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https://www.readbyqxmd.com/read/28088618/modelling-possible-causality-in-the-associations-between-unemployment-cannabis-use-and-alcohol-misuse
#1
Joseph M Boden, Jungeun Olivia Lee, L John Horwood, Carolina Villamil Grest, Geraldine F H McLeod
BACKGROUND: There has been considerable interest in the extent to which substance use and unemployment may be related, particularly the causal pathways that may be involved in these associations. It has been argued that these associations may reflect social causation, in which unemployment influences substance use, or that they may reflect social selection, in which substance use increases the risk of becoming and remaining unemployed. The present study sought to test these competing explanations...
January 3, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28088581/a-stepwise-algorithm-using-a-at-a-glance-first-line-test-for-the-non-invasive-diagnosis-of-advanced-liver-fibrosis-and-cirrhosis
#2
Jérôme Boursier, Victor de Ledinghen, Vincent Leroy, Rodolphe Anty, Sven Francque, Dominique Salmon, Adrien Lannes, Sandrine Bertrais, Frederic Oberti, Isabelle Fouchard-Hubert, Paul Calès
BACKGROUND & AIMS: Chronic liver diseases (CLD) are highly frequent and thus mainly managed by non-hepatologists. Because they lack access to the best non-invasive tests of liver fibrosis, these physicians cannot accurately determine the disease severity and the need for referral to a hepatologist. We aimed to implement an algorithm, comprising a new first-line test usable by all physicians, for the detection of advanced liver fibrosis in all CLD patients. METHODS: Diagnostic study: 3,754 CLD patients with liver biopsy were 2:1 randomized into derivation and validation sets...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28088386/trypsin-induces-biphasic-muscle-contraction-and-relaxation-via-transient-receptor-potential-vanilloid-1-and-neurokinin-receptors-1-2-in-porcine-esophageal-body
#3
Bai Xiaopeng, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Kayoko Nakano, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura
Duodenal reflux of fluids containing trypsin relates to refractory gastroesophageal reflux disease (GERD). Esophageal peristalsis and clearance are important factors in GERD pathogenesis. However, the function of trypsin in esophageal body contractility is not fully understood. In this study, effects of trypsin on circular smooth muscle (CSM) and longitudinal smooth muscle (LSM) of the porcine esophageal body were examined. Trypsin elicited a concentration dependent biphasic response, a major contraction and a subsequent relaxation only in CSM...
January 11, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28088340/the-role-of-magnetic-resonance-imaging-techniques-in-evaluation-and-management-of-the-idiopathic-inflammatory-myopathies
#4
REVIEW
Jessica Day, Sandy Patel, Vidya Limaye
Magnetic resonance imaging (MRI) is an important tool in the evaluation of neuromuscular disorders. MRI accurately demonstrates muscle oedema, atrophy, subcutaneous pathology and fatty infiltration and also highlights the distribution of muscle involvement. This review examines the role of MRI in evaluation of the idiopathic inflammatory myopathies (IIMs), a heterogeneous group of autoimmune conditions characterised by muscle inflammation and a variety of extra-muscular manifestations. MRI has a clear role in aiding diagnosis of these conditions, guiding muscle biopsy, differentiating subtypes of IIM using a pattern-based approach, and monitoring disease activity in a longitudinal fashion...
November 5, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28088338/relation-between-resting-amygdalar-activity-and-cardiovascular-events-a-longitudinal-and-cohort-study
#5
Ahmed Tawakol, Amorina Ishai, Richard Ap Takx, Amparo L Figueroa, Abdelrahman Ali, Yannick Kaiser, Quynh A Truong, Chloe Je Solomon, Claudia Calcagno, Venkatesh Mani, Cheuk Y Tang, Willem Jm Mulder, James W Murrough, Udo Hoffmann, Matthias Nahrendorf, Lisa M Shin, Zahi A Fayad, Roger K Pitman
BACKGROUND: Emotional stress is associated with increased risk of cardiovascular disease. We imaged the amygdala, a brain region involved in stress, to determine whether its resting metabolic activity predicts risk of subsequent cardiovascular events. METHODS: Individuals aged 30 years or older without known cardiovascular disease or active cancer disorders, who underwent (18)F-fluorodexoyglucose PET/CT at Massachusetts General Hospital (Boston, MA, USA) between Jan 1, 2005, and Dec 31, 2008, were studied longitudinally...
January 12, 2017: Lancet
https://www.readbyqxmd.com/read/28088313/q-space-myelin-map-imaging-for-longitudinal-analysis-of-demyelination-and-remyelination-in-multiple-sclerosis-patients-treated-with-fingolimod-a-preliminary-study
#6
Mariko Tanikawa, Jin Nakahara, Junichi Hata, Shigeaki Suzuki, Kanehiro Fujiyoshi, Hirokazu Fujiwara, Suketaka Momoshima, Masahiro Jinzaki, Masaya Nakamura, Hideyuki Okano, Shinichi Takahashi, Norihiro Suzuki
BACKGROUND: Fingolimod (FTY) is an oral sphingosine-1-phosphate receptor modulator that reduces relapse and slows brain atrophy in multiple sclerosis (MS) patients. In addition, FTY has been shown to enhance remyelination in certain animal models. OBJECTIVE: To analyze feasibility of a novel q-space Myelin Map imaging to monitor demyelination and remyelination under FTY treatment in MS patients. METHODS: Treatment outcomes of 24 consecutive MS patients treated with FTY were analyzed...
January 5, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28088248/the-spectrum-of-rheumatic-in-patient-diagnoses-at-a-pediatric-hospital-in-kenya
#7
Angela Migowa, Inés Colmegna, Carol Hitchon, Eugene Were, Evelyn Ng'ang'a, Thomas Ngwiri, John Wachira, Sasha Bernatsky, Rosie Scuccimarri
BACKGROUND: Pediatric rheumatic diseases are chronic illnesses that can cause considerable disease burden to children and their families. There is limited epidemiologic data on these diseases in East Africa. The aim of this study was to assess the spectrum of pediatric rheumatic diagnoses in an in-patient setting and determine the accuracy of ICD-10 codes in identifying these conditions. METHODS: Medical records from Gertrude's Children's Hospital in Kenya were reviewed for patients diagnosed with "diseases of the musculoskeletal system and connective tissue" as per ICD-10 diagnostic codes assigned at discharge between January and December 2011...
January 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28088241/perceptions-of-mistreatment-among-trainees-vary-at-different-stages-of-clinical-training
#8
Afif N Kulaylat, Danni Qin, Susie X Sun, Christopher S Hollenbeak, Jane R Schubart, Antone J Aboud, Donald J Flemming, Peter W Dillon, Edward R Bollard, David C Han
BACKGROUND: Mistreatment of trainees remains a frequently reported phenomenon in medical education. One barrier to creating an educational culture of respect and professionalism may be a lack of alignment in the perceptions of mistreatment among different learners. Through the use of clinical vignettes, our aim was to assess the perceptions of trainees toward themes of potential mistreatment at different stages of training. METHODS: Based on observations from external experts embedded in the clinical learning environment, six thematic areas of potential mistreatment were identified: verbal abuse, specialty-choice discrimination, non-educational tasks, withholding/denying learning opportunities, neglect and gender/racial insensitivity...
January 14, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28088175/prevalence-and-risk-factors-for-cardiovascular-disease-among-chronic-kidney-disease-patients-results-from-the-chinese-cohort-study-of-chronic-kidney-disease-c-stride
#9
Jun Yuan, Xin-Rong Zou, Si-Ping Han, Hong Cheng, Lan Wang, Jin-Wei Wang, Lu-Xia Zhang, Ming-Hui Zhao, Xiao-Qin Wang
BACKGROUND: Although a high incidence of cardiovascular disease (CVD) is observed among chronic kidney disease (CKD) patients in developed countries, limited information is available about CVD prevalence and risk factors in the Chinese CKD population. The Chinese Cohort of Chronic Kidney Disease (C-STRIDE) was established to investigate the prevalence and risk factors of CVD among Chinese CKD patients. METHODS: Participants with stage 1-4 CKD (18-74 years of age) were recruited at 39 clinical centers located in 28 cities from 22 provinces of China...
January 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28088070/fatigue-life-of-bovine-meniscus-under-longitudinal-and-transverse-tensile-loading
#10
Jaremy J Creechley, Madison E Krentz, Trevor J Lujan
The knee meniscus is composed of a fibrous extracellular matrix that is subjected to large and repeated loads. Consequently, the meniscus is frequently torn, and a potential mechanism for failure is fatigue. The objective of this study was to measure the fatigue life of bovine meniscus when applying cyclic tensile loads either longitudinal or transverse to the principal fiber direction. Fatigue experiments consisted of cyclic loads to 60%, 70%, 80% or 90% of the predicted ultimate tensile strength until failure occurred or 20,000 cycles was reached...
December 27, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28088057/a-systematic-review-of-adult-attachment-and-social-anxiety
#11
REVIEW
Ray P C Manning, Joanne M Dickson, Jasper Palmier-Claus, Alexandra Cunliffe, Peter J Taylor
BACKGROUND: Attachment has been implicated in the development of social anxiety. Our aim was to synthesise the extant literature exploring the role of adult attachment in these disorders. METHOD: Search terms relating to social anxiety and attachment were entered into MEDLINE, PsycINFO and Web of Science. Risk of bias of included studies was assessed using and adapted version of the Agency for Healthcare Research and Quality assessment tool. Eligible studies employed validated social anxiety and attachment assessments in adult clinical and analogue samples...
December 19, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28088056/the-evolving-relationship-between-premorbid-intelligence-and-serious-depression-across-the-lifespan-a-longitudinal-study-of-43-540-swedish-men
#12
Emil Lager, Bo Melin, Tomas Hemmingsson, Alma Sörberg Wallin
BACKGROUND: An association between higher intelligence and lower probability of serious depression has previously been established. Yet, to our knowledge, no large prospective study has examined the relationship across the lifespan. METHODS: A cohort of 49,321 Swedish men was followed from conscription in 1969-70 (age 18-20) through to 2008. Odds ratios (OR) for first time hospitalisation for depression (FTHD) were calculated in relation to intelligence for distinct time periods across the lifespan, while controlling for established risk factors for depression...
January 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28088029/an-updated-meta-analysis-of-cohort-studies-diabetes-and-risk-of-alzheimer-s-disease
#13
REVIEW
Jieyu Zhang, Chunxiang Chen, Shuizhen Hua, Hairong Liao, Meixiang Wang, Yan Xiong, Fei Cao
BACKGROUND: In recently, several large longitudinal population-based studies have shown that the rate of cognitive decline is accelerated in elderly people with diabetes mellitus. But the relation between diabetes and AD is still an area of controversy. The objective of this review was to update the evidence for or against diabetes as a risk factor of AD. METHODS: We searched the literature from their inception to May 2016 without restriction of language. We included all longitudinal population-based studies examining the association between diabetes and risk of AD...
November 9, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28087834/environmental-deflection-the-impact-of-toxicant-exposures-on-the-aging-epigenome
#14
Joseph Kochmanski, Luke Montrose, Jaclyn M Goodrich, Dana C Dolinoy
Epigenetic drift and age-related methylation have both been used in the literature to describe changes in DNA methylation that occurs with aging. However, ambiguity remains regarding the exact definition of both of these terms, and neither of these fields of study explicitly considers the impact of environmental factors on the aging epigenome. Recent twin studies have demonstrated longitudinal, pair-specific discordance in DNA methylation patterns, suggesting an effect of the environment on age-related methylation and/or epigenetic drift...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28087797/the-cascading-effects-of-marginalization-and-pathways-of-resilience-in-attaining-good-health-among-lgbt-older-adults
#15
Karen I Fredriksen-Goldsen, Hyun-Jun Kim, Amanda E B Bryan, Chengshi Shiu, Charles A Emlet
PURPOSE OF THE STUDY: Lesbian, gay, bisexual, and transgender (LGBT) older adults comprise a diverse and growing health disparate population. In the present study, using the Health Equity Promotion Model, we investigated pathways by which LGBT older adults experience resilience, risk, and marginalization and their relationship to attaining positive health outcomes. DESIGN AND METHODS: Aging with Pride: National Health, Aging, and Sexuality/Gender Study (NHAS) is the first longitudinal research project designed to examine the health, aging, and well-being of LGBT adults aged 50 and older...
February 2017: Gerontologist
https://www.readbyqxmd.com/read/28087795/who-says-i-do-the-changing-context-of-marriage-and-health-and-quality-of-life-for-lgbt-older-adults
#16
Jayn Goldsen, Amanda E B Bryan, Hyun-Jun Kim, Anna Muraco, Sarah Jen, Karen I Fredriksen-Goldsen
PURPOSE OF THE STUDY: Until recently, lesbian, gay, bisexual, and transgender (LGBT) adults were excluded from full participation in civil marriage. The purpose of this study is to examine how legal marriage and relationship status are associated with health-promoting and at-risk factors, health, and quality of life of LGBT adults aged 50 and older. DESIGN AND METHODS: We utilized weighted survey data from Aging with Pride: National Health, Aging, and Sexuality/Gender Study (NHAS) participants who resided in states with legalized same-sex marriage in 2014 (N = 1,821)...
February 2017: Gerontologist
https://www.readbyqxmd.com/read/28087794/bouncing-back-resilience-and-mastery-among-hiv-positive-older-gay-and-bisexual-men
#17
Charles A Emlet, Chengshi Shiu, Hyun-Jun Kim, Karen Fredriksen-Goldsen
PURPOSE OF THE STUDY: Adults with HIV infection are living into old age. It is critical we investigate positive constructs such as resilience and mastery to determine factors associated with psychological well-being. We examine HIV-related factors, adverse conditions, and psychosocial characteristics that are associated with resilience (the ability to bounce back) and mastery (sense of self-efficacy). DESIGN AND METHODS: We analyzed 2014 data from the longitudinal study Aging with Pride: National Health, Aging, and Sexuality/Gender Study (NHAS), focusing on a subsample of 335 gay and bisexual older men...
February 2017: Gerontologist
https://www.readbyqxmd.com/read/28087792/the-unfolding-of-lgbt-lives-key-events-associated-with-health-and-well-being-in-later-life
#18
Karen I Fredriksen-Goldsen, Amanda E B Bryan, Sarah Jen, Jayn Goldsen, Hyun-Jun Kim, Anna Muraco
PURPOSE OF THE STUDY: Life events are associated with the health and well-being of older adults. Using the Health Equity Promotion Model, this article explores historical and environmental context as it frames life experiences and adaptation of lesbian, gay, bisexual, and transgender (LGBT) older adults. DESIGN AND METHODS: This was the largest study to date of LGBT older adults to identify life events related to identity development, work, and kin relationships and their associations with health and quality of life (QOL)...
February 2017: Gerontologist
https://www.readbyqxmd.com/read/28087676/the-longitudinal-study-of-aging-in-human-young-adults-knowledge-gaps-and-research-agenda
#19
Terrie E Moffitt, Daniel W Belsky, Andrea Danese, Richie Poulton, Avshalom Caspi
BACKGROUND: To prevent onset of age-related diseases and physical and cognitive decline, interventions to slow human aging and extend health span must eventually be applied to people while they are still young and healthy. Yet most human aging research examines older adults, many with chronic disease, and little is known about aging in healthy young humans. METHOD: This article explains how this knowledge gap is a barrier to extending health span and puts forward the case that geroscience should invest in researching the pace of aging in young adults...
February 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28087557/a-longitudinal-comparative-study-of-falls-in-persons-with-knee-arthroplasty-and-persons-with-or-at-high-risk-for-knee-osteoarthritis
#20
Daniel L Riddle, Gregory J Golladay
No abstract text is available yet for this article.
January 13, 2017: Age and Ageing
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