Hyun Ha Park, Byeong-Hyeon Kim, Seol Hwa Leem, Yong Ho Park, Hyunju Chung, Doo-Han Yoo, Insu Park, Yunkwon Nam, Sujin Kim, Soo Jung Shin, Minho Moon
BACKGROUND: Traditional Oriental Medicines (TOMs) formulated using a variety of medicinal plants have a low risk of side effects. In previous studies, five TOMs, namely Dangguijakyaksan, Hwanglyeonhaedoktang, Ukgansan, Palmijihwanghwan, and Jowiseungchungtang have been commonly used to treat patients with Alzheimer's disease. However, only a few studies have investigated the effects of these five TOMs on tau pathology. OBJECTIVE: This study aimed to examine the effect of five TOMs on various tau pathologies, including post-translational modifications, aggregation and deposition, tau-induced neurotoxicity, and tau-induced neuroinflammation...
March 13, 2024: Current Medicinal Chemistry