keyword
MENU ▼
Read by QxMD icon Read
search

Neurotropic

keyword
https://www.readbyqxmd.com/read/28919920/virulence-determinants-of-west-nile-virus-how-can-these-be-used-for-vaccine-design
#1
REVIEW
Jaclyn A Kaiser, Tian Wang, Alan Dt Barrett
West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3' UTR...
May 2017: Future Virology
https://www.readbyqxmd.com/read/28900831/-18-f-dpa-714-pet-imaging-reveals-global-neuroinflammation-in-zika-virus-infected-mice
#2
Kyle Kuszpit, Bradley S Hollidge, Xiankun Zeng, Robert G Stafford, Sharon Daye, Xiang Zhang, Falguni Basuli, Joseph W Golden, Rolf E Swenson, Darci R Smith, Thomas M Bocan
PURPOSE: The association of Zika virus (ZIKV) infection and development of neurological sequelae require a better understanding of the pathogenic mechanisms causing severe disease. The purpose of this study was to evaluate the ability and sensitivity of positron emission tomography (PET) imaging using [(18)F]DPA-714, a translocator protein (TSPO) 18 kDa radioligand, to detect and quantify neuroinflammation in ZIKV-infected mice. PROCEDURES: We assessed ZIKV-induced pathogenesis in wild-type C57BL/6 mice administered an antibody to inhibit type I interferon (IFN) signaling...
September 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28900083/-the-effects-of-chronic-alcoholization-on-the-expression-of-brain-derived-neurotrophic-factor-and-its-receptors-in-the-brains-of-mice-genetically-predisposed-to-depressive-like-behavior
#3
D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenko
Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in the brain, while the mature form of BDNF is involved in neurogenesis. It is known that chronic alcoholization leads to the activation of apoptotic processes, neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have studied the influence of long-term ethanol exposure on the proBDNF and BDNF protein levels, as well as on the expression of genes that encode these proteins in the brain structures of ASC mice with genetic predisposition to depressive-like behavior and in mice from parental nondepressive CBA strain...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28892964/dengue-haemorrhagic-encephalitis-rare-case-report-with-review-of-literature
#4
Aditya Singh Kutiyal, Chetanya Malik, Gitika Hyanki
Dengue is an endemic arboviral infection prevalent especially in tropical countries including Southern and Southeast Asia. Central Nervous System (CNS) involvement in dengue infection is uncommon. Haemorrhagic encephalitis is a rare presentation in dengue. This is a case of a 58-year-old male who presented with fever, petechial rash and altered sensorium. Dengue serology IgM was reactive and MRI brain was suggestive of haemorrhagic encephalitis. Patient was managed in Intensive Care Unit (ICU) but eventually succumbed to his illness...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891004/cerebral-imaging-and-neurodevelopmental-outcome-after-entero-and-human-parechovirus-sepsis-in-young-infants
#5
Eveline P de Jong, Herma C Holscher, Sylke J Steggerda, Jeanine M M Van Klink, Erika P M van Elzakker, Enrico Lopriore, Frans J Walther, Frank Brus
Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness...
September 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28878777/zika-virus-promotes-neuronal-cell-death-in-a-non-cell-autonomous-manner-by-triggering-the-release-of-neurotoxic-factors
#6
Isabella G Olmo, Toniana G Carvalho, Vivian V Costa, Juliana Alves-Silva, Carolina Z Ferrari, Tatiane C Izidoro-Toledo, Juliana F da Silva, Antonio L Teixeira, Danielle G Souza, Joao T Marques, Mauro M Teixeira, Luciene B Vieira, Fabiola M Ribeiro
Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants born from infected mothers. ZIKV exhibits high neurotropism and promotes neuroinflammation and neuronal cell death. We have recently demonstrated that N-methyl-d-aspartate receptor (NMDAR) blockade by memantine prevents ZIKV-induced neuronal cell death. Here, we show that ZIKV induces apoptosis in a non-cell autonomous manner, triggering cell death of uninfected neurons by releasing cytotoxic factors...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28878079/minocycline-has-anti-inflammatory-effects-and-reduces-cytotoxicity-in-an-ex-vivo-spinal-cord-slice-culture-model-of-west-nile-virus-infection
#7
Eamon D Quick, Scott Seitz, Penny Clarke, Kenneth L Tyler
West Nile virus (WNV) is a neurotropic flavivirus that can cause significant neurological disease. Mouse models of WNV infection demonstrate that a pro-inflammatory environment is induced within the central nervous system (CNS) after WNV infection leading to entry of activated peripheral immune cells. We utilized ex vivo spinal cord slice cultures (SCSC) to demonstrate that anti-inflammatory mechanisms may also play a role in WNV-induced pathology and/or recovery. Microglia are a type of macrophage that function as resident CNS immune cells...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28874814/t-bet-but-not-gata3-overexpression-is-detrimental-in-a-neurotropic-viral-infection
#8
Fumitaka Sato, Eiichiro Kawai, Nicholas E Martinez, Seiichi Omura, Ah-Mee Park, Satoru Takahashi, Keigyou Yoh, Ikuo Tsunoda
Intracerebral Theiler's murine encephalomyelitis virus (TMEV) infection in mice induces inflammatory demyelination in the central nervous system. Although C57BL/6 mice normally resistant to TMEV infection with viral clearance, we have previously demonstrated that RORγt-transgenic (tg) C57BL/6 mice, which have Th17-biased responses due to RORγt overexpression in T cells, became susceptible to TMEV infection with viral persistence. Here, using T-bet-tg C57BL/6 mice and Gata3-tg C57BL/6 mice, we demonstrated that overexpression of T-bet, but not Gata3, in T cells was detrimental in TMEV infection...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874392/zika-virus-has-oncolytic-activity-against-glioblastoma-stem-cells
#9
Zhe Zhu, Matthew J Gorman, Lisa D McKenzie, Jiani N Chai, Christopher G Hubert, Briana C Prager, Estefania Fernandez, Justin M Richner, Rong Zhang, Chao Shan, Eric Tycksen, Xiuxing Wang, Pei-Yong Shi, Michael S Diamond, Jeremy N Rich, Milan G Chheda
Glioblastoma is a highly lethal brain cancer that frequently recurs in proximity to the original resection cavity. We explored the use of oncolytic virus therapy against glioblastoma with Zika virus (ZIKV), a flavivirus that induces cell death and differentiation of neural precursor cells in the developing fetus. ZIKV preferentially infected and killed glioblastoma stem cells (GSCs) relative to differentiated tumor progeny or normal neuronal cells. The effects against GSCs were not a general property of neurotropic flaviviruses, as West Nile virus indiscriminately killed both tumor and normal neural cells...
September 5, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28867493/taking-the-defensive-immune-control-of-zika-virus-infection
#10
REVIEW
James R Bowen, Matthew G Zimmerman, Mehul S Suthar
ZIKV is a neurotropic mosquito-borne flavivirus that has recently emerged in the Americas and is a pathogen of significant public health concern across the world. ZIKV was first isolated in Uganda in 1947 and remained dormant in Africa and Asia for decades, with sporadic outbreaks characterized by a mild self-limiting disease in humans. The emergence of ZIKV in the Americas corresponded with enhanced disease severity and congenital Zika syndrome, a phenotype characterized by severe microcephaly, brain anomalies, ocular anomalies, congenital contractures and neurological impairments...
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28867340/bdnf-val-66-met-polymorphism-tunes-frontolimbic-circuitry-during-affective-contextual-learning
#11
Mbemba Jabbi, Brett Cropp, Tiffany Nash, Philip Kohn, J Shane Kippenhan, Joseph C Masdeu, Raghav Mattay, Bhaskar Kolachana, Karen F Berman
Adaptive learning impairments are common in cognitive and behavioral disorders, but the neurogenetic mechanisms supporting human affective learning are poorly understood. We designed a higher-order contextual learning task in which healthy participants genotyped for the Val(66)Met polymorphism of the brain derived neurotropic factor gene (BDNF) were required to choose the member of a picture pair most congruent with the emotion in a previously-viewed facial expression video in order to produce an advantageous monetary outcome...
August 31, 2017: NeuroImage
https://www.readbyqxmd.com/read/28854791/pcr-based-approach-for-qualitative-molecular-analysis-of-six-neurotropic-pathogens
#12
R Ferese, L Scorzolini, R Campopiano, V Albano, A M Griguoli, E Giardina, S Scala, L Ryskalin, C D'Alessio, S Zampatti, R Fantozzi, M Storto, F Fornai, S Gambardella
In the last few years, polymerase chain reaction analysis is frequently required to improve the detection of pathogen infections in central nervous system as a potential cause of neurological disorders and neuropsychiatric symptoms. The goal of this paper is to set up a fast, cheap and reliable molecular approach for qualitative detection of six neurotropic pathogens. A method based on PCR has been designed and implemented to guarantee the qualitative DNA detection of herpes simplex virus types 1 and 2 (HSVI/II), Epstein-Barr virus (EBV), cytomegalovirus (CMV), varicella-zoster virus (VZV), rubella virus (RUBV) and Toxoplasma gondii in the cerebrospinal fluid, where otherwise they are barely detectable...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28846695/novel-and-ultra-rare-damaging-variants-in-neuropeptide-signaling-are-associated-with-disordered-eating-behaviors
#13
Michael Lutter, Ethan Bahl, Claire Hannah, Dabney Hofammann, Summer Acevedo, Huxing Cui, Carrie J McAdams, Jacob J Michaelson
OBJECTIVE: Eating disorders develop through a combination of genetic vulnerability and environmental stress, however the genetic basis of this risk is unknown. METHODS: To understand the genetic basis of this risk, we performed whole exome sequencing on 93 unrelated individuals with eating disorders (38 restricted-eating and 55 binge-eating) to identify novel damaging variants. Candidate genes with an excessive burden of predicted damaging variants were then prioritized based upon an unbiased, data-driven bioinformatic analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28835503/murine-olfactory-bulb-interneurons-survive-infection-with-a-neurotropic-coronavirus
#14
D Lori Wheeler, Jeremiah Athmer, David K Meyerholz, Stanley Perlman
Viral infection of the central nervous system is complicated by the mostly irreplaceable nature of neurons, as the loss of neurons has the potential to result in permanent damage to brain function. However, whether neurons or other cells in the CNS sometimes survive infection and the effects of infection on neuronal function are largely unknown. To address this question, we used the rJHM strain (rJ) of mouse hepatitis virus, (MHV), a neurotropic coronavirus, which causes acute encephalitis in susceptible strains of mice...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28835497/cysteines-and-n-glycosylation-sites-conserved-among-all-alphaherpesviruses-regulate-membrane-fusion-in-herpes-simplex-virus-type-1-infection
#15
Paul J F Rider, Misagh Naderi, Scott Bergeron, Vladimir N Chouljenko, Michal Brylinski, Konstantin G Kousoulas
Neurotropism is a defining characteristic of alphaherpesvirus pathogenicity. Glycoprotein K (gK) is a conserved virion glycoprotein of all alphaherpesviruses that is not found in other herpesvirus subfamilies. The extracellular amino terminus of gK has been shown to be important in the ability of the prototypic alphaherpesvirus HSV-1 to enter neurons via axonal termini. Herein, we determined the role of the two conserved N-linked glycosylation (N48 and N58) sites of gK in virus-induced cell fusion and replication...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28831740/expression-of-mir-155-associated-with-toll-like-receptors-3-7-and-9-transcription-in-the-olfactory-bulbs-of-cattle-naturally-infected-with-bhv5
#16
Bruna R S M Oliveira, Flavia V Vieira, Dielson de S Vieira, Sergio E L da Silva, Roberto Gameiro, Eduardo F Flores, Tereza C Cardoso
Bovine herpesvirus 5 (BHV5) infection of young cattle is frequently associated with fatal neurological disease and, as such, represents an attractive model for studying the pathogenesis of viral-induced meningoencephalitis. Following replication in the nasal mucosa, BHV5 invades the central nervous system (CNS) mainly through the olfactory pathway. The innate immune response triggered by the host face to virus replication through the olfactory route is poorly understood. Recently, an upregulation of conserved pathogen-associated molecular pattern, as Toll-like receptors (TLRs), has been demonstrated in the CNS of BHV5 experimentally infected cows...
August 22, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28829736/case-report-zika-virus-meningoencephalitis-and-myelitis-and-associated-magnetic-resonance-imaging-findings
#17
Faruq Pradhan, Joseph D Burns, Ahmed Agameya, Avignat Patel, Mohammad Alfaqih, Juan E Small, Winnie Ooi
Zika virus (ZIKV) has a wide clinical spectrum of associated neurologic disease including microcephaly and Guillain-Barre syndrome but, despite its known neurotropism, ZIKV meningoencephalitis and myelitis have been rare complications. We describe a case of ZIKV meningoencephalitis and probable myelitis and its associated magnetic resonance imaging findings that rapidly resolved during recovery in a previously healthy adult.
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28827150/the-role-of-the-leukemia-inhibitory-factor-receptor-in-neuroprotective-signaling
#18
REVIEW
Stephanie M Davis, Keith R Pennypacker
Several neurotropic cytokines relay their signaling through the leukemia inhibitory factor receptor. This 190kDa subunit couples with the 130kDa gp130 subunit to transduce intracellular signaling in neurons and oligodendrocytes that leads to expression of genes associated with neurosurvival. Moreover, activation of this receptor alters the phenotype of immune cells to an anti-inflammatory one. Although cytokines that activate the leukemia inhibitory factor receptor have been studied in the context of neurodegenerative disease, therapeutic targeting of the specific receptor subunit has been understudied in by comparison...
August 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28822268/neural-precursor-cells-derived-from-induced-pluripotent-stem-cells-exhibit-reduced-susceptibility-to-infection-with-a-neurotropic-coronavirus
#19
Vrushali Mangale, Brett S Marro, Warren C Plaisted, Craig M Walsh, Thomas E Lane
The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-γ treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects...
August 16, 2017: Virology
https://www.readbyqxmd.com/read/28820378/indication-of-cross-species-transmission-of-astrovirus-associated-with-encephalitis-in-sheep-and-cattle
#20
Céline L Boujon, Michel C Koch, Daniel Wüthrich, Simea Werder, Dennis Jakupovic, Rémy Bruggmann, Torsten Seuberlich
We report the identification of a neurotropic astrovirus associated with encephalitis in a sheep. This virus is genetically almost identical to an astrovirus recently described in neurologically diseased cattle. The similarity indicates that astroviruses of the same genotype may cause encephalitis in different species.
September 2017: Emerging Infectious Diseases
keyword
keyword
32140
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"