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Susan E Collins, Victoria E Orfaly, Teresa Wu, Sunny Chang, Robert V Hardy, Amia Nash, Matthew B Jones, Leslie Mares, Emily M Taylor, Lonnie A Nelson, Seema L Clifasefi
BACKGROUND: Cigarette smoking is 5 times more prevalent among homeless individuals than in the general population, and homeless individuals are disproportionately affected by smoking-related morbidity and mortality. Homeless smokers report interest in changing their smoking behavior; however, established smoking cessation interventions are neither desirable to nor highly effective for most members of this population. The aim of this study was to document homeless smokers' perceptions of established smoking interventions as well as self-generated, alternative smoking interventions to elucidate points for intervention enhancement...
November 13, 2017: International Journal on Drug Policy
B L Massoudi, K G Chester
Objectives: To survey advances in public and population health and epidemiology informatics over the past 18 months. Methods: We conducted a review of English-language research works conducted in the domain of public and population health informatics and published in MEDLINE or Web of Science between January 2015 and June 2016 where information technology or informatics was a primary subject or main component of the study methodology. Selected articles were presented using a thematic analysis based on the 2011 American Medical Informatics Association (AMIA) Public Health Informatics Agenda tracks as a typology...
August 2017: Yearbook of Medical Informatics
L Nelson Sanchez-Pinto, Abu S M Mosa, Kate Fultz-Hollis, Umberto Tachinardi, William K Barnett, Peter J Embi
BACKGROUND: The role of the Chief Research Informatics Officer (CRIO) is emerging in academic health centers to address the challenges clinical researchers face in the increasingly digitalized, data-intensive healthcare system. Most current CRIOs are the first officers in their institutions to hold that role. To date there is very little published information about this role and the individuals who serve it. OBJECTIVE: To increase our understanding of the CRIO role, the leaders who serve it, and the factors associated with their success in their organizations...
August 16, 2017: Applied Clinical Informatics
Jun Liang, Kunyan Wei, Qun Meng, Zhenying Chen, Jiajie Zhang, Jianbo Lei
BACKGROUND: China launched its second health reform in 2010 with considerable investments in medical informatics (MI). However, to the best of our knowledge, research on the outcomes of this ambitious undertaking has been limited. OBJECTIVE: Our aim was to understand the development of MI and the state of continuing education in China and the United States from the perspective of conferences. METHODS: We conducted a quantitative and qualitative analysis of four MI conferences in China and two in the United States: China Medical Information Association Annual Symposium (CMIAAS), China Hospital Information Network Annual Conference (CHINC), China Health Information Technology Exchange Annual Conference (CHITEC), China Annual Proceeding of Medical Informatics (CPMI) versus the American Medical Informatics Association (AMIA) and Healthcare Information and Management Systems Society (HIMSS)...
June 21, 2017: Journal of Medical Internet Research
Florian Witzmann, Ingmar Werneburg
A diagnostic feature of temnospondyls is the presence of an open palate with large interpterygoid vacuities, unlike the closed palate of most other early tetrapods, in which the vacuities are either slit-like or completely absent. Attachment sites on neurocranium and palatal bones in temnospondyls allow the reconstruction of a powerful m. retractor bulbi and a large, sheet-like m. levator bulbi that formed the elastic floor of the orbit. This muscle arrangement indicates that temnospondyls were able to retract the eyeballs through the interpterygoid vacuities into the buccal cavity, like extant frogs and salamanders...
February 21, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Papa Ibnou Ndiaye, Yann Quilichini, Adji Mama Marigo, Cheikh Tidiane Bâ, Vasyl V Tkach, Bernard Marchand
The mature spermatozoon of Sclerodistomum italicum is filiform, tapered at both ends and shows the following features: 2 axonemes of the 9+"1" pattern of the Trepaxonemata, mitochondrion, nucleus and parallel cortical microtubules. The specific features of the spermatozoon of S. italicum include the simultaneous presence of two types of extramembranous ornamentations, the presence of short cortical microtubules in the anterior part of the spermatozoon and the presence of only one bundle of cortical microtubules in the median part of the spermatozoon...
February 2017: Tissue & Cell
Zuzana Majtánová, Radka Symonová, Lenin Arias-Rodriguez, Lauren Sallan, Petr Ráb
Bowfin belongs to an ancient lineage of nonteleost ray-finned fishes (actinopterygians) and is the only extant survivor of a once diverged group, the Halecomorphi or Amiiformes. Owing to the scarcity of extant nonteleost ray-finned lineages, also referred as "living fossils," their phylogenetic interrelationships have been the target of multiple hypotheses concerning their sister group relationships. Molecular and morphological data sets have produced controversial results; bowfin is considered as either the sister group to genome-duplicated teleosts (together forming the group of Halecostomi) or to gars (Lepisosteiformes; together forming the group of Holostei)...
November 2017: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
Kirk Roberts, Mary Regina Boland, Lisiane Pruinelli, Jina Dcruz, Andrew Berry, Mattias Georgsson, Rebecca Hazen, Raymond F Sarmiento, Uba Backonja, Kun-Hsing Yu, Yun Jiang, Patricia Flatley Brennan
The field of biomedical informatics experienced a productive 2015 in terms of research. In order to highlight the accomplishments of that research, elicit trends, and identify shortcomings at a macro level, a 19-person team conducted an extensive review of the literature in clinical and consumer informatics. The result of this process included a year-in-review presentation at the American Medical Informatics Association Annual Symposium and a written report (see supplemental data). Key findings are detailed in the report and summarized here...
April 1, 2017: Journal of the American Medical Informatics Association: JAMIA
Catherine Chaput, Chantal Ecobichon, Nadine Pouradier, Jean-Claude Rousselle, Abdelkader Namane, Ivo G Boneca
The human gastric pathogen, Helicobacter pylori, is becoming increasingly resistant to most available antibiotics. Peptidoglycan (PG) metabolism is essential to eubacteria, hence, an excellent target for the development of new therapeutic strategies. However, our knowledge on PG metabolism in H. pylori remains poor. We have further characterized an isogenic mutant of the amiA gene encoding a N-acetylmuramoyl-l-alanyl amidase. The amiA mutant displayed long chains of unseparated cells, an impaired motility despite the presence of intact flagella and a tolerance to amoxicillin...
September 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Cynthia S Gadd, Jeffrey J Williamson, Elaine B Steen, Katherine P Andriole, Connie Delaney, Karl Gumpper, Martin LaVenture, Doug Rosendale, Dean F Sittig, Thankam Thyvalikakath, Peggy Turner, Douglas B Fridsma
AMIA is leading the effort to strengthen the health informatics profession by creating an advanced health informatics certification (AHIC) for individuals whose informatics work directly impacts the practice of health care, public health, or personal health. The AMIA Board of Directors has endorsed a set of proposed AHIC eligibility requirements that will be presented to the future AHIC certifying entity for adoption. These requirements specifically establish who will be eligible to sit for the AHIC examination and more generally signal the depth and breadth of knowledge and experience expected from certified individuals...
July 2016: Journal of the American Medical Informatics Association: JAMIA
Cynthia S Gadd, Jeffrey J Williamson, Elaine B Steen, Douglas B Fridsma
In 2005, AMIA leaders and members concluded that certification of advanced health informatics professionals would offer value to individual practitioners, organizations that hire them, and society at large. AMIA's work to create advanced informatics certification began by leading a successful effort to create the clinical informatics subspecialty for American Board of Medical Specialties board-certified physicians. Since 2012, AMIA has been working to establish advanced health informatics certification (AHIC) for all health informatics practitioners regardless of their primary discipline...
July 2016: Journal of the American Medical Informatics Association: JAMIA
Susan K Newbold, Juliana J Brixey
The American Medical Informatics Association (AMIA) established the Nursing Informatics History Project to recognize the pioneers of nursing informatics. Fundamental to the pioneers was dissemination of knowledge. The purpose of this review was to identify contributions to the field of nursing informatics as peer-reviewed manuscripts for the years 2010-2015 and indexed in PubMed. Results indicate that many of the pioneers continue to have manuscripts indexed in PubMed. It is anticipated this project will be extended to identify other types of contributions made by the pioneers in the advancement of nursing informatics...
2016: Studies in Health Technology and Informatics
Annette L Valenta, Emma A Meagher, Umberto Tachinardi, Justin Starren
Since the inception of the Clinical and Translational Science Award (CTSA) program in 2006, leaders in education across CTSA sites have been developing and updating core competencies for Clinical and Translational Science (CTS) trainees. By 2009, 14 competency domains, including biomedical informatics, had been identified and published. Since that time, the evolution of the CTSA program, changes in the practice of CTS, the rapid adoption of electronic health records (EHRs), the growth of biomedical informatics, the explosion of big data, and the realization that some of the competencies had proven to be difficult to apply in practice have made it clear that the competencies should be updated...
July 2016: Journal of the American Medical Informatics Association: JAMIA
Miguel Peña-Espinoza, Ulrik Boas, Andrew R Williams, Stig M Thamsborg, Henrik T Simonsen, Heidi L Enemark
The study investigated direct anthelmintic effects of sesquiterpene lactones (SL)-containing extracts from forage chicory against free-living and parasitic stages of Ostertagia ostertagi. Freeze-dried leaves from chicory cultivars 'Spadona' and 'Puna II' were extracted using methanol/water. Total SL were further fractionated by solid-phase extraction and resulting extracts were characterised by high-performance liquid chromatography (HPLC). O. ostertagi eggs from faeces of mono-infected calves were hatched and L1 were used in a larval feeding inhibition assay (LFIA), while cultured L3 were used in a larval exsheathment inhibition assay (LEIA)...
December 2015: International Journal for Parasitology, Drugs and Drug Resistance
Joseph Kannry, Patricia Sengstack, Thankam Paul Thyvalikakath, John Poikonen, Blackford Middleton, Thomas Payne, Christoph U Lehmann
INTRODUCTION: The emerging operational role of the "Chief Clinical Informatics Officer" (CCIO) remains heterogeneous with individuals deriving from a variety of clinical settings and backgrounds. The CCIO is defined in title, responsibility, and scope of practice by local organizations. The term encompasses the more commonly used Chief Medical Informatics Officer (CMIO) and Chief Nursing Informatics Officer (CNIO) as well as the rarely used Chief Pharmacy Informatics Officer (CPIO) and Chief Dental Informatics Officer (CDIO)...
2016: Applied Clinical Informatics
Kim M Unertl, John T Finnell, Indra Neil Sarkar
Increasing access to biomedical informatics experiences is a significant need as the field continues to face workforce challenges. Looking beyond traditional medical school and graduate school pathways into the field is crucial for expanding the number of individuals and increasing diversity in the field. This case report provides an overview of the development and initial implementation of the American Medical Informatics Association (AMIA) High School Scholars Program. Initiated in 2014, the program's primary goal was to provide dissemination opportunities for high school students engaged in biomedical informatics research...
July 2016: Journal of the American Medical Informatics Association: JAMIA
Montserrat Palau, Marcos Kulmann, María José Ramírez-Lázaro, Sergio Lario, María Elisa Quilez, Rafael Campo, Núria Piqué, Xavier Calvet, David Miñana-Galbis
BACKGROUND: Helicobacter pylori infects human stomachs of over half the world's population, evades the immune response and establishes a chronic infection. Although most people remains asymptomatic, duodenal and gastric ulcers, MALT lymphoma and progression to gastric cancer could be developed. Several virulence factors such as flagella, lipopolysaccharide, adhesins and especially the vacuolating cytotoxin VacA and the oncoprotein CagA have been described for H. pylori. Despite the extensive published data on H...
December 2016: Helicobacter
Jonathan D Lenz, Elizabeth A Stohl, Rosanna M Robertson, Kathleen T Hackett, Kathryn Fisher, Kalia Xiong, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, H Steven Seifert, Christopher Davies, Joseph P Dillard
The human-restricted pathogen Neisseria gonorrhoeae encodes a single N-acetylmuramyl-l-alanine amidase involved in cell separation (AmiC), as compared with three largely redundant cell separation amidases found in Escherichia coli (AmiA, AmiB, and AmiC). Deletion of amiC from N. gonorrhoeae results in severely impaired cell separation and altered peptidoglycan (PG) fragment release, but little else is known about how AmiC functions in gonococci. Here, we demonstrated that gonococcal AmiC can act on macromolecular PG to liberate cross-linked and non-cross-linked peptides indicative of amidase activity, and we provided the first evidence that a cell separation amidase can utilize a small synthetic PG fragment as substrate (GlcNAc-MurNAc(pentapeptide)-GlcNAc-MurNAc(pentapeptide))...
May 13, 2016: Journal of Biological Chemistry
Alexa T McCray, John Glaser, Ross Koppel, Curtis P Langlotz, Jonathan Silverstein
The American College of Medical Informatics (ACMI) periodically hosts a debate at the American Medical Informatics Association (AMIA) fall symposium on a timely topic in biomedical informatics. In 2014 a panel of ACMI fellows debated the following proposition: "The lack of interaction and collaboration between health IT vendors and academic clinical informatics units is stifling innovation and will continue to have a detrimental effect on the evolution of commercial products." Debaters disagreed on the level of interaction and collaboration between the health IT sector and academia and disagreed on whether and by whom innovation was actually taking place...
April 2016: Journal of Biomedical Informatics
Laura K Wiley, Peter Tarczy-Hornoch, Joshua C Denny, Robert R Freimuth, Casey L Overby, Nigam Shah, Ross D Martin, Indra Neil Sarkar
The American Medical Informatics Association convened the 2014 Health Policy Invitational Meeting to develop recommendations for updates to current policies and to establish an informatics research agenda for personalizing medicine. In particular, the meeting focused on discussing informatics challenges related to personalizing care through the integration of genomic or other high-volume biomolecular data with data from clinical systems to make health care more efficient and effective. This report summarizes the findings (n = 6) and recommendations (n = 15) from the policy meeting, which were clustered into 3 broad areas: (1) policies governing data access for research and personalization of care; (2) policy and research needs for evolving data interpretation and knowledge representation; and (3) policy and research needs to ensure data integrity and preservation...
March 2016: Journal of the American Medical Informatics Association: JAMIA
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