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https://www.readbyqxmd.com/read/28646803/effects-of-balneotherapy-on-serum-levels-of-shingosine-1-phosphate-in-patients-with-osteoarthritis
#1
Esra Aycan Ustyol, Fatih Karaarslan, Seldag Bekpinar, Kagan Ozkuk, Nergis Erdogan
Context • Balneotherapy is one of the most commonly used nonpharmacological interventions for osteoarthritis (OA), but its mechanism of action in relieving pain and stiffness and in improving physical function is not well understood. Studies have found that therapy provokes a series of neuroendocrinal reactions with anti-inflammatory and analgesic effects. Sphingosine-1-phosphate (S1P), a bioactive lipid, has been implicated as an important mediator in the maintenance of physiological processes (eg, vascular barrier integrity) and in pathophysiologic processes such as inflammatory conditions...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646725/eculizumab-decreases-the-procoagulant-activity-of-extracellular-vesicles-in-paroxysmal-nocturnal-hemoglobinuria-a-pilot-prospective-longitudinal-clinical-study
#2
Adeline Wannez, Bérangère Devalet, Céline Bouvy, Julie Laloy, Benoit Bihin, Bernard Chatelain, Christian Chatelain, Jean-Michel Dogné, François Mullier
INTRODUCTION: Paroxysmal nocturnal hemoglobinuria (PNH) is a disease characterized by the susceptibility of blood cells to attack by the complement system, inducing extracellular vesicle (EV) production. Thromboembolism is the leading cause of death in this condition. Eculizumab, a humanized monoclonal antibody which inhibits the C5 protein of the complement, reduces the thrombotic risk in PNH. MATERIALS AND METHOD: We conducted a pilot, prospective, open-label, longitudinal clinical study with six PNH patients treated with eculizumab...
June 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28646709/association-between-father-involvement-and-attitudes-in-early-child-rearing-and-depressive-symptoms-in-the-pre-adolescent-period-in-a-uk-birth-cohort
#3
Charles Opondo, Maggie Redshaw, Maria A Quigley
BACKGROUND: Much of the research on parenting and its influence on child development has emphasised the mother's role. However, increasing evidence highlights the important role of fathers in the development, health and well-being of their children. We sought to explore the association between paternal involvement in early child-rearing and depressive symptoms in 9 and 11 year-old children. METHODS: We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort recruited in the southwest of England...
June 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28646688/solar-radiation-and-out-of-hospital-cardiac-arrest-in-japan
#4
Daisuke Onozuka, Akihito Hagihara
BACKGROUND: Although several studies have estimated the effects of temperature on mortality and morbidity, little is known regarding the burden of out-of-hospital cardiac arrest (OHCA) attributable to solar radiation. METHODS: We obtained data for all cases of OHCA and meteorological data reported between 2011 and 2014 in 3 Japanese prefectures: Hokkaido, Ibaraki, and Fukuoka. We first examined the relationship between daily solar radiation and OHCA risk for each prefecture using time-varying distributed lag non-linear models and then pooled the results in a multivariate random-effects meta-analysis...
June 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28646626/sexual-dimorphism-in-umbilical-vein-blood-flow-during-the-second-half-of-pregnancy-a-longitudinal-study
#5
Christian Widnes, Kari Flo, Tom Wilsgaard, Anthony O Odibo, Ganesh Acharya
OBJECTIVES: To investigate gestational age-specific serial changes in umbilical vein (UV) volume blood flow during the second half of normal pregnancy and establish sex-specific reference ranges. METHODS: This work was a prospective longitudinal study of singleton low-risk pregnancies. The UV diameter and maximum blood flow velocity were serially measured by sonography at the intra-abdominal portion of the UV over 19 to 41 weeks. Umbilical vein volume blood flow was calculated and normalized for estimated fetal weight...
June 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28646586/vaccine-candidate-discovery-for-the-next-generation-of-malaria-vaccines
#6
REVIEW
James Tuju, Gathoni Kamuyu, Linda M Murungi, Faith H A Osier
Although epidemiological observations, IgG passive transfer studies and experimental infections in humans all support the feasibility of developing highly effective malaria vaccines, the precise antigens that induce protective immunity remain uncertain. Here, we review the methodologies applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to post- genomic era. Probing of genomic and/or cDNA libraries with antibodies of defined specificities or functional activity predominated the former, while reverse vaccinology encompassing high throughput in silico analyses of genomic, transcriptomic or proteomic parasite datasets is the mainstay of the latter...
June 24, 2017: Immunology
https://www.readbyqxmd.com/read/28646578/the-impact-of-a-novel-transendometrial-approach-for-caesarean-myomectomy-on-obstetric-outcomes-of-subsequent-pregnancy-a-longitudinal-panel-study
#7
S Y Huang, S W Shaw, S Y Su, W F Li, H H Peng, P J Cheng
OBJECTIVE: To evaluate the obstetric and surgical outcomes of a novel transendometrial approach for myomectomy during caesarean section in subsequent pregnancies. DESIGN: Longitudinal panel study. SETTING: Chang Gung Memorial Hospital, Taiwan, with approximately 5000 births per annum. POPULATION: Pregnant women complicated with uterine myoma. METHOD: Sixty-three pregnant women who received transendometrial myomectomy during the first caesarean delivery reported a subsequent live pregnancy and planned an elective repeat caesarean delivery...
June 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28646503/personality-change-across-the-lifespan-insights-from-a-cross-cultural-longitudinal-study
#8
William J Chopik, Shinobu Kitayama
OBJECTIVE: Personality traits are characterized by both stability and change across the lifespan. Many of the mechanisms hypothesized to cause personality change (e.g., the timing of various social roles, physical health, and cultural values) differ considerably across culture. Moreover, personality consistency is valued highly in Western societies, but less so in non-Western societies. Few studies have examined how personality changes differently across cultures. METHOD: We employed a multi-level modeling approach to examine age-related changes in Big Five personality traits in two large panel studies of Americans (n = 6,259; Mage = 46...
June 23, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28646485/findings-from-the-harvard-medical-school-cambridge-integrated-clerkship-a-year-long-longitudinal-psychiatry-experience
#9
Elisa Cheng, David Hirsh, Elizabeth Gaufberg, Todd Griswold, J Wesley Boyd
OBJECTIVE: The Harvard Medical School Cambridge Integrated Clerkship is a longitudinal integrated clerkship that has provided an alternative clinical model for medical education in psychiatry since its inception in 2004. This study was undertaken in an effort to better understand the student experience of the Cambridge Integrated Clerkship and how it may have impacted students' perceptions of and interest in psychiatry, as well as performance. METHODS: Qualitative surveys were sent via e-mail to the first 11 student cohorts who had completed the Cambridge Integrated Clerkship (from 2004 to 2014) and for whom we had e-mail addresses (N = 100), and the free-text responses were coded thematically...
June 23, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28646480/preschool-gender-typed-play-behavior-at-age-3-5%C3%A2-years-predicts-physical-aggression-at-age-13%C3%A2-years
#10
Karson T F Kung, Gu Li, Jean Golding, Melissa Hines
Gender differences in play behavior and physical aggression have been consistently reported. Theoretical perspectives concerning evolutionary, social, and social-cognitive mechanisms suggest that male-typical play behavior during childhood increases subsequent physical aggression. The evidence supporting these connections is limited, however. The present study investigated the association between gender-typed play behavior in early childhood and physical aggression in early adolescence using a sample drawn from a longitudinal, population study, the Avon Longitudinal Study of Parents and Children...
June 23, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28646443/recent-discoveries-in-monogenic-disorders-of-childhood-bone-fragility
#11
REVIEW
Riikka E Mäkitie, Anders J Kämpe, Fulya Taylan, Outi Mäkitie
PURPOSE OF REVIEW: This review summarizes our current knowledge on primary osteoporosis in children with focus on recent genetic findings. RECENT FINDINGS: Advances in genetic research, particularly next-generation sequencing, have found several genetic loci that associate with monogenic forms of inherited osteoporosis, widening the scope of primary osteoporosis beyond classical osteogenesis imperfecta. New forms of primary osteoporosis, such as those related to WNT1, PLS3, and XYLT2, have identified defects outside the extracellular matrix components and collagen-related pathways, in intracellular cascades directly affecting bone cell function...
June 23, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28646381/stenotic-intercondylar-notch-type-is-correlated-with-anterior-cruciate-ligament-injury-in-female-patients-using-magnetic-resonance-imaging
#12
Theodoros Bouras, Peter Fennema, Stephen Burke, Hilary Bosman
PURPOSE AND HYPOTHESIS: The principal purpose of this paper was to identify whether femoral notch morphology was different in females without anterior cruciate ligament (ACL) injury from those with ACL injury. Magnetic resonance imaging (MRI) was used to assess the femoral notch type, notch width index and 'α angle' in female patients and measure these differences. METHODS: This is a retrospective case control study of 119 female patients, 58 with ACL injury and 61 patients without ACL injury who underwent knee MRI between March 2014 and April 2016...
June 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28646370/place-based-predictors-of-hiv-viral-suppression-and-durable-suppression-among-men-who-have-sex-with-men-in-new-york-city
#13
Kevin A Jefferson, Laura S Kersanske, Mary E Wolfe, Sarah L Braunstein, Regine Haardörfer, Don C Des Jarlais, Aimee N C Campbell, Hannah L F Cooper
We explore relationships between place characteristics and HIV viral suppression among HIV-positive men who have sex with men (MSM) in New York City (NYC). We conducted multilevel analyses to examine associations of United Hospital Fund (UHF)-level characteristics to individual-level suppression and durable suppression among MSM. Individual-level independent and dependent variables came from MSM in NYC's HIV surveillance registry who had been diagnosed in 2009-2013 (N = 7159). UHF-level covariates captured demographic composition, economic disadvantage, healthcare access, social disorder, and police stop and frisk rates...
June 23, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28646354/associations-between-race-and-eating-disorder-symptom-trajectories-in-black-and-white-girls
#14
Lindsay P Bodell, Jennifer E Wildes, Yu Cheng, Andrea B Goldschmidt, Kate Keenan, Alison E Hipwell, Stephanie D Stepp
Epidemiological research suggests racial differences in the presentation of eating disorder symptoms. However, no studies have examined associations between race and eating disorder symptom trajectories across youth and adolescence, which is necessary to inform culturally sensitive prevention programs. The purpose of the current study was to examine the trajectories of eating disorder symptoms from childhood to young adulthood and to examine whether race was associated with trajectory group membership. Data were drawn from 2,305 Black and White girls who participated in a community-based longitudinal cohort study (Pittsburgh Girls Study) examining the development of psychopathology...
June 23, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28646237/insulin-like-growth-factor-1-in-relation-to-future-hearing-impairment-findings-from-the-english-longitudinal-study-of-ageing
#15
Camille Lassale, G David Batty, Andrew Steptoe, Paola Zaninotto
Insulin-like Growth Factor 1 (IGF-1) is associated with cardiovascular disease, itself a risk factor for hearing impairment, and, in animal studies, molecular evidence suggests a role for IGF-1 in hearing function. However, the link between IGF-1 and the occurrence of hearing impairment is untested in population-based studies of humans. A total of 4390 participants aged ≥50 y (mean [SD] age 64.2 [8.0] years at baseline, 55% women) from the English Longitudinal Study of Ageing provided serum levels of IGF-1 in 2008 and again in 2012...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646162/associations-between-global-dna-methylation-and-telomere-length-in-healthy-adolescents
#16
Yutong Dong, Ying Huang, Bernard Gutin, Anas Raed, Yanbin Dong, Haidong Zhu
Emerging evidence suggests that epigenetics regulates telomere dynamics in adults. However, the relationship between these pathways in children and youth remains unknown. Thus, we examined this association in 542 healthy adolescents aged 14 to 18 years old (44.8% African Americans; 55.2% females). Global DNA methylation level (%5-mC) was quantified using ELISA method. Leukocyte telomere length (LTL) was defined as relative telomere to single copy gene (T/S) ratio. Multiple linear regression models, adjusted for age, gender, ethnicity, Tanner stage, BMI, PA, and batch effect, revealed that %5 mC was associated with LTL (adjusted β = 0...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646129/microscope-enhanced-the-efficacy-and-safety-of-anterior-cervical-surgery-for-managing-cervical-ossification-of-the-posterior-longitudinal-ligament
#17
Mingxiao Sun, Lili Kong, Zhaofu Jiang, Liming Li, Bing Lu
BACKGROUND We aimed to compare microscope-assisted anterior cervical surgery with traditional open-base surgery for treating cervical ossification of the posterior longitudinal ligament (OPLL). MATERIAL AND METHODS Patients were grouped into microscope-assisted anterior cervical surgery group (case group, n=30) and conventional anterior cervical surgery group (control group, n=30). Baseline characteristics, intraoperative and post-operative indexes including operation time, blood loss amount, duration of hospitalization, visual analogue scale (VAS), and complication rate were recorded...
June 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28646083/does-depression-increase-the-risk-of-stroke-in-patients-with-rheumatoid-arthritis-a-population-based-cohort-study
#18
Tzung-Yi Tsai, Ming-Chi Lu, Hanoch Livneh, Shan-Yun Chiu, Ning-Sheng Lai, How-Ran Guo
OBJECTIVES: Comorbid depression is common and undertreated in patients with rheumatoid arthritis (RA). It remains uncertain whether comorbid depression provoked the risk of poor clinical outcome, stroke in particular, among patients with RA. This work aimed to determine if depression onset during the treatment process increases stroke risk for patients with RA as compared with those with (1) neither RA nor depression, (2) RA only and (3) depression only. DESIGN: A nationwide, population-based cohort study...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28646016/tshb-mrna-is-linked-to-cholesterol-metabolism-in-adipose-tissue
#19
José María Moreno-Navarrete, María Moreno, Francisco Ortega, Gemma Xifra, Shangyu Hong, John M Asara, José C E Serrano, Mariona Jové, Pavlos Pissios, Matthias Blüher, Wifredo Ricart, Manuel Portero-Otin, José Manuel Fernández-Real
Subclinical hypothyroidism is known to be associated with increased serum cholesterol. Since thyroid-stimulating hormone (TSH) exerts an inductor effect on cholesterol biosynthesis, we aimed to investigate the relationship between TSH mRNA and cholesterol metabolism in human adipose tissue (AT). Cross-sectionally, AT TSH-β (TSHB) mRNA was evaluated in 4 independent cohorts in association with serum total and LDL cholesterol, and AT lipidomics. Longitudinally, the effects of statins and of diet and exercise on AT TSHB mRNA were also examined...
June 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28645981/work-related-psychosocial-factors-and-onset-of-metabolic-syndrome-among-workers-a-systematic-review-and-meta-analysis-protocol
#20
Asuka Sakuraya, Kazuhiro Watanabe, Norito Kawakami, Kotaro Imamura, Emiko Ando, Yumi Asai, Hisashi Eguchi, Yuka Kobayashi, Norimitsu Nishida, Hideaki Arima, Akihito Shimazu, Akizumi Tsutsumi
INTRODUCTION: Metabolic syndrome is an important public health target because of its high prevalence worldwide. Work-related psychosocial factors have been identified as determinants of metabolic syndrome components. However, there have been no systematic reviews or meta-analyses conducted to evaluate the relationship between work-related psychosocial factors and metabolic syndrome as an aggregated cluster. The aim of this study is to examine this association from published prospective studies...
June 22, 2017: BMJ Open
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