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small stone syndrome

Filiz Serdaroglu, Yavuz S Koca, Fatma Saltik, Tugba Koca, Selim Dereci, Mustafa Akcam, Fusun Z Akcam
AIM: The aim of this study was to determine demographic and clinical features in children diagnosed with gallstones, risk factors for gallstone formation, the effectiveness of ursodeoxycholic acid therapy, and the course of the disease. MATERIALS AND METHODS: Patients aged 0-18 years were followed up for at least 6 months after the diagnosis of gallstones with ultrasonography and were evaluated retrospectively. Patients were evaluated with respect to age, sex, presenting symptoms, BMI, facilitating factors, accompanying diseases, family history of gallstones, history of ceftriaxone use, laboratory tests, ultrasonography findings and follow-up, and therapeutic approaches and results...
August 18, 2016: European Journal of Gastroenterology & Hepatology
Rama Subba Rao Vidadala, Kasey L Rivas, Kayode K Ojo, Matthew A Hulverson, Jennifer A Zambriski, Igor Bruzual, Tracey L Schultz, Wenlin Huang, Zhongsheng Zhang, Suzanne Scheele, Amy E DeRocher, Ryan Choi, Lynn K Barrett, Latha Kallur Siddaramaiah, Wim G J Hol, Erkang Fan, Ethan A Merritt, Marilyn Parsons, Gail Freiberg, Kennan Marsh, Dale J Kempf, Vern B Carruthers, Nina Isoherranen, J Stone Doggett, Wesley C Van Voorhis, Dustin J Maly
New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent and selective inhibitor (compound 1) of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) that possesses antitoxoplasmosis activity in vitro and in vivo. Unfortunately, 1 has potent human ether-a-go-go-related gene (hERG) inhibitory activity, associated with long Q-T syndrome, and consequently presents a cardiotoxicity risk...
July 14, 2016: Journal of Medicinal Chemistry
Loris Pironi
The European Society for Clinical Nutrition and Metabolism defined intestinal failure (IF) as "the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth". IF is classified as type 1-acute, type 2-prolonged acute and type 3-chronic IF. A short bowel syndrome (SBS) due to the intestinal malabsorption associated with a functional small intestine length of less than 200 cm is the most frequent mechanism of IF...
April 2016: Best Practice & Research. Clinical Gastroenterology
Sławomir Kozieł, Piotr Papaj, Katarzyna Dobija-Kubica, Przemysław Śleziński, Józef Wróbel
Cholelithiasis is diagnosed in 10% of the population of the USA and Western Europe. A rare but serious complication of cholelithiasis is the obstruction of the digestive tract caused by a gall-stone (Bernard syndrome). It can add up to 1-4% of the mechanical obstructions of a small intestine among the general population but it can result in nonstriangulational mechanical obstructions of a small intestine in 25% cases among the patients over the age of 65. 5 patients have undergone an operation due to a small intestine gall-stone ileus in years 2011-2013 (within 27 months) in the General Surgery Ward of the Beskid Oncology Center - Municipal Hospital...
May 2015: Polski Przeglad Chirurgiczny
Nicholas Young, John Newton, John Morris, Joan Morris, John Langford, Jonathan Iloya, Diane Edwards, Semina Makhani, Julia Verne
BACKGROUND: Six million people in England live in areas where the level of fluoride in water is adjusted to reduce the significant public health burden of dental caries. The dental effects of fluoride are well established, but evidence for suggested adverse health effects is limited, with a lack of rigorous small area population studies that control for confounding. This study aims to test the association between water fluoridation schemes and selected health outcomes using the best available routine data sources...
December 2015: Community Dentistry and Oral Epidemiology
Laura Hope-Stone, Stephen L Brown, Heinrich Heimann, Bertil Damato, Peter Salmon
PURPOSE: Patients undergoing enucleation for uveal melanoma need to be informed of the possibility of phantom eye syndrome (PES). The number with uveal melanoma in PES studies has been small. Aims were to: (1) determine the prevalence, symptoms, and characteristics of PES and to test associations of PES symptoms with sociodemographic and clinical characteristics; (2) examine the interrelatedness of PES symptoms; and (3) explore the emotional valence of PES and the relationship to anxiety and depression...
August 2015: Ophthalmology
Daniel A Roberts, Martha Wadleigh, Anne M McDonnell, Daniel J DeAngelo, Richard M Stone, David P Steensma
Clofarabine, a second-generation nucleoside analog, has clinical activity in relapsed or refractory acute myelogenous leukemia (AML) and higher-risk myelodysplastic syndromes (MDS). However, there are few data evaluating performance of clofarabine in populations of patients not enrolled in clinical trials. We reviewed outcomes for 84 patients treated with clofarabine for relapsed or refractory AML or MDS, either with clofarabine as monotherapy (n=19) or in combination with cytarabine (n=65). Using International Working Group (IWG) response criteria, the overall response rate (ORR) of all treated patients was 21%, with a complete response rate with either complete or incomplete hematopoietic recovery (CRR=CR+CRi) of 14%...
February 2015: Leukemia Research
Zain Majid, Irfan Masood, Muhammad Taqi Pirzada
Around the world, Ascaris lumbricoides is the most common helminthic infection. We describe the case of a 25-year-old woman, known to have had Ascaris infestation, presenting with abdominal pain, constipation and jaundice together with fever and tachycardia. There was tenderness in the right hypochondrium and liver function tests confirmed cholestatic jaundice. An abdominal ultrasound showed multiple linear echogenic foci in the distal small intestine along with cholelithiasis and a thick-walled gall bladder with a single stone compressing the common bile duct (Mirizzi syndrome)...
April 2015: Tropical Doctor
Vasilios G Athyros, Efstathios D Pagourelias, Thomas D Gossios, Vasilios G Vasilikos
Heart failure with preserved ejection fraction (HFpEF). Arterial hypertension (AH), arterial stiffness (AS), older age, and female gender are the main determinants of HFpEF, but several cardiac or extra-cardiac pathologies are also possible causes. The combined ventricular-vascular stiffening (abnormal left atrium-left ventricle coupling related to AS) is the main contributor of the increased prevalence of HFpEF in elderly persons, particularly elderly women, and in younger persons with AH. The hospitalization and mortality rates of HFpEF are similar to those of heart failure with reduced EF (HFrEF)...
2015: Current Vascular Pharmacology
Richard M Tsai, Adam L Boxer
Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative diseases with heterogeneous clinical presentations and two predominant types of underlying neuropathology. FTD typically comprises three distinct clinical syndromes: behavioral variant frontotemporal dementia (bvFTD), semantic variant primary progressive aphasia (svPPA), and nonfluent variant primary progressive aphasia (nfvPPA). FTD also frequently overlaps both clinically and neuropathologically with three other neurodegenerative syndromes: corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)...
November 2014: Current Treatment Options in Neurology
Wen Zhong, Gioacchino Leto, Liang Wang, Guohua Zeng
OBJECTIVE: To evaluate the risk factors for systemic inflammatory response syndrome (SIRS) after flexible ureteroscopic lithotripsy (FUL). MATERIALS AND METHODS: Patients who underwent FUL between October 2012 and November 2013 were studied. Complete data was available for 260 adult patients who met this criteria. Preoperative and intraoperative risk factors that potentially contribute to SIRS were compared in patients who developed postoperative SIRS and those who did not...
January 2015: Journal of Endourology
Philippe Généreux, Mahesh V Madhavan, Gary S Mintz, Akiko Maehara, Tullio Palmerini, Laura Lasalle, Ke Xu, Tom McAndrew, Ajay Kirtane, Alexandra J Lansky, Sorin J Brener, Roxana Mehran, Gregg W Stone
OBJECTIVES: This study sought to determine the frequency and impact of coronary calcification among patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS). BACKGROUND: Small studies in patients with stable coronary artery disease have suggested a worse prognosis after PCI of calcified compared with noncalcified lesions. Little is known about the impact of coronary calcification on outcomes after PCI for patients presenting with non-ST-segment elevation and ST-segment elevation ACS...
May 13, 2014: Journal of the American College of Cardiology
Qing Zhou, Dan Yang, Amanda K Ombrello, Andrey V Zavialov, Camilo Toro, Anton V Zavialov, Deborah L Stone, Jae Jin Chae, Sergio D Rosenzweig, Kevin Bishop, Karyl S Barron, Hye Sun Kuehn, Patrycja Hoffmann, Alejandra Negro, Wanxia L Tsai, Edward W Cowen, Wuhong Pei, Joshua D Milner, Christopher Silvin, Theo Heller, David T Chin, Nicholas J Patronas, John S Barber, Chyi-Chia R Lee, Geryl M Wood, Alexander Ling, Susan J Kelly, David E Kleiner, James C Mullikin, Nancy J Ganson, Heidi H Kong, Sophie Hambleton, Fabio Candotti, Martha M Quezado, Katherine R Calvo, Hawwa Alao, Beverly K Barham, Anne Jones, James F Meschia, Bradford B Worrall, Scott E Kasner, Stephen S Rich, Raphaela Goldbach-Mansky, Mario Abinun, Elizabeth Chalom, Alisa C Gotte, Marilynn Punaro, Virginia Pascual, James W Verbsky, Troy R Torgerson, Nora G Singer, Timothy R Gershon, Seza Ozen, Omer Karadag, Thomas A Fleisher, Elaine F Remmers, Shawn M Burgess, Susan L Moir, Massimo Gadina, Raman Sood, Michael S Hershfield, Manfred Boehm, Daniel L Kastner, Ivona Aksentijevich
BACKGROUND: We observed a syndrome of intermittent fevers, early-onset lacunar strokes and other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic vasculopathy in three unrelated patients. We suspected a genetic cause because the disorder presented in early childhood. METHODS: We performed whole-exome sequencing in the initial three patients and their unaffected parents and candidate-gene sequencing in three patients with a similar phenotype, as well as two young siblings with polyarteritis nodosa and one patient with small-vessel vasculitis...
March 6, 2014: New England Journal of Medicine
Joaquin Escribano, Albert Balaguer, Marta Roqué i Figuls, Albert Feliu, Natalia Ferre
BACKGROUND: Idiopathic hypercalciuria is an inherited metabolic abnormality that is characterised by excessive amounts of calcium excreted in the urine by people whose calcium serum levels are normal. Morbidity associated with idiopathic hypercalciuria is chiefly related to kidney stone disease and bone demineralisation leading to osteopenia and osteoporosis. Idiopathic hypercalciuria contributes to kidney stone disease at all life stages; people with the condition are prone to developing oxalate and calcium phosphate kidney stones...
2014: Cochrane Database of Systematic Reviews
Kelly A Tappenden
The human small intestine is organized with a proximal-to-distal gradient of mucosal structure and nutrient processing capacity. However, certain nutrients undergo site-specific digestion and absorption, such as iron and folate in the duodenum/jejunum vs vitamin B12 and bile salts in the ileum. Intestinal resection can result in short bowel syndrome (SBS) due to reduction of total and/or site-specific nutrient processing areas. Depending on the segment(s) of intestine resected, malabsorption can be nutrient specific (eg, vitamin B12 or fat) or sweeping, with deficiencies in energy, protein, and various micronutrients...
May 2014: JPEN. Journal of Parenteral and Enteral Nutrition
Matthew D Stone, Stephen B Harvey, Gary L Nelsestuen, Cavan Reilly, Marshall I Hertz, Chris H Wendt
OBJECTIVE: The objective of this discovery-level investigation was to use mass spectrometry to identify low mass compounds in bronchoalveolar lavage fluid from lung transplant recipients that associate with bronchiolitis obliterans syndrome. EXPERIMENTAL DESIGN: Bronchoalveolar lavage fluid samples from lung transplant recipients were evaluated for small molecules using ESI-TOF mass spectrometry and correlated to the development of bronchiolitis obliterans syndrome...
2014: PloS One
Tamim M Nazif, Roxana Mehran, Edwin A M Lee, Martin Fahy, Helen Parise, Gregg W Stone, Ajay J Kirtane
BACKGROUND: Tirofiban and eptifibatide are both small-molecule, competitive glycoprotein IIb/IIIa receptor inhibitors (GPIs) that are guideline-supported for upstream therapy in acute coronary syndromes (ACS). This study sought to compare the efficacy and safety of tirofiban and eptifibatide in patients with ACS. METHODS: Within the ACUITY trial, 4,323 patients with moderate- and high-risk ACS received upstream, adjunctive GPI (tirofiban or eptifibatide) in addition to an antithrombin...
January 2014: American Heart Journal
Bernhard Witzenbichler, Akiko Maehara, Giora Weisz, Franz-Josef Neumann, Michael J Rinaldi, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Bruce R Brodie, Thomas D Stuckey, Ernest L Mazzaferri, Ke Xu, Helen Parise, Roxana Mehran, Gary S Mintz, Gregg W Stone
BACKGROUND: Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. METHODS AND RESULTS: Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents (ADAPT-DES) was a prospective, multicenter, nonrandomized "all-comers" study of 8583 consecutive patients at 11 international centers designed to determine the frequency, timing, and correlates of stent thrombosis and adverse clinical events after DES...
January 28, 2014: Circulation
Deepa Shah, Xiang Qiu, Abhishek Shah, Dianbo Cao
INTRODUCTION: Posterior Nutcracker syndrome (NCS) is a rare anomaly in which the left renal vein passes behind the aorta which compresses it against the vertebral column, restricting the venous drainage of the left kidney. PRESENTATION OF CASE: A 46 year-old lady presented with intermittent painless hematuria for 6 years. Urinalysis showed microscopic hematuria. An abdominal CT scan showed left renal vein duplication with the retroaortic branch trapped between the vertebral column and the aorta at the level of the aortic bifurcation, suggestive of posterior NCS...
2013: International Journal of Surgery Case Reports
Samuel W Reinhardt, Linda X Jin, Susan C Pitt, T Mark Earl, William C Chapman, Majella B Doyle
CASE PRESENTATION: Bouveret's syndrome is a rare variant of gallstone ileus resulting in gastroduodenal obstruction from an impacted gallstone. We report two cases of Bouveret's syndrome that were complicated by classic (distal) gallstone ileus, which has previously been reported only twice. The first patient presented with vomiting, epigastric pain, and what was initially believed to be a duodenal diverticulum on computed tomography scan and endoscopy. He initially improved, but later developed symptoms of a small bowel obstruction...
November 2013: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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