Maytham Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Louise M Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G Rao, Jian Li, Kathryn E Holt, Tony Velkov
A quest for novel antibiotics and revitalizing older ones (such as nitrofurantoin) for treatment of difficult-to-treat Gram-negative bacterial infections has become increasingly popular. The precise antibacterial activity of nitrofurantoin is still not fully understood. Furthermore, although the prevalence of nitrofurantoin resistance remains low currently, the drug's fast-growing consumption worldwide highlights the need to comprehend the emerging resistance mechanisms. Here, we used multidisciplinary techniques to discern the exact mechanism of nitrofurantoin action and high-level resistance in Klebsiella pneumoniae , a common cause of urinary tract infections for which nitrofurantoin is the recommended treatment...
December 11, 2023: MSystems