Baolong Liu, Phuong Linh Nguyen, Han Yu, Xingzhi Li, Huiren Wang, Jeffrey Price, Meng Niu, Chittibabu Guda, Xiao Cheng, Xinghui Sun, Regis Moreau, Amanda Ramer-Tait, Michael J Naldrett, Sophie Alvarez, Jiujiu Yu
BACKGROUND: Macrophages are highly plastic innate immune cells that play key roles in host defense, tissue repair, and homeostasis maintenance. In response to divergent stimuli, macrophages rapidly alter their functions and manifest a wide polarization spectrum with two extremes: M1 or classical activation and M2 or alternative activation. Extracellular vesicles (EVs) secreted from differentially activated macrophages have been shown to have diverse functions, which are primarily attributed to their microRNA cargos...
September 28, 2023: Journal of Nanobiotechnology