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https://www.readbyqxmd.com/read/29026856/synthesis-and-comparison-of-in-vitro-leishmanicidal-activity-of-5-nitroheteroaryl-1-3-4-thiadiazols-containing-cyclic-amine-of-piperidin-4-ol-at-c-2-with-acyclic-amine-analogues-against-iranian-strain-of-leishmania-major-mrho-ir-75-er
#1
Azar Tahghighi, Alireza Foroumadi, Susan Kabudanian-Ardestani, Seyed Mohammad Amin Mahdian
BACKGROUND: Cutaneous Leishmaniasis (CL) is endemic in many tropical and subtropical regions of the world. Due to the prolonged duration of therapy, adverse effect and resistance to current drugs in the treatment of CL, the discovery of novel, efficient, and safe leishmanicidal drugs is required. The aims of the present study was to synthesis of new compounds based on the active compounds of 5-(5-nitrofuran-2-yl)- and 5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazole bearing the linear amino alcohol of 3-aminopropan-1-ol in the C-2 position of thiadiazole ring and evaluation of their activity against the promastigote and amastigote forms of Leishmania major...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28855945/synthesis-and-antimicrobial-evaluation-of-some-2-5-disubstituted-1-3-4-oxadiazole-derivatives
#2
Elham Jafari, Tahereh Mohammadi, Ali Jahanian-Najafabadi, Farshid Hassanzadeh
1,3,4-oxadiazoles are interesting compounds because of their valuable biological effects such as cytotoxic, antibacterial, antifungal, and anti-tubercular activities. Ethyl mandelate was treated with hydrazine hydrate to yield the corresponding acylhydrazide. Some of the 2,5 disubstituted 1,3,4-oxadiazole derivatives were prepared from acylhydrazide using three different procedures. In the first procedure, acylhydrazide was reacted with nitro or chloro aroyle chloride to afford a diacylhydrazide which was cyclized to 2,5-disubstituted 1,3,4-oxadiazole in the presence of phosphoryl chloride as dehydrating agent...
August 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28832488/committee-opinion-no-717-sulfonamides-nitrofurantoin-and-risk-of-birth-defects
#3
(no author information available yet)
The evidence regarding an association between the nitrofuran and sulfonamide classes of antibiotics and birth defects is mixed. As with all patients, antibiotics should be prescribed for pregnant women only for appropriate indications and for the shortest effective duration. During the second and third trimesters, sulfonamides and nitrofurantoins may continue to be used as first-line agents for the treatment and prevention of urinary tract infections and other infections caused by susceptible organisms. Prescribing sulfonamides or nitrofurantoin in the first trimester is still considered appropriate when no other suitable alternative antibiotics are available...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28832479/committee-opinion-no-717-summary-sulfonamides-nitrofurantoin-and-risk-of-birth-defects
#4
(no author information available yet)
The evidence regarding an association between the nitrofuran and sulfonamide classes of antibiotics and birth defects is mixed. As with all patients, antibiotics should be prescribed for pregnant women only for appropriate indications and for the shortest effective duration. During the second and third trimesters, sulfonamides and nitrofurantoins may continue to be used as first-line agents for the treatment and prevention of urinary tract infections and other infections caused by susceptible organisms. Prescribing sulfonamides or nitrofurantoin in the first trimester is still considered appropriate when no other suitable alternative antibiotics are available...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28738638/mixed-matrix-membranes-incorporated-with-ln-mof-for-selective-and-sensitive-detection-of-nitrofuran-antibiotics-based-on-inner-filter-effect
#5
Feng Zhang, Hua Yao, Yifan Zhao, Xing Li, Gaowei Zhang, Yangyi Yang
The detection of antibiotics is critical and challenging due to the pervasive use of antibiotics had inevitably brought some negative impacts on ecosystem and human health. Herein, we reported an anti-interfere ability enhanced luminescent sensor of lanthanide metal-organic framework (Ln-MOF) filled mixed matrix membranes (MMMs), which combining the processibility of poly(methyl methacrylate) (PMMA) polymer with Ln-MOF of {[Tb2(AIP)2(H2O)10]·(AIP)·4H2O}n (Tb-AIP, where AIP is 5-aminoisophthalate) fillers...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28735057/brazil-s-resolutions-to-regulate-the-sale-of-antibiotics-impact-on-consumption-and-escherichia-coli-resistance-rates
#6
Karen P H Mattos, Marília B Visacri, Júlia C F Quintanilha, Gustavo R Lloret, Maria A Cursino, Anna S Levin, Carlos E Levy, Patricia Moriel
OBJECTIVE: The aim of this study was to determine the impact of two resolutions to restrict antibiotic use (RDCs no. 44/2010 and 20/2011) in the Campinas metropolitan area (Sao Paulo, Brazil) on antibiotic consumption, resistance rates, and trends in Escherichia coli-causing community-acquired urinary tract infection (UTI). METHODS: The annual retail sale information of antibiotics from drugstores in the Campinas metropolitan area between 2008 and 2012 were obtained through the Intercontinental Medical Statistics Health of Brazil...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28637162/response-of-antimicrobial-nitrofurazone-degrading-biocathode-communities-to-different-cathode-potentials
#7
Deyong Kong, Hui Yun, Dan Cui, Mengyuan Qi, Chunyan Shao, Dichen Cui, Nanqi Ren, Bin Liang, Aijie Wang
Bioelectrodegradation of various organic pollutants has been extensively studied. However, whether different cathode potentials could alter the antimicrobial-degrading biocathode community structure and composition remain poorly understood. Here, the microbial community structure and composition of the nitrofurans nitrofurazone (NFZ) degrading biocathode in response to different cathode potentials (-0.45±0.01, -0.65±0.01 and -0.86±0.05V vs standard hydrogen electrode, with applied cell voltages of 0.2, 0...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28600080/novel-pyridyl-nitrofuranyl-isoxazolines-show-antibacterial-activity-against-multiple-drug-resistant-staphylococcus-species
#8
Pietro Picconi, Priya Prabaharan, Jennifer L Auer, Stephanie Sandiford, Francesco Cascio, Madiha Chowdhury, Charlotte Hind, Matthew E Wand, J Mark Sutton, Khondaker M Rahman
A novel series of pyridyl nitrofuranyl isoxazolines were synthesized and evaluated for their antibacterial activity against multiple drug resistant (MDR) Staphylococcus strains. Compounds with piperazine linker between the pyridyl group and isoxazoline ring showed better activity when compared to compounds without the piperazine linker. 3-Pyridyl nitrofuranyl isoxazoline with a piperazine linker was found to be more active than corresponding 2-and 4-pyridyl analogues with MICs in the range of 4-32µg/mL against MDR Staphylococcus strains...
May 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28581742/a-simple-and-fast-extraction-method-for-the-determination-of-multiclass-antibiotics-in-eggs-using-lc-ms-ms
#9
Kun Wang, Kunde Lin, Xinwen Huang, Meng Chen
The purpose of this study was to develop and validate a simple, fast, and specific extraction method for the analysis of 64 antibiotics from nine classes (including sulfonamides, quinolones, tetracyclines, macrolides, lincosamide, nitrofurans, β-lactams, nitromidazoles, and cloramphenicols) in chicken eggs. Briefly, egg samples were simply extracted with a mixture of acetonitrile-water (90:10, v/v) and 0.1 mol·L(-1) Na2EDTA solution assisted with ultrasonic. The extract was centrifuged, condensed, and directly analyzed on a liquid chromatography coupled to tandem mass spectrometry...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28574257/intramolecular-nitrofuran-diels-alder-reactions-extremely-substituent-tolerant-cycloadditions-via-asynchronous-transition-states
#10
Thomas Y Cowie, Marcos Veguillas, Robert L Rae, Mathilde Rougé, Justyna M Żurek, Andrew W Prentice, Martin J Paterson, Magnus W P Bebbington
Nitrofurans undergo intramolecular Diels-Alder reactions with tethered electron-poor dienophiles more rapidly and in higher yield than non-nitrated furans. Computational studies indicate that increased stabilization of a partial positive charge on the nitro-substituted carbon in both transition state and product is the driving force for these reactions. Frontier molecular orbital energy differences indicate a switch from normal to inverse electron demand upon nitration. There does not appear to be a contribution from any differences in aromatic stabilization energy between furans and nitrofurans...
June 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28545445/identification-of-enterococcus-faecalis-enzymes-with-azoreductases-and-or-nitroreductase-activity
#11
Valérie Chalansonnet, Claire Mercier, Sylvain Orenga, Christophe Gilbert
BACKGROUND: Nitroreductases, NAD(P)H dependent flavoenzymes, are found in most of bacterial species. Even if Enterococcus faecalis strains seems to present such activity because of their sensitivity to nitrofurans, no enzyme has been described. Nitroreductases were separated of others reductases due to their capacity to reduce nitro compounds. They are further classified based on their preference in cofactor: NADH and/or NADPH. However, recently, azoreductases have been studied for their strong activity on nitro compounds, especially nitro pro-drugs...
May 25, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28514366/-applicability-of-antibacterial-agents-in-chronic-tonsillitis-treatment
#12
T Yu Vladimirova, L A Barishevskaya, A V Lyamin, O V Kondratenko, A K Velikanov
The purpose of the present study was to evaluate the effectiveness of nitrofuranes applied for the treatment of chronic tonsillitis. A total of 92 subjects divided into three cohorts were involved in this study. Cohort 1 included 43 patients presenting with decompensated chronic tonsillitis and having pathogens in palatine tonsil lacunae. Cohort 2 was comprised of 13 patients with compensated chronic tonsillitis having pathogenic microflora of the same localization, while Cohort 3 was composed of 36 patients resembling those of cohort 1 in terms of clinical presentation, pathogen composition, and microbial spectrum...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28512023/synthesis-and-biological-evaluation-of-novel-5-aryl-4-5-nitrofuran-2-yl-pyrimidines-as-potential-anti-bacterial-agents
#13
Egor V Verbitskiy, Svetlana A Baskakova, Natal'ya A Gerasimova, Natal'ya P Evstigneeva, Natal'ya V Zil'berberg, Nikolay V Kungurov, Marionella A Kravchenko, Sergey N Skornyakov, Marina G Pervova, Gennady L Rusinov, Oleg N Chupakhin, Valery N Charushin
A facile two-step synthetic approach to fluorinated and non-fluorinated 5-aryl-4-(5-nitrofuran-2-yl)-pyrimidines from readily available 5-bromo-4-(furan-2-yl)pyrimidine has been developed. All synthesized compounds were screened in vitro for their antibacterial activities against twelve various bacterial strains. It is demonstrated that some of these compounds exhibited significant antibacterial activities against strains Neisseria gonorrhoeae and Staphylococcus aureus, comparable and even higher with that commercial drug Spectinomycin...
July 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28504818/characterization-of-escherichia-coli-clinical-isolates-causing-urinary-tract-infections-in-the-community-of-chilpancingo-mexico
#14
Jesús A Hernández-Vergara, Verónica I Martínez-Santos, Romina B Radilla-Vázquez, Jesús Silva-Sánchez, Amalia Vences-Velásquez, Natividad Castro-Alarcón
Escherichia coli is the main cause of urinary tract infections (UTI) in ambulatory patients, especially strains belonging to the B2 phylogenetic group and ST131 clonal group. Antibiotic treatment is usually administered empirically; however, it is not always effective due to bacterial multidrug resistance and the production of extended spectrum β-lactamases (ESBLs). The aim of this study was to characterize E. coli clinical isolates from patients with UTI in a community of the State of Guerrero, Mexico. From January to August 2014, 134 clinical isolates of E...
December 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28493683/plant-uptake-and-metabolism-of-nitrofuran-antibiotics-in-spring-onion-grown-in-nitrofuran-contaminated-soil
#15
Yinan Wang, K K Jason Chan, Wan Chan
Environmental pollution caused by the discharge of mutagenic and carcinogenic nitrofurans to the aquatic and soil environment is an emerging public health concern because of the potential in producing drug-resistant microbes and being uptaken by food crops. Using liquid chromatography-tandem mass spectrometry analysis and with spring onion (Allium wakegi Araki) as the plant model, we investigated in this study the plant uptake and accumulation of nitrofuran from a contaminated environment. Our study revealed for the first time high uptake and accumulation rates of nitrofuran in the edible parts of the food crop...
May 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28474416/a-lanthanide-mof-thin-film-fixed-with-co3-o4-nano-anchors-as-a-highly-efficient-luminescent-sensor-for-nitrofuran-antibiotics
#16
Feng Zhang, Hua Yao, Tianshu Chu, Gaowei Zhang, Yi Wang, Yangyi Yang
Nitrofurans are a group of widely used veterinary antibiotics, which have been banned due to antibiotics pollution. Development of a rapid and effective method for the detection of nitrofuran antibiotics (NFAs) is an important challenge. Herein, we designed a chemical sensor based on a thin-film composed of the lanthanide metal-organic framework (Ln-MOF) {[Eu2 (BCA)3 (H2 O)(DMF)3 ]⋅0.5DMF⋅H2 O}n (Eu-BCA, in which BCA is 2,2'-biquinoline-4,4'-dicarboxylate) coated on a cost-effective stainless steel wire mesh (SSWM) by Co3 O4 nano-anchor fixation method...
May 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28411464/development-validation-and-different-approaches-for-the-measurement-uncertainty-of-a-multi-class-veterinary-drugs-residues-lc-ms-method-for-feeds
#17
Andressa Camargo Valese, Luciano Molognoni, Naielly Coelho de Souza, Leandro Antunes de Sá Ploêncio, Ana Carolina Oliveira Costa, Fabiano Barreto, Heitor Daguer
A sensitive method for the simultaneous residues analysis of 62 veterinary drugs in feeds by liquid chromatography-tandem mass spectrometry has been developed and validated in accordance to Commission Decision 657/2002/EC. Additionally, limits of detection (LOD), limits of quantitation (LOQ), matrix effects and measurement uncertainty were also assessed. Extraction was performed for all analytes and respective internal standards in a single step and chromatographic separation was achieved in only 12min. LOQ were set to 0...
May 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28396548/click-chemistry-facilitated-structural-diversification-of-nitrothiazoles-nitrofurans-and-nitropyrroles-enhances-antimicrobial-activity-against-giardia-lamblia
#18
Wan Jung Kim, Keith A Korthals, Suhua Li, Christine Le, Jarosław Kalisiak, K Barry Sharpless, Valery V Fokin, Yukiko Miyamoto, Lars Eckmann
Giardia lamblia is an important and ubiquitous cause of diarrheal disease. The primary agents in the treatment of giardiasis are nitroheterocyclic drugs, particularly the imidazoles metronidazole and tinidazole and the thiazole nitazoxanide. Although these drugs are generally effective, treatment failures occur in up to 20% of cases, and resistance has been demonstrated in vivo and in vitro Prior work had suggested that side chain modifications of the imidazole core can lead to new effective 5-nitroimidazole drugs that can combat nitro drug resistance, but the full potential of nitroheterocycles other than imidazole to yield effective new antigiardial agents has not been explored...
June 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28214232/new-nitrofurans-amenable-by-isocyanide-multicomponent-chemistry-are-active-against-multidrug-resistant-and-poly-resistant-mycobacterium-tuberculosis
#19
Mikhail Krasavin, Vladislav Parchinsky, Grigory Kantin, Olga Manicheva, Marine Dogonadze, Tatiana Vinogradova, Bianka Karge, Mark Brönstrup
A set of structurally diverse N-amino δ-lactams decorated with a 5-nitro-2-furyl moiety was synthesized using isocyanide-based multicomponent chemistry and evaluated for antibacterial activity. Three compounds displayed a selective and potent (MIC 22-33μM) inhibition of M. tuberculosis H37Rv strain growth, while other Gram-positive (MRSA and E. faecium) or Gram-negative (E. coli, P. aeruginosa, A. baumannii, K. pneumoniae) pathogens were not affected. The compounds also displayed moderate-low cytotoxicity, as demonstrated in cell line viability assays...
March 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28187378/development-of-an-analytical-method-for-detecting-nitrofurans-in-bee-pollen-by-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#20
Mi Sun Park, Kyung Tae Kim, Jong Seong Kang
Bee pollen collected by honeybees, which is in powdered form, is a good nutritional supplement. Nitrofuran antibiotics are assumed not to be present in bee pollen, which is important as the level of antibiotics in bee pollen is strongly regulated in many countries. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect nitrofurans in honey has been developed, but this method is not suitable for bee pollen because of it being in powdered form. During preparation of bee pollen samples, the dispersal of powder particles in an aqueous solution often makes them susceptible to forming an emulsion with solvent components such as hexane and ethyl acetate...
March 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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