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https://www.readbyqxmd.com/read/29329287/isolation-and-complete-genome-analysis-of-neurotropic-dengue-virus-serotype-3-from-the-cerebrospinal-fluid-of-an-encephalitis-patient
#1
Rama Dhenni, Mulya Rahma Karyanti, Nina Dwi Putri, Benediktus Yohan, Frilasita A Yudhaputri, Chairin Nisa Ma'roef, Araniy Fadhilah, Aditya Perkasa, Restuadi Restuadi, Hidayat Trimarsanto, Irawan Mangunatmadja, Jeremy P Ledermann, Ronald Rosenberg, Ann M Powers, Khin Saw Aye Myint, R Tedjo Sasmono
Although neurological manifestations associated with dengue viruses (DENV) infection have been reported, there is very limited information on the genetic characteristics of neurotropic DENV. Here we describe the isolation and complete genome analysis of DENV serotype 3 (DENV-3) from cerebrospinal fluid of an encephalitis paediatric patient in Jakarta, Indonesia. Next-generation sequencing was employed to deduce the complete genome of the neurotropic DENV-3 isolate. Based on complete genome analysis, two unique and nine uncommon amino acid changes in the protein coding region were observed in the virus...
January 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29326229/genomic-understanding-of-an-infectious-brain-disease-from-the-desert
#2
Leandro F Moreno, Abdalla A O Ahmed, Balázs Brankovics, Christina A Cuomo, Steph B J Menken, Saad J Taj-Aldeen, Hani Faidah, J Benjamin Stielow, Marcus de M Teixeira, Francesc X Prenafeta-Boldú, Vania A Vicente, Sybren de Hoog
Rhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individuals. If untreated, the infection is fatal. Outside of humans, the environmental niche of R. mackenziei is unknown, and the fungus has been only cultured from brain biopsies. In this paper we describe the whole genome re-sequencing of two Rhinocladiella mackenziei strains from patients in Saudi Arabia and Qatar...
January 11, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29324904/prohibitin-plays-a-critical-role-in-enterovirus-71-neuropathogenesis
#3
Issac Horng Khit Too, Isabelle Bonne, Eng Lee Tan, Justin Jang Hann Chu, Sylvie Alonso
A close relative of poliovirus, enterovirus 71 (EV71) is regarded as an important neurotropic virus of serious public health concern. EV71 causes Hand, Foot and Mouth Disease and has been associated with neurological complications in young children. Our limited understanding of the mechanisms involved in its neuropathogenesis has hampered the development of effective therapeutic options. Here, using a two-dimensional proteomics approach combined with mass spectrometry, we have identified a unique panel of host proteins that were differentially and dynamically modulated during EV71 infection of motor-neuron NSC-34 cells, which are found at the neuromuscular junctions where EV71 is believed to enter the central nervous system...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29310062/are-infectious-agents-involved-in-the-pathogenesis-of-postpartum-psychosis
#4
Lot D de Witte, Gijsje Snijders, Manja Litjens, Astrid M Kamperman, Steven A Kushner, René S Kahn, Veerle Bergink
BACKGROUND: Since postpartum psychosis has been linked to activation of the immune system, it has been hypothesized that infectious agents may be involved in the pathogenesis of this disorder. We therefore investigated whether exposure to pathogens that can infect the central nervous system is increased in patients with postpartum psychosis. METHODS: We measured the prevalence and titers of immunoglobulin G (IgG) and M (IgM) to herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), Epstein-Barr virus (EBV), cytomegalovirus (CMV) and Toxoplasma Gondii (TG) in a cohort of patients with postpartum psychosis (n = 81) and compared these to matched postpartum controls...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29306858/guillain-barr%C3%A3-syndrome-with-exaggerated-pleocytosis-and-anti-gm1-ganglioside-antibodies
#5
Gabriel T Doctor, Sian K Alexander, Aleksandar Radunovic
An 81-year-old man presented with fever, confusion and rapidly-progressive flaccid tetraparesis. Clinical presentation and neurophysiology were consistent with a severe axonal polyneuropathy. Anti-GM1 and Campylobacter serology were both positive, consistent with postinfectious axonal-variant Guillain-Barré syndrome (GBS). GBS is characterised by albuminocytological dissociation, where an elevated protein and acellular cerebrospinal fluid are typical. However, in this case, CSF analysis revealed an exaggerated pleocytosis (72 white blood cells (WBC)/mm3)...
January 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29305370/varicella-zoster-meningitis-an-atypical-case-of-zoster-reactivation-in-immunocompetent-young-adult
#6
Muhammad Farhan Khaliq, Tanureet Kochar, Molly John
Varicella virus is a neurotropic virus that can reactivate later in life to cause zoster or shingles. Typically, it affects elderly, immunocompromised population. We report an unusual case of an immunocompetent young adult presenting with occipital headache and zoster rash, without preherpetic and postherpetic neuralgia, who was diagnosed with varicella meningitis on Polymerase chain reaction (PCR). He was treated with intravenous acyclovir and later discharged on famciclovir. Diagnosis of varicella meningitis is difficult in the absence of typical features of zoster rash and requires high index of suspicion...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29302849/low-vs-high-alcohol-central-benefits-vs-detriments
#7
REVIEW
Yousef Tizabi, Bruk Getachew, Clifford L Ferguson, Antonei B Csoka, Karl M Thompson, Alejandra Gomez-Paz, Jana Ruda-Kucerova, Robert E Taylor
The dose-dependent effects of alcohol, where the initial euphoric and stimulant effects initiated by the exposure to low ethanol levels can quickly lead to a deadly consequence are well established. Thus, high blood alcohol concentration (BAC), as seen in alcoholics, can cause significant damage to various organs. At low concentrations (e.g., 10 mg% or lower), however, beneficial effects of alcohol, particularly on cardiovascular function have been reported. Although, the latter assertion has been challenged by recent epidemiological studies, protective effects of low alcohol concentrations in vitro and in vivo relevant to the central nervous system (CNS) is well documented...
January 4, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29297316/a-database-of-human-genes-and-a-gene-network-involved-in-response-to-tick-borne-encephalitis-virus-infection
#8
Elena V Ignatieva, Alexander V Igoshin, Nikolay S Yudin
BACKGROUND: Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness. Very little is known about genetic factors predisposing to severe forms of disease caused by TBEV. The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins...
December 28, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29288952/effects-of-the-brain-derived-neurotropic-factor-variant-val66met-on-cortical-structure-in-late-childhood-and-early-adolescence
#9
Celia Maria de Araujo, Andre Zugman, Walter Swardfager, Sintia Iole Nogueira Belangero, Vanessa Kiyomi Ota, Leticia Maria Spindola, Hakon Hakonarson, Renata Pellegrino, Ary Gadelha, Giovanni Abrahão Salum, Pedro Mario Pan, Luciana Monteiro de Moura, Marco Del Aquilla, Felipe Almeida Picon, Edson Amaro, João Ricardo Sato, Elisa Brietzke, Rodrigo Grassi-Oliveira, Luis Augusto P Rohde, Euripedes Constantino Miguel, Rodrigo A Bressan, Andrea Parolin Jackowski
BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. METHODOLOGY: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder...
December 20, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29287230/the-oc43-human-coronavirus-envelope-protein-is-critical-for-infectious-virus-production-and-propagation-in-neuronal-cells-and-is-a-determinant-of-neurovirulence-and-cns-pathology
#10
Jenny K Stodola, Guillaume Dubois, Alain Le Coupanec, Marc Desforges, Pierre J Talbot
The OC43 strain of human coronavirus (HCoV-OC43) is an ubiquitous respiratory tract pathogen possessing neurotropic capacities. Coronavirus structural envelope (E) protein possesses specific motifs involved in protein-protein interaction or in homo-oligomeric ion channel formation, which are known to play various roles including in virion morphology/assembly and in cell response to infection and/or virulence. Making use of recombinant viruses either devoid of the E protein or harboring mutations either in putative transmembrane domain or PDZ-binding motif, we demonstrated that a fully functional HCoV-OC43 E protein is first needed for optimal production of recombinant infectious viruses...
December 26, 2017: Virology
https://www.readbyqxmd.com/read/29287075/association-of-serum-brain-derived-neurotropic-factor-with-duration-of-drug-naive-period-and-positive-negative-symptom-scores-in-drug-naive-schizophrenia
#11
Abdurrahim Bakirhan, Safak Yalcin Sahiner, Ismail Volkan Sahiner, Yasir Safak, Erol Goka
INTRODUCTION: The aim of this study was to compare the serum brain derived neurotropic factor (BNDF) levels of patients with schizophrenia who had never received an antipsychotic treatment with those of a control group. Also, to analyze the relationship between the Positive and Negative Symptom Scale (PANSS) scores and BDNF levels of the patients during the period they were drug-naive. MATERIALS AND METHODS: The sample of the study comprised patients who presentedto the Psychiatry Clinic and were admitted after a distinctive schizophrenia diagnosis was made in accordance with the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) diagnosis classification and who were not using and never had any antipsychotic medicine...
2017: PloS One
https://www.readbyqxmd.com/read/29286622/drug-target-discovery-methods-in-targeting-neurotropic-parasitic-amoebae
#12
Abdul Mannan Baig, Nuzair Waliani, Saiqa Karim
Neurotropic parasitic amoebal infections have imposed an enormous challenge to chemotherapy in patients who fall victims to the infections caused by them. Conventional antibiotics that are given to treat these infections have a low patient compliance because of the serious adverse effects that are associated with their use. Additionally, the growing incidence of the development of drug resistance by the neurotropic parasites like Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba spp has made the drug therapy more challenging...
December 29, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29285390/elevated-erythrocyte-sedimentation-rate-is-associated-with-metastatic-disease-and-worse-survival-in-patients-with-cutaneous-malignant-melanoma
#13
Faruk Tas, Kayhan Erturk
Elevated erythrocyte sedimentation rate (ESR) is common in cancer patients and it may affect survival. However, its clinical role and prognostic significance remain unknown in melanoma patients. The objective of the present study was to determine the clinical significance of the ESR levels in cutaneous melanoma patients. A total of 139 cutaneous melanoma patients were enrolled in this study and were retrospectively investigated. The median age of the patients was 52 years (range, 16-88 years). The median ESR was 22 mm/h (range, 2-122 mm/h)...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285381/effect-of-biology-on-the-outcome-of-female-melanoma-patients
#14
Kayhan Erturk, Faruk Tas
The aim of the present study was to investigate plausible explanations for the favorable outcome of female melanoma patients and determine the effect of biology on this outcome. Data from 1,169 cutaneous melanoma patients were retrospectively analyzed. Cox proportional hazards models were used and the confounding factors on the survival difference were analyzed by a forward step multivariate modification method. The majority of the factors contributing to poor prognosis were significantly more pronounced in male melanoma patients...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29283237/memory-cognition-and-the-endogenous-evoked-potentials-of-the-brain-the-estimation-of-the-disturbance-of-cognitive-functions-and-capacity-of-working-memory-without-the-psychological-testing
#15
V V Gnezditskiy, O S Korepina, A V Chatskaya, O I Klochkova
Cognition, cognitive and memory impairments is widely discussed in the literature, especially in the psycho physiological and the neurologic. In essence, this literature is dedicated to the psycho physiological tests, different scales. However, instrument neurophysiologic methods not so widely are used for these purposes. This review is dedicated to the instrument methods of neurophysiology, in particular to the endogenous evoked potentials method Р 300 (by characteristic latency 300 ms), in the estimation of cognitive functions and memory, to their special features dependent on age and to special features to their changes with the pathology...
January 2017: Uspekhi Fiziologicheskikh Nauk
https://www.readbyqxmd.com/read/29281967/the-effects-of-vitamin-d-administration-on-brain-inflammatory-markers-in-high-fat-diet-induced-obese-rats
#16
Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian, Parviz Shahabi
BACKGROUND: Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats. METHODS: In the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage...
December 28, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29277679/intermittent-fasting-promotes-prolonged-associative-interactions-during-synaptic-tagging-capture-by-altering-the-metaplastic-properties-of-the-ca1-hippocampal-neurons
#17
Ananya Dasgupta, Joonki Kim, Anoop Manakkadan, Thiruma V Arumugam, Sreedharan Sajikumar
Metaplasticity is the inherent property of a neuron or neuronal population to undergo activity-dependent changes in neural function that modulate subsequent synaptic plasticity. Here we studied the effect of intermittent fasting (IF) in governing the interactions of associative plasticity mechanisms in the pyramidal neurons of rat hippocampal area CA1. Late long-term potentiation and its associative mechanisms such as synaptic tagging and capture at an interval of 120 min were evaluated in four groups of animals, AL (Ad libitum), IF12 (daily IF for 12 h), IF16 (daily IF for 16 h) and EOD (every other day IF for 24 h)...
December 19, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29277374/aerobic-exercise-as-an-adjuvant-to-aphasia-therapy-theory-preliminary-findings-and-future-directions
#18
Stacy M Harnish, Amy D Rodriguez, Deena Schwen Blackett, Christopher Gregory, Lauren Seeds, Jeffrey H Boatright, Bruce Crosson
PURPOSE: This study investigated whether participation in aerobic exercise enhances the effects of aphasia therapy, and the degree to which basal serum brain-derived neurotropic factor (BDNF) concentrations fluctuate after the beginning of aerobic exercise or stretching activities in individuals with poststroke aphasia. METHODS: The study used a single-subject, multiple-baseline design. Seven individuals with chronic poststroke aphasia participated in 2 Blocks of aphasia therapy: aphasia therapy alone (Block 1), followed by aphasia therapy with the addition of aerobic activity via bicycle ergometer (n = 5) or stretching (n = 2) (Block 2)...
December 22, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29277119/brain-derived-neurotropic-factor-bdnf-heterozygous-mice-are-more-susceptible-to-synaptic-protein-loss-in-cerebral-cortex-during-high-fat-diet
#19
İsmail Abidin, Selcen Aydin-Abidin, Akin Bodur, İmran İnce, Ahmet Alver
In this study we aimed to investigate whether reduced BDNF levels aggravate the susceptibility of the brain to hazardous effects of high fat diet. For this purpose, we fed BDNF heterozygous mice and wild type littermates with normal and high fat diet for 16 weeks. Concentrations of two synaptic proteins (SNAP-25 and PSD-95) and oxidative stress parameters (MDA, SOD, CAT) were evaluated in the cortex after diet period. Interestingly, body weights of BDNF heterozygous groups fed with control diet were higher than their littermates and heterozygous mice fed with HFD were the heaviest in all experimental groups...
December 25, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29261094/postmortem-findings-in-patient-with-guillain-barr%C3%A3-syndrome-and-zika-virus-infection
#20
Emilio Dirlikov, José V Torres, Roosecelis Brasil Martines, Sarah Reagan-Steiner, George Venero Pérez, Aidsa Rivera, Chelsea Major, Desiree Matos, Jorge Muñoz-Jordan, Wun-Ju Shieh, Sherif R Zaki, Tyler M Sharp
Postmortem examination results of a patient with Guillain-Barré syndrome and confirmed Zika virus infection revealed demyelination of the sciatic and cranial IV nerves, providing evidence of the acute demyelinating inflammatory polyneuropathy Guillain-Barré syndrome variant. Lack of evidence of Zika virus in nervous tissue suggests that pathophysiology was antibody mediated without neurotropism.
January 2018: Emerging Infectious Diseases
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