the neck. Two chest tubes were initially inserted for the left lung injury with open hemopneumothorax. Nevertheless, the worsening oxygenation required positive pressure ventilation (PPV) with endotracheal intubation. OUTCOME: Right hemiparesis was found during weaning from PPV...
April 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/28514950/lung-function-imaging-methods-in-cystic-fibrosis-pulmonary-disease
#12
REVIEW
Magdalena Kołodziej, Michael J de Veer, Marian Cholewa, Gary F Egan, Bruce R Thompson
Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised information. High Resolution Computed Tomography (HRCT) is a well-established current 'gold standard' method for monitoring lung anatomical changes in Cystic Fibrosis patients. HRCT provides excellent morphological information, however, the X-ray radiation dose can become significant if multiple scans are required to monitor chronic diseases such as cystic fibrosis...
May 17, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28514760/clinical-study-of-99mtc-3p-rgd2-peptide-imaging-in-osteolytic-bone-metastasis
#13
Guoqiang Shao, Wei Gu, Muhong Guo, Shiming Zang, Jinjing Fu, Shuang Liu, Feng Wang, Zizheng Wang
OBJECTIVE: To investigate the value of integrin αvβ3 targeted imaging with 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfk)]2 (99mTc-3P-RGD2) as a radiotracer in dectecting osteolytic bone metastases. METHODS: This is a retrospective study involving a cohort of 69 consecutive patients including 59 with lung cancer and 10 with other cancers. Patients were required to receive whole body scan (WBS) and regional SPECT/CT imaging with 99mTc-3P-RGD2 (RGD imaging) and 99mTc-MDP (MDP imaging) as a radiotracer successively within days...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514304/diagnostic-and-clinical-application-value-of-magnetic-resonance-imaging-mri-for-progressive-massive-fibrosis-of-coal-worker-pneumoconiosis-case-reports
#14
Lansheng Zhang, Chun Wang, Qiuyue Yan, Tao Zhang, Zhengxiang Han, Guan Jiang
RATIONALE: Using magnetic resonance imaging (MRI), we diagnosed pneumoconiosis by identifying the content and distribution of hydrogen protons in the water molecules in different tissues and lesions. PATIENT CONCERNS: 25 cases of CWP patients with progressive massive fibrosis (PMF) lesions. DIAGNOSES: Patients were correctly diagnosed, with one case each of Phase I and II pneumoconiosis and 23 cases of Phase III pneumoconiosis. INTERVENTIONS: None...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28508450/simultaneous-assessment-of-both-lung-morphometry-and-gas-exchange-function-within-a-single-breath-hold-by-hyperpolarized-129-xe-mri
#15
Jianping Zhong, Huiting Zhang, Weiwei Ruan, Junshuai Xie, Haidong Li, He Deng, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou
During the measurement of hyperpolarized (129) Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application...
May 16, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28506908/effects-of-the-fibroblast-activation-protein-inhibitor-pt100-in-a-murine-model-of-pulmonary-fibrosis
#16
Christine Egger, Catherine Cannet, Christelle Gérard, Thomas Suply, Iwona Ksiazek, Elizabeth Jarman, Nicolau Beckmann
Bleomycin (BLM) induced lung injury is detectable in C57BL/6 mice using magnetic resonance imaging (MRI). We investigated the effects of the fibroblast activation protein (FAP) inhibitor, PT100, in this model. BLM (0.5 mg/kg/day) was administered on days -7, -6, -5, -2, -1, 0 in the nostrils of male mice. PT100 (40 µg/mouse) or vehicle (0.9%NaCl) was dosed per os twice daily from day 1 to 14. MRI was performed before BLM and at days 0, 7 and 14. After the last MRI acquisition, animals were euthanised and the lungs harvested for histological and quantitative real-time polymerase chain reaction (qRT-PCR) analyses...
May 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28502684/metastatic-neuroendocrine-carcinoma-of-unknown-origin-arising-in-the-femoral-nerve-sheath
#17
Nicholas Candy, Adam Young, Kieren Allinson, Oliver Carr, Jason McMillen, Rikin Trivedi
Metastatic neuroendocrine carcinoma of unknown origin is a rare condition, usually presenting with lesions in the liver and/or lung. We present the first reported case of a metastatic neuroendocrine carcinoma of unknown origin arising in the femoral nerve sheath. MRI demonstrated what was thought to be a schwannoma in the left femoral nerve sheath in the proximal femoral triangle, immediately inferior to the anterior inferior iliac spine. At the time of operation, the tumour capsule was invading surrounding tissue as well as three trunks of the femoral nerve...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28498813/microwave-ablation-combined-with-attenuated-salmonella-typhimurium-for-treating-hepatocellular-carcinoma-in-a-rat-model
#18
Qing Zhao, Xudong Qu, Kai Liu, Huibin Shi, Guowei Yang, Bo Zhou, Liang Zhu, Wei Zhang, Zhiping Yan, Rong Liu, Sheng Qian, Jianhua Wang
We aim to investigate the safety and efficacy of microwave ablation (MWA) combined with attenuated Salmonella typhimurium strain VNP20009 in treating hepatocellular carcinoma. Portions of tumor tissues were orthotopically implanted in the livers of 40 male rats weighed 150~200 g to establish tumor models. Three weeks later, the rats were randomly divided into four groups: (A) MWA plus VNP20009 group; (B) MWA group; (C) VNP20009 group; and (D) control group. Incomplete MWA was performed (20~30 W, 1~2 min) after the hepatic carcinoma was properly exposed...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28497643/three-dimensional-ultrashort-echo-time-mri-and-short-t2-images-generated-from-subtraction-for-determination-of-tumor-burden-in-lung-cancer-preclinical-investigation-in-transgenic-mice
#19
Andreas Müller, Philippe Jagoda, Peter Fries, Stefan Gräber, Robert Bals, Arno Buecker, Christopher Jungnickel, Christoph Beisswenger
PURPOSE: To investigate the potential of 3D ultrashort echo time MRI and short T2 images generated by subtraction for determination of total tumor burden in lung cancer. METHODS: As an animal model of spontaneously developing non-small cell lung cancer, the K-rasLA1 transgenic mouse was used. Three-dimensional MR imaging was performed with radial k-space acquisition and echo times of 20 µs and 1 ms. For investigation of the short T2 component in the recorded signal, subtraction images were generated from these data sets and used for consensus identification of tumors...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28494796/a-malignant-solitary-fibrous-tumour-arising-from-the-first-lumbar-vertebra-and-mimicking-an-osteosarcoma-a-case-report
#20
Naoki Oike, Hiroyuki Kawashima, Akira Ogose, Tetsuo Hotta, Toru Hirano, Takashi Ariizumi, Tetsuro Yamagishi, Hajime Umezu, Shoichi Inagawa, Naoto Endo
BACKGROUND: A solitary fibrous tumour (SFT) is an unusual neoplasm typically found in soft tissues. Although SFTs can arise in the bones, they very rarely arise in the vertebral arch. Here, we describe a case of a SFT that arose in the vertebral arch of the first lumbar (L1) spinal vertebrae and mimicked osteosarcoma. CASE PRESENTATION: A 49-year-old woman presented with a 2-month history of lower back pain and a lumbar region mass. Magnetic resonance imaging demonstrated a heterogeneously enhanced mass in the L1 vertebral arch...
May 11, 2017: World Journal of Surgical Oncology
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