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https://www.readbyqxmd.com/read/29927628/survival-outcomes-and-patterns-of-failure-after-d2-dissection-and-adjuvant-chemoradiotherapy-for-locally-advanced-gastric-cancer-a-retrospective-study
#1
Wang Yang, Ran Hu, Guichao Li, Menglong Zhou, Yan Wang, Lijun Shen, Liping Liang, Zhen Zhang
OBJECTIVE: The goal of the study was to analyze the incidence and patterns of failure in patients with gastric cancer who received D2 dissection and adjuvant chemoradiotherapy (CRT). METHODS: From January 2004 to October 2015, 324 patients with gastric cancer who underwent radical D2 resection followed by postoperative CRT were enrolled. Clinicopathological characteristics and patterns of failure were retrospectively reviewed to identify factors associated with survival and recurrence...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29927442/-extraskeletal-osteosarcoma-nosologocal-diversity-morphology-differential-diagnosis-and-features-of-metastasis
#2
N V Vasiliev, S V Poletaeva, S A Maltseva, A А Zheravin, Yu I Tyukalov, P G Baidala
Extraskeletal osteosarcoma is a rare malignant tumor with histologic similarities to primary bone osteosarcoma. However, there are distinct differences in epidemiology, imaging features, biological characteristics, prognosis, and management compared with osteogenic osteosarcoma. Extraskeletal osteosarcoma is usually characterized as high-grade neoplasm with clinically aggressive behavior, poor prognosis, frequent recurrence/lymphogenic metastatsis, and resistence to chemotherapy. A noteworthy feature of extraskeletal osteosarcoma is the fact that almost all existing biological phenomena described in mesenchymal oncopathology (except primary-multiple lesions) are present in this tumor, namely: secondary malignancy, association with syndromes, partial spontaneous regression of the tumor, dedifferentiation, bone invasion, biphasic pathology...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29926007/diagnostic-performance-of-11c-choline-pet-ct-and-fdg-pet-ct-in-prostate-cancer
#3
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Kaoru Kobayashi, Masayuki Fujiwara, Norihiko Kamikonya, Kazuhito Fukushima, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Koichiro Yamakado
We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55...
June 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29923984/clinicopathological-and-prognostic-significance-of-pd-l1-expression-in-sarcoma-a-systematic-review-and-meta-analysis
#4
Chuanxi Zheng, Wei You, Peng Wan, Xiaochun Jiang, Jinquan Chen, Yuchen Zheng, Wei Li, Jifeng Tan, Shiquan Zhang
Programmed cell death-ligands 1 (PD-L1) is a key immune checkpoint protein and a promising therapeutic target for malignancy tumor immunotherapy. The prognostic value of PD-L1 in patients with bone and soft tissue sarcoma remains controversial. Therefore, this meta-analysis is conducted to evaluate the associations of PD-L1 expression with overall survival (OS), progression-free survival (PFS), and clinicopathological characteristics of sarcomaA comprehensive literature search of PubMed, Web of Science, Embase, and Cochrane Library was conducted for relevant studies...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923514/whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-18-f-fdg-pet-ct-for-staging-locally-advanced-breast-cancer-a-prospective-study-from-a-tertiary-cancer-centre-in-south-india
#5
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29923200/egfl7-master-regulator-of-cancer-pathogenesis-angiogenesis-and-an-emerging-mediator-of-bone-homeostasis
#6
REVIEW
Guoju Hong, Vincent Kuek, Jiaxi Shi, Lin Zhou, Xiaorui Han, Wei He, Jennifer Tickner, Heng Qiu, Qiushi Wei, Jiake Xu
Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion...
June 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29921292/exploring-the-key-genes-and-pathways-of-side-population-cells-in-human-osteosarcoma-using-gene-expression-array-analysis
#7
Yi-Ming Ren, Yuan-Hui Duan, Yun-Bo Sun, Tao Yang, Wen-Jun Zhao, Dong-Liang Zhang, Zheng-Wei Tian, Meng-Qiang Tian
BACKGROUND: Human osteosarcoma (OS) is one of the most common primary bone sarcoma, because of early metastasis and few treatment strategies. It has been reported that the tumorigenicity and self-renewal capacity of side population (SP) cells play roles in human OS via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) that regulated between the SP cells and the non-SP cells from primary human OS and identify their functions and molecular pathways associated with OS...
June 19, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29921200/different-targeting-strategies-for-treating-breast-cancer-bone-metastases
#8
Iram Irshad, Pegah Varamini
BACKGROUND: Breast cancer is the most frequently diagnosed malignancy in women worldwide. Breast cancer tends to metastasize to bone. Around 70% of the breast cancer patients eventually develop bone metastasis. After the bone invasion, metastatic cells disrupt the balance between osteoblastic and osteoclastic activities, leading to skeletal complications, characterized by pain and pathological fractures and hence worsening the patient's quality of life. Once tumor invades the bone, it is hard to treat it with, the so-far available treatments options (e...
June 19, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29920292/novel-tumor-necrosis-factor-%C3%AE-induced-protein-eight-tnfaip8-tipe-family-functions-and-downstream-targets-involved-in-cancer-progression
#9
Ganesan Padmavathi, Kishore Banik, Javadi Monisha, Devivasha Bordoloi, Shabnam Bano, Frank Arfuso, Gautam Sethi, Fan Lu, Ajaikumar B Kunnumakkara
The tumor necrosis factor (TNF)-α- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, inflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancreas, prostate, and thyroid gland...
June 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29917166/sb225002-inhibits-prostate-cancer-invasion-and-attenuates-the-expression-of-bsp-opn-and-mmp%C3%A2-2
#10
Meng Xu, Huamao Jaing, Haiguang Wang, Jiajie Liu, Baohao Liu, Zhongqiang Guo
The mechanisms of malignant cell metastasis to secondary sites are complex and multifactorial. Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. SIBLINGs promote malignant cell invasion and metastasis by enhancing matrix metalloproteinase 2 (MMP‑2) and MMP‑9 expression. Moreover, BSP and OPN can combine with integrin, which is located on the tumor cell surface, to further promote the malignant behavior of tumor cells...
June 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29916127/the-c-terminal-intact-forms-of-periostin-iptn-are-surrogate-markers-for-osteolytic-lesions-in-experimental-breast-cancer-bone-metastasis
#11
Evelyne Gineyts, Nicolas Bonnet, Cindy Bertholon, Marjorie Millet, Aurélie Pagnon-Minot, Olivier Borel, Sandra Geraci, Edith Bonnelye, Martine Croset, Ali Suhail, Cristina Truica, Nicholas Lamparella, Kim Leitzel, Daniel Hartmann, Roland Chapurlat, Allan Lipton, Patrick Garnero, Serge Ferrari, Philippe Clézardin, Jean-Charles Rousseau
Periostin is an extracellular matrix protein that actively contributes to tumor progression and metastasis. Here, we hypothesized that it could be a marker of bone metastasis formation. To address this question, we used two polyclonal antibodies directed against the whole molecule or its C-terminal domain to explore the expression of intact and truncated forms of periostin in the serum and tissues (lung, heart, bone) of wild-type and periostin-deficient mice. In normal bones, periostin was expressed in the periosteum and specific periostin proteolytic fragments were found in bones, but not in soft tissues...
June 18, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29913031/four-year-survival-of-a-patient-with-spinal-metastatic-acinic-cell-carcinoma-after-a-total-en-bloc-spondylectomy-and-reconstruction-with-a-frozen-tumor-bearing-bone-graft
#12
Apiruk Sangsin, Hideki Murakami, Takaki Shimizu, Satoshi Kato, Hiroyuki Tsuchiya
Acinic cell carcinoma metastasizing to the spine is extremely rare. The authors present a case of acinic cell carcinoma of the parotid gland with subsequent lung and spinal metastases, treated with en bloc spondylectomy. A 41-year-old man presented with a left parotid mass. After being diagnosed with acinic cell carcinoma, he underwent a total parotidectomy. Imaging studies revealed a metastatic osteoblastic lesion in the T4 vertebral body and multiple lung metastases. Total en bloc spondylectomy and reconstruction with a frozen tumor-bearing bone graft were performed to treat the T4 metastasis...
June 18, 2018: Orthopedics
https://www.readbyqxmd.com/read/29909612/clinical-characteristics-of-temporal-bone-metastases
#13
Kunho Song, Ki-Wan Park, Jae-Hyung Heo, Ik-Chan Song, Yong-Ho Park, Jin Woong Choi
Objectives: The purposes of this study were to evaluate the clinical characteristics of temporal bone metastasis (TBM) and to determine whether the characteristics differed according to primary malignancy. Methods: We retrospectively analyzed data on 20 patients diagnosed with TBM between January 2000 and January 2017. Demographics, the period from diagnosis of primary malignancy to TBM diagnosis, the period from TBM diagnosis to death, the type and staging of primary malignancy, otologic manifestations, and TBM sites were assessed...
June 19, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29909077/connective-tissue-growth-factor-stimulates-osteosarcoma-cell-migration-and-induces-osteosarcoma-metastasis-by-upregulating-vcam-1-expression
#14
Chun-Han Hou, Rong-Sen Yang, Ya-Ting Tsao
Osteosarcoma is the most common bone malignancy that occurs in the young population. After osteosarcoma cells metastasize to the lung, prognosis is very poor owing to difficulties in early diagnosis and effective treatment. Recently, connective tissue growth factor (CTGF) was reported to be a critical contributor to osteosarcoma metastasis. However, the detailed mechanism associated with CTGF-directed migration in bone neoplasms is still mostly unknown. Through the in vivo and in vitro examination of osteosarcoma cells, this study suggests that VCAM-1 up-regulation and increased osteosarcoma cell migration are involved in this process...
June 14, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29908016/peroxiredoxin-1-prdx1-suppresses-progressions-and-metastasis-of-osteosarcoma-and-fibrosarcoma-of-bone
#15
Yongxiang Wang, Mingfa Liu, Peng Yang, Hao Peng
BACKGROUND Osteosarcoma and fibrosarcoma are malignant tumors with poor prognosis. Peroxiredoxin 1 (PRDX1) is considered to prevent tumors in many malignances. However, few studies have focused on the functions of PRDX1 in osteosarcoma and fibrosarcoma. MATERIAL AND METHODS PRDX1 mRNA in tumors and adjacent tissues of 32 osteosarcoma patients and 16 fibrosarcoma patients was extracted and measured. Proliferation and invasion of MG63 and HT1080 cell lines after silencing or overexpressing PRDX1 were used to detect the role of PRDX1 in metastasis of osteosarcoma and fibrosarcoma...
June 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29907594/repositioning-dopamine-d2-receptor-agonist-bromocriptine-to-enhance-docetaxel-chemotherapy-and-treat-bone-metastatic-prostate-cancer
#16
Yang Yang, Kenza Mamouni, Xin Li, Yanhua Chen, Sravan Kavuri, Yuhong Du, Haian Fu, Omer Kucuk, Daqing Wu
Docetaxel resistance remains a major obstacle in the treatment of prostate cancer (PCa) bone metastasis. In this study, we demonstrate that the dopamine D2 receptor (DRD2) agonist bromocriptine effectively enhances docetaxel efficacy and suppresses skeletal growth of PCa in preclinical models. DRD2 is ubiquitously expressed in PCa cell lines, and DRD2 is significantly reduced in PCa tissues with high Gleason score. Bromocriptine has weak to moderate cytotoxicity in PCa cells, but effectively induces cell cycle arrest...
June 15, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29905536/microrna-506-3p-inhibits-osteosarcoma-cell-proliferation-and-metastasis-by-suppressing-rab3d-expression
#17
Wang Jiashi, Qiu Chuang, Zhang Zhenjun, Wang Guangbin, Li Bin, He Ming
Osteosarcoma is an aggressive bone tumor primarily affecting children and adolescents. Its cause is not yet fully understood, and there is an urgent need for more effective treatment. In the present study we identified several miRNAs whose expression is altered in osteosarcoma compared to adjacent normal tissue. Moreover, expression levels of one of those miRNAs, miR-506-3p, correlated negatively with expression of RAB3D (a Ras-related protein). Suppression of miR-506-3p in osteosarcoma led to increased expression of RAB3D, which in turn led to increased CDK4 (cyclin-dependent kinase 4) and MMP9 (matrix metalloprotein 9) activities...
June 10, 2018: Aging
https://www.readbyqxmd.com/read/29904494/humeral-metastasis-of-sacrococcygeal-chordoma-detected-by-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-a-case-report
#18
Futao Cui, Minggang Su, Han Zhang, Rong Tian
Chordomas are rare, slow-growing, locally aggressive bone tumors arising from embryonic remnants of the notochord. Distant metastases most commonly involve the lung, liver, axial skeleton, skin, and lymph nodes. Humeral metastases are extremely rare. We report the case of a recurrent chordoma with humeral metastasis, complicated with pathologic fracture. Fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography revealed multiple hypermetabolic skeletal lesions, corresponding to the symptoms...
April 2018: Radiology case reports
https://www.readbyqxmd.com/read/29904105/an-interdisciplinary-consensus-on-the-management-of-bone-metastases-from-renal-cell-carcinoma
#19
REVIEW
Viktor Grünwald, Berit Eberhardt, Axel Bex, Anne Flörcken, Thomas Gauler, Thorsten Derlin, Martin Panzica, Hans Roland Dürr, Knut Achim Grötz, Rachel H Giles, Christian von Falck, Anno Graser, Alexander Muacevic, Michael Staehler
Bone is a major site of haematogenous tumour cell spread in renal cell carcinoma (RCC), and most patients with RCC will develop painful and functionally disabling bone metastases at advanced disease stages. The prognosis of these patients is generally poor and the treatment is, therefore, aimed at palliation. However, RCC-associated bone metastases can be curable in select patients. Current data support a multimodal management strategy that includes wide resection of lesions, radiotherapy, systemic therapy, and other local treatment options, which can improve quality of life and survival...
June 14, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29903571/role-of-cxcl12-and-cxcr4-in-the-pathogenesis-of-hematological-malignancies
#20
Amnon Peled, Shiri Klein, Katia Beider, Jan A Burger, Michal Abraham
The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in many type of tumors including lymphoma, leukemia, glioma, and prostate, breast, colorectal, renal, and hepatocellular carcinomas...
September 2018: Cytokine
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