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https://www.readbyqxmd.com/read/28550740/multi-resolution-classification-of-exhaled-aerosol-images-to-detect-obstructive-lung-diseases-in-small-airways
#1
Jinxiang Xi, Weizhong Zhao, Jiayao Eddie Yuan, Biwei Cao, Linlin Zhao
Exhaled aerosol patterns have been used to detect obstructive respiratory diseases in the upper airways. Signals from small airway diseases are weak and may not manifest themselves in the exhaled aerosol patterns. Therefore, it will be more challenging to detect abnormalities in small airways. The objective of this study is to develop a simulation-based classification model that can accurately classify small airway diseases. The model performance was evaluated in five obstructed models that are located in lung bifurcations G7-9...
May 20, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28550667/-clinical-features-and-risk-factors-for-recurrence-in-mucinous-breast-cancer
#2
L Lei, Z Z Chen, Y B Zheng, B Chen, X Wang, X J Wang
Objective: To investigate the clinicopathological characteristic and risk factors for recurrence in different subtypes of mucinous breast cancer(MBC). Methods: Clinical data of 97 MBC patients at Zhejiang Cancer Hospital from August 2005 to November 2012 were retrospectively analyzed. All of patients were divided into 3 subtypes according to the mucinous components in the tumors, named as partial mixed MBC with less than 50% of mucinous components, main mixed MBC where the mucinous component accounted for 50% to 90%, and pure MBC with more than 90% of mucinous components...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28550649/improved-formula-see-text-determination-in-23-na-35-cl-and-17-o-mri-using-iterative-partial-volume-correction-based-on-1-h-mri-segmentation
#3
Sebastian C Niesporek, Reiner Umathum, Thomas M Fiedler, Peter Bachert, Mark E Ladd, Armin M Nagel
OBJECTIVE: Functional parameters can be measured with the help of quantitative non-proton MRI where exact relaxometry parameters are needed. Investigation of [Formula: see text] is often biased by strong partial volume (PV) effects. Hence, in this work a PV correction algorithm approach was evaluated that uses iteratively adapted [Formula: see text]-values and high-resolution structural (1)H data to determine transverse relaxation in non-proton MRI more accurately. MATERIALS AND METHODS: Simulations, a phantom study and in vivo (23)Na, (17)O and (35)Cl MRI measurements of five healthy volunteers were performed to evaluate the algorithm...
May 26, 2017: Magma
https://www.readbyqxmd.com/read/28550589/carbon-dioxide-co2-angiography-as-an-option-for-endovascular-abdominal-aortic-aneurysm-repair-evar-in-patients-with-chronic-kidney-disease-ckd
#4
Chiara De Angelis, Francesco Sardanelli, Matteo Perego, Marco Alì, Francesco Casilli, Luigi Inglese, Giovanni Mauri
To assess feasibility, efficacy and safety of carbon dioxide (CO2) digital subtraction angiography (DSA) to guide endovascular aneurysm repair (EVAR) in a cohort of patients with chronic kidney disease (CKD). After Ethical Committee approval, the records of 13 patients (all male, mean age 74.6 ± 8.0 years) with CKD, who underwent EVAR to exclude an abdominal aortic aneurysm (AAA) under CO2 angiography guidance, were reviewed. The AAA to be excluded had a mean diameter of 52.0 ± 8.0 mm. CO2 angiography was performed by automatic (n = 7) or hand (n = 6) injection...
May 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28550588/value-of-ct-signs-and-measurements-as-a-predictor-of-pulmonary-hypertension-and-mortality-in-symptomatic-severe-aortic-valve-stenosis
#5
Matthias Eberhard, Monika Mastalerz, Jovana Pavicevic, Thomas Frauenfelder, Fabian Nietlispach, Francesco Maisano, Felix C Tanner, Thi Dan Linh Nguyen-Kim
To assess the value of computed tomography (CT) for non-invasive detection of pulmonary hypertension (PH) in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) and to correlate CT measurements and signs with mortality after TAVI. 257 TAVI patients (median 84 years; 134 females) with both right heart catheterisation (RHC) and CT within 3 days were retrospectively analyzed. According to guidelines PH was defined as mean pulmonary artery pressure ≥25 mmHg in RHC. CT-signs for PH assessment were evaluated...
May 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28550523/morphological-evaluation-of-retinal-ganglion-cells-expressing-the-l132c-t159c-chr2-mutant-transgene-in-young-adult-cynomolgus-monkeys
#6
Wenyao Wang, Yan Nan, Zhuo-Hua Pan, Mingliang Pu
To characterize recombinant AAV2 (rAAV2)-mediated expression of L132C/T159C ChR2 mutant in retinal ganglion cells (RGCs) of young adult cynomolgus monkeys. rAAV2 vectors carrying a fusion construct of the ChR2 mutant and GFP (ChR2-GFP) were delivered to the vitreous chamber by intravitreal injection. Expression patterns of the ChR2 mutant in RGCs were examined by immunohistochemical methods three months after injection. The RNA-binding protein with multiple splicing (RBPMS) was used as an RGC specific marker to differentiate RGCs from other retinal neurons and non-neuronal cells...
May 25, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28550521/assessment-of-periodontal-bone-level-revisited-a-controlled-study-on-the-diagnostic-accuracy-of-clinical-evaluation-methods-and-intra-oral-radiography
#7
Véronique Christiaens, Hugo De Bruyn, Eric Thevissen, Sebastiaan Koole, Melissa Dierens, Jan Cosyn
OBJECTIVES: The accuracy of analogue and especially digital intra-oral radiography in assessing interdental bone level needs further documentation. The aim of this study was to compare clinical and radiographic bone level assessment to intra-surgical bone level registration (1) and to identify the clinical variables rendering interdental bone level assessment inaccurate (2). MATERIALS AND METHODS: The study sample included 49 interdental sites in 17 periodontitis patients...
May 26, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28550488/the-value-of-preoperative-positron-emission-tomography-computed-tomography-in-node-negative-endometrial-cancer-on-magnetic-resonance-imaging
#8
Jeong-Yeol Park, Jong Jin Lee, Hyuck Jae Choi, In Hye Song, Chang Ohk Sung, Hye Ok Kim, Sun-Young Chae, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: The aim of this study was to investigate the value of [18F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in predicting lymph node status in node-negative endometrial cancer on preoperative magnetic resonance imaging (MRI). METHODS: Patients with endometrial cancer who underwent both preoperative MRI and FDG-PET/CT followed by hysterectomy and lymphadenectomy were initially included. We then enrolled patients with MRI-defined node-negative disease (lymph nodes <1 cm in the short-axis diameter, or no visible lymph node)...
May 26, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28550472/salt-induced-na-k-atpase-%C3%AE-%C3%AE-expression-involves-soluble-adenylyl-cyclase-in-endothelial-cells
#9
Mirja Mewes, Johanna Nedele, Katrin Schelleckes, Olga Bondareva, Malte Lenders, Kristina Kusche-Vihrog, Hans-Joachim Schnittler, Stefan-Martin Brand, Boris Schmitz, Eva Brand
High dietary salt intake may lead to vascular stiffness, which predicts cardiovascular diseases such as heart failure, and myocardial and cerebral infarctions as well as renal impairment. The vascular endothelium is a primary target for deleterious salt effects leading to dysfunction and endothelial stiffness. We hypothesize that the Ca(2+)- and bicarbonate-activated soluble adenylyl cyclase (sAC) contributes to Na(+)/K(+)-ATPase expression regulation in vascular endothelial cells and is an important regulator of endothelial stiffness...
May 26, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28550469/isolation-and-functional-characterization-of-3-phosphoglycerate-dehydrogenase-involved-in-salt-responses-in-sugar-beet
#10
Kunihide Kito, Koichi Tsutsumi, Vandna Rai, Cattarin Theerawitaya, Suriyan Cha-Um, Nana Yamada-Kato, Shota Sakakibara, Yoshito Tanaka, Teruhiro Takabe
The present study investigated the significance of serine biosynthetic genes for salt stress in sugar beet (Beta vulgaris). We isolated a total of four genes, two each encoding D-3-phosphoglycerate dehydrogenase (BvPGDHa and BvPGDHb) and serine hydroxymethyl transferase (BvSHMTa and BvSHMTb). mRNA transcriptional expression for BvPGDHa was significantly enhanced under salt stress conditions in both leaves and roots of sugar beet, whereas it was reduced for BvPGDHb. On the other hand, BvSHMTa was expressed transiently in leaves and roots under salt stress, whereas expression level of BvSHMTb was not altered...
May 26, 2017: Protoplasma
https://www.readbyqxmd.com/read/28550416/optimal-suture-anchor-direction-in-arthroscopic-lateral-ankle-ligament-repair
#11
Ichiro Yoshimura, Tomonobu Hagio, Masahiro Noda, Kazuki Kanazawa, So Minokawa, Takuaki Yamamoto
PURPOSE: In this study, the distance between the insertion point of the suture anchors and posterior surface of the fibula during arthroscopic lateral ankle ligament repair was investigated on computed tomography (CT) images. The hypothesis of this study was that there is an optimal insertional direction of the suture anchor to avoid anchor-related complications. METHODS: One hundred eleven ankles of 98 patients who had undergone three-dimensional CT scans for foot or ankle disorders without deformity of the fibula were assessed (59 males, 52 females; median age 25...
May 26, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28550405/projective-biomechanical-depth-matching-for-soft-tissue-registration-in-laparoscopic-surgery
#12
Daniel Reichard, Dominik Häntsch, Sebastian Bodenstedt, Stefan Suwelack, Martin Wagner, Hannes Kenngott, Beat Müller-Stich, Lena Maier-Hein, Rüdiger Dillmann, Stefanie Speidel
PURPOSE: A key component of computer- assisted surgery systems is the accurate and robust registration of preoperative planning data with intraoperative sensor data. In laparoscopic surgery, this image-based registration remains challenging due to soft tissue deformations. This paper presents a novel approach for biomechanical soft tissue registration of preoperative CT data with stereo endoscopic image data. METHODS: The proposed method consists of two registrations steps...
May 26, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28550358/visualization-of-a-cam-type-femoroacetabular-impingement-while-squatting-using-image-matching-techniques-a-case-report
#13
Kensei Yoshimoto, Satoshi Hamai, Hidehiko Higaki, Hirotaka Gondoh, Yasuharu Nakashima
The in vivo assessment of the three-dimensional (3D) kinematics of the hip in patients with femoroacetabular impingement (FAI) under weight-bearing conditions has not been previously reported. We evaluated the pre- and postoperative hip kinematics of a 34-year-old man, with a cam-type FAI while squatting, using image-matching techniques with measurement of the rim-neck distance. Post-osteochondroplasty, the α-angle improved from 51.0° to 35.5° and the head-neck offset ratio from 0.04 to 0.23. Coxalgia during squatting disappeared, and the Harris Hip Score improved from 79 to 92 at 1 year post-surgery...
May 27, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28550346/differential-microvascular-assessment-of-retinal-vein-occlusion-with-coherence-tomography-angiography-and-fluorescein-angiography-a-blinded-comparative-study
#14
Chung Yee Chung, Heather Hoi Yau Tang, Siu Hung Li, Kenneth Kai Wang Li
PURPOSE: To compare the imaging of retinal vein occlusion (RVO) with optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) and evaluate their roles in clinical management. METHODS: RVO patients who underwent imaging with both FA and OCTA from 1 June 2015-31 December 2015 were enrolled. An independent retinal specialist blinded from patient identity assessed the FA and OCTA reports. The pixel counting technique was used for FAZ size measurement...
May 26, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28550154/an-amperometric-h2o2biosensor-based-on-hemoglobin-nanoparticles-immobilized-onto-a-gold-electrode
#15
Vinay Narwal, Neelam Yadav, Manisha Thakur, Chandra Shekhar Pundir
The nanoparticles (NPs) of hemoglobin (Hb) were prepared by desolvation method and characterized by transmission electron microscopy (TEM), ultraviolet (UV) spectroscopy and Fourier-transform infrared spectroscopy (FTIR). An amperometric H2O2 biosensor was constructed by immobilizing HbNPs covalently onto a polycrystalline Au electrode (AuE). HbNPs/AuE was characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectra (EIS) before and after immobilization of HbNPs...
May 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28550023/the-super-study-protocol-for-a-randomised-controlled-trial-comparing-follicle-stimulating-hormone-and-clomiphene-citrate-for-ovarian-stimulation-in-intrauterine-insemination
#16
N A Danhof, M van Wely, Cam Koks, J Gianotten, J P de Bruin, B J Cohlen, D P van der Ham, N F Klijn, Mha van Hooff, Fjm Broekmans, K Fleischer, Cah Janssen, J M Rijn van Weert, J van Disseldorp, M Twisk, M Traas, Mfg Verberg, M J Pelinck, J Visser, Dam Perquin, DES Boks, H R Verhoeve, C F van Heteren, Bwj Mol, S Repping, F van der Veen, M H Mochtar
OBJECTIVE: To study the effectiveness of four cycles of intrauterine insemination (IUI) with ovarian stimulation (OS) by follicle-stimulating hormone (FSH) or by clomiphene citrate (CC), and adherence to strict cancellation criteria. SETTING: Randomised controlled trial among 22 secondary and tertiary fertility clinics in the Netherlands. PARTICIPANTS: 732 women from couples diagnosed with unexplained or mild male subfertility and an unfavourable prognosis according to the model of Hunault of natural conception...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28549906/using-potentiometric-free-drug-sensors-to-determine-the-free-concentration-of-ionisable-drugs-in-colloidal-systems
#17
Thuy Tran, Anjan Chakraborty, Xi Xi, Hugo Bohets, Claus Cornett, Konstantin Tsinman, Thomas Rades, Anette Müllertz
The current study investigates the use of free drug sensors (FDS) to measure free ionized drug concentrations in colloidal systems, including micellar solutions and emulsions and lipid formulations during in vitro lipolysis. Diphenhydramine hydrochloride (DPH) and loperamide hydrochloride (LOP) were selected as model drugs. Self-diffusion nuclear magnetic resonance (NMR) studies were performed and confirmed the entrapment of drugs in micelles in Brij 35 and sodium taurodeoxycholate (TDC)/phosphatidylcholine (PC) micellar solutions...
May 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28549851/identification-of-pathway-based-prognostic-gene-signatures-in-patients-with-multiple-myeloma
#18
Mohamad Zamani-Ahmadmahmudi, Shahreyar Dabiri, Nadia Nadimi
Molecular profiling is used to extract prognostic gene signatures in different cancers such as multiple myeloma (MM), which is the second most common hematological malignancy. In this study, we utilized gene expression profiles to find biological pathways that could efficiently predict survival time in patients with MM. Four data sets-namely GSE2658 (559 samples), GSE9782 (264 samples), GSE6477 (147 samples), and GSE57317 (55 samples)-were employed. GSE2658 was used as a training data set and the others as validation data sets...
May 9, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28549715/direct-residue-analysis-of-systemic-insecticides-and-some-of-their-relevant-metabolites-in-wines-by-liquid-chromatography-mass-spectrometry
#19
J D Berset, S Mermer, A E Robel, V M Walton, M L Chien, J A Field
A direct large volume injection (DI-LVI) high performance liquid chromatography - tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the quantitative determination of 16 systemic insecticides and their main plant metabolites. The assays were conducted on commercial red and white wines made from grapes grown in major wine-producing regions nationally and internationally. Using a 1:20 dilution and an injection volume of 800μL, a limit of quantitation (LOQ) of 1μgL(-1) for all analytes was achieved...
May 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28549665/effects-of-supervised-exercise-and-dietary-nitrate-in-older-adults-with-controlled-hypertension-and-or-heart-failure-with-preserved-ejection-fraction
#20
Hossam A Shaltout, Joel Eggebeen, Anthony P Marsh, Peter H Brubaker, Paul J Laurienti, Jonathan H Burdette, Swati Basu, Ashley Morgan, Patricia C Dos Santos, James L Norris, Timothy M Morgan, Gary D Miller, W Jack Rejeski, Amret T Hawfield, Debra I Diz, J Thomas Becton, Daniel B Kim-Shapiro, Dalane W Kitzman
Aerobic exercise training is an effective therapy to improve peak aerobic power (peak VO2) in individuals with hypertension (HTN, AHA/ACC class A) and heart failure patients with preserved ejection fraction (HFpEF). High nitrate containing beetroot juice (BRJ) also improves sub-maximal endurance and decreases blood pressure in both HTN and HFpEF. We hypothesized that combining an aerobic exercise and dietary nitrate intervention would result in additive or even synergistic positive effects on exercise tolerance and blood pressure in HTN or HFpEF...
May 23, 2017: Nitric Oxide: Biology and Chemistry
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