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JOURNAL ARTICLE
Shinichi Matsumoto, Satoshi Goto
No abstract text is available yet for this article.
January 23, 2024: Journal of Movement Disorders
#22
JOURNAL ARTICLE
Dasheng Tian, Xingyu You, Jianan Ye, Gan Chen, Hang Yu, Jianwei Lv, Fangli Shan, Chao Liang, Yihui Bi, Juehua Jing, Meige Zheng
After spinal cord injury (SCI), the accumulation of myelin debris at the lesion exacerbates cell death and hinders axonal regeneration. Transplanted bone marrow mesenchymal stem cells (BMSCs) have been proven to be beneficial for SCI repair, but they are susceptible to apoptosis. It remains unclear whether this apoptotic process is influenced by myelin debris. Here, we constructed rat BMSCs overexpressing human B-cell lymphoma 2 (hBcl2) alone (hBcl2 group), BMSCs overexpressing hBcl2 with an endoplasmic reticulum-anchored segment (hBcl2-cb) (cb group), and a negative control group (NC group) for transplantation in this study...
January 21, 2024: Scientific Reports
#23
JOURNAL ARTICLE
Hutao Xie, Ming Shan, Shu Wang, Yu Diao, Quan Zhang, Yifei Gan, Jiansong Huang, Zihan Yin, Guofan Qin, Tianqi Hu, Houyou Fan, Yichen Xu, Xin Zhang, Anchao Yang, Fangang Meng, Yutong Bai, Jianguo Zhang
OBJECTIVE: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has demonstrated efficacy against multiple types of dystonia, but only a few case reports and small-sample studies have investigated the clinical utility of STN-DBS for Meige syndrome, a rare but distressing form of craniofacial dystonia. Furthermore, the effects of DBS on critical neuropsychological sequelae, such as depression and anxiety, are rarely examined. In this study, the authors investigated the therapeutic efficacy of STN-DBS for both motor and psychiatric symptoms of Meige syndrome...
January 19, 2024: Journal of Neurosurgery
#24
JOURNAL ARTICLE
Xianwen Hu, Wenxin Li, Xiaotian Li, Dandan Li, Jiong Cai, Pan Wang
The objective of this study was retrospectively to analyze the clinical characteristics and 18 F-FDG PET/CT findings in Meigs syndrome (MS) patients. A total of 21 patients with MS induced by ovarian stromal tumors and 69 patients with pseudo-MS caused by ovarian cancer (OC-PMS) were subjected to evaluation using 18 F-FDG PET/CT. Visual and semi-quantitative methods were employed to analyze the PET/CT findings. Visual analysis included recording whether the density of the primary tumor was uniform, whether there were cystic changes and calcifications, and the location of serous fluid accumulation...
January 3, 2024: Scientific Reports
#25
JOURNAL ARTICLE
Xuemei Li, Li Su, Yi Zhao
This report details a rare case where a patient simultaneously suffered from Sjogren's syndrome (SS) and Meige's syndrome (MS). SS, an autoimmune disorder, and MS, a rare neurological condition characterized by involuntary eyelid closure, presented in a 73-year-old male. The patient had been experiencing dry eye symptoms for the past 5 years, with the onset of eyelid spasms and tetanic eye closure occurring 3 years ago. Traditional treatments, including subthalamic nucleus deep brain stimulation, provided only temporary relief...
December 10, 2023: Journal of Neuroimmunology
#26
Abdifatah Abdi Ali, Baanitse Munihire Jeannot, Anthony Ayotunde Olasinde, Yusuf Abdirizak, Abdirahin Omar Amin, Joshua Muhumuza, Franck Katembo Sikakulya
INTRODUCTION AND IMPORTANCE: Demons-Meigs syndrome is a rare condition characterized by the presence of a benign fibroma of the ovary, ascites, and pleural effusion. It is very uncommon, and the diagnosis is made with difficulty based on symptoms that usually mimic disseminated malignancy or tuberculosis, but imaging may confirm the diagnosis. The definitive treatment is laparotomy, after which the symptoms resolve. CASE PRESENTATION: We present a 36-year-old female with Demons-Meigs' syndrome with severe dyspnea who underwent an abdominal surgical exploration, which revealed ascites of 1500 ml and an ovarian fibroma weighing 7...
December 2023: Annals of Medicine and Surgery
#27
Halil Onder, Selcuk Comoglu
No abstract text is available yet for this article.
December 2023: Movement Disorders Clinical Practice
#28
Diana Oliveira, David Moura, Sofia Azevedo, Bruno Guimarães, Sofia Toste
Oromandibular dystonia is a focal dystonia characterized by involuntary movements of the jaw, oropharynx, lips, and tongue. The diagnosis of oromandibular dystonia is clinical and can be complex. For effective treatment, it is essential to understand its underlying etiology. A 70-year-old man was referred to our center with a diagnosis of Meige's syndrome, which had been present for five and a half years, for receiving botulinum toxin-A (BoNT-A) injections. Upon physical examination, he exhibited oromandibular dystonia, with a score of 177 points on the Oromandibular Dystonia Rating Scale (OMDRS)...
October 2023: Curēus
#29
JOURNAL ARTICLE
Natalie R Hasbani, Kenneth E Westerman, Soo Heon Kwak, Han Chen, Xihao Li, Daniel Dicorpo, Jennifer Wessel, Joshua C Bis, Chloè Sarnowski, Peitao Wu, Lawrence F Bielak, Xiuqing Guo, Nancy Heard-Costa, Gregory Kinney, Michael C Mahaney, May E Montasser, Nicholette D Palmer, Laura M Raffield, James G Terry, Lisa R Yanek, Jessica Bon, Donald W Bowden, Jennifer A Brody, Ravindranath Duggirala, David R Jacobs, Rita R Kalyani, Leslie A Lange, Braxton D Mitchell, Jennifer A Smith, Kent D Taylor, April Carson, Joanne E Curran, Myriam Fornage, Barry I Freedman, Stacey Gabriel, Richard A Gibbs, Namrata Gupta, Sharon L R Kardia, Brian G Kral, Zeineen Momin, Anne B Newman, Wendy S Post, Karine A Viaud-Martinez, Kendra A Young, Lewis C Becker, Alain Bertoni, John Blangero, John J Carr, Katherine Pratte, Bruce M Psaty, Stephen S Rich, Joseph C Wu, Rajeev Malhotra, Patricia A Peyser, Alanna C Morrison, Ramachandran S Vasan, Xihong Lin, Jerome I Rotter, James B Meigs, Alisa K Manning, Paul S de Vries
BACKGROUND: Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Identifying which CAD loci are modified by T2D in the development of subclinical atherosclerosis (coronary artery calcification [CAC], carotid intima-media thickness, or carotid plaque) may improve our understanding of the mechanisms leading to the increased CAD in T2D. METHODS: We compared the common and rare variant associations of known CAD loci from the literature on CAC, carotid intima-media thickness, and carotid plaque in up to 29 670 participants, including up to 24 157 normoglycemic controls and 5513 T2D cases leveraging whole-genome sequencing data from the Trans-Omics for Precision Medicine program...
November 28, 2023: Circulation. Genomic and Precision Medicine
#30
Joseph H Breeyear, Sabrina L Mitchell, Cari L Nealon, Jacklyn N Hellwege, Brian Charest, Anjali Khakharia, Christopher W Halladay, Janine Yang, Gustavo A Garriga, Otis D Wilson, Adriana M Hung, Peter D Reaven, James B Meigs, Mary K Rhee, Yang Sun, Mary G Lynch, Lucia Sobrin, Milam A Brantley, Yan V Sun, Peter W Wilson, Sudha K Iyengar, Neal S Peachey, Lawrence S Phillips, Todd L Edwards, Ayush Giri
OBJECTIVES/AIMS: To develop, validate and implement algorithms to identify diabetic retinopathy (DR) cases and controls from electronic health care records (EHR)s. METHODS: We developed and validated EHR-based algorithms to identify DR cases and individuals with type I or II diabetes without DR (controls) in three independent EHR systems: Vanderbilt University Medical Center Synthetic Derivative (VUMC), the VA Northeast Ohio Healthcare System (VANEOHS), and Massachusetts General Brigham (MGB)...
November 15, 2023: medRxiv
#31
Varun Dang, Andrew Rofail, Jade M Bowman, Joshua Peloquin
Pseudo-pseudo Meigs' syndrome (PPMS), also known as Tjalma syndrome, is a rare complication of systemic lupus erythematosus (SLE), characterized by a triad of ascites, pleural effusion, and elevated CA-125 levels. We report a case involving a 74-year-old female with a prior history of SLE who presented with recurrent bilateral pleural effusions, elevated CA-125 levels, and mild ascites. Imaging showed no evidence of any mass or malignancy. In this case, the patient's presentation aligned with the diagnostic criteria for PPMS...
October 2023: Curēus
#32
JOURNAL ARTICLE
Theresa Mottes, Shina Menon, Andrea Conroy, Jennifer Jetton, Kristin Dolan, Ayse Akcan Arikan, Rajit K Basu, Stuart L Goldstein, Jordan M Symons, Rashid Alobaidi, David J Askenazi, Sean M Bagshaw, Matthew Barhight, Erin Barreto, Benan Bayrakci, O N Bignall Ray, Erica Bjornstad, Patrick Brophy, Jennifer Charlton, Rahul Chanchlani, Andrea L Conroy, Akash Deep, Prasad Devarajan, Dana Fuhrman, Katja M Gist, Stephen M Gorga, Jason H Greenberg, Denise Hasson, Emma Heydari, Arpana Iyengar, Catherine Krawczeski, Leslie Meigs, Catherine Morgan, Jolyn Morgan, Tara Neumayr, Zaccaria Ricci, David T Selewski, Danielle Soranno, Natalja Stanski, Michelle Starr, Scott M Sutherland, Jordan Symons, Marcelo Tavares, Molly Vega, Michael Zappitelli, Claudio Ronco, Ravindra L Mehta, John Kellum, Marlies Ostermann
BACKGROUND: Acute kidney injury (AKI) is independently associated with increased morbidity and mortality across the life course, yet care for AKI remains mostly supportive. Raising awareness of this life-threatening clinical syndrome through education and advocacy efforts is the key to improving patient outcomes. Here, we describe the unique roles education and advocacy play in the care of children with AKI, discuss the importance of customizing educational outreach efforts to individual groups and contexts, and highlight the opportunities created through innovations and partnerships to optimize lifelong health outcomes...
November 7, 2023: Pediatric Nephrology
#33
JOURNAL ARTICLE
Qing-Pei Hao, Wen-Tao Zheng, Zi-Hao Zhang, Ye-Zu Liu, Hu Ding, Jia OuYang, Zhi Liu, Guang-Yong Wu, Ru-En Liu
BACKGROUND AND PURPOSE: Deep brain stimulation (DBS) has emerged as a promising treatment for movement disorders. This prospective study aims to evaluate the effects of bilateral subthalamic nucleus DBS (STN-DBS) on motor and non-motor symptoms in patients with primary Meige syndrome. METHODS: Thirty patients who underwent bilateral STN-DBS between April 2017 and June 2020 were included. Standardized and validated scales were utilized to assess the severity of dystonia, health-related quality of life, sleep, cognitive function and mental status at baseline and at 1 year and 3 years after neurostimulation...
February 2024: European Journal of Neurology
#34
JOURNAL ARTICLE
Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S DeCarli, Nancy L Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B Meigs, Claudia L Satizabal, Jose C Florez, Marie-France Hivert, Josée Dupuis, Philip L De Jager, David A Bennett, Sudha Seshadri, Alanna C Morrison
BACKGROUND: Insulin resistance (IR) is a major risk factor for Alzheimer's disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biological and regulatory mechanisms linking IR and AD. METHODS: We conducted an epigenome-wide association study of IR, quantified using the homeostatic model assessment of IR (HOMA-IR) and adjusted for body mass index, in 3,167 participants from the Framingham Heart Study (FHS) without type 2 diabetes at the time of blood draw used for methylation measurement...
October 27, 2023: Clinical Epigenetics
#35
REVIEW
Thorsten M Odorfer, Jens Volkmann
(1) Background: The first-line treatment for patients with focal or segmental dystonia with a craniocervical distribution is still the intramuscular injection of botulinum neurotoxin (BoNT). However, some patients experience primary or secondary treatment failure from this potential immunogenic therapy. Deep brain stimulation (DBS) may then be used as a backup strategy in this situation. (2) Methods: Here, we reviewed the current study literature to answer a specific question regarding the efficacy and safety of the use of DBS, particularly for cervical dystonia (CD) and Meige syndrome (MS) in patients with documented treatment failure under BoNT...
October 9, 2023: Toxins
#36
Fathi Mraihi, Jihene Basly, Feryal Slama, Eya Azouz, Asma Ayari, Dalenda Chelli
INTRODUCTION: Ovarian fibrosarcoma is a rare cancer. In the literature, there have been very few occurrences of fibrosarcoma with ascites. The presence of ascites complicates the diagnosis further, and is associated with a poor prognosis and has been linked to chemoresistance and metastasis. We present this case of an ovarian fibrosarcoma with ascites to provide a comprehensive overview of the clinical presentation, diagnostic evaluation and management of this pathology, which remains a challenge given the rarity of this entity...
October 10, 2023: International Journal of Surgery Case Reports
#37
Mikio Takehara, Keisuke Ashihara, Tomomi Fukunishi, Seigo Ibuchi, Yukari Mukai
Malignant solitary fibrous tumors in the retroperitoneum are rare, and their treatment strategies have not yet been established. A 61-year-old woman with dyspnea underwent laparotomy under a presumptive diagnosis of Meigs' syndrome. She underwent both adnexectomy and retroperitoneal tumor excision. The histologic diagnosis was of a fibrothecoma of both ovaries and a retroperitoneal solitary fibrous tumor that was considered malignant based on its mitotic activity. Local recurrence was observed 9 months postoperatively; re-excision was performed, and radiation therapy was administered...
December 2023: Radiology Case Reports
#38
JOURNAL ARTICLE
Flávio A Fowler, Cristina Yabumoto, Midori H Osaki, Gustavo R Gameiro, Janaina L Brabo, Suzana Matayoshi, Regina C R S Marinho, Tammy H Osaki
PURPOSE: Information is scarce regarding the comprehensive profile of patients with essential blepharospasm and hemifacial spasm in Brazil. The present study aimed to assess the clinical features of patients with these conditions, followed up in two reference centers in Brazil. METHODS: The study included patients with essential blepharospasm and hemifacial spasm, followed up at the Departments of Ophthalmology at Universidade Federal de São Paulo and Universidade de São Paulo...
2023: Arquivos Brasileiros de Oftalmologia
#39
JOURNAL ARTICLE
Shylaja Srinivasan, Peitao Wu, Josep M Mercader, Miriam S Udler, Bianca C Porneala, Traci M Bartz, James S Floyd, Colleen Sitlani, Xiquing Guo, Jeffrey Haessler, Charles Kooperberg, Jun Liu, Shahzad Ahmad, Cornelia van Duijn, Ching-Ti Liu, Mark O Goodarzi, Jose C Florez, James B Meigs, Jerome I Rotter, Stephen S Rich, Josée Dupuis, Aaron Leong
CONTEXT: Both type 1 diabetes (T1D) and type 2 diabetes (T2D) have significant genetic contributions to risk and understanding their overlap can offer clinical insight. OBJECTIVE: We examined whether a T1D polygenic score (PS) was associated with a diagnosis of T2D in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. METHODS: We constructed a T1D PS using 79 known single nucleotide polymorphisms associated with T1D risk...
October 9, 2023: Journal of the Endocrine Society
#40
JOURNAL ARTICLE
Eugénie Girouard, Ariel Levy
No abstract text is available yet for this article.
October 13, 2023: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
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