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https://www.readbyqxmd.com/read/29449935/pleomorphic-liposarcoma-of-bone-a-rare-primary-malignant-bone-tumour
#1
G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Background: Liposarcoma is an extremely rare primary bone sarcoma. Case presentation: We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29448000/bone-marrow-derived-fibrocytes-promote-stem-cell-like-properties-of-lung-cancer-cells
#2
Atsuro Saijo, Hisatsugu Goto, Mayuri Nakano, Atsushi Mitsuhashi, Yoshinori Aono, Masaki Hanibuchi, Hirohisa Ogawa, Hisanori Uehara, Kazuya Kondo, Yasuhiko Nishioka
Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stromal cells regulate CSC-like properties by providing secreted factors or by physical contact. Fibrocytes are differentiated from bone marrow-derived CD14 + monocytes and have features of both macrophages and fibroblasts...
February 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29445158/ackr2-in-hematopoietic-precursors-as-a-checkpoint-of-neutrophil-release-and-anti-metastatic-activity
#3
Matteo Massara, Ornella Bonavita, Benedetta Savino, Nicoletta Caronni, Valeria Mollica Poeta, Marina Sironi, Elisa Setten, Camilla Recordati, Laura Crisafulli, Francesca Ficara, Alberto Mantovani, Massimo Locati, Raffaella Bonecchi
Atypical chemokine receptors (ACKRs) are regulators of leukocyte traffic, inflammation, and immunity. ACKR2 is a scavenger for most inflammatory CC chemokines and is a negative regulator of inflammation. Here we report that ACKR2 is expressed in hematopoietic precursors and downregulated during myeloid differentiation. Genetic inactivation of ACKR2 results in increased levels of inflammatory chemokine receptors and release from the bone marrow of neutrophils with increased anti-metastatic activity. In a model of NeuT-driven primary mammary carcinogenesis ACKR2 deficiency is associated with increased primary tumor growth and protection against metastasis...
February 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29445150/loss-of-ndrg2-in-liver-microenvironment-inhibits-cancer-liver-metastasis-by-regulating-tumor-associate-macrophages-polarization
#4
Mengyang Li, Xiaofeng Lai, Ying Zhao, Yuan Zhang, Minghui Li, Danxiu Li, Jing Kong, Yong Zhang, Pengyu Jing, Huichen Li, Hongyan Qin, Liangliang Shen, Libo Yao, Jipeng Li, Kefeng Dou, Jian Zhang
The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion of inhibitory factors, may be a potential therapeutic strategy for liver cancer metastasis treatment.We first cloned NDRG2 (N-myc downstream-regulated gene 2) and verified its tumor suppressor role in multiple solid tumors, including colorectal cancer and hepatocellular carcinoma...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29438361/a-first-in-human-phase-i-study-to-determine-the-maximum-tolerated-dose-of-the-oral-src-abl-inhibitor-azd0424
#5
Victoria K Woodcock, Sally Clive, Richard H Wilson, Vicky M Coyle, Michael R L Stratford, Lisa K Folkes, Richard Eastell, Claire Barton, Paul Jones, Shamim Kazmi-Stokes, Helen Turner, Sarah Halford, Adrian L Harris, Mark R Middleton
BACKGROUND: Src is involved in cancer invasion and metastasis. AZD0424, an oral inhibitor of Src and ABL1, has shown evidence of anti-tumour activity in pre-clinical studies. METHODS: A phase Ia, dose escalation study was performed to assess the safety of continuous oral dosing with AZD0424 in advanced solid tumours. Secondary objectives included investigation of AZD0424 pharmacokinetics, effect on Src activity using markers of bone turnover, and anti-tumour activity...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29436722/the-prognosis-of-different-distant-metastases-pattern-in-prostate-cancer-a-population-based-retrospective-study
#6
Jiafeng Shou, Qi Zhang, Shuai Wang, Dahong Zhang
BACKGROUND: The present of metastases is a poor prognostic factor in prostate cancer, but the prognostic impact of different distant metastases pattern is unclear. The aim of this study is to investigate the impact of different distant metastases pattern on the survival of patients with stage IV prostate cancer. METHODS: Data queried for this study include prostate cancer (2010-2014) from the Surveillance, Epidemiology, and End Results (SEER) program. Metastatic distribution information was provided for bone, brain, liver and lung...
February 13, 2018: Prostate
https://www.readbyqxmd.com/read/29435112/lncrna-malat1-regulates-smooth-muscle-cell-phenotype-switch-via-activation-of-autophagy
#7
Tie-Feng Song, Li-Wen Huang, Ying Yuan, Hui-Qin Wang, Hong-Peng He, Wen-Jian Ma, Li-Hong Huo, Hao Zhou, Nan Wang, Tong-Cun Zhang
Vascular smooth muscle cells (VSMCs), switching from a differentiated to a proliferative phenotype, contribute to various vascular diseases. However, the role of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 MALAT1 in the phenotype switching of VSMCs remains unclear. Here, we report that the knockdown of MALAT1 promotes the transformation of smooth muscle cells from a proliferative phenotype to a differentiated phenotype. MALAT1 knockdown inhibited cellular proliferation and migration, leading to significant cell cycle arrest in the G2 phase...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435019/nac1-promotes-the-migration-of-prostate-cancer-cells-and-participates-in-osteoclastogenesis-by-negatively-regulating-ifn%C3%AE
#8
Fang Chen, Yinghao Yin, Zhifeng Yan, Ke Cao, Kuangbiao Zhong
Nucleus accumbens-associated protein 1 (NAC1), a transcriptional co-regulator, is overexpressed in advanced prostate cancer. However, the NAC1-regulated transcriptome has not been completely explored. In the present study, the functional silencing of NAC1 blocked the migration of prostate cancer cells and suppress osteoclastogenesis. The present study also determined that NAC1 was overexpressed in the highly aggressive prostate cancer cell lines PC-3, DU-145 and LNCaP. NAC1 small interfering RNA treatment of DU-145 cells decreased cell migration, but interestingly had no significant effects on cell proliferation...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434993/prediction-of-decannulation-oral-intake-recovery-overall-survival-and-lung-metastasis-following-oral-malignant-tumor-resection-and-reconstruction
#9
Hidenori Suzuki, Ikuo Hyodo, Yasuhisa Hasegawa
The present study investigated whether tongue base and mandibular bone defects were associated with the rate of decannulation and oral intake recovery, and survival time, including overall and lung metastasis-free survival time, in patients that underwent oral malignant tumor (OMT) resection with reconstruction. A total of 105 patients that underwent OMT resection with laryngeal preservation and reconstruction were recruited. The extent of defects was classified according to Urken's classification. The rates of decannulation and oral intake recovery were assessed with the Kaplan-Meier method...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434937/prognostic-value-and-functional-role-of-rock2-in-pediatric-ewing-sarcoma
#10
Gabriela Maciel Vieira, Gabriela Molinari Roberto, Régia Caroline Lira, Edgard Eduard Engel, Luiz Gonzaga Tone, María Sol Brassesco
Ewing's sarcoma (EWS) is a highly aggressive bone cancer that affects children and adolescents. Despite advances in multimodal management, 5-year event-free survival rates for patients presenting with metastases at diagnosis remain at 25%. As key regulators of actin organization, the Rho-associated coiled-coil containing protein kinases, ROCK1 and ROCK2, have been associated with cancer dissemination and poorer prognosis. Recently, in vitro data indicating ROCK2 as a molecular target for the treatment of EWS has been presented...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434829/patellar-metastasis-from-primary-tumor
#11
Gang Li, Changxing Shan, Ran Sun, Song Liu, Song Chen, Mingzhi Song, Ming Lu
Although bone tumors are frequently located in the knee area, primary tumors of the patella are rare and patellar metastases are even rarer. Knee pain is the most common complaint of patients with patellar metastases. Owing to the low incidence of patellar metastases, misdiagnosis is not unusual. The present review analyzes ~44 cases of patellar metastases originating from distinct primary sites. Reports of malignant tumors of the lung and kidney metastasizing to the patella were more common than those of other patellar metastases...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434490/prognostic-factors-for-post-recurrence-survival-in-resected-pathological-stage-i-non-small-cell-lung-cancer
#12
Yasuaki Kubouchi, Yoshiteru Kidokoro, Takashi Ohno, Yohei Yurugi, Makoto Wakahara, Tomohiro Haruki, Hiroshige Nakamura
Background: Recurrence of lung cancer after surgical resection is a major obstacle in the cure and long-term survival of patients and has become the most common cause of death. However, prognostic factors and efficacy of therapy after recurrence remain controversial. We evaluated the prognostic factors of post recurrence survival (PRS) in patients of resected stage I non-small cell lung cancer (NSCLC). Methods: Of the 551 patients who underwent surgery for stage I NSCLC between 2005 and 2013, we reviewed 89 (16...
December 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/29432837/vitamin-k2-a-menaquinone-present-in-dairy-products-targets-castration-resistant-prostate-cancer-cell-line-by-activating-apoptosis-signaling
#13
Subramanyam Dasari, Angela Lincy Prem Antony Samy, Andre Kajdacsy-Balla, Maarten C Bosland, Gnanasekar Munirathinam
The aim of this study was to evaluate the therapeutic effects of vitamin K2 (VK2) on castration-resistant prostate cancer (CRPC) and its anti-cancer mechanisms in a pre-clinical study using a VCaP cell line (ATCC ® CRL-2876™) which was established from a vertebral bone metastasis from a patient with hormone refractory prostate cancer. Our data showed that VK2 significantly inhibited CRPC VCaP cell proliferation in a dosedependent manner at 48 h treatment in vitro. In addition, VK2 reduced the migration potential of VCaP cells and inhibited anchorage-independent growth of these cells...
February 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29430187/the-lncrna-pcat1-is-correlated-with-poor-prognosis-and-promotes-cell-proliferation-invasion-migration-and-emt-in-osteosarcoma
#14
Xuedong Zhang, Yakui Zhang, Yong Mao, Xinlong Ma
Introduction: Osteosarcoma is a malignant primary bone cancer and is lethal to children and adolescents. Recently, the dysregulation of long noncoding RNAs (lncRNAs) has been shown in various types of cancers. Aim: The present study aimed to examine the role of the lncRNA prostate cancer-associated transcript 1 (PCAT1) in osteosarcoma progression. Materials and methods: The expression levels of relevant genes in clinical samples and cell lines were determined by quantitative real-time polymerase chain reaction...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29430122/incidental-detection-of-perinephric-urinary-leak-on-bone-scintigraphy-in-a-patient-with-urinary-bladder-carcinoma
#15
Shelvin Kumar Vadi, Vaishnavi Dasagrandhi, Anish Bhattacharya, Shrawan Kumar Singh, Bhagwant Rai Mittal
A 71-year-old male patient with urothelial carcinoma of the bladder was referred for 99mTc-methylene diphosphonate bone scintigraphy to assess for skeletal metastasis. While the bone scan showed no abnormal skeletal uptake, tracer activity was detected in the extrarenal region of the left renal fossa on the planar image; single photon emission computed tomography-computed tomography (CT) demonstrated tracer pooling in the perirenal collection. In addition, the CT detected nontracer-avid parenchymal lung nodules and hypodense liver lesions consistent with metastatic disease...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29429426/do-patients-with-p16-positive-oropharyngeal-squamous-cell-carcinoma-get-more-bone-metastasis-than-p16-negative-patients
#16
A S Harris, R G Thomas, C D Passant
BACKGROUND: Oropharyngeal squamous cell carcinoma is thought to rarely metastasise to bone. This study hypothesised that in p16-positive disease there is a significant incidence of bony metastasis. METHODS: This was an ambispective cohort review. All patients with oropharyngeal squamous cell carcinoma diagnosed and treated at one centre were included. RESULTS: A total of 180 consecutive patients were identified over 5 years. Fifteen patients were excluded because of lack of p16 status, none of whom had bony metastasis...
February 12, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29429358/-change-of-paradigm-in-the-surgical-treatment-of-metastatic-diseases-of-the-bone-part-ii-treatment-of-spinal-metastases
#17
Áron Lazáry, Zsolt Szövérfi, Péter Pál Varga
The incidence of spinal metastases is constantly growing, but due to the advancements in oncologic treatment methods, the survival and the quality of life of the patients are persistently improving. Choosing the optimal treatment method is essential, and several factors should be considered: type of the primary tumor, segmental stability, the symptoms caused by the metastasis and the general condition of the patient. Using modern radiotherapeutic methods combined with minimally invasive surgical techniques (minimally invasive stabilization, separation surgery) in the majority of patients permits adequate local control with low complication rate...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29425304/associations-between-serum-bone-biomarkers-in-early-breast-cancer-and-development-of-bone-metastasis-results-from-the-azure-big01-04-trial
#18
Janet Brown, Emma Rathbone, Samantha Hinsley, Walter Gregory, Fatma Gossiel, Helen Marshall, Roger Burkinshaw, Helen Shulver, Hasina Thandar, Gianfilippo Bertelli, Keane Maccon, Angela Bowman, Andrew Hanby, Richard Bell, David Cameron, Robert Coleman
Background: Adjuvant therapies can prevent/delay bone metastasis development in breast cancer. We investigated whether serum bone turnover markers in early disease have clinical utility in identifying patients with a high risk of developing bone metastasis. Methods: Markers of bone formation (N-terminal propeptide of type-1 collagen [P1NP]) and bone resorption (C-telopeptide of type-1 collagen [CTX], pyridinoline cross-linked carboxy-terminal telopeptide of type-1 collagen [1-CTP]) were measured in baseline (pretreatment blood samples from 872 patients from a large randomized trial of adjuvant zoledronic acid (AZURE-ISRCTN79831382) in early breast cancer...
February 7, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29425276/giant-cell-tumor-of-bone-in-patients-55-years-and-older-a-study-of-34-patients
#19
Cory J Broehm, Carrie Y Inwards, Alyaa Al-Ibraheemi, Doris E Wenger, Sarah M Jenkins, Long Jin, Andre M Oliveira, Riyam T Zreik, Jodi M Carter, Jennifer M Boland, Karen J Fritchie
Objectives: Most giant cell tumors of bone (GCTs) occur in patients aged 20 to 40 years. We analyzed features of GCT in patients 55 years or older. Methods: GCTs were examined for fibrosis, matrix, cystic change, histiocytes, mitoses, and necrosis. Clinical/radiologic data were collected. Results: Thirty-four (5%) of 710 GCTs occurred in patients older than 55 years (14/20 male/female; 56-83 years) in long bones (n = 24), vertebrae (n = 6), pelvis (n = 3), and metacarpal (n = 1)...
February 7, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29424156/-particle-impaction-bone-graft-and-plate-internal-fixation-for-the-treatment-of-proximal-femoral-bone-tumor-or-tumor-lesion
#20
Hong-Tao Li, Yong-Zhi Yang, De-Bao Zhang, Gui-Shan Gu
OBJECTIVE: To evaluate the clinical feasibility of particle impaction bone graft and plate internal fixation for the treatment of proximal femoral bone tumors or tumor disease. METHODS: From January 2013 to January 2016 a total of 26 cases of the proximal femur bone tumors or tumor lesions, neither pathological fracture, were retrospectively analyzed, including 12 males and 14 females with an average age of 34.2 years old ranging from 8 to 62 years old. The pathologic result involved fibrous dysplasia in 11 cases, bone isolation bone cyst in 7 cases, giant cell tumors of bone in 3 cases, aneurysm sample bone cyst in 3 cases, non ossifying fibroma in 1 case, benign fibrous histiocytoma in 1 case...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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