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Apotosis

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https://www.readbyqxmd.com/read/29733976/ebselen-protects-mitochondrial-function-and-oxidative-stress-while-inhibiting-the-mitochondrial-apoptosis-pathway-after-acute-spinal-cord-injury
#1
Zhi-Qiang Jia, San-Qiang Li, Wei-Qiang Qiao, Wen-Zhong Xu, Jian-Wu Xing, Jian-Tao Liu, Hui Song, Zhong-Yang Gao, Bing-Wen Xing, Xi-Jing He
Ebselen is a fat-soluble small molecule and organic selenium compound that regulates the activity of glutathione peroxidase to alleviate mitochondrial oxidative stress and improve mitochondrial function. In the present study, we aimed to investigate the effects of ebselen on mitochondrial oxidative stress response, mitochondrial apotosis, and motor behaviors after spinal cord injury (SCI). We found that ebselen significantly increased the BBB score in motor behavior, thus suggesting a rescue effect of ebselen on motor function after SCI in rats...
May 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29715117/micropapillary-structures-in-colorectal-cancer-an-anoikis-resistant-subpopulation
#2
Madhura Patankar, Sara Väyrynen, Anne Tuomisto, Markus Mäkinen, Sinikka Eskelinen, Tuomo J Karttunen
BACKGROUND/AIM: Micropapillary structures (MIPs) are focal piles of columnar cells without extracellular matrix contact, and common in serrated colorectal carcinoma (CRC). In order to characterize biology of MIPs in colorectal cancer (CRC), the proliferation and apoptosis rates, and survivin expression were compared between MIPs and other cancer epithelial cells of CRC (non-MIPs). MATERIALS AND METHODS: We assessed 46 samples of normal colorectal mucosa, 62 carcinomas and 54 polyps for proliferation (Ki67), apoptosis (M30), and survivin expression by immunohistochemistry...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29625110/lncrna-tp73-as1-predicts-the-prognosis-of-bladder-cancer-patients-and-functions-as-a-suppressor-for-bladder-cancer-by-emt-pathway
#3
Zhiyong Tuo, Jianbin Zhang, Wei Xue
Long noncoding RNAs (lncRNAs) have been identified to have more and more important roles in tumorigenesis and may be novel biomarker for cancer therapy. LncRNA TP73-AS1 is a novel identified lncRNA that has been demonstrated to be increased in several cancers, however, its function in bladder cancer remains unknown. The aim of this work was to examine the expression and role of lncRNA TP73-AS1 in bladder cancer. The expression levels of lncRNA TP73-AS1 in bladder cancer tissues and cell lines were determined by quantitative real-time PCR (qRT-PCR), and its clinical significance was assessed by statistical analysis...
May 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29528563/effect-of-cdmem-media-containing-ectoine-on-human-periodontal-ligament-mesenchymal-stem-cell-survival-and-differentiation
#4
Damla Tuncer Budanur, Noushin Zibandeh, Deniz Genç, Muazzez Gökalp, Kamber Kaşali, Tunç Akkoç, Elif Sepet
BACKGROUND/AIM: Ectoine is an amino acid that can preserve osmotic balance and has more preservative activity than other osmoregulators. There are no published reports on the osmoregulators' effects on viability or differentiation of dental stem cells. The aim of this study was to investigate the effect of Ectoine as a storage media on the viability and differentiation potential of human periodontal ligament mesenchymal stem cells (hPDLMSCs). MATERIALS AND METHODS: hPDLMSCs were obtained from impacted third molar teeth...
March 12, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29503967/improvements-of-visual-function-and-outer-retinal-morphology-following-spontaneous-regression-of-cancer-in-anti-recoverin-cancer-associated-retinopathy
#5
Yuka Suimon, Wataru Saito, Kiriko Hirooka, Atsuhiro Kanda, Hidenori Kitai, Jun Sakakibara-Konishi, Susumu Ishida
Purpose: To report an anti-recoverin antibody-positive cancer-associated retinopathy (anti-recoverin CAR) patient with remarkable improvements of visual function and outer retinal morphology following spontaneous regression of cancer. Observations: A 65-year-old woman with small cell lung carcinoma developed progressive, bilateral vision loss with diffuse loss of the ellipsoid zone at the macula on optical coherence tomography and marked reduced responses of a- and b-waves on electroretinography...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29289998/molecular-signature-of-nitric-oxide-on-major-cancer-hallmarks-of-colorectal-carcinoma
#6
REVIEW
Paramita Mandal
Colorectal cancer (CRC) is the one of the most important diseases throughout the world. Several aetiological risk factors, viz. sedentary life style, smoking, alcohol intake, less physical activity, red meat, and microbiota, are associated with the development of CRC. Molecular pathophysiology of CRC implies inflammation, metastasis, apotosis and angiogenesis. Inflammation involves interaction between various immune cells, inflammatory cells, chemokines, cytokines, and pro-inflammatory mediators, such as cyclooxygenase (COX) and lipoxygenase (LOX) pathways, which may lead to signalling towards, tumour cell proliferation, growth, and invasion whereas nitric oxide (NO) has been associated with metastasis, apoptosis, and angiogenesis...
April 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29278758/leucine-reduces-the-proliferation-of-mc3t3-e1-cells-through-dna-damage-and-cell-senescence
#7
Raquel da Luz Dias, Bruno Basso, Márcio Vinícius Fagundes Donadio, Francesc Ventura Pujol, Ramón Bartrons, Gabriela Viegas Haute, Rodrigo Benedetti Gassen, Henrique Dias Bregolin, Gabriele Krause, Cassiana Viau, Jenifer Saffi, Fernanda Bordignon Nunes, José Luis Rosa, Jarbas Rodrigues de Oliveira
Leucine (Leu) is an essential branched-chain amino acid, present in dairy products, which has been investigated for its important role in cell signaling. The effects of Leu on several kinds of cells have been studied, altough little is known on its action upon bone cells and cell proliferation. Thus, the aim of this study is to investigate the effects of Leu supplementation on the proliferation of pre-osteoblasts from MC3T3-E1 lineage. MC3T3-E1 cells were kept in Alpha medium supplemented with 10% fetal bovine serum and 1% antibiotic-antimitotic...
April 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29057216/contribution-of-in-vivo-experimental-challenges-to-understanding-flat-oyster-ostrea-edulis-resistance-to-bonamia-ostreae
#8
Benjamin Morga, Tristan Renault, Nicole Faury, Sophie Lerond, Céline Garcia, Bruno Chollet, Jean-Pierre Joly, Sylvie Lapègue, Estelle Harrang, Isabelle Arzul
Bonamiosis due to the parasite Bonamia ostreae has been associated with massive mortality outbreaks in European flat oyster stocks in Europe. As eradication and treatment are not possible, the control of the disease mainly relies on transfer restriction. Moreover, selection has been applied to produce resistant flat oyster families, which present better survival and lower prevalence than non-selected oysters. In order to better understand the mechanisms involved in resistance to bonamiosis, cellular and molecular responses of 2 oyster groups (selected oysters and wild-type oysters) were analyzed in the context of experimental injection and cohabitation infections...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28960861/lentivirus-mediated-disintegrin-and-metalloproteinase-17-rna-interference-reversed-the-acquired-resistance-to-gefitinib-in-lung-adenocarcinoma-cells-in-vitro
#9
Ya-Qing Li, Yuan-Shun Liu, Xi-Wang Ying, Hong-Bin Zhou, Zhehua Wang, Sheng-Chang Wu, Jian-Ping Yan, Yu-Ting Jing, Yang Yang
OBJECTIVE: The aim of the study is to evaluate the effects of silencing a disintegrin and metalloproteinase 17 (ADAM17) gene expression by lentivirus-mediated RNA interference (RNAi) in the gefitinib-resistant lung adenocarcinoma cells, and then to explore whether the recombinant lentivirus mediated ADAM17 RNAi reversed the acquired resistance of lung adenocarcinoma to gefitinib in vitro. METHODS: The gefitinib-resistant RPC-9 cells were established and the mutations of EGFR were detected by gene sequencing...
January 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/28883899/caffeic-acid-phenethyl-ester-reduces-ischemia-induced-kidney-mitochondrial-injury-in-rats
#10
Sonata Trumbeckaite, Neringa Pauziene, Darius Trumbeckas, Mindaugas Jievaltas, Rasa Baniene
During partial nephrectomy, the avoidance of ischemic renal damage is extremely important as duration of renal artery clamping (i.e., ischemia) influences postoperative kidney function. Mitochondria (main producer of ATP in the cell) are very sensitive to ischemia and undergo damage during oxidative stress. Finding of a compound which diminishes ischemic injury to kidney is of great importance. Caffeic acid phenethyl ester (CAPE), biologically active compound of propolis, might be one of the promising therapeutic agents against ischemia-caused damage...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28688122/diminazene-aceturate-prevents-nephropathy-by-increasing-glomerular-ace2-and-at2-receptor-expression-in-a-rat-model-of-type1-diabetes
#11
Santosh Kumar Goru, Almesh Kadakol, Vajir Malek, Anuradha Pandey, Nisha Sharma, Anil Bhanudas Gaikwad
BACKGROUND AND PURPOSE: One of the protective actions of angiotensin converting enzyme-2 (ACE2) is the inactivation of angiotensin II. Expression and activity of ACE2 was reduced in glomeruli of diabetic patients and in animal models of diabetes. Recently the potential role of recombinant ACE2 administration in preventing diabetic nephropathy (DN) has been shown. Here we have tested the effects of the ACE2 activator, diminazene aceturate (DIZE), in a model of DN. EXPERIMENTAL APPROACH: Male Wistar rats were rendered diabetic using a single dose of streptozotocin (55 mg·kg(-1) , i...
September 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28646900/human-umbilical-cord-stem-cell-conditioned-medium-versus-serum-free-culture-medium-in-the-treatment-of-cryopreserved-human-ovarian-tissues-in-in-vitro-culture-a-randomized-controlled-trial
#12
Yingxian Jia, Xiaohan Shi, Yidong Xie, Xiaochuan Xie, Yan Wang, Shangwei Li
BACKGROUND: To reduce young female fertility loss, the in-vitro culture of cryopreserved ovarian cortical tissues (OCTs) is considered an effective approach without delaying treatment and undergoing stimulation medicine. However, ischemic damage and follicular loss during the in-vitro culture of OCTs are major technical challenges. Human umbilical cord stem cells (HUMSCs) and their conditioned medium (HUMSC-CM) have been considered to be potential resources for regeneration medicine because they secrete cytokines and enhance cell survival and function...
June 24, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28638452/targeting-tpx2-suppresses-the-tumorigenesis-of-hepatocellular-carcinoma-cells-resulting-in-arrested-mitotic-phase-progression-and-increased-genomic-instability
#13
Chao-Wen Hsu, Yu-Chia Chen, Hsing-Hao Su, Guan-Jin Huang, Chih-Wen Shu, Tony Tong-Lin Wu, Hung-Wei Pan
Hepatocellular carcinoma (HCC) remains one of the most difficult cancers to treat, with chemotherapies being relatively ineffective. Therefore, a better knowledge of molecular hepatocarcinogenesis will provide opportunities for designing targeted therapies. TPX2 (targeting protein for Xklp2) is overexpressed as a consequence of oncogenic alterations and is likely to alter the proper regulation of chromosome segregation in cancer cells. Disrupting the machinery which is responsible for mitosis and chromosome instability in cancer cells can be one of the most successful strategies for cancer therapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28425856/apicidin-inhibited-proliferation-and-invasion-and-induced-apoptosis-via-mitochondrial-pathway-in-non-small-cell-lung-cancer-glc-82-cells
#14
Jianye Zhang, Zhenzhu Lai, Wenjing Huang, Huiping Ling, Minting Lin, Sili Tang, Yun Liu, Yiwen Tao
BACKGROUND: Apicidin, as an inhibitor of histone deacetylase, showed a wide range of antiproliferative activity against various cancer cell lines. Apicidin has also been reported to induce apotosis via Fas/Fas ligand. Yet few studies have been focused on mitochondrial pathway for its anti-tumor activity. OBJECTIVE: In this study, we evaluated its involved mitochondrial mechanism against non-small cell lung cancer GLC-82 cells. METHOD: Apicidin was isolated from the mangrove endophtic fungi Fusarium sp...
2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28366952/oxidative-stress-and-apotosis-to-zebrafish-danio-rerio-embryos-exposed-to-perfluorooctane-sulfonate-pfos-and-zno-nanoparticles
#15
Jia Du, Jun Cai, Shutao Wang, Hong You
OBJECTIVES: Perfluorooctane sulfonate (PFOS) and zinc oxide nanoparticles (ZnO-NPs) are frequently detected in the environment but few studies have assessed the joint toxicity of them. Oxidative stress and apoptosis to zebrafish (Danio rerio) embryos induced by the PFOS and ZnO-NPs were investigated in this study. MATERIAL AND METHODS: The embryos were exposed to the PFOS (0, 0.4, 0.8 and 1.6 mg/l), ZnO-NPs (12.5, 25, 50 mg/l) and PFOS plus ZnO-NPs (0.4+12.5, 0...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28363843/toll-like-receptor-9-mediates-paraquat-induced-acute-lung-injury-an-in-vitro-and-in-vivo-study
#16
Haitao Shen, Na Wu, Yu Wang, Lichun Zhang, Xiao Hu, Zhiguang Chen, Min Zhao
AIMS: This study aimed to investigate the role of Toll-like receptor 9 in paraquat-induced acute lung injury (ALI). MAIN METHODS: For in vivo study,C57BL mice were randomly assigned into the vehicle control group, paraquat group, paraquat + TLR9 antagonist (ODN2088) group, and TLR9 antagonist (ODN2088) group (n=36 per group). After paraquat 30mg/kg ip for 2, 24 and 48h, serum samples and lung tissues were collected to evaluate ALI and TLR9 signaling by lung injury score, protein levels of TLR9, MyD88, p-IRAK4, p-p65, and serum TNF-α and IL-1β levels...
June 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28245381/-effect-of-arsenic-trioxide-on-k562-cell-proliferation-and-its-mechanism
#17
Yuan Wang, Jie Yang, Jie Li, Rui-Cang Wang, Jun Yuan, Yan Li, Su-Yun Wang, Chao Wang, Hong-Ling Hao
OBJECTIVE: To investigate the molecular mechanism of arsenic trioxide(ATO) inhibiting K562 cell proliferation, and explore the new targets for treating chronic myeloid leukemia(CML). METHODS: human CML cell line K562 cells were cultured in vitro, and were treated with different concentrations of ATO; MTT was used to detect the cell proliferation; flow cytometry(FCM) was used to determine cell apoptosis, cell cycle and the expression of CD44; Transcriptional levels of β-catenin and cyclin D1 were assayed by RT-PCR...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28196286/psoralen-with-ultraviolet-a-induced-apoptosis-of-cutaneous-lymphoma-cell-lines-is-augmented-by-type-i-interferons-via-the-jak1-stat1-pathway
#18
Walter Liszewski, David Gram Naym, Edyta Biskup, Robert Gniadecki
BACKGROUND: Photochemotherapy with psoralen and ultraviolet A (PUVA), with or without adjuvant interferon-α (IFN-α), is a first-line therapy for early-stage mycosis fungoides and other forms of cutaneous T-cell lymphoma (CTCL). However, the mechanism by which PUVA with IFN-α work in CTCL is poorly understood. PURPOSE: To develop a model to investigate the mechanisms of PUVA and PUVA with IFN-α in CTCL cells. METHODS: An in vitro model to study the molecular mechanisms of PUVA was created using two different CTCL cell lines, MyLa, which has functional p53, and HuT-78, in which p53 is inactivated due to a homozygous nonsense mutation...
May 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28181540/hiv-related-proteins-prolong-macrophage-survival-through-induction-of-triggering-receptor-expressed-on-myeloid-cells-1
#19
Zhihong Yuan, Xian Fan, Bashar Staitieh, Chetna Bedi, Paul Spearman, David M Guidot, Ruxana T Sadikot
Triggering receptor expressed on myeloid cells-1(TREM-1) is a member of the superimmunoglobulin receptor family. We have previously shown that TREM-1 prolongs survival of macrophages treated with lipoolysaccharide through Egr2-Bcl2 signaling. Recent studies suggest a role for TREM-1 in viral immunity. Human immunodeficiency virus-1 (HIV) targets the monocyte/macrophage lineage at varying stages of infection. Emerging data suggest that macrophages are key reservoirs for latent HIV even in individuals on antiretroviral therapy...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28024482/-effects-of-homoharringtonine-combined-with-imatinib-on-k562-cell-apoptosis-and-bcl6-expression
#20
Qian Wang, Wei Ding, Jing-Jing Wu, Yi-Han Ding, Yu-Feng Li
OBJECTIVE: To explore the effects of homoharringtonine (HHT) alone or combined with imatinib (IM) on K562 cell proliferation and apoptosis, as well as the mRNA and protein expression of BCL6. METHODS: The CCK-8 was used to detect the inhibitory effect of drugs on cell growth, the flow cytometry was used to detect the cell apoptosis. The expression of BCL6 protein was assayed by Western blot, and BCL6 mRNA expression was detected by RT-PCR. RESULTS: HHT alone displayed a proliferation inhibition effect with dose- dependent manner, and induced apotosis; after combination of HHT and IM drugs, both the inhibitory rate and the apoptosis rate were significantly increased compared with the drug alone(P<0...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
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