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Hyperpolarized xenon

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https://www.readbyqxmd.com/read/28475947/depolarization-of-nuclear-spin-polarized-129-xe-gas-by-dark-rubidium-during-spin-exchange-optical-pumping
#1
M A Antonacci, Alex Burant, Wolfgang Wagner, Rosa T Branca
Continuous-flow spin-exchange optical pumping (SEOP) continues to serve as the most widespread method of polarizing (129)Xe for magnetic resonance experiments. Unfortunately, continuous-flow SEOP still suffers from as-yet unidentified inefficiencies that prevent the production of large volumes of xenon with a nuclear spin polarization close to theoretically calculated values. In this work we use a combination of ultra-low field nuclear magnetic resonance spectroscopy and atomic absorption spectroscopy (AAS) measurements to study the effects of dark Rb vapor on hyperpolarized (129)Xe in situ during continuous-flow SEOP...
June 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28384123/magnetic-resonance-imaging-with-hyperpolarized-agents-methods-and-applications
#2
Erin Adamson, Kai Ludwig, David Mummy, Sean B Fain
In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (<sup>3</sup>He) and xenon (<sup>129</sup>Xe) gases have reached the stage where they are under study in clinical research. HP <sup>129</sup>Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28298006/nuclear-magnetic-resonance-diffusion-pore-imaging-experimental-phase-detection-by-double-diffusion-encoding
#3
Kerstin Demberg, Frederik Bernd Laun, Johannes Windschuh, Reiner Umathum, Peter Bachert, Tristan Anselm Kuder
Diffusion pore imaging is an extension of diffusion-weighted nuclear magnetic resonance imaging enabling the direct measurement of the shape of arbitrarily formed, closed pores by probing diffusion restrictions using the motion of spin-bearing particles. Examples of such pores comprise cells in biological tissue or oil containing cavities in porous rocks. All pores contained in the measurement volume contribute to one reconstructed image, which reduces the problem of vanishing signal at increasing resolution present in conventional magnetic resonance imaging...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28247437/hyperpolarized-129xe-mri-sensor-for-h2s
#4
Shengjun Yang, Yaping Yuan, Weiping Jiang, Lili Ren, He Deng, Louis-S Bouchard, Xin Zhou, Maili Liu
A new MRI molecular sensor for hydrogen sulfide detection and imaging using the nuclear spin resonance of hyperpolarized 129Xe is developed. The designed MRI sensor employs cryptophane for NMR sensing together with an azide group serving as a reaction site. It demonstrates a 'proof-of-concept' that fluorescent H2S probe can be linked to a xenon-binding cryptophane and thereby converted into an MRI probe, which could provide a very generalizable template.
February 28, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28192930/mitochondria-targeted-and-intracellular-biothiol-triggered-hyperpolarized-129-xe-magnetofluorescent-biosensor
#5
Qingbin Zeng, Qianni Guo, Yaping Yuan, Yuqi Yang, Bin Zhang, Lili Ren, Xiaoxiao Zhang, Qing Luo, Maili Liu, Louis-S Bouchard, Xin Zhou
Biothiols such as gluthathione (GSH), cysteine (Cys), homocysteine (Hcy), and thioredoxin (Trx) play vital roles in cellular metabolism. Various diseases are associated with abnormal cellular biothiol levels. Thus, the intracellular detection of biothiol levels could be a useful diagnostic tool. A number of methods have been developed to detect intracellular thiols, but sensitivity and specificity problems have limited their applications. To address these limitations, we have designed a new biosensor based on hyperpolarized xenon magnetic resonance detection, which can be used to detect biothiol levels noninvasively...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28106110/in-vivo-detection-of-cucurbit-6-uril-a-hyperpolarized-xenon-contrast-agent-for-a-xenon-magnetic-resonance-imaging-biosensor
#6
Francis T Hane, Tao Li, Peter Smylie, Raiili M Pellizzari, Jennifer A Plata, Brenton DeBoef, Mitchell S Albert
The Hyperpolarized gas Chemical Exchange Saturation Transfer (HyperCEST) Magnetic Resonance (MR) technique has the potential to increase the sensitivity of a hyperpolarized xenon-129 MRI contrast agent. Signal enhancement is accomplished by selectively depolarizing the xenon within a cage molecule which, upon exchange, reduces the signal in the dissolved phase pool. Herein we demonstrate the in vivo detection of the cucurbit[6]uril (CB6) contrast agent within the vasculature of a living rat. Our work may be used as a stepping stone towards using the HyperCEST technique as a molecular imaging modality...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28048395/we-fg-206-07-assessing-the-lung-function-of-patients-with-non-small-cell-lung-cancer-using-hyperpolarized-xenon-129-dissolved-phase-mri
#7
K Qing, J Mugler, Q Chen
PURPOSE: Hyperpolarized xenon-129 dissolved-phase MRI is the first imaging technique that allows 3-dimensional regional mapping of ventilation and gas uptake by tissue and blood the in human lung. Multiple outcome measures can be produced from this method. Existing studies in subjects with major lung diseases compared to healthy controls demonstrated high sensitivities of this method to pulmonary physiological factors including ventilation, alveolar tissue density, surface-to-volume ratio, pulmonary perfusion and gas-blood barrier thickness...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047236/we-ab-202-07-ventilation-ct-voxel-level-comparison-with-hyperpolarized-helium-3-xenon-129-mri
#8
B Tahir, H Marshall, P Hughes, N Stewart, F Horn, G Collier, G Norquay, K Hart, J Swinscoe, M Hatton, J Wild, R Ireland
PURPOSE: To compare the spatial correlation of ventilation surrogates computed from inspiratory and expiratory breath-hold CT with hyperpolarized Helium-3 & Xenon-129 MRI in a cohort of lung cancer patients. METHODS: 5 patients underwent expiration & inspiration breath-hold CT. Xenon-129 & (1) H MRI were also acquired at the same inflation state as inspiratory CT. This was followed immediately by acquisition of Helium-3 & (1) H MRI in the same breath and at the same inflation state as inspiratory CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28026061/detection-of-smoke-induced-pulmonary-lesions-by-hyperpolarized-129-xe-diffusion-kurtosis-imaging-in-rat-models
#9
Weiwei Ruan, Jianping Zhong, Yu Guan, Yi Xia, Xiuchao Zhao, Yeqing Han, Xianping Sun, Shiyuan Liu, Chaohui Ye, Xin Zhou
PURPOSE: To demonstrate that hyperpolarized (HP) xenon diffusion kurtosis imaging (DKI) is able to detect smoke-induced pulmonary lesions in rat models. METHODS: Multi-b DKI with hyperpolarized xenon was used for the first time in five smoke-exposed rats and five healthy rats. Additionally, DKI with b values of up to 80 s/cm(2) were used in two healthy rats to probe the critical b value (a limit beyond which the DKI cannot describe the non-Gaussian diffusion). RESULTS: The mean apparent diffusion coefficient (Dapp ) and diffusion kurtosis (Kapp ) extracted by the DKI model revealed significant changes in the smoke-exposed rats compared with those in the control group (P = 0...
December 27, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27875871/remote-detection-of-hyperpolarized-129-xe-resonances-via-multiple-distant-dipolar-field-interactions-with-1-h
#10
Le Zhang, Michael Antonacci, Alex Burant, Karl M Koshlap, Rosa Tamara Branca
A remote detection scheme utilizing the distant dipolar field interaction between two different spin species was proposed by Granwehr et al. [J. Magn. Reson. 176(2), 125 (2005)]. In that sequence (1)H spins were detected indirectly via their dipolar field interaction with (129)Xe spins, which served as the sensing spins. Here we propose a modification of the proposed detection scheme that takes advantage of the longer T1 relaxation time of xenon to create a long lasting dipolar field with which the fast relaxing (1)H spins are allowed to interact many times during a single acquisition...
November 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27825066/diffusion-mediated-129-xe-gas-depolarization-in-magnetic-field-gradients-during-continuous-flow-optical-pumping
#11
Alex Burant, Rosa Tamara Branca
The production of large volumes of highly polarized noble gases like helium and xenon is vital to applications of magnetic resonance imaging and spectroscopy with hyperpolarized (HP) gas in humans. In the past ten years, (129)Xe has become the gas of choice due to its lower cost, higher availability, relatively high tissue solubility, and wide range of chemical shift values. Though near unity levels of xenon polarization have been achieved in-cell using stopped-flow Spin Exchange Optical Pumping (SEOP), these levels are currently unmatched by continuous-flow SEOP methods...
December 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27759913/accurate-mr-thermometry-by-hyperpolarized-129-xe
#12
Le Zhang, Alex Burant, Andrew McCallister, Victor Zhao, Karl M Koshlap, Simone Degan, Michael Antonacci, Rosa Tamara Branca
PURPOSE: To investigate the temperature dependence of the resonance frequency of lipid-dissolved xenon (LDX) and to assess the accuracy of LDX-based MR thermometry. METHODS: The chemical shift temperature dependence of water protons, methylene protons, and LDX was measured from samples containing tissues with varying fat contents using a high-resolution NMR spectrometer. LDX results were then used to acquire relative and absolute temperature maps in vivo and the results were compared with PRF-based MR thermometry...
October 19, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27732160/chronic-obstructive-pulmonary-disease-lobar-analysis-with-hyperpolarized-129-xe-mr-imaging
#13
Tahreema N Matin, Najib Rahman, Annabel H Nickol, Mitchell Chen, Xiaojun Xu, Neil J Stewart, Tom Doel, Vicente Grau, James M Wild, Fergus V Gleeson
Purpose To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ((129)Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized (129)Xe MR imaging at 1...
March 2017: Radiology
https://www.readbyqxmd.com/read/27707585/the-role-of-hyperpolarized-129-xenon-in-mr-imaging-of-pulmonary-function
#14
REVIEW
Lukas Ebner, Jeff Kammerman, Bastiaan Driehuys, Mark L Schiebler, Robert V Cadman, Sean B Fain
In the last two decades, functional imaging of the lungs using hyperpolarized noble gases has entered the clinical stage. Both helium ((3)He) and xenon ((129)Xe) gas have been thoroughly investigated for their ability to assess both the global and regional patterns of lung ventilation. With advances in polarizer technology and the current transition towards the widely available (129)Xe gas, this method is ready for translation to the clinic. Currently, hyperpolarized (HP) noble gas lung MRI is limited to selected academic institutions; yet, the promising results from initial clinical trials have drawn the attention of the pulmonary medicine community...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27662575/hyperpolarized-129xenon-magnetic-resonance-imaging-to-quantify-regional-ventilation-differences-in-mild-to-moderate-asthma-a-prospective-comparison-between-semiautomated-ventilation-defect-percentage-calculation-and-pulmonary-function-tests
#15
Lukas Ebner, Mu He, Rohan S Virgincar, Timothy Heacock, Suryanarayanan S Kaushik, Matthew S Freemann, H Page McAdams, Monica Kraft, Bastiaan Driehuys
OBJECTIVES: The aim of this study was to investigate ventilation in mild to moderate asthmatic patients and age-matched controls using hyperpolarized (HP) Xenon magnetic resonance imaging (MRI) and correlate findings with pulmonary function tests (PFTs). MATERIALS AND METHODS: This single-center, Health Insurance Portability and Accountability Act-compliant prospective study was approved by our institutional review board. Thirty subjects (10 young asthmatic patients, 26 ± 6 years; 3 males, 7 females; 10 older asthmatic patients, 64 ± 6 years; 3 males, 7 females; 10 healthy controls) were enrolled...
February 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27643815/an-expanded-palette-of-xenon-129-nmr-biosensors
#16
Yanfei Wang, Ivan J Dmochowski
Molecular imaging holds considerable promise for elucidating biological processes in normal physiology as well as disease states, by determining the location and relative concentration of specific molecules of interest. Proton-based magnetic resonance imaging ((1)H MRI) is nonionizing and provides good spatial resolution for clinical imaging but lacks sensitivity for imaging low-abundance (i.e., submicromolar) molecular markers of disease or environments with low proton densities. To address these limitations, hyperpolarized (hp) (129)Xe NMR spectroscopy and MRI have emerged as attractive complementary methodologies...
October 18, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27526627/hyperpolarized-129-xe-mri-using-isobutene-as-a-new-quenching-gas
#17
Shota Hodono, Hirohiko Imai, Yukiko Yamauchi, Ayano Kawamura, Hironobu Matsumoto, Shintaro Okumura, Hideaki Fujiwara, Atsuomi Kimura
The use of a quenching gas, isobutene, with a low vapor pressure was investigated to enhance the utility of hyperpolarized (129) Xe (HP Xe) MRI. Xenon mixed with isobutene was hyperpolarized using a home-built apparatus for continuously producing HP Xe. The isobutene was then readily liquefied and separated almost totally by continuous condensation at about 173 K, because the vapor pressure of isobutene (0.247 kPa) is much lower than that of Xe (157 kPa). Finally, the neat Xe gas was continuously delivered to mice by spontaneous inhalation...
October 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27492388/feasibility-tolerability-and-safety-of-pediatric-hyperpolarized-129-xe-magnetic-resonance-imaging-in-healthy-volunteers-and-children-with-cystic-fibrosis
#18
Laura L Walkup, Robert P Thomen, Teckla G Akinyi, Erin Watters, Kai Ruppert, John P Clancy, Jason C Woods, Zackary I Cleveland
BACKGROUND: Hyperpolarized (129)Xe is a promising contrast agent for MRI of pediatric lung function, but its safety and tolerability in children have not been rigorously assessed. OBJECTIVE: To assess the feasibility, safety and tolerability of hyperpolarized (129)Xe gas as an inhaled contrast agent for pediatric pulmonary MRI in healthy control subjects and in children with cystic fibrosis. MATERIALS AND METHODS: Seventeen healthy control subjects (ages 6-15 years, 11 boys) and 11 children with cystic fibrosis (ages 8-16 years, 4 boys) underwent (129)Xe MRI, receiving up to three doses of (129)Xe gas prepared by either a commercially available or a homebuilt (129)Xe polarizer...
November 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27472552/detection-of-the-mild-emphysema-by-quantification-of-lung-respiratory-airways-with-hyperpolarized-xenon-diffusion-mri
#19
Weiwei Ruan, Jianping Zhong, Ke Wang, Guangyao Wu, Yeqing Han, Xianping Sun, Chaohui Ye, Xin Zhou
PURPOSE: To demonstrate the feasibility to quantify the lung respiratory airway in vivo with hyperpolarized xenon diffusion magnetic resonance imaging (MRI), which is able to detect mild emphysema in the rat model. MATERIALS AND METHODS: The lung respiratory airways were quantified in vivo using hyperpolarized xenon diffusion MRI (7T) with eight b values (5, 10, 15, 20, 25, 30, 35, 40 s/cm(2) ) in five control rats and five mild emphysematous rats, which were induced by elastase...
July 29, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27305488/a-genetically-encoded-%C3%AE-lactamase-reporter-for-ultrasensitive-129-xe-nmr-in-mammalian-cells
#20
Yanfei Wang, Benjamin W Roose, Eugene J Palovcak, Vincenzo Carnevale, Ivan J Dmochowski
Molecular imaging holds considerable promise for elucidating biological processes in normal physiology as well as disease states, but requires noninvasive methods for identifying analytes at sub-micromolar concentrations. Particularly useful are genetically encoded, single-protein reporters that harness the power of molecular biology to visualize specific molecular processes, but such reporters have been conspicuously lacking for in vivo magnetic resonance imaging (MRI). Herein, we report TEM-1 β-lactamase (bla) as a single-protein reporter for hyperpolarized (HP) (129) Xe NMR, with significant saturation contrast at 0...
July 25, 2016: Angewandte Chemie
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