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https://www.readbyqxmd.com/read/29159844/incidence-and-predictors-of-30-day-postoperative-readmission-in-children
#1
Daniel Vo, David Zurakowski, David Faraoni
BACKGROUND: Hospital readmissions are being used as a quality metric for hospital reimbursement without a clear understanding of the factors that contribute to readmission. OBJECTIVE: The objective of this study was to report the incidence of 30-day postsurgical readmission in children, identify the predictors for readmission, and create an algorithm to identify high-risk children. METHODS: Data from the 2012-2014 Pediatric database of the American College of Surgeons National Surgical Quality Improvement Program were analyzed using univariable and multivariable logistical regression analysis...
November 20, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29159695/a-novel-lignin-based-nanofibrous-dressing-containing-arginine-for-wound-healing-applications
#2
Fatemeh Reesi, Mohsen Minaiyan, Azade Taheri
Nanofiber-based wound dressings have attracted much attention in wound care owing to their unique properties such as high aspect ratio and three-dimensional structure. Arginine is a precursor of nitric oxide that plays an important role in the wound-healing process. Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel). The effect of pH on the amount of arginine attached on Lig-NF surface was evaluated at three different pH values-5, 6, and 7...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29156159/amnion-the-ideal-scaffold-for-treating-full-thickness-wounds-of-the-lower-extremity
#3
REVIEW
Bryon McKenna, N Jake Summers
Amnion and amniotic tissue has been studied for more than 100 years in the treatment of acute and chronic wounds. Recent studies have focused on the use of amnion tissue in the management of full-thickness diabetic wounds, particularly of the lower extremities. With new harvesting, processing, and distribution technologies, amnion is increasingly available in treating these wounds. Current data and research show increased healing potential and decreased healing times, pain, drainage, and infection in wounds treated with amnion products...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29155834/measuring-the-microbiome-of-chronic-wounds-with-use-of-a-topical-antimicrobial-dressing-a-feasibility-study
#4
Lindsay Kalan, Mi Zhou, Michele Labbie, Benjamin Willing
BACKGROUND: Polymicrobial communities colonize all wounds, and biofilms are hypothesized to be a key link to the chronic state and stalled healing. Molecular methods offer greater insight when studying microbial ecology in chronic wounds, as only a small fraction of wound bacteria are cultured by currently available methods and studies have shown little agreement between culture and molecular based approaches. Some interventions, like dressings with oxidized silver, are reported to help the stalled wounds move to a normal healing trajectory but the underlying mechanisms are difficult to measure...
2017: PloS One
https://www.readbyqxmd.com/read/29155399/green-synthesis-of-anisotropic-gold-nanoparticles-using-hordenine-and-their-antibiofilm-efficacy-against-pseudomonas-aeruginosa
#5
Jobina Rajkumari, Himani Meena, Muralitharan Gangatharan, Siddhardha Busi
Pseudomonas aeruginosa is a notorious pathogen that causes biofilm aided infections in patients with cystic fibrosis and burn wounds, resulting in significant mortality in immunocompromised individuals. This study reports a novel one-step biosynthesis of gold nanoparticles using phytocompound, hordenine (HD), as a reducing and capping agent. The synthesis of the anisotropic hordenine-fabricated gold nanoparticles (HD-AuNPs) with an average particle size of 136.87 nm was achieved within 12 h of incubation at room temperature...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29155110/delayed-traumatic-aortic-pseudoaneurysm-formation-causing-vertebral-body-erosion-and-back-pain-case-report-and-literature-review
#6
Justin M Cappuzzo, Kathleen E Knudson, Shawn Sarin, Joseph Babrowicz, Abraham Cherrick, Jonathan H Sherman
BACKGROUND: Aortic pseudoaneurysms are a rare cause of chronic back pain, usually due to compression of adjacent neurovasculature. It is uncommon for patients with pseudoaneurysms of the abdominal aorta to present in a delayed fashion after initial traumatic injury. CASE DESCRIPTION: We present an unusual case of delayed pseudoaneurysm formation, with subsequent erosion into the adjacent L1 vertebral body. This pseudoaneurysm was secondary to a gunshot wound with retained ballistic fragment that occurred 27 years prior...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29154922/wound-care-center-of-excellence-guide-to-operative-technique-for-chronic-wounds
#7
Raelina S Howell, Scott Gorenstein, Michael Castellano, Eric Slone, Jon S Woods, Brian M Gillette, Virginia Donovan, Theresa Criscitelli, Harold Brem, Collin Brathwaite
No abstract text is available yet for this article.
November 14, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29151267/impaired-permeability-and-antimicrobial-barriers-in-type-2-diabetes-skin-are-linked-to-increased-serum-levels-of-advanced-glycation-end-product
#8
Jae-Hong Kim, Na Young Yoon, Dong Hye Kim, Minyoung Jung, Myungsoo Jun, Hwa-Young Park, Choon Hee Chung, Kyohoon Lee, Sunki Kim, Chang Seo Park, Kwang-Hyeon Liu, Eung Ho Choi
BACKGROUND: The incidence of type 2 diabetes mellitus (DM) has been increasing rapidly, and the disease has become a serious sociomedical problem. Many skin problems, such as xerosis, pruritus, skin infections, and delayed wound healing, that might be related to chronic impairment of skin barrier function decrease the quality of life in DM patients. However, the status of the permeability and antimicrobial barrier of the skin in DM remains unknown. OBJECTIVE: This study aimed to elucidate skin barrier impairment in type 2 DM patients and its patho-mechanisms using classic animal models of type 2 DM...
November 19, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29146967/splenic-glucocorticoid-resistance-following-psychosocial-stress-requires-physical-injury
#9
Sandra Foertsch, Andrea M Füchsl, Sandra D Faller, Hannah Hölzer, Dominik Langgartner, Joanna Messmann, Gudrun Strauß, Stefan O Reber
Mice exposed to chronic subordinate colony housing (CSC) stress show glucocorticoid (GC) resistance of in vitro lipopolysaccharide (LPS)-stimulated splenocytes, increased anxiety and colitis. Similar effects were reported in wounded mice exposed to social disruption (SDR). Here we show that CSC exposure induced GC resistance in isolated and in vitro LPS-stimulated, but not unstimulated, splenocytes, and these effects were absent when CD11b(+) splenocytes were depleted. Moreover, re-active coping behaviour during CSC correlated with the attacks and bites received by the resident, which in turn highly correlated with the dimension of splenic GC resistance, as with basal and LPS-induced in vitro splenocyte viability...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29145757/nutrition-and-lower-extremity-ulcers-causality-and-or-treatment
#10
Lauren Haughey, Adrian Barbul
The association between malnutrition, impaired wound healing, and the presence of chronic wounds has been recognized for a long time. It is widely believed that the lack of adequate nutrition increases the risk of developing wounds which have a great likelihood of progressing to chronicity due to lack of appropriate healing responses. This risk is particularly high in the aging population. For the individual patient, as well as patient populations, the diagnosis of malnutrition has been in dispute; further, there is lack of agreement of when and how to intervene nutritionally in those with wounds or healing deficits...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29144785/role-of-slough-and-biofilm-in-delaying-healing-in-chronic-wounds
#11
Heather Newton, Jacky Edwards, Louise Mitchell, Steven L Percival
The management of biofilms with maintenance desloughing and antimicrobial therapy is fast becoming the accepted treatment strategy for chronic wounds.
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29144448/regeneration-of-the-entire-human-epidermis-using-transgenic-stem-cells
#12
Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Johann W Bauer, Graziella Pellegrini, Laura De Rosa, Davide Scaglione, Julia Reichelt, Alfred Klausegger, Daniela Kneisz, Oriana Romano, Alessia Secone Seconetti, Roberta Contin, Elena Enzo, Irena Jurman, Sonia Carulli, Frank Jacobsen, Thomas Luecke, Marcus Lehnhardt, Meike Fischer, Maximilian Kueckelhaus, Daniela Quaglino, Michele Morgante, Silvio Bicciato, Sergio Bondanza, Michele De Luca
Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused by mutations in genes encoding the basement membrane component laminin-332. Surviving patients with JEB develop chronic wounds to the skin and mucosa, which impair their quality of life and lead to skin cancer. Here we show that autologous transgenic keratinocyte cultures regenerated an entire, fully functional epidermis on a seven-year-old child suffering from a devastating, life-threatening form of JEB. The proviral integration pattern was maintained in vivo and epidermal renewal did not cause any clonal selection...
November 16, 2017: Nature
https://www.readbyqxmd.com/read/29143793/marrubium-vulgare-l-leave-extract-phytochemical-composition-antioxidant-and-wound-healing-properties
#13
Bédis Amri, Emanuela Martino, Francesca Vitulo, Federica Corana, Leila Bettaieb-Ben Kaâb, Marta Rui, Daniela Rossi, Michela Mori, Silvia Rossi, Simona Collina
Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults...
October 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29140838/assessing-specimens-of-devitalized-tissue-in-chronic-sacral-pressure-ulcers-a-pilot-study
#14
Juliany Lino Gomes Silva, Andressa Coope, Eliana Pereira de Araújo, Licio A Velloso, Mário José A Saad, Maria Helena Melo Lima
Pressure ulcers (PrUs)* are chronic wounds caused by a combination of factors, such as repetitive ischemia perfusion injury, bacterial colonization of the wound bed, local tissue hypoxia, or an altered cellular and systemic stress response. The objectives of this study were to analyze fragments of devitalized tissue of Stages III and IV PrUs and compare them with healthy tissue to evaluate the expression of the genes involved in wound inflammation. Samples of healthy skin from patients undergoing plastic surgery (n = 3) were collected, as well as from patients with devitalized tissue from Stages III and IV PrUs (n = 3) by means of sharp debridement...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29139176/costs-of-an-ostomy-self-management-training-program-for-cancer-survivors
#15
Mark C Hornbrook, Martha D Cobb, Nancy J Tallman, Janice Colwell, Ruth McCorkle, Elizabeth Ercolano, Marcia Grant, Virginia Sun, Christopher S Wendel, Judith H Hibbard, Robert S Krouse
OBJECTIVE: To measure incremental expenses to an oncologic surgical practice for delivering a community-based, ostomy nurse-led, small-group, behavior skills-training intervention to help bladder and colorectal cancer survivors understand and adjust to their ostomies and improve their health-related quality of life, as well as assist family caregivers to understand survivors' needs and provide appropriate supportive care. METHODS: The intervention was a five-session group behavior skills training in ostomy self-management following the principles of the Chronic Care Model...
November 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29138622/antimicrobial-efficacy-of-penicillium-amestolkiae-elv609-extract-treated-cotton-fabric-for-diabetic-wound-care
#16
Nur Amiera Syuhada Binti Rozman, Nurhanis Syafiqah Binti Mohd Nor Hamin, Leong Chean Ring, Tan Wen Nee, Mahfuzah Binti Mustapha, Tong Woei Yenn
Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Foot ulceration and wound infection are major forms of disabilities arising from diabetic diseases. This study was aimed to develop a natural antimicrobial finishing on medical grade textile that meets American Association of Textiles Chemists and Colorists (AATCC) standard. The textile samples were finished with the ethanolic extract of Penicillium amestolkiae elv609, an endophytic fungus isolated from Orthosiphon stamineus Benth (common name: cat's whiskers)...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29135700/safety-outcomes-following-spine-and-cranial-neurosurgery-evidence-from-the-national-surgical-quality-improvement-program
#17
Andrew K Rock, Charles F Opalak, Kathryn G Workman, William C Broaddus
BACKGROUND: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) was used to establish predictors for 30-day postoperative complications following spine and cranial neurosurgery. MATERIALS AND METHODS: The ACS-NSQIP participant use files were queried for neurosurgical cases between 2005 and 2015. Prevalence of postoperative complications following neurosurgery was determined. Nested multivariable logistic regression analysis was used to identify demographic, comorbidity, and perioperative characteristics associated with any complication and mortality for spine and cranial surgery...
November 10, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29134555/ciprofloxacin-loaded-calcium-alginate-wafers-prepared-by-freeze-drying-technique-for-potential-healing-of-chronic-diabetic-foot-ulcers
#18
Asif Ahmed, Giulia Getti, Joshua Boateng
Calcium alginate (CA) wafer dressings were prepared by lyophilization of hydrogels to deliver ciprofloxacin (CIP) directly to the wound site of infected diabetic foot ulcers (DFUs). The dressings were physically characterized by scanning electron microscopy (SEM), texture analysis (for mechanical and in vitro adhesion properties), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Further, functional properties essential for wound healing, i.e., porosity, in vitro swelling index, water absorption (Aw), equilibrium water content (EWC), water vapor transmission rate (WVTR), evaporative water loss (EWL), moisture content, in vitro drug release and kinetics, antimicrobial activity, and cell viability (MTT assay) were investigated...
November 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29132871/the-role-of-tgf%C3%AE-in-wound-healing-pathologies
#19
REVIEW
Dimitra Kiritsi, Alexander Nyström
Wound healing is one of the most complex processes in multicellular organisms, involving numerous intra- and intercellular signalling pathways in various cell types. It involves extensive communication between the cellular constituents of diverse skin compartments and its extracellular matrix. Miscommunication during healing may have two distinct damaging consequences: the development of a chronic wound or the formation of a hypertrophic scar/keloid. Chronic wounds are defined as barrier defects that have not proceeded through orderly and timely reparation to regain structural and functional integrity...
November 10, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29132116/the-outcome-of-laparoscopic-subtotal-cholecystectomy-in-difficult-cases-a-case-series
#20
Caroline Supit, Tommy Supit, Yarman Mazni, Ibrahim Basir
INTRODUCTION: Laparoscopic subtotal cholecystectomy (LSC) is a widely used technique for managing cholelithiasis with severe cholecystitis. The increasing popularity its utilization is due to the good safety profile and acceptable results. This case series evaluates the short- and long-term results of Indonesian patients who underwent LSC with an objective to determine whether the procedure can be a standard approach for difficult cholecystectomy in our institution. PRESENTATION OF CASE: Thirty-four Indonesian patients (26 men, 8 women) with the mean age of 54...
November 8, 2017: International Journal of Surgery Case Reports
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