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small stone syndrome

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https://www.readbyqxmd.com/read/28917684/role-of-low-endothelial-shear-stress-and-plaque-characteristics-in-the-prediction-of-nonculprit-major-adverse-cardiac-events-the-prospect-study
#1
Peter H Stone, Akiko Maehara, Ahmet Umit Coskun, Charles C Maynard, Marina Zaromytidou, Gerasimos Siasos, Ioannis Andreou, Dimitris Fotiadis, Kostas Stefanou, Michail Papafaklis, Lampros Michalis, Alexandra J Lansky, Gary S Mintz, Patrick W Serruys, Charles L Feldman, Gregg W Stone
OBJECTIVES: This study sought to determine whether low endothelial shear stress (ESS) adds independent prognostication for future major adverse cardiac events (MACE) in coronary lesions in patients with high-risk acute coronary syndrome (ACS) from the United States and Europe. BACKGROUND: Low ESS is a proinflammatory, proatherogenic stimulus associated with coronary plaque development, progression, and destabilization in human-like animal models and in humans. Previous natural history studies including baseline ESS characterization investigated low-risk patients...
September 18, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28790094/gallstone-ileus-of-the-duodenum-an-unexpected-presentation-of-bouveret-s-syndrome
#2
Neil Tindell, Kayla Holmes, David Marotta
This report describes a patient who presented with a large gallstone obstructing the duodenal bulb, with the chief complaint of acute on chronic abdominal pain. Classically, this is known as Bouveret's syndrome or a gallstone ileus of the duodenum. Our patient's current health status presented a challenge, with the presence of several comorbidities, particularly a large abdominal aortic aneurism. We chose an open procedure for this reason. The stone was removed through a laparotomy, and the cholecystoduodenal fistula that the stone used to pass into the small bowel was repaired...
August 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28588169/outcome-of-surgical-drainage-of-the-pancreatic-duct-in-chronic-pancreatitis
#3
S R Islam, S Rahman, S Rahman, H Kumar, S A Sarkar
Abdominal pain, one of the major symptoms of chronic pancreatitis, is believed to be caused by obstruction of the pancreatic duct system by stones or strictures. This results in increased intraductal pressure and parenchymal ischemia. Surgical decompression of the duct and ductal drainage can achieve best pain relieve and slow the progression of the disease. We want to share our experience of surgical drainage of pancreatic duct in chronic pancreatitis in our hospital. We studied 20 cases operated in our hospital between January 2010 and October 2015...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28229827/anti-la-positive-anti-ro-negative-subset-of-primary-sj%C3%A3-gren-s-syndrome-anti-la-is-a-reality-but-is-the-disease
#4
Debashish Danda, Rohan Sharma, Dat Truong, Kristi A Koelsch, Biji T Kurien, Harini Bagavant, Umesh Deshmukh, C Erick Kaufman, David M Lewis, Donald U Stone, Lida Radfar, Astrid Rasmussen, Kathy L Sivils, Robert H Scofield
OBJECTIVES: To characterise the serological and clinical findings in primary Sjögren's syndrome in which anti-La was found without anti-Ro. We hypothesised that a significant portion of these are falsely negative for anti-Ro60. METHODS: Twenty-nine sera from primary Sjögren's syndrome patients were tested for antibodies directed against La and Ro. Anti-La was detected using bovine La treated with or without DNAase and RNAase to identify potential false positivity...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28221140/-urinary-lithiasis-as-a-systemic-disease
#5
Mercedes Leanez Jiménez, Fernando Candau Vargas-Zúñiga, Carlos Reina Ruiz
Urinary lithiasis is a prevalent disorder of uncertain origin which provokes health problems through potential harm to the urinary system, renal parenchyma or the body as a whole, with a frequent trend to relapse. Historically urinary calculi have been studied and treated as an isolated disease but nowadays we know more about their connection with other pathological entities. In a small percentage of patients, diseases like primary hyperparathyroidism, tubular renal acidosis, inflammatory bowel disease or bariatric surgery have a fairly well studied physiopathological link with kidney stones...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28059621/imaging-of-sialadenitis
#6
Ahmed Abdel Khalek Abdel Razek, Suresh Mukherji
Sialadenitis is an inflammation or infection of the salivary glands that may affect the parotid, submandibular and small salivary glands. Imaging findings vary among unilateral or bilateral salivary gland enlargement, atrophy, abscess, ductal dilation, cysts, stones and calcification. Imaging can detect abscess in acute bacterial suppurative sialadenitis, ductal changes with cysts in chronic adult and juvenile recurrent parotitis. Imaging is sensitive for detection of salivary stones and stricture in obstructive sialadenitis...
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28029221/the-antepartum-stillbirth-syndrome-risk-factors-and-pregnancy-conditions-identified-from-the-intergrowth-21st-project
#7
J E Hirst, J Villar, C G Victora, A T Papageorghiou, D Finkton, F C Barros, M G Gravett, F Giuliani, M Purwar, I O Frederick, R Pang, L Cheikh Ismail, A Lambert, W Stones, Y A Jaffer, D G Altman, J A Noble, E O Ohuma, S H Kennedy, Z A Bhutta
OBJECTIVES: To identify risk factors for antepartum stillbirth, including fetal growth restriction, among women with well-dated pregnancies and access to antenatal care. DESIGN: Population-based, prospective, observational study. SETTING: Eight international urban populations. POPULATION: Pregnant women and their babies enrolled in the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. METHODS: Cox proportional hazard models were used to compare risks among antepartum stillborn and liveborn babies...
December 28, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27541710/gallstones-in-childhood-etiology-clinical-features-and-prognosis
#8
Filiz Serdaroglu, Yavuz S Koca, Fatma Saltik, Tugba Koca, Selim Dereci, Mustafa Akcam, Fusun Z Akcam
AIM: The aim of this study was to determine demographic and clinical features in children diagnosed with gallstones, risk factors for gallstone formation, the effectiveness of ursodeoxycholic acid therapy, and the course of the disease. MATERIALS AND METHODS: Patients aged 0-18 years were followed up for at least 6 months after the diagnosis of gallstones with ultrasonography and were evaluated retrospectively. Patients were evaluated with respect to age, sex, presenting symptoms, BMI, facilitating factors, accompanying diseases, family history of gallstones, history of ceftriaxone use, laboratory tests, ultrasonography findings and follow-up, and therapeutic approaches and results...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27309760/development-of-an-orally-available-and-central-nervous-system-cns-penetrant-toxoplasma-gondii-calcium-dependent-protein-kinase-1-tgcdpk1-inhibitor-with-minimal-human-ether-a-go-go-related-gene-herg-activity-for-the-treatment-of-toxoplasmosis
#9
Rama Subba Rao Vidadala, Kasey L Rivas, Kayode K Ojo, Matthew A Hulverson, Jennifer A Zambriski, Igor Bruzual, Tracey L Schultz, Wenlin Huang, Zhongsheng Zhang, Suzanne Scheele, Amy E DeRocher, Ryan Choi, Lynn K Barrett, Latha Kallur Siddaramaiah, Wim G J Hol, Erkang Fan, Ethan A Merritt, Marilyn Parsons, Gail Freiberg, Kennan Marsh, Dale J Kempf, Vern B Carruthers, Nina Isoherranen, J Stone Doggett, Wesley C Van Voorhis, Dustin J Maly
New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by the protozoan parasite Toxoplasma gondii. To this end, we previously developed a potent and selective inhibitor (compound 1) of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) that possesses antitoxoplasmosis activity in vitro and in vivo. Unfortunately, 1 has potent human ether-a-go-go-related gene (hERG) inhibitory activity, associated with long Q-T syndrome, and consequently presents a cardiotoxicity risk...
July 14, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27086884/definitions-of-intestinal-failure-and-the-short-bowel-syndrome
#10
REVIEW
Loris Pironi
The European Society for Clinical Nutrition and Metabolism defined intestinal failure (IF) as "the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or growth". IF is classified as type 1-acute, type 2-prolonged acute and type 3-chronic IF. A short bowel syndrome (SBS) due to the intestinal malabsorption associated with a functional small intestine length of less than 200 cm is the most frequent mechanism of IF...
April 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/26172166/gall-stone-ileus-own-patients-and-literature-review
#11
REVIEW
Sławomir Kozieł, Piotr Papaj, Katarzyna Dobija-Kubica, Przemysław Śleziński, Józef Wróbel
Cholelithiasis is diagnosed in 10% of the population of the USA and Western Europe. A rare but serious complication of cholelithiasis is the obstruction of the digestive tract caused by a gall-stone (Bernard syndrome). It can add up to 1-4% of the mechanical obstructions of a small intestine among the general population but it can result in nonstriangulational mechanical obstructions of a small intestine in 25% cases among the patients over the age of 65. 5 patients have undergone an operation due to a small intestine gall-stone ileus in years 2011-2013 (within 27 months) in the General Surgery Ward of the Beskid Oncology Center - Municipal Hospital...
May 2015: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/26153549/community-water-fluoridation-and-health-outcomes-in-england-a-cross-sectional-study
#12
Nicholas Young, John Newton, John Morris, Joan Morris, John Langford, Jonathan Iloya, Diane Edwards, Semina Makhani, Julia Verne
BACKGROUND: Six million people in England live in areas where the level of fluoride in water is adjusted to reduce the significant public health burden of dental caries. The dental effects of fluoride are well established, but evidence for suggested adverse health effects is limited, with a lack of rigorous small area population studies that control for confounding. This study aims to test the association between water fluoridation schemes and selected health outcomes using the best available routine data sources...
December 2015: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/26004080/phantom-eye-syndrome-patient-experiences-after-enucleation-for-uveal-melanoma
#13
Laura Hope-Stone, Stephen L Brown, Heinrich Heimann, Bertil Damato, Peter Salmon
PURPOSE: Patients undergoing enucleation for uveal melanoma need to be informed of the possibility of phantom eye syndrome (PES). The number with uveal melanoma in PES studies has been small. Aims were to: (1) determine the prevalence, symptoms, and characteristics of PES and to test associations of PES symptoms with sociodemographic and clinical characteristics; (2) examine the interrelatedness of PES symptoms; and (3) explore the emotional valence of PES and the relationship to anxiety and depression...
August 2015: Ophthalmology
https://www.readbyqxmd.com/read/25554239/low-efficacy-and-high-mortality-associated-with-clofarabine-treatment-of-relapsed-refractory-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#14
MULTICENTER STUDY
Daniel A Roberts, Martha Wadleigh, Anne M McDonnell, Daniel J DeAngelo, Richard M Stone, David P Steensma
Clofarabine, a second-generation nucleoside analog, has clinical activity in relapsed or refractory acute myelogenous leukemia (AML) and higher-risk myelodysplastic syndromes (MDS). However, there are few data evaluating performance of clofarabine in populations of patients not enrolled in clinical trials. We reviewed outcomes for 84 patients treated with clofarabine for relapsed or refractory AML or MDS, either with clofarabine as monotherapy (n=19) or in combination with cytarabine (n=65). Using International Working Group (IWG) response criteria, the overall response rate (ORR) of all treated patients was 21%, with a complete response rate with either complete or incomplete hematopoietic recovery (CRR=CR+CRi) of 14%...
February 2015: Leukemia Research
https://www.readbyqxmd.com/read/25430551/ascaris-lumbricoides-and-its-invasion-of-the-accessory-cystic-duct-an-unusual-presentation
#15
Zain Majid, Irfan Masood, Muhammad Taqi Pirzada
Around the world, Ascaris lumbricoides is the most common helminthic infection. We describe the case of a 25-year-old woman, known to have had Ascaris infestation, presenting with abdominal pain, constipation and jaundice together with fever and tachycardia. There was tenderness in the right hypochondrium and liver function tests confirmed cholestatic jaundice. An abdominal ultrasound showed multiple linear echogenic foci in the distal small intestine along with cholelithiasis and a thick-walled gall bladder with a single stone compressing the common bile duct (Mirizzi syndrome)...
April 2015: Tropical Doctor
https://www.readbyqxmd.com/read/25426732/treating-heart-failure-with-preserved-ejection-fraction-related-to-arterial-stiffness-can-we-kill-two-birds-with-one-stone
#16
REVIEW
Vasilios G Athyros, Efstathios D Pagourelias, Thomas D Gossios, Vasilios G Vasilikos
Heart failure with preserved ejection fraction (HFpEF). Arterial hypertension (AH), arterial stiffness (AS), older age, and female gender are the main determinants of HFpEF, but several cardiac or extra-cardiac pathologies are also possible causes. The combined ventricular-vascular stiffening (abnormal left atrium-left ventricle coupling related to AS) is the main contributor of the increased prevalence of HFpEF in elderly persons, particularly elderly women, and in younger persons with AH. The hospitalization and mortality rates of HFpEF are similar to those of heart failure with reduced EF (HFrEF)...
2015: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/25238733/treatment-of-frontotemporal-dementia
#17
Richard M Tsai, Adam L Boxer
Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative diseases with heterogeneous clinical presentations and two predominant types of underlying neuropathology. FTD typically comprises three distinct clinical syndromes: behavioral variant frontotemporal dementia (bvFTD), semantic variant primary progressive aphasia (svPPA), and nonfluent variant primary progressive aphasia (nfvPPA). FTD also frequently overlaps both clinically and neuropathologically with three other neurodegenerative syndromes: corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)...
November 2014: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/24999535/systemic-inflammatory-response-syndrome-after-flexible-ureteroscopic-lithotripsy-a-study-of-risk-factors
#18
Wen Zhong, Gioacchino Leto, Liang Wang, Guohua Zeng
OBJECTIVE: To evaluate the risk factors for systemic inflammatory response syndrome (SIRS) after flexible ureteroscopic lithotripsy (FUL). MATERIALS AND METHODS: Patients who underwent FUL between October 2012 and November 2013 were studied. Complete data was available for 260 adult patients who met this criteria. Preoperative and intraoperative risk factors that potentially contribute to SIRS were compared in patients who developed postoperative SIRS and those who did not...
January 2015: Journal of Endourology
https://www.readbyqxmd.com/read/24561145/ischemic-outcomes-after-coronary-intervention-of-calcified-vessels-in-acute-coronary-syndromes-pooled-analysis-from-the-horizons-ami-harmonizing-outcomes-with-revascularization-and-stents-in-acute-myocardial-infarction-and-acuity-acute-catheterization-and-urgent
#19
RANDOMIZED CONTROLLED TRIAL
Philippe Généreux, Mahesh V Madhavan, Gary S Mintz, Akiko Maehara, Tullio Palmerini, Laura Lasalle, Ke Xu, Tom McAndrew, Ajay Kirtane, Alexandra J Lansky, Sorin J Brener, Roxana Mehran, Gregg W Stone
OBJECTIVES: This study sought to determine the frequency and impact of coronary calcification among patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS). BACKGROUND: Small studies in patients with stable coronary artery disease have suggested a worse prognosis after PCI of calcified compared with noncalcified lesions. Little is known about the impact of coronary calcification on outcomes after PCI for patients presenting with non-ST-segment elevation and ST-segment elevation ACS...
May 13, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/24552284/early-onset-stroke-and-vasculopathy-associated-with-mutations-in-ada2
#20
Qing Zhou, Dan Yang, Amanda K Ombrello, Andrey V Zavialov, Camilo Toro, Anton V Zavialov, Deborah L Stone, Jae Jin Chae, Sergio D Rosenzweig, Kevin Bishop, Karyl S Barron, Hye Sun Kuehn, Patrycja Hoffmann, Alejandra Negro, Wanxia L Tsai, Edward W Cowen, Wuhong Pei, Joshua D Milner, Christopher Silvin, Theo Heller, David T Chin, Nicholas J Patronas, John S Barber, Chyi-Chia R Lee, Geryl M Wood, Alexander Ling, Susan J Kelly, David E Kleiner, James C Mullikin, Nancy J Ganson, Heidi H Kong, Sophie Hambleton, Fabio Candotti, Martha M Quezado, Katherine R Calvo, Hawwa Alao, Beverly K Barham, Anne Jones, James F Meschia, Bradford B Worrall, Scott E Kasner, Stephen S Rich, Raphaela Goldbach-Mansky, Mario Abinun, Elizabeth Chalom, Alisa C Gotte, Marilynn Punaro, Virginia Pascual, James W Verbsky, Troy R Torgerson, Nora G Singer, Timothy R Gershon, Seza Ozen, Omer Karadag, Thomas A Fleisher, Elaine F Remmers, Shawn M Burgess, Susan L Moir, Massimo Gadina, Raman Sood, Michael S Hershfield, Manfred Boehm, Daniel L Kastner, Ivona Aksentijevich
BACKGROUND: We observed a syndrome of intermittent fevers, early-onset lacunar strokes and other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic vasculopathy in three unrelated patients. We suspected a genetic cause because the disorder presented in early childhood. METHODS: We performed whole-exome sequencing in the initial three patients and their unaffected parents and candidate-gene sequencing in three patients with a similar phenotype, as well as two young siblings with polyarteritis nodosa and one patient with small-vessel vasculitis...
March 6, 2014: New England Journal of Medicine
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