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https://www.readbyqxmd.com/read/26850410/factors-associated-with-the-failure-of-first-and-second-line-antiretroviral-therapies-therapy-a-case-control-study-in-cambodian-hiv-1-infected-children
#1
Hubert Barennes, Kang Virak, François Rouet, Yves Buisson, Michel Strobel, Ung Vibol
BACKGROUND: Little is known about the efficacy of first and and second-line antiretroviral therapies (ART) for HIV-1 infected children in resource limited Southeast Asian settings. Previous studies have shown that orphans are at a higher risk for virological failure (VF) in Cambodia. Consequently most of them required transfer to second-line ART. We assessed the factors associated with VF among HIV-1 infected children who were either under first-line (mostly 3TC + D4T + NVP) or under second-line (mostly ABC + DDI + LPV) therapies at a referral hospital in Cambodia...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/26807589/a-single-nucleotide-polymorphism-in-abcc4-is-associated-with-tenofovir-related-beta2-microglobulinuria-in-thai-patients-with-hiv-1-infection
#2
Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Wisit Prasithsirikul, Emi E Nakayama, Tatsuo Shioda, Chariya Sangsajja
BACKGROUND: In Thailand, the combined generic anti-retroviral drug stavudine/lamivudine/nevirapine (d4T/3TC/NVP) has been used to treat human immunodeficiency virus (HIV)-infected individuals since 2001. Due to relatively frequent adverse effects, d4T gradually has been replaced with tenofovir disoproxil fumarate (TDF). Although the frequency of adverse drug effects with TDF is lower than that with d4T, TDF is known to induce kidney dysfunction, especially in the proximal tubules. It has been reported that renal tubular transporters, including members of the multi-drug resistant (MDR) protein family, are implicated in tenofovir extrusion and may, therefore, confer susceptibility to TDF-induced kidney tubular dysfunction (KTD)...
2016: PloS One
https://www.readbyqxmd.com/read/26643107/inverse-association-between-microrna-124a-and-abcc4-in-hepg2-cells-treated-with-antiretroviral-drugs
#3
Savania Nagiah, Alisa Phulukdaree, Anil Chuturgoon
The ATP-binding cassette (ABC) super-family of drug transporters regulates efflux of xenobiotic compounds. The subfamily, multi-drug resistance proteins (MRPs) transports cyclic nucleotides and xenobiotics. Epigenetic modulation of drug transporters is scarcely described. The regulatory role of microRNA (miR)-124a on drug transporter gene ABCC4 was only recently reported. Our study investigated the differential regulation of miR-124a by nucleoside reverse transcriptase inhibitors (NRTIs): Zidovudine (AZT), Stavudine (d4T) and Tenofovir (TFV); at 24 h and 120 h treatments in HepG2 cells...
September 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/26564627/-effect-of-treatment-and-hiv-drug-resistance-of-81-cases-of-hcv-hiv-co-infected-individuals-who-had-received-aids-second-line-antiretroviral-treatment-in-henan-province
#4
Dingyong Sun, Jia Liu, Qi Wang, Wenjie Yang, Yanchao Yue, Zhiyong Guo, Shimei Yang, Qian Zhu, Zhe Wang
OBJECTIVE: To understand the one-year effect of HCV/HIV co-infected patients who had received AIDS second-line antiretroviral treatment after failure virologically, on the first-line therapy. METHODS: HCV and HIV antibody positive patients who had experienced virological failure but received at least one-year AIDS first-line treatment, were recruited from May to October 2012 in Xincai, Queshan and Weishi of Henan province. 6-months and 12-months follow-up programs were carried out after the regimen had been changed to AIDS second-line antiretroviral treatment, CD4⁺ T lymphocyte count, HIV-1 virus load and HIV-1 drug resistance were performed...
June 2015: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/26537918/effect-of-abacavir-on-sustained-virologic-response-to-hcv-treatment-in-hiv-hcv-co-infected-patients-cohere-in-eurocoord
#5
Colette Smit, Joop Arends, Lars Peters, Antonella d'Arminio Montforte, Francois Dabis, Robert Zangerle, George Daikos, Christina Mussini, Josep Mallolas, Stephane de Wit, Annelies Zinkernagel, Jaime Cosin, Genevieve Chene, Dorthe Raben, Jürgen Rockstroh
BACKGROUND: Contradicting results on the effect of abacavir (ABC) on hepatitis C virus (HCV) treatment responses in HIV/HCV co-infected patients have been reported. We evaluated the influence of ABC on the response to pegylated interferon (pegIFN) and ribavirin (RBV)-containing HCV treatment in HIV/HCV co-infected patients in a large European cohort collaboration, including data from different European countries. METHODS: HIV/HCV co-infected patients were included if they were aged ≥16 years, received pegIFN alfa-2a or 2b and RBV combination treatment and were enrolled in the COHERE cohort collaboration...
November 4, 2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/24854905/-analysis-of-hiv-genotypic-drug-resistance-among-pediatric-hiv-aids-cases-with-virological-failure-after-free-antiretroviral-therapy-in-yunnan-province
#6
Min Zhong, Shaomin Yang, Bihui Yang, Jiafa Liu, Jianjian Li, Jincheng Lou, Huiqin Li
OBJECTIVE: To assess the prevalence and the characteristics of HIV-1 drug-resistance in pediatric HIV/AIDS cases with virological failure after free antiretroviral therapy in Yunnan Province. METHODS: The data of clinical test and laboratory detection about free antiretroviral therapy in pediatric HIV/AIDS cases from 2005 to 2012 were collected. Then the detection of HIV genotypical drug resistance was performed for the plasmas samples whose viral load were over 1 000 copies/ml after the duration of antiretroviral therapy beyond 6 months...
April 1, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/24507237/-evaluation-of-the-consistency-of-three-methods-for-testing-hiv-1-genotype-drug-resistance
#7
COMPARATIVE STUDY
Jing Li, Yan Jiang, Chao Lü, Jing Wang, Jun Yao
OBJECTIVE: To compare the concordance in predicting genotype HIV-1 drug resistance between In-house method and TRUGENE(TM) or ViroSeq(TM) method. METHODS: 25 international proficiency testing (PT) samples received from 2009 to 2013 were detected by three methods, then pairwise comparison results was analyzed to validate their concordance on drug resistance mutation and drug resistance report. To further confirm the results, another 15 serum specimens were detected by In-house and TRUGENE(TM) methods, then compared their results concordance...
November 2013: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/24378944/virologic-response-in-children-treated-with-abacavir-compared-with-stavudine-based-antiretroviral-treatment-a-south-african-multi-cohort-analysis
#8
Karl-Günter Technau, Michael Schomaker, Louise Kuhn, Harry Moultrie, Ashraf Coovadia, Brian Eley, Helena Rabie, Robin Wood, Vivian Cox, Luisa Salazar Vizcaya, Evans Muchiri, Mary-Ann Davies
BACKGROUND: Initiation criteria and pediatric antiretroviral treatment regimens have changed over the past few years in South Africa. We reported worse early virological outcomes associated with the use of abacavir (ABC)-based regimens at 1 large site: here, we expand this analysis to multiple sites in the IeDEA-Southern Africa collaboration. METHODS: Data for 9543 antiretroviral treatment-naïve children <16 years at treatment initiation started on either stavudine/lamivudine (d4T/3TC) or ABC/3TC with efavirenz (EFV) or ritonavir-boosted lopinavir (LPV/r) treated at 6 clinics in Johannesburg and Cape Town, South Africa, were analyzed with χ tests and logistic regression to evaluate viral suppression at 6 and 12 months...
June 2014: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/23860481/poor-early-virologic-performance-and-durability-of-abacavir-based-first-line-regimens-for-hiv-infected-children
#9
Karl-Günter Technau, Erica Lazarus, Louise Kuhn, Elaine J Abrams, Gillian Sorour, Renate Strehlau, Gary Reubenson, Mary-Ann Davies, Ashraf Coovadia
BACKGROUND: Concerns about stavudine (d4T) toxicity have led to increased use of abacavir (ABC) in first-line pediatric antiretroviral treatment (ART) regimens. Field experience with ABC in ART-naïve children is limited. METHODS: Deidentified demographic, clinical and laboratory data on HIV-infected children initiating ART between 2004 and 2011 in a large pediatric HIV treatment program in Johannesburg, South Africa, were used to compare viral suppression at 6 and 12 months by initial treatment regimen, time to suppression (<400 copies/mL) and rebound (>1000 copies/mL after initial suppression)...
August 2013: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/23840622/trends-in-genotypic-hiv-1-antiretroviral-resistance-between-2006-and-2012-in-south-african-patients-receiving-first-and-second-line-antiretroviral-treatment-regimens
#10
Gert U Van Zyl, Tommy F Liu, Mathilda Claassen, Susan Engelbrecht, Tulio de Oliveira, Wolfgang Preiser, Natasha T Wood, Simon Travers, Robert W Shafer
OBJECTIVES: South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted lopinavir (LPV/r)-containing therapy...
2013: PloS One
https://www.readbyqxmd.com/read/23614033/the-nrtis-lamivudine-stavudine-and-zidovudine-have-reduced-hiv-1-inhibitory-activity-in-astrocytes
#11
Lachlan R Gray, Gilda Tachedjian, Anne M Ellett, Michael J Roche, Wan-Jung Cheng, Gilles J Guillemin, Bruce J Brew, Stuart G Turville, Steve L Wesselingh, Paul R Gorry, Melissa J Churchill
HIV-1 establishes infection in astrocytes and macroage-lineage cells of the central nervous system (CNS). Certain antiretroviral drugs (ARVs) can penetrate the CNS, and are therefore often used in neurologically active combined antiretroviral therapy (Neuro-cART) regimens, but their relative activity in the different susceptible CNS cell populations is unknown. Here, we determined the HIV-1 inhibitory activity of CNS-penetrating ARVs in astrocytes and macrophage-lineage cells. Primary human fetal astrocytes (PFA) and the SVG human astrocyte cell line were used as in vitro models for astrocyte infection, and monocyte-derived macrophages (MDM) were used as an in vitro model for infection of macrophage-lineage cells...
2013: PloS One
https://www.readbyqxmd.com/read/23435299/vitamin-d-attenuates-nucleoside-reverse-transcriptase-inhibitor-induced-human-skeletal-muscle-mitochondria-dna-depletion
#12
Grant R Campbell, Zachary T Pallack, Stephen A Spector
OBJECTIVE: To evaluate the impact of the active metabolite of vitamin D, 1α,25-dihydroxycholecalciferol (1,25D3), on nucleoside reverse transcriptase inhibitor (NRTI) induced mitochondrial DNA (mtDNA) depletion in human skeletal muscle myoblasts and myotubes. DESIGN: mtDNA was quantified in human skeletal muscle myoblasts and myotubes following 1,25D3 and NRTI treatment using real-time PCR. METHODS: Human skeletal muscle myoblasts and myotubes were treated with didanosine (ddI), stavudine (d4T), zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) alone or in combination either in the presence or absence of 1,25D3 for 5 days...
June 1, 2013: AIDS
https://www.readbyqxmd.com/read/23225268/absence-of-liver-steatosis-in-hiv-hcv-co-infected-patients-receiving-regimens-containing-tenofovir-or-abacavir
#13
V Borghi, L Bisi, L Manzini, A Cossarizza, C Mussini
BACKGROUND: In human immunodeficiency virus-hepatitis C virus (HIV-HCV) co-infected patients, steatosis has been independently associated with a number of antiretroviral drugs, including stavudine, especially in patients with non-3 HCV genotypes. We retrospectively investigated the presence of steatosis among HIV-HCV co-infected and HCV mono-infected patients, and the role of tenofovir disoproxil fumarate (TDF) or abacavir (ABC) in determining hepatic steatosis. METHODS: Liver steatosis was retrospectively evaluated in all consecutive biopsies performed in the period 2000-2008 in HCV mono-infected and HIV-HCV co-infected patients...
April 2013: Infection
https://www.readbyqxmd.com/read/23171153/impact-of-baseline-hiv-1-rna-levels-on-initial-highly-active-antiretroviral-therapy-outcome-a-meta-analysis-of-12-370-patients-in-21-clinical-trials
#14
REVIEW
C Stephan, A Hill, W Sawyer, Y van Delft, C Moecklinghoff
BACKGROUND: Individual randomized trials of first-line antiretroviral treatment do not consistently show an association between higher baseline HIV-1 RNA and lower efficacy. METHODS: A MEDLINE search identified 21 HIV clinical trials with published analyses of antiretroviral efficacy by baseline HIV-1 RNA, using a standardized efficacy endpoint of HIV-1 RNA suppression <50 copies/mL at week 48. RESULTS: Among 21 clinical trials identified, eight evaluated only nonnucleoside reverse transcriptase inhibitor (NNRTI)-based combinations, eight evaluated only protease inhibitor-based regimens and five compared different treatment classes...
May 2013: HIV Medicine
https://www.readbyqxmd.com/read/22160938/emerging-trends-of-drug-resistant-hiv-1-among-drug-treated-patients-in-former-blood-donors-in-hubei-china-a-three-year-surveillance-from-2004-to-2006
#15
Jian Gong, Xiao-Qiong Wang, Xiao Tong, Xi-Hui Shen, Rong-Ge Yang
This study aimed to evaluate emerging trends of drug resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) among 290 former blood donor HIV-1 infected patients in Hubei, China, from 2004 to 2006, all of whom had received anti-HIV-1 therapy. The presence of NRTI- and NNRTI-associated mutations were established by sequencing; genotypic and predicted phenotypic drug resistance were evaluated using HIVdb Program version 5.0.1 (http://hivdb...
December 2011: Virologica Sinica
https://www.readbyqxmd.com/read/21972264/reverse-transcriptase-genotypes-in-pediatric-patients-failing-initial-antiretroviral-therapy-in-gaborone-botswana
#16
Michael Tolle, Leigh Howard, Brianna Kirk, Andres Gomila, Heidi Schwarzwald, Gabriel Anabwani
BACKGROUND: Limited data are available on patterns of resistance mutations in pediatric patients in southern Africa, where HIV-1 subtype C (HIV-1C) predominates. METHODS: Retrospective chart review of pediatric patients. Nucleoside reverse transcriptase inhibitor (NRTI)- and nonnucleoside reverse transcriptase inhibitor (NNRTI)-associated resistance mutations quantified from population-based sequencing genotypic resistance assay results taken at time of first-line antiretroviral therapy (ART) failure (first-line ART = stavudine [d4T] or zidovudine [ZDV] + lamivudine [3TC] + nevirapine [NVP] or efavirenz [EFV])...
July 2012: Journal of the International Association of Physicians in AIDS Care: JIAPAC
https://www.readbyqxmd.com/read/21235431/from-old-to-new-nucleoside-reverse-transcriptase-inhibitors-changes-in-body-fat-composition-metabolic-parameters-and-mitochondrial-toxicity-after-the-switch-from-thymidine-analogs-to-tenofovir-or-abacavir
#17
REVIEW
Adrian Curran, Esteban Ribera
INTRODUCTION: Thymidine analogs zidovudine (AZT) and stavudine (d4T) have been widely used because of their antiviral activity against HIV, but at the expense of high toxicity, mainly related to mitochondrial damage. Many studies have been performed replacing AZT or d4T with newer nucleoside analogs reverse transcriptase inhibitors (NRTIs) with less toxicity, such as tenofovir (TDF) or abacavir (ABC), maintaining virological efficacy. AREAS COVERED: Relevant literature was identified using a PubMed search of articles published up to June 2010...
May 2011: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/21126959/comparison-of-antiviral-activity-of-regimens-containing-nucleos-t-ide-nuc-pairs-in-hiv-infected-patients-initiating-rescue-therapy-the-nucrest-study
#18
MULTICENTER STUDY
J A Pérez-Molina, O Serrano, A Milinkovic, P Domingo, A Currán, H Knobel, G Gaspar, A Rodrigo, M J Jiménez-Expósito, B Hernández-Novoa, S Moreno, The NUCREST Study
BACKGROUND: recycling nucleos(t)ides (NUCs) is useful in regions where new antiretrovirals are not available. This study compares the effectiveness of NUC-containing regimens as rescue therapy in routine care. METHODS: retrospective, multicentre cohort study (January 2001 to June 2006) of patients with ≥ 1 virological failure who started therapy with 2 NUCs and 1 non-nucleoside reverse transcriptase inhibitor (NNRTI) or a protease inhibitor (PI). The primary endpoint was the rate of treatment response at 6 months (intention-to-treat [ITT] analysis)...
September 2010: HIV Clinical Trials
https://www.readbyqxmd.com/read/21078952/determinants-of-individual-variation-in-intracellular-accumulation-of-anti-hiv-nucleoside-analog-metabolites
#19
Elijah Paintsil, Ginger E Dutschman, Rong Hu, Susan P Grill, Chuan-Jen Wang, Wing Lam, Fang-Yong Li, Musie Ghebremichael, Veronika Northrup, Yung-Chi Cheng
Individual variation in response to antiretroviral therapy is well-known, but it is not clear if demographic characteristics such as gender, age, and ethnicity are responsible for the variation. To optimize anti-HIV therapy and guide antiretroviral drug discovery, determinants that cause variable responses to therapy need to be evaluated. We investigated the determinants of intracellular concentrations of nucleoside analogs using peripheral blood mononuclear cells from 40 healthy donors. We observed individual differences in the concentrations of the intracellular nucleoside analogs; the mean concentrations of the triphosphate metabolite of ethynylstavudine (4'-Ed4T), zidovudine (AZT), and lamivudine (3TC) were 0...
February 2011: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/20718629/genotypic-and-phenotypic-cross-drug-resistance-of-harboring-drug-resistant-hiv-type-1-subtype-b-strains-from-former-blood-donors-in-central-chinese-provinces
#20
Liying Ma, Jianghong Huang, Hui Xing, Lin Yuan, Xiaoling Yu, Jianping Sun, Yang Huang, Shuiling Qu, Yi Feng, Linjie Liao, Shuwen Liu, Yiming Shao
The objective of this study was to assess the patterns of genotypic and phenotypic resistance in a population of blood donor patients infected with HIV-1 subtype B' (Thai B', a clade of HIV-1 B) from central China, previously treated and harboring NRTI and NNRTI resistance mutations, with the purpose of designing effective therapeutic regimens. The HIV-1 pol genes from 65 patients were sequenced and estimated for drug resistance while the viruses isolated from the patients were used to analyze the phenotype based on the TZM-bl cell line...
September 2010: AIDS Research and Human Retroviruses
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