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https://www.readbyqxmd.com/read/29337695/automated-fabrication-of-photopatterned-gelatin-hydrogels-for-organ-on-chips-applications
#1
Janna C Nawroth, Lisa L Scudder, Ryan T Halvorson, Jason Tresback, John P Ferrier, Sean P Sheehy, Alex Cho, Suraj Kannan, Ilona Sunyovszki, Josue A Goss, Patrick H Campbell, Kevin Kit Parker
Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micropatterned substrates, which limits turnover and flexibility of prototyping. We present a rapid and automated method for large scale on-demand micropatterning of gelatin hydrogels for organ-on-chip applications using a novel biocompatible laser-etching approach...
January 16, 2018: Biofabrication
https://www.readbyqxmd.com/read/29302489/enhancing-breast-projection-in-autologous-reconstruction-using-the-st-andrew-s-coning-technique-and-3d-volumetric-analysis
#2
Michael P Chae, Warren Matthew Rozen, Nakul Gamanlal Patel, David J Hunter-Smith, Venkat Ramakrishnan
Background: An increasing number of women undergo mastectomy for breast cancer and post-mastectomy autologous breast reconstruction has been shown to significantly improve the psychosexual wellbeing of the patients. A goal of treatment is to achieve symmetry and projection to match the native breast, and/or the contralateral breast in the case of a unilateral reconstruction. Autologous reconstruction, particularly with the deep inferior epigastric artery perforator (DIEP) flap, is particularly advantageous as it can be manipulated to mimic the shape and turgor of the native breast...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29300411/customizing-polyelectrolyte-complex-shapes-through-photolithographic-directed-assembly
#3
Udaka K de Silva, Kunal Choudhuri, Amanda C Bryant-Friedrich, Yakov Lapitsky
Polyelectrolyte complexes (PECs) form through the association of oppositely charged polymers and, due to their attractive properties, such as their mild/simple preparation and stimulus-sensitivity, attract widespread interest. The diverse applications of these materials often require control over PEC shapes. As a versatile approach to achieving such control, we report a new photolithographic directed assembly method for tailoring their structure. This method uses aqueous solutions of a polyelectrolyte, an oppositely charged monomer and a photoinitiator...
January 4, 2018: Soft Matter
https://www.readbyqxmd.com/read/29282550/bioactive-calcium-silicate-poly-%C3%AE%C2%B5-caprolactone-composite-scaffolds-3d-printed-under-mild-conditions-for-bone-tissue-engineering
#4
Yen-Hong Lin, Yung-Cheng Chiu, Yu-Fang Shen, Yuan-Haw Andrew Wu, Ming-You Shie
The present study provides a solvent-free processing method for establishing the ideal porous 3-dimension (3D) scaffold filled with different ratios of calcium silicate-based (CS) powder and polycaprolactone (PCL) for 3D bone substitute application. Characterization of hybrid scaffolds developed underwent assessments for physicochemical properties and biodegradation. Adhesion and growth of human Wharton's Jelly mesenchymal stem cells (WJMSCs) on the CS/PCL blended scaffold were investigated in vitro. Cell attachment and morphology were examined by scanning electron microscope (SEM) and confocal microscope observations...
December 27, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29124128/vascular-deformation-mapping-vdm-of-thoracic-aortic-enlargement-in-aneurysmal-disease-and-dissection
#5
Nicholas S Burris, Benjamin A Hoff, Ella A Kazerooni, Brian D Ross
Thoracic aortic aneurysm is a common and lethal disease that requires regular imaging surveillance to determine timing of surgical repair and prevent major complications such as rupture. Current cross-sectional imaging surveillance techniques, largely based on computed tomography angiography, are focused on measurement of maximal aortic diameter, although this approach is limited to fixed anatomic positions and is prone to significant measurement error. Here we present preliminary results showing the feasibility of a novel technique for assessing change in aortic dimensions, termed vascular deformation mapping (VDM)...
September 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29110921/3d-printed-versus-conventionally-cured-provisional-crown-and-bridge-dental-materials
#6
Anthony Tahayeri, MaryCatherine Morgan, Ana P Fugolin, Despoina Bompolaki, Avathamsa Athirasala, Carmem S Pfeifer, Jack L Ferracane, Luiz E Bertassoni
OBJECTIVES: To optimize the 3D printing of a dental material for provisional crown and bridge restorations using a low-cost stereolithography 3D printer; and compare its mechanical properties against conventionally cured provisional dental materials. METHODS: Samples were 3D printed (25×2×2mm) using a commercial printable resin (NextDent C&B Vertex Dental) in a FormLabs1+ stereolithography 3D printer. The printing accuracy of printed bars was determined by comparing the width, length and thickness of samples for different printer settings (printing orientation and resin color) versus the set dimensions of CAD designs...
October 27, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29068429/3-axis-fully-integrated-capacitive-tactile-sensor-with-flip-bonded-cmos-on-ltcc-interposer
#7
Sho Asano, Masanori Muroyama, Takahiro Nakayama, Yoshiyuki Hata, Yutaka Nonomura, Shuji Tanaka
This paper reports a 3-axis fully integrated differential capacitive tactile sensor surface-mountable on a bus line. The sensor integrates a flip-bonded complementary metal-oxide semiconductor (CMOS) with capacitive sensing circuits on a low temperature cofired ceramic (LTCC) interposer with Au through vias by Au-Au thermo-compression bonding. The CMOS circuit and bonding pads on the sensor backside were electrically connected through Au bumps and the LTCC interposer, and the differential capacitive gap was formed by an Au sealing frame...
October 25, 2017: Sensors
https://www.readbyqxmd.com/read/29020507/custom-repair-of-mandibular-bone-defects-with-3d-printed-bioceramic-scaffolds
#8
H Shao, M Sun, F Zhang, A Liu, Y He, J Fu, X Yang, H Wang, Z Gou
Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular defects in macro and micro, were manufactured by the 3-dimensional (3D) printing technique according to the computed tomography (CT) image. To evaluate the stimulatory effect of the material substrate on bone tissue regeneration in situ in a rabbit mandibular alveolar bone defect model, implants made with the newly developed, mechanically strong ~10% Mg-substituted wollastonite (Ca90%Mg10%SiO3; CSi-Mg10) were fabricated, implanted into the bone defects, and compared with implants made with the typical Ca-phosphate and Ca-silicate porous bioceramics, such as β-tricalcium phosphate (TCP), wollastonite (CaSiO3; CSi), and bredigite (Bred)...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28977423/three-dimensional-printed-models-for-surgical-planning-of-complex-congenital-heart-defects-an-international-multicentre-study
#9
Israel Valverde, Gorka Gomez-Ciriza, Tarique Hussain, Cristina Suarez-Mejias, Maria N Velasco-Forte, Nicholas Byrne, Antonio Ordoñez, Antonio Gonzalez-Calle, David Anderson, Mark G Hazekamp, Arno A W Roest, Jose Rivas-Gonzalez, Sergio Uribe, Issam El-Rassi, John Simpson, Owen Miller, Enrique Ruiz, Ignacio Zabala, Ana Mendez, Begoña Manso, Pastora Gallego, Freddy Prada, Massimiliano Cantinotti, Lamia Ait-Ali, Carlos Merino, Andrew Parry, Nancy Poirier, Gerald Greil, Reza Razavi, Tomas Gomez-Cia, Amir-Reza Hosseinpour
OBJECTIVES: To evaluate the impact of 3D printed models (3D models) on surgical planning in complex congenital heart disease (CHD). METHODS: A prospective case-crossover study involving 10 international centres and 40 patients with complex CHD (median age 3 years, range 1 month-34 years) was conducted. Magnetic resonance imaging and computed tomography were used to acquire and segment the 3D cardiovascular anatomy. Models were fabricated by fused deposition modelling of polyurethane filament, and dimensions were compared with medical images...
December 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28930824/evaluating-the-morphology-of-the-left-atrial-appendage-by-a-transesophageal-echocardiographic-3-dimensional-printed-model
#10
Hongning Song, Qing Zhou, Lan Zhang, Qing Deng, Yijia Wang, Bo Hu, Tuantuan Tan, Jinling Chen, Yiteng Pan, Fazhi He
The novel 3-dimensional printing (3DP) technique has shown its ability to assist personalized cardiac intervention therapy. This study aimed to determine the feasibility of 3D-printed left atrial appendage (LAA) models based on 3D transesophageal echocardiography (3D TEE) data and their application value in treating LAA occlusions.Eighteen patients with transcatheter LAA occlusion, and preprocedure 3D TEE and cardiac computed tomography were enrolled. 3D TEE volumetric data of the LAA were acquired and postprocessed for 3DP...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28905390/validation-of-the-gatortail-method-for-accurate-sizing-of-pulmonary-vessels-from-3d-medical-images
#11
Walter G O'Dell, Anne K Gormaley, David A Prida
PURPOSE: Detailed characterization of changes in vessel size is crucial for the diagnosis and management of a variety of vascular diseases. Because clinical measurement of vessel size is typically dependent on the radiologist's subjective interpretation of the vessel borders, it is often prone to high inter- and intra-user variability. Automatic methods of vessel sizing have been developed for two-dimensional images but a fully three-dimensional (3D) method suitable for vessel sizing from volumetric X-ray computed tomography (CT) or magnetic resonance imaging has heretofore not been demonstrated and validated robustly...
September 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28741361/three-dimensional-printed-shape-memory-objects-based-on-an-olefin-ionomer-of-zinc-neutralized-poly-ethylene-co-methacrylic-acid
#12
Zhiyang Zhao, Fang Peng, Kevin A Cavicchi, Mukerrem Cakmak, R A Weiss, Bryan D Vogt
Three-dimensional printing enables the net shape manufacturing of objects with minimal material waste and low tooling costs, but the functionality is generally limited by available materials, especially for extrusion-based printing, such as fused deposition modeling (FDM). Here, we demonstrate shape memory behavior of 3D printed objects with FDM using a commercially available olefin ionomer, Surlyn 9520, which is zinc-neutralized poly(ethylene-co-methacrylic acid). The initial fixity for 3D printed and compression-molded samples was similar, but the initial recovery was much lower for the 3D printed sample (R = 58%) than that for the compression-molded sample (R = 83%)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28738005/accuracy-and-repeatability-of-long-bone-replicas-of-small-animals-fabricated-by-use-of-low-end-and-high-end-commercial-three-dimensional-printers
#13
Jamie A Cone, Thomas M Martin, Denis J Marcellin-Little, Ola L A Harrysson, Emily H Griffith
OBJECTIVE To assess the repeatability and accuracy of polymer replicas of small, medium, and large long bones of small animals fabricated by use of 2 low-end and 2 high-end 3-D printers. SAMPLE Polymer replicas of a cat femur, dog radius, and dog tibia were fabricated in triplicate by use of each of four 3-D printing methods. PROCEDURES 3-D renderings of the 3 bones reconstructed from CT images were prepared, and length, width of the proximal aspect, and width of the distal aspect of each CT image were measured in triplicate...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28686415/high-resolution-transfer-printing-of-graphene-lines-for-fully-printed-flexible-electronics
#14
Donghoon Song, Ankit Mahajan, Ethan B Secor, Mark C Hersam, Lorraine F Francis, C Daniel Frisbie
Pristine graphene inks show great promise for flexible printed electronics due to their high electrical conductivity and robust mechanical, chemical, and environmental stability. While traditional liquid-phase printing methods can produce graphene patterns with a resolution of ∼30 μm, more precise techniques are required for improved device performance and integration density. A high-resolution transfer printing method is developed here capable of printing conductive graphene patterns on plastic with line width and spacing as small as 3...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28648046/a-printed-equilibrium-dialysis-device-with-integrated-membranes-for-improved-binding-affinity-measurements
#15
Cody W Pinger, Andrew A Heller, Dana M Spence
Equilibrium dialysis is a simple and effective technique used for investigating the binding of small molecules and ions to proteins. A three-dimensional (3D) printer was used to create a device capable of measuring binding constants between a protein and a small ion based on equilibrium dialysis. Specifically, the technology described here enables the user to customize an equilibrium dialysis device to fit their own experiments by choosing membranes of various material and molecular-weight cutoff values. The device has dimensions similar to that of a standard 96-well plate, thus being amenable to automated sample handlers and multichannel pipettes...
July 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28637730/the-relationship-between-physician-burnout-and-quality-of-healthcare-in-terms-of-safety-and-acceptability-a-systematic-review
#16
Carolyn S Dewa, Desmond Loong, Sarah Bonato, Lucy Trojanowski
OBJECTIVES: This study reviews the current state of the published peer-reviewed literature related to physician burnout and two quality of care dimensions. The purpose of this systematic literature review is to address the question, 'How does physician burnout affect the quality of healthcare related to the dimensions of acceptability and safety?' DESIGN: Using a multiphase screening process, this systematic literature review is based on publically available peer-reviewed studies published between 2002 and 2017...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28598001/3d-printing-technology-in-planning-thumb-reconstructions-with-second-toe-transplant
#17
Cheng-Wu Zang, Jian-Lei Zhang, Ze-Zu Meng, Lin-Feng Liu, Wen-Zhi Zhang, Yong-Xiang Chen, Rui Cong
OBJECTIVE: To report preoperative planning using 3D printing to plan thumb reconstructions with second toe transplant. METHODS: Between December 2013 and October 2015, the thumbs of five patients with grade 3 thumb defects were reconstructed using a wrap-around flap and second toe transplant aided by 3D printing technology. CT scans of hands and feet were analyzed using Boholo surgical simulator software (www.boholo.com). This allowed for the creation of a mirror image of the healthy thumb using the uninjured thumb...
May 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28584469/pattern-self-repetition-of-fingerprints-lip-prints-and-palatal-rugae-among-three-generations-of-family-a-forensic-approach-to-identify-family-hierarchy
#18
Sankeerti Mala, Vanita Rathod, Siddharth Pundir, Sudhanshu Dixit
CONTEXT: The unique pattern and structural diversity of fingerprints, lip prints, palatal rugae, and their occurrence in different patterns among individuals make it questionable whether they are completely unique even in a family hierarchy? Do they have any repetition of the patterns among the generations? Or is this a mere chaos theory? AIMS: The present study aims to assess the pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of ten different families...
January 2017: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28554463/accuracy-of-printed-dental-models-made-with-2-prototype-technologies-and-different-designs-of-model-bases
#19
Leonardo Tavares Camardella, Oswaldo de Vasconcellos Vilella, Hero Breuning
INTRODUCTION: The aim of this study was to compare the accuracy of printed models from intraoral scans with different designs of model bases, using 2 types of 3-dimensional printing techniques. METHODS: Three types of model base design were created: regular base, horseshoe-shaped base, and horseshoe-shaped base with a bar connecting the posterior region. The digital models were printed with the 3-dimensional printers using different techniques: stereolithography and triple jetting technology (polyjet)...
June 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28441229/preliminary-model-for-the-design-of-a-custom-middle-ear-prosthesis
#20
Brandon Kamrava, Jonathan A Gerstenhaber, Mamta Amin, Yah-El Har-El, Pamela C Roehm
HYPOTHESIS: Custom prostheses could be used to recreate the ossicular chain and improve hearing. BACKGROUND: Ossicular discontinuity or fixation occurs in 55% of cases of conductive hearing loss, with most cases involving the incus. Reconstruction has been achieved by a variety of methods; however, there has been little improvement in hearing outcomes in decades. METHODS: Precise measurements of anatomic dimensions, weight, and center of gravity were taken from 19 cadaveric incudes...
July 2017: Otology & Neurotology
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