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https://www.readbyqxmd.com/read/28351070/does-resection-of-the-posterior-longitudinal-ligament-impact-the-incidence-of-c5-palsy-after-cervical-corpectomy-procedures-a-review-of-459-consecutive-cases
#1
Ahmad Nassr, Ilyas S Aleem, Jason C Eck, Barrett Woods, Ravi K Ponnappan, William F Donaldson, James D Kang
STUDY DESIGN: Retrospective review. OBJECTIVE: To evaluate key risk factors for the development of C5 palsy after cervical corpectomy, including resection of the posterior longitudinal ligament (PLL). SUMMARY OF BACKGROUND DATA: Postoperative C5 palsy is a well-known complication after cervical spine surgery. It is unknown whether resection of the PLL affects the incidence of C5 palsy. METHODS: We performed a retrospective review of 459 consecutive patients undergoing anterior cervical corpectomies over a 15-year period...
April 1, 2017: Spine
https://www.readbyqxmd.com/read/28350539/personalized-precision-medicine-in-extreme-preterm-infants-with-transient-neonatal-diabetes-mellitus
#2
Ranjit I Kylat, Rajan Senguttuvan, Mohammed Y Bader
Although hyperglycemia is common in neonates, especially preterm infants, a diagnosis of neonatal diabetes mellitus (NDM) is rarely made. NDM can be permanent (45%), transient (45%) or syndromic (10%). Of the 95% of identifiable mutations for NDM, methylation defects in 6q24, KCNJ11, ABCC8, and INS account for the majority. Two cases of transient NDM in extremely preterm, 24 weeks' gestational age (GA) triplets, due to a missense mutation c.685G>A in the KCNJ11 gene are presented. Both patients were successfully transitioned from insulin to Glyburide (Glibenclamide) at 2 months of age...
March 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28346935/dysbiosis-in-the-neonatal-period-role-of-cesarean-section
#3
Josef Neu
From epidemiological studies and studies done evaluating microbiomes in infants, there is a strong signal that the infants born by elective cesarean section (C-section) develop microbiota that differs from those babies born by vaginal delivery. Epidemiological studies show increased odds ratios for the development of immunological disorders such as type 1 diabetes, celiac disease, asthma, allergic diseases as well as metabolic diseases such as obesity in babies born by C-section. These are interesting associations, and if supported by additional studies that rigorously control for confounding factors, they will have major public health implications...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346858/circulating-soluble-il-6-receptor-concentration-and-visceral-adipocyte-size-are-related-to-insulin-resistance-in-taiwanese-adults-with-morbid-obesity
#4
Feng-Chih Kuo, Ya-Hsien Huang, Fu-Huang Lin, Yi-Jen Hung, Chang-Hsun Hsieh, Chieh-Hua Lu, Sheng-Chiang Su, Chia-Luen Huang, Chien-Hsing Lee, Nain-Feng Chu
BACKGROUND: Morbid obesity is related to chronic inflammation and many metabolic complications. Interleukin (IL)-6 plays a pivotal pathophysiological role in obesity, and IL-6 trans-signaling through the soluble IL-6 receptor (sIL-6R) has a major proinflammatory effect. The aim of this study was to investigate the association between sIL-6R, adipocyte size, and insulin resistance in morbidly obese individuals. METHODS: We measured concentrations of sIL-6R, high-sensitivity C-reactive protein, and lipid parameters and estimated homeostasis model assessment of insulin resistance (HOMA-IR) before the patients underwent bariatric surgery...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346853/high-prevalence-of-vitamin-d-deficiency-and-correlation-of-serum-vitamin-d-with-cardiovascular-risk-in-patients-with-metabolic-syndrome
#5
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
BACKGROUND: Metabolic syndrome (MetS) identifies subjects with increased risk of cardiovascular disease when they have a combination of insulin resistance, obesity, hypertension, hyperglycemia, low high-density lipoprotein cholesterol (HDL-C), and elevated triglycerides (TGs). Increasing evidence suggests that vitamin D deficiency could be associated with diabetes and MetS. The aim is to assess if 25-hydroxyvitamin D (25-OHD) is correlated with cardiovascular risk components of MetS. METHODS: A cross-sectional study involved 124 diabetic patients with MetS according to International Diabetes Federation definition...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346573/assessment-of-glycemic-control-in-nursing-home-residents-with-diabetes
#6
F Retornaz, M Grino, L Mari, C Oliver
OBJECTIVE: To describe glycemic control in nursing home residents with diabetes and to evaluate the relevance of HbA1c in the detection of hypoglycemia risk. DESIGN AND METHODS: Diabetes treatment, geriatric assessment, blood capillary glucose (n= 24,682), and HbA1c were collected from medical charts of 236 southern France nursing home residents during a 4-month period. Glycemic control was divided into four categories: tight, fair, and moderate or severe chronic hyperglycemia using the High Blood Glucose Index or the analysis of blood glucose frequency distribution...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346567/effect-of-a-low-glycemic-index-mediterranean-diet-on-non-alcoholic-fatty-liver-disease-a-randomized-controlled-clinici-trial
#7
G Misciagna, M Del Pilar Díaz, D V Caramia, C Bonfiglio, I Franco, M R Noviello, M Chiloiro, D I Abbrescia, A Mirizzi, M Tanzi, M G Caruso, M Correale, R Reddavide, R Inguaggiato, A M Cisternino, A R Osella
INTRODUCTION: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). DESIGN: NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346408/gut-microbial-metabolites-limit-the-frequency-of-autoimmune-t-cells-and-protect-against-type-1-diabetes
#8
Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap, Jacinta Knight, Craig McKenzie, Jan Kranich, Ana Carolina Oliveira, Fernando J Rossello, Balasubramanian Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, Julie M Clarke, David L Topping, Leonard C Harrison, Charles R Mackay
Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese diabetic (NOD) strain, we found that key features of disease correlated inversely with blood and fecal concentrations of the microbial metabolites acetate and butyrate. We therefore fed NOD mice specialized diets designed to release large amounts of acetate or butyrate after bacterial fermentation in the colon. Each diet provided a high degree of protection from diabetes, even when administered after breakdown of immunotolerance...
March 27, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28346406/diabetes-reversal-by-inhibition-of-the-low-molecular-weight-tyrosine-phosphatase
#9
Stephanie M Stanford, Alexander E Aleshin, Vida Zhang, Robert J Ardecky, Michael P Hedrick, Jiwen Zou, Santhi R Ganji, Matthew R Bliss, Fusayo Yamamoto, Andrey A Bobkov, Janna Kiselar, Yingge Liu, Gregory W Cadwell, Shilpi Khare, Jinghua Yu, Antonio Barquilla, Thomas D Y Chung, Tomas Mustelin, Simon Schenk, Laurie A Bankston, Robert C Liddington, Anthony B Pinkerton, Nunzio Bottini
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases...
March 27, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28346347/biosynthesis-of-%C3%AE-glucosidase-inhibitors-by-a-newly-isolated-bacterium-paenibacillus-sp-tku042-and-its-effect-on-reducing-plasma-glucose-in-a-mouse-model
#10
Van Bon Nguyen, Anh Dzung Nguyen, Yao-Haur Kuo, San-Lang Wang
Paenibacillus sp. TKU042, a bacterium isolated from Taiwanese soil, produced α-glucosidase inhibitors (aGIs) in the culture supernatant when commercial nutrient broth (NB) was used as the medium for fermentation. The supernatant of fermented NB (FNB) showed stronger inhibitory activities than acarbose, a commercial anti-diabetic drug. The IC50 and maximum α-glucosidase inhibitory activities (aGIA) of FNB and acarbose against α-glucosidase were 81 μg/mL, 92% and 1395 μg/mL, 63%, respectively. FNB was found to be strongly thermostable, retaining 95% of its relative activity, even after heating at 100 °C for 30 min...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28346156/association-of-sleep-characteristics-with-cardiovascular-and-metabolic-risk-factors-in-a-population-sample-the-chicago-area-sleep-study
#11
Samantha E Montag, Kristen L Knutson, Phyllis C Zee, Jeffrey J Goldberger, Jason Ng, Kwang-Youn A Kim, Mercedes R Carnethon
OBJECTIVES: To investigate the association of sleep characteristics with prevalent hypertension, diabetes, and obesity in a multiethnic cohort. DESIGN: This study used a population-based cross-sectional study design. SETTING: Participants were recruited between 2009 and 2011 from Chicago, Illinois, and the surrounding suburbs. PARTICIPANTS: Participants were 492 adults aged 35 to 64years who self-reported as white, black, Hispanic, or Asian and who had a low likelihood of sleep apnea based on the apnea screening questionnaires and 1 night of apnea screening using an in-home device (apnea hypopnea index <15 or oxygen desaturation index <10)...
April 2017: Sleep Health
https://www.readbyqxmd.com/read/28345814/dapagliflozin-once-daily-plus-exenatide-once-weekly-in-obese-adults-without-diabetes-sustained-reductions-in-bodyweight-glycaemia-and-blood-pressure-over-1-year
#12
Per Lundkvist, Maria J Pereira, Petros Katsogiannos, C David Sjöström, Eva Johnsson, Jan W Eriksson
AIMS: Dapagliflozin and exenatide reduce bodyweight by differing mechanisms. Dual therapy with these agents reduces bodyweight, adipose tissue volume, glycaemia, and systolic blood pressure (SBP) over 24 weeks. Here, we examined these effects over 1 year in obese adults without diabetes. MATERIALS AND METHODS: Obese adults without diabetes (N = 50; aged 18-70 years; body mass index 30-45 kg/m(2) ) initially randomized to double-blind oral dapagliflozin 10 mg once daily plus subcutaneous long-acting exenatide 2 mg once weekly or placebo entered an open-label extension from 24-52 weeks during which all participants received active treatment...
March 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28345762/short-term-effects-of-low-carbohydrate-diet-on-glycaemic-parameters-and-cardiovascular-risk-markers-in-patients-with-type-1-diabetes-a-randomised-open-label-cross-over-trial
#13
A Ranjan, S Schmidt, C Damm-Frydenberg, J Holst, S Madsbad, K Nørgaard
The objective was to compare effects of high carbohydrate diet (HCD) versus low carbohydrate diet (LCD) on glycaemic parameters and cardiovascular risk markers in patients with type 1 diabetes. Ten patients (4 women, insulin pump-treated, median±SD age: 48 ± 10 years, HbA1c: 53 ± 6 mmol/mol (7.0 ± 0.6%)) followed one week of isocaloric HCD (≥250 g/day) and one week of isocaloric LCD (≤50 g/day) in random order. After each week, we downloaded pump and sensor data and collected fasting blood and urine samples...
March 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28345384/parental-evaluation-of-a-telemonitoring-service-for-children-with-type-1-diabetes
#14
E Losiouk, G Lanzola, S Del Favero, F Boscari, M Messori, I Rabbone, R Bonfanti, A Sabbion, D Iafusco, R Schiaffini, R Visentin, S Galasso, F Di Palma, D Chernavvsky, L Magni, C Cobelli, D Bruttomesso, S Quaglini
Introduction In the past years, we developed a telemonitoring service for young patients affected by Type 1 Diabetes. That service provides data to the clinical staff and offers an important tool to the parents, that are able to oversee in real time their children. The aim of this work was to analyze the parents' perceived usefulness of the service. Methods The service was tested by the parents of 31 children enrolled in a seven-day clinical trial during a summer camp. To study the parents' perception we proposed and analyzed two questionnaires...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28345162/reduction-of-postprandial-glucose-by-lixisenatide-versus-sitagliptin-in-japanese-patients-with-type-2-diabetes-on-background-insulin-glargine-a-randomised-phase-4-study
#15
Yuichiro Yamada, Masayuki Senda, Yusuke Naito, Masahiro Tamura, Daisuke Watanabe, Yujin Shuto, Yoshihisa Urita
AIM: To evaluate the pharmacodynamics of adjunctive lixisenatide once daily versus sitagliptin once daily in Japanese patients with type 2 diabetes receiving insulin glargine U100. METHODS: This multicentre, open-label, phase 4 study (NCT02200991) randomly assigned 136 patients to either lixisenatide once-daily subcutaneous injection (10 µg initially increased weekly by 5 µg up to 20 µg) or once-daily oral sitagliptin (50 mg dose). The primary endpoint was the change in postprandial glucose (PPG) exposure 4 hours after a standardized breakfast (PPG area under the plasma glucose concentration-time curve [AUC0:00-4:00h ]) from baseline to Day 29...
March 26, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28345135/eliminating-cows-milk-but-not-wheat-barley-or-rye-increases-the-risk-of-growth-deceleration-and-nutritional-inadequacies
#16
Jetta Tuokkola, Päivi Luukkainen, Jaakko Nevalainen, Suvi Ahonen, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Mikael Knip, Suvi M Virtanen, Minna Kaila
AIM: Our study examined the growth and nutritional intake of children on milk and, or, wheat, barley or rye elimination diets. METHODS: This was a nested case-control study within the Finnish Type 1 Diabetes Prediction and Prevention Study. It investigated 295 children born in the Tampere University Hospital area between 1997-2004 on a diet without cows' milk and, or, wheat, barley or rye due to food allergies and 265 matched controls. Nutritional intake was recorded with three-day food records at the ages of one, two and three years...
March 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28344903/comparison-of-consumption-behavior-and-appetite-sensations-among-patients-with-type-2-diabetes-mellitus-after-bariatric-surgery
#17
Chun Yeh, Hsien-Hao Huang, Shu-Chun Chen, Tung-Fang Chen, Kong-Han Ser, Chih-Yen Chen
BACKGROUND: The promising postsurgical weight loss and remission of type 2 diabetes (T2D) from bariatric surgery can be attributed to modified eating physiology after surgical procedures. We sought to investigate the changes in the parameters of consumption behaviors and appetite sensations induced by a mixed meal tolerance test, and to correlate these alterations with age, body mass index, C-peptide levels, and duration of T2D 1 year after bariatric surgery. METHODS: A total of 16 obese patients with T2D who underwent mini-gastric bypass (GB) and 16 patients who underwent sleeve gastrectomy (SG) were enrolled in this study and evaluated using a mixed meal tolerance test one year after surgery...
2017: PeerJ
https://www.readbyqxmd.com/read/28344753/statin-testosterone-and-phosphodiesterase-5-inhibitor-treatments-and-age-related-mortality-in-diabetes
#18
Geoffrey Hackett, Peter W Jones, Richard C Strange, Sudarshan Ramachandran
AIM: To determine how statins, testosterone (T) replacement therapy (TRT) and phosphodiesterase 5-inhibitors (PDE5I) influence age related mortality in diabetic men. METHODS: We studied 857 diabetic men screened for the BLAST study, stratifying them (mean follow-up = 3.8 years) into: (1) Normal T levels/untreated (total T > 12 nmol/L and free T > 0.25 nmol/L), Low T/untreated and Low T/treated; (2) PDE5I/untreated and PDE5I/treated; and (3) statin/untreated and statin/treated groups...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28344449/the-effects-of-3-weeks-of-uphill-and-downhill-walking-on-blood-lipids-and-glucose-metabolism-in-pre-diabetic-men-a-pilot-study
#19
Marc Philippe, Hannes Gatterer, Erika Maria Eder, Alexander Dzien, Matthias Somavilla, Andreas Melmer, Christoph Ebenbichler, Tom Müller, Martin Burtscher
The prevention of type 2 diabetes in persons at risk for diabetes is of utmost importance. Physical activity in general and even exercises at moderate intensities such as walking significantly reduce the risk of the development of type 2 diabetes. However, it is still a matter of debate whether lipids and glucose metabolism are differently affected by regular concentric (e.g., uphill walking) and eccentric (e.g., downhill walking) endurance exercise. The aim of this study was to investigate the effects of short-term (3 weeks) uphill and downhill walking on glucose metabolism and blood lipids in pre-diabetic middle-aged men in a real world setting...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28344207/dipeptidyl-peptidase-iv-inhibition-for-the-treatment-of-cardiovascular-disease%C3%A3-recent-insights-focusing-on-angiogenesis-and-neovascularization
#20
Yanna Lei, Lina Hu, Guang Yang, Limei Piao, Minggen Jin, Xianwu Cheng
Dipeptidyl peptidase IV (DPP-IV) is a complex enzyme that acts as a membrane-anchored cell surface exopeptidase and transmits intracellular signals through a small intracellular tail. DPP-IV exists in human blood in a soluble form, and truncates a large number of peptide hormones, chemokines, cytokines, and growth factors in vitro and in vivo. DPP-IV has gained considerable interest as a therapeutic target, and a variety of DPP-IV inhibitors that prolong the insulinotropic effects of glucagon-like peptide-1 (GLP-1) are widely used in clinical settings as antidiabetic drugs...
March 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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