keyword
https://read.qxmd.com/read/38488688/cyclic-nucleotide-induced-bidirectional-long-term-synaptic-plasticity-in-drosophila-mushroom-body
#21
JOURNAL ARTICLE
Daichi Yamada, Andrew M Davidson, Toshihide Hige
Activation of the cAMP pathway is one of the common mechanisms underlying long-term potentiation (LTP). In the Drosophila mushroom body, simultaneous activation of odour-coding Kenyon cells (KCs) and reinforcement-coding dopaminergic neurons activates adenylyl cyclase in KC presynaptic terminals, which is believed to trigger synaptic plasticity underlying olfactory associative learning. However, learning induces long-term depression (LTD) at these synapses, contradicting the universal role of cAMP as a facilitator of transmission...
March 15, 2024: Journal of Physiology
https://read.qxmd.com/read/38488687/illuminating-the-terminal-nerve-uncovering-the-link-between-gnrh-1-neuron-and-olfactory-development
#22
JOURNAL ARTICLE
Enrico Amato, Ed Zandro M Taroc, Paolo E Forni
During embryonic development, the olfactory placode (OP) generates migratory neurons, including olfactory pioneer neurons, cells of the terminal nerve (TN), gonadotropin-releasing hormone-1 (GnRH-1) neurons, and other uncharacterized neurons. Pioneer neurons from the OP induce olfactory bulb (OB) morphogenesis. In mice, GnRH-1 neurons appear in the olfactory system around mid-gestation and migrate via the TN axons to different brain regions. The GnRH-1 neurons are crucial in controlling the hypothalamic-pituitary-gonadal axis...
March 2024: Journal of Comparative Neurology
https://read.qxmd.com/read/38487884/ythdf1-mediated-sphingosine-kinase-2-upregulation-alleviates-bupivacaine-induced-neurotoxicity-via-the-pi3k-akt-axis
#23
JOURNAL ARTICLE
Ru Yuan, Chunxia Wu
BACKGROUND: Bupivacaine (BUP), a long-acting local anesthetic, has been widely used in analgesia and anesthesia. However, evidence strongly suggests that excessive application of BUP may lead to neurotoxicity in neurons. Sphingosine kinase 2 (SPHK2) has been reported to exert neuroprotective effects. In this study, we intended to investigate the potential role and mechanism of SPHK2 in BUP-induced neurotoxicity in dorsal root ganglion (DRG) neurons. METHODS: DRG neurons were cultured with BUP to simulate BUP-induced neurotoxicity  in vitro ...
2024: Human & Experimental Toxicology
https://read.qxmd.com/read/38487552/cross-frequency-cortex-muscle-interactions-are-abnormal-in-young-people-with-dystonia
#24
JOURNAL ARTICLE
Zhenghao Guo, Jean-Pierre Lin, Osvaldo Simeone, Kerry R Mills, Zoran Cvetkovic, Verity M McClelland
Sensory processing and sensorimotor integration are abnormal in dystonia, including impaired modulation of beta-corticomuscular coherence. However, cortex-muscle interactions in either direction are rarely described, with reports limited predominantly to investigation of linear coupling, using corticomuscular coherence or Granger causality. Information-theoretic tools such as transfer entropy detect both linear and non-linear interactions between processes. This observational case-control study applies transfer entropy to determine intra- and cross-frequency cortex-muscle coupling in young people with dystonia/dystonic cerebral palsy...
2024: Brain communications
https://read.qxmd.com/read/38487018/distinct-gabaergic-modulation-of-timing-dependent-ltp-in-ca1-pyramidal-neurons-along-the-longitudinal-axis-of-the-mouse-hippocampus
#25
JOURNAL ARTICLE
Babak Khodaie, Elke Edelmann, Volkmar Leßmann
Synaptic plasticity in the hippocampus underlies episodic memory formation, with dorsal hippocampus being instrumental for spatial memory whereas ventral hippocampus is crucial for emotional learning. Here, we studied how GABAergic inhibition regulates physiologically relevant low repeat spike timing-dependent LTP (t-LTP) at Schaffer collateral-CA1 synapses along the dorsoventral hippocampal axis. We used two t-LTP protocols relying on only 6 repeats of paired spike-firing in pre- and postsynaptic cells within 10 s that differ in postsynaptic firing patterns...
March 15, 2024: IScience
https://read.qxmd.com/read/38486405/gw9508-ameliorates-cognitive-dysfunction-via-autophagy-pathway-in-streptozotocin-induced-mouse-model-of-alzheimer-s-disease
#26
JOURNAL ARTICLE
Yanan Wang, Jingjing Chen, Chen Wang, Tong Chen, Ling He
BACKGROUND: G protein-coupled receptor 40 (GPR40) is a potential drug target for Alzheimer's disease (AD), and its agonist GW9508 ameliorates cognitive impairment by intravenous administration. OBJECTIVES: The present study was conducted to investigate the efficacy of GW9508 administered peripherally on cognitive dysfunction in streptozotocin (STZ)-induced AD mice. METHODS: Seventy male ICR mice were randomly divided into seven groups: vehicle sham group, model, Donepezil, GW9508-L, GW9508-M, GW9508-H, and GW1100 + GW9508-H groups, and administered either vehicle (artificial cerebrospinal fluid [aCSF]) or STZ (3 mg/kg in the vehicle) once a day (9:00 a...
March 14, 2024: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/38486048/early-life-prefrontal-cortex-inhibition-and-early-life-stress-lead-to-long-lasting-behavioral-transcriptional-and-physiological-impairments
#27
JOURNAL ARTICLE
Edênia C Menezes, Heather Geiger, Fabiula F Abreu, Lital Rachmany, Donald A Wilson, Melissa J Alldred, Francisco X Castellanos, Rui Fu, Derya Sargin, André Corvelo, Cátia M Teixeira
Early-life stress has been linked to multiple neurodevelopmental and neuropsychiatric deficits. Our previous studies have linked maternal presence/absence from the nest in developing rat pups to changes in prefrontal cortex (PFC) activity. Furthermore, we have shown that these changes are modulated by serotonergic signaling. Here we test whether changes in PFC activity during early life affect the developing cortex leading to behavioral alterations in the adult. We show that inhibiting the PFC of mouse pups leads to cognitive deficits in the adult comparable to those seen following maternal separation...
March 14, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38485864/gpr39-agonist-tc-g-1008-promoted-mitochondrial-biogenesis-and-improved-antioxidative-capability-via-creb-pgc-1%C3%AE-pathway-following-intracerebral-hemorrhage-in-mice
#28
JOURNAL ARTICLE
Zhongyi Zhang, Ye Yuan, Xingyu Zhang, Lingui Gu, Yuguang Tang, Yutong Zhao, Jinyu Dai, Yihao Tao, Zongyi Xie
Mitochondrial dysfunction and excessive reactive oxygen species production due to impaired mitochondrial biogenesis have been proven to exacerbate secondary brain injury after intracerebral hemorrhage (ICH). The G-protein-coupled receptor 39 (GPR39) agonist TC-G 1008 has been shown to exert anti-oxidative stress effect in acute hypoxic brain injury. Herein, our study aimed to investigate the potential effects of TC-G 1008 on neuronal mitochondrial biogenesis and antioxidative stress in a mouse model of ICH and explore the underlying mechanisms...
March 15, 2024: Translational Stroke Research
https://read.qxmd.com/read/38485616/corrigendum-to-rnai-mediated-knockdown-of-dj-1-leads-to-mitochondrial-dysfunction-via-akt-gsk-3%C3%A3-and-jnk-signaling-pathways-in-dopaminergic-neuron-like-cells-brain-res-bull-146-2019-228-236
#29
Xiao-Ling Zhang, Zhen-Zhen Wang, Qian-Hang Shao, Zhao Zhang, Lin Li, Zhen-Yu Guo, Hong-Mei Sun, Yi Zhang, Nai-Hong Chen
No abstract text is available yet for this article.
March 14, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38485588/advanced-model-based-approach-to-evaluate-human-plasma-cerebrospinal-fluid-and-neuronal-mtorc1-activation-biomarkers-after-nv-5138-administration-in-healthy-volunteers
#30
JOURNAL ARTICLE
Azmi Nasser, J Randall Owen, Roberto Gomeni, Alisa R Kosheleff, Jeanelle Portelli, Lilian W Adeojo, Thomas E Hughes
PURPOSE: NV-5138 ([S]-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid) is an orally bioavailable, small-molecule activator of the mechanistic target of rapamycin complex 1 (mTORC1) pathway in development for treatment-resistant depression. The authors established a model to describe the relationship between plasma and cerebrospinal fluid (CSF) concentrations of NV-5138 and between CSF concentrations and potential biomarkers thought to be associated with mTORC1 activity (ie, orotic acid, N-acetylmethionine, and N-formylmethionine)...
March 13, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38485508/changes-in-structural-plasticity-of-hippocampal-neurons-in-an-animal-model-of-multiple-sclerosis
#31
JOURNAL ARTICLE
Poornima D E Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Sung-Ho Kim, Hongbing Wang, Taekyun Shin, Changjong Moon
Structural plasticity is critical for the functional diversity of neurons in the brain. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for multiple sclerosis (MS), successfully mimicking its key pathological features (inflammation, demyelination, axonal loss, and gliosis) and clinical symptoms (motor and non-motor dysfunctions). Recent studies have demonstrated the importance of synaptic plasticity in EAE pathogenesis. In the present study, we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase (11 days post-immunization, DPI) and chronic phase (28 DPI)...
March 18, 2024: Zoological Research
https://read.qxmd.com/read/38485344/presynaptic-inhibition-of-excitatory-synaptic-transmission-from-the-calcitonin-gene-related-peptide-containing-parabrachial-neurons-to-the-central-amygdala-in-mice-unexpected-influence-of-systemic-inflammation-thereon
#32
JOURNAL ARTICLE
Naoko Sato, Yukari Takahashi, Yae K Sugimura, Fusao Kato
The monosynaptic connection from the lateral parabrachial nucleus (LPB) to the central amygdala (CeA) serves as a fundamental pathway for transmitting nociceptive signals to the brain. The LPB receives nociceptive information from the dorsal horn and spinal trigeminal nucleus and sends it to the "nociceptive" CeA, which modulates pain-associated emotions and nociceptive sensitivity. To elucidate the role of densely expressed mu-opioid receptors (MORs) within this pathway, we investigated the effects of exogenously applied opioids on LPB-CeA synaptic transmission, employing optogenetics in mice expressing channelrhodopsin-2 in LPB neurons with calcitonin gene-related peptide (CGRP)...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38485341/activation-of-%C3%AF-1-receptor-mitigates-estrogen-withdrawal-induced-anxiety-depressive-like-behavior-in-mice-via-restoration-of-gaba-glutamate-signaling-and-neuroplasticity-in-the-hippocampus
#33
JOURNAL ARTICLE
Peng Ren, Jing-Ya Wang, Hong-Lei Chen, Yue Wang, Lin-Yu Cui, Jing-Yao Duan, Wen-Zhi Guo, Yong-Qi Zhao, Yun-Feng Li
Postpartum depression (PPD) is a significant contributor to maternal morbidity and mortality. The Sigma-1 (σ-1) receptor has received increasing attention in recent years because of its ability to link different signaling systems and exert its function in the brain through chaperone actions, especially in neuropsychiatric disorders. YL-0919, a novel σ-1 receptor agonist developed by our institute, has shown antidepressive and anxiolytic effects in a variety of animal models, but effects on PPD have not been revealed...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38485252/mechanical-and-chemical-itch-regulated-by-neuropeptide-y-y1-signaling
#34
JOURNAL ARTICLE
Sihan Chen, Junhui Chen, Dan Tang, Wen Yin, Saihong Xu, Po Gao, Yingfu Jiao, Weifeng Yu
Itch is a somatosensory sensation to remove potential harmful stimulation with a scratching desire, which could be divided into mechanical and chemical itch according to diverse stimuli, such as wool fiber and insect biting. It has been reported that neuropeptide Y (NPY) neurons, a population of spinal inhibitory interneurons, could gate the transmission of mechanical itch, with no effect on chemical itch. In our study, we verified that chemogenetic activation of NPY neurons could inhibit the mechanical itch as well as the chemical itch, which also attenuated the alloknesis phenomenon in the chronic dry skin model...
March 14, 2024: Molecular Pain
https://read.qxmd.com/read/38484863/mark1-regulates-dendritic-spine-morphogenesis-and-cognitive-functions-in-vivo
#35
JOURNAL ARTICLE
Emily C Kelly-Castro, Rebecca Shear, Ankitha H Dindigal, Maitreyee Bhagwat, Huaye Zhang
Dendritic spines play a pivotal role in synaptic communication and are crucial for learning and memory processes. Abnormalities in spine morphology and plasticity are observed in neurodevelopmental and neuropsychiatric disorders, yet the underlying signaling mechanisms remain poorly understood. The microtubule affinity regulating kinase 1 (MARK1) has been implicated in neurodevelopmental disorders, and the MARK1 gene shows accelerated evolution in the human lineage suggesting a role in cognition. However, the in vivo role of MARK1 in synaptogenesis and cognitive functions remains unknown...
March 12, 2024: Experimental Neurology
https://read.qxmd.com/read/38484667/maresin1-improves-hippocampal-neuroinflammation-and-cognitive-function-in-septic-rats-by-activating-the-slc7a11-gpx4-ferroptosis-signaling-pathway
#36
JOURNAL ARTICLE
Huiping Wu, Na Li, Shuang Peng, Haiyan Fu, Zhansheng Hu, Longxiang Su
Sepsis-associated encephalopathy (SAE) is a prevalent complication of sepsis, with hippocampal neuroinflammation playing a crucial role in SAE-induced cognitive impairment. Maresin1 (MaR1), a bioactive docosahexaenoic acid (DHA) metabolite, demonstrates comprehensive anti-inflammatory and neuroprotective attributes. Yet, its protective efficacy against SAE-induced cognitive decline remains unexplored. In this investigation, we implemented a rat SAE model via cecal ligation and puncture (CLP), while lipopolysaccharide (LPS) stimulation of HT22 cells simulated an in vitro SAE model; both models were pre-treated with MaR1...
March 13, 2024: International Immunopharmacology
https://read.qxmd.com/read/38484033/circadian-clock-and-hypoxia
#37
REVIEW
Francesca Sartor, Borja Ferrero-Bordera, Jeffrey Haspel, Markus Sperandio, Paul M Holloway, Martha Merrow
The timing of life on Earth is remarkable: between individuals of the same species, a highly similar temporal pattern is observed, with shared periods of activity and inactivity each day. At the individual level, this means that over the course of a single day, a person alternates between two states. They are either upright, active, and communicative or they lie down in a state of (un)consciousness called sleep where even the characteristic of neuronal signals in the brain shows distinctive properties. The circadian clock governs both of these time stamps-activity and (apparent) inactivity-making them come and go consistently at the same approximate time each day...
March 15, 2024: Circulation Research
https://read.qxmd.com/read/38483995/neuronal-il-17-controls-caenorhabditis-elegans-developmental-diapause-through-cep-1-p53
#38
JOURNAL ARTICLE
Abhishiktha Godthi, Sehee Min, Srijit Das, Johnny Cruz-Corchado, Andrew Deonarine, Kara Misel-Wuchter, Priya D Issuree, Veena Prahlad
During metazoan development, how cell division and metabolic programs are coordinated with nutrient availability remains unclear. Here, we show that nutrient availability signaled by the neuronal cytokine, ILC-17.1, switches Caenorhabditis elegans development between reproductive growth and dormancy by controlling the activity of the tumor suppressor p53 ortholog, CEP-1. Specifically, upon food availability, ILC-17.1 signaling by amphid neurons promotes glucose utilization and suppresses CEP-1/p53 to allow growth...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38483903/blmp-1-is-a-critical-temporal-regulator-of-dietary-restriction-induced-response-in-caenorhabditis-elegans
#39
JOURNAL ARTICLE
Qingyuan Hu, Yunpeng Xu, Mengjiao Song, Yumin Dai, Adam Antebi, Yidong Shen
The extrinsic diet and the intrinsic developmental programs are intertwined. Although extensive research has been conducted on how nutrition regulates development, whether and how developmental programs control the timing of nutritional responses remain barely known. Here, we report that a developmental timing regulator, BLMP-1/BLIMP1, governs the temporal response to dietary restriction (DR). At the end of larval development, BLMP-1 is induced and interacts with DR-activated PHA-4/FOXA, a key transcription factor responding to the reduced nutrition...
March 12, 2024: Cell Reports
https://read.qxmd.com/read/38483902/impaired-oxysterol-liver-x-receptor-signaling-underlies-aberrant-cortical-neurogenesis-in-a-stem-cell-model-of-neurodevelopmental-disorder
#40
JOURNAL ARTICLE
Daniel Cabezas De La Fuente, Claudia Tamburini, Emily Stonelake, Robert Andrews, Jeremy Hall, Michael J Owen, David E J Linden, Andrew Pocklington, Meng Li
The mechanisms by which genomic risks contribute to the onset of neuropsychiatric conditions remain a key challenge and a prerequisite for successful development of effective therapies. 15q11.2 copy number variation (CNV) containing the CYFIP1 gene is associated with autism and schizophrenia. Using stem cell models, we show that 15q11.2 deletion (15q11.2del) and CYFIP1 loss of function (CYFIP1-LoF) lead to premature neuronal differentiation, while CYFIP1 gain of function (CYFIP1-GoF) favors neural progenitor maintenance...
March 13, 2024: Cell Reports
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