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https://www.readbyqxmd.com/read/28411464/development-validation-and-different-approaches-for-the-measurement-uncertainty-of-a-multi-class-veterinary-drugs-residues-lc-ms-method-for-feeds
#1
Andressa Camargo Valese, Luciano Molognoni, Naielly Coelho de Souza, Leandro Antunes de Sá Ploêncio, Ana Carolina Oliveira Costa, Fabiano Barreto, Heitor Daguer
A sensitive method for the simultaneous residues analysis of 62 veterinary drugs in feeds by liquid chromatography-tandem mass spectrometry has been developed and validated in accordance to Commission Decision 657/2002/EC. Additionally, limits of detection (LOD), limits of quantitation (LOQ), matrix effects and measurement uncertainty were also assessed. Extraction was performed for all analytes and respective internal standards in a single step and chromatographic separation was achieved in only 12min. LOQ were set to 0...
March 25, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28396548/click-chemistry-facilitated-structural-diversification-of-nitrothiazoles-nitrofurans-and-nitropyrroles-enhances-antimicrobial-activity-against-giardia-lamblia
#2
Wan Jung Kim, Keith Korthals, Suhua Li, Christine Le, Jaroslaw Kalisiak, K Barry Sharpless, Valery V Fokin, Yukiko Miyamoto, Lars Eckmann
Giardia lamblia is an important and ubiquitous cause of diarrheal disease. The primary agents in the treatment of giardiasis are nitroheterocyclic drugs, particularly the imidazoles metronidazole and tinidazole, and the thiazole, nitazoxanide. Although these drugs are generally effective, treatment failures occur in up to 20% of cases and resistance has been demonstrated in vivo and in vitro. Prior work had suggested that side chain modifications of the imidazole core can lead to effective new 5-nitroimidazole drugs that can combat nitro drug resistance, but the full potential of nitroheterocycles other than imidazole to yield effective new antigiardial agents has not been explored...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28214232/new-nitrofurans-amenable-by-isocyanide-multicomponent-chemistry-are-active-against-multidrug-resistant-and-poly-resistant-mycobacterium-tuberculosis
#3
Mikhail Krasavin, Vladislav Parchinsky, Grigory Kantin, Olga Manicheva, Marine Dogonadze, Tatiana Vinogradova, Bianka Karge, Mark Brönstrup
A set of structurally diverse N-amino δ-lactams decorated with a 5-nitro-2-furyl moiety was synthesized using isocyanide-based multicomponent chemistry and evaluated for antibacterial activity. Three compounds displayed a selective and potent (MIC 22-33μM) inhibition of M. tuberculosis H37Rv strain growth, while other Gram-positive (MRSA and E. faecium) or Gram-negative (E. coli, P. aeruginosa, A. baumannii, K. pneumoniae) pathogens were not affected. The compounds also displayed moderate-low cytotoxicity, as demonstrated in cell line viability assays...
February 4, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28187378/development-of-an-analytical-method-for-detecting-nitrofurans-in-bee-pollen-by-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#4
Mi Sun Park, Kyung Tae Kim, Jong Seong Kang
Bee pollen collected by honeybees, which is in powdered form, is a good nutritional supplement. Nitrofuran antibiotics are assumed not to be present in bee pollen, which is important as the level of antibiotics in bee pollen is strongly regulated in many countries. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect nitrofurans in honey has been developed, but this method is not suitable for bee pollen because of it being in powdered form. During preparation of bee pollen samples, the dispersal of powder particles in an aqueous solution often makes them susceptible to forming an emulsion with solvent components such as hexane and ethyl acetate...
January 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28185724/simplifying-nature-towards-the-design-of-broad-spectrum-kinetoplastid-inhibitors-inspired-by-acetogenins
#5
Eoin R Gould, Elizabeth F B King, Stefanie K Menzies, Andrew L Fraser, Lindsay B Tulloch, Marija K Zacharova, Terry K Smith, Gordon J Florence
The need for new treatments for the neglected tropical diseases African sleeping sickness, Chagas disease and Leishmaniasis remains urgent with the diseases widespread in tropical regions, affecting the world's very poorest. We have previously reported bis-tetrahydropyran 1,4-triazole analogues designed as mimics of the annonaceous acetogenin natural product chamuvarinin, which maintained trypanocidal activity. Building upon these studies, we here report related triazole compounds with pendant heterocycles, mimicking the original butenolide of the natural product...
January 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28149295/marine-bivalve-mollusks-as-possible-indicators-of-multidrug-resistant-escherichia-coli-and-other-species-of-the-enterobacteriaceae-family
#6
Didrik H Grevskott, Cecilie S Svanevik, Marianne Sunde, Astrid L Wester, Bjørn T Lunestad
The mechanisms for the development and spread of antibacterial resistance (ABR) in bacteria residing in environmental compartments, including the marine environment, are far from understood. The objective of this study was to examine the ABR rates in Escherichia coli and other Enterobacteriaceae isolates obtained from marine bivalve mollusks collected along the Norwegian coast during a period from October 2014 to November 2015. A total of 549 bivalve samples were examined by a five times three tube most probable number method for enumeration of E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28092859/n-2-arylmethylimino-ethyl-7-chloroquinolin-4-amine-derivatives-synthesized-by-thermal-and-ultrasonic-means-are-endowed-with-anti-zika-virus-activity
#7
Giselle Barbosa-Lima, Ligia S da Silveira Pinto, Carlos R Kaiser, James L Wardell, Caroline S De Freitas, Yasmine R Vieira, Andressa Marttorelli, José Cerbino Neto, Patrícia T Bozza, Solange M S V Wardell, Marcus V N de Souza, Thiago M L Souza
Zika virus (ZIKV), an emerging Flavivirus, was recently associated with severe neurological complications and congenital diseases. Therefore, development of antiviral agents capable of inhibiting ZIKV replication is urgent. Chloroquine is a molecule with a confirmed safety history for use with pregnant women, and has been found to exhibit anti-ZIKV activity at concentrations around 10 μM. This suggests that modifications to the chloroquine structure could be promising for obtaining more effective anti-ZIKV agents...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28077022/feasibility-of-a-novel-multispot-nanoarray-for-antibiotic-screening-in-honey
#8
Sara E McNamee, Giulia Rosar, Lidija Persic, Christopher T Elliott, Katrina Campbell
Practical solutions for multiple antibiotic determination in food are required by the food industry and regulators for cost-effective screening purposes. This study describes the feasibility in development and preliminary performance of a novel multispot nanoarray for antibiotic screening in honey. Using a multiplex approach, the metabolites of the four main nitrofuran antibiotics, including morpholinomethyl-2-oxazolidone (AMOZ), 3-amino-2-oxazolidinone (AOZ), semicarbazide (SEM), 1-aminohydantoin (AHD) and chloramphenicol (CAP), were simultaneously detected...
April 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28009105/prevalence-and-antimicrobial-resistance-of-salmonella-enterica-serovar-indiana-in-china-1984-2016
#9
REVIEW
J Gong, P Kelly, C Wang
Salmonella enterica serovar Indiana, first described in 1955, is generally regarded as having a low frequency worldwide with outbreaks of gastroenteritis and abortions described in North America and Europe. In China, S. Indiana was first reported in 1984 and in the subsequent 71 surveys in 35 cities/municipalities from 18 provinces, 70% of which were after 2012, S. Indiana has been shown to have become widely prevalent in people, animals, food and the environment around abattoirs and meat processing facilities...
December 23, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28007448/bioreductively-activatable-prodrug-conjugates-of-phenstatin-designed-to-target-tumor-hypoxia
#10
Blake A Winn, Zhe Shi, Graham J Carlson, Yifan Wang, Benson L Nguyen, Evan M Kelly, R David Ross, Ernest Hamel, David J Chaplin, Mary L Trawick, Kevin G Pinney
A variety of solid tumor cancers contain significant regions of hypoxia, which provide unique challenges for targeting by potent anticancer agents. Bioreductively activatable prodrug conjugates (BAPCs) represent a promising strategy for therapeutic intervention. BAPCs are designed to be biologically inert until they come into contact with low oxygen tension, at which point reductase enzyme mediated cleavage releases the parent anticancer agent in a tumor-specific manner. Phenstatin is a potent inhibitor of tubulin polymerization, mimicking the chemical structure and biological activity of the natural product combretastatin A-4...
February 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27988333/delamanid-is-not-metabolized-by-salmonella-or-human-nitroreductases-a-possible-mechanism-for-the-lack-of-mutagenicity
#11
COMPARATIVE STUDY
Erina Hanaki, Mikayo Hayashi, Makoto Matsumoto
Nitro-containing compounds such as nitrofuran and nitroimidazole are drugs used for the treatment of infectious diseases. However, many of these nitro-containing drugs are positive in the bacterial reverse mutation assay (Ames test). The recently approved anti-multidrug-resistant tuberculosis (MDR-TB) drug, delamanid (Deltyba™; OPC-67683), a derivative of 4-nitroimidazole, was negative for mutagenicity in the Ames assay. In Salmonella typhimurium, mutagenicity of nitro compounds has been closely associated with the ability of nitroreductase to metabolize (degradation)these compounds...
March 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27979167/simultaneous-detection-of-four-nitrofuran-metabolites-in-honey-by-using-a-visualized-microarray-screen-assay
#12
Zhonghui Li, Zhoumin Li, Danke Xu
A visualized microarray sensing technique has been developed and applied to the screening of honey samples for residues of banned nitrofuran antibiotics. Using a multiplexed approach, metabolites of four main nitrofuran antibiotics can be detected simultaneously. Individual antigens were spotted onto 96-well plates. An indirective competitive assay format, with visualized signal response, was employed. An extraction method, based on derivatization with 2-nitrobenzaldehyde and partition into ethyl acetate, was used for screening...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27934822/distribution-of-virulence-determinants-among-antimicrobial-resistant-and-antimicrobial-susceptible-escherichia-coli-implicated-in-urinary-tract-infections
#13
Sam Stephenson, P D Brown
INTRODUCTION: Uropathogenic Escherichia coli (UPEC) rely on the correlation of virulence expression with antimicrobial resistance to persist and cause severe urinary tract infections (UTIs). OBJECTIVES: We assessed the virulence pattern and prevalence among UPEC strains susceptible and resistant to multiple antimicrobial classes. METHODS: A total of 174 non-duplicate UPEC strains from patients with clinically significant UTIs were analysed for susceptibility to aminoglycoside, antifolate, cephalosporin, nitrofuran and quinolone antibiotics for the production of extended-spectrum β-lactamases and for the presence of six virulence determinants encoding adhesins (afimbrial, Type 1 fimbriae, P and S-fimbriae) and toxins (cytotoxic necrotising factor and haemolysin)...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902285/raineyella-antarctica-gen-nov-sp-nov-a-psychrotolerant-d-amino-acid-utilizing-anaerobe-isolated-from-two-geographic-locations-of-the-southern-hemisphere
#14
Elena Vladimirovna Pikuta, Rodolfo Javier Menes, Alisa Michelle Bruce, Zhe Lyu, Nisha B Patel, Yuchen Liu, Richard Brice Hoover, Hans-Jürgen Busse, Paul Alexander Lawson, William Barney Whitman
A Gram-stain-positive bacterium, strain LZ-22T, was isolated from a rhizosphere of moss Leptobryum sp. collected at the shore of Lake Zub in Antarctica. Cells were motile, straight or pleomorphic rods with sizes of 0.6-1.0×3.5-10 µm. The novel isolate was a facultatively anaerobic, catalase-positive, psychrotolerant mesophile. Growth was observed at 3-41 °C (optimum 24-28 °C), with 0-7 % (w/v) NaCl (optimum 0.25 %) and at pH 4.0-9.0 (optimum pH 7.8). The quinone system of strain LZ-22T possessed predominately menaquinone MK-9(H4)...
December 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27810595/rational-design-of-nitrofuran-derivatives-synthesis-and-valuation-as-inhibitors-of-trypanosoma-cruzi-trypanothione-reductase
#15
D G Arias, F E Herrera, A S Garay, D Rodrigues, P S Forastieri, L E Luna, M D L M Bürgi, C Prieto, A A Iglesias, R M Cravero, S A Guerrero
The rational design and synthesis of a series of 5-nitro-2-furoic acid analogues are presented. The trypanocidal activity against epimastigote forms of Trypanosoma cruzi and the toxic effects on human HeLa cells were tested. Between all synthetic compounds, three of thirteen had an IC50 value in the range of Nfx, but compound 13 exhibited an improved effect with an IC50 of 1.0 ± 0.1 μM and a selective index of 70 in its toxicity against HeLa cells. We analyzed the activity of compounds 8, 12 and 13 to interfere in the central redox metabolic pathway in trypanosomatids, which is dependent of reduced trypanothione as the major pivotal thiol...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27748168/occurrence-and-levels-of-nitrofuran-metabolites-in-sea-cucumber-from-dalian-china
#16
Hongxia Zhao, Wuxia Guo, Wenna Quan, Jingqiu Jiang, Baocheng Qu
The occurrence and levels of nitrofuran metabolites (NFMs) in sea cucumber (SC) from Dalian, China, are reported. Four metabolites including 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), 3-amino-2-oxazolidinone (AOZ), semicarbazide (SEM) and 1-aminohydantoin (AHD) in different SC products (fresh, instant and dry salted SCs) were measured. The frequency of occurrence for NFMs in all SC samples was 42.7%. The total NFM concentrations ranged from non-detectable to 64.6 ng g(-)(1), with a mean of 3.59 ng g(-1)...
November 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27664624/multi-class-method-for-the-determination-of-nitroimidazoles-nitrofurans-and-chloramphenicol-in-chicken-muscle-and-egg-by-dispersive-solid-phase-extraction-and-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry
#17
Zhiwen Zhang, Yuping Wu, Xiaowei Li, Yingyu Wang, Hui Li, Qin Fu, Yawen Shan, Tianhe Liu, Xi Xia
This study describes the development of a multiresidue method for the efficient identification and quantification of nitroimidazoles, nitrofurans, and chloramphenicol in chicken and egg. After derivatization of nitrofuran metabolites, dispersive-solid phase extraction was used for the extraction of target analytes. An optimization strategy involved the selection of sorbents and extraction solutions for dispersive-solid phase extraction in order to achieve acceptably high recoveries and reduce co-extractives in the final extracts...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27612928/analysis-of-banned-veterinary-drugs-and-herbicide-residues-in-shellfish-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms-and-gas-chromatography-tandem-mass-spectrometry-gc-ms-ms
#18
Geng-Ruei Chang, Hui-Shan Chen, Feng-Yi Lin
Seafood safety is a crucial public health concern for consumers. In this study, we applied a validated method to analyze the residue of banned veterinary drugs in shellfish, namely chloramphenicol, malachite green, leucomalachite green, and nitrofuran metabolites; additionally, the QuEChERS method was employed to detect 76 herbicides by LC/MS/MS and GC/MS/MS. In total, 42 shellfish samples, which included hard clams, freshwater clams, and oysters, were collected from aquafarms and production areas in Taiwan during 2012...
December 15, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27600051/disruption-of-membrane-by-colistin-kills-uropathogenic-escherichia-coli-persisters-and-enhances-killing-of-other-antibiotics
#19
Peng Cui, Hongxia Niu, Wanliang Shi, Shuo Zhang, Hao Zhang, Joseph Margolick, Wenhong Zhang, Ying Zhang
Persisters are small populations of quiescent bacterial cells that survive exposure to bactericidal antibiotics and are responsible for many persistent infections and posttreatment relapses. However, little is known about how to effectively kill persister bacteria. In the work presented here, we found that colistin, a membrane-active antibiotic, was highly active against Escherichia coli persisters at high concentrations (25 or 50 μg/ml). At a clinically relevant lower concentration (10 μg/ml), colistin alone had no apparent effect on E...
November 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27556439/curcumin-ameliorates-furazolidone-induced-dna-damage-and-apoptosis-in-human-hepatocyte-l02-cells-by-inhibiting-ros-production-and-mitochondrial-pathway
#20
Chongshan Dai, Daowen Li, Lijing Gong, Xilong Xiao, Shusheng Tang
Furazolidone (FZD), a synthetic nitrofuran derivative, has been widely used as an antibacterial and antiprotozoal agent. Recently, the potential toxicity of FZD has raised concerns, but its mechanism is still unclear. This study aimed to investigate the protective effect of curcumin on FZD-induced cytotoxicity and the underlying mechanism in human hepatocyte L02 cells. The results showed that curcumin pre-treatment significantly ameliorated FZD-induced oxidative stress, characterized by decreased reactive oxygen species (ROS) and malondialdehyde formation, and increased superoxide dismutase, catalase activities and glutathione contents...
August 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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