Guodong Chai, Ning Wang, Meiling Xu, Lina Ma, Xinglong Liu, Qiteng Ding, Shuai Zhang, Anning Li, Guofeng Xia, Yingchun Zhao, Wencong Liu, Dadong Liang, Chuanbo Ding
Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO2 ), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H2 O2 ) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H2 O2 to the cells during the oxygen-releasing process...
April 19, 2024: International Journal of Biological Macromolecules