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https://www.readbyqxmd.com/read/29775967/bilateral-breast-calciphylaxis-in-a-patient-who-survived-earlier-extensive-tissue-necrosis-5-years-previously-a-case-report
#1
E M J Verstappen, A J G Maaskant-Braat, M R Scheltinga
INTRODUCTION: Calciphylaxis is a rare condition including patchy dermal necrosis that mostly affects chronic hemodialysis patients. The syndrome usually heralds impending death although patients may survive following a set of measures including an adapted dialysis regimen. The present case is a unique patient who recovered from an earlier episode of upper leg calciphylaxis 5 years previously but developed fatal bilateral breast necrosis. PRESENTATION OF CASE: A 69 year old Caucasian woman with a history of atrial fibrillation, hypertension, CVA, hyperparathyroidectomy for secondary hyperparathyroidism and end stage renal disease with hemodialysis recovered in 2012 from extensive symptomatic left upper leg necrosis due to calciphylaxis...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29775721/critical-evaluation-of-2-ethylhexyl-acrylate-dermal-carcinogenicity-studies-using-contemporary-criteria
#2
REVIEW
Sandra Murphy, Robert Ellis-Hutchings, Lavorgie Finch, Stefanie Welz, Karin Wiench
Skin tumors have been observed in C3H/HeJ mice following treatment with high and strongly irritating concentrations of 2-ethylhexyl acrylate (2-EHA). Dermal carcinogenicity studies performed with 2-EHA are reviewed, contrasting the results in two mouse strains (C3H/HeJ and NMRI) under different dosing regimens. Application of contemporary evaluation criteria to the existing dermal carcinogenicity dataset demonstrates that 2-EHA induces skin tumors only at concentrations exceeding an maximum tolerated dose (MTD) and in the immune-dysregulated C3H/HeJ mouse model...
May 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29775708/gelatin-alginate-coacervates-for-circumventing-proteolysis-and-probing-intermolecular-interactions-by-spr
#3
Hui-Chong Lau, Seonghee Jeong, Aeri Kim
Complex coacervates based on natural biopolymers have been explored as a protein delivery system to provide controlled release of loaded protein and circumvent its proteolytic degradation in chronic wounds. The coacervates composed of gelatin A (GA) and sodium alginate (SA) were optimized with respect to turbidity, size, zeta potential, and polydispersity index. Bovine serum albumin (BSA), a model protein, was effectively encapsulated in the coacervates, resulting in protection from trypsin digestion and controlled release...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29772758/antioxidant-capacity-of-rigenase-%C3%A2-a-specific-aqueous-extract-of-triticum-vulgare
#4
Immacolata Antonucci, Gabriella Fiorentino, Patrizia Contursi, Massimiliano Minale, Rodolfo Riccio, Salvatore Riccio, Danila Limauro
Reactive species of oxygen (ROS), responsible for oxidative stress, accumulate in various tissues damaged by burns, decubitus ulcers, and vascular lesions. Antioxidants play an important and well-documented role in healing of chronic and acute wounds. Rigenase® , a specific extract of Triticum vulgare manufactured by Farmaceutici Damor, is employed in products used for the regeneration of tissue injuries. In this work, we show that Rigenase® exhibits a scavenging effect toward free radicals, thus pointing to its relevant antioxidant activity...
May 17, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29772321/use-of-polidocanol-endovenous-microfoam-to-improve-hemodynamics-and-symptomology-in-patients-with-challenging-clinical-presentations-a-case-series
#5
Paul E Davis, John Phillips, Raghu Kolluri
BACKGROUND: We performed a retrospective review of treatment effects with FDA-approved Polidocanol endovenous microfoam (PEM, Varithena® 1%) on venous symptomology in ten (N=10) C3-C6 patients with chronic venous insufficiency (CVI) and concomitant complex disease/pathology that limited the use of endothermal ablation (ETA). METHODS: Pathology included: risk of bruising or bleeding, severe lipodermatosclerosis (LDS), Hydradenitis Suppurativa, chronic fibrosis of the vein from prior superficial thrombosis, risk for nerve injury and failed prior ETA...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29767913/development-of-coverage-and-its-evaluation-in-the-treatment-of-chronic-wounds
#6
Marcia Diana Umebayashi Zanoti, Helena Megumi Sonobe, Sidney José Lima Ribeiro, Ana Maria Minarelli Gaspar
OBJECTIVES: To describe the development of the bacterial cellulose coating with anti-inflammatory Ibuprofen (BC/Ibu) and to evaluate the cicatrization process with its use in patients with chronic wounds of venous and diabetic etiology. METHODS: Longitudinal descriptive study. The cellulose membrane, cultivated with bacteria Gluconacetobacter xylinus and with incorporation of Ibuprofen, was used in the treatment of patients with chronic wounds in public health services in a Brazilian municipality...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29767448/development-and-validation-of-a-fast-and-sensitive-uhplc-esi-ms-method-for-the-simultaneous-quantification-of-spironolactone-and-its-metabolites-in-ocular-tissues
#7
Naoual Dahmana, Doris Gabriel, Robert Gurny, Yogeshvar N Kalia
Glucocorticoids are a mainstay for the treatment of immune-mediated conditions and inflammatory diseases. However, their chronic use causes numerous side-effects including delays in corneal and cutaneous wound healing. This is attributed to off-target agonism of the mineralocorticoid receptor, which can be reduced by co-administration of a mineralocorticoid receptor antagonist such as spironolactone. The aim of this study was to develop a fast, selective and sensitive UHPLC-ESI-MS method for the simultaneous quantification of spironolactone, its active metabolites - 7α-thiomethylspironolactone and canrenone, the latter's water-soluble prodrug potassium canrenoate, and the synthetic glucocorticoid, dexamethasone, in corneal samples (17α-methyltestosterone served as an internal standard)...
May 16, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29765329/the-role-of-macrophages-in-acute-and-chronic-wound-healing-and-interventions-to-promote-pro-wound-healing-phenotypes
#8
REVIEW
Paulina Krzyszczyk, Rene Schloss, Andre Palmer, François Berthiaume
Macrophages play key roles in all phases of adult wound healing, which are inflammation, proliferation, and remodeling. As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti-inflammatory (M2-like phenotypes). Non-healing chronic wounds, such as pressure, arterial, venous, and diabetic ulcers indefinitely remain in inflammation-the first stage of wound healing. Thus, local macrophages retain pro-inflammatory characteristics. This review discusses the physiology of monocytes and macrophages in acute wound healing and the different phenotypes described in the literature for both in vitro and in vivo models...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29763740/combining-magnetic-resonance-imaging-mri-and-medical-infrared-thermography-mit-in-the-pre-and-per-operating-management-of-severe-hidradenitis-suppurativa-hs
#9
Stéphane Derruau, Yohann Renard, Hervé Pron, Redha Taiar, Ellie Abdi, Guillaume Polidori, Sandrine Lorimier
Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurrent skin disease. Surgical excision of wounds appears to be the only curative treatment for the prevention of recurrence of moderate to severe stages. Magnetic resonance imaging (MRI) is a standard reference examination for the detection of HS peri-anal inflammatory fistula. In this case study, the use of real-time medical infrared thermography, in combination with MRI as appropriate imaging, is proposed. The aim is to assist surgeons in the pre- and peri-surgical management of severe perianal hidradenitis suppurativa with the intent to ensure that all diseased lesions were removed during surgery and therefore to limit recurrence...
May 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29761573/using-fat-to-fight-disease-a-systematic-review-of-non-homologous-adipose-derived-stromal-stem-cell-therapies
#10
REVIEW
Marjorie E Bateman, Amy L Strong, Jeffrey M Gimble, Bruce A Bunnell
OBJECTIVE: The objective of this review is to describe the safety and efficacy of ASC and SVF in treating common diseases and the next steps in research that must occur prior to clinical use. EVIDENCE REVIEW: Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients...
May 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29761496/contact-dermatitis-caused-by-dialkylcarbamoyl-compounds-in-a-medication-used-for-chronic-wounds
#11
Monica Corazza, Graziana Amendolagine, Dario Cristofaro, Tatiana Bernardi, Alessandro Borghi
No abstract text is available yet for this article.
May 15, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29761298/lumbar-muscle-atrophy-caused-by-harness-replacement-in-a-chronic-calf-model-of-total-artificial-heart-implantation
#12
Jamshid H Karimov, Kimberly A Such, Raymond Dessoffy, Kiyotaka Fukamachi
The postoperative care of animals implanted with mechanical circulatory support devices is complex. The standard of care requires continuous monitoring of hemodynamic parameters post implant, wound care, and maintenance of the animal's well-being, but also includes controlling the animal's biomechanics under conditions of continuous restraint and harnessing. In such studies, a harness provides secure fixation of the exteriorized device driveline and pressure lines and aids animal handling (lifting, position adjustment, and assistance with standing up)...
May 14, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29760148/bacterial-silver-resistance-gained-by-cooperative-interspecies-redox-behavior
#13
Michael Muller
Silver has emerged as an important therapeutic option for wound infections in recent years due to its broad spectrum antimicrobial activity. The silver cation (Ag+ ), but not the bulk metal (Ag0 ), is highly toxic for most microorganisms although resistance due to genetic modification or horizontal gene transfer does occur. Pseudomonas aeruginosa , however, achieves silver resistance by producing the redox active metabolite pyocyanin that reduces Ag+ to non-toxic Ag0 Pyocyanin also possess broad spectrum antimicrobial activity...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29757677/microrna-dysregulation-in-pulmonary-arteries-from-copd-relationships-with-vascular-remodeling
#14
Melina M Musri, Núria Coll-Bonfill, Bradley A Maron, Víctor I Peinado, Ruisheng Wang, Jordi Altirriba, Isabel Blanco, William M Oldham, Olga Tura-Ceide, Jessica García-Lucio, Benjamin de la Cruz-Thea, Gunter Meister, Joseph Loscalzo, Joan A Barberà
BACKGROUND: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small non-coding RNAs that regulate mRNA expression levels of many genes leading to the manifestation of cell identity and specific cellular phenotypes. Here we evaluate the miRNA expression profiles of pulmonary arteries (PA) of patients with COPD and its relationship with the regulation of SMC phenotypic change...
May 14, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29757659/bone-marrow-derived-mesenchymal-stem-cells-promoted-cutaneous-wound-healing-by-regulating-keratinocyte-migration-via-the-%C3%AE-2-adrenergic-receptor-signaling
#15
Jiahui Huo, Sujing Sun, Zhijun Geng, Wei Sheng, Runkai Chen, Kui Ma, Xiaoyan Sun, Xiaobing Fu
Mesenchymal stem cells (MSCs) play an important role in the cutaneous wound healing; however, the functional mechanisms involved in the healing process are poorly understood. A series of studies indicate that keratinocytes which migrate into the wound bed rely on an epithelial-mesenchymal transition (EMT)-like process to initiate re-epithelialization. We therefore examined whether bone marrow-derived MSCs (BMSCs) could affect biological behavior and induce EMT-like characteristics in the human epidermal keratinocytes (HEKs) and in the immortalized human keratinocyte cell line HaCaT cells; and we investigated the signaling pathways of BMSC-mediated phenotypic changes...
May 14, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29756537/use-of-negative-pressure-wound-therapy-in-a-chronic-leg-wound-with-coexisting-rheumatoid-arthritis-a-case-study
#16
Dariusz Bazaliński, Paweł Więch, Beata Barańska, Monika Binkowska-Bury
We present a case of a 69-year-old woman with rheumatoid arthritis. The patient's condition was managed with steroid therapy for more than 12 years. She had a coexisting infected chronic ulceration in the left leg, which was treated with negative pressure wound therapy for 52 days. Use of this therapy within the wound reduced exudate and the bacterial count, which dramatically accelerated the process of wound healing.
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29755977/wearable-technology-for-chronic-wound-monitoring-current-dressings-advancements-and-future-prospects
#17
REVIEW
Matthew S Brown, Brandon Ashley, Ahyeon Koh
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29755898/an-unusual-presentation-of-kikuchi-fujimoto-disease-with-recurrent-subdural-effusion
#18
Sara Shahid, Syed H Alam, Indira Hadley
A 24-year-old man complained of a right temporal headache for four weeks. The patient denied any trauma or previous anticoagulation use. He also reported tender right facial swelling. His physical exam was unrevealing except for right cranial nerve (CN) VI palsy, right parotid enlargement, and cervical adenopathy. Laboratory findings were significant for mild leukopenia at 3300 cells/uL. The computed tomography (CT) scan obtained showed a chronic left subdural effusion with a 4 mm midline shift and confirmed right parotid enlargement and cervical lymphadenopathy...
March 10, 2018: Curēus
https://www.readbyqxmd.com/read/29754186/flexor-hallucis-longus-transfer-clinical-outcome-through-a-single-incision-for-chronic-achilles-tendon-rupture
#19
Hossam Abubeih, Mohamed Khaled, Waleed Riad Saleh, Galal Z Said
PURPOSE: The aim of this study is to evaluate the clinical outcome of single-incision flexor hallucis longus tendon transfer in chronic Achilles tendon rupture. METHODS: A prospective study of a series of cases of chronic Achilles tendon rupture that were treated with single-incision flexor hallucis longus tendon transfer, from April 2015 to December 2016. The study included 21 patients (15 men and 6 women), with mean age 40.3 ± 17.5 years. The average follow-up time was 15 (12-24) months...
May 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#20
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
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